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1

Lewin, D. I. "Intensity-modulated radiation therapy." Computing in Science & Engineering 4, no. 5 (September 2002): 8–9. http://dx.doi.org/10.1109/mcise.2002.1032423.

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2

Williams, P. C. "Intensity-Modulated Radiation Therapy." Physics in Medicine and Biology 46, no. 8 (July 18, 2001): 2267–68. http://dx.doi.org/10.1088/0031-9155/46/8/701.

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3

Purdy, James A. "Intensity-modulated radiation therapy." International Journal of Radiation Oncology*Biology*Physics 35, no. 4 (July 1996): 845–46. http://dx.doi.org/10.1016/0360-3016(96)00223-4.

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4

Goffman, Thomas E., and Eli Glatstein. "Intensity-Modulated Radiation Therapy." Radiation Research 158, no. 1 (July 2002): 115–17. http://dx.doi.org/10.1667/0033-7587(2002)158[0115:imrt]2.0.co;2.

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5

Murthy, Vedang, and Alan Horwich. "Intensity Modulated Radiation Therapy." European Journal of Cancer 40, no. 16 (November 2004): 2349–51. http://dx.doi.org/10.1016/j.ejca.2004.06.029.

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6

Lee, N. Y., and S. A. Terezakis. "Intensity-modulated radiation therapy." Journal of Surgical Oncology 97, no. 8 (2008): 691–96. http://dx.doi.org/10.1002/jso.21014.

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7

Esiashvili, Natia, Mary Koshy, and Jerome Landry. "Intensity-modulated radiation therapy." Current Problems in Cancer 28, no. 2 (March 2004): 47–84. http://dx.doi.org/10.1016/j.currproblcancer.2004.01.001.

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8

Reddya, U. Umamaheswara, and Panduranganath . "Comparison of Volumetric Modulated ARC Therapy (VMAT) to Conventional Intensity Modulated Radiation Therapy for Carcinoma Cervix." Indian Journal of Cancer Education and Research 5, no. 2 (2017): 113–25. http://dx.doi.org/10.21088/ijcer.2321.9815.5217.10.

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9

Rana, Suresh. "Intensity modulated radiation therapy versus volumetric intensity modulated arc therapy." Journal of Medical Radiation Sciences 60, no. 3 (August 22, 2013): 81–83. http://dx.doi.org/10.1002/jmrs.19.

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10

Xu, Tong, Polad M. Shikhaliev, Muthana Al-Ghazi, and Sabee Molloi. "Reshapable physical modulator for intensity modulated radiation therapy." Medical Physics 29, no. 10 (September 12, 2002): 2222–29. http://dx.doi.org/10.1118/1.1508109.

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11

Tang, G., M. Earl, S. Luan, C. Wang, S. Naqvi, and C. Yu. "TU-EE-A1-06: Comparison of Intensity-Modulated Radiation Therapy, Intensity-Modulated Arc Therapy and Arc-Modulated Radiation Therapy." Medical Physics 35, no. 6Part22 (June 2008): 2910. http://dx.doi.org/10.1118/1.2962610.

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12

Ulger, Sukran, Eren Cetin, Serap Catli, Hilal Sarac, Diclehan Kilic, and Huseyin Bora. "Intensity-Modulated Radiation Therapy Improves the Target Coverage Over 3-D Planning While Meeting Lung Tolerance Doses for All Patients With Malignant Pleural Mesothelioma." Technology in Cancer Research & Treatment 16, no. 3 (November 15, 2016): 332–38. http://dx.doi.org/10.1177/1533034616678110.

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Purpose: To investigate high conformality on target coverage and the ability on creating strict lung dose limitation of intensity-modulated radiation therapy in malignant pleural mesothelioma. Patients and Methods: Twenty-four radiation therapy plannings were evaluated and compared with dosimetric outcomes of conformal radiation therapy and intensity-modulated radiation therapy. Hemithoracal radiation therapy was performed on 12 patients with a fraction of 1.8 Gy to a total dose of 50.4 Gy. All organs at risk were contoured. Radiotherapy plannings were differed according to the technique; conformal radiation therapy was planned with conventionally combined photon–electron fields, and intensity-modulated radiation therapy was planned with 7 to 9 radiation beam angles optimized in inverse planning. Strict dose–volume constraints were applied. Results: Intensity-modulated radiation therapy was statistically superior in target coverage and dose homogeneity (intensity-modulated radiation therapy-planning target volume 95 mean 100%; 3-dimensional conformal radiation therapy-planning target volume 95 mean 71.29%, P = .0001; intensity-modulated radiation therapy-planning target volume 105 mean 11.14%; 3-dimensional conformal radiation therapy-planning target volume 105 mean 35.69%, P = .001). The dosimetric results of the remaining lung was below the limitations on intensity-modulated radiation therapy planning data (intensity-modulated radiation therapy-lung mean dose mean 7.5 [range: 5.6%-8.5%]; intensity-modulated radiation therapy-lung V5 mean 55.55% [range: 47%-59.9%]; intensity-modulated radiation therapy-lung V20 mean 4.5% [range: 0.5%-9.5%]; intensity-modulated radiation therapy-lung V13 mean 13.43% [range: 4.2%-22.9%]). Conclusion: With a complex and large target volume of malignant pleural mesothelioma, intensity-modulated radiation therapy has the ability to deliver efficient tumoricidal radiation dose within the safe dose limits of the remaining lung tissue.
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13

