Academic literature on the topic 'Insulin signalling'
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Journal articles on the topic "Insulin signalling"
Bevan, Paul. "Insulin signalling." Journal of Cell Science 114, no. 8 (January 1, 2001): 1429–30. http://dx.doi.org/10.1242/jcs.114.8.1429.
Full textNystrom, Fredrik H., and Michael J. Quon. "Insulin Signalling." Cellular Signalling 11, no. 8 (August 1999): 563–74. http://dx.doi.org/10.1016/s0898-6568(99)00025-x.
Full textPersaud, Shanta J., Dany Muller, and Peter M. Jones. "Insulin signalling in islets." Biochemical Society Transactions 36, no. 3 (May 21, 2008): 290–93. http://dx.doi.org/10.1042/bst0360290.
Full textHeinrichs, Arianne. "PTEN and insulin signalling." Trends in Molecular Medicine 7, no. 5 (May 2001): 200. http://dx.doi.org/10.1016/s1471-4914(01)02037-8.
Full textLizcano, Jose M., and Dario R. Alessi. "The insulin signalling pathway." Current Biology 12, no. 7 (April 2002): R236—R238. http://dx.doi.org/10.1016/s0960-9822(02)00777-7.
Full textJiang, G., and B. B. Zhang. "Modulation of insulin signalling by insulin sensitizers." Biochemical Society Transactions 33, no. 2 (April 1, 2005): 358–61. http://dx.doi.org/10.1042/bst0330358.
Full textPathak, Himani, and Jishy Varghese. "Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila." Life Science Alliance 4, no. 8 (June 17, 2021): e202101079. http://dx.doi.org/10.26508/lsa.202101079.
Full textVillalobos-Labra, Roberto, Luis Silva, Mario Subiabre, Joaquín Araos, Rocío Salsoso, Bárbara Fuenzalida, Tamara Sáez, et al. "Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy." Journal of Diabetes Research 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/5947859.
Full textBertrand, L., S. Horman, C. Beauloye, and J. L. Vanoverschelde. "Insulin signalling in the heart." Cardiovascular Research 79, no. 2 (April 30, 2008): 238–48. http://dx.doi.org/10.1093/cvr/cvn093.
Full textLevy, Jonathan C. "Insulin signalling through ultradian oscillations." Growth Hormone & IGF Research 11 (June 2001): S17—S23. http://dx.doi.org/10.1016/s1096-6374(01)80004-6.
Full textDissertations / Theses on the topic "Insulin signalling"
Philippeos, Christina. "Insulin signalling in endothelial cells." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/insulin-signalling-in-endothelial-cells(8e35db48-dc9c-41be-b1aa-1fbe241fc356).html.
Full textJoharatnam, Jalini. "Insulin signalling in granulosa cells." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9784.
Full textCollison, Mary Williamson. "Insulin signalling in insulin resistance and cardiovascular disease syndromes." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366184.
Full textAlves, Steven Ribeiro. "The relevence of insulin signalling in Alzheimer's disease." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22020.
Full textAlzheimer’s disease (AD) is the most common type of dementia worldwide. It is molecularly characterized by deposition of extracellular senile plaques (SPs) composed by aggregated amyloid beta (Aβ) peptide, the formation of neurofibrillary tangles (NFTs) derived from hyperphosphorylation of the microtubule-associated protein Tau, synaptic dysfunction due to the deposits of SPs and NFTs and oxidative stress induced by impaired metabolic pathways. The insulin signalling pathway can play a major role in diverse AD related pathways, such as APP cleavage, Tau hyperphosphorylation, Apolipoprotein E (ApoE) influence in insulin signalling efficiency and the insulin degrading enzyme, which is also the major Aβ degrading enzyme. Growing evidence links AD with type 2 diabetes (T2D) due to impaired insulin signalling (IS) and brain insulin resistance. In a cohort based study in the Aveiro region, a correlation between diabetes and poor cognitive scores in the Mini Mental State Examination (MMSE) test were observed, with a p-value of 0.072. Additionally, carriers of the allele ApoE-ɛ2 appeared to be protective against diabetes, in the literature the same allele appears to be protective for AD. Posteriorly, the analysis of protein interactions, via the development of interactome networks, identified several proteins involved in both AD and the IS pathways. Also, by correlating these pathways with the synapse proteome, a very high overlap was observed (88% for AD, 79% for IS and 96% for AD and IS coincident proteins), enforcing the importance of both pathways in synaptic signalling and plasticity. From gene ontology studies, it was possible to assess the principal biological processes and molecular functions of the dataset of proteins. For AD, response to stimulus, cellular component organization, cell communication, signalling, protein binding, receptor binding and kinase binding were categories with elevated representation. Regarding coincident proteins between AD and IS pathways, an increase in all categories was observed, meaning that insulin plays a pivotal role in many AD events. Finally, the analysis of SH-SY5Y differentiated cells treated with 0, 1, 10 and 100 nM of insulin for 0, 10 and 60 minutes, showed a decrease on the intracellular total levels of protein Tau and an increase in the phosphorylation at serine 396. Regarding the amyloid precursor protein (APP), increases in intracellular levels were observed, when treated with insulin for 10 minutes, followed by a decrease for 60 minutes exposure. The phosphorylation of APP at threonine 668, has previously been related to increased production of Aβ, by promoting APP cleavage via the amyloidogenic pathway. In cells treated with insulin, a clear increase was detected at the 10-minute time point. At 60 minutes, the levels of phosphorylation were low probably due to low total APP levels.
