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Journal articles on the topic 'Interleukin-12'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

Leonard, Patricia, and Sanjiv Sur. "Interleukin-12." BioDrugs 17, no. 1 (2003): 1–7. http://dx.doi.org/10.2165/00063030-200317010-00001.

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2

&NA;. "Interleukin-12." Inpharma Weekly &NA;, no. 1124 (February 1998): 7. http://dx.doi.org/10.2165/00128413-199811240-00013.

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3

Trinchieri, Giorgio. "Interleukin-12." Clinical Immunotherapeutics 3, no. 4 (April 1995): 262–70. http://dx.doi.org/10.1007/bf03259278.

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4

Clinton, Steven K., Eduardo Canto, and Michael A. O'Donnell. "INTERLEUKIN-12." Urologic Clinics of North America 27, no. 1 (February 2000): 147–55. http://dx.doi.org/10.1016/s0094-0143(05)70242-1.

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5

Weiner, David. "Plasmid Interleukin 12." AIDS 14, no. 12 (August 2000): 1759–60. http://dx.doi.org/10.1097/00002030-200008180-00010.

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6

Leng, S. X., and J. A. Elias. "Interleukin-11 inhibits macrophage interleukin-12 production." Journal of Immunology 159, no. 5 (September 1, 1997): 2161–68. http://dx.doi.org/10.4049/jimmunol.159.5.2161.

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Abstract IL-12 is a heterodimeric cytokine produced by phagocytic and other cells with important physiologic and pathologic properties. Regulated IL-12 production is crucial for the generation of protective Th1 responses to infectious agents. In contrast, IL-12 excess contributes to the pathogenesis of a variety of autoimmune and inflammatory disorders. To further understand the processes regulating IL-12 production, we determined whether IL-11 regulated monocyte/macrophage production of this cytokine moiety. IL-11 did not alter the IL-12 (p70) production of unstimulated THP-1 monocytic cells or human blood monocytes. It did, however, inhibit, in a dose-dependent fashion, the IL-12 production of IFN-gamma plus Staphylococcus aureus Cowan strain 1-stimulated THP-1 cells and stimulated blood monocytes. This inhibition of IL-12 protein production was associated with a proportionate decrease in IL-12 p35 and p40 mRNA accumulation. Nuclear run-on assays revealed comparable decreases in IL-12 p35 and p40 gene transcription. IL-11 did not similarly regulate monocyte/macrophage production of IL-8 or macrophage inflammatory protein-1alpha (MIP-1alpha) and IL-6 did not similarly inhibit IL-12 elaboration. These studies demonstrate that IL-11 is a potent inhibitor of monocyte/macrophage IL-12 production and that this inhibitory effect is, at least in part, transcriptionally mediated. They also demonstrate that this inhibition is not the result of a generalized suppression of macrophage effector function and that the ability to inhibit monocyte/macrophage IL-12 production is not a generalized property of all IL-6-type cytokines.

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7

Fox, Robert J., and Abdolmohamad M. Rostami. "Anti???Interleukin-12 Antibody." BioDrugs 13, no. 4 (April 2000): 233–41. http://dx.doi.org/10.2165/00063030-200013040-00002.

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8

&NA;. "Interleukin-12 trial halted." Reactions Weekly &NA;, no. 556 (June 1995): 2. http://dx.doi.org/10.2165/00128415-199505560-00003.

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9

&NA;. "Interleukin-12 studies continue." Reactions Weekly &NA;, no. 558 (July 1995): 2. http://dx.doi.org/10.2165/00128415-199505580-00003.

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10

&NA;. "Interleukin-12 trial halted." Inpharma Weekly &NA;, no. 992 (June 1995): 21. http://dx.doi.org/10.2165/00128413-199509920-00047.

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11

&NA;. "Interleukin-12 studies continue." Inpharma Weekly &NA;, no. 994 (July 1995): 21. http://dx.doi.org/10.2165/00128413-199509940-00042.

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12

KATIYAR, S. "Interleukin-12 and photocarcinogenesis." Toxicology and Applied Pharmacology 224, no. 3 (November 1, 2007): 220–27. http://dx.doi.org/10.1016/j.taap.2006.11.017.

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13

Maguire, H. C. "INTERLEUKIN 12 AS IMMUNOADJUVANT." Journal of Immunotherapy 16, no. 3 (October 1994): 240. http://dx.doi.org/10.1097/00002371-199410000-00032.

