Dissertations / Theses on the topic 'Insular State'
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Brito, José Luís do Livramento Monteiro Alves de. "As privatizações num país pequeno, insular e arquipelágico : o caso de Cabo Verde." Master's thesis, Instituto Superior de Economia e Gestão, 2002. http://hdl.handle.net/10400.5/3397.
Full textA investigação visou, passados dez anos, uma avaliação técnica das privatizações em Cabo Verde no sentido de, através de respostas a várias questões, nomeadamente, sobre i) o seu papel na opção estratégica de desenvolvimento do país e a coerência com os objectivos, modefo, programa, ritmo e processo adoptados, ii) a evolução das empresas privatizadas em termos da performance económico - financeira e iii) o impacto dessa evolução na macroeconomia e competitividade do País, se formular uma tese sobre "As privatizações num País pequeno, insular e arquipelágico: o caso de Cabo Verde ". Nesse âmbito, o trabalho apresenta uma parte dedicada às questões de natureza teórica e análise da literatura e outra para as questões de natureza aplicada. Mais especificamente, para cumprir com a formulação do problema, desenvolveu-se, em termos teóricos, i) a análise conceptual prevalecente na dinâmica das privatizações a nível internacional , questionando as diversas lógicas e fins, ii) a revisão da literatura sobre o desempenho económico - financeiro das empresas privatizadas e em tenvos aplicados, iii) a mensuracão dos resultados das privatizações a nível do desenvolvimento económico - social de Cabo Verde, iv) a avaliação dos resultados também a nível das empresas privatizadas para, a partir daí, v) tirar as conclusões, tomando três referências de comparação, a situação da empresa antes da respectiva privatização, estudos da Price Waterhouse sobre as empresas públicas cabo-verdianas antes das Privatizações e estudos internacionais sobre empresas privatizadas. O estudo empírico baseou - se numa amostra de 11 empresas privatizadas entre 1993 e 1999 e conclui que, apesar do pouco tempo decorrido, há evidências claras de i) uma redução significativa do peso do Estado na economia, ii) uma contribuição muito positiva para os indicadores macroeconómicos do país e iii) melhorias significativas no pós - privatização dos indicadores de rendibilidade, eficiência operativa, vendas e endividamento, com poucas excepções como no caso da ELECTRA (empresa de electricidade e água), justificado pelo impacto da profunda reestruturação estratégica de que foi alvo antes da privatização.
This dissertation makes a technical assessment of Cape Verde privatizations in order to conclude about "Privatization in a small, insular and archipelago country - the Cape Verde Republic case", by the answer to a lot of questions, namely, i) the role of privatization in the strategic development option of Cape Verde and the coherence of the adopted model, program, cadence and process, ii) the evolution of the economic and financial performance of the privatized firms and iii) the impact of this evolution on the macroeconomic performance and competitiveness of the country. For that, the work is based on one part dedicated to theoretical analysis and literature research and another one to applied questions. Specifically, to find an answer to the proposed problem, it is developed, in a theoretical approach, i) a concept analysis prevailing in the dynamic of the international privatizations, ii) a literature research concerning the result on the privatized firms performance , in the applied questions, iii) the measurement of the privatization impact in the Cape Verde economic development, iv) the measurement of the privatization impact in the firms level and, finally, v) conclusions, using three references, namely, the firm situation before privatization, Price Waterhouse research about Cape Verde State Owned Enterprises before privatizations and international studies about privatized firms. The empirical research was based on a sample of 11 cape - verdeans State Owned Enterprises privatized between 1993 and 1999 and the conclusion is, in spite of the short elapsed time, there are clear evidences of i) meaningful reduction of State weight in the cape -verdean economy, ii) a positive contribution from the privatized enterprises to the macroeconomic ratios of the country and iii) improvements in the post - privatization ratios of profitability, operating efficiency, outputs and leverage, with few exceptions like ELECTRA (water and electricity enterprise), justified by the strategic alteration before privatization.
Silveira, Maria do Carmo Trovoada Pires de Carvalho. "O Ambiente Macroeconómico como Fator Crítico da Construção da Resiliência Económica de Pequenos Estados Insulares: O caso de São Tomé e Príncipe." Doctoral thesis, Instituto Superior de Ciências Sociais e Políticas, 2021. http://hdl.handle.net/10400.5/23430.
Full textA tese investiga a temática da resiliência económica de Pequenos Estados Insulares. Tomando como estudo de caso, São Tomé e Príncipe, pretende-se analisar e compreender os desafios das políticas macroeconómicas na construção da resiliência económica de uma pequena economia insular e compreender por que razão as políticas macroeconómicas implementadas neste país não têm contribuído para promover a sua resiliência económica. A investigação fundamentada na análise da bibliografia sobre a temática, nos indicadores sociais e económicos e na perceção de alguns policymakers obtida através de entrevistas de elite semiestruturadas permite-nos considerar que em São Tomé e Príncipe não foram criadas, pelos governos, as condições básicas para a construção da sua resiliência económica. Da investigação emergiram um conjunto de fatores que levam a considerar que a falta de uma visão estratégica para o crescimento económico e o desenvolvimento no médio/longo prazos, as políticas macroeconómicas não têm merecido a devida relevância no contexto das políticas públicas, ao contrário do que se observou em outros países com características similares. A fragilidade institucional aliada à falta de sentido de interesse geral condicionam o contributo das políticas macroeconómicas na promoção do crescimento económico sustentável, em particular e a promoção de mudanças para o desenvolvimento, em geral.
