Academic literature on the topic 'Interacted VAR'
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Journal articles on the topic "Interacted VAR"
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Radulovic, Valentina, Mara Aleksic, and Vera Kapetanovic. "Electrochemical study of varenicline adsorptive behaviour and its interaction with DNA." Journal of the Serbian Chemical Society 77, no. 10 (2012): 1409–22. http://dx.doi.org/10.2298/jsc120420073r.
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The electrochemical behaviour of novel nicotinic ?4?2 subtype receptor partial agonist varenicline (VAR) which is used for smoking cessation, was investigated in Britton-Robinson buffers (pH 2.0-12.0) by cyclic, differential pulse and square wave voltammetry at a hanging mercury drop elctrode. The influence of pH, scan rate, concentration, accumulation potential and time on peak current and potential suggested that in alkaline media the redox process was adsorption controlled. Also, the experimental value of surface coverage, G = 1.03?10-10 mol cm-2, was used to determine the conditions when VAR was fully adsorbed at the electrode surface. Having in mind potential high toxicity of VAR due to the presence of quinoxaline structure, its interaction with DNA was postulated, and studied when both compounds were in the adsorbed state at modified HMDE. Using adsorptive transfer technique, the changes in potential and decrease in normalized peak currents were observed. The estimated value of the ratio of surface-binding constants indicated that the reduced form of VAR interacted with dsDNA more strongly than the oxidized form. Subtle DNA damage under conditions of direct DNA-VAR interaction at room temperature was observed. The proposed type of interaction was an intercalation. This study used simple electroanalytical methodology and showed the potential of DNA/HMDE biosensor for investigation of genotoxic effects.
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Davis, J. V., D. R. Earhart, A. T. Leonard, and V. A. Haby. "NITROGEN AND BORON RATES FOR SELECTED BRASSICA GROWN ON EAST TEXAS ACID, SANDY SOIL." HortScience 25, no. 8 (August 1990): 858e—858. http://dx.doi.org/10.21273/hortsci.25.8.858e.
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The potential for east Texas to produce Brassica that could compete favorably with the import market exists. This study was conducted to establish optimum nitrogen and boron rates for 4 Brassica spp. grown on highly leachable east Texas soil, a Bowie series (fine-loamy, siliceous, thermic, Plinthic Paleudult). Broccoli (Brassica oleracea L. Italica, var. Green Comet), cauliflower (Brassica oleracea L. Botrytis var. White Contessa), Chinese cabbage (Brassica rapa L. Pekinensis var. Monument), and Chinese mustard (Brassica rapa L. Chinensis var. What-A-Joy) were field grown using 5 rates of N (0, 50, 100, 150, and 200 kg·ha-1) interacted with 3 rates of B (0, 1.25 and 2.5 kg·ha-1) in a complete randomized design with 3 reps. Harvested broccoli heads increased average head weight (HW), average head size (HS), and total yield (Y) for each increase of N. Cauliflower HW, HS, and Y increased up to 150 kg N ha-1. B supplementation did not statistically affect HW, HS, and Y of broccoli or cauliflower. Chinese cabbage Y increased up to 150 kg N ha-1 and produced less Y at 200 kg N ha-1 than at 50 kg N ha-1. Chinese mustard Y increased 50% for the 50 (kg·ha-1) N over no added N with additional N producing statistically equal Y. B at 1.25 (kg·ha-1) significantly increased cabbage Y, but had no effect on mustard Y.
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Bajang, Marsel Efraim, A. Rumambi, W. B. Kaunang, and D. Rustandi. "PENGARUH MEDIA TUMBUH DAN LAMA PERENDAMAN TERHADAP PERKECAMBAHAN SORGUM VARIETAS NUMBU." ZOOTEC 35, no. 2 (July 11, 2015): 302. http://dx.doi.org/10.35792/zot.35.2.2015.8526.
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THE EFFECT OF GROWING MEDIUM AND SOAKING TIME ON GERMINATION OF SORGHUM VAR. NUMBU. The present study was conducted to elaboratethe effect of the growing medium andsoaking times on germination of sorghum varieties numbu. This research has been done to learn and obtain data on the effect of the plant growth media and the soaking times of the sorghum plant sprouts. The experiment consisted of a 3x4x3 factorial design with 3 levels of growing medium (100% original soil; 50% original soil + 50% burned soil; and 100% burned out soil) and 4 levels of soaking times (0,2,4, and 6 hours). After a significant F test (where necesarry) was employed to inspect differences among group means. Statistical difference was accepted at P < 0,05. Variables measured were: germination rates, germination, and leaf counts. Research results showed that growing medium gave a significant difference (P<0,01) on germination phase and germination rates. The interaction of growing medium andsoaking times gave a significant difference on leaf counts.It can be concluded that the growing medium gave a positive response on germination phase andgermination rates; while leaf counts of Sorghum var. Numbu interacted well with growing medium of 100% original soil and all level of soaking times. Keywords: growing medium, soaking times, sorghum var. Numbu, germination.
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Itulya, Francis M., Vasey N. Mwaja, and John B. Masiunas. "Collard—Cowpea Intercrop Response to Nitrogen Fertilization, Redroot Pigweed Density, and Collard Harvest Frequency." HortScience 32, no. 5 (August 1997): 850–53. http://dx.doi.org/10.21273/hortsci.32.5.850.
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Field experiments were conducted in 1992 and 1993 to determine the effect of N fertility, cropping system, redroot pigweed (Amaranthus retroflexus L.) density, and harvesting frequency on collard (Brassica oleracea var. acephala D.C) and cowpea [Vigna unguiculata (L.) Walp.] growth. The N fertilization regimes were 0, 80, 160, and 240 kg·ha-1, applied as urea in a split application. Four weeks after crop planting, redroot pigweed was seeded at 0, 300, and 1200 seeds/m2. Between weeks 6 and 12, collard leaves were harvested at 1- to 3-week intervals. Year, N fertility, and cropping system interacted to determine collard leaf number and mass. For example, in 1992, with N at 160 kg·ha-1, collards intercropped had more total leaf mass than those monocropped. Pigweed density had no effect on collard yields, which were greatest from the 3-week harvest frequency. Cropping system and pigweed density interacted to determine cowpea vine length, shoot dry mass, and branching. The high density of pigweed caused a 56% reduction of cowpea dry mass in 1992.
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Sun, Bing, Xinru He, Fengying Long, Cui Yu, and Yongjun Fei. "The Role of PnTCP2 in the Lobed Leaf Formation of Phoebe neurantha var. lobophylla." International Journal of Molecular Sciences 23, no. 21 (October 31, 2022): 13296. http://dx.doi.org/10.3390/ijms232113296.
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A lobed leaf is a common trait in plants, but it is very rare in Lauraceae plants, including species of Phoebe. In the study of germplasm resources of Phoebe neurantha, we found lobed leaf variant seedlings, and the variation could be inherited stably. Studying the lobed leaf mechanism of P. neurantha var. lobophylla can offer insight into the leaf development mechanism of woody plants. RNA-seq and small RNA-seq analysis results showed that a total of 8091 differentially expressed genes (DEGs) and 16 differentially expressed miRNAs were identified in P. neurantha var. lobophylla. Considering previous research results, a leaf margin morphological development related miRNA, pne-miRNA319a, was primary identified as a candidate miRNA. Target gene prediction showed that a total of 2070 genes were predicted to be the target genes of differentially expressed miRNAs. GO enrichment analysis of differentially expressed target genes suggested that PnTCP2 is related to lobed leaf formation. The TRV-VIGS gene silencing of PnTCP2 led to lobed leaves in P. neurantha seedlings. The downregulation of PnTCP2 led to lobed leaves. The yeast two-hybrid test and bimolecular fluorescence complementation test confirmed that the PnTCP2 protein interacted with the PnLBD41 protein. Based on the expression analysis of gene-silenced leaves and RNA-seq and small RNA-seq analysis results, pne- miRNA319a and PnLBD41 might also play important roles in this process. In conclusion, PnTCP2 plays an important and vital role in the formation of the lobed leaves of P. neurantha var. lobophylla.
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He, Lixia, Lihong Li, Yinxia Zhu, Yu Pan, Xiuwen Zhang, Xue Han, Muzi Li, Chengbin Chen, Hui Li, and Chunguo Wang. "BolTLP1, a Thaumatin-like Protein Gene, Confers Tolerance to Salt and Drought Stresses in Broccoli (Brassica oleracea L. var. Italica)." International Journal of Molecular Sciences 22, no. 20 (October 15, 2021): 11132. http://dx.doi.org/10.3390/ijms222011132.
