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Dissertations / Theses on the topic 'Insulin analogue'

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Published: 9 March 2023

Last updated: 31 July 2025

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1

Elamin, Ahmed Abu Baker. "Studies on the short-acting insulin analogue lispro." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310125.

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2

PEROTTI, MARIO. "EFFICACIA DEL PASSAGGIO A DEGLUDEC DA UN’ALTRA INSULINA BASALE (GLARGINE/ DETEMIR) IN UNA COORTE DI PAZIENTI CON DIABETE MELLITO TIPO 1 ( DMT1) IN CONDIZIONI DI REALE PRATICA CLINICA." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241121.

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La terapia del diabete tipo 1 può oggi essere più flessibile e personalizzata grazie alla disponibilità di numerosi tipi di insulina che differiscono tra loro per la farmacocinetica (inizio, picco e durata di azione). Il miglior controllo glicometabolico può essere ottenuto attraverso una terapia multiniettiva secondo uno schema basal-bolus, il quale prevede 3 somministrazioni preprandiali di un analogo rapido, che esprime meglio la fisiologica secrezione insulinica determinata dai pasti e da 1 iniezione di insulina ad azione lenta, necessaria per risponde

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3

Louafi, Fethi. "Role of retinoic acid or vitamin D analogue in models of human keratinocyte apoptosis : interactions with the IGF system." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269235.

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4

Moolman, Lukas Johannes. "The effect of snacking on continuously monitored glucose concentrations in analogue insulin basal bolus treatment regimens." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40694.

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5

Gagnon-Auger, Maude. "Améliorer la pharmacocinétique de l’insuline analogue ultrarapide chez des sujets obèses et diabétiques de type 2." Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/11616.

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Résumé: Comparées aux classiques insulines humaines régulières (IHR), les insulines analogues ultrarapides (IAUR) ont été conçues pour mieux synchroniser le pic insulinémique avec l’absorption du repas. Le progrès a été démontré chez les patients diabétiques de type 1, mais le contrôle glycémique s’est peu ou pas amélioré chez les patients diabétiques de type 2 (DT2), qu’ils soient sous IAUR ou IHR. Or ces patients constituent 75 % des utilisateurs d’insuline. L’utilité des IAUR est donc toujours débattue. La dose (donc le volume) injectée et le flot sanguin dans le tissu adipeux sous-cutané (

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6

LEPERRE, ARMELLE. "Etude des effets de l'insulin-like growth factor i (igf-i, facteur analogue a l'insuline i) sur les fibroblastes en cultures monocouches et tridimensionnelles." Reims, 1992. http://www.theses.fr/1992REIMM037.

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7

Watson, Christopher John. "Insulin analogues for insulin receptor studies and medical applications." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/3797/.

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The structure of insulin molecule was determined by Dorothy Hodgkin in 1969. Subsequently, it has been established that insulin must rearrange upon binding to its receptor (Insulin Receptor – IR). However, all known structures of the hormone depict its storage or inactive form. It has been shown that some residues, key for IR binding, are buried inside the insulin molecule and must be exposed for an efficient insulin-IR complex formation. It has been postulated that the C-terminal region of the B-chain (~B20-B30) is dynamic in this process, and that the detachment of the B20-B30 β-strand leads

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8

Tian, Ailing. "IGF1 Receptor Inhibition Amplifies the Effects of Cancer Drugs by Autophagy and Immune-Dependent Mechanisms." Electronic Thesis or Diss., université Paris-Saclay, 2022. http://www.theses.fr/2022UPASL040.

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Un certain nombre de produits végétaux naturels induisent l'autophagie et interviennent sur la durée de vie et la durée de vie dépendantes de l'autophagie dans des modèles de souris appropriés. Ici, nous avons identifié la picropodophylline (PPP) comme un inducteur non toxique du flux autophagique qui agit sur les cellules humaines et de souris in vitro, ainsi que sur les organes de souris in vivo. Mécaniquement, PPP inhibe IGF1R ainsi qu'en aval d'AKT, la cible mécaniste du complexe de rapamycine 1 (mTORC1), couplé à l'activation des facteurs de transcription pro-autophagiques EB (TFEB) et E3

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9

Shojaee-Moradie, Fariba. "Hepatic and peripheral effects of four insulin analogues." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338643.

