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Dissertations / Theses on the topic 'Interleukin-4'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Silfverswärd, Carl-Johan. "Effects of Interleukin-4 and Interleukin-13 on Bone." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8414.

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<p>Cytokines play important roles in bone metabolism, participating in the complex interplay necessary for normal bone formation and turnover. The aim of the present thesis was to investigate the effects of two anti-inflammatory cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13) on bone. </p><p>Influence of pro- and anti-inflammatory cytokines on interleukin-6 (IL-6) formation in cultured human osteoblasts (hOBs) was investigated. IL-4 and IL-13 as well as interleukin-1 (IL-1) and tumour necrosis factor alpha and beta (TNF-α/β) stimulated IL-6 secretion in hOBs. Also, IL-4 and IL-13 sy

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2

Silfverswärd, Carl-Johan. "Effects of Interleukin-4 and Interleukin-13 on Bone /." Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8414.

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3

Parker, Ruth E. "The rat interleukin-4 receptor." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318893.

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4

Traub, Benno [Verfasser]. "Einfluss der Interleukin-4-Interleukin-4-Rezeptor-Kaskade auf den malignen Phänotyp kultivierter Pankreaskarzinomzellen / Benno Traub." Ulm : Universität Ulm, 2017. http://d-nb.info/1140118161/34.

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5

Piehler, Daniel. "The inflammatory response against Cryptococcus neoformans is regulated by eosinophilic granulocytes and the interleukin-4/interleukin-4 receptor axis." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-78248.

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Cytokines play an important regulatory role during immune responses against pathogens. The outcome of an induced cytokine pattern is determined by many factors. It strongly depends on the nature of the pathogen and the host’s ability to control the quality and strength of cytokine signals. In pulmonary infection with Cryptococcus neoformans T helper (Th) 1 and Th17 cell subsets and their associated cytokines confer protection, whereas a Th2-biased response with production of interleukin (IL) -4 confers susceptibility. Since inappropriate Th responses often lead to death in immunosuppressed hum

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6

McKenzie, Grahame James. "Analysis of interleukin-13 and interleukin-4 function using gene targeting." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624953.

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7

Moga, Simona. "Bestimmung der Zytokine Interleukin-1α, Interleukin-1β, Interleukin-2, Interleukin-3 und Interleukin-4 im Vaginalsekret bei Frauen mit Bakterieller Dysbiose". Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-75888.

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8

Clarke, Christopher Jeremy Paul. "Molecular mechanisms of the anti-inflammatory cytokines interleukin-4 and interleukin-10." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285172.

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9

Alvi, Azra Johanna. "Heterogeneity of lymphokine-activated killer cells: Role of interleukin-2 and interleukin-4." Thesis, University of Ottawa (Canada), 1990. http://hdl.handle.net/10393/5579.

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Our main objective was to determine if the Lymphokine Activated Killer cells (LAK) activity is restricted to Natural Killer (NK) cells or if it is also detectable in T cell subsets, especially in CD3+ T cells that are also negative for CD4 and CD8 cell surface markers. We were able to obtain highly purified subsets of NK cells, helper/inducer (CD3+4+8$-$), suppressor/cytotoxic (CD3+4$-$8+) and double negative (CD3+4$-$8$-$) T cells. The double negative T cells are now known to be a subset of $\gamma\delta$-T cells. Highly purified subsets were obtained using antibody (sheep anti-mouse IgG) coa

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10

Schardt, Victor. "Vergleichende Untersuchungen zur Hefepilzbesiedelung von Mundhöhle und Vagina und Bestimmung von Interleukin-4, Interleukin-10 und Interleukin-12." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155152.

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11

Braun, Philipp [Verfasser]. "Expression von Interleukin-4, Interleukin-4 Rezeptor, Interleukin-13 und Interleukin-13 Rezeptor in gastrointestinalen Tumoren und deren Rolle als prognostischer Faktor - eine retrospektive Untersuchung am Tumorgewebe von 454 Patienten / Philipp Braun." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1035699753/34.