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Plant thaumatin-like proteins (TLPs) play pleiotropic roles in defending against biotic and abiotic stresses. However, the functions of TLPs in broccoli, which is one of the major vegetables among the B. oleracea varieties, remain largely unknown. In the present study, bolTLP1 was identified in broccoli, and displayed remarkably inducible expression patterns by abiotic stress. The ectopic overexpression of bolTLP1 conferred increased tolerance to high salt and drought conditions in Arabidopsis. Similarly, bolTLP1-overexpressing broccoli transgenic lines significantly improved tolerance to salt and drought stresses. These results demonstrated that bolTLP1 positively regulates drought and salt tolerance. Transcriptome data displayed that bolTLP1 may function by regulating phytohormone (ABA, ethylene and auxin)-mediated signaling pathways, hydrolase and oxidoreductase activity, sulfur compound synthesis, and the differential expression of histone variants. Further studies confirmed that RESPONSE TO DESICCATION 2 (RD2), RESPONSIVE TO DEHYDRATION 22 (RD22), VASCULAR PLANT ONE-ZINC FINGER 2 (VOZ2), SM-LIKE 1B (LSM1B) and MALATE DEHYDROGENASE (MDH) physically interacted with bolTLP1, which implied that bolTLP1 could directly interact with these proteins to confer abiotic stress tolerance in broccoli. These findings provide new insights into the function and regulation of bolTLP1, and suggest potential applications for bolTLP1 in breeding broccoli and other crops with increased tolerance to salt and drought stresses.
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Jesus, Janisson Batista de, Robério Anastácio Ferreira, and Dráuzio Correia Gama. "BEHAVIOR OF THE EMERGENCE OF NATIVE FOREST SEEDLINGS FOR THE PURPOSE OF RECOVERY OF THE RIPARIAN FOREST." FLORESTA 49, no. 1 (December 17, 2018): 057. http://dx.doi.org/10.5380/rf.v49i1.56202.
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Understanding the behavior of the emergence of native forest seeds is essential to achieve greater successes in forest recovery. Therefore, this study aimed to evaluate the emergence of native forest species (Cassia grandis L.F., Cecropia pachystachya Trec., Enterolobium contortisiliquum (Vell.) Morong, Guazuma ulmifolia Lam., and Libidibia ferrea var. leiostachya (Benth.) L.P.Queiroz.) in riparian areas of the Piauitinga River, in the municipality of Lagarto (state of Sergipe, Brazil). The experiment was carried out in a randomized block design (DBC) with four blocks in triple scheme (4 x 2 x 6): four forest species emerged (Cassia grandis, Enterolobium contortisiliquum, Guazuma ulmifolia, Libidibia ferrea var. leiostachya), with and without treatment to overcome dormancy, evaluated every fortnight for 90 days (6 periods). It was verified by the statistical analysis that the four species that had emergencies interacted in the two treatments used throughout the six evaluation periods. The species, in both treatments, presented a large number of seeds emerged in the first weeks after sowing, reducing over time. The species studied have a characteristic pattern of emergence over time, considering both seeds with and without treatment to overcome dormancy.
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Westcott, M. P., and N. W. Callan. "Modeling Plant Population and Rectangularity Effects on Broccoli Head Weights and Yield." Journal of the American Society for Horticultural Science 115, no. 6 (November 1990): 893–97. http://dx.doi.org/10.21273/jashs.115.6.893.
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Broccoli (Brassica oleracea L. var. italica) head weights and yields are highly sensitive to plant densities (P) and rectangularity. Broccoli cultivars were grown at four plant spacings (2.2 to 8.6 plants/m2) and four N rates (O to 336 kg N/ha) in 1986 and 1987. In 1988, plug spacings, as above, were factorially combined with treatments of one, two, or three plants per plug. Head weight (w) data were fitted to the reciprocal model: 1/w = a + bp and the exponential model: w = AKP, where a, b, A, and K are constants. Nitrogen rate did not interact with p. In 1986 and 1987, both the reciprocal and exponential models fit the w data (expressed as w relative to wmax for each cultivar) with highly significant R2 values of 0.525 to 0.605. Yield equations derived from these models were asymptotic. In 1988, clumping (multiple plants per plug) reduced head weights but interacted with plant density. Only the exponential model could account for the assumption that clumping effects diminish as plant densities increase; the reciprocal model predicted the opposite effect. The exponential model was expanded to the form: w = CAKP, where C is proportionate reduction of w due to clumping. Derived yield models were asymptotic for the reciprocal model and parabolic for the exponential model.
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Mustarichie, Resmi, Sandra Megantara, and Nyi Mekar Saptarini. "IN-SILICO STUDY OF BIOACTIVE COMPOUNDS OF NATURAL MATERIALS AS A JAK- SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION INHIBITOR FOR ANTI-ALOPECIA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (November 1, 2017): 331. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.21118.
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Objective: This study aims to examine the compounds contained in herbs for the treatment of anti-alopecia by in-silico computation.Methods: JAK (Janus Kinase) regulates the activation of key hair follicle populations such as the hair germ and improves the inductivity of cultured human dermal papilla cells by controlling a molecular signature enriched in intact, fully inductive dermal papillae. JAK2 which was a member of Janus family was used in this study as a receptor (PDB code: 4C61) and 15 compounds normally found in five herbals traditionally used as hair growth as ligands. Molecular modeling of bioactive compounds was performed using MarvinSketch and Prediction of physicochemical properties by ligand scout software. Molecular docking was performed using ligand scout, AutoDock Vina, and PyMOL. Binding affinity (Ei), inhibition constant (Ki), hydrogen bond interaction, and hydrophobic interaction were evaluated to find which of herbs potentially for anti-alopecia.Results: Among 15 compounds studied three of them, 6-hydroxy genistein, coreximine, and scoulerine interacted well with JAK2’s active pocket so it can inhibit JAK- signal transducer and activator of transcription. 6-hydroxy genistein interacted with Asp994, Gly993 Met929, Val863, Leu983, Ala880, and Leu855 whereas coreximine and scoulerine interacted with Leu932, Pro933, Tyr931 and Pro933, Tyr931, Ala880, Val863, Leu983, Leu855, respectively.Conclusion: These results predicted that three compounds, namely, 6-hydroxy genistein, coreximine, and scoulerine which come from Dadap leaves (Erythrina variegata var. orientalis (L.) Merr.) were strongly had the link with JAK2 indicating that this plant extract may be used as hair growth agent/ anti-alopecia. As compounds studied was based on the literature survey, our results suggest compounds from six herbals studied should firstly be tested in-vivo for its anti-alopecia activity, fractionated, elucidated, to check as to whether their compounds responsible for anti-alopecia using the method developed in this paper.
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Zhao, Xuehui, Xiaolun Han, Qingjie Wang, Xuxu Wang, Xiude Chen, Ling Li, Xiling Fu, and Dongsheng Gao. "EARLY BUD BREAK 1 triggers bud break in peach trees by regulating hormone metabolism, the cell cycle, and cell wall modifications." Journal of Experimental Botany 71, no. 12 (March 9, 2020): 3512–23. http://dx.doi.org/10.1093/jxb/eraa119.
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Abstract In a previous study we identified EARLY BUD BREAK 1 (EBB1), an ERF transcription factor, in peach (Prunus persica var. nectarina cultivar Zhongyou 4); however, little is known of how PpEBB1 may regulate bud break. To verify the function of PpEBB1 in bud break, PpEBB1 was transiently transformed into peach buds, resulting in early bud break. Bud break occurred earlier in PpEBB1-oe poplar (Populus trichocarpa) obtained by heterologous transformation than in wild type (WT), consistent with the peach bud results, indicating that PpEBB1 can promote bud break. To explore how PpEBB1 affects bud break, differentially expressed genes (DEGs) between WT and PpEBB1-oe poplar plants were identified by RNA-sequencing. The expression of DEGs associated with hormone metabolism, cell cycle, and cell wall modifications changed substantially according to qRT-PCR. Auxin, ABA, and total trans-zeatin-type cytokinin levels were higher in the PpEBB1-oe plants than in WT plants, while the total N6-(Δ 2-isopentenyl)-adenine-type cytokinins was lower. Yeast two-hybrid and bimolecular fluorescence complementation assays verified that a cell wall modification-related protein (PpEXBL1) interacted with PpEBB1 suggesting that PpEBB1 could interact with these cell wall modification proteins directly. Overall, our study proposed a multifaceted explanation for how PpEBB1 regulates bud break and showed that PpEBB1 promotes bud break by regulating hormone metabolism, the cell cycle, and cell wall modifications.
Dissertations / Theses on the topic "Interacted VAR"
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Di, Serio Mario. "Empirical applications of the interacted panel VAR model." Doctoral thesis, Universita degli studi di Salerno, 2018. http://hdl.handle.net/10556/3090.