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10

Bagley, Christopher James. "Analogues of Insulin-Like Growth Factor-1 / Christopher James Bagley." Title page, table of contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09phb146.pdf.

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11

Milner, Steven John. "The oxidative folding of insulin-like growth factor-I analogues /." Title page, table of contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phm65945.pdf.

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12

Verchere, Cameron Bruce. "Control of insulin secretion from the perfused rat pancreas : effects of acetylcholine and a somatostatin analog, SMS 201-995." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26657.

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The effect of varying concentrations of glucose or the gastrointestinal hormones, gastric inhibitory polypeptide (GIP) and somatostatin (SS-14), on the in vitro immunoreactive insulin (IRI) response to the parasympathetic neurotransmitter, acetylcholine (ACh) was investigated. The isolated, vascularly perfused rat pancreas was used in all experiments. Acetylcholine (1.0 µM) did not stimulate IRI secretion in the presence of 2.2 mM glucose. However, in the presence of 4.4, 6.6, or 8.9 mM glucose, ACh (1.0 µM) potently stimulated IRI secretion (approximately fourfold). At a higher glucose conce

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13

Liu, Hui-Kang. "Modification of the function of insulin-secreting cells by beta-cell toxins, differentiation drugs, insulin mimetics, steroids, and incretic hormones and their stable analogues." Thesis, University of Ulster, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399055.

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14

Agin, Arnaud. "Dosage des analogues de l'insuline à l'aide de deux immunodosages de l'insuline humaine : Evaluation analytique et application à l'étude de la biotransformation de la glargine." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. https://publication-theses.unistra.fr/public/theses_doctorat/2006/AGIN_Arnaud_2006.pdf.

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15

Agin, Arnaud Sapin Rémy. "Dosage des analogues de l'insuline à l'aide de deux immunodosages de l'insuline humaine évaluation analytique et application à l'étude de la biotransformation de la glargine /." Strasbourg : Université Louis Pasteur, 2008. http://eprints-scd-ulp.u-strasbg.fr:8080/875/01/AGIN_Arnaud_2006.pdf.

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16

Marshall, Nicholas John. "The influence of insulin-like growth factor 1 and its analogues on fibroblasts and dermal wound healing." Title page, table of contents and synopsis only, 1998. http://web4.library.adelaide.edu.au/theses/09MD/09mdm3685.pdf.

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Includes bibliography (leaves 191-219). Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in vivo at the wound s

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17

Gagnon-Auger, Maude. "Réévaluation de la pharmacocinétique d'une insuline analogue ultrarapide chez des sujets obèses et diabétiques de type 2." Mémoire, Université de Sherbrooke, 2010. http://savoirs.usherbrooke.ca/handle/11143/4004.

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Les caractéristiques pharmacocinétiques des insulines analogues ultra-rapides (IAUR) furent établies chez des sujets de poids normal, sains ou diabétiques de type 1, et à partir de petites doses d'insuline (4-12 U). La taille de la dose injectée et le flot sanguin dans le tissu adipeux (FSTA) sont des facteurs très importants qui affectent l'absorption sous-cutanée de l'insuline. Cependant, chez les patients obèses et diabétiques de type 2 (DT2), les doses d'insulines injectées sont beaucoup plus importantes et leur FSTA de base est 50 à 70 % plus faible que chez un sujet sain de poids normal.

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18

Glidden, Michael D. II. "Single-chain insulin analogs as ultra-stable therapeutics and as models of protein (mis)folding: stability, structure, dynamics, and function of novel analogs." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522270994798884.

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19

Dong, Siyuan. "A time dependent adaptive learning process for estimating drug exposure from register data - applied to insulin and its analogues." Thesis, KTH, Beräkningsbiologi, CB, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128438.

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20

Hartmann, Thorsten [Verfasser], Jürgen [Akademischer Betreuer] Eckel, and Eckhard [Gutachter] Lammert. "Effect of long-acting insulin analogues on human cardiovascular cell models / Thorsten Hartmann ; Gutachter: Eckhard Lammert ; Betreuer: Jürgen Eckel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1136421882/34.

