Academic literature on the topic 'Insulin receptor gene'
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Journal articles on the topic "Insulin receptor gene"
Seino, S., M. Seino, and G. I. Bell. "Human Insulin-Receptor Gene." Diabetes 39, no. 2 (February 1, 1990): 129–33. http://dx.doi.org/10.2337/diab.39.2.129.
Full textSeino, S., M. Seino, and G. I. Bell. "Human insulin-receptor gene." Diabetes 39, no. 2 (February 1, 1990): 129–33. http://dx.doi.org/10.2337/diabetes.39.2.129.
Full textBrunetti, Antonio, and I. D. Goldfine. "Insulin receptor gene expression and insulin resistance." Journal of Endocrinological Investigation 18, no. 5 (May 1995): 398–405. http://dx.doi.org/10.1007/bf03347847.
Full textMorris, Brian J. "Insulin Receptor Gene in Hypertension." Clinical and Experimental Hypertension 19, no. 5-6 (January 1997): 551–65. http://dx.doi.org/10.3109/10641969709083169.
Full textGreenhill, Claire. "Insulin and the insulin receptor regulate gene expression." Nature Reviews Endocrinology 15, no. 6 (April 11, 2019): 315. http://dx.doi.org/10.1038/s41574-019-0206-6.
Full textSoler, A. P., K. A. Thompson, R. M. Smith, and L. Jarett. "Immunological demonstration of the accumulation of insulin, but not insulin receptors, in nuclei of insulin-treated cells." Proceedings of the National Academy of Sciences 86, no. 17 (September 1989): 6640–44. http://dx.doi.org/10.1073/pnas.86.17.6640.
Full textRojek, Aleksandra, and Marek Niedziela. "Insulin Receptor and its Relationship with Different Forms of Insulin Resistance." Advances in Cell Biology 2, no. 2 (February 1, 2010): 59–90. http://dx.doi.org/10.2478/v10052-010-0004-8.
Full textTAYLOR, SIMEON I., ALESSANDRO CAMA, DOMENICO ACCILI, FABRIZIO BARBETTI, MICHAEL J. QUON, MARIA DE LA LUZ SIERRA, YOSHIFUMI SUZUKI, et al. "Mutations in the Insulin Receptor Gene." Endocrine Reviews 13, no. 3 (August 1992): 566–95. http://dx.doi.org/10.1210/edrv-13-3-566.
Full textTaylor, S. I., T. Kadowaki, H. Kadowaki, D. Accili, A. Cama, and C. McKeon. "Mutations in Insulin-Receptor Gene in Insulin-Resistant Patients." Diabetes Care 13, no. 3 (March 1, 1990): 257–79. http://dx.doi.org/10.2337/diacare.13.3.257.
Full textKitamura, Tadahiro, Yoshiaki Kido, Serge Nef, Jussi Merenmies, Luis F. Parada, and Domenico Accili. "Preserved Pancreatic β-Cell Development and Function in Mice Lacking the Insulin Receptor-Related Receptor." Molecular and Cellular Biology 21, no. 16 (August 15, 2001): 5624–30. http://dx.doi.org/10.1128/mcb.21.16.5624-5630.2001.
Full textDissertations / Theses on the topic "Insulin receptor gene"
Gletsu, Nana Adwoa. "Insulin receptor translocation to the hepatocyte nucleus, regulation of gene expression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ29039.pdf.
Full textPatel, Dhaval Subhas. "Analysis of the daf-2 insulin/igf-1 receptor gene in Caenorhabditis elegans." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445066/.
Full textGriffiths, Matthew Rhodri. "Analysis of signal transduction pathways involved in the activation of gene transcription by the insulin receptor." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265456.