The thesis investigates the theme of the economic resilience of Small Island States. Taking São Tomé and Príncipe as a case study, we intend to analyze the contribution / challenges of macroeconomic policies in building the economic resilience of a small island economy to understand why policies implemented in this country have not contributed to promote its economic resilience. The research, based on the analysis of the literature on the subject, social and economic indicators as well as the perception of policymakers obtained through semistructured interviews allow us to consider that in São Tome and Príncipe the government has not created sustainable essential conditions for building the country’s economic resilience. From this research emerged a set of factors that allow to consider that due to lac of strategic vision for economic growth and development in medium/long terms, macroeconomic policies have not been given due relevance in the context of public policies, in contrast of what has been observed in other countries with similar characteristics. The institutional weakness along with lack of the sense of general interest have conditioned the contribution of macroeconomic policies in promoting sustainable economic growth, in particular, and the promotion of changes for development, in general.
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Miller, Morgan Nicholas. "State Estimation of Glucose and Insulin Dynamics." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1470954867.
Full textAili, Fagerholm Siri. "Insulin signaling in primary adipocytes in insulin sensitive and insulin resistant states." Doctoral thesis, Linköpings universitet, Avdelningen för cellbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-95562.
Full textMaoulida, Fahad. "Modélisation et optimisation d'un système hybride de génération d'énergie pour l'habitat rural en Afrique." Electronic Thesis or Diss., Université de Lorraine, 2024. http://www.theses.fr/2024LORR0043.
Full textThis thesis focuses on the development of renewable energy solutions to address the growing demand and fluctuating prices of fossil fuels. In collaboration with LERMAB of the University of Lorraine and LEMA of the University of Comoros, the study proposes hybrid systems combining solar, wind, and diesel with optimized energy storage management for rural areas in Comoros. Using software such as Homer Energy, Trnsys, and Polysun, the study designs these systems by leveraging the solar potential (5 kWh/m²/day) and wind potential (over 6 m/s) of Comoros for continuous and decarbonized energy distribution by SONELEC. Two hybrid solutions are developed in this thesis. The first, intended for a rural village, integrates wind, solar photovoltaic, and a backup diesel generator. It produces an excess of 660,087 kWh/year, representing a 74.2% energy surplus, with a cost of dollar 0.29/kWh, lower than that offered by SONELEC. Production is dominated by solar (82%), followed by wind (18%), with diesel minimized to nearly 0%, ensuring a 100% renewable share and zero gas emissions. The PV-Wind-Diesel-Battery system optimizes local resources and includes batteries to ensure stable power supply despite fluctuations. The second solution, validated at the IUT of Longwy, targets individual homes with PV/T systems for electrical energy and hot water. Combining photovoltaic panels and thermal collectors, these systems allow for dual production of electricity and heat. A hybrid PV/T collector model, designed and validated by experimental studies at LERMAB, covers 70% of hot water needs and 80% of electrical energy needs, with a total efficiency of 40%. Effective year-round, these systems remain efficient even in variable climatic conditions. This research proposes a sustainable energy policy for Comoros, aiming to reduce dependence on diesel, improve quality of life, and stimulate the local economy. It highlights the importance of financing mechanisms, training of local communities, and the integration of hybrid systems with PV/T collectors for optimal energy efficiency
Connor, Sean Denis. "Metal insulator semiconductor structures on gallium arsenide." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303649.
Full textFrangioudakis, Georgia St Vincent's Clinical School UNSW. "Insulin signal transduction in vivo in states of lipid-induced insulin resistance." Awarded by:University of New South Wales. St Vincent's Clinical School, 2004. http://handle.unsw.edu.au/1959.4/27419.
Full textWalker, Adrian Bernard. "The effect of insulin on resistance artery function in insulin-resistant states." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312450.
Full textSathyapalan, Thozhukat. "Cardiovascular risk reduction in insulin resistant states." Thesis, University of Hull, 2009. http://hydra.hull.ac.uk/resources/hull:5768.
Full textUmapathy, Chandravadhana. "THE STATE AND FUTURE OF CLOSED LOOP INSULIN PUMPS / ARTIFICIAL PANCREAS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1301604304.
Full textJazayeri, Mina. "Neural correlates of socio-emotional states in macaques." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1281/document.
