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Academic literature on the topic 'Interindividual difference'

Author: Grafiati

Published: 10 March 2023

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Journal articles on the topic "Interindividual difference"

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Boobis, Alan R., Nigel J. Gooderham, Robert J. Edwards, and Donald S. Davies. "Isozymle and interindividual difference in human metabollsm of heterocyclle aminee." Toxicology Letters 78 (August 1995): 4. http://dx.doi.org/10.1016/0378-4274(95)94611-j.

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Ambrosini, Ettore, and Antonino Vallesi. "Domain-general Stroop Performance and Hemispheric Asymmetries: A Resting-state EEG Study." Journal of Cognitive Neuroscience 29, no. 5 (May 2017): 769–79. http://dx.doi.org/10.1162/jocn_a_01076.

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The ability to suppress irrelevant information while executing a task, also known as interference resistance ability, is a function of pFC that is critical for successful goal-directed human behavior. In the study of interference resistance and, more generally, executive functions, two key questions are still open: Does pFC contribute to cognitive control abilities through lateralized but domain-general mechanisms or through hemispheric specialization of domain-specific processes? And what are the underlying causes of interindividual differences in executive control performance? To shed light on these issues, here we employed an interindividual difference approach to investigate whether participants' hemispheric asymmetry in resting-state electrophysiological brain dynamics may reflect their variability in domain-general interference resistance. We recorded participants' resting-state electroencephalographic activity and performed spectral power analyses on the estimated cortical source activity. To measure participants' lateralized brain dynamics at rest, we computed the right–left hemispheric asymmetry score for the β/α power ratio. To measure their domain-general interference resistance ability, verbal and spatial Stroop tasks were used. Robust correlations followed by intersection analyses showed that participants with stronger resting-state-related left-lateralized activity in different pFC regions, namely the mid-posterior superior frontal gyrus, middle and posterior middle frontal gyrus, and inferior frontal junction, were more able to inhibit irrelevant information in both domains. The present results confirm and extend previous findings showing that neurophysiological difference factors may explain interindividual differences in executive functioning. They also provide support for the hypothesis of a left pFC hemispheric specialization for domain-independent phasic cognitive control processes mediating Stroop performance.

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Hayashi, Shin-ichi, Junko Watanabe, Kei Nakachi, Hidetaka Eguchi, Osamu Gotoh, and kaname Kawajiri. "Interindividual difference in expression of human Ah receptor and related P450 genes." Carcinogenesis 15, no. 5 (1994): 801–6. http://dx.doi.org/10.1093/carcin/15.5.801.

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Miura, M., T. Niioka, H. Kagaya, M. Saito, M. Hayakari, T. Habuchi, and S. Satoh. "Pharmacogenetic determinants for interindividual difference of tacrolimus pharmacokinetics 1 year after renal transplantation." Journal of Clinical Pharmacy and Therapeutics 36, no. 2 (March 1, 2011): 208–16. http://dx.doi.org/10.1111/j.1365-2710.2010.01163.x.

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Ito, Shin-ichi, Yasue Mitsukura, Katsuya Sato, Shoichiro Fujisawa, and Minoru Fukumi. "Interindividual Difference Analysis in Prefrontal Cortex EEGs Based on the Relationship with Personality." Journal of Signal Processing 16, no. 5 (2012): 443–50. http://dx.doi.org/10.2299/jsp.16.443.

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Fiamoncini, Jarlei, Andrianos M. Yiorkas, Kurt Gedrich, Milena Rundle, Sanne I. Alsters, Guus Roeselers, Tim J. van den Broek, et al. "Determinants of postprandial plasma bile acid kinetics in human volunteers." American Journal of Physiology-Gastrointestinal and Liver Physiology 313, no. 4 (October 1, 2017): G300—G312. http://dx.doi.org/10.1152/ajpgi.00157.2017.

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Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women ( n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention. BA were quantified in plasma by liquid chromatography-tandem mass spectrometry combined with whole genome exome sequencing and fecal microbiota profiling. Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma BA profiles. Fasting and postprandial BA profiles revealed high interindividual variability, and three main patterns in postprandial BA response were identified using multivariate analysis. Although the women enrolled were postmenopausal, effects of sex difference in BA response were evident. Exome data revealed the contribution of preselected genes to the observed interindividual variability. In particular, a variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases. Fecal microbiota analysis did not reveal evidence for a significant influence of bacterial diversity and/or composition on plasma BA profiles. The analysis of plasma BA profiles in response to two different dietary challenges revealed a high interindividual variability, which was mainly determined by genetics and sex difference of host with minimal effects of the microbiota. NEW & NOTEWORTHY Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma bile acid (BA) profiles. Despite high interindividual variability, three main patterns in postprandial BA response were identified using multivariate analysis. A variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases in response to both the oral glucose tolerance test and the mixed-meal tolerance test.

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Nishioka, Alessandra, Eric de Castro Tobaruela, Layanne Nascimento Fraga, Francisco A. Tomás-Barberán, Franco Maria Lajolo, and Neuza Mariko Aymoto Hassimotto. "Stratification of Volunteers According to Flavanone Metabolite Excretion and Phase II Metabolism Profile after Single Doses of ‘Pera’ Orange and ‘Moro’ Blood Orange Juices." Nutrients 13, no. 2 (January 30, 2021): 473. http://dx.doi.org/10.3390/nu13020473.

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Large interindividual variations in the biological response to citrus flavanones have been observed, and this could be associated with high variations in their bioavailability. The aim of this study was to identify the main determinants underlying interindividual differences in citrus flavanone metabolism and excretion. In a randomized cross-over study, non-obese and obese volunteers, aged 19–40 years, ingested single doses of Pera and Moro orange juices, and urine was collected for 24 h. A large difference in the recovery of the urinary flavanone phase II metabolites was observed, with hesperetin-sulfate and hesperetin-sulfo-O-glucuronide being the major metabolites. Subjects were stratified according to their total excretion of flavanone metabolites as high, medium, and low excretors, but the expected correlation with the microbiome was not observed at the genus level. A second stratification was proposed according to phase II flavanone metabolism, whereby participants were divided into two excretion groups: Profiles A and B. Profile B individuals showed greater biotransformation of hesperetin-sulfate to hesperetin-sulfo-O-glucuronide, as well as transformation of flavanone-monoglucuronide to the respective diglucuronides, suggestive of an influence of polymorphisms on UDP-glucuronosyltransferase. In conclusion, this study proposes a new stratification of volunteers based on their metabolic profiles. Gut microbiota composition and polymorphisms of phase II enzymes may be related to the interindividual variability of metabolism.