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14

de Rie, M. A. "Interleukin 12 and Psoriasis." Dermatology 199, no. 2 (1999): 101. http://dx.doi.org/10.1159/000018213.

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15

Trinchieri, Giorgio, and Franca Gerosa. "Immunoregulation by interleukin-12." Journal of Leukocyte Biology 59, no. 4 (April 1996): 505–11. http://dx.doi.org/10.1002/jlb.59.4.505.

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16

Ma, X., A. D'Andrea, M. Kubin, M. Aste-Amezaga, A. Sartori, J. Monteiro, L. Showe, M. Wysocka, and G. Trinchieri. "Production of interleukin-12." Research in Immunology 146, no. 7-8 (September 1995): 432–38. http://dx.doi.org/10.1016/0923-2494(96)83012-4.

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17

Crutcher, J. M., M. M. Stevenson, M. Sedegah, and S. L. Hoffman. "Interleukin-12 and malaria." Research in Immunology 146, no. 7-8 (September 1995): 552–59. http://dx.doi.org/10.1016/0923-2494(96)83031-8.

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18

Tsai, I. San, Chi-Cheng Tsai, Ya-Ping Ho, Kun-Yen Ho, Yi-Min Wu, and Chun-Cheng Hung. "Interleukin-12 and interleukin-16 in periodontal disease." Cytokine 31, no. 1 (July 2005): 34–40. http://dx.doi.org/10.1016/j.cyto.2005.02.007.

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19

BACON, CHRIS M., SARAH S. CHO, and JOHN J. O'SHEA. "Signal Transduction by Interleukin-12 and Interleukin-2." Annals of the New York Academy of Sciences 795, no. 1 Interleukin 1 (October 1996): 41–59. http://dx.doi.org/10.1111/j.1749-6632.1996.tb52654.x.

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20

Torti, Dorothea C., and Steven R. Feldman. "Interleukin-12, interleukin-23, and psoriasis: Current prospects." Journal of the American Academy of Dermatology 57, no. 6 (December 2007): 1059–68. http://dx.doi.org/10.1016/j.jaad.2007.07.016.

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21

Sánchez, E., S. Morales, L. Paco, M. A. López-Nevot, C. Hidalgo, J. Jiménez-Alonso, B. Torres, et al. "Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus." Rheumatology 44, no. 9 (May 31, 2005): 1136–39. http://dx.doi.org/10.1093/rheumatology/keh697.

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22

Mattner, Frank, Susanne Fischer, Stefanie Guckes, Shenchu Jin, Hildegard Kaulen, Edgar Schmitt, Erwin Rüde, and Tieno Germann. "The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer." European Journal of Immunology 23, no. 9 (September 1993): 2202–8. http://dx.doi.org/10.1002/eji.1830230923.

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23

Orozco, Gisela, Miguel A. González-Gay, Laura Paco, Miguel A. López-Nevot, Manuel Guzmán, Dora Pascual-Salcedo, Alejandro Balsa, and Javier Martín. "Interleukin 12 (IL12B) and Interleukin 12 Receptor (IL12RB1) Gene Polymorphisms in Rheumatoid Arthritis." Human Immunology 66, no. 6 (June 2005): 710–14. http://dx.doi.org/10.1016/j.humimm.2005.02.004.

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24

Tahara, H., L. Zitvogel, W. J. Storkus, T. G. McKinney, P. D. Robbins, and M. T. Lotze. "CANCER GENE THERAPY USING INTERLEUKIN-12 (IL-12)." Journal of Immunotherapy 16, no. 3 (October 1994): 245. http://dx.doi.org/10.1097/00002371-199410000-00053.

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25

Lu, Zhiyu, Keye Xu, Xiaoying Wang, Yan Li, and Mingcai Li. "Interleukin 39: a new member of interleukin 12 family." Central European Journal of Immunology 45, no. 2 (2020): 214–17. http://dx.doi.org/10.5114/ceji.2020.97911.

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26

Rentzos, M., C. Nikolaou, E. Andreadou, G. P. Paraskevas, A. Rombos, M. Zoga, A. Tsoutsou, F. Boufidou, E. Kapaki, and D. Vassilopoulos. "Circulating interleukin-10 and interleukin-12 in Parkinson’s disease." Acta Neurologica Scandinavica 119, no. 5 (May 2009): 332–37. http://dx.doi.org/10.1111/j.1600-0404.2008.01103.x.