Full textA cornerstone of a successful social life is the ability to correctly predict others’ actions and empathically perceive their emotional states. Studies on primates’ social interaction have shown that thanks to their keen cognitive abilities monkeys are able to deduce what others can hear or see, and to predict others’ emotions and intentions. It has been shown that primates are able to display different degrees of prosocial behavior, from cooperation to even altruism and empathically driven behavior. Studies using fMRI techniques inhumans have identified the anterior insula (AI) as a key brain region in the processing of empathy. More precisely, this region emerged as the overlapping area activated for both experienced and observed pain,leading to the idea that empathy for pain may involve a mirror-matching model of the affective and sensory features of others' pain. However, the neuronal basis of this process has yet to be uncovered. In an attempt toextend and to investigate the role of the AI in the process of empathy we have recorded single cell activity inthe AI of two monkeys while they were engaged in a social task where based on the performed trials positiveor negative reinforcements could be delivered to self, another monkey, or nobody. Behavioral results showed that monkeys take into account the welfare of their partners even when this has no impact on their ownwelfare. Our neuronal findings report that distinct population of neurons respond differentially to outcomesfor self and other, and to appetitive and aversive outcomes. Interestingly the neuronal population responding to the aversive outcome showed mainly three profiles of activity: neuronal representation of conspecifics’unpleasant experience, neuronal representation of own unpleasant experience and a minority of neurons showing mirroring properties between self and other. Thus, our results suggest a neuronal model of empathy that accounts for the distinctive features between feeling and empathizing
Doyle, Suzanne Martha. "Phase transitions in low dimensional materials close to the metal-insulator boundary." Thesis, University of Bristol, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358783.
Full textTan, Bee Kang. "Visceral adipokines, inflammation and insulin action in dysmetabolic states." Thesis, University of East Anglia, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577569.
Full textNa, Yunchung Neil. "Polaritonic quantun phase transition from a superfluid to mott-insulator state and applications /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textCox-Maksimov, Desiree. "The making of the clinical trial in Britain, 1910-1945 : expertise, the state and the public." Thesis, University of Cambridge, 1997. https://www.repository.cam.ac.uk/handle/1810/272692.
Full textWatson, Deborah Lee. "Quantum interference effects in the magnetoresistance of semiconductor structures near the metal to insulator transition." Thesis, University of Exeter, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286547.
Full textPereira, Daniela de Almeida. "The challenges of the small insular developing states: are the Mauritius and Seychelles examples for Cape Verde?" Master's thesis, Instituto Superior de Economia e Gestão, 2005. http://hdl.handle.net/10400.5/630.
Full textThis dissertation attempts to review the critical theoretical issues concerning Small States and Small Insular Developing States, while aiming to answer some crucial related questions and to distinguish between these two notions. Additionally we attempt to spotlight some issues related to the development of Cape Verde having in consideration a possible comparison with two of the most successful African SIDS, namely Mauritius and Seychelles. A brief analysis of the social and economical situation of the three countries is made, seeking to underline their key development elements and assessing their economical and social structure. This dissertation mainly aims at assessing what Cape Verde can apprehend from the Mauritian and Seychellois experience, in an attempt to draw some useful conclusions to its development.
Esta dissertação procura rever as questões teóricas essenciais que dizem respeito aos Pequenos Estados e aos Pequenos Estados Insulares em Desenvolvimento e, simultaneamente, responder a algumas questões relacionadas com este âmbito. Adicionalmente, pretendem-se destacar algumas questões relacionadas com o desenvolvimento de Cabo Verde, tendo em consideração uma possível comparação com dois dos SIDS Africanos mais bem sucedidos, nomeadamente as Maurícias e as Seicheles. Com este intuito, é efectuada uma breve apreciação da situação económica e social destes países, numa tentativa de sublinhar os seus elementos fundamentais e de analisar a sua estrutura económica e social. Esta dissertação tem como seu objectivo fundamental a apreciação do que Cabo Verde poderá apreender da experiência de desenvolvimento das Maurícias e das Seicheles, numa tentativa de elaborar conclusões frutuosas para Cabo Verde.
Maliepaard, Michael Cornelis. "The metal-insulator transition in GaAs and Inâ†0â†.â†5â†3Gaâ†0â†.â†4â†7As." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303254.
Full textNorris, Fiona Jane. "Investigations of pancreatic b-cell and gastrointestinal hormones in hyperinsulinaemic states." Thesis, University of Surrey, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362592.
Full textAllen, Hengameh G. "Role Of Membrane Lipids in Developing Insulin resistant Diabetes Mellitus Type II in Caucasians and African Americans." NCSU, 2000. http://www.lib.ncsu.edu/theses/available/etd-20001130-153236.
