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1

Khan, Afreen, Anu Chandra, Abbas Ali Mahdi, and S. N. Sankhwar. "PROSTATE CANCER AND DIABETES LINK: ROLE OF INSULIN AND INSULIN LIKE GROWTH FACTORS." Era's Journal of Medical Research 6, no. 2 (December 2019): 147–51. http://dx.doi.org/10.24041/ejmr2019.145.

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2

Le Roith, Derek. "Insulin-Like Growth Factors." New England Journal of Medicine 336, no. 9 (February 27, 1997): 633–40. http://dx.doi.org/10.1056/nejm199702273360907.

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3

LeROITH, DEREK, and CHARLES T. ROBERTS. "Insulin-like Growth Factors." Annals of the New York Academy of Sciences 692, no. 1 The Role of I (August 1993): 1–9. http://dx.doi.org/10.1111/j.1749-6632.1993.tb26200.x.

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4

Schmid, C. "Insulin-like growth factors." Cell Biology International 19, no. 5 (May 1995): 445–58. http://dx.doi.org/10.1006/cbir.1995.1088.

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5

LeRoith, Derek, Michelle McGuinness, Joshua Shemer, Bethel Stannard, Fabienne Lanau, Teresa N. Faria, Hisanori Kato, Haim Werner, Martin Adamo, and Charles T. Roberts, Jr. "Insulin-Like Growth Factors." Neurosignals 1, no. 4 (1992): 173–81. http://dx.doi.org/10.1159/000109323.

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6

McIntyre, Roger S., Dragana Vagic, Shari A. Swartz, Joanna K. Soczynska, Hanna O. Woldeyohannes, Lakshmi P. Voruganti, and Jakub Z. Konarski. "Insulin, Insulin-Like Growth Factors??and Incretins." CNS Drugs 22, no. 6 (2008): 443–53. http://dx.doi.org/10.2165/00023210-200822060-00001.

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7

Pollak, Michael. "Insulin, insulin-like growth factors and neoplasia." Best Practice & Research Clinical Endocrinology & Metabolism 22, no. 4 (August 2008): 625–38. http://dx.doi.org/10.1016/j.beem.2008.08.004.

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8

Pollak, Michael N. "Insulin, insulin-like growth factors, insulin resistance, and neoplasia." American Journal of Clinical Nutrition 86, no. 3 (September 1, 2007): 820S—822S. http://dx.doi.org/10.1093/ajcn/86.3.820s.

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9

Purwana, Arie, Budiono Budiono, Jose RL Batubara, and Muhammad Faizi. "Association of Growth Velocity with Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Children with a Vegan Diet." Journal of Biomedicine and Translational Research 6, no. 1 (February 6, 2020): 6–10. http://dx.doi.org/10.14710/jbtr.v6i1.5474.

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Background: The vegan diet in children provides the benefit of reducing the risk of being overweight and improving the fat profile. The risk that can occur in the provision of a vegan diet in children is anthropometric size below reference and low caloric intake. Growth hormone (GH) and Insulin like Growth Factors (IGFs) are powerful stimulators for longitudinal growth of bone and require insulin-like growth factor binding protein (IGFBPs) which acts as a transport protein for IGF-1. A vegan diet with lower calorie intake in children has lower IGF-I levels than children with an omnivorous diet.Objective: Examining the effect of vegan diets on IGF-1 levels, IGFBP-3 levels, and growth velocity.Methods: This study was done with a prospective cohort design. The study subjects were divided into two groups, namely the vegan group and the omnivorous group, then matched based on age and sex. During the study, anthropometric data collection, IGF-1 and IGFBP-3 levels measurements were done in both vegan children and omnivorous children.Results: During 6 months of observation, 22 subjects were divided into two groups, namely children with a vegan diet and children with an omnivorous diet. IGF-1 (ng / mL) in vegan children was 105.5 ± 47.3 compared to 102.7 ± 42.3 in omnivorous children with a value of p = 0.89. IGFBP-3 (ng / mL) in vegan children was 2146.4 ± 595.1 compared to 2142 ± 609.1 in omnivorous children with value of p = 0.99 and Growth Velocity (cm / 6 months) was 3.0 in vegan children (1.0-5.30), and 3.2 (2.6-6.5) in omnivorous children with value of p = 0.41.Conclusion:Children with vegan diet had IGF-1 level, IGFBP-3 level, and growth velocity that were the same as children with an omnivorous diet.
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10

Gunnell, D., and J. M. P. Holly. "Insulin-like growth factors, insulin resistance and schizophrenia." British Journal of Psychiatry 185, no. 4 (October 2004): 353–54. http://dx.doi.org/10.1192/bjp.185.4.353-a.

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11

Froesch, E. R., and J. Zapf. "Insulin-like growth factors and insulin: comparative aspects." Diabetologia 28, no. 8 (August 1985): 485–93. http://dx.doi.org/10.1007/bf00281982.

