Academic literature on the topic 'Interacteur'
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Journal articles on the topic "Interacteur":
1
Rowe, Robert, Mark Coniglio, and Morton Subotnick. "Interactor 4.0.8." Leonardo Music Journal 2, no. 1 (1992): 122. http://dx.doi.org/10.2307/1513229.
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Godenzzi, Juan Carlos. "Significar e interactuar." Allpanchis 25, no. 42 (September 25, 2020): 53–79. http://dx.doi.org/10.36901/allpanchis.v25i42.770.
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Andonova, Veneta, Antonio Ladrón de Guevara, and Eric Brousseau. "Internet interacted: 1991‐2003." Management Research: Journal of the Iberoamerican Academy of Management 9, no. 3 (November 15, 2011): 192–206. http://dx.doi.org/10.1108/1536-541111181903.
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Diwnale, Tanvi, Shreyas Done, Pornima Dokhale, Disha Borale, Yash Divate, and Shardul Dixit. "GestureFlow: Intutive Multimedia Interactor." International Journal of Membrane Science and Technology 10, no. 2 (August 18, 2023): 4288–95. http://dx.doi.org/10.15379/ijmst.v10i2.3406.
Abstract:
Gesture Flow: Intutive Multimedia Control is a project aimed at revolutionizing the way users interact with digital media. Leveraging cutting-edge technologies and innovative design principles, this project introduces a media player that incorporates intuitive interactions and augments the user's senses. By merging the physical and digital realms, the Intutive Multimedia Interactor Media Player provides an immersive and seamless media experience. The key objective of this project is to enhance user engagement and convenience while consuming digital media content. The Intutive Multimedia Interactor Media Player utilizes advanced gesture recognition through image processing techniques to enable users to control media playback and access content effortlessly. Users can, pause, play, forward, rewind, adjust volume, and perform other playback functions using specific hand gestures.
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Liu, Songling, Richard T. Premont, and Don C. Rockey. "G-protein-coupled Receptor Kinase Interactor-1 (GIT1) Is a New Endothelial Nitric-oxide Synthase (eNOS) Interactor with Functional Effects on Vascular Homeostasis." Journal of Biological Chemistry 287, no. 15 (January 31, 2012): 12309–20. http://dx.doi.org/10.1074/jbc.m111.320465.
Abstract:
Endothelial cell nitric-oxide (NO) synthase (eNOS), the enzyme responsible for synthesis of NO in the vasculature, undergoes extensive post-translational modifications that modulate its activity. Here we have identified a novel eNOS interactor, G-protein-coupled receptor (GPCR) kinase interactor-1 (GIT1), which plays an unexpected role in GPCR stimulated NO signaling. GIT1 interacted with eNOS in the endothelial cell cytoplasm, and this robust association was associated with stimulatory eNOS phosphorylation (Ser1177), enzyme activation, and NO synthesis. GIT1 knockdown had the opposite effect. Additionally, GIT1 expression was reduced in sinusoidal endothelial cells after liver injury, consistent with previously described endothelial dysfunction in this disease. Re-expression of GIT1 after liver injury rescued the endothelial phenotype. These data emphasize the role of GPCR signaling partners in eNOS function and have fundamental implications for vascular disorders involving dysregulated eNOS.
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McFarland, K. N., M. N. Huizenga, S. B. Darnell, G. R. Sangrey, O. Berezovska, J. H. J. Cha, T. F. Outeiro, and G. Sadri-Vakili. "MeCP2: a novel Huntingtin interactor." Human Molecular Genetics 23, no. 4 (October 8, 2013): 1036–44. http://dx.doi.org/10.1093/hmg/ddt499.
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Subotnick, Morton, and Mark Coniglio. "An interactive performance software (Interactor)." Journal of the Acoustical Society of America 88, S1 (November 1990): S72. http://dx.doi.org/10.1121/1.2029129.
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黃家彥, 黃家彥, 林佑樺 Chia-Yen Huang, 郭昱廷 Yu-Hua Lin, 汪雅雲 Yu-Ting Kuo, 柯智群 Ya-Yun Wang, 詹景全 Chih-Chun Ke, and 林盈宏 Chying-Chyuan Chan. "TBC1D21結合蛋白RAB5C參與於精子型態生成." 輔仁醫學期刊 21, no. 1 (March 2023): 015–25. http://dx.doi.org/10.53106/181020932023032101002.
Abstract:
<p>背景與目的: 不孕是重要的公眾健康議題，造成不孕的因素其中一半與男性相關。其中造成男性不孕的一項重要病因是畸型精子症。在先前的研究中，我們以cDNA微晶片比較造精功能正常與異常的睪丸組織中各別基因的表現量。其中發現一個與不孕相關Rab GTPase激活蛋白，名為TBC1D21蛋白。TBC1D21特異的表現於減數分裂後期精細胞中。而於Tbc1d21基因剔除小鼠模式中發現嚴重精子尾部的中節區域損壞。進一步我們以蛋白質質體學方法鑑定出與TBC1D21結合蛋白。於本研究中我們聚焦於其中一個TBC1D21結合蛋白RAB5C。研究方法與結果: RAB5C蛋白表現於小鼠睪丸組織切片中的精子細胞的頂體與尾部。於成熟精子中，RAB5C蛋白濃縮於頭部頂體與散落於尾部中節區域。其中有趣的是精子經過頂體反應後，於頂體的RAB5C蛋白量明顯下降消失。最後我們利用共同免疫染色法確認RAB5C與TBC1D21共同散落於成熟精子尾部中節區域。結論:基於以上結果，我們發現TBC1D21 交互作用蛋白RAB5C參與於精子頭部頂體與尾部中節的形成。</p> <p> </p><p>Background and purpose: Infertility is a critical public health issue, and half of its causes are related to male factors. Teratozoospermia is one of major cause of male infertility. In our previous studies, we identified the TBC1 domain family member 21 (TBC1D21) gene, a Rab GTPase-activating protein (GAP), as a sterility-related gene in cDNA microarray compared to normal and spermatogenic testicular tissues. TBC1D21 is specifically expressed in post-meiotic male germ cells. Furthermore, the loss of Tbc1d21 allele in mice results in severe defects in the midpiece of the sperm’s tail. Additionally, TBC1D21 interactors were selected using proteomic assays. Herein, we focused on RAB5C, which is a TBC1D21 interactor. Methods and Results: RAB5C was localized in the acrosomal region and elongating tail in spermatids of murine testicular sections. In a mature sperm cell, RAB5C signals were concentrated in the acrosome and were scattered around the midpiece. Interestingly, RAB5C pro-tein levels decreased in the acrosome after triggering acrosomal reaction. Finally, we confirmed that the interspersed RAB5C signals were co-localized with TBC1D21 within the midpieces of the mature sperm cells. Conclusion: Based on these results, we suggest RAB5C, a TBC1D21 interactor, was involved in acrosomal and midpiece formation.</p> <p> </p>
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Weihl, Conrad C. "Another VCP interactor: NF is enough." Journal of Clinical Investigation 121, no. 12 (December 1, 2011): 4627–30. http://dx.doi.org/10.1172/jci61126.
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Ferro, Anabela, Ana Luísa Carvalho, Andreia Teixeira-Castro, Carla Almeida, Ricardo J. Tomé, Luísa Cortes, Ana-João Rodrigues, et al. "NEDD8: A new ataxin-3 interactor." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773, no. 11 (November 2007): 1619–27. http://dx.doi.org/10.1016/j.bbamcr.2007.07.012.
Dissertations / Theses on the topic "Interacteur":
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Gakovic, Milica. "Etudes fonctionnelles de Tyk2 dans la voie de signalisation de l'IFNα: analyse d'un nouvel interacteur et d'une mutation activatrice." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2007. http://tel.archives-ouvertes.fr/tel-00808013.
