Academic literature on the topic 'Interactions cellules-Surface'
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Journal articles on the topic "Interactions cellules-Surface":
Perron, H. "La voie des rétrovirus humain endogènes, un espoir thérapeutique dans la schizophrénie." European Psychiatry 30, S2 (November 2015): S25. http://dx.doi.org/10.1016/j.eurpsy.2015.09.077.
Dissertations / Theses on the topic "Interactions cellules-Surface":
Lipsker, Dan Michael. "Interactions de la protéine de stress hsp70 avec les cellules dendritiques humaines : Etude du trafic de certains antigènes de surface des cellules de Langerhans humaines." Université Louis Pasteur (Strasbourg) (1971-2008), 2002. http://www.theses.fr/2002STR13044.
Kirichuk, Oksana. "Avancées dans les études in vitro des interactions cellule-glycocalyx : développement d'une plateforme définie mécaniquement et biochimiquement." Electronic Thesis or Diss., Université Grenoble Alpes, 2023. http://www.theses.fr/2023GRALY084.
Cell adhesion to the blood vessel wall is a complex, highly regulated physiological process. Red blood cells must repel from the blood vessel wall to prevent blood clotting while immune cells can be recruited from the vascular system to migrate into surrounding tissues. Cell adhesion hinges on the critical role played by the glycocalyx, a soft gel-like layer coating the vascular wall. However, how glycocalyx mechanical (softness, thickness) and biochemical (the composition and the density of surface receptors) properties affect this regulation is still poorly understood. Our hypothesis is that selective cell adhesion requires an intricate interplay of mechanical and biochemical cues. Elucidating the physical and molecular mechanisms that underpin selective adhesion directly in real blood vessels is challenging owing to the complexity and lack of control in in vivo systems. In my research, I aimed to construct an in vitro molecular interaction platform to facilitate mechanistic analyses. The platform combines a molecularly-defined model of the glycocalyx with mimetics of white blood cells under flow. While developing such a platform posed challenges, it offers the advantage of precise control over the physical and biochemical parameters of both the glycocalyx mimetic and cell mimetics.The newly developed glycocalyx model includes several key ingredients with tightly controlled properties: a brush of hyaluronan (HA, an essential component of the endothelial glycocalyx) is combined with P-selectin (an adhesion molecule on the endothelial cell surface critical for the homing of leukocytes). Building on previous experience in my research group, I employed a silica-supported lipid bilayer (SLB) bearing a monolayer of streptavidin (SAv), that can bind biotinylated molecules via biotin-SAv bonds. I introduce here a control of the in-plane mobility of molecules anchored to the fluid lipid bilayer using glutaraldehyde (GTA) as a cross-linking agent for SAv. Controlled grafting densities of one-end biotinylated HA chains of various lengths then create brushes of different mechanical properties. I also present a new methodology for quantitatively tuning the grafting density of smaller biotinylated molecules, which is deployed here to control the grafting density of an ‘adapter protein’ for anchoring P-selectin. The new in vitro model of the glycocalyx thus affords control over the lateral mobility, the surface density and the orientation of two distinct functional molecules.The second key component of the newly developed platform consists of white blood cell mimetics, developed based on commercially available microbeads with the size of a cell and a SAv coating. I introduce a methodology for simultaneous grafting of two types of proteins onto the bead surface: biotinylated CD44 (a ligand expressed on leukocyte surfaces, interacting specifically with HA) and PSGL-1 (a ligand of P-selectin). Additionally, I present a method for controlling the surface density of each of these proteins.I use a combination of methods as monitoring and quality control tools of glycocalyx model formation and bead functionalization: quartz crystal microbalance with dissipation monitoring (QCM-D); spectroscopic ellipsometry (SE), reflection interference contrast microscopy (RICM); confocal microscopy with fluorescence recovery after photobleaching (FRAP) capabilities, and flow cytometry.This newly established platform provides a controlled environment for studying blood cell adhesion, effectively bridging the divide between cell-glycocalyx chemical interactions and the mechanical aspects of cell migration under flow, including attachment and repulsion from the vascular wall. This platform holds the potential for expansion to encompass other surface adhesion molecules or to integrate multiple adhesion molecules, to gradually advance from the bottom up our understanding of the mechanisms governing cell adhesion to blood vessels
Sandrin, Ludivine. "Caractérisation des interactions biomoléculaires entre des ligands peptidiques immobilisés sur une surface et des récepteurs cellulaires." Phd thesis, Grenoble 1, 2009. http://tel.archives-ouvertes.fr/tel-00453636.
Khokhlova, Mariya. "Interactions of cells with oxide thin films." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC241.