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21

Marsh, Andrew. "Characterisation of the type I IGF receptor binding surfaces of insulin-like growth factor 1 using protein engineering." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245705.

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22

Gajanandana, Oraprapai. "Studies of complexes formed in blood in vivo between an insulin-like growth factor analog and binding proteins." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phg145.pdf.

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Includes bibliographical references (43 leaves) This study shows that when LR3IGF-I is administered to animals in pharmacologically active doses, it may be present in either the free form or bound to IGF-binding protein(s) in the circulation. Age and nutrition which are factors that regulate synthesis of endogenous IGF-I and IGF-binding proteins, affect the in vivo formation of complexes between the analog and IGFBP(s). This study also suggests that IGFBP-1 inhibits the pharmacological activity of circulating LR3IGF-I on thymus whereas it appears to stimulate the pharmacological activity of LR

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23

Kornienko, Alexander. "Practical enantiospecific syntheses of differentially protected cyclitols and partial synthesis of a non-Hydrolyzable Phosphooligosaccharide analog related to insulin signal transduction /." Thesis, Connect to Dissertations & Theses @ Tufts University, 1999.

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Thesis (Ph.D.)--Tufts University, 1999.<br>Adviser: Marc d'Alarcao. Submitted to the Dept. of Chemistry. Includes bibliographical references (leaves 123-128). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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24

Hall, Melanie J. "Pharmacology of the GLP-1 Analog Liraglutide in Healthy Cats." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405949641.

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25

Gleizes, Céline. "Mécanismes et contrôle de la réaction inflammatoire précoce au cours de la greffe d'îlots pancréatiques dans un modèle de lignée de cellules bêta de rat : rôle et modulation de la libération des microparticules." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ082/document.

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La greffe d’îlots pancréatiques est caractérisée par une réponse inflammatoire et procoagulante précoce, connue sous le nom d’IBMIR (Instant Blood Mediated Inflammatory Reaction). Les microparticules (MPs) porteuses de facteur tissulaire (TF) sont le témoin d’un important remodelage membranaire et constituent des acteurs centraux dans la dissémination du stress de l’IBMIR. Nous avons exploré l’effet d’un stress inflammatoire sur la survie et la fonction de la cellule β dans un modèle de communication cellulaire médiée par les MPs. La modulation pharmacologique par les analogues du GLP-1 a été

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26

Duarte, Felipe Henning Gaia. "Síndrome da apnéia do sono na acromegalia: impacto do tratamento sobre o metabolismo dos carboidratos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-19092011-152108/.

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Introdução: A acromegalia é uma doença rara, caracterizada pela produção aumentada de hormônio do crescimento, causada geralmente por um adenoma hipofisário, ocasionando uma série de comorbidades como apneia do sono e resistência insulínica que acarretam um aumento na mortalidade e redução da expectativa de vida. Objetivo: O objetivo deste estudo foi avaliar o impacto da terapêutica da apneia do sono com um dispositivo de pressão positiva contínuas nas vias aéreas (CPAP) e avaliar o impacto desta terapêutica na resistência insulínica pela realização do clamp euglicêmico hiperinsulinêmico (CEH)

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27

Lord, Andrew P. D. "IGF transfer from blood to tissue: comparison of IGF-I with analogs that bind poorly to binding proteins, using a vascular perfusion model : a thesis submitted to the University of Adelaide, South Australia, for the degree of Doctor of Philosophy /." Title page, abstract and table of contents, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phl866.pdf.

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28

Jacob, Dolly. "Investigation into reliability and performance of an implantable closed-loop insulin delivery device." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/11126.

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An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied for future clinical use. Investigations into the device material compatibility with insulin solution, assessed by monitoring insulin loss and degradant formation over a period of 31 days using RP-HPLC have shown that stainless steel and titanium are the most compatible materials. Polycarbonate contribu

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29

Blanchetier, Valérie. "Insulino-résistance et insuffisance rénale chronique : intérêt d'un régime restreint en protides et en phosphore et supplémenté en acides aminés essentiels et céto-analogues." Bordeaux 2, 1995. http://www.theses.fr/1995BOR23086.