Ahn, Yong Chan. "Introduction of intensity modulated radiation therapy." Journal of the Korean Medical Association 54, no. 11 (2011): 1172. http://dx.doi.org/10.5124/jkma.2011.54.11.1172.

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14

Siochi, R. Alfredo C. "Virtual micro-intensity modulated radiation therapy." Medical Physics 27, no. 11 (November 2000): 2480–93. http://dx.doi.org/10.1118/1.1315314.

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15

Gaede, Stewart. "Optimization in intensity modulated radiation therapy." Medical Physics 31, no. 4 (April 2004): 952. http://dx.doi.org/10.1118/1.1655708.

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16

Cash, Jennifer C. "Changing Paradigms: Intensity Modulated Radiation Therapy." Seminars in Oncology Nursing 22, no. 4 (November 2006): 242–48. http://dx.doi.org/10.1016/j.soncn.2006.07.007.

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17

Low, D. A., J. F. Dempsey, J. Markman, S. Mutic, J. F. Williamson, and J. A. Purdy. "Applicator-guided intensity modulated radiation therapy." International Journal of Radiation Oncology*Biology*Physics 48, no. 3 (January 2000): 209. http://dx.doi.org/10.1016/s0360-3016(00)80212-6.

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18

Low, Daniel A., Perry W. Grigsby, James F. Dempsey, Sasa Mutic, Jeffrey F. Williamson, Jerry Markman, K. S. Clifford Chao, Eric E. Klein, and James A. Purdy. "Applicator-guided intensity-modulated radiation therapy." International Journal of Radiation Oncology*Biology*Physics 52, no. 5 (April 2002): 1400–1406. http://dx.doi.org/10.1016/s0360-3016(01)02798-5.

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19

Ito, Yoshinori. "Development of radiation therapy techniques including intensity-modulated radiation therapy." Annals of Oncology 27 (November 2016): vii64. http://dx.doi.org/10.1093/annonc/mdw509.

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20

Metcalfe, P., P. Tangboonduangjit, and P. White. "Intensity-modulated radiation therapy: overlapping co-axial modulated fields." Physics in Medicine and Biology 49, no. 16 (July 31, 2004): 3629–37. http://dx.doi.org/10.1088/0031-9155/49/16/010.

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21

Yoon, Han Gyul, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, and Seyjoon Park. "Early Clinical Outcomes of Intensity Modulated Radiation Therapy/Intensity Modulated Proton Therapy Combination in Comparison with Intensity Modulated Radiation Therapy Alone in Oropharynx Cancer Patients." Cancers 13, no. 7 (March 27, 2021): 1549. http://dx.doi.org/10.3390/cancers13071549.

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Purpose: To report the early clinical outcomes of combining intensity-modulated radiation therapy (IMRT) and intensity-modulated proton therapy (IMPT) in comparison with IMRT alone in treating oropharynx cancer (OPC) patients. Materials and Methods: The medical records of 148 OPC patients who underwent definitive radiotherapy (RT) with concurrent systemic therapy, from January 2016 till December 2019 at Samsung Medical Center, were retrospectively reviewed. During the 5.5 weeks’ RT course, the initial 16 (or 18) fractions were delivered by IMRT in all patients, and the subsequent 12 (or 10) fractions were either by IMRT in 81 patients (IMRT only) or by IMPT in 67 (IMRT/IMPT combination), respectively, based on comparison of adaptive re-plan profiles and availability of equipment. Propensity-score matching (PSM) was done on 76 patients (38 from each group) for comparative analyses. Results: With the median follow-up of 24.7 months, there was no significant difference in overall survival and progression free survival between groups, both before and after PSM. Before PSM, the IMRT/IMPT combination group experienced grade ≥ 3 acute toxicities less frequently: mucositis in 37.0% and 13.4% (p < 0.001); and analgesic quantification algorithm (AQA) in 37.0% and 19.4% (p = 0.019), respectively. The same trends were observed after PSM: mucositis in 39.5% and 15.8% (p = 0.021); and AQA in 47.4% and 21.1% (p = 0.016), respectively. In multivariate logistic regression, grade ≥ 3 mucositis was significantly less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.027 and 0.024, respectively). AQA score ≥ 3 was also less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.085 and 0.018, respectively). Conclusions: In treating the OPC patients, with comparable early oncologic outcomes, more favorable acute toxicity profiles were achieved following IMRT/IMPT combination than IMRT alone.
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22