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27

&NA;. "Interleukin-12 toxicity mystery solved." Reactions Weekly &NA;, no. 580 (December 1995): 2. http://dx.doi.org/10.2165/00128415-199505800-00002.

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28

&NA;. "Interleukin-12 toxicity mystery solved." Inpharma Weekly &NA;, no. 1016 (December 1995): 21. http://dx.doi.org/10.2165/00128413-199510160-00046.

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29

Romani, L., P. Puccetti, and F. Bistoni. "Interleukin-12 in infectious diseases." Clinical Microbiology Reviews 10, no. 4 (October 1997): 611–36. http://dx.doi.org/10.1128/cmr.10.4.611.

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Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a wide range of infectious diseases. In several experimental models of bacterial, parasitic, viral, and fungal infection, endogenous IL-12 is required for early control of infection and for generation and perhaps maintenance of acquired protective immunity, directed by T helper type 1 (Th1) cells and mediated by phagocytes. Although the relative roles of IL-12 and gamma interferon in Th1-cell priming may be to a significant extent pathogen dependent, common to most infections is that IL-12 regulates the magnitude of the gamma interferon response at the initiation of infection, thus potentiating natural resistance, favoring Th1-cell development; and inhibiting Th2 responses. Treatment of animals with IL-12, either alone or as a vaccine adjuvant, has been shown to prevent disease by many of the same infectious agents, by stimulating innate resistance or promoting specific reactivity. Although IL-12 may enhance protective memory responses in vaccination or in combination with antimicrobial chemotherapy, it is yet unclear whether exogenous IL-12 can alter established responses in humans. Continued investigation into the possible application of IL-12 therapy to human infections is warranted by the role of the cytokine in inflammation, immunopathology, and autoimmunity.

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30

Romani, L., P. Puccetti, and F. Bistoni. "Interleukin-12 in infectious diseases." Clinical microbiology reviews 10, no. 4 (1997): 611–36. http://dx.doi.org/10.1128/cmr.10.4.611-636.1997.

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31

Bashyam, Hema. "Interleukin-12: A master regulator." Journal of Experimental Medicine 204, no. 5 (May 7, 2007): 969. http://dx.doi.org/10.1084/jem.2045fta.

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Early resistance to pathogens requires a swift response from NK cells. In 1989, Giorgio Trinchieri identified an NK growth factor and activator, later called interleukin-12 (IL-12). This discovery helped reveal the regulatory link between innate and adaptive immunity.

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32

Adorini, Luciano. "Interleukin 12 and autoimmune diabetes." Nature Genetics 27, no. 2 (February 2001): 131–32. http://dx.doi.org/10.1038/84732.

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33

Sacks, G. P., D. Scott, H. Tivnann, T. Mire-Sluis, I. L. Sargent, and C. W. G. Redman. "Interleukin-12 and pre-eclampsia." Journal of Reproductive Immunology 34, no. 2 (September 1997): 155–58. http://dx.doi.org/10.1016/s0165-0378(97)00028-4.

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34

Bryan, Dani-Louise, Joanna S. Hawkes, and Robert A. Gibson. "Interleukin-12 in Human Milk." Pediatric Research 45, no. 6 (June 1999): 858–59. http://dx.doi.org/10.1203/00006450-199906000-00013.

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35

Sturmhoefel, K., K. Lee, M. O. Toole, H. M. Swiniarski, A. J. Dorner, and S. F. Wolf(xc*). "Interleukin 12 as vaccine adjuvant." Research in Immunology 149, no. 1 (January 1998): 37–39. http://dx.doi.org/10.1016/s0923-2494(98)80041-2.

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36

Rowe, PaulM. "Cautious optimism over interleukin-12." Lancet 345, no. 8962 (June 1995): 1432. http://dx.doi.org/10.1016/s0140-6736(95)92618-6.

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37

Trinchieri, Giorgio, Manthrasalam Rengaraju, Annalisa D'Andrea, Nicholas M. Valiante, Marek Kubin, Miguel Aste, and Jihed Chehimi. "Producer cells of interleukin-12." Immunology Today 14, no. 5 (May 1993): 237–38. http://dx.doi.org/10.1016/0167-5699(93)90173-i.

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38

MA, XIAOJING, MIGUEL ASTE-AMEZAGA, and GIORGIO TRINCHIERI. "Regulation of Interleukin-12 Production." Annals of the New York Academy of Sciences 795, no. 1 Interleukin 1 (October 1996): 13–25. http://dx.doi.org/10.1111/j.1749-6632.1996.tb52651.x.

