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Journal articles on the topic 'Interleukin-4'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Wu, Albert Y., Sanjiv Sur, J. Andrew Grant, and Julia W. Tripple. "Interleukin-4/interleukin-13 versus interleukin-5." Current Opinion in Allergy and Clinical Immunology 19, no. 1 (February 2019): 30–37. http://dx.doi.org/10.1097/aci.0000000000000490.

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2

&NA;. "Interleukin-4." Reactions Weekly &NA;, no. 606 (June 1996): 9. http://dx.doi.org/10.2165/00128415-199606060-00029.

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3

&NA;. "Interleukin-4." Reactions Weekly &NA;, no. 468 (September 1993): 8. http://dx.doi.org/10.2165/00128415-199304680-00038.

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4

&NA;. "Interleukin 4." Reactions Weekly &NA;, no. 399 (May 1992): 8. http://dx.doi.org/10.2165/00128415-199203990-00030.

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5

&NA;. "Interleukin 4." Reactions Weekly &NA;, no. 492 (March 1994): 8. http://dx.doi.org/10.2165/00128415-199404920-00033.

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6

Isakson, Peter. "Interleukin 4." Advances in Neuroimmunology 2, no. 1 (January 1992): 55–65. http://dx.doi.org/10.1016/s0960-5428(06)80005-7.

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7

Arreaza, Guillermo A., Mark J. Cameron, and Terry L. Delovitch. "Interleukin-4." Clinical Immunotherapeutics 6, no. 4 (October 1996): 251–60. http://dx.doi.org/10.1007/bf03259087.

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8

Jansen, J. H., W. E. Fibbe, R. Willemze, and J. C. Kluin-Nelemans. "Interleukin-4." Blut 60, no. 5 (May 1990): 269–74. http://dx.doi.org/10.1007/bf01736226.

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9

Banchereau, Jacques. "Interleukin 4." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 17, no. 7 (January 1990): 619–23. http://dx.doi.org/10.1016/0883-2897(90)90074-b.

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10

Van Epps, Heather L. "Indecisive interleukin-4?" Journal of Experimental Medicine 201, no. 12 (June 20, 2005): 1867. http://dx.doi.org/10.1084/jem20112iti3.

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11

Smith, Lorna J., Christina Redfield, Jonathan Boyd, G. Mark P. Lawrence, Robert G. Edwards, Richard A. G. Smith, and Christopher M. Dobson. "Human interleukin 4." Journal of Molecular Biology 224, no. 4 (April 1992): 899–904. http://dx.doi.org/10.1016/0022-2836(92)90457-u.

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12

Kelly-Welch, A., E. M. Hanson, and A. D. Keegan. "Interleukin-4 (IL-4) Pathway." Science Signaling 2005, no. 293 (July 12, 2005): cm9. http://dx.doi.org/10.1126/stke.2932005cm9.

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13

Vargiolu, M., T. Silvestri, E. Bonora, P. Dolzani, L. Pulsatelli, O. Addimanda, L. Mancarella, et al. "Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis." Osteoarthritis and Cartilage 18, no. 6 (June 2010): 810–16. http://dx.doi.org/10.1016/j.joca.2010.02.005.

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14

Maroof, Asher, Michelle Penny, Rosetta Kingston, Clare Murray, Sabita Islam, Penelope A. Bedford, and Stella C. Knight. "Interleukin-4 can induce interleukin-4 production in dendritic cells." Immunology 117, no. 2 (February 2006): 271–79. http://dx.doi.org/10.1111/j.1365-2567.2005.02305.x.

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15

Enzle, K., and G. Schulz. "Regulation of interleukin-4 activity by soluble interleukin-4 receptors." Journal of Clinical Laboratory Analysis 9, no. 6 (1995): 450–55. http://dx.doi.org/10.1002/jcla.1860090617.

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16

FLÓREZ, O., J. MARTÍN, and C. I. GONZÁLEZ. "Interleukin 4, interleukin 4 receptor-α and interleukin 10 gene polymorphisms in Chagas disease." Parasite Immunology 33, no. 9 (August 11, 2011): 506–11. http://dx.doi.org/10.1111/j.1365-3024.2011.01314.x.

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17

Murray, Richard. "Physiologic roles of interleukin-2, interleukin-4, and interleukin-7." Current Opinion in Hematology 3, no. 3 (1996): 230–34. http://dx.doi.org/10.1097/00062752-199603030-00011.

