Academic literature on the topic 'Integrin with metal ions'

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Journal articles on the topic "Integrin with metal ions"

1

Powell, J. J., R. Jugdaohsingh, and R. P. H. Thompson. "The regulation of mineral absorption in the gastrointestinal tract." Proceedings of the Nutrition Society 58, no. 1 (1999): 147–53. http://dx.doi.org/10.1079/pns19990020.

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The absorption of metal ions in the mammalian single-stomached gut is fortunately highly selective, and both luminal and tissue regulation occur. Initially, assimilation of metal ions in an available form is facilitated by the intestinal secretions, chiefly soluble mucus (mucin) that retards hydrolysis of ions such as Cu, Fe and Zn. Metal ions then bind and traverse the mucosally-adherent mucus layer with an efficiency M+> M2+> M3+. At the mucosa Fe3+is probably uniquely reduced to Fe2+, and all divalent cations (including Fe2+) are transported by a membrane protein (such as divalent cation transporter 1) into the cell. This minimizes absorption of toxic trivalent metals (e.g. A13+). Intracellular metal-binding molecules (such as mobilferrin) may be present at the intracellular side of the apical membrane, anchored to a transmembrane protein such as an integrin complex. This mobilferrin would receive the metal ion from divalent cation transporter 1 and, with part of the integrin molecule, transport the metal to the cytosol for safe sequestration in a larger complex such as ferritin or‘paraferritin’. β2-Microglobulin and HFE (previously termed human leucocyte antigen H) may be involved in stabilizing metal mobilferrin-integrin to form this latter complex. Finally, a systemic metal-binding protein such as transferrin may enter the antiluminal (basolateral) side of the cell for binding of the sequestered metal ion and delivery to the circulation. Regulatory proteins, such as HFE, may determine the degree of ion transport from intestinal cells to the circulation. Gradients in pH and perhaps pCa or even pNa could allow the switching of ions between the different transporters throughout this mechanism.
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2

Huang, Hao, Joel N. Bogstie, and Hans J. Vogel. "Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences." Biochemistry and Cell Biology 90, no. 5 (2012): 646–56. http://dx.doi.org/10.1139/o2012-021.

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The human calcium- and integrin-binding protein 1 (CIB1) plays important roles in various cellular functions. In this study, three other members of this protein family (CIB2–4: CIB2, CIB3, and CIB4) were purified and subsequently characterized using biophysical and structural approaches. As expected from sequence alignments, CIB2–4 were shown to bind calcium (Ca2+) and magnesium (Mg2+) ions. Binding of Ca2+ or Mg2+ ions changes the secondary structure of CIB2–4 and the exposure of hydrophobic surface area. Ca2+ and Mg2+ ions also stabilize the tertiary structures for CIB2 and CIB3. Through in vitro binding experiments, we show that CIB2 can interact with the integrin αIIb cytoplasmic domain and the integrin α7b membrane-proximal fragment. Fluorescence experiments using a 7-azatryptophan labeled peptide demonstrate that CIB2, CIB3, and CIB4 are binding partners for the integrin αIIb subunit, which suggests that they are potentially involved in regulating integrin αIIb subunit activation. The distinct responses of αIIb to the different CIB3 and CIB4 metal (Ca2+ and Mg2+) binding states imply a potential connection between the calcium and integrin signaling pathways.
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3

Schumacher, Stephanie, Dirk Dedden, Roberto Vazquez Nunez та ін. "Structural insights into integrin α5β1 opening by fibronectin ligand". Science Advances 7, № 19 (2021): eabe9716. http://dx.doi.org/10.1126/sciadv.abe9716.

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Integrin α5β1 is a major fibronectin receptor critical for cell migration. Upon complex formation, fibronectin and α5β1 undergo conformational changes. While this is key for cell-tissue connections, its mechanism is unknown. Here, we report cryo–electron microscopy structures of native human α5β1 with fibronectin to 3.1-angstrom resolution, and in its resting state to 4.6-angstrom resolution. The α5β1-fibronectin complex revealed simultaneous interactions at the arginine-glycine-aspartate loop, the synergy site, and a newly identified binding site proximal to adjacent to metal ion–dependent adhesion site, inducing the translocation of helix α1 to secure integrin opening. Resting α5β1 adopts an incompletely bent conformation, challenging the model of integrin sharp bending inhibiting ligand binding. Our biochemical and structural analyses showed that affinity of α5β1 for fibronectin is increased with manganese ions (Mn2+) while adopting the half-bent conformation, indicating that ligand-binding affinity does not depend on conformation, and α5β1 opening is induced by ligand-binding.
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4

Ajroud, Kaouther, Takashi Sugimori, Wolfgang H. Goldmann, Dahmani M. Fathallah, Jian-Ping Xiong, and M. Amin Arnaout. "Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands." Journal of Biological Chemistry 279, no. 24 (2004): 25483–88. http://dx.doi.org/10.1074/jbc.m402901200.

