Relevant bibliographies by topics / INTERFERON SIGNATURE

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'INTERFERON SIGNATURE'

Author: Grafiati
Published: 1 April 2023
Last updated: 26 July 2025

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Journal articles on the topic "INTERFERON SIGNATURE"

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Suspitsin, E. N., R. K. Raupov, E. M. Kuchinskaya, and M. M. Kostik. "Analysis of interferon type I signature for differential diagnosis of diseases of the immune system ( review of literature)." Russian Clinical Laboratory Diagnostics 66, no. 5 (2021): 279–84. http://dx.doi.org/10.51620/0869-2084-2021-66-5-279-284.

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Type 1 interferons (IFN1) are both key molecules of antiviral defense and potent inflammatory mediators. In 2003, increased expression of a variety of interferon 1-regulated genes was observed in a blood cells of patients with systemic lupus erythematosus (SLE). This phenomenon was called the type 1 interferon signature (IFN1-signature). Since then, expression patterns indicating the presence of an IFN1-signature were consistently detected in a range of monogenic and complex autoimmune and autoinflammatory conditions. A quantitative indicator reflecting the degree of hyperactivation of the IFN
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Visan, Ioana. "The interferon signature." Nature Immunology 18, no. 2 (2017): 151. http://dx.doi.org/10.1038/ni.3670.

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Smith, Michael Alexander, Chia-Chien Chiang, Dominic Sinibaldi, et al. "Using the Circulating Proteome to Assess Type I Interferon Activity in Systemic Lupus Erythematosus." Journal of Immunology 198, no. 1_Supplement (2017): 210.1. http://dx.doi.org/10.4049/jimmunol.198.supp.210.1.

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Abstract Type I interferon (IFN) signaling drives pathology in systemic lupus erythematosus (SLE) and can be tracked via IFN-inducible transcripts present in whole blood as described by several IFN gene signatures. As SLE is a complex disease affecting diverse organ systems, we examined whether measurement of circulating proteins, which can infiltrate the bloodstream from afflicted tissues, might also offer insight into global IFN activity. The presence of anti-DNA autoantibodies in patient serum has prevented effective use of SOMAmers for the evaluation of circulating proteins in SLE. Here, w
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Carrero, Javier, Boris Calderon, Stephen Ferris, and Emil Unanue. "Evaluation of the role of type I interferon to the development of type 1 diabetes. (BA3P.131)." Journal of Immunology 192, no. 1_Supplement (2014): 44.1. http://dx.doi.org/10.4049/jimmunol.192.supp.44.1.

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Abstract Our goal is to identify the earliest immunologically relevant events that trigger autoimmune diabetes. The first detectable inflammatory signature in the NOD mouse is the upregulation of type I interferons and an interferon-inducible gene signature. We reason that understanding the early interferon signature may provide targets for the prevention, treatment, or diagnosis of autoimmune diabetes. The two ubiquitous interferon receptors (IFNAR and IFNGR) upregulate hundreds genes, some shared and some unique to each receptor. We backcrossed the type I interferon receptor onto NOD backgro
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Rigolet, Muriel, Cyrielle Hou, Yasmine Baba Amer, et al. "Distinct interferon signatures stratify inflammatory and dysimmune myopathies." RMD Open 5, no. 1 (2019): e000811. http://dx.doi.org/10.1136/rmdopen-2018-000811.

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ObjectiveThe role of interferons (IFN) in the pathophysiology of primary inflammatory and dysimmune myopathies (IDM) is increasingly investigated, notably because specific neutralisation approaches may constitute promising therapeutic tracks. In present work we analysed the muscular expression of specific IFNα/β and IFNγ-stimulated genes in patients with various types of IDM.Methods39 patients with IDM with inclusion body myositis (IBM, n=9), dermatomyositis (DM, n=10), necrotising autoimmune myopathies (NAM, n=10) and antisynthetase myositis (ASM, n=10), and 10 controls were included. Quantif
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Ramana, Chilakamarti V. "Regulation of a Metabolic Gene Signature in Response to Respiratory Viruses and Type I Interferon Signaling." Journal of Molecular Pathology 5, no. 1 (2024): 133–52. http://dx.doi.org/10.3390/jmp5010009.