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18

Song, Gwan Gyu, Sang-Cheol Bae, Jae-Hoon Kim, and Young Ho Lee. "Interleukin-4, interleukin-4 receptor, and interleukin-18 polymorphisms and rheumatoid arthritis: a meta-analysis." Immunological Investigations 42, no. 6 (July 24, 2013): 455–69. http://dx.doi.org/10.3109/08820139.2013.804084.

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19

PARRY, R. G., K. M. GILLESPIE, A. PARNHAM, A. G. B. CLARK, and P. W. MATHIESON. "Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy." Clinical Science 96, no. 6 (May 11, 1999): 665–68. http://dx.doi.org/10.1042/cs0960665.

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Minimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy. Polymorphic regions in the genes encoding IL-4 itself and the IL-4 receptor have been demonstrated that may predispose to increased activity. We have analysed these polymorphisms in 149 patients with MCN and 73 controls to test the hypothesis that these loci are involved in genetic predisposition to MCN. In our populations there were no polymorphisms in the IL-4 promoter. We did confirm allelic variation in a dinucleotide repeat in the second intron of the IL-4 gene, but there was no significant difference between allele distributions in MCN and controls. Similarly, allele frequencies for the IL-4 receptor α chain polymorphism were similar in patients and controls. Genetic loci which are believed to influence IL-4 responsiveness and to predispose to atopy do not appear to be associated with susceptibility to MCN.

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20

PARRY, R. G., K. M. GILLESPIE, A. PARNHAM, A. G. B. CLARK, and P. W. MATHIESON. "Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy." Clinical Science 96, no. 6 (June 1, 1999): 665. http://dx.doi.org/10.1042/cs19980391.

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21

Landi, Stefano, Fabio Bottari, Federica Gemignani, Lydie Gioia-Patricola, Elisabeth Guino, Alfonso Osorio, Javier de Oca, Gabriel Capella, Federico Canzian, and Victor Moreno. "Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk." European Journal of Cancer 43, no. 4 (March 2007): 762–68. http://dx.doi.org/10.1016/j.ejca.2006.10.024.

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22

Dolzani, P., E. Olivotto, E. Assirelli, S. Pagani, L. Pulsatelli, R. M. Borzì, A. Facchini, F. Flamigni, A. Facchini, and R. Meliconi. "184 INTERLEUKIN-4/INTERLEUKIN-4 RECEPTOR SYSTEM ACTIVITY IN OSTEOARTHRITIC CHONDROCYTES." Osteoarthritis and Cartilage 16 (September 2008): S90. http://dx.doi.org/10.1016/s1063-4584(08)60230-7.

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23

Holter, Wolfgang. "Regulation of Interleukin 4 Production and of Interleukin 4-Producing Cells." International Archives of Allergy and Immunology 98, no. 4 (1992): 273–78. http://dx.doi.org/10.1159/000236198.

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24

Rowe, A., and C. B. Bunker. "Interleukin-4 and the interleukin-4 receptor in allergic contact dermatitis." Contact Dermatitis 38, no. 1 (January 1998): 36–39. http://dx.doi.org/10.1111/j.1600-0536.1998.tb05634.x.

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25

BRINCKMANN, Roland, Max S. TOPP, Ildikó ZALÁN, Dagmar HEYDECK, Peter LUDWIG, Hartmut KÜHN, Wolfgang E. BERDEL, and Andreas J. R. HABENICHT. "Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4." Biochemical Journal 318, no. 1 (August 15, 1996): 305–12. http://dx.doi.org/10.1042/bj3180305.

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We have studied the expression of the 15-lipoxygenase gene in various permanent mammalian cell lines in response to interleukins-4 and -13, and found that none of the cell lines tested expressed 5-, 12- or 15-lipoxygenase when cultured under standard conditions. However, when the lung carcinoma cell line A549 was maintained in the presence of either interleukin for 24 h or more, we observed a major induction of 15-lipoxygenase, as indicated by quantification of 15-lipoxygenase mRNA, by immunohistochemistry, by immunoblot analysis and by enzyme activity assays. This effect was 15-lipoxygenase-specific, since expression of 5- and 12-lipoxygenases remained undetectable. The time course of interleukin-4 treatment indicated maximal accumulation of both 15-lipoxygenase mRNA and functional protein after 48 h. Binding studies revealed that A549 cells express about 2100 high-affinity interleukin-4 binding sites per cell. The interleukin-4 mutant Y124D, which is capable of binding to the interleukin-4 receptor but is unable to trigger receptor activation, counteracted the effect of the wild-type cytokine. Other cell lines, including several epithelial cells and various monocytic cell lines expressing comparable numbers of interleukin-4 receptors, did not express 15-lipoxygenase when stimulated with interleukin-4. These data indicate that A549 cells selectively express 15-lipoxygenase when stimulated with interleukins-4 and -13. The activation of the interleukin-4/13 receptor(s) appears to be mandatory, but not sufficient, for 15-lipoxygenase gene expression.