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Brothers, R. Matthew, David M. Keller, Jonathan E. Wingo, Matthew S. Ganio, and Craig G. Crandall. "Heat-stress-induced changes in central venous pressure do not explain interindividual differences in orthostatic tolerance during heat stress." Journal of Applied Physiology 110, no. 5 (May 2011): 1283–89. http://dx.doi.org/10.1152/japplphysiol.00035.2011.

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The extent to which heat stress compromises blood pressure control is variable among individuals, with some individuals becoming very intolerant to a hypotensive challenge, such as lower body negative pressure (LBNP) while heat stressed, while others are relatively tolerant. Heat stress itself reduces indexes of ventricular filling pressure, including central venous pressure, which may be reflective of reductions in tolerance in this thermal condition. This study tested the hypothesis that the magnitude of the reduction in central venous pressure in response to heat stress alone is related to the subsequent decrement in LBNP tolerance. In 19 subjects, central hypovolemia was imposed via LBNP to presyncope in both normothermic and heat-stress conditions. Tolerance to LBNP was quantified using a cumulative stress index (CSI), and the difference between normothermic CSI and heat-stress CSI was calculated for each individual. The eight individuals with the greatest CSI difference between normothermic and heat-stress tolerances (LargeDif), and the eight individuals with the smallest CSI difference (SmallDif), were grouped together. By design, the difference in CSI between thermal conditions was greater in the LargeDif group (969 vs. 382 mmHg × min; P < 0.001). Despite this profound difference in the effect of heat stress in decreasing LBNP tolerance between groups, coupled with no difference in the rise in core body temperatures to the heat stress (LargeDif, 1.4 ± 0.1°C vs. SmallDif, 1.4 ± 0.1°C; interaction P = 0.89), the reduction in central venous pressure during heat stress alone was similar between groups (LargeDif: 5.7 ± 1.9 mmHg vs. SmallDif: 5.2 ± 2.0 mmHg; interaction P = 0.85). Contrary to the proposed hypothesis, differences in blood pressure control during LBNP are not related to differences in the magnitude of the heat-stress-induced reductions in central venous pressure.

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Sakata, Seiichiro, Junichiro Hayano, Seiji Mukai, Akiyoshi Okada, and Takao Fujinami. "Aging and spectral characteristics of the nonharmonic component of 24-h heart rate variability." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 6 (June 1, 1999): R1724—R1731. http://dx.doi.org/10.1152/ajpregu.1999.276.6.r1724.

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To examine whether heart rate variability (HRV) during daily life shows power law behavior independently of age and interindividual difference in the total power, log-log scaled coarse-graining spectra of the nonharmonic component of 24-h HRV were studied in 62 healthy men (age 21–79 yr). The spectra declined with increasing frequency in all subjects, but they appeared as broken lines slightly bending downward, particularly in young subjects with a large total power. Regression of the spectrum by a broken line with a single break point revealed that the spectral exponent (β) was greater in the region below than above the break point (1.63 ± 0.23 vs. 0.96 ± 0.21, P < 0.001). The break point frequency increased with age ( r = 0.51, P < 0.001) and β correlated with age negatively below the break point ( r = 0.39) and positively above the break point ( r = 0.70). The contribution to interindividual difference in total power was greater from the differences in the power spectral density at frequencies closer to both ends of the frequency axis and minimal from that at −3.25 log(Hz), suggesting hingelike movement of the spectral shape at this frequency with the difference in total power. These characteristics of the 24-h HRV spectrum were simulated by an artificial signal generated by adding two noises with different β values. Given that the power law assumption is fundamental to the analysis of dynamics through the log-log scaled spectrum, our observations are substantial for physiological and clinical studies of the heartbeat dynamic during daily life and suggest that the nonharmonic component of HRV in normal subjects during daily life may include at least two 1/ f β fluctuations that differ in dynamics and age dependency.

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He, Ruo-Hui, Yi-Jing He, Yong-Jun Tang, Hong-Hao Zhou, Howard L. McLeod, and Jie Liu. "The potential anticancer effect of beta-blockers and the genetic variations involved in the interindividual difference." Pharmacogenomics 17, no. 1 (January 2016): 74–9. http://dx.doi.org/10.2217/pgs.15.152.

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Dissertations / Theses on the topic "Interindividual difference"

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McLellan, Roman A. "Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3924-1/.

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Raufelder, Diana [Verfasser]. "Social Relationships and Motivation in Secondary Schools: Interindividual Differences / Diana Raufelder." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1046833014/34.

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Haglund, Sofie. "Interindividual differences in thiopurine metabolism : studies with focus on inflammatory bowel disease." Doctoral thesis, Linköpings universitet, Gastroenterologi och hepatologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66434.