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12

Khan, Shamila. "Therapeutic effect of Interleukin-4 and Interleukin-1 Receptor Antagonist in Actinobacillus pleuropneumoniae challenged pigs." Thesis, The University of Sydney, 2005. http://hdl.handle.net/2123/625.

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Immunological stressors, in the form of clinical and sub-clinical disease are currently controlled using both prophylactic antibiotics in-feed, and therapeutic antibiotic treatment. Respiratory disease, primarily Actinobacillus pleuropneumoniae (App) infection, is recognised as a major factor causing reduced productivity in pigs. This thesis reports investigations into the use of novel immunomodulators in particular Interleukin 4 (IL-4) and Interleukin 1 receptor antagonist (IL-1ra) as alternatives to antibiotics to treat App infection. Immunological and molecular biological assays were used t

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13

Cleaver, Catherine Sarah. "The role of interleukin-4 and interleukin-13 in the prevention of cartilage breakdown." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327238.

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14

Lerch, Steffen [Verfasser]. "Interleukin-4 receptor pathway in neurons / Steffen Lerch." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/1173807683/34.

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15

Chakraborty, Rikhia. "Homeostatic Regulation of Interleukin-4-Mediated Cell Signaling." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1258663290.

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16

Azbil, Tatiana. "Nachweis von Candida-Spezies und Bestimmung der Zytokine Interleukin-1 beta, Interleukin-1ra, Interleukin-4, Interleukin-6, Interleukin-8, Interleukin-10 und Interleukin-12 im Vaginalsekret und im Serum bei Schwangeren in Relation zum Gestationsalter." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-57576.

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17

Khan, Shamila. "Therapeutic effect of Interlenkin-4 and Interleukin-1 receptor antagonist in Actinobacillus pleuropneumoniae challenged pigs." University of Sydney. Anatomy and Pathology, 2005. http://hdl.handle.net/2123/625.

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Immunological stressors, in the form of clinical and sub-clinical disease are currently controlled using both prophylactic antibiotics in-feed, and therapeutic antibiotic treatment. Respiratory disease, primarily Actinobacillus pleuropneumoniae (App) infection, is recognised as a major factor causing reduced productivity in pigs. This thesis reports investigations into the use of novel immunomodulators in particular Interleukin 4 (IL-4) and Interleukin 1 receptor antagonist (IL-1ra) as alternatives to antibiotics to treat App infection. Immunological and molecular biological assays were used t

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18

Kampshoff, Jörg. "Die Wirkung der Interleukine 4, 10 und 13 auf die Koinkubation von Endothelzellen und mononukleären Zellen, gemessen an der Freisetzung von PDGF, Interleukin-1-[beta] [Interleukin-1-beta] und Interleukin-6." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972057684.

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19

Kraich, Michael. "Strukturelle und funktionelle Untersuchungen der Interaktion zwischen Ligand und Rezeptor im Interleukin-4- und Interleukin-13-System." Doctoral thesis, kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2008/2765/.

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20

Lasoudris, Fanette. "Immunosuppression associée à l’enzyme interleukine-4 induced gene 1 (IL4I1) : régulation de l’expression dans les cellules humaines et rôle dans l’échappement tumoral à la réponse immune dans un modèle murin." Thesis, Paris Est, 2011. http://www.theses.fr/2011PEST0089/document.

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La protéine IL4I1 est une enzyme sécrétée dont l’activité L-amino acide oxydase vis-à-visde la phénylalanine inhibe la prolifération des lymphocytes T in vitro (Boulland et al, Blood 2007).Comme d’autres enzymes immunosuppressives, elle est exprimée dans les tumeurs au niveau descellules myéloïdes et/ou des cellules tumorales (Carbonnelle-Puscian et al, Leukemia 2009). Le but decette thèse a été de caractériser les conditions d’expression d’IL4I1 et de comprendre son rôle dans lecancer.Nous avons montré que les macrophages et les cellules dendritiques représentent la principalesource d’IL4I1 i

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21

Blalock, Emily L. "Roles of TH2 and TH17 CD4+ T-Helper Cell Cytokines in the Pathogenesis of Experiemental Cytomegalovirus Retinitis." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_diss/122.