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26

Yamasaki, Satoshi, and Atsushi Kawakami. "4. Interleukin-1 Inhibitor." Nihon Naika Gakkai Zasshi 100, no. 10 (2011): 2985–90. http://dx.doi.org/10.2169/naika.100.2985.

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27

Kaufman, Stefan H. E., Masashi Emoto, Gudrun Szalay, Johannes Barsig, and Inge E. A. Flesch. "Interleukin-4 and listeriosis." Immunological Reviews 158, no. 1 (August 1997): 95–105. http://dx.doi.org/10.1111/j.1600-065x.1997.tb00995.x.

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28

Ramı́rez, Francisco, Phil Stumbles, Mike Puklavec, and Don Mason. "Rat interleukin-4 assays." Journal of Immunological Methods 221, no. 1-2 (December 1998): 141–50. http://dx.doi.org/10.1016/s0022-1759(98)00176-8.

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29

Müller, W., K. Rajewsky, and R. Kühn. "Interleukin-4-deficient mice." Research in Immunology 144, no. 8 (January 1993): 637–38. http://dx.doi.org/10.1016/s0923-2494(05)80018-5.

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30

Steinke, John W. "Anti–interleukin-4 therapy." Immunology and Allergy Clinics of North America 24, no. 4 (November 2004): 599–614. http://dx.doi.org/10.1016/j.iac.2004.06.008.

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31

Paul, William E. "History of interleukin-4." Cytokine 75, no. 1 (September 2015): 3–7. http://dx.doi.org/10.1016/j.cyto.2015.01.038.

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32

Kelly-Welch, A. E. "Interleukin-4 and Interleukin-13 Signaling Connections Maps." Science 300, no. 5625 (June 6, 2003): 1527–28. http://dx.doi.org/10.1126/science.1085458.

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33

Galanakis, E., A. Makis, K. L. Bourantas, and Z. L. Papadopoulou. "Interleukin-3 and Interleukin-4 in Childhood Brucellosis." Infection 30, no. 1 (January 1, 2002): 33–34. http://dx.doi.org/10.1007/s15010-002-2039-8.

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34

Ho, Steffan N., Robert T. Abraham, Steven Gillis, and David J. McKean. "Differential bioassay of interleukin 2 and interleukin 4." Journal of Immunological Methods 98, no. 1 (April 1987): 99–104. http://dx.doi.org/10.1016/0022-1759(87)90441-8.

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35

Klein, W., A. Tromm, T. Griga, H. Fricke, C. Folwaczny, M. Hocke, K. Eitner, M. Marx, N. Duerig, and JT Epplen. "Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases." Genes & Immunity 2, no. 5 (August 2001): 287–89. http://dx.doi.org/10.1038/sj.gene.6363779.

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36

Najafi, Shamsolmoulouk, Mahsa Mohammadzadeh, Fateme Rajabi, Alireza Zare Bidoki, Hila Yousefi, Elham Farhadi, and Nima Rezaei. "Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis." Immunological Investigations 47, no. 7 (July 9, 2018): 680–88. http://dx.doi.org/10.1080/08820139.2018.1480033.

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37

Galli Sanchez, Ana Paula, and Tatiane Ester Aidar Fernandes. "The Simultaneous Inhibition of IL‑4 and IL‑13 by Dupilumab." Journal of Clinical Research in Dermatology 8, no. 2 (2021): 1–4. http://dx.doi.org/10.15226/2378-1726/8/2/001138.