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2016 - 2017The Vector Autoregressive (VAR) Models can be considered as a dynamic multivariate extension of the univariate autoregressive models. This family of models has become very popular in macroeconomics analysis after the work of Sims(1980) and they are widely used in time series literature thanks to their flexibility. As a matter of fact, by setting appropriately a VAR model, we can describe efficiently the dynamics of the economy and provide quite accurate forecasts. During recent years, researchers developed different VAR models with the purpose to represent better the data generating process. Among these, the nonlinear VAR models have gained a central role in macroeconometric analysis in testing the theory, due to their capacity to capture a richer set of dynamics regarding current macroeconomic phenomenons. Depending on the specific model, they can allow, for example, different states (regimes) of the world, to allow the coefficients of the model to vary over time in each time unit, allowing for interactions between variables potentially revealing important information. The first paper included in this thesis is a survey which have the purpose to examine linear and nonlinear VAR models. The second and third papers present two empirical applications of the Interacted Panel VAR Model, which is a new nonlinear methodology we illustrated over the first paper. Specifically, we analyze in both papers the behavior of government spending multiplier when the interest rate is at the Zero Lower Bound (ZLB). This is a highly topical question since the outbreak of Great Recession, given that many policy makers have wondered whether fiscal stimulus would be able to help the economy to recover from recession. In particular, there exist two different and opposite theoretical predictions. New Keynesian DSGE models show that, when the interest rate is at the ZLB, a raise in government spending has a strong and positive impact on the economy. On the other side, theoretical prediction indicate very low multipliers, showing that an increase in government spending does not stimulate private activity. Although there exist many theoretical predictions about the size of government spending multiplier at the ZLB, very few empirical evidences are provided. These two paper aim to shed light on the size of the government spending multiplier at the ZLB. Among the nonlinear VAR models, we choose the Interacted (Panel) VAR Model because it offers an important advantage compared to others nonlinear approaches. Thanks to the interaction term, we are able to investigate among the entire sample. This can be done also within a time varying framework, but it implies a larger number of estimates which requires informative priors. In order to be as more agnostic as possible, we also use a Bayesian approach for inference but with uninformative priors. In the first paper we develop an Interacted VAR Model and conduct our analysis on the United States sample. In order to identify government spending shocks we use the sign restrictions approach, furthermore we use the forecast series of government spending to account for the potential effects of anticipation that can pose serious problems for the identification of government spending shocks. We find that the government spending multiplier ranges between 3.4 and 3.7 at the ZLB, while it ranges from 1.5 to 2.7 away from the ZLB. Then, we develop a Factor-Augmented IVAR (FAIVAR) model with the purpose to address another limited information problem. It confirms our results from a qualitatively point of view. As a matter of fact, the government spending multiplier ranges between 2.0 and 2.1 at the ZLB and between 1.5 and 1.8 away from the ZLB. These results are also in line with some recent studies which predict higher multipliers at the ZLB than in normal times... [edited by author]
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Waldhober, Marjolein. "Coördinatie in interdependente situaties over de afweging van directe uitkomsten versus uitkomsten op lange termijn /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/73057.
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Hoek, Aukje Anna Heleen van. "Internationale mobiliteit van werknemers een onderzoek naar de interactie tussen arbeidsrecht, EG-recht en IPR aan de hand van de Detacheringsrichtlijn /." Den Haag : Amsterdam : Sdu Uitgevers ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/82782.
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Boidou, Blaise Noël. "Facteurs d'influence de l'impact d'un usage partagé du tableau blanc interactif sur la performance scolaire dans un établissement d'enseignement secondaire général de Côte-d'Ivoire." Thesis, Cergy-Pontoise, 2019. http://www.theses.fr/2019CERG1003.
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Grâce au numérique, de nombreux dispositifs ont fait leur apparition dans les salles de classe et offrent ainsi la possibilité de multiplier les supports pédagogiques dans le processus d’enseignement/apprentissage. Le Tableau Blanc Interactif ou Tableau Numérique Interactif (TBI/TNI) en fait partie. Aussi, semble-t-il judicieux d’interroger les facteurs qui influencent l’effet d’un tel dispositif sur la performance scolaire, au regard des résultats contradictoires des études scientifiques sur la question.Ce travail de recherche doctorale est une recherche mixte, alliant à la fois des données quantitatives et qualitatives. A la suite de la revue de littérature, elle tente donc de répondre à la problématique suivante : Quels sont les facteurs qui influencent l’impact de l’usage du Tableau Blanc Interactif (TBI) sur la performance des élèves ?Avant la mise en œuvre de la recherche expérimentale, les hypothèses de départ présumaient que dans un processus d’enseignement/apprentissage médié par le TBI, la performance scolaire des élèves est influencée par le style d’apprentissage de l’élève d’une part, et d’autre part, qu’elle est fonction du type de motivation à l’égard du TBI.En vue de confronter ces hypothèses susmentionnées à la réalité du terrain, une procédure expérimentale de type pré-test/post-test, exécutée en deux phases, consistant à une situation d’enseignement/apprentissage sans le TBI et ensuite avec le TBI, a été menée, afin de mesurer la performance scolaire des élèves.Pour recueillir les données, les outils que sont le questionnaire, un test d’identification du style d’apprentissage selon le modèle VAK (Visuel, Auditif, Kinesthésique), les entretiens individuels semi-dirigés, une échelle de motivation et des observations in situ ont été utilisés.Suite à l’analyse des résultats obtenus à partir des alternatives non paramétriques du test de Khi2 et du test t de Student pour des échantillons appariés, des différences significatives sont observées au niveau de la performance des élèves de style d’apprentissage visuel, contrairement aux élèves ayant d’autres styles d’apprentissage majeur.L’impact de l’intervention du TBI dans le processus d’enseignement-apprentissage serait également fonction du genre et de la motivation de l’élève vis-à-vis du TBI. En effet, on constate que les élèves de sexe masculin et les élèves ayant une motivation autodéterminée à l’égard de l’outil technologique ont vu leurs performances augmenter significativementThanks to digital technology, many devices have appeared in classrooms and offer the possibility of multiplying teaching aids in the teaching / learning process. The interactive whiteboard (TBI / TNI) is one of them. Thus, it seems judicious to question the factors that influence the effect of such a device on school performance, given the contradictory results of scientific studies on the subject.This doctoral research work is a mixed research, combining both quantitative and qualitative data. As a result of the literature review, she tries to answer the following question: What are the factors that influence the impact of the use of the Interactive Whiteboard (IWB) on student performance?Prior to the implementation of experimental research, initial assumptions assumed that in an interactive whiteboard-mediated teaching / learning process, students' academic performance is influenced by the student's learning style of learning. on the one hand, and on the other, that it is a function of their degree of motivation with regard to the interactive whiteboard.In order to compare these above-mentioned hypotheses with the reality on the ground, a two-phase experimental procedure consisting of a teaching / learning situation without the interactive whiteboard and then with the interactive whiteboard was conducted in order to measure student academic performance.To collect the data, the tools that are the questionnaire, a test of identification of the learning style according to the model VAK (Visual, Auditory, Kinesthetic), the semi-directed individual interviews, a scale of motivation and observations in situ have been used.Following the analysis of the results obtained from the nonparametric alternatives of the Khi2 test and Student's t test for paired samples, significant differences are observed in the performance of visual learning style students, unlike students with other major learning styles.The impact of the intervention of the whiteboard in the teaching-learning process would also depend on the student's gender and motivation towards the whiteboard. Indeed, we find that male students and students with a self-determined motivation for the technological tool have seen their performance increase significantly
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Trolle, Anna-Lena. ""Att föräldrarna får vara sig själva är den stora vinsten" : en studie med betoning på den kortare inskolningsmodellen i förskolan." Thesis, Södertörns högskola, Lärarutbildningen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-5527.
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I have examined acclimatization models in pre-school. My emphasis is on the shorter acclimatization models. To begin pre-school is a big change, not only for small children, for the whole family as well. It is important to get a good acclimatization in pre-school, and one of the things it takes to achieve that is to interact with the parents. The reason why I chose this subject was because we have not studied much literature about this subject during our education to become pre-school teachers. I have intervjued five pedagogues about their experiences of the short acclimatization model. My aim is to find out why the pedagogues choose to apply the brief model. My questions are following: What are the benefits with the short acclimatization model? How do the pedagogues experience the parents participation during the acclimatization? How are the flexibility on the number of days wich the acclimatization is calculate to go on? When I was studing the results of my intervjues I come to the conclusion that having a good relationship with the parents is very important. Childrens security and needs, and the pedagogues responsibility are all parts of eachother and have to exist because the acclimatization of the children are going to be as good as possible.
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Baal, Petrus Hendrikus Maria van. "Computer simulations of criminal deterrence : from public policy to local interaction to individual behaviour = Afschrikking onderzocht met computersimulaties : van beleid en lokale interactie tot individueel gedrag /." [Den Haag] : Boom, 2004. http://www.gbv.de/dms/sbb-berlin/386878234.pdf.
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Pellegrino, Giovanni. "Uncertainty and Monetary Policy: Assessing their Nonlinear Interactions." Doctoral thesis, 2016. http://hdl.handle.net/11562/936395.
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Questa tesi esamina le interazioni tra l'incertezza e la politica monetaria mediante l'utilizzo di metodi econometrici non lineari. Si compone di tre capitoli distinti.
Il primo capitolo si occupa degli effetti degli stimoli inattesi (shock da ora in avanti) di politica monetaria condizionali a diversi livelli di incertezza. Sulla base della letteratura teorica, diverse spiegazioni si pensa siano in grado di ridurre l'efficacia della politica monetaria in tempi incerti (ad esempio, l'esistenza di opzioni reali, un differente comportamento price-maker delle imprese e un maggiore risparmio precauzionale). Al fine di valutare empiricamente le supposizioni teoriche si stima un modello Interacted-VAR non lineare dove, in maniera innovativa rispetto alla letteratura, si modella la variabile condizionante - un indicatore di incertezza nel mio caso - endogenamente nel VAR. Questo implica la necessità di adottare le funzioni di risposta generalizzate (GIRFs, dall'inglese Generalized Impulse Response Functions) à la Koop et al. (1996). I risultati suggeriscono che gli shock di politica monetaria sono significativamente meno efficaci in tempi incerti, con le reazioni di picco di diverse variabili reali circa due terzi più lievi di quelle durante i periodi tranquilli. Trovo anche che l'incertezza diminuisce dopo uno shock di politica monetaria espansiva. Inoltre, mostro che, coerentemente con i risultati teorici di Vavra (2014), la reazione dei prezzi risulta più grande durante i periodi di maggiore incertezza a livello di impresa.