A doença de Alzheimer (DA) é o tipo mais comum de demência no mundo. É caracterizada molecularmente pela deposição extracelular de placas senis (PS) compostas por agregados do péptido amiloide beta (Aβ), pela formação de emaranhados neurofibrilares (EN) derivados da hiperfosforilação da proteína Tau, pela disfunção sináptica devido aos depósitos de PS e EN e também pelo stress oxidativo induzido pelo enfraquecimento das vias metabólicas. A via de sinalização da insulina desempenha um papel principal em diversas vias da DA, tal como na clivagem da APP, hiperfosforilação da proteína Tau, eficiência da sinalização da insulina influenciada pela Apolipoproteína E (ApoE) e pela enzima envolvida na degradação de insulina que também é a enzima principal na degradação de Aβ. Crescente evidência relaciona a DA com a diabetes de tipo 2 (T2D) devido ao mau funcionamento da sinalização pela insulina e da resistência cerebral à mesma. Num estudo baseado num cohort da região de Aveiro, foi observada uma correlação entre a diabetes e um mau resultado no teste do ‘Mini Mental State Examination’. Adicionalmente, também foi observada uma correlação entre os portadores do alelo ApoE-ɛ2 e um estado protetor contra a T2D. Este alelo também foi observado na literatura como sendo protetor contra a DA. Posteriormente, uma análise de interações entre proteínas, identificou várias proteínas envolvidas tanto na DA como na sinalização da insulina. Correlacionando estes dados com o proteoma da sinapse, foi possível observar que existe uma grande representação das duas condições e também das proteínas coincidentes às duas (88% para a DA, 79% para a sinalização da insulina e 96% para as proteínas relacionadas com ambas), reforçando o papel de ambas as vias na sinalização e plasticidade sináptica. Do estudo de ontologia genética para a DA, foi possível identificar diversas vias importantes, tais como, resposta a um estímulo, organização de componentes celulares, comunicação celular, ligação proteica e ligação a uma cinase. Em relação à sinalização da insulina, as mesmas categorias apareciam com maior representação, significando que a insulina tem um papel importante em muitos eventos da DA. Por fim, o tratamento de SH-SY5Y diferenciadas com 0, 1, 10 e 100 nM de insulina por 0, 10 e 60 minutos mostraram uma diminuição nos níveis intracelulares da proteína Tau e um aumento na sua fosforilação na serina 396. Em relação à proteína percursora amiloide (APP), o tratamento de insulina levou a um aumento nos níveis intracelulares, quando exposta por 10 minutos seguido por uma diminuição aos 60 minutos. Quanto à fosforilação da treonina 668 da APP, foi previamente demonstrado que um aumento na fosforilação desse resíduo, promove a clivagem pela via amiloidogénica, levando à produção de Aβ. Nas células tratadas com insulina, um aumento claro da fosforilação desse resíduo da APP foi observado aos 10 minutos. Aos 60 minutos, os níveis da fosforilação eram baixos provavelmente devido aos baixos níveis de APP total.
Ng, Foong Loo Yvonne Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Insulin action: unravelling AKT signalling in Adipocytes." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44628.
Full textBray, Jonathan Alexander. "Comparing insulin and insulin-like growth factor-1 signalling in myoblasts." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596876.
Full textMercer, Ben N. "Does altered insulin signalling modulate vascular regeneration?" Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/7069/.
Full textMusial, Barbara. "Regulation of insulin signalling during mouse pregnancy." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708844.
Full textWuttke, Anne. "Lipid Signalling Dynamics in Insulin-secreting β-cells." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198046.
Full textWiggins, Emma Louise. "Regulation of myogenesis by IGF- and insulin-signalling." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608747.
Full textBooks on the topic "Insulin signalling"
Au, Crystal Suet Ying. Modulation of insulin signalling molecules and hepatic lipoprotein production. Ottawa: National Library of Canada, 2003.