Full textInsulin resistance in diabetes (DMII) can result from membrane lipid (PM) changes. Membrane lipids play a major role in hormonal signal transduction and in appropriate amounts of such molecules may lead to either decreased, or increased membrane fluidity. Therefore, in this study we determined whether PM differences exist between African Americans (BL) and Caucasians (W) and if differences contribute to impaired insulin binding (IB) in DMII. Methodology: Subjects were recruited from Caucasian Control (CC) (n=10), African American Control (AC) (n=10), Caucasian Diabetics (CD) (n=5), African American Diabetics (AD) (n=10) groups. The diabetics were type II diabetics on daily insulin injections (age and sex-matched in both racial groups). The evaluations consisted of: three day dietary record, serum total cholesterol (TC), triglyceride (TRG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL), glucose (Glu), hemoglobin A1C (A1C), insulin (Ins) levels and RBC membrane lipid composition including, fatty acids, phospholipids (PL), cholesterol (CH) and RBC insulin binding (IB), RESULTS: Cholesterol intake did not show any correlations with any blood constituents, membrane lipids or membrane properties. The macronutrient intake did not show a significant correlation with blood lipid levels, membrane properties and the anthropometric measurements as expected. The triglyceride levels were higher in diabetics (P <0.01). The lipoprotein evaluation indicated significant differences in VLDL (P <0.01), LDL (P <0.05) and HDL (P <0.0001) levels between control and diabetic subjects. There were no racial differences seen among the four groups. Diabetics had higher CH and it correlated with Glu (r= 0.65, P<0.05) and IB (r= -0.61, P <0.05). The CH/PL revealed strong correlation between LDL (r=0.42, P <0.01) and HDL (r= -0.56, P <0.05). The PM trans fatty acid levels (TFA) were highest in AD (P <0.01), but no correlations with IB & Glu. The PM saturated/polyunsaturated ratio (S/P) was higher in diabetics (P <0.05) correlating with insulin level (r= 0.42, P <0.01) & IB (r= -0.45, P <0.05), but no correlations with serum lipids occurred. The PL analysis showed no significant group differences for phosphatidyl inositol (PI) levels; however, significant racial differences were observed in phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC). The W showed higher PE levels than BL and lower PC. The RBC rheological (PE/PS) properties (deformability) was lower in diabetics and AC than CC. The saturated nature of RBC [(SPH+PC)/(PE+PS)] was the lowest in CC (P< 0.056). The combination of increased S/P, and increased saturated nature, decreased PE/PS, increased CH/PL indicate decreased membrane fluidity and decreased RBC deformability, which might contribute to decreased IB in DMII. Differences in PE and PC levels between BL and W possibly indicate a racial difference in cause of insulin resistance. The racial differences in developing DMII need to be recognized so the therapeutic agents can target the exact problem in the metabolic pathway to correct the insulin resistance.
Maitra, Kingsuk. "Electron transport in bulk-Si NMOSFETs in presence of high-k insulator-charge trapping and mobility." NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-11272005-222631/.
Full textStefanou, Stefanos. "Design, fabrication and characterisation of advanced substrate crosstalk suppression structures in silicon on insulator substrates with buried ground planes (GPSOI)." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268642.
Full textTomasello, Marianna Flora. "Beta-Amyloid oligomeric and monomeric states: implications for Alzheimer's Disease." Doctoral thesis, Università di Catania, 2013. http://hdl.handle.net/10761/1285.
Full textHolmes, Anna Greer, and not supplied. "Role of interleukin-6 in states of metabolic health and disease." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070131.121620.
Full textAsp, Michelle Lynn. "Therapeutic Strategies for the Treatment of Insulin Resistance in Various Metabolic Disease States." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1280255826.
Full textLe, calvez Kévin. "Signatures of a 4pi periodic Andreev bound state in topological Josephson junctions." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAY099/document.
Full textThree dimensional topological insulators (3D TI) are a new state of matter composedof an electrically insulating bulk covered by metallic surface states. Theoretically, a topo-logical Josephson junction composed of these surface states can host an Andreev Boundstate (ABS) that has twice the periodicity of the conventional 2p periodic ABSs. The4p periodic ABS is expected to be the building block of topological quantum computing.Therefore, we study the dynamic of this particular ABS by performing Shapiro measure-ment on Josephson junctions built with bismuth based 3D TI.To identify the e?ects of a 4p periodic ABS in a Shapiro measurement, we use a phe-nomenological model that simulates the voltage-current characteristics of a TJJ. We predicttwo signatures of the 4p periodic ABS and estimate their robustness against Joule heatingand thermally activated quasiparticle poisoning of the 4p periodic mode.We study the Josephson junctions dynamics by performing Shapiro measurements onjunctions built on Bi2Se3. We observe the two previously anticipated signatures, whichare the non-conventional appearance order of the Shapiro steps and the remaining of asupercurrent at the closing of the Shapiro step n = 0. They prove the presence of a 4pperiodic ABS.We also study the topological insulator BiSbTeSe2 that we have grown by using themelting growth method. By superconducting interferometric measurements, we show asuperconducting surface transport without bulk electronic conduction
Nikolic, Aleksandar. "The physics of multilayer topological insulator heterostructures using low-energy models." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283001.
Full textSingh, Siddhartha. "Phosphorus implants for off-state improvement of SOI CMOS fabricated at low temperature /." Online version of thesis, 2009. http://hdl.handle.net/1850/11427.
Full textGhoorkhanian, Fariborz. "Numerical analysis of metal-insulator-semiconductor structure including the effects of surface states and backside Ohmic contact /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu148733154170968.
Full textDenti, Paolo. "Nonlinear Mixed-Effects Modelling of Glucose-Insulin Metabolism." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426016.