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12

Bar, Robert S., Mary Boes, Brian L. Dake, Barbara A. Booth, Sherry A. Henley, and Alexander Sandra. "Insulin, insulin-like growth factors, and vascular endothelium." American Journal of Medicine 85, no. 5 (November 1988): 59–70. http://dx.doi.org/10.1016/0002-9343(88)90398-1.

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13

Poretsky, Leonid. "Ovarian Insulin-like Growth Factors." Annals of Internal Medicine 117, no. 6 (September 15, 1992): 535. http://dx.doi.org/10.7326/0003-4819-117-6-535_1.

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14

Cohick, W. S., and D. R. Clemmons. "The Insulin-Like Growth Factors." Annual Review of Physiology 55, no. 1 (October 1993): 131–53. http://dx.doi.org/10.1146/annurev.ph.55.030193.001023.

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15

Yokoyama, Shunichi, Lucia Stefaneanu, and Kalman Kovacs. "Pituitary insulin-like growth factors." Endocrine Pathology 8, no. 3 (September 1997): 167–79. http://dx.doi.org/10.1007/bf02738783.

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16

Dunger, D. B. "Insulin and insulin-like growth factors in diabetes mellitus." Archives of Disease in Childhood 72, no. 6 (June 1, 1995): 469–71. http://dx.doi.org/10.1136/adc.72.6.469.

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17

Baskin, Denis G., Barbara J. Wilcox, Dianne P. Figlewicz, and Daniel M. Dorsa. "Insulin and insulin-like growth factors in the CNS." Trends in Neurosciences 11, no. 3 (January 1988): 107–11. http://dx.doi.org/10.1016/0166-2236(88)90155-5.

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18

LeRoith, Derek. "Insulin-like Growth Factors and Cancer." Annals of Internal Medicine 122, no. 1 (January 1, 1995): 54. http://dx.doi.org/10.7326/0003-4819-122-1-199501010-00009.

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19

Hammerman, Marc R. "Insulin-Like Growth Factors and Aging." Endocrinology and Metabolism Clinics of North America 16, no. 4 (December 1987): 995–1011. http://dx.doi.org/10.1016/s0889-8529(18)30455-9.

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20

Rutanen, Eeva-Marja. "Insulin-like growth factors in obstetrics." Current Opinion in Obstetrics and Gynecology 12, no. 3 (June 2000): 163–68. http://dx.doi.org/10.1097/00001703-200006000-00001.

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21

Canalis, E. "Insulin-like growth factors and osteoporosis." Bone 21, no. 3 (September 1997): 215–16. http://dx.doi.org/10.1016/s8756-3282(97)00150-6.

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22

McMurtry, J. P., G. L. Francis, and Z. Upton. "Insulin-like growth factors in poultry." Domestic Animal Endocrinology 14, no. 4 (July 1997): 199–229. http://dx.doi.org/10.1016/s0739-7240(97)00019-2.

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23

SMITH, U., J. ERIKSSON, and P. LöNNROTH. "Receptors for insulin-like growth factors." Journal of Internal Medicine 225, no. 1 (January 1989): 43–45. http://dx.doi.org/10.1111/j.1365-2796.1989.tb00035.x.

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24

HALL, K., and M. TALLY. "The somatomedin-insulin-like growth factors." Journal of Internal Medicine 225, no. 1 (January 1989): 47–54. http://dx.doi.org/10.1111/j.1365-2796.1989.tb00036.x.

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25

Froesch, E. R., C. Schmid, J. Schwander, and J. Zapf. "Actions of Insulin-Like Growth Factors." Annual Review of Physiology 47, no. 1 (October 1985): 443–67. http://dx.doi.org/10.1146/annurev.ph.47.030185.002303.

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26

Fürstenberger, Gregor, and Hans-Jörg Senn. "Insulin-like growth factors and cancer." Lancet Oncology 3, no. 5 (May 2002): 298–302. http://dx.doi.org/10.1016/s1470-2045(02)00731-3.

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27

Bach, Leon A., and Matthew M. Rechler. "Insulin-like growth factors and diabetes." Diabetes / Metabolism Reviews 8, no. 3 (October 1992): 229–57. http://dx.doi.org/10.1002/dmr.5610080304.

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28

Merimee, Thomas J., Jurgen Zapf, Barry Hewlett, and L. L. Cavalli-Sforza. "Insulin-like Growth Factors in Pygmies." New England Journal of Medicine 316, no. 15 (April 9, 1987): 906–11. http://dx.doi.org/10.1056/nejm198704093161503.

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29

Macaulay, VM. "Insulin-like growth factors and cancer." British Journal of Cancer 65, no. 3 (March 1992): 311–20. http://dx.doi.org/10.1038/bjc.1992.65.