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The thiopurines, 6-mercaptopurine and its prodrug azathioprine, are used in the treatment of inflammatory bowel disease, ulcerative colitis and Crohn´s disease. The main active metabolites are the phosphorylated thioguanine nucleotides (6-TGNs) and methylated thioinosine monophosphate (meTIMP). Both groups contribute to the immunomodulatory effects. About 30-40% of patients fail to benefit from thiopurine treatment. A well-known cause of adverse reactions is decreased or absent thiopurine S-methyltransferase (TPMT) activity. Low TPMT activity is inherited as an autosomal codominant recessive trait and is present in approximately 10% of the population. Although several clinical issues can be solved from determination of TPMT activity, there are cases where it is not possible. In Sweden approximately 25% of IBD-patients display suboptimal 6-TGN concentrations and unexpectedly high concentrations of meTIMP despite a normal TPMT activity. A high meTIMP/6-TGN concentration ratio has been associated with both unresponsiveness to therapy and emergence of adverse reactions. Inosine 5’-monophosphate dehydrogenase (IMPDH) may constitute a candidate gene to explain this metabolite profile, as it is strategically positioned in the metabolic pathway of thiopurines where it competes with TPMT for their common substrate 6-TIMP. In paper I a pyrosequencing method was developed for genotyping of at that time all known genetic variants of TPMT. The concordance between genotype and phenotype in 30 individuals was 93%. The allele frequencies of TPMT*3A, *3B, *3C and *2 in a Swedish background population (n=800) were in agreement with those in other Caucasian or European populations. In Paper II-IV we explored the molecular basis of different metabolite profiles, i.e. low, normal and high meTIMP/6-TGN concentration ratios. The activity of IMPDH was measured in mononuclear cells (MNC). Patients with high metabolite ratios had lower IMPDH activity than patients with normal or low ratios, explained by an inverse correlation to red blood cells concentration of meTIMP. No correlation to 6-TGN was observed. Downregulation of IMPDH activity in HEK293 cells with genetically engineered TPMT activity was associated with an increase in meTIMP, but unexpectedly also of 6-TGN, irrespective of the TPMT status. These results suggest effects of pharmacogenes other than TPMT and IMPDH. A whole genome expression analysis was performed, (1) to identify new candidate genes that could explain differences in metabolite profiles, and (2) to study genes with known associations to the metabolic pathway of (thio)purines. The whole genome expression analysis did not identify any significant group differences. In analysis of the thiopurine related genes, three clusters of co-regulated genes were defined. A co-operation between expression levels of SLC29A1 and NT5E in explaining the meTIMP/6-TGN concentration ratio was observed, and individually SLC29A1 and NT5E correlated to 6-TGN and meTIMP, respectively. Pysosequencing is a convenient and flexible method which is now run in parallel to phenotyping in our laboratory. Our results also illustrate the complexity of the thiopurine metabolism and suggest that differences between metabolite profiles are explained either by interactions between several genes, each with a small contribution, or at the post-transcriptional level. Search for more precise tools to explain differences in metabolite profiles is needed. Furthermore, in order to investigate small effects it is necessary to analyse metabolite concentrations and gene expression levels, as well as enzyme activities in the target cells of therapy (MNC).

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Yaşar, Ümit. "Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-131-4/.

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Rodehacke, Sarah, Eva Mennigen, Kathrin U. Müller, Stephan Ripke, Mark J. Jacob, Thomas Hübner, Dirk H. K. Schmidt, Thomas Goschke, and Michael N. Smolka. "Interindividual Differences in Mid-Adolescents in Error Monitoring and Post-Error Adjustment." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-147418.

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A number of studies have concluded that cognitive control is not fully established until late adolescence. The precise differences in brain function between adults and adolescents with respect to cognitive control, however, remain unclear. To address this issue, we conducted a study in which 185 adolescents (mean age (SD) 14.6 (0.3) years) and 28 adults (mean age (SD) 25.2 (6.3) years) performed a single task that included both a stimulus-response (S-R) interference component and a task-switching component. Behavioural responses (i.e. reaction time, RT; error rate, ER) and brain activity during correct, error and post-error trials, detected by functional magnetic resonance imaging (fMRI), were measured. Behaviourally, RT and ER were significantly higher in incongruent than in congruent trials and in switch than in repeat trials. The two groups did not differ in RT during correct trials, but adolescents had a significantly higher ER than adults. In line with similar RTs, brain responses during correct trials did not differ between groups, indicating that adolescents and adults engage the same cognitive control network to successfully overcome S-R interference or task switches. Interestingly, adolescents with stronger brain activation in the bilateral insulae during error trials and in fronto-parietal regions of the cognitive control network during post-error trials did have lower ERs. This indicates that those mid-adolescents who commit fewer errors are better at monitoring their performance, and after detecting errors are more capable of flexibly allocating further cognitive control resources. Although we did not detect a convincing neural correlate of the observed behavioural differences between adolescents and adults, the revealed interindividual differences in adolescents might at least in part be due to brain development.

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Green, Henrik. "Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8134.