Full textIl diabete mellito è non solo una patologia molto seria, che causa disagi e sofferenze a milioni di persone nel mondo, ma, anche a causa dell’affermarsi di uno stile di vita sedentario e dell’invecchiamento della popolazione, negli ultimi decenni ha raggiunto proporzioni epidemiche, diventando una vera e propria emergenza sanitaria e sociale. Per fronteggiare questo problema, molte risorse sono state dedicate all’attività di ricerca scientifica, che ha permesso una più profonda conoscenza dell’eziologia del diabete. Tuttavia, il diabete è a tutt’oggi ancora inguaribile e molte questioni rimangono aperte, fra cui la completa comprensione dei fattori che causano e fanno progredire la malattia. Anni di ricerca hanno permesso di sviluppare molti sofisticati strumenti per studiare il sistema metabolico glucosio-insulina in vivo e poter così fronteggiare il problema dell’inaccessibilità diretta di alcuni dei fenomeni chiave che controllano la glicemia. Tali strumenti, fra cui protocolli di studio e approcci basati su modello usati per interpretare i dati sperimentali, si sono rivelati armi molto potenti nelle mani dei ricercatori, ma le proporzioni epidemiche della malattia e il parziale cambiamento delle strategie e obiettivi della ricerca hanno sollevato l’esigenza di poter disporre di metodologie meno invasive, più economiche, e quindi più adatte ad essere applicate ad estesi studi clinici. Alcuni strumenti matematici e statistici che sono collettivamente conosciuti con il nome di “approcci di popolazione” sono già stati sviluppati e vengono largamente impiegati in studi di farmacocinetica e farmacodinamica, per lo sviluppo di farmaci. Tali approcci si prefiggono come obiettivo primario di stimare la distribuzione dei parametri di un modello all’interno di una popolazione e pertanto si avvalgono, per la stima individuale, delle informazioni disponibili sull’intero gruppo di soggetti. Sono particolarmente adatti a situazioni in cui il campionamento intensivo in un singolo soggetto non è possibile, e quando l’interesse del ricercatore è focalizzato sulla variabilità inter-individuale. Tuttavia, nonostante le loro interessanti potenzialità, gli approcci di popolazione non sono ancora apprezzati all’interno dell’ambiente di ricerca sulle malattie metaboliche, e la loro applicazione in tali studi è stata molto limitata. Pertanto è necessaria dell’attività di ricerca per saggiare l’effettiva fattibilità e rilevanza dell’utilizzo di tali approcci nello studio del diabete. La ricerca qui presentata risponde a queste esigenze, proponendosi come obiettivo l’applicazione di queste sofisticate tecniche ai modelli di metabolismo del glucosio, prima testandone la fattibilità e adattandole al problema in esame, e poi impiegandole nell’analisi di dati raccolti in studi di popolazione. Poiché in letteratura sono stati proposti molti diversi algoritmi, come primo passo, un dataset simulato è stato utilizzato per effettuare un confronto delle metodologie quando applicate al modello minimo del glucosio per il Test di Tolleranza IntraVenosa al Glucosio (IVGTT). First-Order Conditional Estimation (FOCE) si è rivelato come l’algoritmo più soddisfacente, in quanto ha fornito i risultati più accurati e robusti in caso di scarsità o rumorosità dei campioni. Successivamente, per validare i risultati trovati su dati reali, l’analisi è stata ripetuta su un dataset più esteso, relativo a 204 soggetti sani testati con IVGTT. Per poter saggiare la bontà delle soluzioni fornite dai vari algoritmi, è stato impiegato un sistema di stima della likelihood function basato su campionamento Monte Carlo. Questa analisi, non solo ha permesso di confermare la scelta di FOCE come metodo preferenziale, ma si è anche rivelata come un potente strumento per valutare la precisione delle stime dei parametri di popolazione. Successivamente, è stato messo a punto e ottimizzato un modello di popolazione, conservando nella matrice di covarianza solo i termini di correlazione fra i parametri SI-P2 e SG-VOL. Questo modello è servito come base per la successiva integrazione di covariate nel modello. Al momento dell’esecuzione degli esperimenti, infatti, sono stati raccolti alcuni dati sui pazienti, fra cui altezza, peso, sesso, età, glicemia e insulinemia basali, informazioni sul grasso corporeo. È stata effettuata una analisi per determinare quali fra queste variabili potessero essere usate per spiegare parte della variabilità nei valori dei parametri del modello minimo fra i diversi soggetti. Il risultato è un modello che integra queste informazioni direttamente nelle sue equazioni, mentre i coefficienti di regressione per ognuno dei predittori diventano veri e propri parametri del modello e il loro valore viene ottimizzato insieme agli altri parametri di popolazione. L’analisi effettuata ha trovato come buoni predittori per SI e P2 l’ età, l’insulinemia basale e il grasso addominale, che in ambo i parametri riescono a spiegare una buona fetta della variabilità inter-individuale. Sia l’impiego di metodologie di popolazione, sia l’introduzione delle covariate nel modello, permettono di aumentarne il potere predittivo, e sono in grado di usare informazioni indipendenti dai soli dati sperimentali. Questo permette di mettere a punto dei protocolli di studio meno invasivi, meno costosi, e pertanto più adatti ad un impiego su larga scala: ulteriore ricerca potrebbe avere come obiettivo l’ottimizzazione di una sampling schedule ridotta, che si avvantaggi dell’utilizzo degli approcci di popolazione. Ad ogni modo, il dataset utilizzato in questa analisi comprende solo soggetti sani, ed è quindi caratterizzato da una quantità limitata di variabilità di popolazione. Pertanto, sarebbe necessario ripetere l’analisi