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30

Pollak, Michael N., Eva S. Schernhammer, and Susan E. Hankinson. "Insulin-like growth factors and neoplasia." Nature Reviews Cancer 4, no. 7 (July 2004): 505–18. http://dx.doi.org/10.1038/nrc1387.

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31

Merimee, Thomas J. "Special issue: Insulin-like Growth Factors." Regulatory Peptides 48, no. 1-2 (October 1993): vii. http://dx.doi.org/10.1016/0167-0115(93)90329-7.

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32

Gu, Lijuan, Eun-Kyoung Mo, ZheMing Fang, BaiShen Sun, XueMei Zhu, and Chang-Keun Sung. "Partial Purification and Quantification of Insulin-like Growth Factor-I from Red Deer Antler." Journal of Life Science 17, no. 10 (October 30, 2007): 1321–29. http://dx.doi.org/10.5352/jls.2007.17.10.1321.

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33

Rosen, Clifford J. "Serum Insulin-like Growth Factors and Insulin-like Growth Factor-binding Proteins: Clinical Implications." Clinical Chemistry 45, no. 8 (August 1, 1999): 1384–90. http://dx.doi.org/10.1093/clinchem/45.8.1384.

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Abstract The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated, and subcellular signaling mechanisms have been clarified. Clearly, both tissue and circulating growth factor concentrations are important in defining the relationship between IGF-I and cell activity. Bone, liver, and circulatory IGF-I have received the most attention by investigators, in part because of the ease of measurement and the interaction with disease states such as osteoporosis. More recently, attention has focused on the role IGF-I plays in neoplastic transformation and growth. Two large prospective observational studies have demonstrated greater risk for prostate and breast cancer associated with high circulating concentrations of IGF-I. Animal models and in vitro studies confirm that there is a close, albeit complex, interaction between IGF-I signaling and bone turnover. This report will focus on: (a) IGF physiology, including IGF ligands, binding proteins, and proteases; (b) the relationship between IGF-I and bone mass in respect to risk for osteoporosis; (c) the heritable regulation of the IGF-I phenotype; and (d) the association between serum IGF-I and cancer risk. The IGFs remain a major area for basic and clinical investigations; future studies may define both diagnostic and therapeutic roles for these peptides or their related proteins in several disease states.
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34

Cara, José F. "Insulin-Like Growth Factors, Insulin-Like Growth Factor Binding Proteins and Ovarian Androgen Production." Hormone Research 42, no. 1-2 (1994): 49–54. http://dx.doi.org/10.1159/000184145.

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35

Kostecká, Z., and J. Blahovec. "Animal insulin-like growth factor binding proteins and their biological functions." Veterinární Medicína 47, No. 2 - 3 (March 30, 2012): 75–84. http://dx.doi.org/10.17221/5807-vetmed.

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Insulin-like growth factor (IGF-I, IGF-II) action is influenced by until today known eight forms of insulin-like growth factor binding proteins (IGFBPs). They have been obtained not only from some human and animal tissues and body fluids but also from conditioned medium of cell cultures. An important biological property of the IGFBPs is their ability to increase the circulating half-life of the IGFs. They are able to act as potentiators of cell proliferation. As IGFBPs bind to cell surfaces, they may act either to deliver the IGFs to those surfaces for activation of specific receptors or to activate cell responses independently of receptor activation. Phosphorylation, glycosylation and proteolysis of IGFBPs influence their affinity to IGFs. The IGFBPs in the role of inhibitors may block the activity of the IGFs and be used for antimitogenic therapy. In the last time measuring of IGFBPs levels can be used for diagnosis determination of some endocrine diseases or in differential diagnostics.
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36

Denko, C. W., and B. Boja. "Growth factors in asymptomatic osteoarthritis - insulin, insulin-like growth factor-1, growth hormone." Inflammopharmacology 2, no. 1 (March 1993): 71–76. http://dx.doi.org/10.1007/bf02663743.

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37

Bajpai, Anurag, and P. S. N. Menon. "Insulin like growth factors axis and growth disorders." Indian Journal of Pediatrics 73, no. 1 (January 2006): 67–71. http://dx.doi.org/10.1007/bf02758264.

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38

Kim, Hye Jin, and Won Jun Lee. "Insulin-like Growth Factor-I Induces FATP1 Expression in C2C12 Myotubes." Journal of Life Science 24, no. 12 (December 30, 2014): 1284–90. http://dx.doi.org/10.5352/jls.2014.24.12.1284.

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39

Gabbitas, Bari, and Ernesto Canalis. "Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts." American Journal of Physiology-Endocrinology and Metabolism 275, no. 2 (August 1, 1998): E222—E228. http://dx.doi.org/10.1152/ajpendo.1998.275.2.e222.