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Respiratory viruses are the causative agents responsible for seasonal epidemics and occasional pandemic outbreaks and are a leading cause of death worldwide. Type I interferon (IFNα/β) signaling in the lung epithelial cells plays a major role in the innate immunity to respiratory viruses. Gene signatures are a set of differentially expressed genes in a particular disease or condition and are used to diagnose, monitor, and predict disease progression. These signatures can be used to identify regulatory modules and gene regulatory networks (GRNs) in mammalian signal transduction pathways. Consid
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An, Yuanyuan, and Hua Duan. "The Comprehensive Analysis of Interferon-Related Prognostic Signature with regard to Immune Features in Ovarian Cancer." Disease Markers 2022 (June 20, 2022): 1–24. http://dx.doi.org/10.1155/2022/7900785.

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Interferon plays an important role in immune response of ovarian cancer. However, the expression pattern of interferon in ovarian cancer remains unclear. This study is aimed at exploring the expression profile of interferon-relate genes and constructing an interferon-based prognostic signature in ovarian cancer. The ovarian cancer samples collected from TCGA database were viewed as the training set, and ovarian cancer samples collected from GEO datasets were used as the independent validation sets. Univariate Cox regression analysis and multivariate Cox regression analysis were used to constru
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Vavougios, George D., Theodoros Mavridis, Triantafyllos Doskas, Olga Papaggeli, Pelagia Foka, and Georgios Hadjigeorgiou. "SARS-CoV-2-Induced Type I Interferon Signaling Dysregulation in Olfactory Networks Implications for Alzheimer’s Disease." Current Issues in Molecular Biology 46, no. 5 (2024): 4565–79. http://dx.doi.org/10.3390/cimb46050277.

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Type I interferon signaling (IFN-I) perturbations are major drivers of COVID-19. Dysregulated IFN-I in the brain, however, has been linked to both reduced cognitive resilience and neurodegenerative diseases such as Alzheimer’s. Previous works from our group have proposed a model where peripheral induction of IFN-I may be relayed to the CNS, even in the absence of fulminant infection. The aim of our study was to identify significantly enriched IFN-I signatures and genes along the transolfactory route, utilizing published datasets of the nasal mucosa and olfactory bulb amygdala transcriptomes of
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Gallay, Laure, Guy Mouchiroud, and Bénédicte Chazaud. "Interferon-signature in idiopathic inflammatory myopathies." Current Opinion in Rheumatology 31, no. 6 (2019): 634–42. http://dx.doi.org/10.1097/bor.0000000000000653.

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Rönnblom, Lars, and Maija-Leena Eloranta. "The interferon signature in autoimmune diseases." Current Opinion in Rheumatology 25, no. 2 (2013): 248–53. http://dx.doi.org/10.1097/bor.0b013e32835c7e32.

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Dissertations / Theses on the topic "INTERFERON SIGNATURE"

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Lincez, Pamela Joan. "MDA5 and a type 1 interferon signature in the development of type 1 diabetes." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52850.

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Type 1 diabetes (T1D) is a debilitating disease involving the autoimmune destruction of insulin-producing pancreatic β-cells. The personal and economic burden of this disease is enormous, therefore simpler and more cost effective therapeutic approaches than those currently available must be explored. In children at risk for T1D, a unique type 1 interferon (IFN-I) transcriptional signature precedes islet autoimmunity. Recent onset of T1D strongly associates with infection by RNA viruses like coxsackievirus that induce IFN-I. Importantly, genetic variants in the T1D risk locus IFIH1 are linked
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Lisney, Anna [Verfasser]. "Analysis of SIGLEC1 as a surrogate marker for a type I interferon signature in autoimmune congenital heart block and primary Sjögren’s syndrome / Anna Lisney." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/120204381X/34.