Il secondo capitolo (lavoro congiunto con G. Caggiano e E. Castelnuovo) si interessa dell'impatto di aumenti inattesi (shock) di incertezza in presenza di un tasso di interesse a breve periodo pari a zero (in breve ZLB, dall'inglese zero lower bound), una situazione in essere negli Stati Uniti a partire dal dicembre 2008. Diversi recenti studi teorici suggeriscono che, in questa evenienza, gli shock di incertezza dovrebbero generare un calo molto più grande e persistente dell'attività reale (si veda Fernandez-Villaverde et al. (2015), Johannsen (2013), Nakata (2013), and Basu and Bundick (2014, 2015)). Tuttavia, sul lato empirico, non è stata ancora proposta alcuna analisi che modelli esplicitamente la non linearità degli effetti reali degli shock di incertezza dovuta allo ZLB. A questo scopo, ci si avvale di un parsimonioso modello Interacted-VAR non lineare allo scopo di valutare empiricamente le predizioni teoriche. I risultati mostrano che gli effetti recessivi degli shock di incertezza sono statisticamente maggiori in presenza dello ZLB, con differenze che sono economicamente importanti. Si mostra che tali differenze non sono dovute al verificarsi contemporaneo della Great Recession.
Il terzo capitolo ritorna sull'argomento del capitolo 1, con l'obiettivo di indagare sulle ragioni strutturali alla base della minore efficacia degli shock di politica monetaria durante i tempi incerti. A questo scopo si adotta un affermato modello DSGE (dall'inglese Dynamic Stochastic General Equilibrium) Neo-Keynesiano. In particolare, si propone una semplice strategia econometrica per stimare con metodo Minimum Distance il modello DSGE condizionalmente a due regimi identificati sulla base dei dati per mezzo di modello Threshold VAR. Questa strategia poi si applica al modello di Altig, Christiano, Eichenbaum e Lindé (ACEL, 2011). Si trova che il modello di ACEL risulta essere notevolmente in grado di eguagliare le risposte del VAR, soprattutto in tempi tranquilli. Questa performance è guidata da dei valori stimati per alcuni parametri strutturali del tutto differenti tra i due regimi. In particolare, una maggiore pendenza della curva di Phillips Neo-Keynesiana, un maggior costo per variare il tasso di utilizzo del capitale, e un minore grado di abitudini nel consumo sono i principali driver della capacità del modello di predire inferiori effetti reali degli shock di politica monetaria in periodi di elevata incertezza.This thesis assesses the interactions between uncertainty and monetary policy by means of nonlinear econometric methods. It consists of three separate chapters. The first chapter is concerned with the effects of monetary policy shocks conditional on different levels of uncertainty. On the basis of the theoretical literature, several explanations are thought to be able to reduce the effectiveness of monetary policy during uncertain times (e.g., real option effects, firm-price setting behavior and precautionary savings). In order to empirically assess theoretical predictions I estimate a nonlinear Interacted VAR model, where, in a novel way with respect to the literature, I model the conditioning indicator - uncertainty, in my case, which discriminate "high" from "low" uncertainty states - endogenously in the VAR. This implies the necessity to adopt the Generalized Impulse Response Functions à la Koop, Pesaran and Potter (1996). This strategy enables me to consider both the possible endogenous reaction of uncertainty to the policy shock and its feedbacks on the dynamics of the system. My findings suggest that monetary policy shocks are significantly less effective during uncertain times, with the peak reactions of a battery of real variables being about two-thirds milder than those during tranquil times. I also find that uncertainty decreases after an expansionary monetary policy shock. Further, I show that, consistently with Vavra's (2014) predictions, the reaction of prices appears greater during firm-level uncertain times. The second chapter (coauthored with G. Caggiano and E. Castelnuovo) is concerned with the impact of uncertainty shocks at the zero lower bound (ZLB), which has been hit since December 2008 in the U.S. On the theoretical side, several recent studies suggest that when monetary policy is constrained by the ZLB, uncertainty shocks should generate a much larger and persistent drop in real activity (see Fernandez-Villaverde, Guerron-Quintana, Kuester, and Rubio-Ramirez (2015), Johannsen (2013), Nakata (2013), and Basu and Bundick (2014, 2015)). However, on the empirical side, no analysis explicitly modeling the nonlinearity of the real effects of uncertainty shocks due to the ZLB has been proposed so far. To this aim we employ a parsimonious nonlinear Interacted-VAR model to examine whether the real effects of uncertainty shocks are greater when the economy is at the ZLB. Our results show that the contractionary effects of uncertainty shocks are statistically larger when the ZLB is binding, with differences that are economically important. Such differences are shown not to be driven by the contemporaneous occurrence of the Great Recession. The third chapter returns on the argument of Chapter 1 with the aim of enquiring on the structural reasons behind the lower effectiveness of monetary policy shocks during uncertain times. To do so I adopt the lens of the workhorse New Keynesian model. In particular, I propose a simple state-conditional Minimum Distance estimation strategy of a DSGE model, which I apply to the Altig, Christiano, Eichenbaum and Lindè's (ACEL, 2011) model. The estimator matches as closely as possible the regime-dependent responses coming from an unrestricted Threshold VAR model with the corresponding model-based responses. This approach may capture possibly unmodelled mechanisms through regime-specific estimates of structural parameters. I find the ACEL model to be remarkably able to match the VAR impulse responses, particularly in tranquil times. This performance is driven by very different estimated values for some key-structural parameters in the two states. A higher slope of the new-Keynesian Phillips curve, a higher cost of the variation in capital utilization, and a lower degree of habit formation in consumption are shown to be behind the model ability to predict the lower real effects of monetary policy shocks in periods of high uncertainty.
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Costa, António Pedro Cardoso. "How the major capital markets interact in the world: a VAR approach." Master's thesis, 2011. http://hdl.handle.net/10071/4890.
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Durante as últimas décadas, a análise de dados financeiros, tais como, os preços das acções e os seus respectivos retornos, tem sido alvo de muito estudo por parte dos investigadores. Existe uma variedade de métodos que têm sido propostos e implementados com o objectivo de prever essas variáveis e também de estudar as relações interacções que têm entre si.
Esta tese tem como principal objectivo analisar a interacção entre os seguintes sete índices: o PSI20 (Portugal), CAC40 (França), IBEX35 (Espanha), Nikkei225 (Japão), DAX (Alemanha), NASDAQ (Estados Unidos da América), e FOOTSIE100 (Reino Unido).
A análise efectuada teve como suporte uma base de dados com observações diárias entre os anos 2000 e 2010, e a metodologia econométrica incluí os testes: Augmented Dickey-Fuller, KPSS, causalidade de Granger e os modelos VAR.For many years, financial data analysis, such as stock prices and returns, has been receiving a lot of attention from researchers. A variety of methods has been proposed and implemented in order to forecast these variables and also to study the relation and interaction between them. The main goal of this thesis is to analyze the interaction between the following seven indexes the PSI20 (Portugal), CAC40 (France), IBEX35 (Spain), NIKKEI225 (Japan), DAX (Germany), NASDAQ (United States of America), and FOOTSIE100 (United Kingdom). The analysis was based on a database with daily observations between 2000 and 2010, and the econometric methodology includes: Augmented Dickey-Fuller, KPSS, Granger causality test and VAR models.
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Pépin, Yan. "L'Émerillon, ou, le Val des regrets : un jeu vidéo utilisé comme moyen d'expression." Mémoire, 2006. http://www.archipel.uqam.ca/3035/1/M9315.pdf.
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Ce mémoire de maîtrise en multimédia relate les principales étapes de la production de L'Émerillon ou le Val des Regrets, un conte interactif en trois dimensions rendu en temps réel et distribué sur cédérom. Avec ce projet, nous avions comme principaux objectifs d'étudier la portée communicationnelle et expressive des jeux vidéo, de même que de développer une méthodologie de travail pour la réalisation d'environnements virtuels interactifs avec des moyens restreints. L'aventure de L'Émerillon ou le Val des Regrets se déroule dans la forêt de Brocéliande en Bretagne armoricaine, environ cent ans après la mort du légendaire roi Arthur. Dans cet univers mythique, le joueur est appelé à incarner un vieux chevalier à la recherche d'un oiseau (l'émerillon) qui lui fut donné par son amante, mais qui s'est mystérieusement échappé. Partant en quête, le vieil homme rencontre, dans le Val des Regrets, plusieurs apparitions de lui-même à divers stades de sa vie qu'il doit confronter pour enfin retrouver la sérénité. Ce n'est qu'au bout d'un long voyage intérieur qu'il parviendra enfin à Ynis Wittrin, l'Île de Verre, où il retrouvera son amante, mais où, entraîné par l'émerillon, il accèdera aussi à un autre niveau de conscience qui l'amènera à partir de nouveau à l'aventure. Le jeu forme une boucle. de façon à ce que la quête du chevalier ne se termine jamais, pour illustrer le caractère perpétuel de la recherche du bonheur et de la découverte de soi. Pour progresser dans le jeu, le joueur doit résoudre des énigmes faisant appel à sa coordination et ses réflexes, son sens logique, et sa capacité à faire un choix rapidement. L'objectif final du jeu est de faire réfléchir le joueur sur le sens de sa propre vie à travers les actions qu' il a entreprises dans la peau du vieux chevalier. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : Jeux, Vidéo, Légendes arthuriennes, Moyen-Âge, Conte interactif, Interactivité, Bretagne, Brocéliande.