Abstract:
Les récepteurs des cytokines à structure α-hélicoïdale sont pour la plupart composés de deux sous-unités transmembranaires associées aux protéine tyrosine kinases de la famille Janus (Tyk2, Jak1, Jak2 et Jak3). La fixation de la cytokine à son récepteur induit une dimérisation des sous-unités ce qui entraîne l'activation des Jak par transphosphorylation. Les Jaks ainsi activées phosphorylent les facteurs de transcription STAT (Signal Transducer and Activator of Transcription) qui transloquent dans le noyau. Les tyrosine kinases Jak présentent en position N-terminale un domaine FERM (4.1-ezrin-radixin-moesin), suivi par un domaine dit 'SH2-like' et deux domaines kinases: un domaine dit 'kinase-like' (KL) à fonction régulatrice et un domaine catalytique de type tyrosine kinase en position C-terminale. L'association au récepteur se fait par la région N-terminale. Le laboratoire s'intéresse particulièrement au récepteur de l'interféron de type I (IFNα/β) composé de deux chaînes, IFNAR1 et IFNAR2, et aux kinases Tyk2 et Jak1 auxquels elles s'associent respectivement. La première partie de ma thèse a porté sur l'étude d'un nouveau partenaire de Tyk2, la protéine Pot1 (Partner of Tyk2) et de son rôle potentiel dans la voie de signalisation de l'IFNα. Plusieurs ADNc partiels de Pot1 avaient été isolés dans le laboratoire par criblage double-hybride utilisant comme appât le domaine FERM de Tyk2. Un ADNc complet de Pot1 avait été reconstruit donnant lieu à une protéine de 1003 acides aminés (aa). L'interaction entre cette protéine et les domaines FERM de Tyk2 et de Jak1 avait été confirmée par des expériences in vitro. L'analyse par northern blot de Pot1 montre une expression faible dans plusieurs tissus. L'étude de la localisation de la protéine Pot1 surexprimée avait montré une localisation cytoplasmique au niveau de vésicules non identifiées. Un des aspects de mon travail sur Pot1 a été de déterminer si l'ADNc reconstruit dans le laboratoire, appelé 'lab cDNA', correspond à un vrai transcrit. En effet, les banques de données recensent plusieurs autres transcrits issus du gène Pot1, avec une portion 3' commune et identique au 'lab cDNA', mais une région 5' divergente. Ces transcrits donnent lieu à deux isoformes ne possédant pas les 200 aa ou 250 aa en position N-terminale par rapport à la protéine de référence codée par le 'lab cDNA'. De plus, l'unique protéine murine (mPot1) recensée dans les banques de données ne possède pas les 100 aa en N-terminal par rapport à la protéine humaine de référence. Pour analyser l'expression de différents transcrits, j'ai amplifié l'ADNc de cellules humaines HEK293T avec des primers me permettant de 12 distinguer les différents transcrits. Ces expériences ont permis de confirmer l'expression du transcrit correspondant au 'lab cDNA' et codant pour une isoforme de 1003 aa (112 kDa). Par la suite j'ai étudié la localisation de la protéine Pot1 murine dans les cellules surexprimant mPot1. J'ai observé que mPot1 se trouve dans des vésicules cytoplasmiques, tout comme la protéine humaine, et semble être associée à la membrane de ces vésicules. Toutefois, nous ne pouvons pas écarter la possibilité de localisation inadéquate dû à la forte surexpression de mPot1. Il sera nécessaire de confirmer cette observation par l'analyse de la localisation de la protéine endogène. A ce jour les anticorps disponibles ne permettent pas sa détection. Afin d'évaluer le rôle de Pot1 dans la voie de signalisation de l'IFNα, j'ai mesuré la réponse à l'IFNα de cellules déplétées en Pot1 par interférence à l'ARN. J'ai mesuré la phosphorylation des protéines STAT et l'induction d'un gène rapporteur. Ces expériences ont montré que, dans ce système, la diminution de l'expression de Pot1 n'a pas d'effet sur la signalisation par l'IFNα. Afin d'éclairer la fonction de Pot1, de nouveaux interacteurs de Pot1 ont été recherchés par criblage double-hybride. Parmi les 14 protéines identifiées à haut niveau de confiance, nous nous sommes particulièrement intéressés à GIT1 (G protein-coupled receptor kinase interactor), une protéine adaptatrice impliquée dans de nombreux processus cellulaires, tels que l'internalisation de récepteurs, la signalisation induite par l'EGF (epidermal growth factor) et l'angiotensine II ainsi que la migration cellulaire. Afin d'analyser le rôle éventuel de GIT1 dans la signalisation par l'IFNα, j'ai mesuré plusieurs paramètres (internalisation des sous-unités du récepteur, phosphorylation des STAT, induction d'un gène rapporteur) dans des cellules surexprimant ou déplétées en GIT1. Les résultats obtenus ont écarté l'hypothèse d'une implication de GIT1 dans la réponse transcriptionnelle à l'IFNα. La deuxième partie de mon travail a porté sur l'étude de la mutation V678F introduite dans la protéine Tyk2.Cette substitution est située dans le domaine KL et correspond à la mutation V617F de Jak2, décrite comme étant à l'origine de la Polycythemia vera. La P. vera, ou maladie de Vaquez, est une maladie myéloproliférative caractérisée par une hyperproduction d'érythrocytes et leur hypersensibilité à l'érythropoiétine (Epo). Il a été montré que la mutation V617F induit une augmentation de l'activité kinase de base de Jak2. De même, Jak2V617F induit une prolifération indépendante de facteurs de croissance des cellules murines BaF3, confirmant son potentiel transformant. Toutefois, il a été montré que 13 Jak2V617F nécessite la coexpression d'un récepteur homodimérique, tel que récepteur à l'Epo, pour exercer une activité transformante maximale. Les questions que nous nous sommes posées sont les suivantes: 1) quel est l'effet de la substitution V678F sur l'activité catalytique de Tyk2? 2) quel est l'effet du mutant Tyk2V678F sur la signalisation par l'IFNα? 3) le mutant Tyk2V678F aurait-il un effet plus marquant ou délétère s'il est placé dans un contexte de récepteur homodimérique? A cet effet, nous avons établi, à partir de cellules Tyk2-déficientes, des clones stables exprimant la protéine sauvage ou mutante. Nos résultats montrent que la mutation V678F augmente in vivo et in vitro la capacité de Tyk2 à s'auto-phosphoryler. Par la suite, j'ai mesuré la phosphorylation sur tyrosine des protéines STAT en réponse à l'IFNα. Aucune différence de niveau de phosphorylation de STAT1/2/5 n'a pu être décélée entre les cellules exprimant la protéine sauvage et les cellules exprimant le mutant Tyk2V678F. Par contre, j'ai mis en évidence une phosphorylation basale de STAT3 augmentée en présence de Tyk2V678F. Pour déterminer si cette phosphorylation basale de STAT3 corrèle avec une augmentation de son activité transcriptionnelle, j'ai analysé l'activité transcriptionelle de STAT3 à l'aide d'un gène rapporteur. Les résultats montrent que, dans les cellules exprimant le mutant Tyk2V678F, STAT3 possède une activité transcriptionelle augmentée. Afin d'étudier l'effet du mutant Tyk2V678F placé dans un contexte de récepteur homodimérique, j'ai utilisé des cellules exprimant un récepteur chimérique comprenant l'ectodomaine du récepteur à l'Epo fusionné aux régions transmembranaire et cytoplasmique de la chaîne IFNAR1 (EpoR/R1). A l'aide de ces cellules, j'ai pu confirmer que l'expression du mutant Tyk2V678F engendre une phosphorylation basale de STAT3. De plus, dans ce contexte de récepteur homodimérique, suite à stimulation par le ligand Epo, le mutant Tyk2V678F induit une augmentation ultérieure de la phosphorylation de STAT1, STAT3 et STAT5. Nous avons aussi voulu comparer directement le niveau de phosphorylation de Tyk2V678F et de STAT3 dans différents contextes de récepteurs. Les résultats obtenus montrent que la protéine Tyk2V678F est plus phosphorylée basalement dans les cellules exprimant le récepteur homodimérique EpoR/R1. Ceci est probablement la conséquence d'une transphosphorylation plus efficace de deux kinases mutantes juxtaposées. Par contre, la phosphorylation de STAT3 ne corrèle pas directement avec le niveau d'expression du mutant Tyk2V678F, ce qui suggère une absence de corrélation linéaire entre l'activation de Tyk2 et et de STAT3. 14 En conclusion, nous avons montré que la mutation V678F augmente l'activité catalytique de Tyk2. De plus, le mutant acquiert la capacité de phosphoryler STAT3 et ceci en absence du ligand. Cependant, le mutant Tyk2V678F n'affecte pas la réponse à l'IFNα en terme de phosphorylation de Jak1, STAT1 et STAT2. Ces résultats démontrent une interaction fonctionnelle étroite entre Tyk2 et STAT3. Etant donné que STAT3 constitutivement actif exerce des propriétés oncogéniques et que STAT3 est phosphorylé dans de nombreux cancers, il est possible de prédire aussi un rôle oncogénique pour Tyk2 constitutivement active. Récemment, il a été suggéré qu'un polymorphisme de Tyk2, P1104A, pourrait être associé à la présence de tumeurs. Cette substitution est située dans le domaine tyrosine kinase au sein d'une hélice α présente uniquement dans les membres de la famille Jak. Nous avons introduit cette mutation dans Tyk2 et analysé son effet sur l'activité kinase. Les résultats montrent que le mutant Tyk2P1104A est incapable de s'autophosphoryler in vitro. Toutefois, en réponse à l'IFNα, aucune différence du niveau de phosphorylation de STAT1/2 /3 n'est décélée dans les cellules exprimant Tyk2P1104A par rapport aux cellules exprimant la protéine sauvage. Ces résultats suggèrent que la mutation P1104A abolit la capacité autophosphorylante de l'enzyme, mais n'affecte pas l'activité enzymatique induite par l' l'IFNα envers d'autres substrats in vivo. Ces résultats préliminaires devront être renforcés par des études plus approfondies de l'effet de la mutation P1104A sur la fonction que Tyk2 exerce au sein du récepteur de l'IFNα/β ainsi qu'au sein d'autres récepteurs de cytokines de la réponse immune.