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TESSER, ALESSANDRA. "PROFILO FUNZIONALE DI PAZIENTI CON LUPUS ERITEMATOSO SISTEMICO E CORRELAZIONE CON I MECCANISMI COINVOLTI IN DIVERSE FORME MONOGENICHE DELLA MALATTIA." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2922621.

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Il lupus eritematoso sistemico (LES) rappresenta una complessa patologia multisistemica, all’interno del cui universo si possono spesso individuare eventi patogenetici diversi ma riconducibili a quadri clinici sovrapponibili. Una possibile caratteristica comune può considerarsi l’utilizzo improprio della risposta immunitaria agli acidi nucleici. Per comprendere il ruolo di questo tipo di risposta, ci siamo concentrati sullo studio delle Interferonopatie di tipo I, un gruppo di malattie monogeniche di recente definizione, causate da alterazioni nel meccanismo di riconoscimento e metabolismo deg
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Domaszewska, Teresa. "Unraveling transcript-based variability of host responses to Tuberculosis." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19829.

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Jedes Jahr treten weltweit über zehn Millionen Fälle von Tuberkulose (TB) auf. Die Weltgesundheitsorganisation (WHO) schätzt, dass ein Drittel der Weltbevölkerung mit dem Erreger Mycobacterium tuberculosis (Mtb) infiziert ist. Bei fünf bis zehn Prozent aller latent Infizierten bricht Tuberkulose im Laufe des Lebens aus. Dennoch sind bereits 100 Jahre seit der Entdeckung von Mtb vergangen, ohne dass die entscheidenden Faktoren für den unterschiedlichen Infektionsverlauf bekannt wären. In dieser Arbeit untersuche ich die unterschiedlichen Reaktionen auf eine Tuberkuloseinfektion in verschiedenen
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Bettacchioli, Eléonore. "Identification de signatures biologiques pour la stratification des patients atteints de maladies auto-immunes systémiques." Electronic Thesis or Diss., Brest, 2025. http://www.theses.fr/2025BRES0013.

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Les maladies auto-immunes telles que la maladie de Sjögren (SjD) et le lupus érythémateux systémique (LES) posent des défis majeurs liés à une grande hétérogénéité clinique et biologique. Au travers d’analyses multi-omiques, cette thèse présente des objectifs multiples : (i) Caractériser le profil clinique et biologique des patients atteints de SjD selon leur profil d’auto-anticorps, (ii) Créer un outil en ligne facilitant l'accès et l'interprétation des données de transcriptomique du LES, et (iii) Analyser les interactions cellulaires dans le tissu rénal du LES. Dans la SjD, la stratification
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Strauß, Romy [Verfasser]. "Der Einfluss von Typ-I-Interferonen auf Leukozyten-Subpopulationen im Blut : ein neuer diagnostischer Ansatz für die Verwendung der Interferon-Signatur als Biomarker beim systemischen Lupus erythematodes / Romy Strauß." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1176632272/34.

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Imgenberg-Kreuz, Juliana. "Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310388.

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Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. Although the precise mechanisms leading to autoimmune processes are not well defined, recent studies suggest that aberrant DNA methylation and gene expression patterns may play a central role in the pathogenesis of these disorders. The aim of this
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Outlioua, Ahmed. "Exploration des cytokines pro-inflammatoires et de l’inflammasome NLRP3 dans les infections intracellulaires : cas de H. pylori et des virus à ARN Gastric IL-1β, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling The Role of Optineurin in Antiviral Type I Interferon Production Possible introduction of Leishmania tropica to urban areas determined by epidemiological and clinical profiles of patients with cutaneous leishmaniasis in Casablanca (Morocco)". Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL029.