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Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. The response to treatment and the severity of adverse drug reactions after chemotherapy varies greatly among individuals, and one of the most important factors responsible for these differences is now recognized to be the genetic variability. One of the major obstacles to successful treatment is drug resistance. Several potential mechanisms have been suggested for the resistance to paclitaxel, such as mutations in the target protein β-tubulin, single nucleotide polymorphisms (SNPs) in the gene ABCB1, which encodes the transport protein P-glycoprotein. P-glycoprotein can mediate efflux of various drugs from cancer cells as well as from the circulation into the intestinal lumen, and overexpression and/or high activity leads to drug resistance and/or increased elimination. Another reason might be the high interindividual variability of paclitaxel plasma concentrations, which has been suggested to be influenced by variability in metabolic enzymes, such as CYP2C8 and CYP3A4, and transport proteins e.g. P-glycoprotein. In the studies constituting this thesis we have investigated the possibilities of predicting the pharmacokinetics of paclitaxel as well as the tumor response and adverse drug reactions after chemotherapy in the preparation of personalized chemotherapy. We studied the correlation between the response and the presence of mutations in the dominant β-tubulin gene and SNPs in ABCB1. DNA from 40 ovarian tumors was screened for sequence variations in the β-tubulin gene without finding any, showing that β-tubulin mutations are rare and unlikely to be a clinically relevant resistance mechanism for paclitaxel. The SNPs G2677T/A and C3435T in the ABCB1 gene were determined in 53 ovarian cancer tumors from patients with poor (progressive disease or relapse within one year) or good (disease-free survival of more than one year) response to paclitaxel-carboplatin chemotherapy. Patients homozygously mutated for G2677T/A had a higher probability of responding to chemotherapy. There was also a dose-dependent influence of the number of mutated alleles on the response to paclitaxel treatment. No correlation was found for the C3435T variant. By using a newly developed quantitative LC/MS method for the simultaneous determination of paclitaxel and its hydroxymetabolites in human plasma we assessed the individual elimination of paclitaxel in 33 ovarian cancer patients. The patients were genotyped for SNPs in the ABCB1, CYP2C8 and CYP3A4 genes and their in vivo CYP3A4 enzyme activity, tumor response and toxicity, especially the neurotoxicity, were determined. Patients heterozygous for G/A in position 2677 in ABCB1 had a significantly higher clearance of paclitaxel than patients with the wild type or homozygously mutated, but not compared to patients carrying the G/T alleles. A lower clearance of paclitaxel was also found for patients heterozygous for CYP2C8*3 when stratified according to the ABCB1 G2677T/A genotype. The CYP3A4 enzyme activity in vivo affected the relative influence of CYP2C8 and CYP3A4 on the metabolism, but not the total clearance of paclitaxel. The exposure to paclitaxel was correlated to the neurotoxicity, but not to the treatment response. In conclusion, our findings suggest that the SNP G2677T/A in the ABCB1 gene, but not β-tubulin mutations, might be a predictor for paclitaxel response and that the interindividual variability in paclitaxel pharmacokinetics might be predicted by ABCB1 and CYP2C8 genotypes and provide useful information for individualized chemotherapy.
Ovarialcancer (äggstockscancer) är en av de vanligaste cancerformerna hos kvinnor i Sverige idag. Behandlingen består vanligen av tumörreducerande kirurgi följd av kemoterapi med paklitaxel och karboplatin. Målsättningen med detta avhandlingsarbete har varit att förbättra cytostatikabehandlingen (cellgiftsbehandlingen) med framförallt paklitaxel vid ovarialcancer genom att lägga grunden för individualisering av doser och förutsäga tumörsvaret vid behandlingen. Ett problem med dagens cancerbehandling är att många cancerceller så småningom blir resistenta mot olika cytostatika. För att angripa den mest resistenta cellen innan den induceras att öka uttrycket av, eller utveckla, fler resistensmekanismer vore det en fördel om vi före behandlingen kunde prediktera vilken dos av cytostatika som är bäst lämpad för individen samt om tumören kommer att reagera på behandlingen eller ej. En av de viktigaste faktorerna för skillnader i behandlingseffekt tros vara genetiska variationer mellan olika individer. I våra studier har vi använt genetiska metoder för att studera om vi kan prediktera tumörsvaret vid behandlingen genom att bestämma mutationer i genen för paklitaxels målprotein, β-tubulin, samt bestämma genetiska variationer i ABCB1-genen, kodande för transportproteinet P-glykoprotein. Tanken är att ett förändrat målprotein eller en förändrad förmåga hos cancercellerna eller kroppen att transportera ut paklitaxel skulle leda till en skillnad i påverkan på tumören. DNA från 40 ovarialtumörer analyserades utan att en enda sekvensvariation hittades i genen för β-tubulin, vilket tyder på att genetiska förändringar i genen för β-tubulin sannolikt inte är en klinisk relevant resistensmekanism. De normalt förekommande genetiska variationerna G2677T/A och C3435T i ABCB1-genen bestämdes i DNA från 53 ovarialtumörer där behandlingen endera givit en bra (tumörfri minst ett år) eller dålig (progression av tumören eller tumörfri mindre än ett år) anti-tumöreffekt. Patienter som var dubbelmuterade i position 2677 dvs hade endera T/T eller T/A (A/A hittades inte i materialet) i denna position hade en högre sannolikhet att få ett bra anti-tumörsvar vid behandlingen. Även antalet muterade baser påverkade utfallet, ju fler muterade baser i position 2677, desto högre sannolikhet att få ett bra svar på behandlingen. Andelen T eller A var också högre i den grupp av patienter som fått en lyckad behandling. För att kunna prediktera patientens individuella förmåga att bryta ner paklitaxel studerade vi inverkan av sekvensvariationer i generna för de nedbrytande enzymerna, CYP2C8 och CYP3A4, och transportproteinet P-glykoprotein (genen ABCB1) på eliminationen av läkemedlet i kroppen. Vi utvecklade en metod för att mäta paklitaxelkoncentrationerna i blodet och använde den för att studera hur snabbt 33 ovarialcancer patienter eliminerade cytostatikat från blodbanan. Hos dessa patienter bestämde vi förekomsten av kända genetiska variationer i generna ABCB1, CYP2C8 och CYP3A4 samt deras CYP3A4 enzymaktivitet i kroppen. Biverkningarna och tumörsvaret vid behandlingen utvärderades också. Eliminationen av paklitaxel hos dessa patienter var beroende av vilken bas som fanns i position 2677 i ABCB1-genen och förekomsten av den genetiska varianten CYP2C8*3. Enzymaktiviteten hos CYP3A4 kunde inte påvisas påverka eliminationen av paklitaxel utan snarare vilket enzym, CYP2C8 eller CYP3A4, som var relativt dominant i respektive patient. Exponeringen av paklitaxel korrelerade till den neurologiska påverkan som patienten orsakades av cytostatikat, men kunde inte korreleras till tumörsvaret vid slutet av cytostatikabehandlingen. Sammanfattningsvis ger patientens genetiska variationer i ABCB1, men inte β-tubulin, information om behandlingsutfallet. Genetiska variationer i CYP2C8 och ABCB1 påverkar patientens förmåga att eliminera paklitaxel och kan förhoppningsvis användas för att individualisera doserna. Vår förhoppning är att resultaten i denna avhandling skall kunna användas för att individualisera och ytterligare förbättra cytostatikabehandlingen vid ovarialcancer.

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Gréen, Henrik. "Pharmacogenetic studies of paclitaxel in ovarian cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics /." Linköping : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8134.

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Titt, Raphael [Verfasser]. "Investigating the attitude towards ambiguity : Interindividual differences in automatic activations of evaluations of ambiguity / Raphael Titt." Tübingen : Universitätsbibliothek Tübingen, 2021. http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1192903.

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Planas-Sitjà, Isaac. "Quantification and determination of the interindividual variability observed in a group of cockroaches and its implications at a collective level." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/249175.