2
Gakovic, Milica. "Etudes fonctionnelles de Tyk2 dans la voie de signalisation de l’IFNalpha : analyse d’un nouvel interacteur et d’une mutation activatrice." Paris 6, 2007. https://tel.archives-ouvertes.fr/tel-00808013.
Abstract:
Les tyrosines kinases de la famille Jak (Tyk2, Jak1-3) sont impliquées dans la signalisation par les cytokines hélicoïdales. Une partie de ma thèse a porté sur l’étude de Pot1, un nouvel interacteur de Tyk2. Afin d’évaluer le rôle de Pot1 dans la voie de signalisation de l’IFN, j’ai mesuré la réponse à l’IFN de cellules déplétées en Pot1 en évaluant la phosphorylation des STATs et l’induction d’un gène rapporteur. La diminution de l'expression de Pot1 n’a pas d’effet sur la signalisation par l’IFN. La deuxième partie de mon travail a porté sur l’étude de la substitution V678F dans la Tyk2. Nous avons établi, à partir de cellules Tyk2-déficientes, des clones stables exprimant la protéine sauvage ou mutante. Nous avons aussi analysé le mutant Tyk2V678F associé à un récepteur artificiel de type homodimérique. Nos résultats montrent que la mutation V678F augmente in vivo et in vitro la capacité de Tyk2 à s’auto-phosphoryler, cela plus fortement dans le cas du récepteur homodimérique. De plus, le mutant acquiert la capacité de phosphoryler STAT3 en absence de ligand mais n’affecte pas la réponse à l’IFN en terme de phosphorylation de Jak1 et STAT1/2Tyk2 is a member of the Jak family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2), which are indispensable components of -helical cytokine signaling cascades. Receptors for - helical cytokines are mostly made of two transmembrane subunits that associate with Jaks. Ligand bridging of two receptor chains brings together the associated Jaks, enabling their activation by transphosphorylation. Activated Jaks phosphorylate the STATs (Signal Transducer and Activator of Transcription) which translocate into the nucleus to drive gene expression. The Jaks have an N-terminal FERM (band 4. 1-ezrin-radixin-moesin) domain, followed by an "SH2-like" domain and two kinase domains: a kinase-like (KL) domain and the catalytic tyrosine-kinase domain. The FERM and SH2-like domains are necessary for receptor binding. The KL domain has no catalytic activity, but plays an important regulatory role. The laboratory is particularly interested in the type I interferon (IFN/) receptor, made of two subunits IFNAR1 and IFNAR2, which bind Tyk2 and Jak1, respectively. During the first part of my thesis, I analyzed a new Tyk2 interacting protein, Pot1 (Partner of Tyk2). Pot1 was isolated in a yeast two-hybrid screen using the Tyk2 FERM domain as bait. To assess the role of Pot1 in IFNsignaling, I monitored IFN-induced response in Pot1-depleted cells by measuring STAT phosphorylation and the induction of a reporter gene. These experiments showed that, in this system, Pot1 depletion had no effect on IFN-induced signaling. A two-hybrid screen was performed with Pot1 as bait. Among the 14 proteins found with high interaction confidence, we focused on GIT1 (G protein-coupled receptor kinase interactor 1), an adaptor protein implicated in a number of cellular processes, like cell migration, receptor internalization and EGF and angiotensin II signaling. To analyze the role of GIT1 in IFNsignaling, I monitored IFN-induced receptor internalization, STAT phosphorylation and the induction of a reporter gene in GIT1-depleted cells. The results obtained allow us to exclude a role for GIT1 in type I IFN signaling. During the second part of my thesis, I analyzed the effect of the V678F substitution on Tyk2 function. This mutation, located in the KL domain, corresponds to the V617F mutation of Jak2 found at the origin of Polycythemia vera. To study the effect of the V678F mutation on Tyk2 activity, I reconstituted Tyk2-deficient cells with Tyk2 WT or the V678F mutant and monitored IFN-induced response. Our results show that the V678F mutation augments basal Tyk2 kinase activity measured in vitro. This gain-of-function leads to an increase of the basal STAT3 phosphorylation level, but has no effect on IFN-induced Jak1 and STAT1/2/5 phosphorylation. As opposed to Jak2, Tyk2 has been implicated only in signaling via heterodimeric receptor complexes. Interestingly, it has been shown that Jak2V617F needs the coexpression of a cognate homodimeric receptor to fully exert its transforming activity in the BaF3 cellular model system. Therefore, we analyzed the effect of Tyk2V678F on signaling via an artificial homodimeric receptor. To this end, we used Tyk2-deficient cells that express a chimeric receptor containing the extracellular domain of erythropoietin receptor fused to the intracellular region of IFNAR1. These cells were stably reconstituted with Tyk2WT or the V678F mutant. In this context, Tyk2V678F confers ligand hypersensitivity as seen by STAT1/3/5 phosphorylation. Moreover, the ensemble of these data point to STAT3 as a preferred substrate of Tyk2
3
Khalfallah, Riahi Sonia. "Performance dansée augmentée et installation interactive performative : possibilités et limites de la co-création." Electronic Thesis or Diss., Paris 8, 2021. http://www.theses.fr/2021PA080069.
Abstract:
Les œuvres numériques interactives remettent en question le rôle du spectateur. Il est sollicité physiquement et sensoriellement afin de l’inciter à être actif. Dans ce projet de thèse, nous mettons en avant le potentiel créatif enfui dans chaque participant à travers sa gestualité interactive dans la co-création de l’œuvre.À partir de l’exploration des différents gestes performatifs à travers les courants et les disciplines artistiques existants sous forme de performances et d’installations, nous avons identifié et créé le geste performatif recherché dans nos créations artistiques : la gestualité interactive créative et performative. Par ailleurs, dans le cadre de cette recherche-création, la réalisation de performances dansées augmentées et d’installations interactives performatives a été consolidée par l’observation et l’étude des comportements des participants afin de déterminer les possibilités et les limites de la co-création des œuvres réaliséesInteractive digital artworks question the role of the spectator. They solicit him physically and sensually in order to make him active.In this thesis project, we highlight the creative potential embedded in each participant through their interactive gestures in the co-creation of the artwork.Thanks to the exploration of the different performative gestures through existing art movement and disciplines in the form of performances and installations, we identified and created the sought performative gesture in our artistic creations : creative and performative interactive gestures. Moreover, as part of this research-creation, the realization of augmented dance performances and performative interactive installations was consolidated through the observation and the study of the participants’ behavior in order to depict the possibilities and the limits of co-creation in the created artworks
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Lindberg, Love. "Interaktionsloggning i Scania Interactor." Thesis, KTH, Maskinkonstruktion (Inst.), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-99672.