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Helicobacter pylori (H. pylori) est une bactérie qui infecte l’estomac et induit une gastrite inflammatoire, qui peut être chronique et évoluer vers un cancer gastrique. La sévérité de l’infection et son évolution clinique sont associées aux différents facteurs notamment le statut immunitaire de l’hôte. La réponse inflammatoire initiale à l'infection à H. pylori entraîne la sécrétion d'un large panel de cytokines, notamment l'interleukine-1β (IL-1β), l'IL-8 et l'IL-17A. qui semblent jouer un rôle clé dans l'initiation et la progression du cancer gastrique. Parmi ces cytokines, l'IL-1β est une
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Books on the topic "INTERFERON SIGNATURE"

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Buckalew, Nelly A. Pain and Addiction in Older Adults (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190265366.003.0031.

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Addressing unique effects of both addiction and analgesia on older adults, this chapter defines the geriatric population and proceeds to discuss the recognition of addiction or substance misuse in it. There is little argument that the elderly have special diagnostic concerns and management needs that are imposed upon those of younger adults. The concept of the pain signature is introduced as a measure of the functions with which the individual’s pain interferes. Four instruments serving as diagnostic aids are included in tabular format: the pain signature elements; a list of recommended patien
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Book chapters on the topic "INTERFERON SIGNATURE"

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Osafo, Newman, and Silvio Owusu Dei. "Interferon Signature Analysis." In Reference Module in Biomedical Sciences. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-818731-9.00073-2.

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Aiman, Ayesha, Seemi Farhat Basir, and Asimul Islam. "Interferons Horizon Therapeutics." In Interferon - Immune Metabolism [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104718.

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Interferons (IFNs) are a family of multi-functional proteins, called cytokines, that are produced by immune cells such as leukocytes, natural killer (NK) cells, macrophages, fibroblasts, and epithelial cells. The minute amount of these α-helical glycoproteins, produced by mammalian cells, are firm components of the innate arm of the immune system providing rapid and broad protection against numerous types of invading pathogens. Interferons, from their discovery in the 19th century, have always held out a promise of important clinical utility first as an antiviral agent and more recently holdin
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Peter, Matuku-Kisaumbi. "The Role of TB Biomarkers in Diagnosis, Prognosis and Prevention of Tuberculosis." In Infectious Diseases. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.115129.

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This chapter focuses on how biomarkers of tuberculosis can be utilized in the diagnosis, prognosis and treatment monitoring of TB. Tuberculosis biomarkers are measurable molecular indicators present and/or whose levels are altered in disease states. Found in blood, urine, bronchoalveolar lavage or sputum, biomarkers can originate from the bacteria (e.g. Ag85, lipoarabinomannan (LAM) and bacterial DNA) or from the host (e.g. cytokines/chemokines, metabolites, transcriptomics, mixed signatures and other proteins). Despite the lack of tuberculous specificity, Ag85 can facilitate early detection o
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Chen Hsian-Min, Chai Jyh-Wen, Chen Clayton Chi-Chang, et al. "Detection and Classification of MS Lesions in Multispectral MR Images." In Frontiers in Artificial Intelligence and Applications. IOS Press, 2015. https://doi.org/10.3233/978-1-61499-484-8-2044.

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Quantitative analysis of patients with multiple sclerosis (MS) is an important issue in both diagnosis and therapy monitoring. We propose a new spectral signature detection approach for quantitative volumetric analysis of multispectral MRI. It is called constrained energy minimization (CEM) method, which is derived from the hyperspectral imaging processing. The CEM makes use of a finite impulse response (FIR) filter to linearly constrain a desired object while minimizing interfering effects caused by other unknown signal sources. The results show that the CEM method is a promising and effectiv
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Bentarki, Houda, Abdelkader Makhoute, and Tőkési Karoly. "Signatures of the Mode Symmetries in Sapphire PhoXonic Cavities." In Advances in Systems Analysis, Software Engineering, and High Performance Computing. IGI Global, 2023. http://dx.doi.org/10.4018/979-8-3693-0497-6.ch007.