Full textTsukumo, Daniela Miti Lemos 1976. "Mutação inativadora do TLR4 protege contra a obesidade e a restencia a insulina induzidas por dieta hiperlipidica." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311220.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-11T03:34:45Z (GMT). No. of bitstreams: 1 Tsukumo_DanielaMitiLemos_D.pdf: 7330041 bytes, checksum: 384133bd9ed3dd468d57225845733901 (MD5) Previous issue date: 2008
Resumo: Estudos recentes demonstram que a obesidade está associada com a resistência à insulina e com um estado de inflamação crônica subclínica. Os ¿Toll-Like Receptors¿ (TLRs) têm um papel fundamental na ativação do sistema imune através do reconhecimento de antígenos de microorganismos. O TLR4 é um subtipo de TLRs que é ativado pelo lipopolissacarídeo de bactérias gram-negativas e por outros agonistas, como os ácidos graxos saturados. A ativação do TLR4 estimula vias inflamatórias relacionadas à indução de resistência à insulina, como a JNK e a IKKß. Neste estudo, demonstrou-se que camundongos C3H/HeJ, que apresentam uma mutação inativadora do TLR4, estão protegidos da obesidade e da resistência à insulina induzidas por dieta hiperlipídica. Além disso, músculos sóleos isolados de camundongos C3H/HeJ estão protegidos da resistência à insulina induzida por ácidos graxos. Camundongos C3H/HeJ tratados com dieta hiperlipídica (DH) apresentam um menor ganho de peso, maior tolerância à glicose e maior sensibilidade à insulina em relação aos controles em DH. A análise morfométrica do tecido adiposo evidenciou que os adipócitos dos camundongos C3H/HeJ em DH são 30% menores em relação aos adipócitos dos camundongos controle tratados com a mesma dieta. Foi evidenciada uma maior fosforilação em tirosina do IRS-1 e maior fosforilação da Akt, após estímulo com insulina, em músculo, tecido adiposo e fígado de camundongos C3H/HeJ tratados com DH em relação aos controles. Observou-se uma maior ativação da JNK, da IKKß e da iNOS em músculo, tecido adiposo e fígado de animais controle tratados com DH quando comparado com camundongos C3H/HeJ tratados com a mesma dieta. O tratamento com palmitato reduziu a captação de glicose e a síntese de glicogênio em 40-50% em músculo sóleo isolado de camundongos controle, mas este efeito não foi observado em músculo sóleo isolado de camundongos C3H/HeJ. Em resumo, o nosso estudo demonstra que a inativação do TLR4 previne a obesidade induzida por dieta, a ativação da IKKß, da JNK, a resistência à insulina em camundongos em DH, além da resistência à insulina induzida por palmitato em músculo isolado. O estudo sugere que o TLR4 tem um papel importante na interligação entre o sistema imune inato e a resistência à insulina, sendo um possível alvo terapêutico para a obesidade, resistência à insulina e diabetes mellitus tipo 2
Abstract: Obesity is associated with insulin resistance and a state of abnormal inflammatory response. The Toll-like receptor 4 (TLR4) has an important role in inflammation and immunity and its expression has been reported in most tissues of the body, including the insulin-sensitive ones. Since it is activated by lipopolysaccharide (LPS) and saturated fatty acids, which are inducers of insulin resistance, TLR4 may be a candidate for participation in the cross-talk between inflammatory and metabolic signals. Here, we show that C3H/HeJ mice, which have a loss-of-function mutation in TLR4, are protected against the development of diet-induced obesity. In addition, these mice demonstrate decreased adiposity, increased oxygen consumption, a decreased respiratory exchange ratio, improved insulin sensitivity and enhanced insulin signaling capacity in adipose tissue, muscle and liver, as compared to control mice during high fat feeding. Moreover, in these tissues, control mice fed on a high fat diet show an increase in IKKß and JNK activity, which is prevented in C3H/HeJ mice. In isolated muscles from C3H/HeJ a protection from saturated fatty acid-induced insulin resistance is observed. Thus, TLR4 appears to be an important mediator of obesity and insulin resistance and a potential target for the therapy of these highly prevalent medical conditions
Doutorado
Ciencia Basica
Doutor em Clínica Médica
Harne, Amanda Janel. "Influence of vitamin D receptor gene polymorphisms on changes in insulin sensitivity with aerobic exercise training." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2191.
Full textThesis research directed by: Dept. of Kinesiology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Mardilovich, Katerina. "Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/533.
Full textJain, Reema. "When too much sun is never enough: Association of the VDR gene polymorphisms with insulin resistance." AUT University, 2010. http://hdl.handle.net/10292/990.
Full textIggström, Sofia. "Investigation of the role of insulin receptor genes in wing polyphenism using gene knockdown and differential gene expression analysis in the non-model organism Gerris buenoi." Thesis, Uppsala universitet, Institutionen för ekologi och genetik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-394909.