Abstract:
Scania provides a fleet management system for hauliers who want to control their fleets in an efficient way. The system includes an onboard computer with touch screen called Scania Interactor where the driver can access GPS navigation, order support, message service and other functionalities. The purpose of this thesis is to develop a concept for logging the user interaction on the Interactor and analyze the result which enables further development and optimization of the interface. A demonstration application is designed, implemented and tested for the purpose of showing the possibilities and difficulties with logging of interaction. The result shows that logging is quite easy to implement and that the amount of produced data is small and therefore not expensive to transfer via GPRS to a central server where searching and analysis can be done. On the other hand, the biggest challenge lies in the analysis and interpretation of the logged data and to apply it to the development of the interface. Logging of interaction can not answer questions about the user’s opinions but can at least point out potential flaws and areas that can be improved. Another issue related to logging of interaction is the legal aspect. Two laws have been identified and need consideration before logging can be implemented in reality.Scania tillhandahåller ett system för flottstyrning, kallat Fleet Management System, för åkerier som vill styra sina flottor på ett effektivt sätt. I Scanias system ingår på fordonssidan en fordonsdator med pekskärm kallad Interactor. På den finns ett grafiskt användargränssnitt där chauffören har tillgång till GPS-navigeringsverktyg, orderhantering, meddelandetjänst och andra funktioner för att underlätta i arbetet. Detta examensarbete har gått ut på att ta fram ett koncept för att logga interaktionen som chaufförerna har med Interactorn för att sedan analysera loggen och dra slutsatser som leder till att utvecklingen av Interactorn kan optimeras. En demonstrator har designats, implementerats och testats för att visa på möjligheter och svårigheter med interaktionsloggning. Resultatet visar att det på ett enkelt sätt går att logga interaktion med Interactorn samt att loggen som skapas inte blir särskilt stor och därmed inte så dyr att överföra med GPRS till en central enhet där sökning och analys kan utföras. Däremot ligger det en stor utmaning i att analysera och tolka loggen och sedan applicera det på utvecklingen av Interactorn. Interaktionsloggning kan inte svara på frågor om användarnas uppfattning om Interactorn men kan peka på potentiella brister och områden som kan förbättras. Den lagliga aspekten av interaktionsloggning har också tagits upp där två lagar har identifierats, personuppgiftslagen och lagen om elektronisk kommunikation. Om interaktionsloggning ska implementeras och användas i mer än fältprovsbilar måste dessa lagar tas hänsyn till.
5
Swärd, Kristofer. "Godshantering med Scania Interactor." Thesis, KTH, Maskinkonstruktion (Inst.), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-100846.
Abstract:
This thesis is about making a support for barcode readers and RFID readers on a computer mounted in heavy vehicles. The computer has several applications designed for heavy vehicles such as an order handling application. The goal was to suggest an architecture to implement a support for the readers. The architecture should be independent of which manufacturer who has made the reader hardware that was connected to the computer. At first a theoretically study was made around RFID technology and standards for the transport and supply sector. Then the architecture was developed and a demo implementation was made. The conclusion of this thesis is to implement support for barcode readers with a wedge application. The wedge application is an application that handles the communication with barcode readers and converts the barcode into key presses from a virtual keyboard. The wedge application is an application that the manufacturer of the barcode reader supplies. The user must install the drivers and wedge application for the reader. On one type of the computers the user is not allowed to install own applications. This is solved by Scania by installing drivers and wedge applications from the largest actors on the barcode reader market. The implementation of RFID readers is not as urgent as for barcode reader. RFID is mostly used in shape of smart labels. Smart labels are a combination of an RFID tag and a barcode and therefore the barcode can be used on smart labels. When and if the implementation of RFID will be made the EPC standard should be used. This is probably he standard that will be used in supply chains. The EPC standard specifies a protocol between the RFID reader and the host computer.Det här examensarbetet handlar om att göra ett stöd för streckkodsläsare och RFID-läsare till en dator monterad i en lastbil. Datorn har flera applikationer gjorda för lastbilar till exempel en orderhanteringsapplikation. Målet var att föreslå en arkitektur för att implementera stöd för läsare. Arkitekturen ska vara oberoende av vilken tillverkare som har gjort hårdvaran som kopplas till datorn. Först gjordes en teoristudie av RFID-teknologin och standarder för transport- och distributionsnätet. Sedan utvecklades arkitekturen och en demo gjordes. Slutsatsen av det här examensarbetet är att implementera stöd för streckkodsläsare med en så kallad wedge-applikation. Wedge-applikationen hanterar kommunikationen med streckkodsläsare och konverterar streckkoden till tangentbordstryckningar från ett virtuellt tangentbord. Wedge-applikationen tillhandahåller tillverkaren av streckkodsläsaren. Användaren måste installera drivrutiner och wedge-aplikationen för sin läsare. På en av datorerna är det inte tillåtet att installera egna applikationer. Detta löses genom att Scania installerar drivrutiner och wedge-applikationer från de största tillverkarna inom streckodsläsarområdet. Implementeringen av RFID-läsare är inte lika brådskande som för streckkodsläsare. RFID används oftast i form av smart labels. Smart labels är en kombination av en RFID-tag och en streckkod och därför kan streckkoden användas på en smart label. Om och när implementeringen av RFID sker så bör EPC-standarden användas. Det är troligvis denna standard som kommer att användas inom distribution. EPC-standarden specificerar ett protokoll som används mellan RFID-läsaren och värddatorn.
6
Zorman, Sarah. "Nouveau regard sur la signalisation AMPK : multiples fonctions de nouveaux interacteurs." Phd thesis, Université de Grenoble, 2013. http://tel.archives-ouvertes.fr/tel-00877237.
Abstract:
La protéine kinase activée par AMP (AMPK) est un senseur et régulateur central de l'état énergétique cellulaire, mais ces voies de signalisation ne sont pour le moment que partiellement comprises. Deux criblages non-biaisés pour la recherche de partenaires d'interaction et de substrats d'AMPK ont précédemment été réalisés dans le laboratoire. Ces derniers ont permis l'identification de plusieurs candidats (protéines), mais leur rôle fonctionnel et physiologique n'était pas encore établi. Ici nous avons caractérisé la fonction de la relation entre AMPK et quatre partenaires d'interaction : gluthation S-transferases (GSTP1 and GSTM1), fumarate hydratase (FH), l'E3 ubiquitine-ligase (NRDP1), et les protéines associées à la membrane (VAMP2 and VAMP3). Chacune de ces interactions parait avoir un rôle différent dans la signalisation AMPK, agissant en amont ou en aval de la protéine AMPK. GSTP1 et GSTM1 contribueraient à l'activation d'AMPK en facilitant la S-glutathionylation d'AMPK en conditions oxydatives moyennes. Cette régulation non-canonique suggère que l'AMPK peut être un senseur de l'état redox cellulaire. FH mitochondrial est l'unique substrat AMPK clairement identifié. Etonnamment le site de phosphorylation se trouve dans le peptide signal mitochondrial, ce qui pourrait affecter l'import mitochondrial. NRDP1, protéine pour laquelle nous avons pour la première fois développé un protocole de production de la protéine soluble, est faiblement phosphorylée par l'AMPK. L'interaction ne sert pas à l'ubiquitination d'AMPK, mais affecte le renouvellement de NRDP1. Finalement, l'interaction de VAMP2/3 avec AMPK n'implique pas d'évènement de phosphorylation ou d'activation d'un des partenaires. Nous proposons un mécanisme de recrutement d'AMPK par VAMP2/3 (" scaffold ") au niveau des vésicules en exocytose. Ce recrutement favoriserait la phosphorylation de substrats de l'AMPK à la surface des vésicules en exocytoses. Une fois mis en commun, nos résultats enrichissent les connaissances sur les voies de signalisation AMPK, et suggèrent une grande complexité de ces dernières. Plus que les kinases en amont et des substrats en aval, la régulation de la signalisation d'AMPK se fait via des modifications secondaires autres que la phosphorylation, via des effets sur le renouvellement de protéines, et probablement via un recrutement spécifique de l'AMPK dans certains compartiments cellulaires.
7
Abekhoukh-Achiou, Sabiha. "Étude de la fonction de FMRP par l'analyse de ses interacteurs." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4029.