Books on the topic "Interacted VAR"
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Hildebrand, W. J. Theorie van theatrale interactie. Amsterdam: Thela Thesis, 1999.
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Het thema centraal: Theorie en praktijk van themagecentreerde interactie. Soest: Nelissen, 2004.
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Mechtild, Claessens, ed. De anderen en ik: Het belang van sociale intelligentie. Amsterdam [etc.]: De Arbeiderspers, 2011.
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Mevissen, J. W. M. Interactie met beleid?: Een verkenning van het arbeidsmarktgedrag van overheid en ondernemingen. Amsterdam: Swets & Zeitlinger, 1992.
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Gastelaars, R. E. van Engelsdorp. De nieuwe stad: Stedelijke centra als brandpunten van interactie. Rotterdam: NAi Uitgevers, 2006.
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Sluyzer, Betty (Elisabeth Maria), 1953-, Verburg, Marja (M.E.), and Gerritsen Paula 1956-, eds. Mijn eerste Van Dale Interactief woordenboek: Animaties en spelletjes. Utrecht: Van Dale Lexicografie, 2008.
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R. E. van Engelsdorp Gastelaars. De nieuwe stad: Stedelijke centra als brandpunten van interactie. Rotterdam: NAi Uitgevers, 2006.
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Mulder, Arjen. Van beeld naar interactie: Betekenis en agency in de kunsten. Rotterdam: V2_Publishing/NAi Uitgevers, 2010.
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1956-, Gerritsen Paula, ed. My First English Van Dale interactief woordenboek: Versjes en animaties. Utrecht: Van Dale, 2009.
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Wal, Harmen van de. Privacy scripting: De impact van architectuur op sociale interactie in woongebouwen. Bussum: Uitgeverij Thoth, 2015.
Find full textBook chapters on the topic "Interacted VAR"
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Remmerswaal, Jan. "Themagecentreerde interactie." In Begeleiden van groepen, 331–39. Houten: Bohn Stafleu van Loghum, 2015. http://dx.doi.org/10.1007/978-90-368-0725-8_34.
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Strik, Anneke, and Jacqueline Schoemaker. "Begeleiden van onderlinge interacties." In Interactievaardigheden, 239–89. Houten: Bohn Stafleu van Loghum, 2018. http://dx.doi.org/10.1007/978-90-368-2099-8_6.
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Vansteenwegen, Alfons. "Veranderen van de interactie." In Helpen bij partnerrelatieproblemen, 158–96. Houten: Bohn Stafleu van Loghum, 2005. http://dx.doi.org/10.1007/978-90-313-6406-0_10.
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Willemse, Joop. "De interpunctie van de interactie." In Anders kijken, 109–32. Houten: Bohn Stafleu van Loghum, 2015. http://dx.doi.org/10.1007/978-90-368-0844-6_6.
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Willemse, Joop. "De interpunctie van de interactie." In Anders kijken, 133–61. Houten: Bohn Stafleu van Loghum, 2012. http://dx.doi.org/10.1007/978-90-313-9213-1_6.
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van der Gaag, M., and J. van der Plas. "Angst: de interactie van verschillende leerniveaus." In Doelgericht begeleiden in de psychiatrie, 109–13. Houten: Bohn Stafleu van Loghum, 2016. http://dx.doi.org/10.1007/978-90-368-1570-3_13.
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Peeters, Maria, Pascale Peters, and Laura Den Dulk. "De interactie tussen werk en privé." In De psychologie van arbeid en gezondheid, 289–307. Houten: Bohn Stafleu van Loghum, 2020. http://dx.doi.org/10.1007/978-90-368-2495-8_15.
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Peters-Scheffer, Nienke, Hetty Joustra, and Petra Warreyn. "Bevorderen van ontwikkeling door stimuleren van interactie en aanleren van vaardigheden." In Autisme bij kinderen, 187–207. Houten: Bohn Stafleu van Loghum, 2021. http://dx.doi.org/10.1007/978-90-368-2665-5_13.
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Schuur, Geuk. "Zelfcontrole: hanteren van agressie in de interactie." In Omgaan met agressie, 123–44. Houten: Bohn Stafleu van Loghum, 2014. http://dx.doi.org/10.1007/978-90-368-0691-6_6.
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Schuur, Geuk. "6 Zelfcontrole: hanteren van agressie in de interactie." In Omgaan met agressie, 159–86. Houten: Bohn Stafleu van Loghum, 2009. http://dx.doi.org/10.1007/978-90-313-6962-1_6.
Full textConference papers on the topic "Interacted VAR"
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Devi, D. Muruga Radha, V. Maheswari, and P. Thambidurai. "Similarity search in Recent Biased time series databases using Vari-DWT and Polar wavelets." In 2010 International Conference on Emerging Trends in Robotics and Communication Technologies (INTERACT 2010). IEEE, 2010. http://dx.doi.org/10.1109/interact.2010.5706187.
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Sun, Yongbin, Alexandre Armengol-Urpi, Sai Nithin Reddy Kantareddy, Joshua Siegel, and Sanjay Sarma. "MagicHand: Interact with IoT Devices in Augmented Reality Environment." In 2019 IEEE Conference on Virtual Reality and 3D User Interfaces (VR). IEEE, 2019. http://dx.doi.org/10.1109/vr.2019.8798053.
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Andrieux, A., M. H. Charon, G. Hudry-Clergeon, and G. Marguerie. "FIBRINOGEN SEQUENCES INTERACTING WITH PLATELET GPIIbIIIa." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643519.
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Fibrinogen (Fg), fibronectin (Fn) and von Willebrand factor (vWF), interact with GPIIbllla on AD? stimulated platelets, and a common mechanism has been postulated for the binding of these adhesive proteins. Fg, Fn and vWF contain the tripeptide Arg-Gly-Asp and synthetic analogues to this sequence inhibit their interaction with platelet and their concomitant adhesive reactions. On the other hand, sequences corresponding to the Fg γ chain inhibit the binding of Fg, Fn and vWF to platelet and may also represent a potential recognition site. This raises the possibility that the γ chain sequence and Arg-Gly-Asp interact with the same site or represent primary and secondary sites for the Fg molecule. Within this context, the capacity of these sequences to interact with GPIIbllla and to block fibrinogen binding were compared. The smallest γ chain sequence that was active in inhibiting this reaction was the hexamer Lys-Gln-Ala-Gly-Asp-Val corresponding to the last six amino acid residues at the C-terminus of the γ chain. In parallel, peptides with the structure Arg-Gly-Asp-X were synthesized and tested in vitro. The activity of these peptides was dependent upon the hydrophobicity of the amino acid residue at position X. Arg-GLy-Asp-Phe corresponding to the sequence at position 95-98 in the Fg Aα chain was 5 to 10 times more active than Arg-GLy-Asp-Ser, present at position 572-575 in the Aα chain, and was 10 to 20 times more active than the γ chain hexamer. Both the Aα chain and γ chain sequences however, inhibited Fg binding by greater than 90%. When the γ chain sequence and the Arg-Gly-Asp-X sequence were coupled to Sepharose, GPIIbIIIa interacted with these sequences and was eluted from each column by either of the peptides. Finally direct binding experiments indicated that Arg-Gly-Asp-X and γ chain sequences are competitive antagonists. These results suggest that both sequences interact with the same site on GPIIbIIIa and comparison of the hydrophilicity of these peptides suggests that the binding domain on GPIIbIIIa exhibits hydrophobic properties.
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Nahún Quintero Milián, Héctor, Nora Argelia Aguilera, Pablo Guillermo Ramírez Flores, and Samira Hosseini. "Synergy of digital art, architecture and design using video-mapping in a combined classroom." In The 5th International Conference on Virtual and Augmented Reality in Education. CAL-TEK srl, 2019. http://dx.doi.org/10.46354/i3m.2019.vare.001.
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"Technological advances within educational domains permit new teaching systems to emerge. Video-mapping is a technique that involves projecting images on threedimensional surfaces through motion effects. In the case of architectural projects, there are very few uses of videomapping that focus on urban planning and even fewer when the mapping is interactive. However, it is crucial to scale new ways of interpreting design using technologies such as video-mapping. In this research work, the themes of virtual environments, spatial representation, and basic design are combined with video-mapping. Students from the Digital Art and Architecture and the Industrial Design programs worked together in this effort, creating an architectural model made with 3D impressions; the users interacted and selected from the options of colors and textures available for the model city, generating different presentations according to the changes in the settings of the video-mapping software. Thus, this project opened the doors to welcome digital artists into the world of architecture and urbanism."
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DU, YI-MING, RUI DING, YI-LIN ZHANG, TING ZHANG, and TAO ZHOU. "RESEARCH ON THE RELATIONSHIP BETWEEN INVESTOR SENTIMENT AND STOCK PRICE." In 2021 International Conference on Management, Economics, Business and Information Technology. Destech Publications, Inc., 2021. http://dx.doi.org/10.12783/dtem/mebit2021/35642.
