Dissertations / Theses on the topic 'Innovation targets'
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Liu, Dawei. "Target and small molecule discovery for therapeutic innovation in cardiovascular area." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS324.
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La production cyclique d'adénosine monophosphate (AMPc) régule certains aspects de la fonction mitochondriale des cardiomyocytes de rongeurs, tels que la production d'ATP, la consommation d'oxygène, les importations de calcium et la transition de perméabilité mitochondriale (MPT), mais le contrôle de ce pool d'AMPc n'est pas bien connu. Dans la première partie de cette thèse, nous avons étudié l'expression, la localisation et l'activité de plusieurs enzymes dégradant l'AMPc, les phosphodiestérases (PDEs), dans des mitochondries cardiaques isolées de rongeurs. L'expression de la PDE2 a été principalement détectée dans les mitochondries sous-sarcologiques, et l'activité de la PDE2 stimulée par le GMPc était plus importante que celle de la PDE3 et de la PDE4; leurs activités ont ensuite été confirmées dans les cardiomyocytes de rats nouveau-nés par analyse FRET en temps réel. De plus, l’inhibition pharmacologique ou la surexpression cardiaque spécifique de la respiration mitochondriale modulée par la PDE2, la perte de potentiel de la membrane mitochondriale, le MPT et l’importation de calcium. Ainsi, la dégradation de l'AMPc par les PDE représente un nouveau mécanisme de régulation de la fonction mitochondriale et devient une cible potentielle dans le traitement des maladies cardiovasculaires.En outre, l'amélioration récente du traitement anticancéreux entraîne une augmentation du nombre de patients survivants, mais un risque de cardiotoxicité à long terme. Ainsi, dans la deuxième partie de cette thèse, nous avons identifié des molécules cardioprotectrices à partir de bibliothèques chimiques en développant un test de criblage à haut débit. Nous avons identifié 6 molécules à effets puissants et spécifiqies et les avons validés dans 3 modèles cellulaires. Nous avons étudié les mécanismes d'action de chaque molécule en utilisant l’extinction par siARN, l'analyse par western blot, l'imagerie par fluorescence et les analyses métaboliques en temps réel. Trois molécules pourraient entrer rapidement dans les études précliniques et cliniques en association avec des agents de radiothérapie ou des agents chimiothérapeutiques pour le développement thérapeutique, tandis que les trois autres molécules pourraient nécessiter une optimisation chimique supplémentaireCyclic adenosine monophosphate (cAMP) production regulates certain aspects of mitochondria function in rodent cardiomyocytes, such as ATP production, oxygen consumption, calcium imports and mitochondrial permeability transition (MPT), but how this cAMP pool is controlled is not well known. In the first part of this thesis, we investigated the expression, localization and activity of several cAMP-degrading enzymes, phosphodiesterases (PDEs), in isolated rodent cardiac mitochondria. PDE2 expression was mainly detected in subsarcolemmal mitochondria, and cGMP-stimulated PDE2 activity was largest than PDE3 and PDE4, their activities were further confirmed in neonatal rat cardiomyocytes by real time FRET analysis. Moreover, the pharmacological inhibition or the cardiac-specific overexpression of PDE2 modulated mitochondrial respiration, mitochondrial membrane potential loss, MPT and calcium import. Thus, cAMP degradation by PDEs represents a new regulatory mechanism of mitochondrial function, and becomes a potential target in cardiovascular diseases therapy.In addition, the recent improvement of anticancer treatment results in an increase in surviving patients, but with a risk of long-term cardiotoxicity. Thus, in the second part of this thesis, we identified cardioprotective molecules from chemical libraries by developing a high throughput screening assay. We identified 6 potent and specific hits and validated them in 3 cellular models. We investigated the mechanisms of actions of each molecule and their cellular impact by using siRNA silencing, western-blot analysis, fluorescent imagery and real-time metabolic analyses. Three molecules could enter rapidly in preclinical and clinical studies in combination with radiation or chemotherapeutic agents for therapeutic development, while other three molecules may require further chemical optimization
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Esteve, Arenys Anna. "Innovative targeted therapies for chemorefractory B-cell non-Hodgkin lymphomas." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565937.
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Lymphomas are a heterogeneous group of tumors characterized by the proliferation of lymphocytes predominantly in lymphoid structures but also in extranodal tissues. More than 90% of patients are afflicted by lymphomas of B-cell origin.