Abstract:
Le Syndrome de l'X fragile (FXS) est la forme la plus fréquente de retard mental héréditaire. Il est causé par l’inactivation du gène FMR1 codant une RNA Binding Protein (FMRP) impliquée dans le contrôle de la traduction. Afin de mieux comprendre la fonction de FMRP, nous nous somme intéressé à ses interacteurs et mon travail s’est organisé en deux parties: la caractérisation de l'interaction FMRP/ARNm GRK4 et la caractérisation de la fonction neuronale de CYFIP1/2, deux protéines interacteurs de FMRP. Nous avons confirmé l'interaction FMRP/ARNm GRK4 et identifié une portion contenant deux motifs ACUK / WGGA, connu pour être de nouvelles cibles pour FMRP. FMRP se lie à GRK4 via son domaine RGG-box et régule négativement sa traduction. Dans les cellules granulaires du cervelet, GRK4 se lie au récepteur GABABR(GBR), induisant sa désensibilisation. Sachant l’importance de la signalisation GBR du cervelet dans la coordination motrice, un niveau élevé de GRK4 peut contribuer au déficit de l'apprentissage moteur et la coordination des mouvements dans FXS. Nous avons également caractérisé la fonction neuronale de CYFIP1/2 en induisant leur knockdown (KD). Ces protéines appartiennent au complexe WAVE (WRC) qui est impliqué dans la régulation de l’établissement de la polarité axonale et dendritique. Nous avons identifié un mécanisme de co-régulation de la transcription des ARNm codant les membres du WRC lors de l’altération de l'expression de CYFIP1/2. Le KD CYFIP1/2 modifie également neuronale ramification et connectivités. L'interaction de FMRP/CYFIP1/2 permettrait de comprendre les mécanismes impliqués dans le développement des anomalies des épines dendritiques dans FXSFragile X syndrome (FXS) is the most common form of inherited mental retardation. It is caused by the silencing of the FMR1 gene, which encodes for an RNA-binding protein (FMRP) involved in translational control. To better understand the function of FMRP, we are interested in its interactors and so my work was organized into two main parts: the characterization of the interaction between FMRP and GRK4 mRNA and the characterization of the neuronal function of CYFIP1/2, two FMRP interacting proteins. We confirmed in vivo and in vitro the FMRP/ GRK4 mRNA interaction and identified a portion containing two ACUK/WGGA motifs, known to be a novel targets for FMRP. FMRP binds this target via its RGG box domain and negatively modulates the expression of GRK4 at the translational level only in cerebellum. In cerebellar granule cells, GRK4 interacts directly with the GABAB receptor (GBR), promoting its desensitization. Since in cerebellum GBR signaling has a relevant role in motor coordination, an elevated level of GRK4 can contribute to deficits of motor learning and movement coordination in FXS. Next, we characterized the function of CYFIP1/2 in neurons by inducing their knockdown (KD). CYFIP1/2 are components of the canonical WAVE regulatory complex (WRC), important in the spatiotemporal regulation of actin dynamics to get correct axonal and dendrites polarity and branching. We identified a co-regulation of transcription of mRNA coding the WRC members when the expression of CYFIP1/2 is disturbed. KD CYFIP1/2 also alters neuronal branching. The FMRP/CYFIP1/2 interaction would allow us to understand the mechanisms involved in the development of dendritic spines abnormalities in FXS
8
Carraco, Gil Daniel Bregieiro. "Interactor factors as suppressors of mutated mitochondrial tRNA." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11479.
Abstract:
Mestrado em Biotecnologia - Biotecnologia MolecularNeste trabalho avaliou-se o efeito de mutações em tRNA mitocondrial humano usando a levedura Saccharomyces cerevisiae como modelo. Em termos genéricos S. cerevisiae é um microrganismo muito estudado e conhecido, sendo possível modificar o seu genoma de forma rápida e precisa. Como bom modelo permite estudar este tipo de doenças através da mutação dos seus genes que codificam para tRNAs através de um procedimento biobalístico. Com este procedimento é possível introduzir mutações nos genes que codificam para tRNAs mitocondriais da levedura em qualquer posição, incluindo mutações equivalentes às que são patogénicas em humanos. S. cerevisiae é também um bom modelo pois os seus mutantes que exibem deficiências respiratórias, complexas ou muitos graves, têm a capacidade de crescer pois continuam a realizar fermentação em glucose, permitindo assim efectuar estudos funcionais moleculares. Para além do referido, o uso de diferentes estirpes de S. cerevisiae com diferentes mutações permite estudar genes nucleares isolados capazes de suprimir o fenótipo anormal dos mutantes, neste caso o crescimento num meio respirável. Na primeira parte deste projecto caracterizaram-se três estirpes diferentes de S. cerevisiae wild-type, MCC123, D273-10B/1A e W303-1B e subsequentemente o efeito de substituições nos tRNAs mitocondriais com o propósito de definir uma relação entre a eficiência mitocondrial e a presença de diferentes contextos nucleares. Concluiu-se que as estirpes MCC123 e W303-1B são mais apropriadas para o estudo de mutações severas, em contraste a D273-10B/1A é mais adequada para estudar mutações mais leves. Na segunda parte estudou-se a actividade supressora da sobre-expressão dos genes que codificam para leucil-tRNA sintetase, o seu domínio C-terminal e algumas pequenas sequências em diferentes mutantes nos tRNAs incapazes de crescer em meios contendo glicerol (GlnC6T, AspC61T, GlyG30A e HisG51A). A tRNA sintetase inteira (genes de levedura e de humano) e o Cterminal têm alguma capacidade de suprimir o fenótipo anormal, mas o melhor resultado foi obtido sobre-expressando as sequências mais pequenas que codificam para péptidos de quinze aminoácidos do domínio C-terminal (β30-31 e β32-33). Outras sequências testadas não tiveram qualquer efeito supressivo. Também foi caracterizada a capacidade supressora dos factores de elongação da síntese proteica mitocondrial de levedura e humana em células carregando a mutação AspC61T. Os nossos resultados, sobre-expressando tRNA sintetases e factor EF-Tu, mostram que a capacidade catalítica não é necessária para a supressão e sugerimos que esteja envolvida uma catividade tipo chaperone.
In this work we evaluate the effect of mitochondrial tRNA mutations using the yeast Saccharomyces cerevisiae as model. This simple organism is good model since it is possible to transform the mitochondria by a biolistic procedure. This makes possible to introduce mutations at any desired position in yeast mt tRNA genes, including mutations equivalent to those that are pathogenic in humans. Yeast offers a unique possibility in that mutants exhibiting complete or very severe respiratory deficiencies can grow by fermentative metabolism on glucose and are therefore amenable to molecular functional studies. Moreover using the yeast strains with the different mutations is possible to isolate nuclear genes able to suppress the defective phenotype of the mutants, in this case to allow the growth on respirable medium (containing glycerol as unique carbon source). In the first part of this project we characterized three different S. cerevisiae wild-type strains, MCC123, D273-10B/A1 and W303-1B and subsequently the effect of mt tRNA substitutions in order to define a relationship between the mitochondrial efficiency and the presence of different nuclear backgrounds. We concluded that MCC123 and W303-1B are more appropriate to study severe mutations whereas the D273-10B/A1 is more suitable to study milder mutations. In the second part of ours experiments we studied the suppression activity overexpressing the mt leucyl-tRNA synthetases genes, it C-terminal domain and some shorter sequences in different tRNA mutants unable to grow in glycerol containing media (GlnC6T, AspC61T, GlyG30A and HisG51A). The entire tRNA synthetases (yeast and human genes) and the C-terminal have some capability of suppress the defective phenotype, but the best result was obtained overexpressing two shorter sequences coding for fifteen aminoacids from its C-terminal domain (β30-31 and β32-33). Other sequences tested did not have any supress effect. I also report a further characterization of the functionality of mt yeast and human mt protein synthesis elongation factors in their suppressing activities in cells bearing the AspC61T mutation. Our results, overexpressing either the tRNA synthetases or the EF-Tu factor, show that the catalytic function is not necessary for suppression and we suggest that a chaperone like activity is involved.
9
Di, Serio Mario. "Empirical applications of the interacted panel VAR model." Doctoral thesis, Universita degli studi di Salerno, 2018. http://hdl.handle.net/10556/3090.