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Interleukins (IL) IL-4 and IL-13 are key players in diseases in which the Type 2 immune response is predominant, such as atopic dermatitis (AD), asthma, and chronic rhinosinusitis with nasal polyposis (CRSwNP), that are currently being treated with dupilumab. Dupilumab is a fully human IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), preventing both IL-4 and IL-13 mediated signaling. This mini-review summarizes the IL-4 receptor system as well as the mechanism of action of dupilumab. Keywords: IL-4; IL-13; dupilumab; Type 2 immunity Abbreviations AD: Atopic Dermatitis CRSwNP: Chronic Rhinosinusitis with Nasal Polyps DNA: Deoxyribonucleic Acid JAK: Janus Kinase IL: Interleukin IL-4R: Interleukin 4 Receptor IL-4Rα: Interleukin 4 Receptor alpha chain IL-13Rα1: Interleukin 13 Receptor alpha 1 chain IL-13Rα2:Interleukin 13 Receptor alpha 2 chain STAT: Signal Transducer and Activator of Transcription TGF-β: Transforming Growth Factor beta TNF: Tumor Necrosis Factor TYK2: Tyrosine Kinase 2 γc: Common gamma chain

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38

SEWELL, WILLIAM A., and HONG-HUA MU. "Dissociation of production of interleukin-4 and interleukin-5." Immunology and Cell Biology 74, no. 3 (June 1996): 274–77. http://dx.doi.org/10.1038/icb.1996.48.

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39

Callard, R. E., D. J. Matthews, and L. M. Hibbert. "Interleukin 4 and interleukin 13: same response, different receptors." Biochemical Society Transactions 25, no. 2 (May 1, 1997): 451–55. http://dx.doi.org/10.1042/bst0250451.

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40

Iwasaki, Yasuo, Shigeji Baba, and Ken Ikeda. "Interleukin 4 and Interleukin 10 in Creutzfeldt-Jakob Disease." Archives of Neurology 63, no. 6 (June 1, 2006): 911. http://dx.doi.org/10.1001/archneur.63.6.911-a.

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41

Puri, Raj K., and Jay P. Siegel. "Interleukin-4 and Cancer Therapy." Cancer Investigation 11, no. 4 (January 1993): 473–86. http://dx.doi.org/10.3109/07357909309018879.

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42

Snekvik, K. R., J. C. Beyer, G. Bertoni, B. R. Von Beust, T. V. Baszler, G. H. Palmer, T. F. McElwain, and W. P. Cheevers. "Characterization of caprine interleukin-4." Veterinary Immunology and Immunopathology 78, no. 3-4 (February 2001): 219–29. http://dx.doi.org/10.1016/s0165-2427(01)00233-1.

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43

O'Garra, A. "The immunobiology of interleukin 4." Research in Immunology 144, no. 8 (January 1993): 567–68. http://dx.doi.org/10.1016/s0923-2494(05)80003-3.

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44

Baraniuk, James N. "Antisense oligodeoxynucleotides for interleukin-4." Current Allergy and Asthma Reports 4, no. 3 (May 2004): 186. http://dx.doi.org/10.1007/s11882-004-0024-2.

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45

Nagai, Shigenori, and Masakazu Toi. "Interleukin-4 and breast cancer." Breast Cancer 7, no. 3 (August 2000): 181–86. http://dx.doi.org/10.1007/bf02967457.

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46

Keegan, Achsah D., Keats Nelms, Ling-Mei Wang, Jacalyn H. Pierce, and William E. Paul. "Interleukin 4 receptor: signaling mechanisms." Immunology Today 15, no. 9 (September 1994): 423–32. http://dx.doi.org/10.1016/0167-5699(94)90272-0.

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47

Bird, Lucy. "Interleukin-4 boosts macrophage numbers." Nature Reviews Immunology 13, no. 11 (October 25, 2013): 775. http://dx.doi.org/10.1038/nri3555.

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48

Zheng, Kui‐Cheng, and Makoto Ariizumi. "Interleukin‐4 and Interleukin‐5 Expression in Mice Exposed to 2, 4‐Toluene Diisocyanate." Journal of Occupational Health 44, no. 6 (November 2002): 421–26. http://dx.doi.org/10.1539/joh.44.421.

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49

Vargiolu, M., T. Silvestri, E. Bonora, P. Dolzani, L. Pulsatelli, L. Punzi, A. Fioravanti, A. Facchini, G. Romeo, and R. Meliconi. "358 ASSOCIATION OF THE INTERLEUKIN-4/INTERLEUKIN-4 RECEPTOR GENETIC VARIANTS WITH HAND OSTEOARTHRITIS." Osteoarthritis and Cartilage 16 (September 2008): S156. http://dx.doi.org/10.1016/s1063-4584(08)60400-8.

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50

Fernandez-Botran, Rafael, Thomas A. Wynn, Sara Hieny, Patricia Caspar, Paula M. Chilton, and Alan Sher. "Linkedin vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis." European Journal of Immunology 25, no. 3 (March 1995): 649–56. http://dx.doi.org/10.1002/eji.1830250304.

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