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In this thesis, we used the American cockroach study the relationship between animal personality and collective behaviour. These questions do not only regard domiciliary cockroaches or insects; in fact, the questions we discuss here have a large scope and concern most of the known gregarious species distributed in several taxa. One of our aims is to develop general tools, methods and analyses that could be used for the study of collective behaviour.We show evidence of personality in several behavioural traits and different contexts in the American cockroach. These behavioural differences were observed in a context without social interactions during the daytime (isolated condition) and nighttime (solitary exploration behaviour) and in a social context (rate of joining a shelter and sheltering time). Based on the short-term experiments, this personality can be understood as differences in the probability of joining a shelter. We show that the behavioural variability existing in a population of domiciliary cockroaches is very high. The composition of personalities within a group can lead to group personality – consistent differences in group behaviour. For instance, groups composed of different behavioural profiles show different collective dynamics. Regarding the long-term experiments, our results show that the individuals that were aggregated at a site that was repeatedly disturbed by a lighting stimulus during their resting period showed slow migration to a new shelter, which allowed the initial aggregation site to remain the site of choice for a few days. Moreover, the disturbance regime did not influence the group's global activity rhythm. At the individual level, we observed interindividual differences (personalities) in terms of their position prior to the disturbance but not for the different steps of the fleeing behaviour itself. In addition, we show that thigmotaxis affects the reaction time to the disturbance: individuals near the walls of the shelter react more slowly thanindividuals in the centre. Finally, an approach coupling modelling and experimental data shows that behavioural variability plays a secondary role during migration dynamics, thus highlighting the plasticity of personality traits depending on the context.
Un des comportements collectifs les plus répandus, qu’il s’agisse de vertébrés (mammifères, oiseaux, poissons), d’insectes ou encore de bactéries, est la tendance des individus à se regrouper. Les causes proximales de ces rassemblements ou agrégats, c'est-à-dire les mécanismes à leur origine, ont retenu moins d’attention que l’étude des causes ultimes. De plus, dans la plupart des études portant sur les processus d’agrégation, notamment chez notre organisme modèle, la blatte, la diversité des comportements individuels est souvent sous-estimée ou ignorée. L’objectif de cette thèse est l’étude du rôle des différences interindividuelles, également connues comme personnalité animale ou syndromes comportementales, dans les processus de prise de décision collective et notamment la formation des agrégats.Pour cela, nous avons utilisé des groupes de mâles de la blatte américaine Periplaneta americana. Ces insectes peuvent s’agréger dans un ou plusieurs abris et présenter des différences dans leur réponse au milieu, aux conspécifiques et dans le partage de l’information. Dans le cadre de prises de décisions collectives, nous avons mis en évidence une personnalité individuelle mais également au niveau du groupe. Celles-ci se manifestent dans la recherche d’un abri dont certains individus jouent un rôle clef. Nous avons montré que les groupes présentent une stabilité qui est observable au niveau de la dynamique d'agrégation et qui dépend de la distribution des personnalités au sein de ceux-ci. De plus, nous remarquons que ces différences de personnalités au sein des groupes affectent la prise de décision collective, notamment la vitesse du choix et le nombre total d’individus abrités. De manière surprenante, la composition des groupes n’affecte pas la probabilité que ceux-ci atteignent un consensus: la majorité des blattes étant agrégées sous le même abri.Concernant les influences croisées entre l’effet sociale et la personnalité des blattes, nous montrons que les effets sociaux tendent à supprimer les différences inter-individuelles et créent une corrélation entre le comportement de chaque individu et le comportement du groupe. De plus, nous observons que la présence de différentes personnalités dans un groupe augmente les amplifications sociales, celles-ci étant dues aux interactions entre les membres du groupe. Finalement, nous abordons la question du rôle de la personnalité sur le comportement de fuite lors des perturbations lumineuses et sur la dynamique d’émigration quand le site de repos est régulièrement perturbé. Nous avons montré l’existence de personnalités exprimées pendant la phase active nocturne et de différences interindividuelles au niveau du thigmotactisme pendant la journée (phase passive de repos et d’agrégation). Curieusement, ces différences inter-individuelles ne sont pas observées lors du comportement de fuite et au niveau de la dynamique global d’émigration. Dans la dernière partie de notre thèse, nous discutons, en particulier, des synergies et des conflits entre les différentes personnalités et les dynamiques collectives et avançons l’hypothèse que les phénomènes que nous avons mis en évidence sont partagés par de nombreuses espèces grégaires.
Doctorat en Sciences
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Große, Rüschkamp Johanna Marie. "Short-Term Changes in Positive Affective Experiences and their Relation to Interindividual Differences in Subjective Well-Being: A Multimethod Approach." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20390.