su altri dataset, per poter confermare questi risultati, in particolare sulle covariate. Inoltre, in una sezione successiva, un metodo di popolazione è stato applicato anche ad un altro problema diverso, la stima del Disposition Index (DI) del glucosio. Questo è un indice calcolato combinando sensitività e responsività all’insulina, che serve per testare l’effettiva efficacia del sistema di controllo della glicemia. Ci sono due versioni proposte per la formula, una semplificata, che consiste semplicemente nel prodotto (da cui il nome di Legge Iperbolica), e una con un parametro aggiuntivo ad esponente della sensitività all’insulina. Per poter calcolare il DI medio in una popolazione, e per poter saggiare quale delle due formule sia effettivamente più adatta, in letteratura si trovano alcuni approcci basati su un fit geometrico. Tuttavia, alcune approssimazioni sono utilizzate per semplificare il fit, e sono molte le questioni metodologiche spesso sottovalutate. Pertanto viene presentato qui un nuovo metodo Total Least Squares (TLS) che affronta il problema senza l’impiego di approssimazioni. Grazie ad alcune simulazioni, si è effettuato un paragone fra i vari metodi disponibili, e il nuovo algoritmo è risultato migliore rispetto ai predecessori. Tuttavia, tutti gli algoritmi basati su fit si fondano sull’ipotesi che i soggetti appartenenti alla popolazione abbiano lo stesso valore di DI, e l’unica fonte di incertezza nei dati sia dovuta alla stima degli indici di secrezione e sensitività. Questa ipotesi sembra una forte semplificazione e, in effetti, l’analisi di un dataset reale sembra confermare la presenza di variabilità di popolazione nei valori del DI. Ulteriori simulazioni hanno confermato che tutti metodi basati su fit, TLS compreso, falliscono quando la variabilità di popolazione è presente. Pertanto, è stato ideato un altro metodo basato su approcci di popolazione e, in particolare, su NonLinear Mixed-Effects Models (NLMEM), che è in grado di separare la variabilità nei dati, poiché fondato su ipotesi meno restrittive. Tale algoritmo stima i parametri della distribuzione di probabilità congiunta degli indici di secrezione e sensitività, e poi estrae le informazioni sul DI dalla matrice di covarianza. NLMEM si è rivelato equivalente a TLS quando non c’è variabilità di popolazione, ma di gran lunga più affidabile quando le ipotesi per il fit geometrico non sono rispettate, pertanto si è deciso di utilizzarlo sul dataset reale per testare la validità della legge iperbolica. Anche se una validazione su altri dataset è auspicabile per validare i risultati qui presentati, il modello con il parametro aggiuntivo sembra spiegare i dati in maniera più soddisfacente, e il valore del parametro sembra dipendere dalla coppia di parametri usata per la definizione del DI, più che dalla popolazione in esame (anziani piuttosto che giovani). Inoltre, nello studio qui proposto, il punto di partenza sono stati i valori degli indici di secrezione già calcolati, insieme con la loro precisione, grazie ad un metodo tradizionale; un approccio ancora più potente consisterebbe nell’utilizzare un modello di popolazione per stimare contemporaneamente sia gli indici di secrezione che sensitività, sia i parametri della loro distribuzione di popolazione, da cui ricavare le informazioni sul DI. Riassumendo, in questo lavoro si sono messi in luce i vantaggi dell’applicazione di approcci di popolazione nello studio nel diabete. Le potenzialità sono molte, dal miglioramento delle stime dei parametri individuali grazie all’uso dei prior di popolazione o di covariate e la relativa possibilità di mettere a punto protocolli di studio più leggeri, fino all’analisi di situazioni in cui la struttura gerarchica della variabilità è un aspetto cruciale.
Pillai, Lakshmi Rajan. "Investigations of the roles of G protein-coupled receptors and receptor tyrosine kinases in metabolic syndrome and cancer." Master's thesis, Mississippi State : Mississippi State University, 2008. http://library.msstate.edu/etd/show.asp?etd=etd-07102008-171046.
Full textSchneider, Harald Jörn, Bernhard Saller, Jens Klotsche, Winfried März, Wolfgang Erwa, Hans-Ulrich Wittchen, and Günter Karl Stalla. "Opposite associations of age-dependent insulin-like growth factor-I standard deviation scores with nutritional state in normal weight and obese subjects." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-100946.
Full textSchneider, Harald Jörn, Bernhard Saller, Jens Klotsche, Winfried März, Wolfgang Erwa, Hans-Ulrich Wittchen, and Günter Karl Stalla. "Opposite associations of age-dependent insulin-like growth factor-I standard deviation scores with nutritional state in normal weight and obese subjects." BioScientifica, 2006. https://tud.qucosa.de/id/qucosa%3A26325.
Full textEngland, Troy Daniel. "Silicon-germanium BiCMOS and silicon-on-insulator CMOS analog circuits for extreme environment applications." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51806.
Full textBerntsen, Magnus H. "Consequences of a non-trivial band-structure topology in solids : Investigations of topological surface and interface states." Doctoral thesis, KTH, Material- och nanofysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-121974.
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Konishi, Hideki. "Collisional stability of localized metastable ytterbium atoms immersed in a Fermi sea of lithium." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225386.
Full textMilinavičienė, Eglė. "Veiksnių, turinčių įtakos sergančiųjų galvos smegenų insultu reabilitacijos efektyvumui, įvertinimas ir jų prognozinės vertės nustatymas antruoju reabilitacijos etapu." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20081022_084322-57754.