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Human cytomegalovirus (HCMV) is a betaherpesvirus that infects up to 80% of the population worldwide, and establishes latency in monocytes and bone marrow cells. Reactivated HCMV can become an opportunistic pathogen in individuals who are immunocompromised, such as those with acquired immunodeficiency syndrome (AIDS). HCMV infection of AIDS patients causes a sight-threatening retinitis that leads to vision loss and blindness in up to 46% of this population without antiretroviral treatment. Because untreated HIV-infected individuals exhibit the loss of cell-mediated immunity and alterations in

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22

Pandey, Shubham. "Identification of Interleukin 4 - CXCL12 supportive loop in follicular lymphoma." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B031/document.

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Le lymphome folliculaire (FL) est le lymphome B indolent le plus fréquent. Outre des altérations géniques récurrentes, le micro-environnement tumoral, et notamment les cellules stromales lymphoides,joue un rôle majeur dans le développement de ce cancer. Cependant, la caractérisation in-situ des cellules stromales lymphoïdes chez l'homme tout comme les facteurs menant à la polarisation du stroma en un stroma protumoral ont été peu étudiés. Dans cette thèse, nous avons montré, que les cellules stromales présentes dans les ganglions et la moelle osseuse envahis des patients atteints de FL surexpr

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23

Arnhold, Markus [Verfasser]. "Einfluss von Interleukin-4 auf die pulmonale Sensibilisierung / Markus Arnhold." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2013. http://d-nb.info/1031271791/34.

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24

Hühner, Laura [Verfasser], and Björn [Akademischer Betreuer] Spittau. "Untersuchungen zur Interleukin-4-vermittelten Protektion dopaminerger Neuronen in vitro." Freiburg : Universität, 2020. http://d-nb.info/1220225592/34.

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25

Schardt, Victor [Verfasser], and Ernst Rainer [Akademischer Betreuer] Weissenbacher. "Vergleichende Untersuchungen zur Hefepilzbesiedelung von Mundhöhle und Vagina und Bestimmung von Interleukin-4, Interleukin-10 und Interleukin-12 / Victor Schardt. Betreuer: Ernst Rainer Weissenbacher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1032862645/34.

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26

Haake, Markus. "Stat6-vermittelte-Genregulation in eukaryontischen Zellen." Doctoral thesis, [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964213702.

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27

Jones, Lucy Helen. "Alternative activation of dendritic cells." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8284.

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The alternative activation of macrophage populations by Interleukin-4 (IL-4) is well characterised. Alternatively activated macrophages (AAM) express high levels of the arginine converting enzyme arginase-1, and express a plethora of IL-4 driven molecules including the resistin like molecule alpha (RELMα) and the chitinase like molecule Ym1/2. Dendritic cells (DCs) are the professional antigen presenting cells (APC) of the immune system, responsible for the detection of invading pathogens, secretion of cytokines and the subsequent activation of T-cells. This thesis addresses whether IL-4 is ab

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28

Banks, Emma M. S. "Mast cell secretory function in vitro : the effects of interleukin-4." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295824.

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29

Deindl, Philipp. "Gen-Gen- und Gen-Umwelt-Interaktionsanalysen bei Kindern der multrizentrischen Allergie-Studie." Doctoral thesis, [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=97415766X.

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30

Davey, Edward. "Regulation of cell morphology and adhesion in B lymphocytes by interleukin-4 /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4429-6/.

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31

McKay, Catriona Elizabeth. "Interleukin-4-mediated regulation of CD25 gene expression in human B lymphocytes." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320283.