The current World Health Organization (WHO) classification of hematopoietic and lymphoid tumors categorizes B-cell neoplasms in more than 40 distinct disease entities, according to a combination of the morphology, immunophenotype, genetic, molecular and clinical features. Each entity has its own clinical course and requires specific treatments.
The characterization of activated signaling pathways involved in survival and proliferation, together with the development of a wide pharmacological armamentarium against cancer, have facilitated the bench-to-bedside translation of new targeted therapies in B-cell non-Hodgkin lymphomas (B-NHL). These novel therapies include two of the most relevant drugs lately approved: the anti-apoptotic agent venetoclax and the BTK inhibitor ibrutinib.
One major hurdle to their successful application is the rise of drug resistance. Resistance to therapy is observed in many cases of B-cell malignancies. This phenomenon significantly limits the utility of the current therapeutic strategies, and remains a substantial challenge for the clinical management of patients with advanced cancers. Resistance comes in two flavors: intrinsic resistance (also known as innate or de novo resistance) and acquired resistance, resulting from the clonal evolution of resistant variants.
With this concept in mind, in this thesis we have explored new approaches to overcome the development of drug resistance.
Venetoclax (ABT-199) is a first-in-class BH3 mimetic, FDA-approved for use in patients with R/R del17p chronic lymphocytic leukemia. In the clinical setting, it has demonstrated high response rates and good toxicity profiles in other subtypes of relapsed/refractory non-Hodgkin lymphoma.
We proposed a model of double hit lymphoma (DHL) resistance to ABT-199 in which the capacity of CPI203 to regulate the transcriptome of the cells could help to circumvent this problem. In ABT-199 sensitive cells, the BH3 mimetic acts by displacing BIM from BCL-2 complexes, allowing the de-repression and/or direct activation of BAX and leading to an activation of mitochondrial outer membrane permeabilization. In DHL cells, a compensatory upregulation of BFL-1 would bind and inactivate the pool of BIM proteins released from BCL-2 by ABT-199, avoiding MOMP and preserving cell survival. CPI203 primes cells to death by decreasing BFL-1 and
increasing BIM protein levels, and its combination with ABT-199 allows to tip the balance between pro- and anti-apoptotic signaling toward induction of cell death. This concept provides a new insight in the proposed mechanisms of resistance to BH3- mimetics in NHL cell lines, where MCL-1 and BCL-XL have been proposed as the major determinants of drug sensitivity and acquired resistance.
On the other hand, ibrutinib is a BTK inhibitor approved for first-line therapy in patients with chronic lymphocytic leukemia, as well as for the treatment of some relapsed/refractory B-NHL. Despite its high level of clinical activity, acquiring of mutations or re-wiring of the BCR pathway to retain the downstream signaling appears to be a common mechanism of resistance.
The inhibition of more than one BCR kinase might be useful in B-NHL cases that are resistant to the sole inhibition of BTK. We describe the compound IQS019 as a new BCR kinase inhibitor able to counteract both constitutive and ligand-dependent activation of the BCR pathway. Its capacity to inhibit the three upstream BCR kinases, BTK, SYK and LYN, confer an advantage over the inhibition of BTK alone by ibrutinib, in in vitro and in vivo models of B-NHL, being of special importance for the treatment of those patients with non-canonical NF-κB activation, who are low responders to ibrutinib.