Find full textYang, Shen-Hsui. Insulin signalling pathways involved in selective control of hepatic gene expression. Manchester: University of Manchester, 1995.
Find full textBelbrahem, Atika. Characterisation of protein Kinase C in chick embryo tissues and hepatocytes: Role in insulin signalling. Manchester: University of Manchester, 1994.
Find full textVafopoulou, Xanthe, and Colin G. H. Steel, eds. The Coming of Age of Insulin-Signalling in Insects. Frontiers SA Media, 2015. http://dx.doi.org/10.3389/978-2-88919-314-1.
Full text(Editor), Derek LeRoith, Walter Zumkeller (Editor), and Robert C. Baxter (Editor), eds. Insulin-like Growth Factor Receptor Signalling (Molecular Biology Intelligence Unit). Springer, 2003.
Find full textPatel, Nish. Insulin-induced actin remodelling and the localization of signalling molecules. 2006.
Find full textFunction of receptor tyrosine kinases in Gi-deficient cells: Preferential suppression of insulin signalling. Ottawa: National Library of Canada, 2000.
Find full textBook chapters on the topic "Insulin signalling"
Hollenberg, M. D. "Insulin Receptor-Mediated Transmembrane Signalling." In Insulin, 183–207. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74098-5_10.
Full textGuglielmo, Gianni M. Di, Paul G. Drake, Patricia C. Baass, François Authier, Barry I. Posner, and John J. M. Bergeron. "Insulin receptor internalization and signalling." In Insulin Action, 59–63. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_6.
Full textSiddle, Ken. "The Insulin Receptor and Downstream Signalling." In Insulin Resistance, 1–62. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470011327.ch1.
Full textOgawa, Wataru, Takashi Matozaki, and Masato Kasuga. "Role of binding proteins to IRS-1 in insulin signalling." In Insulin Action, 13–22. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_2.
Full textGoldstein, Barry J., Faiyaz Ahmad, Wendi Ding, Pei-Ming Li, and Wei-Ren Zhang. "Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases." In Insulin Action, 91–99. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_10.
Full textWhite, Morris F. "The IRS-signalling system: A network of docking proteins that mediate insulin action." In Insulin Action, 3–11. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_1.
Full textKhadka, Deegendra. "Ameliorating Insulin Signalling Pathway by Phytotherapy." In Ethnopharmacology of Wild Plants, 317–42. First edition. | Boca Raton : CRC Press, 2021.: CRC Press, 2021. http://dx.doi.org/10.1201/9781003052814-17.
Full textLiu, Feng, and Richard A. Roth. "Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling." In Insulin Action, 73–78. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_8.
Full textAn, Seon Woo A., Murat Artan, Sangsoon Park, Ozlem Altintas, and Seung-Jae V. Lee. "Longevity Regulation by Insulin/IGF-1 Signalling." In Healthy Ageing and Longevity, 63–81. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44703-2_4.
Full textVarela, Isabel, Jose F. Alvarez, Jose Puerta, Rosa Clemente, Ana Guadaño, Matias Avila, Francisco Estevez, Susana Alemany, and Jose M. Mato. "Role of Glycosyl-Phosphatidylinositols in Insulin Signalling." In Activation and Desensitization of Transducing Pathways, 167–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-83618-3_10.
Full textConference papers on the topic "Insulin signalling"
Vlahos, R., C. Mastronardo, H. J. Seow, and S. M. Chan. "Apocynin Opposes Oxidative Stress-Induced Atrophy by Preserving Insulin Like Growth Factor (IGF)-1 Signalling in C2C12 Myotubes." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2376.
Full textDodd, MS, Mdl Sousa Fialho, CN Montes Aparico, M. Kerr, KN Timm, JL Griffin, JJFP Luiken, JFC Glatz, DJ Tyler, and LC Heather. "P27 Depletion of cardiac succinate mediates impaired hypoxia-inducible factor 1Α signalling by long chain fatty acids in insulin resistance." In British Society for Cardiovascular Research, Autumn Meeting 2017 ‘Cardiac Metabolic Disorders and Mitochondrial Dysfunction’, 11–12 September 2017, University of Oxford. BMJ Publishing Group Ltd and British Cardiovascular Society, 2018. http://dx.doi.org/10.1136/heartjnl-2018-bscr.32.
Full textErlandsson, M., M. Nadali, S. Silfverswärd Töyrä, MN Svensson, I.-M. Jonsson, KM Andersson, and MI Bokarewa. "SAT0026 Signalling through insulin-like growth factor 1 receptor contributes to il-6 production and supports t cell dependent inflammation in rheumatoid arthritis." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.6191.
Full textReports on the topic "Insulin signalling"
Lekhanya, Portia Keabetswe, and Kabelo Mokgalaboni. Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetic neuropathy. Protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0167.
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