Full textStroke is one of the most relevant public health issues due to high mortality and long-lasting disability rates around the world and in Lithuania. As a consequence, stroke patients stay with such functional disorders as motoric, self-care, and cognitive dysfunctions, that impair their life satisfaction. Complex rehabilitation improves functional status in stroke patients. However, the recovery of functional status in stroke patients is different even if stroke diagnosis is the same. Aim of the study: to establish factors, influencing the effectiveness of second stage rehabilitation, and to evaluate their predictive value in stroke patients. Goals of the study: 1. to evaluate clinical and functional status, motoric and cognitive dysfunctions and its dynamics during second stage rehabilitation in stroke patients; 2. to establish the effectiveness of complex second stage rehabilitation depending on patients' age, gender, type of stroke, damage localization, and severity of stroke; 3. to establish the factors, influencing the effectiveness of rehabilitation and to evaluate their predictive value in stroke patients. Our study demonstrated, that older age, damage in left brain hemisphere, and severity of neurologic condition as measured at baseline all are related with subsequent functional status at the end of second stage rehabilitation. The study investigated, that low rehabilitation effectiveness during second stage rehabilitation on general functional status is predicted... [to full text]
Sarkar, Deboleena Dipak. "Potential Role Of Endoplasmic Reticulum Redox Changes In Endoplasmic Reticulum Stress And Impaired Protein Folding In Obesity-Associated Insulin Resistance." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/306999.
Full textJamontaitė, Ieva Eglė. "Physiotherapy and cycling training influence to patient's independence and mobility in early stage after stroke." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090507_135137-44198.
Full textKineziterapijos ir ciklinės treniruotės poveikis asmenų savarankiškumui ir mobilumui ankstyvuoju reabilitacijos periodu po galvos smegenų insulto Moksliniais tyrimais įrodyta, kad kineziterapija yra efektyvi reabilituojant pacientus po galvos smegenų kraujotakos sutrikimų. Atlikti įvairūs kineziterapijos efektyvumą analizuojantys tyrimai naudojant paprasčiausias kineziterapijos priemones bei sudėtingus aparatus įvairiais periodais pacientams po insulto. Tačiau ne visada siūlomi metodai buvo efektyvūs, nepakankamai nagrinėti metodai gerinantys pacientų pusiausvyros ir ėjimo funkcijas ankstyvuoju reabilitacijos periodu po insulto. Išlieka aktuali naujų metodikų paieškos problema, kaip pagreitinti pusiausvyros ir ėjimo funkcijų atsigavimą bei sutrumpinti pacientams po galvos smegenų insulto reabilitacijos periodą. Tyrimo metu taikytas Bobath‘o metodikos ir veloergometro treniruotės derinys pacientams po galvos smegenų insulto ankstyvuoju reabilitacijos periodu. Treniruotė veloergometru pasirinkta todėl, kad juo atliekamas dinaminis, bilateralinis veiksmas daug kuo panašus į ėjimą, tačiau yra saugesnis ir gali būti pradėtas taikyti ankstyvuoju periodu po insulto. Be to, šis metodas pagreitina kompensacinius mechanizmus. Įvertinta, kad kineziterapijos programa, kurios metu buvo taikoma Bobath‘o metodika ir ciklinė treniruotė, labiau veikė asmenų po galvos smegenų infarkto savarankiškumą, pusiausvyrą ir ėjimą negu programa, kurios metu buvo taikoma tik Bobath‘o metodika (p<0,05)... [toliau žr. visą tekstą]
Claudia, Cecilia Yamamoto Noguchi. "Mathematical Model of Glucose-Insulin Metabolism Considering Meal Absorption Rate and Model-based Blood Glucose Control for Prandial State in Type 1 Diabetes." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/217171.
Full textKunst, Flore Kiki. "Topology Meets Frustration : Exact Solutions for Topological Surface States on Geometrically Frustrated Lattices." Licentiate thesis, Stockholms universitet, Fysikum, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-150281.
Full textJamison, John S. "Time and Space Resolved Spin-Heat Transport in the Magnetic Insulator Yttrium Iron Garnet." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586740671277489.
Full textNascimento, Lígia Maria dos Santos. "Relação de São-Tomé e Príncipe com Taiwan: balanço dos anos de cooperação." Master's thesis, Instituto Superior de Ciências Sociais e Políticas, 2019. http://hdl.handle.net/10400.5/17485.
Full textA relação Diplomática entre São-Tomé e Príncipe e Taiwan, estabelecida em Maio de 1997, é considerada um dos acordos mais polémicos na história da diplomacia São-Tomense. Foi assim considerada pois o acordo implicou o rompimento das relações diplomáticas de SãoTomé e Príncipe com a República Popular da China (RPC), país que apoiara a sua luta de libertação e com quem mantinha cordiais relações de cooperação. Ainda que contestada, a relação com Taiwan manteve-se por duas décadas apesar de momentos de conturbação, tendo este país implementado em São Tomé e Príncipe diversos projectos com destaque para as áreas da saúde, da agricultura e da educação. É nesse sentido, que o presente trabalho vai centrar-se sobre a relação entre os dois estados insulares, analisando os seus antecedentes, a sua evolução e o seu término para apurar até que ponto esta cooperação foi benéfica e contribuiu para o desenvolvimento do arquipélago São -Tomense.