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Insulin-like growth factors (IGFs) I and II are considered to be autocrine regulators of bone cell function. Recently, we demonstrated that IGF-I induces IGF-binding protein-5 (IGFBP-5) expression in cultures of osteoblast-enriched cells from 22-day fetal rat calvariae (Ob cells). In the present study, we postulated that IGFs play an autocrine role in the maintenance of IGFBP-5 basal expression in Ob cells. IGFBP-2 and -3, at concentrations that bind endogenous IGFs, decreased IGFBP-5 mRNA levels, as determined by Northern blot analysis, and protein levels, as determined by Western immunoblots of extracellular matrix extracts of Ob cells. IGFBP-2 and -3 in excess inhibited IGFBP-5 heterogeneous nuclear RNA levels, as determined by RT-PCR, and did not alter the half-life of IGFBP-5 mRNA in transcriptionally arrested Ob cells. In conclusion, blocking endogenous IGFs in Ob cells represses IGFBP-5 expression, suggesting that IGFs are autocrine inducers of IGFBP-5 synthesis in osteoblasts.
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40

King, Jeffery L., and Clyde Guidry. "Insulin-Like Growth Factor Binding Proteins Modulate Müller Cell Responses to Insulin-Like Growth Factors." Investigative Opthalmology & Visual Science 45, no. 8 (August 1, 2004): 2848. http://dx.doi.org/10.1167/iovs.04-0054.

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41

HASEGAWA, TOMONOBU, YUKIHIRO HASEGAWA, MAKOTO TAKADA, FUMIHIKO KURIMOTO, and YUTAKA TSUCHIYA. "Insulin-Like Growth Factors-Insulin-Like Growth Factor Binding Protein Axis and Diabetic Cotrol in Insulin- Dependent Diabetes Mellitus." Endocrine Journal 45, Suppl (1998): S129—S131. http://dx.doi.org/10.1507/endocrj.45.suppl_s129.

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42

Shimon, Ilan. "Insulin-Like Growth Factors and Hematologic Malignancies." Annals of Internal Medicine 123, no. 1 (July 1, 1995): 76. http://dx.doi.org/10.7326/0003-4819-123-1-199507010-00020.

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43

Rutanen, E. M. "Insulin-like growth factors in endometrial function." Gynecological Endocrinology 12, no. 6 (January 1998): 399–406. http://dx.doi.org/10.3109/09513599809012842.

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44

Helle, Svein I., and Per E. Lønning. "Insulin-Like Growth Factors in Breast Cancer." Acta Oncologica 35, sup5 (January 1996): 19–22. http://dx.doi.org/10.3109/02841869609083963.

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45

Gazzerro, Elisabetta, and Ernesto Canalis. "Skeletal actions of insulin-like growth factors." Expert Review of Endocrinology & Metabolism 1, no. 1 (January 2006): 47–56. http://dx.doi.org/10.1586/17446651.1.1.47.

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46

Havemann, Klaus, and Gabriele Jaques. "Insulin-like growth factors in lung cancer." Lung Cancer 18 (August 1997): 9. http://dx.doi.org/10.1016/s0169-5002(97)83859-7.

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47

SCHLABRITZ-LOUTSEVITCH, NATALIA, CUN LI, and PETER W. NATHANIELSZ. "INSULIN-LIKE GROWTH FACTORS AND PLACENTAL FUNCTION." Fetal and Maternal Medicine Review 18, no. 3 (August 2007): 201–24. http://dx.doi.org/10.1017/s0965539507001994.

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Placentas from different species differ not only in their cellular structure and normal trajectory of growth but also in the architecture of their placental vasculature and the transport and exchange mechanisms that determine nutritional transfer from mother to fetus and waste disposal from fetus to mother.1 Many maternal and fetal hormonal and nutritional factors, as well as placental paracrine and autocrine systems affect placental growth and development throughout gestation.2 Nutrients delivered from the maternal circulation are as important for placental growth as they are for fetal growth. In addition to passing across the placenta to provide the building blocks for fetal growth, amino acids, carbohydrate and lipids are incorporated into the placenta.
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48

Herington, Adrian C. "Insulin-like growth factors: biochemistry and physiology." Baillière's Clinical Endocrinology and Metabolism 5, no. 4 (December 1991): 531–51. http://dx.doi.org/10.1016/s0950-351x(10)80002-3.

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49

HUMBEL, Rene E. "Insulin-like growth factors I and II." European Journal of Biochemistry 190, no. 3 (June 1990): 445–62. http://dx.doi.org/10.1111/j.1432-1033.1990.tb15595.x.

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50

Byrne, Celia, Susan E. Hankinson, Michael Pollak, Walter C. Willett, Graham A. Colditz, and Frank E. Speizer. "Insulin-like growth factors and mammographic density." Growth Hormone & IGF Research 10 (January 2000): S24—S25. http://dx.doi.org/10.1016/s1096-6374(00)90011-x.

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