Therefore, the development of innovative therapeutic approaches that permit to overcome drug resistance opens a window to important therapeutic advances in the treatment of B-NHL.Las neoplasias linfoides de célula B constituyen un grupo heterogéneo de tumores caracterizados por la proliferación de linfocitos B. Cada entidad clínica posee unas características particulares y requiere de un tratamiento específico. A pesar de los importantes avances terapéuticos, la supervivencia a largo plazo sigue siendo baja y precisa de un desarrollo constante de nuevas aproximaciones terapéuticas. Uno de los mayores problemas asociados a la respuesta a fármacos son las resistencias. En muchos casos estas resistencias se deben a cambios en proteínas diana o a la modulación compensatoria de otras proteínas o vías de señalización. El conocimiento de estos cambios será de gran importancia para poder encontrar aproximaciones terapéuticas que permitan eliminar estas resistencias. El linfoma doble-hit es un linfoma agresivo caracterizado por su baja respuesta a la quimioterapia estándar. Entre los múltiples agentes terapéuticos específicos actualmente en desarrollo encontramos el inhibidor de BCL-2, venetoclax. El venetoclax ha demostrado ser efectivo en varios subtipos de linfoma pero su uso conlleva el problema de la aparición de resistencias. Varios estudios han destacado el papel de proteínas de la familia BCL-2 en este proceso. Nuestros resultados indican que la regulación positiva de BFL-1 es uno de los factores clave en el desarrollo de resistencias al fármaco. Su regulación mediante el CPI203, un modulador epigenético, resulta en una sensibilización al venetoclax, tanto in vitro como in vivo. Por otro lado, la señalización de los receptores de células B (BCR) contribuye a la patogénesis de las neoplasias malignas de células B y ha surgido como una nueva diana terapéutica en varios tipos de linfoma. Así, los inhibidores de quinasas de la vía del BCR constituyen una estrategia terapéutica prometedora. Dentro de este grupo de fármacos destaca el inhibidor de Btk ibrutinib, que ha conseguido esperanzadoras tasas de respuesta pero que también se ve afectado por la aparición de resistencias. Nuestro trabajo muestra que el compuesto IQS019, inhibidor de varias quinasas de la vía del BCR (Btk, Syk y Lyn), posee un potente efecto antitumoral y permite escapar a las resistencias observadas al ibrutinib. Así, supone un buen tratamiento para varios subtipos de linfomas de células B, incluyendo aquellos poco sensibles a los inhibidores de quinasa de BCR actuales.
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Vaverková, Pavla. "Process Innovation Efficiency Evaluation in IT Organisation." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2019. http://www.nusl.cz/ntk/nusl-402046.
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Diplomová práce je zaměřena na měření efektivnosti procesních inovací ve společnosti Red Hat Czech s.r.o. Práce je rozdělena do tří částí. První část práce se zabývá teoretickými poznatky. Ve druhé části se jedná o představení společnosti a pochopení interních procesů a systémů firmy. Poslední část obsahuje návrhy na zlepšení tohoto projektu, které vychází z analýzy současné situace společnosti.
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Khair, Marcelo. "An innovative framework of targeted public policies for minority women in Brazil." CONNECT TO ELECTRONIC THESIS, 2007. http://dspace.wrlc.org/handle/1961/4186.
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Carless, David. "Curriculum innovation in the primary EFL classroom : case studies of three teachers implementing Hong Kong's target-oriented curriculum (TOC)." Thesis, University of Warwick, 2001. http://wrap.warwick.ac.uk/36390/.
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The central focus of this study is to explore how three primary school teachers were implementing Hong Kong's Target-Oriented Curriculum (TOC) in their lower primary English classrooms. TOC is a task-based, process-oriented innovation, introduced from 1995 onwards. The study involved a case study approach by which teachers' perceptions and behaviours were analysed during the period of a single academic year. Data collection methods for the study comprised mainly classroom observation and interviews. The former involved the study of five or six consecutive English lessons for each teacher in three separate cycles, the latter involved six semi-structured interviews per teacher. The emphasis was on qualitative data and analysis, although quantitative classroom and attitude scale data were also collected. The main findings from the study were as follows. Teacher A was positively oriented towards TOC, had a sound understanding and was implementing TOC principles to a high degree. Teacher B was somewhat neutrally disposed towards the innovation, was only in the process of developing an understanding of it, and was not implementing it as much as teacher A. Teacher C was very positively oriented towards TOC, had a sound understanding of its principles but was only able to implement it to a similar extent to teacher B. The main significance of the study includes: insights into research methodology derived from the execution of the study; confirmation and development of the theory of the management of change; insights into the classroom implementation of the key TOC classroom principles, task-based learning and catering for individual learner differences; and implications on the cultural appropriateness of TOC for the Hong Kong context.
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Muca, Sonia. "Implementazione di un modello di controllo per la definizione dei target di iniezione di combustioni innovative." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
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Con il presente lavoro di tesi è stato sviluppato e implementato un modello di controllo in Simulink per la definizione dei target di iniezione e la transizione di un motore ad accensione spontanea in condizioni di alimentazione Dual Fuel.
Il modello è costituito da due sottosistemi con finalità diverse: uno deputato al passaggio in Dual Fuel (diesel/benzina) e l’altro per tornare alla condizione di sicurezza di alimentazione diesel.