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30

Lin, Jen-Chieh, and 林人傑. "Association of Insulin Analogue and Antihypertensive Drug Use with Sight-Threatening Diabetic Retinopathy in Type 2 Diabetes." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/11074019666950049637.

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博士<br>國立臺灣大學<br>流行病學與預防醫學研究所<br>102<br>Objectives: The aims of the study are to estimate age- and sex-specific prevalence and incidence of sight-threatening diabetic retinopathy in Taiwan and evaluate the effect of systemic drugs on prevention of diabetic retinopathy progression, focusing on antihypertensive drugs and long-acting insulin analogues. Materials and Methods: Data was collected from a representative database, Longitudinal Health Insurance Database (LHID) 2005, during 2005, on a total of 222 incident cases of patients with sight-threatening diabetic retinopathy (STDR) among 29,165

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31

Kuan-YingLi and 李寬穎. "Comparative effectiveness and safety of intermediate-acting human insulin versus long-acting insulin analogue in patients with type 2 diabetes: A prevalent new-user cohort study." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/4tkwkz.

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碩士<br>國立成功大學<br>臨床藥學與藥物科技研究所<br>107<br>SUMMARY Basal insulin is recommended for the type 2 diabetes mellitus (T2DM) patients who need initial insulin therapy. However, there is not sufficient evidence about long-term vascular effects between basal insulin in T2DM population. This study was aimed to estimate the risks of macrovascular events, microvascular events, hospitalized hypoglycemia and all-cause mortality between intermediate-acting human insulin (IAHI) and long-acting insulin analogue (LAIA) users. Selection criteria of study population included newly diagnosed T2DM during 1999-2012 an

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32

Chrudinová, Martina. "Studium interakce inzulinu, IGF-1/2 a analogu IGF-1 s receptory inzulinu a IGF-1." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-336909.

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Insulin-like growth factors 1 and 2 (IGF-1/2) are single-chain peptides exerting homology (in both amino-acid sequence and tertiary structure) to insulin. The main function of these peptides is promoting celular growth, proliferation and differentiation. Both insulin and insulin-like growth factors mediate their function through membrane receptors - insulin receptor (isoforms A and B) and IGF-1 receptor. All these receptors are members of the tyrosinkinase family of receptors and they exert the same subunit and domain composition. The activation of insulin and IGF-1 receptors is tightly associ

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33

Kaplan, Vojtěch. "Nové analogy lidského insulinu s kovalentně stabilizovanými cyklickými strukturami v C-konci B-řetězce." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-313005.

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Diabetes mellitus is considered as one of world's most common metabolic diseases. Complicated treatment and increasing number of newly diagnosed patients, suffering from diabetes every year, shows the importance and necessity of research in this area. Some of the major aims of this research are the development of new therapeutically utilized drugs and defining the problems of insulin acting in human body. Insulin is a peptide hormone whose main physiological function is to regulate blood glucose level in organism connected with large impact on whole metabolism. Insulin acts through binding of

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34

Chrudinová, Martina. "Studium aktivačních vlastností analogů insulinu, IGF-1 a IGF-2 vůči receptorům pro insulin a IGF-1." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-397235.

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The insulin/insulin-like growth factor signaling axis is a complex system that is involved in the regulation of metabolism and body growth. It includes three related peptide hormones: insulin and two insulin-like growth factors (IGF-1 and IGF-2), and their receptors: two isoforms of insulin receptor (IR-A and IR-B), and IGF-1 receptor (IGF-1R). Whereas insulin is involved predominantly in regulation of the metabolism, IGFs participate mainly in the regulation of cell growth, proliferation and differentiation. Due to the similarities in the structures of both the hormones and the receptors, all

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35

Garnaut, Sonja Michelle. "The effect(s) of increasing intestinal mass with insulin-like growth factor-I peptides on nutrient absorption : a comparison of IGF-I and an analogue that binds poorly to binding proteins in normal rats using three methods to assess nutrient uptake / Sonja Michelle Garnaut." 2004. http://hdl.handle.net/2440/22233.

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Bibliography: leaves 193-236.<br>244 leaves : ill. (s. col.) ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics and Women's and Childrens Hospital, 2005

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Křížková, Květoslava. "Příprava a charakterizace selektivních analogů insulinu a IGF-2 pro různé isoformy insulinového receptoru." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-337324.