In the present work we demonstrate how oxide thin films can be used as bioactive surfaces, a field of research which is still underexplored. For this purpose, thin films of TiO2, Al2O3, VOx and some others were deposited on glass substrates using the Pulsed Laser Deposition (PLD) technique, and adhesion, proliferation and differentiation of human bone marrow-derived mesenchymal stem cells were evaluated. Cell behavior was analyzed with respect to the various key surface parameters such as chemistry, wettability, morphology and the thickness of films.Our results indicate that thin films of TiO2 and Al2O3 can not only support mesenchymal stem cells adhesion and growth, but also can be used to influence osteogenic and chondrogenic differentiation path. Additionally, effect of oxide thin films on adhesion and growth of cancer cell lines was studied. We showed that culturing these cell lines on thin films affects their growth and, therefore, could be a valuable method to perform screening tests with drugs.This work will provide a better understanding of correlation between surface chemistry and cellular response, which has a high significance in the field of biomaterials fabrication
Hammache, Djilali. "Récepteurs glycolipidiques du VIH-1 à la surface des cellules CD4- (cellules épithéliales intestinales et spermatozoi͏̈des) et CD4+ (lymphocytes et macrophages) : analyse moléculaire des interactions virus-récepteurs au niveau des microdomaines de glycolipides reconstitués in vitro." Aix-Marseille 3, 1999. http://www.theses.fr/1999AIX30023.
Bernier, Marie-Charlotte. "Étude des interactions de nanoparticules de dioxyde de titane manufacturées avec des cellules et des biomolécules." Compiègne, 2011. http://www.theses.fr/2011COMP1973.
The small size (<100 nm) of titanium dioxide nanoparticles (nTiO2) gives them special properties that make them usefull for many everyday life applications (cosmetics, biomaterials. . . ). However, their effects on human health and the environment remain unkown or misunderstood. In this study, anatase nTiO2 and silica-coated rutile nTiO2 were tested on two murine cell lines: MC-3T3 pre-osteoblasts and L929 fibroblasts. In order to understand the cytotoxic mechanisms, TiO2 nanoparticles aggregation in different culture media and their interaction with fibronectin (Fn) –the major protein of the extracellular matrix– were studied. The consequences on MC-3T3 cell adhesion to Fn coatings were also evaluated. We have demonstrated that nTiO2 cytotoxicity depends on their concentration, the cell type, and the chemical nature of the nanoparticle surface. The interaction of nTiO2 with Fn and the decrease of cell adhesion also depend on the concentrations and surface’s nature of nanoparticles. Moreover, our cytoxicity studies concerning pre-osteoblasts have shown a secretion of high levels of the pro-inflammatory cytokine IL-6, known to mediate osteolysis by osteoclast activation. Thus, our study highlights the urgent need to reconsider the use of nanostructured biomaterials and to determine if they could inhibit bone reconstruction
Dallanegra, Anne. "Étude de l'activation lymphocytaire dans l'environnement épidermique : régulation de l'expression de surface du complexe CD3/TCR et implications biologiques : rôle des cytokines dans les interactions entre les lymphocytes et les cellules épidermiques." Lyon 1, 1992. http://www.theses.fr/1992LYO1T182.
Biagi, Sofia. "A mesoscale investigation of the endothelial glycocalyx and its interaction with blood flow." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAY083/document.
Polymer brushes are dense matrices of grafted macromolecules. In addition to brushes finely designed in laboratory, various examples are offered by Nature, as the endothelial glycocalyx, decorating the lumen of mammalian blood vessels. The interaction of such network with the flowing plasma and cells is still partially unknown.The present thesis, by mean of Dissipative Particle Dynamics simulations, proposes a coarse-grained model for the self-consistent analysis of a dense polymer brush under parabolic flow. Our mesoscale investigation highlights the relevance of collective effects, driven by hydrodynamics, and proposes novel interpretations regarding the rich phenomenology of the brush-flow system.Preliminary results are also provided for the interplay between a mesoscopic deformable flowing object (prototype of a red blood cell) and the grafted polymers
Forni, Luciana. "Recepteurs membrananires des lymphocytes b : interactions entre recepteurs et physiologie des cellules b." Paris 6, 1987. http://www.theses.fr/1987PA066375.
Castellana, Donatello. "Tumor-derived microvesicles in cancer progression : In vitro study in a prostate cancer model." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13034.
The plasma membrane plays a pivotal role in a large number of physiological processes. After cellular stimulation, externalization of PS in the exoplasmic leaflet of plasma membrane is followed by the shedding of membrane microvesicles (MV) in almost all cell types. MV composition reflect the antigenic profile of cells which they originate from, depending on the stimulus apply. Tumour microenvironment is highly enriched in MV shed from cells infiltrating the tumour tissue. Fibroblasts are associated with tumour cells at all stages of cancer progression. Focusing on fibroblasts implication in cancer, we propose an in vitro model in which cancer and normal cells communicate each other via MV. The aim of this study is to elucidate a mechanism, in which prostate cancer cells influence the behaviour of normal stromal cells that in turn affect the aggressiveness of carcinoma cells by mutual MV shedding, promoting or support the creation of a niche favourable for tumour development
Books on the topic "Interactions cellules-Surface":
1945-, Fukuda Minoru, ed. Cell surface carbohydrates and cell development. Boca Raton: CRC Press, 1992.
Membranology and subcellular organelles. Greenwich, Conn: JAI Press, 1992.