Zhang, Shuming, Ruijie Yang, Chengyu Shi, Jiaqi Li, Hongqing Zhuang, Suqing Tian, and Junjie Wang. "Noncoplanar VMAT for Brain Metastases: A Plan Quality and Delivery Efficiency Comparison With Coplanar VMAT, IMRT, and CyberKnife." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381987162. http://dx.doi.org/10.1177/1533033819871621.

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Purpose: To compare plan quality and delivery efficiency of noncoplanar volumetric modulated arc therapy with coplanar volumetric modulated arc therapy, intensity-modulated radiation therapy, and CyberKnife for multiple brain metastases. Methods: For 15 patients with multiple brain metastases, noncoplanar volumetric modulated arc therapy, coplanar volumetric modulated arc therapy, intensity-modulated radiation therapy, and CyberKnife plans with a prescription dose of 30 Gy in 3 fractions were generated. Noncoplanar volumetric modulated arc therapy and coplanar volumetric modulated arc therapy plans consisted of 4 noncoplanar arcs and 2 full coplanar arcs, respectively. Intensity-modulated radiation therapy plans consisted of 7 coplanar fields. CyberKnife plans used skull tracking to ensure accurate position. All plans were generated to cover 95% target volume with prescription dose. Gradient index, conformity index, normal brain tissue volume ( V 3Gy − V 24Gy), monitor units, and beam on time were evaluated. Results: Gradient index was the lowest for CyberKnife (3.49 ± 0.65), followed by noncoplanar volumetric modulated arc therapy (4.21 ± 1.38), coplanar volumetric modulated arc therapy (4.87 ± 1.35), and intensity-modulated radiation therapy (5.36 ± 1.98). Conformity index was the largest for noncoplanar volumetric modulated arc therapy (0.87 ± 0.03), followed by coplanar volumetric modulated arc therapy (0.86 ± 0.04), CyberKnife (0.86 ± 0.07), and intensity-modulated radiation therapy (0.85 ± 0.05). Normal brain tissue volume at high-to-moderate dose spreads ( V 24Gy − V 9Gy) was significantly reduced in noncoplanar volumetric modulated arc therapy over that of intensity-modulated radiation therapy and coplanar volumetric modulated arc therapy. Normal brain tissue volume for noncoplanar volumetric modulated arc therapy was comparable with noncoplanar volumetric modulated arc therapy at high-dose level ( V 24Gy − V 15Gy) and larger than CyberKnife at moderate-to-low dose level ( V 12Gy − V 3Gy). Monitor units was highest for CyberKnife (28 733.59 ± 7197.85), followed by intensity-modulated radiation therapy (4128.40 ± 1185.38), noncoplanar volumetric modulated arc therapy (3105.20 ± 371.23), and coplanar volumetric modulated arc therapy (2997.27 ± 446.84). Beam on time was longest for CyberKnife (30.25 ± 7.32 minutes), followed by intensity-modulated radiation therapy (2.95 ± 0.85 minutes), noncoplanar volumetric modulated arc therapy (2.61 ± 0.07 minutes), and coplanar volumetric modulated arc therapy (2.30 ± 0.23 minutes). Conclusion: For brain metastases far away from organs-at-risk, noncoplanar volumetric modulated arc therapy generated more rapid dose falloff and higher conformity compared to intensity-modulated radiation therapy and coplanar volumetric modulated arc therapy. Noncoplanar volumetric modulated arc therapy provided a comparable dose falloff with CyberKnife at high-dose level and a slower dose falloff than CyberKnife at moderate-to-low dose level. Noncoplanar volumetric modulated arc therapy plans had less monitor units and shorter beam on time than CyberKnife plans.
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23

Chan, Timothy C. Y. "Motion-compensating intensity maps in intensity-modulated radiation therapy." IIE Transactions on Healthcare Systems Engineering 3, no. 1 (January 2013): 1–22. http://dx.doi.org/10.1080/19488300.2012.749436.