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Personen unterscheiden sich in dem, wie sie sich im Allgemeinen fühlen. Das Ziel dieser Dissertation ist es, die Prozesse, die diesen Personenunterschieden zugrunde liegen, zu verstehen. Es wurden insbesondere die affektiven Prozesse affektive Reaktivität und Emotionsregulation untersucht. In drei Studien wurden die folgenden Forschungsfragen untersucht: (1) Haben Personen mit höherem subjektiven Wohlbefinden einen stärkeren Anstieg in positivem Affekt, wenn sie auf positive Stimuli im Labor reagieren oder ihre positiven Emotionen hochregulieren? (2) Welches sind die neuronalen Korrelate, die diesen kurzfristigen Veränderungen in positivem Affekt zugrunde liegen, insbesondere während der Hochregulation positiver Emotionen? (3) Hängt ein höheres subjektives Wohlbefinden mit einer stärkeren oder geringeren Reaktion auf positive Ereignisse im Alltag zusammen? Die Befunde haben gezeigt, dass ein stärkerer Anstieg in positivem Affekt (durch eine stärkere Reaktion auf positive Ereignisse oder durch das Hochregulieren positiver Emotionen) nicht mit einem höheren subjektiven Wohlbefinden zusammenhängt. Stattdessen hatten Personen mit einem höheren subjektiven Wohlbefinden eine geringere Reaktivität auf positive Ereignisse im Alltag. Auf der neuronalen Ebene spiegelten sich die Veränderungen in positivem Affekt durch eine verstärkte neuronale Aktivierung in emotionsbezogenen Regionen (insbesondere des ventralen Striatums) wieder, sowie durch eine Deaktivierung in einem fronto-parietalen Kontrollnetzwerk. Ein Zusammenhang von neuronaler Aktivierung und Veränderungen in positivem Affekt im Alltag wurde nicht gefunden. Die Arbeit dieser Dissertation zeigt, dass nicht besonders intensives positives Erleben, sondern eher weniger Schwankungen in momentanen positiven Affekt wichtig für das Wohlbefinden sind. Darüber hinaus zeigt diese Dissertation die Wichtigkeit auf verschiedene Analyseebenen und Untersuchungsmethoden in die Erforschung von affektivem Erleben zu integrieren.
This dissertation investigates the affective processes – affective reactivity and emotion regulation – underlying short-term changes in positive affective experiences and their relation to interindividual differences in subjective well-being. The main research objectives that were addressed in the empirical studies of this dissertation concerned (1) whether stronger increases in positive affect when reacting to and when up-regulating in response to positive stimuli in the laboratory relate to higher subjective well-being, (2) which brain regions underlie changes in positive affective experiences, particularly during the up-regulation of positive emotions, and (3) whether enhanced or reduced affective reactivity to positive events in daily life relates to higher subjective well-being. Findings showed that greater increases in positive affect were not related to higher subjective well-being, both when investigated in the laboratory and in daily life. Instead, people with higher levels of subjective well-being showed reduced affective reactions to positive events in daily life, pointing to the importance of a relative greater emotional stability. At the neural level, changes in positive affective experiences were mirrored by increased activations in emotion-related (e.g., ventral striatum) regions as well as deactivation in a fronto-parietal control network. These neural activations were not related to changes in positive affective experiences in daily life. The work in this dissertation indicates that not the experience of particularly intense positive affective states, but rather less fluctuation in momentary positive affective experiences seems to be essential to the overall composition of subjective well-being. The present dissertation further emphasizes the need to integrate different methods in the study of emotion. Concluding, this dissertation advances our understanding of the processes underlying subjective well-being.

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Books on the topic "Interindividual difference"

1

Burianova, Hana. Predictability of interindividual variation across a variety of tasks and further implications of quantitative interindividual differences in underlying neural processes. Ottawa: National Library of Canada, 2003.

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Dasgupta, Mary Ellen. INTRAINDIVIDUAL CHANGE AND INTERINDIVIDUAL DIFFERENCES IN COMPONENTS OF HEALTH-SEEKING BEHAVIOR AND HEALTH ORIENTATION OF OLDER ADULTS. 1993.

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Ramírez-Vélez, Robinson, and Mikel Izquierdo, eds. Precision Physical Activity and Exercise Prescriptions for Disease Prevention: The Effect of Interindividual Variability Under Different Training Approaches. Frontiers Media SA, 2019. http://dx.doi.org/10.3389/978-2-88963-063-9.

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Izquierdo, Mikel, and Robinson Ramírez-Vélez, eds. Precision Physical Activity and Exercise Prescriptions for Disease Prevention: The Effect of Interindividual Variability Under Different Training Approaches, Volume II. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-456-5.

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Ferraro, Kenneth F. Heterogeneity. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190665340.003.0005.

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Gerontologists are intrigued by the astonishing degree of heterogeneity in later life and seek to identify the mechanisms that create or reduce it. Oddly, some fields of recent inquiry emphasize diversity associated with race, sex, and class, while giving scant attention to diversity by age. Gerontologists, by contrast, are vigilant to explore diversity between and within age groups. This chapter delineates some of the sources of heterogeneity in later life, including interindividual and intercohort differences, intraindividual change, non-normative events, and stochastic processes. It also considers processes that may reduce heterogeneity. To illustrate the axiom of heterogeneity, it identifies age and cohort differences in the consequences of environmental exposures.

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Howard, Richard F. Acute pain in children. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199234721.003.0010.

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Age and maturity affect the perception and expression of pain in children. A variety of pain assessment tools are needed to cover different age groups. The British National Formulary for Children is a source of correct formulations and doses of analgesics for children of different ages. Neonates show very high interindividual response to analgesic drugs. Between 2yrs and 12yrs, the clearance of drugs exceeds that of adults and relatively higher doses may be needed. Patient-controlled, nurse-controlled, and neuraxial analgesia can all be used in infants and children. Reducing procedural pain in children is important and requires a combination of pharmacological and non-pharmacological methods.

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Laumbach, Robert, and Michael Gochfeld. Toxicology. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0007.

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This chapter describes the basic principles of toxicology and their application to occupational and environmental health. Topics covered include pathways that toxic substances may take from sources in the environment to molecular targets in the cells of the body where toxic effects occur. These pathways include routes of exposure, absorption into the body, distribution to organs and tissues, metabolism, storage, and excretion. The various types of toxicological endpoints are discussed, along with the concepts of dose-response relationships, threshold doses, and the basis of interindividual differences and interspecies differences in response to exposure to toxic substances. The diversity of cellular and molecular mechanisms of toxicity, including enzyme induction and inhibition, oxidative stress, mutagenesis, carcinogenesis, and teratogenesis, are discussed and the chapter concludes with examples of practical applications in clinical evaluation and in toxicity testing.

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Poelmans, Steven, and Elena O. Stepanova. A Neuroscience Perspective of the Work–Family–Life Interface. Edited by Tammy D. Allen and Lillian T. Eby. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199337538.013.31.

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This chapter offers a review of neuroscientific principles and findings that inform the understanding of the intraindividual and interindividual experience of work–life conflict and enrichment. Advances in neuroscientific research have generated a better understanding of different basic processes that underlie role conflict, such as expectations, attention, multitasking, and stress. In the tradition of positive psychology we have seen a significant shift in work–family research toward a positive approach, complementing a conflict perspective with a focus on facilitation, enrichment, and balance. In this chapter we highlight two resources that are key for understanding positive spillover effects: energy/dopaminergic levels and social support. Inspired by insights, theories, and methods in neuroscience, we formulate recommendations for future interdisciplinary research in the work–family research domain.