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39

BLISS, JUDY, RICHARD MAYLOR, KEYA STOKES, KRISTIN S. MURRAY, MARA A. KETCHUM, and STANLEY F. WOLF. "Interleukin-12 as Vaccine Adjuvant." Annals of the New York Academy of Sciences 795, no. 1 Interleukin 1 (October 1996): 26–35. http://dx.doi.org/10.1111/j.1749-6632.1996.tb52652.x.

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40

Brunda, Michael J., and Maurice K. Gately. "Antitumor Activity of Interleukin-12." Clinical Immunology and Immunopathology 71, no. 3 (June 1994): 253–55. http://dx.doi.org/10.1006/clin.1994.1081.

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41

Karp, Christopher L. "Interleukin-12: Amiss in MS." Annals of Neurology 45, no. 6 (June 1999): 689–92. http://dx.doi.org/10.1002/1531-8249(199906)45:6<689::aid-ana1>3.0.co;2-m.

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42

Podlaski, Frank J., Venkata B. Nanduri, Jeffrey D. Hulmes, Yu-Ching E. Pan, Wayne Levin, Waleed Danho, Richard Chizzonite, Maurice K. Gately, and Alvin S. Stern. "Molecular characterization of interleukin 12." Archives of Biochemistry and Biophysics 294, no. 1 (April 1992): 230–37. http://dx.doi.org/10.1016/0003-9861(92)90162-p.

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43

Trinchieri, Giorgio, Manthrasalam Rengaraju, Annalisa D'Andrea, Nicholas M. Valiante, Marek Kubin, Miguel Aste, and Jihed Chehimi. "Producer cells of interleukin 12." Parasitology Today 9, no. 3 (March 1993): 97. http://dx.doi.org/10.1016/0169-4758(93)90215-2.

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44

Gately, Maurice K., Louis M. Renzetti, Jeanne Magram, Alvin S. Stern, Luciano Adorini, Ueli Gubler, and David H. Presky. "THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses." Annual Review of Immunology 16, no. 1 (April 1998): 495–521. http://dx.doi.org/10.1146/annurev.immunol.16.1.495.

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45

Wang, Xin, Victoria L. Wilkinson, Frank J. Podlaski, Chang-you Wu, Alvin S. Stern, David H. Presky, and Jeanne Magram. "Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits." European Journal of Immunology 29, no. 6 (June 1999): 2007–13. http://dx.doi.org/10.1002/(sici)1521-4141(199906)29:06<2007::aid-immu2007>3.0.co;2-0.

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46

Yücel, Özlem Özer, Ezel Berker, Semra Gariboğlu, and Harika Otlu. "Interleukin-11, interleukin-1β, interleukin-12 and the pathogenesis of inflammatory periodontal diseases." Journal of Clinical Periodontology 35, no. 5 (May 2008): 365–70. http://dx.doi.org/10.1111/j.1600-051x.2008.01212.x.

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47

GATELY, MAURICE K., DAISY M. CARVAJAL, SUZANNE E. CONNAUGHTON, SILKE GILLESSEN, RAJEEV R. WARRIER, KENNETH D. KOLINSKY, VICTORIA L. WILKINSON, et al. "Interleukin-12 Antagonist Activity of Mouse Interleukin-12 p40 Homodimer in Vitro and in Vivo." Annals of the New York Academy of Sciences 795, no. 1 Interleukin 1 (October 1996): 1–12. http://dx.doi.org/10.1111/j.1749-6632.1996.tb52650.x.

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48

Robinson, Cory M., and Gerard J. Nau. "Interleukin‐12 and Interleukin‐27 Regulate Macrophage Control ofMycobacterium tuberculosis." Journal of Infectious Diseases 198, no. 3 (August 2008): 359–66. http://dx.doi.org/10.1086/589774.

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49

Kovarik, Johannes J., Elisabeth Kernbauer, Markus A. Hölzl, Johannes Hofer, Guido A. Gualdoni, Klaus G. Schmetterer, Fitore Miftari, et al. "Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis." PLOS ONE 12, no. 7 (July 24, 2017): e0180900. http://dx.doi.org/10.1371/journal.pone.0180900.

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50

El-Shabrawi, Y. "Interleukin-12 und Interleukin-10 in intraokulären Flüssigkeiten von Uveitispatienten." Spektrum der Augenheilkunde 13, no. 1 (February 1999): 1–5. http://dx.doi.org/10.1007/bf03162708.

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