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24

Jani, Ashesh B., John C. Roeske, and Carla Rash. "Intensity-Modulated Radiation Therapy for Prostate Cancer." Clinical Prostate Cancer 2, no. 2 (September 2003): 98–105. http://dx.doi.org/10.3816/cgc.2003.n.016.

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25

NARITA, YUICHIRO, KAZUO HATANO, TAKAYUKI SHIMIZU, HIDEKI SHIMIZU, TSUTOMU IWASE, KIMIO UTAGAWA, HIDEYO ISHIGAKI, and YUKIO OKAZAKI. "Dosimetric Verification in Intensity Modulated Radiation Therapy." Japanese Journal of Radiological Technology 58, no. 6 (2002): 761–72. http://dx.doi.org/10.6009/jjrt.kj00001364468.

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26

NAGATA, Yasushi, Tetsuya AOKI, Takashi MIZOWAKI, Kenji TAKAYAMA, Michihide MITSUMORI, Sinsuke YANO, Masahiro HIRAOKA, Ryo ASATO, and Shinzo TANAKA. "INTENSITY-MODULATED RADIATION THERAPY FOR NASOPHARYNGEAL CANCER." Japanese jornal of Head and Neck Cancer 29, no. 1 (2003): 151–58. http://dx.doi.org/10.5981/jjhnc1974.29.151.

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27

Vicini, Frank A., Michael Sharpe, Larry Kestin, Alvaro Martinez, and John Wong. "Intensity-Modulated Radiation Therapy for Breast Cancer." American Journal of Cancer 1, no. 4 (2002): 237–45. http://dx.doi.org/10.2165/00024669-200201040-00001.

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28

Schüler, Emil, Lei Wang, Billy W. Loo, and Peter G. Maxim. "Conical beam geometry intensity-modulated radiation therapy." Physics in Medicine & Biology 64, no. 12 (June 20, 2019): 125014. http://dx.doi.org/10.1088/1361-6560/ab246f.

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29

Call, Jason A., Brendan M. Prendergast, Lindsay G. Jensen, Celine B. Ord, Karyn A. Goodman, Rojymon Jacob, Loren K. Mell, Charles R. Thomas, Salma K. Jabbour, and Robert C. Miller. "Intensity-modulated Radiation Therapy for Anal Cancer." American Journal of Clinical Oncology 39, no. 1 (February 2016): 8–12. http://dx.doi.org/10.1097/coc.0000000000000009.

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30

Konski, Andre. "Cost–effectiveness of intensity-modulated radiation therapy." Expert Review of Pharmacoeconomics & Outcomes Research 5, no. 2 (April 2005): 137–40. http://dx.doi.org/10.1586/14737167.5.2.137.

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31

Li, H., J. P. Bissonnette, T. Purdie, and T. C. Y. Chan. "Robust PET-guided intensity-modulated radiation therapy." Medical Physics 42, no. 8 (July 28, 2015): 4863–71. http://dx.doi.org/10.1118/1.4926845.

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32

Zelefsky, Michael J., Zvi Fuks, and Steven A. Leibel. "Intensity-modulated radiation therapy for prostate cancer." Seminars in Radiation Oncology 12, no. 3 (July 2002): 229–37. http://dx.doi.org/10.1053/srao.2002.00000.

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33

Uy, Nathan W., Shiao Y. Woo, Bin S. Teh, Wei-Yuan Mai, L. Steven Carpenter, Joseph K. Chiu, Hsin H. Lu, et al. "Intensity-modulated radiation therapy (IMRT) for meningioma." International Journal of Radiation Oncology*Biology*Physics 53, no. 5 (August 2002): 1265–70. http://dx.doi.org/10.1016/s0360-3016(02)02823-7.

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34

Mundt, Arno J., John C. Roeske, and Anthony E. Lujan. "Intensity-modulated radiation therapy in gynecologic malignancies." Medical Dosimetry 27, no. 2 (June 2002): 131–36. http://dx.doi.org/10.1016/s0958-3947(02)00095-x.

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35

Saw, Cheng B., Komanduri M. Ayyangar, Weining Zhen, Maung Yoe-sein, Susha Pillai, and Charles A. Enke. "Clinical implementation of intensity-modulated radiation therapy." Medical Dosimetry 27, no. 2 (June 2002): 161–69. http://dx.doi.org/10.1016/s0958-3947(02)00099-7.