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Modern lifestyle with its lack of exercise and healthy diet often leads to obesity which is accompanied by a decreasing biological effect of insulin and the onset of hyperinsulinemia, and consequently type 2 diabetes. Persistently high levels of insulin stimulate signalling pathways with growth effects; cells thus become more sensitive to mitogenic effects of all growth factors which may even lead to the loss of control over cell proliferation and the rise of various malignancies. Due to a high degree of structure homology of insulin, IGF-I/II as well as particular IR (existing in "mitogenic"

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Kletvíková, Emília. "Syntéza a charakterizace nových analogů insulinu s cílem objasnit interakci insulinu s jeho receptorem." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-329261.

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The objective of this thesis is to characterize insulin analogues modified at the C-terminus of the B-chain with the aim to observe the impact of the inserted modifications on the insulin-insulin receptor (IR) interaction and the ability of the analogues to dimerize. Therefore, a series of analogues with modifications at B24-B26 positions was prepared. Using the synthetic and semisynthetic methods we inserted coded and non-coded amino acids to this part of B-chain. We studied full-length analogues and analogues truncated by three to four amino acids. Bindin

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Milner, Steven John. "The oxidative folding of insulin-like growth factor-I analogues / by Steven John Milner." Thesis, 1996. http://hdl.handle.net/2440/18702.

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Addendum pasted onto back end-paper.<br>Bibliography: leaves 146-179.<br>Bibliography: leaves 146-179.<br>ix, 179, [66] leaves, [2] leaves of plates : ill. (some col.) ; 30 cm.<br>This thesis investigates the effect of mutations and an N-terminal extension on the oxidative folding pathway of IGF-I, analyses the structure of the stable mis-folded molecule in terms of its biological interactions, examines the kinetics of the late stages of oxidative folding and finally attempts to dissect the folding pathway of a mutant of IGF-I.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry,

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Laajoki, Leanne G. "Nuclear magnetic resonance studies of insulin-like growth factor-I analogues displaying enhanced biological activity." Phd thesis, 2000. http://hdl.handle.net/1885/148063.

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Mlčochová, Květoslava. "Příprava a charakterizace selektivních analogů insulinu a IGF-2 pro obě isoformy insulinového receptoru a IGF-1 receptoru." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-411971.

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Insulin and insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) are related protein hormones with different but overlapping biological functions. All the hormones interact with a receptor within the insulin-IGF system (insulin receptor A and B, IGF-1 receptor), however with different affinity. The different interaction with individual receptors is just one of the main tools for regulation of the system that is essential for the proper functioning of the organism. Although the residues directly interacting with receptors are mainly located in A and B domains, the C and D domains probably play a

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Povalová, Anna. "Analogy insulinu s řetězcem A prodlouženým o doménu D proteinů IGF-1 a IGF-2." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-331976.

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Insulin and insulin-like growth factors (IGF-1 and -2) together with their receptors take part in a complex system, which affects both basal metabolism of carbohydrates, lipids and proteins as well as cell growth, proliferation, differentiation and apoptosis. Defects in action of insulin or IGFs can lead to serious diseases such as diabetes or cancer. Both of these disorders represent nowadays one of the biggest health threats to the world's population. Insulin and IGFs induce different biological effects through their cognate receptors; two isoforms of the insulin receptor (IR-A and IR-B) and

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Lieblich, Seth Aharon. "Non-Canonical Amino Acid Mutagenesis of Position B28 In Insulin with Proline Analogs." Thesis, 2017. https://thesis.library.caltech.edu/10166/7/Thesisv5.pdf.

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<p>Insulin is a protein hormone that is crucial for maintaining the concentration of blood glucose in vivo and is used clinically as a drug for the treatment of diabetes.</p> <p>Chapter I provides for an overview and background on the state of the art in insulin treatment of diabetes and the many attempts, over 95 years, to improve the pharmaceutically relevant properties of insulin and improve our understanding of the model globular protein.</p> <p>Chapter II demonstrates the incorporation of hydroxyproline analogs into insulin and shares the discovery of insulin with enhanced stabili

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Bryant, Katherine J. (Katherine Jane) 1962. "Design, production and characterisation of IGF-I analogues with increased gastric stability / by Katherine J. Bryant." Thesis, 1995. http://hdl.handle.net/2440/19074.