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Book chapters on the topic "Interindividual difference"

1

Hoffmann, Stefan, and Payam Akbar. "Interindividual Differences." In Consumer Behavior, 117–29. Wiesbaden: Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-39476-9_8.

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Nesselroade, John R. "Interindividual differences in intraindividual change." In Best methods for the analysis of change: Recent advances, unanswered questions, future directions., 92–105. Washington: American Psychological Association, 1991. http://dx.doi.org/10.1037/10099-006.

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McArdle, John J., and John R. Nesselroade. "Studying interindividual differences in intraindividual changes." In Longitudinal data analysis using structural equation models., 143–50. Washington: American Psychological Association, 2014. http://dx.doi.org/10.1037/14440-012.

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Wang, Lijuan, and Miao Yang. "On Interindividual Differences in Intraindividual Changes." In Longitudinal Multivariate Psychology, 166–88. New York, NY : Routledge, 2019. | Series: Multivariate applications series |: Routledge, 2018. http://dx.doi.org/10.4324/9781315160542-9.

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Reis, Maria Júlia Figueiró. "Normal Sleep: Interindividual Differences and Sleep Variability." In Sleep Medicine and Physical Therapy, 13–20. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85074-6_2.

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Van Cutsem, Jeroen, Emilie Dessy, Martine Van Puyvelde, Olivier Mairesse, Xavier Neyt, and Nathalie Pattyn. "Trait Interindividual Differences in the Effectiveness of Modafinil." In Advances in Safety Management and Human Performance, 12–20. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80288-2_2.

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Zänkert, Sandra, and Brigitte M. Kudielka. "Intra- and interindividual differences in cortisol stress responses." In Routledge International Handbook of Social Neuroendocrinology, 454–75. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2018. http://dx.doi.org/10.4324/9781315200439-27.

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Moog, R. "Interindividual Differences in Sleep Patterns During Night and Shift Work." In Sleep Related Disorders and Internal Diseases, 89–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72560-9_8.

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Thier, R. "Chemoprotection and Interindividual Differences in Response to Biological Reactive Intermediates." In Advances in Experimental Medicine and Biology, 587–94. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-0667-6_87.

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Trudewind, Clemens, and Klaus Schneider. "Interindividual Differences in the Development of Exploratory Behavior: Methodological Considerations." In Curiosity and Exploration, 151–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-77132-3_9.

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Conference papers on the topic "Interindividual difference"

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Scott, Paul. "Accounting for Interindividual Differences in Trajectories When Assessing Cross-Lag Relationships." In 2020 AERA Annual Meeting. Washington DC: AERA, 2020. http://dx.doi.org/10.3102/1570508.

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Sajti, E., G. Chanthavixay, and C. Glass. "Exploiting Natural Genetic Variation in Mice to Explore the Molecular Basis for Interindividual Differences in Oxygen-Induced Lung Injury." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4334.

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Stanciu, Ionutdorin. "AGE DIFFERENCES AND PREFERENCES IN ONLINE BEHAVIOR. HOW AGEING AND DIGITAL CONNECTEDNESS ARE REFLECTED IN CURRENT RESEARCH REGARDING THE USE OF SOCIAL MEDIA." In eLSE 2017. Carol I National Defence University Publishing House, 2017. http://dx.doi.org/10.12753/2066-026x-17-173.

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The people’s need for social connectedness was thoroughly documented and established in research literature. Currently, we experience rapidly increasing technological developments which not only allow for new ways of ‘digital’ connections, but, arguably so, require people to use digital channels of socializing. The use of Internet, in general, and social media, is not limited to searching for information but it includes also knowledge construction. However, not all of us react the same when faced with change in our lives, and even more so, with respect to the use of new technologies. Ageing is increasingly important because of the role of the elderlies in the modern society. Increasingly more elderly citizens live active and connected lives. The advances in medicine and the increase in welfare lead to an increase in life expectancy and to an unprecedented diversity in terms of age with respect to the use of social media. With a current 2.34 billion users of social media, and with a projected increase of 200 million new users in 2017, more than a few elderly users are expected to join social media. As such, the question arises, is there such a thing as a “generational gap/divide”, with respect to the use of social media, in general, and social networking, in particular? Current research provide some conflicting evidence, with most studies refraining from tacking age directly and resorting to considering age as a moderator of other pathways of influence between various predictors and outcomes of interest. We present a synthetic but thorough and updated review of the state of the art with respect to the past and current approaches to investigating the role of age in interindividual differences with respect to the adoption of social media, with a specific focus on social networking media.

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Hermán, F., P. Hadházy, and K. Magyar. "IN VIVO SELECTIVITY BETWEEN HYPOTENSIVE AND PLATELET ANTIAGGREGATING ACTIONS OF ILOPROST AND PGI2 IN BEAGLE DOGS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643456.

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Iloprost (Schering A.G.) is a chemically stable derivative of prostacyclin. We compared the hypotensive and antiaggregatory effects of PGI2 and Iloprost. The concentration producing 50% inhibition (IC50) of ADP-induced platelet aggregation in vitro was 0.35±0.15 nmol/1 for PGI2 and 0.56±0.2 nmol/1 for Iloprost (n=5). The in vivo antiaggregatory activity was measured with a modified filtration pressure technique (F.Hermán et al.Thromb. Res.44 /1986/, 575) in anaesthetized beagle dogs; the change in arterial blood pressure was recorded simultaneously. Using this technique, the dose-response relationship and the duration of action of prostacyclin and Iloprost following bolus administration have been determined. PGI2 was equipotent with Iloprost in inhibiting platelet aggregation in vivo (ED25: 0.25±0.04 nmol/kg; 0.28±0.05 respectively). At the same time PGI2 was two times as potent as Iloprost in decreasing the mean arterial blood pressure (ED25: 0.41±0.12 nmol/kg; 0.87±0.14 nmol/kg respectively). The antiaggregatory and hypotensive effects of Iloprost last longer in each experiment than that of PGI2, but did not reach the level of significance probably due to the considerable interindividual differences. The in vivo selectivity ratios (hypotensive potency/antiaggregatory potency) of Iloprost and PGI2 were 0.32 and 0.6 respectively. These results show that in anesthetized beagles Iloprost is somewhat more selective than PGI2 in inhibiting platelet aggregation.