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32

Mukherjee, Sumanta. "LPS induced TH2 (Interleukin-4) cytokine production in macrophages and its regulation." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1207743729.

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33

Yang, Liying. "Targeting Interleukin-4 Receptor α with Hybrid Peptide for Effective Cancer Therapy". Kyoto University, 2014. http://hdl.handle.net/2433/188669.

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34

Perron, Lepage Marie-France. "Cloning and sequencing of an alternatively spliced variant of bovine interleukin-4 /." [S.l.] : [s.n.], 1999. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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35

Rilka, Jennifer [Verfasser], and Björn [Akademischer Betreuer] Spittau. "Untersuchungen zu altersabhängigen Veränderungen des nigrostriatalen Systems in Interleukin 4-defizienten Mäusen." Freiburg : Universität, 2016. http://d-nb.info/1124004750/34.

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36

Rai, Muhammad Farooq. "Application of IL-4 transgene expression in a chondrocyte based 3D modell of inflammatory arthritis." Berlin Köster, 2008. http://d-nb.info/990051137/04.

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37

Piehler, Daniel [Verfasser], Gottfried [Akademischer Betreuer] Alber, Gottfried [Gutachter] Alber, and Thomas [Gutachter] Göbel. "The inflammatory response against Cryptococcus neoformans is regulated by eosinophilic granulocytes and the interleukin-4/interleukin-4 receptor axis / Daniel Piehler ; Gutachter: Gottfried Alber, Thomas Göbel ; Betreuer: Gottfried Alber." Leipzig : Universitätsbibliothek Leipzig, 2011. http://d-nb.info/1237895855/34.

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38

Pohjanen, V. M. (Vesa-Matti). "Toll-like receptor 4 and interleukin 6 gene polymorphisms in Helicobacter pylori related diseases." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526212555.

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Abstract Helicobacter pylori is a Gram-negative bacterium, which infects the stomach of more than 50% of the population worldwide. In addition to being the most important risk factor for gastric cancer and peptic ulcers, H. pylori infection is a risk factor for several extra-digestive diseases including dyslipidemia. The consequences of having an H. pylori infection are significantly influenced by the inflammatory response of the host. The pattern recognition receptor Toll-like receptor 4 (TLR4) and the cytokine interleukin 6 (IL6) are important mediators of inflammation in H. pylori related d

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39

Levings, Megan K. "Biological and biochemical analyses of the distinctive intracellular signals activated by interleukin-4." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0025/NQ38928.pdf.

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40

Schmidt, Sebastian [Verfasser]. "Einfluss des Interleukin-4-Rezeptors auf den malignen Phänotyp kultivierter Kolonkarzinomzellen / Sebastian Schmidt." Ulm : Universität Ulm, 2019. http://d-nb.info/1200022017/34.

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41

Skog, Emma. "Betydelsen av interleukin 4 receptorn (IL-4R) i stimulering av lymfom- och leukemiceller." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24758.

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Cytokiner eller interleukiner är signalpeptider med låg molekylär vikt somreglerar många viktiga funktioner. De kan delas in i två grupper beroende på deraseffekt på celler. Interleukin 4 (IL-4) till exempel kan tillhöra gruppentillväxtfaktorer medan interleukin 6 (IL-6) kan tillhöra gruppen aktiverings- ellerdifferentieringsfaktorer. IgM-receptorn eller B-cellsreceptorn, BCR, finns på Bcelleroch är membranbundna immunoglobuliner (mIg) som har tvåhuvuduppgifter; att förmedla signaler som styr B-cellens utveckling samt att bindain antigen som sedan ska presenteras för T-celler. I studien aktive

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42

Woodward, Eleanor. "Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes." Thesis, Woodward, Eleanor (2011) Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes. PhD thesis, Murdoch University, 2011. https://researchrepository.murdoch.edu.au/id/eprint/14844/.