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Bibliography: leaves 112-140.<br>xi, 141, [39] leaves, [8] leaves of plates : ill. ; 30 cm.<br>The aims of this thesis are to determine the initial cleavage sites of purified pepsin in long-R3-IGF-I and assess whether the resulting cleavages affect biological activity, to design and produce analogues of long-R3-IGF-I which contain amino acid substitutions, to characterise the resulting analogues for pepsin resistance and retention of biological activity and to assess the stability of the long-R3-IGF-I analogues under in vivo conditions using luminal stomach flushings.<br>Thesis (Ph.D.)--Univer

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Bryant, Katherine J. (Katherine Jane) 1962. "Design, production and characterisation of IGF-I analogues with increased gastric stability / by Katherine J. Bryant." 1995. http://hdl.handle.net/2440/19074.

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Bibliography: leaves 112-140.<br>xi, 141, [39] leaves, [8] leaves of plates : ill. ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>The aims of this thesis are to determine the initial cleavage sites of purified pepsin in long-R3-IGF-I and assess whether the resulting cleavages affect biological activity, to design and produce analogues of long-R3-IGF-I which contain amino acid substitutions, to characterise the resulting analogues for pepsin resistance and retention of biological activity and to assess the stabi

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Hančlová, Ivona. "Nové zkrácené a nezkrácené analogy insulinu s modifikacemi v poloze B26." Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-370258.

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Marshall, Nicholas John. "The influence of insulin-like growth factor 1 and its analogues on fibroblasts and dermal wound healing." Thesis, 1998. http://hdl.handle.net/2440/38369.

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Includes bibliography (leaves 191-219).<br>x, 219 leaves<br>Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in

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Cottam, Jade Misty. "A study on the interactions of synthetic IGF-II analogues with the type 1 IGF and insulin receptors." Thesis, 2014. http://hdl.handle.net/2440/92810.

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Insulin-like growth factor II (IGF-II) is a unique regulatory peptide containing 67 residues and three disulfide bonds. It binds with high affinity to three receptors, the insulin receptor (IR), the type 1 insulin-like growth factor receptor (IGF-1R) and the We 2 insulin-like growth factor receptor (IGF-2R). Binding of IGF-II to these receptors signals mitogenic responses, such as cell proliferation, differentiation and migration. The interactions of IGF-II with the IR and IGF-1R have recently been identified as potential therapeutic targets for the treatment of cancer. Thus, an increased unde

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Macháčková, Kateřina. "Analogy IGF-1 pro studium interakce tohoto hormonu s receptory pro IGF-1 a insulin." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-389624.

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Insulin/IGF system is a complex network of three similar hormones (insulin, IGF-1 and IGF-2) and their three similar receptors (IR-A, IR-B and IGF-1R,), which play important roles in maintaining basal energy homeostasis of the organism, in growth, development, life-span but also in development of diseases such as diabetes mellitus, cancer, acromegaly or Laron dwarfism. Despite structural similarities between family members, each member have its unique role in the system. Identification of structural determinants in insulin and IGFs that trigger their specific signalling pathways is important f

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DONG, SIYUAN. "A time dependent adaptive learning process for estimating drug exposure from register data - applied to insulin and its analogues." Thesis, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-124386.

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Gajanandana, Oraprapai. "Studies of complexes formed in blood in vivo between an insulin-like growth factor analog and binding proteins / by Oraprapai Gajanandana." Thesis, 1997. http://hdl.handle.net/2440/19153.

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Includes bibliographical references (43 leaves)<br>xxiii, [216] leaves : ill. ; 30 cm.<br>This study shows that when LR3IGF-I is administered to animals in pharmacologically active doses, it may be present in either the free form or bound to IGF-binding protein(s) in the circulation. Age and nutrition which are factors that regulate synthesis of endogenous IGF-I and IGF-binding proteins, affect the in vivo formation of complexes between the analog and IGFBP(s). This study also suggests that IGFBP-1 inhibits the pharmacological activity of circulating LR3IGF-I on thymus whereas it appears to st

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