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As one of the main contents of behavioral finance, investor sentiment has become a research hotspot in recent years. This paper takes the CSI300 index of China as the observation object, selects five emotional monthly time series data including lag one period from 2016 to 2020. The method of principal component analysis will be used to reduce the dimension of 10 groups of data. After eliminating the macroeconomic factors, the dimension reduction results are analyzed by the second principal component analysis to obtain the comprehensive index of emotion. Furthermore, a Vector Auto Regressive model (VAR) is established to investigate the relationship between ISIO and CSI300 of the stock market. The results show that investor sentiment and stock price interact with each other, but only in the short term. With more and more sufficient market information known, the effect is becoming insignificant.
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Cattaneo, M., A. Lecchi, L. J. McGregor, M. A. Randi, M. P. Mannucci, and A. Bianchi. "CHARACTERIZATION OF PLATELETS OF A PATIENT WITH A SELECTIVE DEFECT IN ADP-INDUCED AGGREGATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643638.
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We studied a patient (V.R.) with a mild hemorrhagic disorder and prolonged bleeding time. Platelet aggregation induced by ADP (2-50 uM) in V.R.’s citrated PRP or washed platelets (WP) was greatly impaired; in contrast ADP (0.1-1 uM) induced normal platelet shape change of V.R. platelets. Collagen-induced aggregation was absent at low (1-2 ug/ml) but not at high concentration (10 ug/ml). Thrombin at high (1 U/ml) but not at low concentration (0.05 U/ml) induced normal aggregation of V.R.’s WP. Apyrase added to normal PRP or WP caused defective platelet aggregation similar to that observed for V.R.’s platelets. Chymotrypsin-treated WP from V.R. and from a normal control aggregated to the same extent upon addition of fibrinogen. CIE and two-dimensional non-reduced/reduced SDS-PAGE showed no abnormalities of platelet membrane glycoproteins. 125I-fibrinogen (125I-Fg) binding induced by ADP (10 uM) to V.R.’s platelets was absent. Thrombin(0.05-1 U/ml)-induced binding of 125I-Fg to was 20-30% of normal. Chymotrypsin-treated V.R’s platelets bound normal amounts of 125I-Fg. Addition of apyrase to thrombin—stimulated normal platelets lowered 125I-Fg binding to that of thrombin-stimulated V.R.’s platelets. However, 125I-Fg binding to thrombin—stimulated V.R.’s platelets was not affected by apyrase. Unstimulated V.R.’s WP bound the 125I-labeled monoclonal antibody 7E3 (anti Ilb/IIIa) at the same rate and to the same extent as normal WP. Thrombin (1 U/ml) increased the rate of binding of 125I-7E3 to both V.R.’s and control platelets. In contrast, ADP (10 uM) increased the rate of 125I-7E3 binding to control but not to V.R.’s platelets. C-ADP binding to V.R.’s platelets was normal. Therefore, ADP normally interacts with V.R.’s platelets, but does not induce fibrinogen receptors exposure. Selective defects in the ADP pathway of platelet aggregation have not been previously described.
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Charon, M. H., L. Tranqui, A. Andrieux, G. Hudry-Clergeon, and G. Marguerie. "FIBRINOGEN BINDING TO ENDOTHELIAL CELLS AND INTERFERING PEPTIDES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644735.
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Fibrinogen interacts with platelets and endothelial cells via specific binding sites. While the platelet fibrinogen receptor has been identified and was found to be associated with GPIIb-IIIa, the binding site on endothelial cells has not been characterized yet. The platelet GPIIb-IIIa belongs to the newly identified cytoadhesin family which includes immunologicaly related receptors interacting with RGD containing proteins. A cytoadhesin has recently been described on endothelial cells and the possibility that fibrinogen might interact with this glycoprotein was examined. Peptides corresponding to γ and α chains sequences were synthesized and their capacity to inhibit fibrinogen binding to endothelial cells and platelets were compared. Analogues of the γ chain from His 400 to Val 411 produced an inhibition similar to that observed for fibrinogen platelet interaction, suggesting that the structure function relationship of γ peptides is identical in both systems. In contrast synthetic analogues corresponding to the a chain and including RGD yielded slightly different results. While RGD alone was inactive on platelet, this tripeptide was active on endothelial cells. RGDS and RGDF corresponding to α 572-575 and α 95-98 partially or fully inhibited fibrinogen binding to endothelial cells but the structure activity relationship was different when compared to that observed for platelets. Addition of the N and C sequences adjacent to RGDS reduced the activity of this peptide whereas the activity of RGDF analogues was not modified by addition of N and C-sequences. In contrast platelet fibrinogen binding decreased with these RGDF analogues. These results suggest that fibrinogen endothelial cell binding is mediated by an RGD adhesion receptor with subtle differences in the recognition selectivity of the ligand, which is controled by the surrounding sequence.
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Weng, Jian-Gang, Chang-Lin Tien, and Arun Majumdar. "Intermolecular and Surface Forces and Their Role in Nanoscale Liquid Transport and Phase Change." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/htd-24196.
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Abstract When liquid molecules interact in a highly confined region, their bulk characteristics are often overshadowed by near-field intermolecular and surface forces. These include van der Waals, electrostatic, structural, and surface tension forces. This paper will present two examples of how thermodynamic models and Molecular Dynamic simulation can provide insight into nanoscale liquid transport and phase change: liquid film stability and the curvature effect on surface tension of droplets and bubbles. Both examples have major ramifications on problems such as nucleation, condensation, boiling, biological transport etc.
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Anureka, R., and K. Srinivasan. "The Role of Castellations on Pipe Jet Noise." In ASME 2018 Noise Control and Acoustics Division Session presented at INTERNOISE 2018. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/ncad2018-6129.
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This paper explores jet noise control using castellations at the exit of pipe-jets. Far-field acoustic measurements and schlieren visualizations are performed for two configurations of castellations; namely, two and four counts. The results are compared with that of pipe-jet without castellations. The nozzle pressure ratio range of the study is 1.5 to 4.5. With each configuration, the position and strength of vortices vary causing it to interact in different manners. For pipe with two castellations, the screech is amplified and the overall sound pressure level is higher than the reference jet in most of the nozzle pressure ratios under study. For pipe with four castellations, there is no noise variation in the azimuthal direction, and screech is eliminated at all nozzle pressure ratios.
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Bal, Harun, Mehmet Demiral, and Filiz Yetiz. "Exchange Rate Pass-Through to Domestic Prices: Evidence from OECD Countries." In International Conference on Eurasian Economies. Eurasian Economists Association, 2017. http://dx.doi.org/10.36880/c08.01951.
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There is an immense literature on the effects of exchange rate changes on macroeconomic indicators, specifically on the trade balance, growth, inflation, and overall productivity in open economies. One of the main attempts in the related literature is about ascertaining whether the exchange rate fluctuations alter domestic prices. This possible mechanism is called as the pass-through effect which is getting more important since the argument that exchange rate adjustment is a part of the solution for global rebalancing is empirically well-supported. Starting from this claim, this study purposes to explore whether there is an exchange rate pass-through effect in 19 high-income OECD countries over the period 1990-2015. To this end, using a panel data set of consumer price index, producer price index proxied by wholesale price index, the nominal effective exchange rates, and industrial production presented by the value-added share of industry sectors in gross domestic product, structural vector autoregressive (VAR) and autoregressive distributed lag (ARDL) models are estimated in an unbalanced panel data analysis procedure. Results reveal that exchange rate pass-through effects on the domestic prices are significant but not that strong in both the short-run and the long-run. Expectedly, the pass-through effects tend to diminish over time. The study concludes that policy-makers need to consider policy actions accompanying the exchange rate changes to ensure domestic price stability which consequently interacts with many macroeconomic indicators.
Reports on the topic "Interacted VAR"
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Peters, R., J. Visser, and L. Molendijk. Literatuurstudie naar interacties plantparasitaire aaltjes met plantpathogene bodemschimmels : beschrijving van interacties en mechanismen en hun betekenis voor de akkerbouw en bollenteelt. Wageningen: Stichting Wageningen Research, Wageningen Plant Research, Business unit Open Teelten, 2022. http://dx.doi.org/10.18174/576264.
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Messelink, Gerben, Yvonne van Vugt, Joop Woelke, Laura Català Senent, and Ada Leman. Spintbestrijding met roofmijten in komkommer : Effecten van luchtvochtigheid en onderlinge interacties tussen roofmijtsoorten. Bleiswijk: Stichting Wageningen Research, Wageningen Plant Research, Business unit Glastuinbouw, 2022. http://dx.doi.org/10.18174/574699.
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liu, cong, xing wang, rao chen, and jie zhang. Meta-analyses of the Effects of Virtual Reality Training on Balance, Gross Motor Function and Daily Living Ability in Children with Cerebral Palsy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0137.