The diplomatic relationship between Sao Tome e Principe and Taiwan that was established in May 1997 was considered one of the most controversial agreement in the diplomatic history of Sao Tome and Principe because this agreement forced the severance of the relationship between Sao Tome and Principe and Popular Republic of China, a country that had supported São Tome independence struggle and the post-colonial government. Even so the relationship lasted almost two decades although there were moments of some troubles, having Taiwan implemented several projects, particularly in the areas of health, agriculture and education. It is in this sense that the present works will focus more in the referred relationship, its background, its evolution and terms and analyze to what extent this cooperation will contribute to the development of the archipelago.
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Sleeper, Mark D. "The effect of an equi-intensity treadmill running and swimming training protocol on the adipocyte insulin sensitivity and responsiveness in the rat." Virtual Press, 1987. http://liblink.bsu.edu/uhtbin/catkey/482304.
Full textOlsson, Pontus. "Påverkas människan på olika sätt av uthållighetsträning på fastande respektive icke-fastande mage vad gäller fysiologiska markörer i kroppen?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-65718.
Full textIntroduction: Endurance training is defined as the type of exercise where most major muscle groups are used in need of the cardiovascular system’s ability to transport oxygen to the muscles. Fasting means in most studies that no type of food is taken before the workout while not fasting usually means that a carbohydrate meal is taken 90 minutes before a workout. Insulin is important in fat, protein and carbohydrate metabolism as well as in the collection of sugar in the blood. Glycogen acts as an energy reserve in the skeletal muscles. Free fatty acids are important to provide energy for the cellular metabolism that can continue. Aim of the study: The aim of the study was to find out if the body is affected in different ways by endurance training exerted in fasted respectively non-fasting state regarding insulin, muscle glycogen and free fatty acids in humans. Methods: Literature search in OneSearch with the words training* AND fasted state where six articles were selected. Cohen’s D was used to give the results of the studies an effect size. Confidence interval was used to determine if the studies were statistically significant. Results: Three studies investigated insulin, where the results showed that all groups that did not fast before the workouts had the lowest concentration of insulin during the rest period after the test. All six studies investigated muscle glycogen, where the results showed that the concentration of muscle glycogen was highest after post-test in the group that fasted before the workouts in five out of six studies. Three studies investigated free fatty acids where the results showed that the concentration of free fatty acids were lowest in the post-test in the group that fasted before the workouts in two of three studies. Discussion: Training in the non-fasting state causes the glycogen levels to be saved, which in turn leads to increased oxidation of insulin resulting in lower concentrations of insulin after the post-test. Training in the fasted state results in increased concentration of muscle glycogen for energy maintenance and higher levels of β-hydroxyacyl coenzyme A dehydrogenase (β-HAD), citrate synthase activity (CS activity) and succinate dehydrogenase activity, leading to increased muscular oxidative capacity. Intake of carbohydrates prior to a workout leads to increased glycogen saving, resulting in lower concentrations of muscle glycogen compared to non-fasted state. Higher concentration of muscle glycogen before the pretest leads to higher concentrations of muscle glycogen in the post-test. Training in fasted state results in lower concentrations of free fatty acids due to increased FATmax (maximum rate of fat burning), increased maximal oxidative enzyme activity, hormone sensitive lipase (HSL) upset, increased fatty acid translocase / CD36 protein expression (FAT / CD36) as well as increased membrane bound protein binding protein which leads to increased fat burning. The concentration of free fatty acids was also increased in a study due to the fact that insulin secretion should not fall too low in the group that fasted before the workouts. Conclusion: The results showed that in three out of three studies, the insulin concentration was lowest after the post-test in the group who took a carbohydrate meal before the workouts. In five out of six studies, the concentration of muscle glycogen was highest after the post-test in the group that fasted before the workouts. In two out of three studies, the concentration of free fatty acids was lowest after the post-test in the group that fasted before the workouts. These results increase the understanding of how exercise in the fasted state and non-fasted state affects the body with regard to insulin, muscle glycogen and free fatty acids. Further research could investigate these three physiological markers for six months to see if the results are the same in these two groups.
Taghibiglou, Changiz. "Molecular mechanisms regulating the assembly and secretion of apolipoprotein B in hamster liver and its overproduction in insulin resistant states." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ63693.pdf.
Full textFRANCESCATO, GAIA. "CRESCITA ED INDICI METABOLICI PRECOCI DELLO STATO NUTRIZIONALE IN FIGLI DI MADRE DIABETICA." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/151791.
Full textBautista, Anthony. "TUNNELING SPECTROSCOPY STUDY OF CALCIUM RUTHENATE." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/784.
Full textMorvan, Alexis. "Honeycomb lattices of superconducting microwave resonators : Observation of topological Semenoff edge states." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS037/document.
Full textThis thesis describes the realization and study of honeycomb lattices of superconducting resonators. This work is a first step towards the simulation of condensed matter systems with superconducting circuits. Our lattices are micro-fabricated and typically contains a few hundred sites. In order to observe the eigen-modes that appear between 4 and 8 GHz, we have developed a mode imaging technique based on the local dissipation introduced by a laser spot that we can move across the lattice. We have been able to measure the band structure and to characterize the edge states of our lattices. In particular, we observe localized states that appear at the interface between two Semenoff insulators with opposite masses. These states, called Semenoff states, have a topological origin. Our observations are in good agreement with ab initio electromagnetic simulations
Lau, Alexander. "Symmetry-enriched topological states of matter in insulators and semimetals." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-233930.
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