Full textGautam, Dinesh Chandra. "Analysis of insulin receptor function in the central nervous system by conditional inactivation of its gene in mice." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96492353X.
Full textRamaswamy, Girish. "Mechanical and geometric characterization of mouse cortical bone with osteoblast-specific knockout of insulin-like growth factor receptor gene." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/ramaswamy.pdf.
Full textBooks on the topic "Insulin receptor gene"
Petrisor, Bradley Allan. Analysis of the insulin receptor-related gene promoter. Ottawa: National Library of Canada, 1994.
Find full textJørn, Nerup, Mandrup-Poulsen Thomas, and Hökfelt Bernt, eds. Genes and gene products in the development of diabetes mellitus: Basic and clinical aspects : proceedings of the 3rd Nordisk Insulin Symposium "Genes and Gene Products in the Development of Diabetes Mellitus", Oslo, Norway, 3-5 July 1989. Amsterdam: Excerpta Medica, 1989.
Find full textC, Baxter R., Gluckman Peter D, and Rosenfeld Ron G, eds. The insulin-like growth factors and their regulatory proteins: Proceedings of the Third International Symposium on Insulin-Like Growth Factors, Sydney, 6-10 February 1994. Amsterdam: Excerpta Medica, 1994.
Find full textShier, Peter. Characterization of the gene encoding the insulin receptor-related receptor, IRR : a putative receptor for a member of the insulin family. 1992.
Find full textGenes and Gene Products in the Development of Diabetes Mellitus (Nordisk insulin symposia). Elsevier, 1989.
Find full textBaxter, R. C., and Peter D. Gluckman. The Insulin-Like Growth Factors and Their Regulatory Proteins: Proceedings of the Third International Symposium on Insulin-Like Growth Factors, Sydn (International Congress Series). Elsevier Science Pub Co, 1994.
Find full textBook chapters on the topic "Insulin receptor gene"
McKeon, Catherine. "Transcriptional Regulation of the Insulin Receptor Gene Promoter." In Advances in Experimental Medicine and Biology, 79–89. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2988-0_9.
Full textGranner, D., D. Chu, C. Davis, and N. Chrapkiewicz. "Recriprocal Regulation of Pepck Gene and Gene 33 Transcription by Insulin." In The Steroid/Thyroid Hormone Receptor Family and Gene Regulation, 195–206. Basel: Birkhäuser Basel, 1989. http://dx.doi.org/10.1007/978-3-0348-5466-5_14.
Full textTrembath, R. C., S. Li, and D. J. Galton. "DNA Polymorphisms of the Insulin Receptor Gene and Non-Insulin-Dependent Diabetes Mellitus." In Verhandlungen der Deutschen Gesellschaft für Innere Medizin, 495–98. Munich: J.F. Bergmann-Verlag, 1987. http://dx.doi.org/10.1007/978-3-642-85460-6_124.
Full textTaylor, Simeon I., Domenico Accili, Alessandro Cama, Hiroko Kadowaki, Takashi Kadowaki, Eiichi Imano, and Maria de la Luz Sierra. "Mutations in the Insulin Receptor Gene in Patients with Genetic Syndromes of Insulin Resistance." In Advances in Experimental Medicine and Biology, 197–213. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5949-4_19.
Full textWerner, Haim, Bethel Stannard, Mark A. Bach, Charles T. Roberts, and Derek LeRoith. "Regulation of Insulin-Like Growth Factor I Receptor Gene Expression in Normal and Pathological States." In Advances in Experimental Medicine and Biology, 263–72. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5949-4_24.
Full textBauskin, A. R., M. Zion, J. Szpirer, C. Szpirer, M. Q. Islam, G. Levan, G. Klein, and Y. Ben-Neriah. "Expression and Chromosomal Assignment of a Novel Protein-Tyrosine Kinase Gene Related to the Insulin Receptor Family." In Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, 453–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74621-5_79.
Full textLemamy, Guy Joseph, Majida Esslimani Sahla, Marie Laurence Berthe, and Pascal Roger. "Is the Mannose-6-Phosphate/Insulin-Like Growth Factor 2 Receptor Coded by a Breast Cancer Suppressor Gene?" In Hormonal Carcinogenesis V, 305–10. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-69080-3_28.