Abstract:
2016 - 2017The Vector Autoregressive (VAR) Models can be considered as a dynamic multivariate extension of the univariate autoregressive models. This family of models has become very popular in macroeconomics analysis after the work of Sims(1980) and they are widely used in time series literature thanks to their flexibility. As a matter of fact, by setting appropriately a VAR model, we can describe efficiently the dynamics of the economy and provide quite accurate forecasts. During recent years, researchers developed different VAR models with the purpose to represent better the data generating process. Among these, the nonlinear VAR models have gained a central role in macroeconometric analysis in testing the theory, due to their capacity to capture a richer set of dynamics regarding current macroeconomic phenomenons. Depending on the specific model, they can allow, for example, different states (regimes) of the world, to allow the coefficients of the model to vary over time in each time unit, allowing for interactions between variables potentially revealing important information. The first paper included in this thesis is a survey which have the purpose to examine linear and nonlinear VAR models. The second and third papers present two empirical applications of the Interacted Panel VAR Model, which is a new nonlinear methodology we illustrated over the first paper. Specifically, we analyze in both papers the behavior of government spending multiplier when the interest rate is at the Zero Lower Bound (ZLB). This is a highly topical question since the outbreak of Great Recession, given that many policy makers have wondered whether fiscal stimulus would be able to help the economy to recover from recession. In particular, there exist two different and opposite theoretical predictions. New Keynesian DSGE models show that, when the interest rate is at the ZLB, a raise in government spending has a strong and positive impact on the economy. On the other side, theoretical prediction indicate very low multipliers, showing that an increase in government spending does not stimulate private activity. Although there exist many theoretical predictions about the size of government spending multiplier at the ZLB, very few empirical evidences are provided. These two paper aim to shed light on the size of the government spending multiplier at the ZLB. Among the nonlinear VAR models, we choose the Interacted (Panel) VAR Model because it offers an important advantage compared to others nonlinear approaches. Thanks to the interaction term, we are able to investigate among the entire sample. This can be done also within a time varying framework, but it implies a larger number of estimates which requires informative priors. In order to be as more agnostic as possible, we also use a Bayesian approach for inference but with uninformative priors. In the first paper we develop an Interacted VAR Model and conduct our analysis on the United States sample. In order to identify government spending shocks we use the sign restrictions approach, furthermore we use the forecast series of government spending to account for the potential effects of anticipation that can pose serious problems for the identification of government spending shocks. We find that the government spending multiplier ranges between 3.4 and 3.7 at the ZLB, while it ranges from 1.5 to 2.7 away from the ZLB. Then, we develop a Factor-Augmented IVAR (FAIVAR) model with the purpose to address another limited information problem. It confirms our results from a qualitatively point of view. As a matter of fact, the government spending multiplier ranges between 2.0 and 2.1 at the ZLB and between 1.5 and 1.8 away from the ZLB. These results are also in line with some recent studies which predict higher multipliers at the ZLB than in normal times... [edited by author]
XVI n.s.
10
Teichmann, Sophie 1981. "Characterization of BEND3, a novel interactor of deubiquitanase USP21." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/129851.
Abstract:
La monoubiquitinación de la histona H2A cumple un rol esencial en la
represión génica. Diversas enzimas desubiquitinantes (DUBs) han sido
identificadas, que remueven específicamente la ubiquitina de H2A en
distintos contextos celulares. Sin embargo poco se sabe sobre la regulación
de esta actividad enzimática y de la interrelación con la maquinaria de
ubiquitinación. En el presente trabajo hemos estudiado USP21, una DUB
específica de H2A, que modula la iniciación de la transcripción.
Hemos identificado BEND3 como interactor del USP21 nuclear. BEND3 se
distingue por la presencia de cuatro dominios BEN, está localizado en la
heterocromatina y actúa como represor de la transcripción. Hemos validado y
delimitado la interacción entre USP21 y BEND3 y hemos observado que
BEND3 está polyubiquitinado. La estabilidad proteica de BEND3 y su
localización subcelular fueron independientes de la actividad catalítica de
USP21 y los niveles de H2Aub no fueron influenciados por BEND3.
Finalmente, el análisis de la expresión génica en células madre embrionarias
de ratón revela la expresión diferencial de genes involucrados en crecimiento,
proliferación celular y ciclo celular.Monoubiquitination of histone H2A fulfills an essential role in gene repression. Several deubiquitinating enzymes (DUBs) have been identified that specifically remove ubiquitin in different cellular contexts. However, the regulation of their enzymatic activity as well as their interplay with the ubiquitination machinery are not well understood. We studied the H2A specific deubiquitinase USP21, which modulates transcriptional initiation. We identified BEND3 as interactor of nuclear USP21. BEND3 is characterized by a quadruple repeat of BEN domains, is localized to heterochromatin, and acts as a transcriptional repressor. We validated and mapped the interaction between USP21 and BEND3 and found that BEND3 is polyubiquitinated. BEND3 protein stability and subcellular localization were independent of the catalytic activity of USP21 protein, and H2Aub levels were not influenced by BEND3. Finally microarray gene expression analysis in mouse embryonic stem cells depleted for BEND3 revealed the differential expression of genes involved in cellular growth proliferation and cell cycle amongst others.
Books on the topic "Interacteur":
1
Vives, Manuel Ochoa, Vicente Hernández Abad, and Francisco Hernández Abad. Producción y tratamiento de gráficos por ordenador. Barcelona: Graduado Multimedia, 2002.
2
Hovestol, Tom. Spiritual profiling: How Jesus interacted with 8 different types of people and why it matters for you. Chicago: Moody Publishers, 2010.
3
Estes, Heide. Anglo-Saxon Literary Landscapes. NL Amsterdam: Amsterdam University Press, 2017. http://dx.doi.org/10.5117/9789089649447.
Abstract:
Literary scholars have traditionally understood landscapes, whether natural or manmade, as metaphors for humanity instead of concrete settings for people's actions. This book accepts the natural world as such by investigating how Anglo-Saxons interacted with and conceived of their lived environments. Examining Old English poems, such as Beowulf and Judith, as well as descriptions of natural events from the Anglo-Saxon Chronicle and other documentary texts, Heide Estes shows that Anglo-Saxon ideologies which view nature as diametrically opposed to humans, and the natural world as designed for human use, have become deeply embedded in our cultural heritage, language, and more.
4
Lynch, Sarah. Elementary and Grammar Education in Late Medieval France. NL Amsterdam: Amsterdam University Press, 2017. http://dx.doi.org/10.5117/9789089649867.
Abstract:
The fourteenth and fifteenth centuries saw a marked increase in the availability of elementary and grammar education in Europe. In France, that rise took the form of a unique blend of trends also seen elsewhere in Europe, ranging from Church-dominated schools to independent schools and communal groups of teachers. Lyon, long a crossroad of ideas from north and south, was home to a particularly interesting blend of approaches, and in this book Sarah Lynch offers a close analysis of the educational landscape of the city, showing how schools and teachers were organised and how they interacted with each other and with ecclesiastical and municipal authorities.
5
Segal, Joes. Art and Politics. NL Amsterdam: Amsterdam University Press, 2016. http://dx.doi.org/10.5117/9789462981782.
Abstract:
In Art and Politics, Segal explores the collision of politics and art in seven enticing essays. The book explores the position of art and artists under a number of different political regimes of the twentieth and twenty-first centuries, traveling around the world to consider how art and politics have interacted and influenced each other in different conditions. Joes Segal takes you on a journey to the Third Reich, where Emil Nolde supported the regime while being called degenerate; shows us Diego Rivera creating Marxist murals in Mexico and the United States for anti-Marxist governments and clients; ties Jackson Pollock's drip paintings in their Cold War context to both the FBI and the CIA; and considers the countless images of Mao Zedong in China as unlikely witnesses of radical political change.
6
Chacón Jaramillo, Liliana. Competitividad e innovación. Bogotá. Colombia: Universidad de La Salle. Ediciones Unisalle, 2020. http://dx.doi.org/10.19052/9789585136748.
Abstract:
Desde las diferentes líneas de investigación del Doctorado en Agrociencias de la Universidad de La Salle se presentan los retos que el sector agropecuario afronta para ser competitivo e innovador frente a los ajustes continuos en los sistemas productivos globales y colombianos. Se analiza cómo el desarrollo y el crecimiento de los territorios, de sus capacidades para interactuar y, en esencia, de sus propios atributos, de sus condiciones endógenas les permite potencializar la asociatividad en el mundo rural. De manera consecuente, se considera la importancia de apoyar la productividad y competitividad en el sector cárnico, con el fin de que se adopte una visión integral, con énfasis en las cadenas de valor, los productores y los consumidores. Se ilustra cómo la producción agropecuaria no debe ser ajena al análisis del impacto ambiental que ella misma genera, así como que es posible mejorar los sistemas educativos en regiones golpeadas por la violencia a través de una real aplicación del desarrollo sostenible y de la productividad agrícola ecológica.
7
Dekker, Henk-Jan. Cycling Pathways. NL Amsterdam: Amsterdam University Press, 2021. http://dx.doi.org/10.5117/9789463728478.
Abstract:
In an effort to fight climate change, many cities try to boost their cycling levels. They often look towards the Dutch for guidance. However, historians have only begun to uncover how and why the Netherlands became the premier cycling country of the world. Why were Dutch cyclists so successful in their fight for a place on the road? Cycling Pathways: The Politics and Governance of Dutch Cycling Infrastructure, 1920-2020 explores the long political struggle that culminated in today’s high cycling levels. Delving into the archives, it uncovers the important role of social movements and shows in detail how these interacted with national, provincial, and urban engineers and policymakers to govern the distribution of road space and construction of cycling infrastructure. It discusses a wide range of topics, ranging from activists to engineering committees, from urban commuters to recreational cyclists and from the early 1900s to today in order to uncover the long and all-but-forgotten history of Dutch cycling governance.