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5

Michalska, Agnieszka, Sebastian Golczak, Krzysztof Langer, and Jerzy Langer. "Micro- and Nanostructured Polyaniline for Instant Identification of Metal Ions in Solution." Nanomaterials 9, no. 2 (2019): 231. http://dx.doi.org/10.3390/nano9020231.

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The unique properties of nanomaterials enable the creation new analytical devices. Polyaniline (PANI) micro- and nanofiber network, freestanding in the gap between two gold microelectrodes, has been used in a new nanodetector for metal ions in solutions. The gold electrodes were modified with the aid of alkanethiols, forming a self-assembled monolayer (SAM), which is able to block the ion current flow, but also to interact with metal ions when specific functional molecules are incorporated into the layer. The electric field of the trapped metal ions induces change of the electrical conductivity of polyaniline nanofibers in vicinity. A small injected sample (75 μL) of a solution of salt (about 0.5 μg of salt) was enough to induce a reproducible change in the electrical conductivity of polyaniline nano-network, which was registered as a function of time within 10–20 s. The response was proportional to the concentration of ions. It also depends on properties of ions, e.g., the ionic radius, which allows for identification of metal ions by analyzing the parameters of the signal: the retention time (RT), half width (HW), amplitude (A) and integral intensity (INT). The advantage of the new device is the instant responsiveness and easy operation, but also the simple construction based on organic (polymer) technology. The system is “open”—when learned and calibrated adequately, other metal ions can be analyzed. The nanodetector can be used in cases where monitoring of the presence and concentration of metal ions is important.
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6

Shamanin V.I. and Tarbokov V.A. "Multicharged metal ions generation in a self-magnetically insulated ion diode." Technical Physics Letters 49, no. 5 (2023): 63. http://dx.doi.org/10.21883/tpl.2023.05.56032.19507.

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A self-magnetically insulated ion diode was used to produce a pulsed beam of metallic ions from explosion emission plasma. The ratio of integral transferred charge for the Al, Ti and Mo ions amounted to at least 63% to the total beam charge. The ion diode had design features, which consisted in a bladed cathode and a removable perforated anode overlay made of VT-8 alloy. Analysis of the charge to mass characteristics of beam ions and the ion current density waveforms by the time of flight methodic with use of a Faraday cup showed the content of aluminum and titanium ions in the third to fourth states of ionization. Keywords: ion diode, metal ions, magnetic spectrometer, track detector CR-39.
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7

Kavitha, Govindarajan, Parasuraman Vijaya Rohini, and Sunkubangaru Sudarsan Alwar. "Potentiometric Studies of Binary Complexes of Transition Metal Ions with Lauric Acid." Oriental Journal of Chemistry 34, no. 5 (2018): 2681–84. http://dx.doi.org/10.13005/ojc/340564.

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The potentials of binary complexes of the Lauric acid ligand with various biologically vital divalent metal ions such as Mn(II), Co(II), Ni(II), Cu(II)and Zn(II) have been studied in 50% DMSO-water mixture at constant ionic strength by Bjerrum method. Hydrogen ion concentrations were measured and the formation of binary complexes was inferred from the corresponding potentiometric pH-titration curves. The metal to ligand mole ratio was maintained at 1:5 to facilitate the maximum number of ligands to the metal ion. The dissociation constant has been determined by the half-integral method and pointwise method and were found in good agreement with each other. The Metal-Lauric acid stability constants have been calculated and compared with the results.
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8

Gupta, Neelmani, Murari Prasad, Nidhi Singhal, and Vineet Kumar. "Modeling the Adsorption Kinetics of Divalent Metal Ions onto Pyrophyllite Using the Integral Method." Industrial & Engineering Chemistry Research 48, no. 4 (2009): 2125–28. http://dx.doi.org/10.1021/ie800975m.

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9

Singhal, Nidhi, Murari Prasad, Neelmani Gupta, and Vineet Kumar. "Modeling the sorption kinetics of divalent metal ions onto mineral adsorbent using integral method." Journal of Colloid and Interface Science 313, no. 2 (2007): 423–27. http://dx.doi.org/10.1016/j.jcis.2007.04.068.

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10

Kolmas, Joanna, Ewa Groszyk, and Dagmara Kwiatkowska-Różycka. "Substituted Hydroxyapatites with Antibacterial Properties." BioMed Research International 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/178123.

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Reconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of infection is often associated with an unfavourable ratio of dosage efficiency and toxic effect. Thus, the present study aims to find a new factor which may improve antibacterial activity while also presenting low toxicity to the human cells. Such factors are usually implemented along with the implant itself and may be an integral part of it. Many recent studies have focused on inorganic factors, such as metal nanoparticles, salts, and metal oxides. The advantages of inorganic factors include the ease with which they can be combined with ceramic and polymeric biomaterials. The following review focuses on hydroxyapatites substituted with ions with antibacterial properties. It considers materials that have already been applied in regenerative medicine (e.g., hydroxyapatites with silver ions) and those that are only at the preliminary stage of research and which could potentially be used in implantology or dentistry. We present methods for the synthesis of modified apatites and the antibacterial mechanisms of various ions as well as their antibacterial efficiency.
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