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Heptner, W., J. R. Suárez, and V. Lütgendorf. "STUDIES ON PLATELET AGGREGATION BY IMPEDANCE AGGREGOMETRY AND ATP SECRETION IN NON-ANTICOAGULANT BLOOD." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644810.

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Investigations in vitro on the time-dependent increase in thrombin activityand platelet function have been used tocharacterize the kinetics of the clotting process in nonanticoagulated blood. The test procedures described involve great effort and expense and therefore are not suitable for routine tests in pharmacology and clinical pharmacology. The present contribution describes the determination of clotting times in ATP secretion in the Chrono-Log Whole Blood Aggregometer.Blood was taken from healthy donors who had not used any drug in the two weeks before the trial. 0.5 ml blood wereimmediately transfered into siliconizedglass cuvettes containing 0.4 ml salineand 0.1 ml luciferin-luciferase cocktail prewarmed to 37°C. Impedance and luminescence were recorded continuously. Clotting at the electrodes is indicated by an immediate steep rise in both impedance and luminescence. Clotting time is defined as the time from diluting the blood in the cuvettes until the point at which marked elevation of these variables begins.In the blood of twelve subjects the mean clotting time was 3.8 min and intersubject variation (SD) was 0.45 min. Drastic interindividual differences in response to collagen and ADP in citratedwhole blood were observed in the study group.In vitro addition of 20 μl Fibraccel(Behringwerke AG, Marburg, FRG),a platelet factor 3 containing plateletextract decreased clotting time by 35 %(n=10). In the presence of 0.2 U heparin a slow and lona-lasting increase in impedance was seen. 1 g oral AspirinR didnot influence clotting time measured ex vivo.The results indicate that whole blood aggregometry is a simple, fast, and precise method of determining blood clotting and the effects of drugs in a medium reflecting almost physiological conditions.

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Devilée, P. P., H. F. B. M. Fiolet, M. C. E. van Dam-Mieras, and H. C. HemKer. "THE EFFECT OF LOW DOSE HEPARIN ON THE FEEDBACK ACTIVATION OF FACTOR VIII IN VIVO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643617.

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Heparin is a well established drug in the treatment and prophylaxis of thrombosis. However, the in vitro methods for thecontrol of heparin therapy (aPTT, anti-Xa, anti-II) often are not sufficiently sensitive to monitor low-dose heparin therapy. We used an assay that is based upon the in vivo activation of factor VIII at the site of skin punction: the factor VIII activity in blood samples taken from a capillary wound increases with time Hurlet-Birk Jenssen et al. Path. Biol. 24, 6 (1976).Assay: 50 μl blood samples are taken 30, 60 and 90 sec after capillary puncture. The samples are diluted with 950μl, 10 mM sodium citrate, Mich, buffer and centrifugated(3 min, 4 °C). In the diluted samples the factor VIII activity is determined.In healthy volunteers the increase in factor VIII activity in the successive samples is fairly constant (1.4 - 1.8 fold) in spite of distinct interindividual differences in the factor VIII level. In patients receiving continuous intravenous heparin (20000 IE/24 h) and in a hemophiliaA patient there was no increase in factor VIII activity with the time. In individuals receiving 5000 IE heparin subcutaneously the increase in factor VIII activity was dependent upon the time interval between heparin injection and sampling. There was almost no influence of heparin on the 30 s samples but the 90 and 150 sec. samples showed distinctly prolonged clotting times at sampling points from 2 to 4 hours after heparin administration. It was not possible to detect the heparin effectby an automated anti-IIa assay or in a prothrombin time assay because the heparinlevels were below the detection limit of the tests.These results suggest that low-dose heparin therapy has a definite influence on the feedback activation of factor VIII even in concentrations that are not detectable with the usual heparin tests.

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Kries, R. V., M. J. Shearer, P. T. McCarthy, M. Haug, and C. Harzer. "VITAMIN K1 IN HUMAN MILK." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643400.

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Fatal vitamin K deficiency haemorrhage has been observed in breast fed babies. Though the incidence of vitamin K deficiency haemorrhage seems to be low in exclusively breastfed babies in Germany, subclinical vitamin K deficiency is by far more common as demonstrated in recent studies. Vitamin K concentrations in human milk are lower than in cow's milk and infant formula, however, nothing is known about the factors determinating the vitamin K1 concentrations in human milk. Vitamin K1 concentrations in human milk were studied during the first five weeks of lactation with respect to a) stage of lactation, b) interindividual differences, c) relationship of vitamin K1 to other lipids, and d) influence of oral supplements of vitamin K1 given to the mother. Milk samples from 9 mothers were collected on day 1,3,5,22,29 and 36 of lactation using standarized techniques.a) Vitamin K1 concentrations in colostral milk, day 1-5 (median 1,8 ng/ml) were significanctly higher than in mature milk, day 22-36 (median 1,1 ng/ml) (Wilcoxon U-Test p< 0,01). These changes during the course of lactation must be considered for estimation of the vitamin K supply in breastfed babies.b) Vitamin K concentrations both for colostral and mature milk were found to vary widely: colostral milk 0,6-4,4 ng/ml, mature milk 0,4 - 2,8 ng/ml.c) For colostral milk regression analyses revealed good correlations of vitamin K1 to cholesterol but none to total lipid and phospholipids, whereas no correlation to either lipid was observed for mature milk. Cholesterol appears to have a role in vitamin K1 secretion into colostral milk.d) Vitamin K1 concentrations of maternal milk were influenced by oral supplements given to the mother. Even with a dose of 100 μ vitamin K1 (similar to the dose which may be ingested with a meal) a twofold increase of the vitamin K1. content of breast milk was observed. These data suggest that mutritional factors may influence the vitamin concentration in human milk. Vitamin K supplements for breastfeeding mothers on vitamin K1 poor diets could improve the vitamin K supply of these babies.

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Reports on the topic "Interindividual difference"

1

Goth-Goldstein, Regine. Interindividual Differences in Metabolism of Carcinogens as a Risk Factor for Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2002. http://dx.doi.org/10.21236/ada404747.

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