Una volta verificato il corretto funzionamento nelle prove numeriche, è stato sperimentato sul motore presente in banco prove e i test sperimentali sul modello sono stati esposti nel presente lavoro.
Questo modello rappresenta uno spunto per potenziali sviluppi sul controllo di combustioni innovative.
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Harris, Alesha N. "Targeted and Metal-loaded Polymeric Nanoparticles As Potential Cancer Therapeutics." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc500025/.
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Polymeric nanoparticles were designed, synthesized, and loaded with metal ions to explore the therapeutic potential for transition metals other than platinum found in cisplatin. Nanoparticles were synthesized to show the potential for polymer based vectors. Metal loading and release were characterized via Inductively Coupled Plasma Mass Spectrometry (ICP MS), Energy Dispersive X-Ray Spectroscopy (EDX), X-Ray Photoelectron Spectroscopy (XPS), and Elemental Analysis. Targeting was attempted with the expectation of observed increased particle uptake by cancer cells with flow cytometry and fluorescence microscopy. Results demonstrated that a variety of metals could be loaded to the nano-sized carriers in an aqueous environment, and that the release was pH-dependent. Expected increased targeting was inconsistent. The toxicity of these particles was measured in cancer cells where significant toxicity was observed in vitro via dosing of high copper-loaded nanoparticles and slight toxicity was observed in ruthenium-loaded nanoparticles. No significant toxicity was observed in cells dosed with metal-free nanoparticles. Future research will focus on ruthenium loaded polymeric nanoparticles with different targeting ligands dosed to different cell lines for the aim of increased uptake and decreased cancer cell viability.
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Tawakkoli, Sammy-Sebastian, and Leo Ekbom. "Longboards." Thesis, Karlstad University, Division for Engineering Sciences, Physics and Mathematics, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-1867.
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”Longboards” är ett examensarbete utfört av Leo Ekbom och Sammy-Sebastian Tawakkoli för innovations- och designingejörsprogrammet vid fakulteten för teknik och naturvetenskap på Karlstads Universitet. Uppdragsgivaren är Space Production AB, projektägare är Dan Edanius, art director och projektledare på företaget. Ett av företagets projekt var våren 2008 att producera Slalom Skateboarding VM och med anknytning till detta växte ett examensarbete fram.
Space Production AB började som ett montersnickeri men har idag utvecklats till ett företag som driver fullständiga utställnings- och eventprojekt. Företaget tillhandahåller allt från idéskiss till montering och servning även då huvudsysslan ligger i att producera, installera och lagra utformning från annan part.
Uppgiften var att ta fram en produktserie innehållande tre modeller av longbaords med bred spridning. Produkterna skulle vara unika och nischade men ändå säljbara och tillhöra ett övre segment av marknaden. Därtill gavs lite friare händer i att ta fram en rad vilda koncept som idébank för senare projekt.
Genom en djupgående researchfas, där information rörande materialkunskap, marknad, målgrupper och kultur, mynnade projektet ut i en kreativ designprocess. Målgruppsanalysen lade grunden till en rad referenskunder vars behov inspirerade och analyserades. Två skilda idegenereringstillfällen lade grunden till en kategorisering där åtta starka koncept presenterades för en sammansatt styrgrupp.
Arbetet resulterade i tre längre utvecklade koncept vilka har potential att bredda den befintliga marknaden för longboard försäljning samt en idébank för framtida utveckling av produkter.
”Longboards” is a degree project in the Innovations- and design engineering program at Karlstad University. The job requestor is Space Production AB with Dan Edanius, Art director and senior project manager, as the project owner.
Space Production AB started out as a showcase carpentry company but has today evolved into a company that operates complete exhibitions and events. The company’s main business is to produce, install and store branded environments designed by another party but also supplies everything from idea sketches to assemblage and service. One of Space projects spring 2008 was the production of Slalom Skateboarding World Championships and it was through this a degree project was created.
The task was to create a diverse product line containing three models of longboards. The products would be unique and aimed at a niche market but yet be sellable and appeal to the upper segment buyer. Further the opportunity to create more wild concepts that could be used in future projects was given.
An extensive research on materials, market, target group and culture, resulted in a creative design process. Through a target group analysis a number of reference consumers were created. Their needs worked as inspiration and was analysed. Two separate sessions of idea generating were the fundament of a categorization that eventually resulted in eight strong concepts that was presented to the management group.