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36

Romeijn, H. Edwin, and James F. Dempsey. "Intensity modulated radiation therapy treatment plan optimization." TOP 16, no. 2 (November 4, 2008): 215–43. http://dx.doi.org/10.1007/s11750-008-0064-1.

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37

Schroeder, Thomas M., Murali Chintagumpala, M. Fatih Okcu, J. Kam Chiu, Bin S. Teh, Shiao Y. Woo, and Arnold C. Paulino. "Intensity-Modulated Radiation Therapy in Childhood Ependymoma." International Journal of Radiation Oncology*Biology*Physics 71, no. 4 (July 2008): 987–93. http://dx.doi.org/10.1016/j.ijrobp.2007.11.058.

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38

Goyal, Sharad, Alan Cohler, Jayne Camporeale, Venkat Narra, and Ning J. Yue. "Intensity-modulated radiation therapy for orbital lymphoma." Radiation Medicine 26, no. 10 (December 2008): 573–81. http://dx.doi.org/10.1007/s11604-008-0276-1.

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39

Palta, Jatinder R., Chihray Liu, and Jonathan G. Li. "Quality Assurance of Intensity-Modulated Radiation Therapy." International Journal of Radiation Oncology*Biology*Physics 71, no. 1 (May 2008): S108—S112. http://dx.doi.org/10.1016/j.ijrobp.2007.05.092.

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40

Roesink, Judith M. "Salivary Flow and Intensity-modulated Radiation Therapy." European Oncology & Haematology 00, no. 02 (2007): 113. http://dx.doi.org/10.17925/eoh.2007.0.2.113.

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41

Nutting, C., D. P. Dearnaley, and S. Webb. "Intensity modulated radiation therapy: a clinical review." British Journal of Radiology 73, no. 869 (May 2000): 459–69. http://dx.doi.org/10.1259/bjr.73.869.10884741.

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42

Fox, Christopher, H. Edwin Romeijn, Bart Lynch, Chunhua Men, Dionne M. Aleman, and James F. Dempsey. "Comparative analysis of60Co intensity-modulated radiation therapy." Physics in Medicine and Biology 53, no. 12 (May 27, 2008): 3175–88. http://dx.doi.org/10.1088/0031-9155/53/12/007.

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43

Yu, Cedric, David Shepard, Matt Earl, Daliang Cao, Shuang Luan, Chao Wang, and Danny Z. Chen. "New Developments in Intensity Modulated Radiation Therapy." Technology in Cancer Research & Treatment 5, no. 5 (October 2006): 451–64. http://dx.doi.org/10.1177/153303460600500502.

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44

Boyer, Arthur L. "The Physics of Intensity-Modulated Radiation Therapy." Physics Today 55, no. 9 (September 2002): 38–43. http://dx.doi.org/10.1063/1.1522214.

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45

Ehrgott, Matthias, Çiğdem Güler, Horst W. Hamacher, and Lizhen Shao. "Mathematical optimization in intensity modulated radiation therapy." Annals of Operations Research 175, no. 1 (November 5, 2009): 309–65. http://dx.doi.org/10.1007/s10479-009-0659-4.

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46

Ehrgott, Matthias, Çiğdem Güler, Horst W. Hamacher, and Lizhen Shao. "Mathematical optimization in intensity modulated radiation therapy." 4OR 6, no. 3 (August 15, 2008): 199–262. http://dx.doi.org/10.1007/s10288-008-0083-7.

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47

Salama, Joseph K., John C. Roeske, Neil Mehta, and Arno J. Mundt. "Intensity-modulated radiation therapy in gynecologic malignancies." Current Treatment Options in Oncology 5, no. 2 (March 2004): 97–108. http://dx.doi.org/10.1007/s11864-004-0042-2.

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48

Meyer, Jeffrey J., Brian G. Czito, and Christopher G. Willett. "Intensity-modulated radiation therapy for gastrointestinal tumors." Current Oncology Reports 10, no. 3 (May 2008): 206–11. http://dx.doi.org/10.1007/s11912-008-0032-9.

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49

Gaspar, Laurie E., and Meisong Ding. "A review of intensity-modulated radiation therapy." Current Oncology Reports 10, no. 4 (July 2008): 294–99. http://dx.doi.org/10.1007/s11912-008-0046-3.

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50

Potters, Louis, Michael Steinberg, Paul Wallner, and James Hevezi. "How one defines intensity-modulated radiation therapy." International Journal of Radiation Oncology*Biology*Physics 56, no. 3 (July 2003): 609–10. http://dx.doi.org/10.1016/s0360-3016(03)00205-0.

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