8
Rovida, Maria Antonietta, ed. Fonti per la storia dell'architettura, della città, del territorio. Florence: Firenze University Press, 2008. http://dx.doi.org/10.36253/978-88-8453-722-5.
Abstract:
The contributions presented at the study day held in Empoli in May 2006 – now collected in book form – are intended to provide a contribution to the debate on the relations between the teaching of history of architecture, design and historiography. Each essay addresses a specific issue, proposing an analysis and valorisation of the sources (documents, images, diaries etc.) and the resources available for research, representation and design. Taken as a whole, the collective work aims at defining a history of architecture focused on a knowledge and understanding of how, at different times and in different places, man has interacted with the geographical or environmental context to organise the physical space. A history of architecture in seamless relation with that of the city and the territory. A history of architecture that posits itself as an essential component in the design culture of architects and town planners, fostering a mode of intervention generated by a profound knowledge of the complex realities in which it takes shape.
9
Joan Llop, detectiu interactiu. Picanya: Jollibre, 2018.
10
Konopka, Allan. Identibacter interactus CD-ROM. McGraw-Hill Science/Engineering/Math, 1997.
Book chapters on the topic "Interacteur":
1
García, Raúl Ferrer. "VIP: View–Interactor–Presenter." In iOS Architecture Patterns, 285–364. Berkeley, CA: Apress, 2023. http://dx.doi.org/10.1007/978-1-4842-9069-9_6.
2
Sharma, Nipun, and Swati Sharma. "Human-Interacted Computation System." In Heterogenous Computational Intelligence in Internet of Things, 1–17. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003363606-1.
3
Martemyanov, Kirill A., Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, et al. "RIN = Ras and Rab INteractor." In Encyclopedia of Signaling Molecules, 1681. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101190.
4
Huang, Biao, and Sirish L. Shah. "Estimation of the Unitary Interactor Matrices." In Advances in Industrial Control, 37–55. London: Springer London, 1999. http://dx.doi.org/10.1007/978-1-4471-0415-5_5.
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Huang, Biao, and Sirish L. Shah. "Feedback Controller Performance Assessment: Simple Interactor." In Advances in Industrial Control, 57–64. London: Springer London, 1999. http://dx.doi.org/10.1007/978-1-4471-0415-5_6.
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Huang, Biao, and Sirish L. Shah. "Feedback Controller Performance Assessment: Diagonal Interactor." In Advances in Industrial Control, 65–80. London: Springer London, 1999. http://dx.doi.org/10.1007/978-1-4471-0415-5_7.
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Huang, Biao, and Sirish L. Shah. "Feedback Controller Performance Assessment: General Interactor." In Advances in Industrial Control, 81–97. London: Springer London, 1999. http://dx.doi.org/10.1007/978-1-4471-0415-5_8.
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Metge, Brandon J., Hawley C. Pruitt, Lalita A. Shevde, and Rajeev S. Samant. "N-Myc and STAT Interactor (NMI)." In Encyclopedia of Signaling Molecules, 3534–41. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101778.
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Metge, Brandon J., Hawley C. Pruitt, Lalita A. Shevde, and Rajeev S. Samant. "N-Myc and STAT Interactor (NMI)." In Encyclopedia of Signaling Molecules, 1–8. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101778-1.
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García, Raúl Ferrer. "VIPER: View–Interactor–Presenter–Entity–Router." In iOS Architecture Patterns, 225–83. Berkeley, CA: Apress, 2023. http://dx.doi.org/10.1007/978-1-4842-9069-9_5.
Conference papers on the topic "Interacteur":
1
Haladjian, Juan, Katharina Bredies, and Bernd Brügge. "Interactex." In UbiComp '16: The 2016 ACM International Joint Conference on Pervasive and Ubiquitous Computing. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2971763.2971776.
2
Batras, Dimitrios, Judith Guez, and Jean-François Jégo. "InterACTE." In MOCO'16: 3rd International Symposium on Movement and Computing. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2948910.2955109.
3
Anstey, Josephine, and Dave Pape. "Scripting the interactor." In the fourth conference. New York, New York, USA: ACM Press, 2002. http://dx.doi.org/10.1145/581710.581733.
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Lafay, J. F., P. Zagalak, A. Herrera, and S. Icart. "Structural results about the interactor." In 29th IEEE Conference on Decision and Control. IEEE, 1990. http://dx.doi.org/10.1109/cdc.1990.203760.
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Dion, J., L. Dugard, and J. Carrillo. "Interactor and multivariable adaptive model matching." In 26th IEEE Conference on Decision and Control. IEEE, 1987. http://dx.doi.org/10.1109/cdc.1987.272605.
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Markopoulos, Panos, Jon Rowson, and Peter Y. Johnson. "On the Composition of Interactor Specifications." In Proceedings of the BCS-FACS Workshop on Formal Aspects of the Human Computer Interface. BCS Learning & Development, 1996. http://dx.doi.org/10.14236/ewic/fac1996.9.
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Chua, David K. H., and G. M. Li. "Resource-Interacted Simulation Modeling in Construction." In Construction Congress VI. Reston, VA: American Society of Civil Engineers, 2000. http://dx.doi.org/10.1061/40475(278)17.
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Cahkus, Ece, Hatice Kose, and Gokhan Ince. "Kinect interacted drum game for disabled children." In 2014 22nd Signal Processing and Communications Applications Conference (SIU). IEEE, 2014. http://dx.doi.org/10.1109/siu.2014.6830334.
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Shahrrava, B., and J. D. Aplevich. "Stochastic adaptive control with unknown interactor matrix." In Proceedings of 2000 American Control Conference (ACC 2000). IEEE, 2000. http://dx.doi.org/10.1109/acc.2000.878719.
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"Txupito - An Interactor Component Model for Ambient HCI." In 5th International Conference on Pervasive and Embedded Computing and Communication Systems. SCITEPRESS - Science and and Technology Publications, 2015. http://dx.doi.org/10.5220/0005226200670075.
Reports on the topic "Interacteur":
1
Pedró, Francesc. Aprender en el Nuevo Milenio: Un Desafío a Nuestra Visión de las Tecnologías y la Enseñanza. Inter-American Development Bank, May 2006. http://dx.doi.org/10.18235/0011946.
Abstract:
Este documento pretende sintetizar las evidencias disponibles acerca de la emergencia de nuevas formas de aproximarse a la enseñanza y a la gestión del conocimiento fuertemente influidas por el hecho de vivir rodeados e interactuar continuamente con tecnologías de la información y de la comunicación.
2
Krikorian, O. H., B. B. Ebbinghaus, M. G. Adamson, A. S. Jr Fontes, and D. L. Fleming. Experimental studies and thermodynamic modelling of volatilities of uranium, plutonium, and americium from their oxides and from their oxides interacted with ash. Office of Scientific and Technical Information (OSTI), September 1993. http://dx.doi.org/10.2172/10190948.
3
Dancer, Helen, and Imogen Bellwood-Howard. COVID-19 and Social Differentiation in African Agriculture. Institute of Development Studies (IDS), November 2021. http://dx.doi.org/10.19088/apra.2021.044.
Abstract:
This brief presents a summary of key findings from a multi-country study of social differentiation in African agricultural value chains in the context of COVID-19. It aims to understand how trends in the politics and participation of different actors in agriculture have contributed to patterns of social differentiation, and how these patterns have interacted with the shock of COVID-19. It brings attention both to the implications of political decision-making and the effects of the pandemic on value chain structures and those working within the sector.
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Mejía Kerguelén, Sergio Luis, Emiro Andrés Suárez Paternina, Liliana Margarita Atencio Solano, and Jose Jaime Tapia Coronado. Modelo de producción sostenible de carne bovina para el Caribe húmedo. Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2020. http://dx.doi.org/10.21930/agrosavia.plegable.2020.1.
Abstract:
El sistema intensivo de producción de carne de buena calidad procura establecerse de manera orgánica o ecológica y sus componentes ambientales, sociales, de bienestar animal y aspecto económico son los pilares fundamentales. Los principales beneficios son: 1. Reducción de emisiones de gases de efecto invernadero, favorecido por el uso de árboles, arbustos y variabilidad de especies (Mejía et al. 2019). 2. Resurgimiento de especies, como árboles, arbustos, arvenses, leguminosas nativas, micro, meso y macroorganismos que van a interactuar con las pasturas y los bovinos, para formar un sistema sostenible de producción. 3. Reciclaje de nutrientes, por el aporte de residuos vegetales, raíces muertas, hojas maduras, ramas, flores y frutos que caen al suelo, provenientes de los árboles, arbustos, pastura y arvenses presentes en el modelo.