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Review question / Objective: Cerebral palsy (CP) is a non-progressive, persistent syndrome occurring in the brain of the fetus or infant[1]. The prevalence of CP is 0.2% worldwide, and the prevalence can increase to 20-30 times in preterm or low birth weight newborns. There are about 6 million children with CP in China, and the number is increasing at a rate of 45,000 per year. Virtual reality (VR) refers to a virtual environment that is generated by a computer and can be interacted with.VR can mobilize the visual, auditory, tactile and kinesthetic organs of CP, so that they can actively participate in the rehabilitation exercise. Information sources: Two researchers searched 5 databases, including Pubmed (N=82), Embase (N=191), The Cochrane Library (N=147), Web of Science (N=359) and CNKI (N=11).
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Wisniewski, Michael, Samir Droby, John Norelli, Dov Prusky, and Vera Hershkovitz. Genetic and transcriptomic analysis of postharvest decay resistance in Malus sieversii and the identification of pathogenicity effectors in Penicillium expansum. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597928.bard.
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Use of Lqh2 mutants (produced at TAU) and rNav1.2a mutants (produced at the US side) for identifying receptor site-3: Based on the fact that binding of scorpion alpha-toxins is voltage-dependent, which suggests toxin binding at the mobile voltage-sensing region, we analyzed which of the toxin bioactive domains (Core-domain or NC-domain) interacts with the DIV Gating-module of rNav1.2a. This analysis was based on the assumption that the dissociation of toxin mutants upon depolarization would vary from that of the unmodified toxin should the substitutions affect a site of interaction with the channel Gating-module. Using a series of toxin mutants (mutations at both domains) and two channel mutants that were shown to reduce the sensitivity to scorpion alpha-toxins, and by comparison of depolarization-driven dissociation of Lqh2 derivatives off their binding site at rNav1.2a mutant channels we found that the toxin Core-domain interacts with the Gating-module of DIV. Details of the experiments and results appear in Guret al (2011). Mapping receptor site 3 at Nav1.2a by extensive channel mutagenesis (Seattle): Since previous studies with photoaffinity labeling and antibody mapping implicated domains I and IV in scorpion alpha-toxin binding, Nav1.2 channel mutants containing substitutions at these extracellular regions were expressed and tested for receptor function by whole-cell voltage clamp. Of a large number of channel mutants, T1560A, F1610A, and E1613A in domain IV had ~5.9-, ~10.7-, and ~3.9-fold lower affinities for the scorpion toxin Lqh2, respectively, and mutant E1613R had 73-fold lower affinity. Toxin dissociation was accelerated by depolarization for both wild-type and mutants, and the rates of dissociation were also increased by mutations T1560A, F1610A and E1613A. In contrast, association rates for these three mutant channels at negative membrane potentials were not significantly changed and were not voltage-dependent. These results indicated that Thr1560 in the S1-S2 loop, Phe1610 in the S3 segment, and Glu1613 in the S3-S4 loop in domain IV participate in toxin binding. T393A in the SS2-S6 loop in domain I also showed a ~3.4-fold lower affinity for Lqh2, indicating that this extracellular loop may form a secondary component of the toxin binding site. Analysis with the Rosetta-Membrane algorithm revealed a three-dimensional model of Lqh2 binding to the voltage sensor in a resting state. In this model, amino acid residues in an extracellular cleft formed by the S1-S2 and S3-S4 loops in domain IV that are important for toxin binding interact with amino acid residues on two faces of the wedge-shaped Lqh2 molecule that are important for toxin action. The conserved gating charges in the S4 transmembrane segment are in an inward position and likely form ion pairs with negatively charged amino acid residues in the S2 and S3 segments (Wang et al 2011; Gurevitz 2012; Gurevitzet al 2013).
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Baluk, Nadia, Natalia Basij, Larysa Buk, and Olha Vovchanska. VR/AR-TECHNOLOGIES – NEW CONTENT OF THE NEW MEDIA. Ivan Franko National University of Lviv, February 2021. http://dx.doi.org/10.30970/vjo.2021.49.11074.
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The article analyzes the peculiarities of the media content shaping and transformation in the convergent dimension of cross-media, taking into account the possibilities of augmented reality. With the help of the principles of objectivity, complexity and reliability in scientific research, a number of general scientific and special methods are used: method of analysis, synthesis, generalization, method of monitoring, observation, problem-thematic, typological and discursive methods. According to the form of information presentation, such types of media content as visual, audio, verbal and combined are defined and characterized. The most important in journalism is verbal content, it is the one that carries the main information load. The dynamic development of converged media leads to the dominance of image and video content; the likelihood of increasing the secondary content of the text increases. Given the market situation, the effective information product is a combined content that combines text with images, spreadsheets with video, animation with infographics, etc. Increasing number of new media are using applications and website platforms to interact with recipients. To proceed, the peculiarities of the new content of new media with the involvement of augmented reality are determined. Examples of successful interactive communication between recipients, the leading news agencies and commercial structures are provided. The conditions for effective use of VR / AR-technologies in the media content of new media, the involvement of viewers in changing stories with augmented reality are determined. The so-called immersive effect with the use of VR / AR-technologies involves complete immersion, immersion of the interested audience in the essence of the event being relayed. This interaction can be achieved through different types of VR video interactivity. One of the most important results of using VR content is the spatio-temporal and emotional immersion of viewers in the plot. The recipient turns from an external observer into an internal one; but his constant participation requires that the user preferences are taken into account. Factors such as satisfaction, positive reinforcement, empathy, and value influence the choice of VR / AR content by viewers.
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Stern, David, and Gadi Schuster. Manipulation of Gene Expression in the Chloroplast. United States Department of Agriculture, September 2000. http://dx.doi.org/10.32747/2000.7575289.bard.
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The steady-state level of a given mRNA is determined by its rates of transcription and degradation. The stabilities of chloroplast mRNAs vary during plant development, in part regulating gene expression. Furthermore, the fitness of the organelle depends on its ability to destroy non-functional transcripts. In addition, there is a resurgent interest by the biotechnology community in chloroplast transformation due to the public concerns over pollen transmission of introduced traits or foreign proteins. Therefore, studies into basic gene expression mechanisms in the chloroplast will open the door to take advantage of these opportunities. This project was aimed at gaining mechanistic insights into mRNA processing and degradation in the chloroplast and to engineer transcripts of varying stability in Chlamydomonas reinhardtii cells. This research uncovered new and important information on chloroplast mRNA stability, processing, degradation and translation. In particular, the processing of the 3' untranslated regions of chloroplast mRNAs was shown to be important determinants in translation. The endonucleolytic site in the 3' untranslated region was characterized by site directed mutagensis. RNA polyadenylation has been characterized in the chloroplast of Chlamydomonas reinhardtii and chloroplast transformants carrying polyadenylated sequences were constructed and analyzed. Data obtained to date suggest that chloroplasts have gene regulatory mechanisms which are uniquely adapted to their post-endosymbiotic environment, including those that regulate RNA stability. An exciting point has been reached, because molecular genetic studies have defined critical RNA-protein interactions that participate in these processes. However, much remains to be learned about these multiple pathways, how they interact with each other, and how many nuclear genes are consecrated to overseeing them. Chlamydomonas is an ideal model system to extend our understanding of these areas, given its ease of manipulation and the existing knowledge base, some of which we have generated.
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Gurevitz, Michael, William A. Catterall, and Dalia Gordon. Learning from Nature How to Design Anti-insect Selective Pesticides - Clarification of the Interacting Face between Insecticidal Toxins and their Na-channel Receptors. United States Department of Agriculture, January 2010. http://dx.doi.org/10.32747/2010.7697101.bard.
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Structural details on the interacting faces of toxins and sodium channels (Navs), and particularly identification of elements that confer specificity for insects, are difficult to approach and require suitable experimental systems. Therefore, natural toxins capable of differential recognition of insect and mammalian Navs are valuable leads for design of selective compounds in insect control. We have characterized several scorpion toxins that vary in preference for insect and mammalian Navs, and identified residues important for their action. However, despite many efforts worldwide, only little is known about the receptor sites of these toxins, and particularly on differences between these sites on insect and mammalian Navs. Another problem arises from the massive overuse of chemical insecticides, which increases resistance buildup among various insect pests. A possible solution to this problem is to combine different insecticidal compounds, especially those that provide synergic effects. Our recent finding that combinations of insecticidal receptor site-3 toxins (sea anemone and scorpion alpha) with scorpion beta toxins or their truncated derivatives are synergic in toxicity to insects is therefore timely and strongly supports this approach. Our ability to produce toxins and various Navs in recombinant forms, enable thorough analysis and structural manipulations of both toxins and receptors. On this basis we propose to (1) restrict by mutagenesis the activity of insecticidal scorpion -toxins and sea anemone toxins to insects, and clarify the molecular basis of their synergic toxicity with antiinsect selective -toxins; (2) identify Nav elements that interact with scorpion alpha and sea anemone toxins and those that determine toxin selectivity to insects; (3) determine toxin-channel pairwise side-chain interactions by thermodynamic mutant cycle analysis using our large collection of mutant -toxins and Nav mutants identified in aim 2; (4) clarify the mode of interaction of truncated -toxins with insect Navs, and elucidate how they enhance the activity of insecticidal site-3 toxins. This research may lead to rational design of novel anti-insect peptidomimetics with minimal impact on human health and the environment, and will establish the grounds for a new strategy in insect pest control, whereby a combination of allosterically interacting compounds increase insecticidal action and reduce risks of resistance buildup.