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The acousto-optic couplings mechanisms are investigated theoretically in photonic and phononic crystals with simultaneous band gaps. The authors have focused on the acousto-optic couplings inside a phoXonic cavity by taking into account two coupling mechanisms, the photo elastic effect and effect of movement of the interfaces. They discuss the symmetry of modes to distinguish those that don't interfere in an efficient way. They calculate the modulation of the frequency of the photonic mode during a period of acoustic oscillations with a finite element method (FE) (COMSOL®Multiphysics). The two
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Conference papers on the topic "INTERFERON SIGNATURE"

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Zhang, Yimin D., Yanwu Ding, Khanh Pham, Dan Shen, and Genshe Chen. "Single-Satellite Location of Ground Electromagnetic Interferer Exploiting Doppler Signatures." In 2024 58th Asilomar Conference on Signals, Systems, and Computers. IEEE, 2024. https://doi.org/10.1109/ieeeconf60004.2024.10942807.

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Picard, Donald, Olivier Bellavance, Gabriel Cyr, and Andréanne Potvin. "Next Step to Advanced Data Analysis with Pulsed Eddy Currents." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-17568.

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Abstract Pulsed Eddy Current (PEC) is a proven inspection method used for the detection and assessment of Corrosion Under Insulation (CUI), Corrosion Under Fireproofing (CUF), and material loss under various types of coatings or materials that prevent direct access to the surface. In recent years, PEC inspections have become increasingly common, enabled by more sensitive sensors and innovations that increased productivity such as dynamic scanning and Pulsed Eddy Current Array (PECA) sensors. The technology remains cross sensitive to wall loss and changes in electromagnetic properties or the pr
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Allanore, Y., A. Cauvet, M. Schwarz, and J. Avouac. "AB1163 TYPE 1 INTERFERON SIGNATURE IN SYSTEMIC SCLEROSIS." In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.2775.

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Han, Shuhong, Haoyang Zhuang, Pui Lee, Mingjia Li, Peter Nigrovic, and Westley H. Reeves. "186 NRF2 regulation of the interferon signature in lupus macrophages." In 13th International Congress on Systemic Lupus Erythematosus (LUPUS 2019), San Francisco, California, USA, April 5–8, 2019, Abstract Presentations. Lupus Foundation of America, 2019. http://dx.doi.org/10.1136/lupus-2019-lsm.186.

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Mendoza, FA, S. Piera-Velazquez, P. Wermuth, S. Addya, C. Feghali-Bostwick, and SA Jimenez. "OP0096 Interferon signature in systemic sclerosis lung microvascular endothelial cells." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3739.

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Rönnblom, L. "SP0174 The value of type i interferon signature to stratify patients." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.7782.

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Geiss, C., M. Houtman, R. Micheroli, et al. "OP0192 SYNOVITIS IN SYSTEMIC SCLEROSIS IS CHARACTERISED BY AN INTERFERON SIGNATURE." In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.342.

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Yun, J. H., S. Lee, R. Chase, et al. "Interferon-Inducible Blood Gene Expression Signature in COPD Patients with CT Airway Disease Phenotypes." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4052.

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Tesser, Alessandra, Gian Marco Moneta, Antonella Insalaco, et al. "AB1062 INTER-LABORATORY COMPARISON OF TYPE I INTERFERON SIGNATURE ANALYSES: PAVING THE WAY TO SHARE RECOMMENDATIONS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.7041.

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Yun, J. H., S. Lee, R. Chase, et al. "An Interferon Inducible Signature of Airway Disease from Gene Expression Profiling of Peripheral Blood from COPDGene." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4467.

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Reports on the topic "INTERFERON SIGNATURE"

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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture indu
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Ficht, Thomas, Gary Splitter, Menachem Banai, and Menachem Davidson. Characterization of B. Melinensis REV 1 Attenuated Mutants. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580667.bard.

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Brucella Mutagenesis (TAMU) The working hypothesis for this study was that survival of Brucella vaccines was directly related to their persistence in the host. This premise is based on previously published work detailing the survival of the currently employed vaccine strains S19 and Rev 1. The approach employed signature-tagged mutagenesis to construct mutants interrupted in individual genes, and the mouse model to identify mutants with attenuated virulence/survival. Intracellular survival in macrophages is the key to both reproductive disease in ruminants and reticuloendothelial disease obser
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