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Gafni, Yedidya, Moshe Lapidot, and Vitaly Citovsky. Dual role of the TYLCV protein V2 in suppressing the host plant defense. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7597935.bard.
Abstract:
TYLCV-Is is a major tomato pathogen, causing extensive crop losses in Israel and the U.S. We have identified a TYLCV-Is protein, V2, which acts as a suppressor of RNA silencing. Intriguingly, the counter-defense function of V2 may not be limited to silencing suppression. Our recent data suggest that V2 interacts with the tomato CYP1 protease. CYP1 belongs to the family of papain-like cysteine proteases which participate in programmed cell death (PCD) involved in plant defense against pathogens. Based on these data we proposed a model for dual action of V2 in suppressing the host antiviral defense: V2 targets SGS3 for degradation and V2 inhibits CYP1 activity. To study this we proposed to tackle three specific objectives. I. Characterize the role of V2 in SGS3 proteasomal degradation ubiquitination, II. Study the effects of V2 on CYP1 maturation, enzymatic activity, and accumulation and, III. Analyze the effects of the CYP1-V2 interaction on TYLCV-Is infection. Here we describe results from our study that support our hypothesis: the involvement of the host's innate immune system—in this case, PCD—in plant defense against TYLCV-Is. Also, we use TYLCV-Is to discover the molecular pathway(s) by which this plant virus counters this defense. Towards the end of our study we discovered an interesting involvement of the C2 protein encoded by TYLCV-Is in inducing Hypersensitive Response in N. benthamianaplants which is not the case when the whole viral genome is introduced. This might lead to a better understanding of the multiple processes involved in the way TYLCV is overcoming the defense mechanisms of the host plant cell. In a parallel research supporting the main goal described, we also investigated Agrobacteriumtumefaciens-encoded F-box protein VirF. It has been proposed that VirF targets a host protein for the UPS-mediated degradation, very much the way TYLCV V2 does. In our study, we identified one such interactor, an Arabidopsistrihelix-domain transcription factor VFP3, and further show that its very close homolog VFP5 also interacted with VirF. Interestingly, interactions of VirF with either VFP3 or VFP5 did not activate the host UPS, suggesting that VirF might play other UPS-independent roles in bacterial infection. Another target for VirF is VFP4, a transcription factor that both VirF and its plant functional homolog VBF target to degradation by UPS. Using RNA-seqtranscriptome analysis we showed that VFP4 regulates numerous plant genes involved in disease response, including responses to viral and bacterial infections. Detailed analyses of some of these genes indicated their involvement in plant protection against Agrobacterium infection. Thus, Agrobacterium may facilitate its infection by utilizing the host cell UPS to destabilize transcriptional regulators of the host disease response machinery that limits the infection.
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Durik, Amanda, Steven McGee, Linda Huber, and Jennifer Duck. The Cat is Alive and Well: Curiosity Motivates Exploration for High Interest Learners. The Learning Partnership, April 2015. http://dx.doi.org/10.51420/conf.2015.1.
Abstract:
Two studies were conducted to examine how individual interest predicts interactions with domain content and subsequent free-choice exploration. Particular focus was on learners’ acquisition of knowledge and identification of content that triggered curiosity. College student participants reported their individual interest, learned about a topic in ecology (Study 1, N = 85) and astronomy (Study 2, N = 184), responded to prompts for memory of the learning content and curiosity questions, and then had the opportunity to explore additional content related to the topic. In both studies individual interest interacted with whether students’ curiosity was triggered by particular content. In academic domains, individual interest in conjunction with curiosity may be the best predictor of continued behavioral exploration. The results are discussed in the context of the four-phase model of interest development.
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Barnes, Katrina, Barnes, Katrina, Colin Anderson, Stephanie de Chassy, Affaf Ahmed, Mudabbir Ali, Myo Min Aung, Egidio Chaimite, et al. Understanding Governance from the Margins: What Does It Mean In Practice? Institute of Development Studies (IDS), November 2021. http://dx.doi.org/10.19088/a4ea.2021.003.
Abstract:
What does governance look like ‘from below’ – from the perspectives of poor and marginalised households? How do patterns of conflict affect that? These were the questions at the heart of the Governance at the Margins research project. Over three years from 2017-2020 we worked to explore this through in-depth study in conflict-affected areas of Mozambique, Myanmar, and Pakistan. Our research teams interviewed the same people regularly over that time, finding out how they resolved problems and interacted with authorities. In this paper we connect what we found to the realities and complexities of development practice, drawing on the input of 20 experienced practitioners working in bilateral and multilateral development agencies and international NGOs, who generously gave their time to help us think through the practical implications of our wealth of findings.
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liu, cong, xing wang, rao chen, and jie zhang. Meta-analyses of the Effects of Virtual Reality Training on Balance, Gross Motor Function and Daily Living Ability in Children with Cerebral Palsy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0137.
Abstract:
Review question / Objective: Cerebral palsy (CP) is a non-progressive, persistent syndrome occurring in the brain of the fetus or infant[1]. The prevalence of CP is 0.2% worldwide, and the prevalence can increase to 20-30 times in preterm or low birth weight newborns. There are about 6 million children with CP in China, and the number is increasing at a rate of 45,000 per year. Virtual reality (VR) refers to a virtual environment that is generated by a computer and can be interacted with.VR can mobilize the visual, auditory, tactile and kinesthetic organs of CP, so that they can actively participate in the rehabilitation exercise. Information sources: Two researchers searched 5 databases, including Pubmed (N=82), Embase (N=191), The Cochrane Library (N=147), Web of Science (N=359) and CNKI (N=11).
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Sepúlveda Casadiego, Yulian Adalberto. Objetivos de desarrollo sostenible, tecnología e innovación para los agronegocios. Universidad Nacional Abierta y a Distancia, October 2021. http://dx.doi.org/10.22490/notas.4579.
Abstract:
La tecnología y la innovación están cada vez más inmersas en nuestra cotidianidad, facilitando nuestra forma de relacionarnos e interactuar con el entorno, fortalecer la productividad y la competitividad de distintas áreas de negocio. Para lograr una transición a la sostenibilidad ambiental, económica y social en los agronegocios agrícolas, pecuarios, ambientales y forestales, es necesario entender las cadenas de valor y principales actores involucrados, para así identificar las principales problemáticas o vacíos, en donde la tecnología y la innovación puedan aportar soluciones pertinentes, generando un discernimiento crítico en la postulación de alternativas de solución y toma de decisiones, puesto que se puede generar valor agregado con paquetes tecnológicos basados en equipos, procesos, productos y operaciones. Con la búsqueda, análisis y sistematización de la información, se integran herramientas teórico-prácticas con desarrollos e innovaciones tecnológicas que generen ventajas y beneficios, en pro de cumplir con la Agenda 2030 a través de la contribución a los Objetivos de Desarrollo Sostenible (ODS).
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Márquez de Arboleda, Ángela, Mariana Osuna Arciniegas, Elizabeth Cárdenas Poveda, Martha Liliana Jiménez Cardona, Camilo Andrés González Camacho, Lina Pérez Niño, Juan Carlos Yrigoyen, and Gina Catalina Loaiza Mancipe. Aprendamos Todos a Leer: guía del alumno: grado segundo 2: 2da edición. Banco Interamericano de Desarrollo, April 2023. http://dx.doi.org/10.18235/0004824.
Abstract:
Material para la consolidación de la lectura y la escritura a partir de la enseñanza explícita y sistemática de habilidades como el lenguaje oral, la fluidez, el vocabulario, la comprensión de lectura, las habilidades de transcripción que abarcan la caligrafía y la ortografía y las habilidades de composición escrita. Los libros presentan una ruta que se centra en el abordaje de tipologías textuales. En este recorrido se trabaja la silueta textual y la lectura y escritura de señales, símbolos e íconos; textos poéticos como las adivinanzas, retahílas y juegos de palabras; textos informativos básicos como mensajes, notas, cartas; textos narrativos y textos informativos como noticias y entrevistas; y se finaliza con los descriptivos, instructivos y expositivos. A través de códigos QR se proponen la lectura de textos y autores representativos de la tipología abordada, ampliando las posibilidades de interactuar con textos de calidad literaria y pertinencia pedagógica en diversos soportes que favorecen la formación de lectores.