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Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease. In this thesis the mechanisms by which the cytokine, IL-4, can suppress inflammatory cytokine production by LPS-stimulated human monocytes have been examined. IL-4 suppressed LPS-induced TNFα transcription, without inhibiting LPS signalling through IκB, the mitogen-activated protein kinase (MAPK) pathways, or LPS-mediated activation of the transcription factor NF-κB. Histone acetylation regulated LPS-induced

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43

MacÃdo, Francisco Yuri BulÃÃo de. "Efeito protetor da interleucina- 4 na cistite hemorrÃgica induzida por ifosfamida em camundongos." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5159.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A cistite hemorrÃgica (CH) Ã um efeito indesejado limitante do uso clÃnico dos agentes quimioterÃpicos do grupo das oxazafosforinas, principalmente ciclofosfamida (CFS) e ifosfamida (IFS). Isto se deve Ã formaÃÃo de acroleÃna como subproduto do metabolismo dessas drogas. A partir de prÃvios trabalhos conduzidos no LaboratÃrio de Farmacologia da InflamaÃÃo e do CÃncer da Universidade Federal do CearÃ, sabe-se que o Ãxido nÃtrico (NO) atravÃs da ativaÃÃo de iNOS, o fator de ativaÃÃo plaquetÃria, citocinas, como o TNF-α e IL-1&#9

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44

Kim, Paul Hyunchul. "Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/31798.

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Cardiovascular disease (CVD) including atherosclerosis is the leading cause of illness and death in the United States. The American Heart Association indicated that an estimated 81,100,000 American adults have one or more types of CVD and the estimated direct and indirect cost of CVD for 2010 is $503.2 billion, which is $27.9 billion more than last year. Although the exact cause of this disease remains unsolved, previous studies have demonstrated that pro-oxidative and pro-inflammatory pathways in vascular endothelium play a critical role in early pathological events of atherosclerosis. Howeve

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45

David, Muriel. "Régulation de l'expression de la chaîne alpha 2 du récepteur de l'IL-13." Paris 6, 2002. http://www.theses.fr/2002PA066089.

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46

Rauch, Kristin Daniela. "Nachweis von Candida – Spezies, Bewertung von Risikofaktoren für eine Vulvovaginalcandidose und Bestimmung der Zytokine Interleukin-1ß, Interleukin-4, Interleukin-6, Interleukin-8 sowie des Leukämie inhibierenden Faktors LIF im Vaginalsekret von schwangeren Frauen mit Verdacht auf eine Vulvovaginalcandidose." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-121998.

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47

Mukherjee, Sumanta. "LPS induced T[subscript]H2 (Interleukin-4) cytokine production in macrophages and its regulation." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1207743729.

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Dissertation (Ph.D.)--University of Toledo, 2008.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 161-180.

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48

Pyle, Angela. "The mechanism of interleukin-4 inhibition of collagen release from cartilage : implications for arthritis." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399097.

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49

Brombacher, Tiroyaone M. H. "The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/12245.

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Includes abstract.<br>Includes bibliographical references (leaves 101-111).<br>Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N. brasiliensis) and Schistosoma mansoni (S. manson!) infection. Among other cell types, IL-4Ra responsive smooth muscle cells influence immunological responses and are needed for host protection during N. brasiliensis and S. mansoni infection.

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50

Mohamed, Abdel Rahman Ahmed Nada. "The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29830.

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T regulatory (Treg) cells play a pivotal role in the maintenance of self-tolerance and immune homeostasis. Forkhead box P3 (Foxp3)+ Treg function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. Recently, Interleukin (IL)-4 has been shown to play an important role in determining the fate of Foxp3+ Tregs. In vivo, IL-4-mediated signaling via Interleukin-4 receptor alpha (IL4Rα) was convincingly shown to mediate Treg transdifferentiation into ex-Foxp3 Th2 or Th17 cells, suggesting a negative regulation of Foxp3+ Tregs by IL-4Rα-mediated signaling.

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