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McGuire, Mark A., Amichai Arieli, Israel Bruckental, and Dale E. Bauman. Increasing Mammary Protein Synthesis through Endocrine and Nutritional Signals. United States Department of Agriculture, January 2001. http://dx.doi.org/10.32747/2001.7574338.bard.
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Objectives To determine endocrine factors that regulate the partitioning of amino acids by the mammary gland. To evaluate dietary flow and supply of energy and amino acids and their effects on milk protein synthesis and endocrine status. To use primary cultures of cow mammary epithelial cells to examine the role of specific factors on the rates and pattern of milk protein synthesis. Milk protein is an increasingly valuable component of milk but little is known regarding the specific hormonal and nutritional factors controlling milk protein synthesis. The research conducted for this project has determined that milk protein synthesis has the potential to be enhanced much greater than previously believed. Increases of over 25% in milk protein percent and yield were detected in studies utilizing abomasal infusion of casein and a hyperinsulinemic-euglycemic clamp. Thus, it appears that insulin, either directly or indirectly, can elicit a substantial increase in milk protein synthesis if additional amino acids are supplied. For additional amino acids, casein provided the best response even though substantial decreases in branched chain amino acids occur when the insulin clamp is utilized. Branched chain amino acids alone are incapable of supporting the enhanced milk protein output. The mammary gland can vary both blood flow and extraction efficiency of amino acids to support protein synthesis. A mammary culture system was used to demonstrate specific endocrine effects on milk protein synthesis. Insulin-like growth factor-I when substituted for insulin was able to enhance casein and a-lactalbumin mRNA. This suggests that insulin is a indirect regulator of milk protein synthesis working through the IGF system to control mammary production of casein and a-lactalbumin. Principal component analysis determined that carbohydrate had the greatest effect on milk protein yield with protein supply only having minor effects. Work in cattle determined that the site of digestion of starch did not affect milk composition alone but the degradability of starch and protein in the rumen can interact to alter milk yield. Cows fed diets with a high degree of rumen undegradability failed to specifically enhance milk protein but produced greater milk yield with similar composition. The mammary gland has an amazing ability to produce protein of great value. Research conducted here has demonstrated the unprecedented potential of the metabolic machinery in the mammary gland. Insulin, probably signaling the mammary gland through the IGF system is a key regulator that must be combined with adequate nutrition in order for maximum response.
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Gurevitz, Michael, William A. Catterall, and Dalia Gordon. face of interaction of anti-insect selective toxins with receptor site-3 on voltage-gated sodium channels as a platform for design of novel selective insecticides. United States Department of Agriculture, December 2013. http://dx.doi.org/10.32747/2013.7699857.bard.
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Voltage-gated sodium channels (Navs) play a pivotal role in excitability and are a prime target of insecticides like pyrethroids. Yet, these insecticides are non-specific due to conservation of Navs in animals, raising risks to the environment and humans. Moreover, insecticide overuse leads to resistance buildup among insect pests, which increases misuse and risks. This sad reality demands novel, more selective, insect killers whose alternative use would avoid or reduce this pressure. As highly selective insect toxins exist in venomous animals, why not exploit this gift of nature and harness them in insect pest control? Many of these peptide toxins target Navs, and since their direct use via transformed crop plants or mediator microorganisms is problematic in public opinion, we focus on the elucidation of their receptor binding sites with the incentive of raising knowledge for design of toxin peptide mimetics. This approach is preferred nowadays by agro-industries in terms of future production expenses and public concern. However, characterization of a non-continuous epitope, that is the channel receptor binding site for such toxins, requires a suitable experimental system. We have established such a system within more than a decade and reached the stage where we employ a number of different insect-selective toxins for the identification of their receptor sites on Navs. Among these toxins we wish to focus on those that bind at receptor site-3 and inhibit Nav inactivation because: (1) We established efficient experimental systems for production and manipulation of site-3 toxins from scorpions and sea anemones. These peptides vary in size and structure but compete for site-3 on insect Navs. Moreover, these toxins exhibit synergism with pyrethroids and with other channel ligands; (2) We determined their bioactive surfaces towards insect and mammalian receptors (see list of publications); (3) We found that despite the similar mode of action on channel inactivation, the preference of the toxins for insect and mammalian channel subtypes varies greatly, which can direct us to structural features in the basis of selectivity; (4) We have identified by channel loop swapping and point mutagenesis extracellular segments of the Navinvolved with receptor site-3. On this basis and using channel scanning mutagenesis, neurotoxin binding, electrophysiological analyses, and structural data we offer: (i) To identify the residues that form receptor site-3 at insect and mammalian Navs; (ii) To identify by comparative analysis differences at site-3 that dictate selectivity toward various Navs; (iii) To exploit the known toxin structures and bioactive surfaces for modeling their docking at the insect and mammalian channel receptors. The results of this study will enable rational design of novel anti-insect peptide mimetics with minimized risks to human health and to the environment. We anticipate that the release of receptor site-3 molecular details would initiate a worldwide effort to design peptide mimetics for that site. This will establish new strategies in insect pest control using alternative insecticides and the combined use of compounds that interact allosterically leading to increased efficiency and reduced risks to humans or resistance buildup among insect pests.
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Borch, Thomas, Yitzhak Hadar, and Tamara Polubesova. Environmental fate of antiepileptic drugs and their metabolites: Biodegradation, complexation, and photodegradation. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597927.bard.
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Many pharmaceutical compounds are active at very low doses, and a portion of them regularly enters municipal sewage systems and wastewater-treatment plants following use, where they often do not fully degrade. Two such compounds, CBZ and LTG, have been detected in wastewater effluents, surface waters, drinking water, and irrigation water, where they pose a risk to the environment and the food supply. These compounds are expected to interact with organic matter in the environment, but little is known about the effect of such interactions on their environmental fate and transport. The original objectives of our research, as defined in the approved proposal, were to: Determine the rates, mechanisms and products of photodegradation of LTG, CBZ and selected metabolites in waters exposed to near UV light, and the influence of DOM type and binding processes on photodegradation. Determine the potential and pathways for biodegradation of LTG, CBZ and selected metabolites using a white rot fungus (Pleurotusostreatus) and ADP, and reveal the effect of DOM complexation on these processes. Reveal the major mechanisms of binding of LTG, CBZ and selected metabolites to DOM and soil in the presence of DOM, and evaluate the effect of this binding on their photodegradation and/or biodegradation. We determined that LTG undergoes relatively slow photodegradation when exposed to UV light, and that pH affects each of LTG’s ability to absorb UV light, the efficiency of the resulting reaction, and the identities of LTG’sphotoproducts (t½ = 230 to 500 h during summer at latitude 40 °N). We observed that LTG’sphotodegradation is enhanced in the presence of DOM, and hypothesized that LTG undergoes direct reactions with DOM components through nucleophilic substitution reactions. In combination, these data suggest that LTG’s fate and transport in surface waters are controlled by environmental conditions that vary with time and location, potentially affecting the environment and irrigation waters. We determined that P. ostreatusgrows faster in a rich liquid medium (glucose peptone) than on a natural lignocellulosic substrate (cotton stalks) under SSF conditions, but that the overall CBZ removal rate was similar in both media. Different and more varied transformation products formed in the solid state culture, and we hypothesized that CBZ degradation would proceed further when P. ostreatusand the ᵉⁿᶻʸᵐᵃᵗⁱᶜ ᵖʳᵒᶠⁱˡᵉ ʷᵉʳᵉ ᵗᵘⁿᵉᵈ ᵗᵒ ˡⁱᵍⁿⁱⁿ ᵈᵉᵍʳᵃᵈᵃᵗⁱᵒⁿ. ᵂᵉ ᵒᵇˢᵉʳᵛᵉᵈ ¹⁴C⁻Cᴼ2 ʳᵉˡᵉᵃˢᵉ ʷʰᵉⁿ ¹⁴C⁻ᶜᵃʳᵇᵒⁿʸˡ⁻ labeled CBZ was used as the substrate in the solid state culture (17.4% of the initial radioactivity after 63 days of incubation), but could not conclude that mineralization had occurred. In comparison, we determined that LTG does not degrade in agricultural soils irrigated with treated wastewater, but that P. ostreatusremoves up to 70% of LTG in a glucose peptone medium. We detected various metabolites, including N-oxides and glycosides, but are still working to determine the degradation pathway. In combination, these data suggest that P. ostreatuscould be an innovative and effective tool for CBZ and LTG remediation in the environment and in wastewater used for irrigation. In batch experiments, we determined that the sorption of LTG, CBZ and selected metabolites to agricultural soils was governed mainly by SOM levels. In lysimeter experiments, we also observed LTG and CBZ accumulation in top soil layers enriched with organic matter. However, we detected CBZ and one of its metabolites in rain-fed wheat previously irrigated with treated wastewater, suggesting that their sorption was reversible, and indicating the potential for plant uptake and leaching. Finally, we used macroscale analyses (including adsorption/desorption trials and resin-based separations) with molecular- level characterization by FT-ICR MS to demonstrate the adsorptive fractionation of DOM from composted biosolids by mineral soil. This suggests that changes in soil and organic matter types will influence the extent of LTG and CBZ sorption to agricultural soils, as well as the potential for plant uptake and leaching.