Full textLuthman, Holger, Ingrid Delin, Anna Glaser, Rolf Luft, Svante Norgren, and Anna Wedell. "Molecular Genetics of NIDDM and the Genes for Insulin and Insulin Receptor." In Advances in Experimental Medicine and Biology, 101–11. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2910-1_8.
Full textRosen, Kenneth M., Bruce M. Wentworth, Edward D. Lamperti, Stanislaus Kinota, Richard O’Brien, Nadia Rosenthal, Bruce Yankner, and Lydia Villa-Komaroff. "Expression of the IGF-II Gene in Brain and Muscle." In Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors, 219–29. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5685-1_19.
Full textMurphy, Liam J., and Henry G. Friesen. "Regulation of Insulin-Like Growth Factor-1 Gene Expression by Estrogen." In Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors, 153–68. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5685-1_14.
Full textConference papers on the topic "Insulin receptor gene"
Ahmed, Sumaya, and Nasser Rizk. "The Expression of Bile Acid Receptor TGR5 in Adipose Tissue in Diet-Induced Obese Mice." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0212.
Full textIhle, Kate E. "Insulin receptor substrate (IRS) gene knockdown impacts complex behavior and shortens lifespan in honey bee workers." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.115016.
Full textZhao, Ronghua, Ron Geyer, John Decoteau, and Alan Casson. "Abstract A9: Expression of insulin-like growth factor II and of the type 1 receptor gene in esophageal adenocarcinoma." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-a9.
Full textPotter, A., A. Potter, A. Casa, A. Casa, A. Lee, and A. Lee. "Gene Targets of Insulin-Like Growth Factor-I Receptor (IGF-IR) Signaling and Their Potential Role in Breast Cancer." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-4167.
Full textSparano, J., R. Gray, L. Goldstein, B. Childs, D. Brassard, R. Bugarini, S. Rowley, et al. "Gene Expression Profiling of Phenotypically-Defined Hormone-Receptor Positive Breast Cancer: Evidence for Increased Transcriptional Activity of the Insulin Growth Factor Receptor Pathway and Other Pathways." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-5165.
Full textKim, Mi Kyung, Han-Sung Kang, Sei Hyun Ahn, Kyeong-Man Hong, Siddhartha Kumar Mishra, Kyung Hwan Shin, Jungsil Ro, Keun Seok Lee, and Seok Won Kim. "Abstract 2610: Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with breast cancer in Korean women." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2610.
Full textDiniz, Ornella Moreira. "NUTRIGENÔMICA NA OBESIDADE E NO DIABETES MELLITUS TIPO (DM) II." In I SIMPÓSIO MARANHENSE DE GENÉTICA E GENÔMICA EM SAÚDE. Doity - Plataforma de Eventos, 2022. http://dx.doi.org/10.55664/simaggens2022.018.
Full textCruz, Ana Caroline Mesquita, and Mayana Aguiar Vasconcelos. "ACOMPANHAMENTO NUTRICIONAL EM MULHERES COM SÍNDROME DOS OVÁRIOS POLICÍSTICOS - UMA REVISÃO BIBLIOGRÁFICA." In I Congresso Brasileiro de Saúde Pública On-line: Uma abordagem Multiprofissional. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2817.
Full textResende, Ana Flávia Morais, Guilherme Rabelo Nasuk, Bruna Calixto de Jesus, Allan Luis Barboza Atum, and José Antônio Silva Júnior. "EXPRESSÃO MIOCÁRDICA RELACIONADA À CINÉTICA DO CÁLCIO EM ANIMAIS COM EXPOSIÇÃO PRÉ-NATAL AO ÁLCOOL." In Congresso Médico Acadêmico da Universidade Nove de Julho. Universidade Nove de Julho, 2022. http://dx.doi.org/10.5585/comamedvg.2022.16.
Full textReports on the topic "Insulin receptor gene"
Barash, Itamar, and Robert Rhoads. Translational Mechanisms Governing Milk Protein Levels and Composition. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696526.bard.
Full textHansen, Peter J., and Amir Arav. Embryo transfer as a tool for improving fertility of heat-stressed dairy cattle. United States Department of Agriculture, September 2007. http://dx.doi.org/10.32747/2007.7587730.bard.
Full textMeidan, Rina, and Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, March 1995. http://dx.doi.org/10.32747/1995.7604935.bard.
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