The project has resulted in three developed concepts that could potentially broaden the existing longboard market as well as a band of ideas that could be used for inspiration of future projects.
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Tatičová, Lucia. "Relaunch značky Physiogel na českom a slovenskom trhu." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-162718.
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A new product launch is important and difficult part of product life cycle. It also means uneasy process for company. Goal of this diploma thesis is to evaluate chosen marketing mix strategy of relaunch Physiogel on Czech and Slovak market through marketing plan conduct and realization of marketing research focusing on target group. Theoretical part offers basics for better understanding of the topic. Then practical part, consists from two phases, offering conduct of marketing plan and structure, analysis of marketing research and evaluation of results. Output from these activities will consist not only from analysis and evaluation of marketing mix strategy, but also enrichment of information concerning target group and proposal of marketing activities for the brand for year 2014.
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Hua, Xiaoqin [Verfasser], and Sonja [Akademischer Betreuer] Schrepfer. "Identifying New Targets, Developing Novel Models, and Investigating Innovative Strategies for the Treatment of Rejection in Thoracic Transplantation / Xiaoqin Hua. Betreuer: Sonja Schrepfer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1030365601/34.
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Orgler, Christina [Verfasser], and Angelika [Akademischer Betreuer] Vollmar. "The potential to identify and explore innovative anticancer targets by using the natural products Vioprolide A and Lagunamide A / Christina Orgler ; Betreuer: Angelika Vollmar." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1199816647/34.
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Shpilka, Tetyana. "Návrh a implementace systému Innovation Scorecard za účelem měření úspěchu inovace ve společnosti Red Hat." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2020. http://www.nusl.cz/ntk/nusl-417397.
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Tato diplomová práce představuje návrh a implementaci řídicího systému známého jako Innovation Scorecard, který byl zaveden a aplikován v rámci společnosti Red Hat Czech s.r.o. Účelem bylo vylepšení současného modu operandi společnosti se zvláštním důrazem na zlepšení vývoje a implementačních procesů softwaru. Hlavní zaměření práce je především na měření toho, jak úspěšný byl jakýkoli navrhovaný inovativní způsob práce. Diplomová práce je rozdělena do tří částí. První část obsahuje základní znalosti, které jsou důležité pro pochopení konkrétního tématu výzkumu. Druhá část diplomové práce popisuje společnost a umožňuje tak pochopení interních procesů a systémů v rámci firmy. Třetí část obsahuje související návrhy, jak zlepšit vnitřní procesy. To je založeno na analýze s hlavním zaměřením na to, jak společnost v současné době funguje.
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Bowerman, Kamra. "An Investigation of Boaters' Attitudes toward and Usage of Targeted Mobile Apps." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5607.
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The purpose of this study was to understand boaters' adoption and usage of smartphones and mobile apps as well as to obtain their opinion on potential features of a targeted mobile app being developed as part of a broader interdisciplinary Florida Sea Grant outreach project. Data were gathered from an online survey of a sample of 164 boaters from the surrounding Central Florida area. In contrast with previous empirical mobile app studies, many respondents reported using mobile apps for information-seeking versus escape gratifications. Further more than half of the respondents' age sixty-five and over indicated using smartphones and mobile apps. These findings reflected recent national trend data showing shifting gratifications and an increase in technology use among older American adults. In regards to the planned mobile app, the study's respondents had favorable reactions to its potential features and indicated an above average intent toward downloading the app.M.A.
Masters
Communication
Sciences
Communication; Mass Communication
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Федишин, Ірина Богданівна, Ирина Богдановна Федишин, and I. B. Fedyshyn. "Інноваційний розвиток промислових підприємств в умовах нестабільної економіки." Thesis, Тернопільський національний технічний університет ім. Івана Пулюя, 2012. http://elartu.tntu.edu.ua/handle/123456789/1922.
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Робота виконана у Тернопільському національному технічному університеті імені Івана Пулюя Міністерства освіти і науки, молоді та спорту України.Захист відбувся «28» грудня 2012 р. об 1100 годині на засіданні спеціалізованої вченої ради К 58.052.05 у Тернопільському національному технічному університеті імені Івана Пулюя за адресою: 46008, м. Тернопіль,
вул. Білогірська, 2, зал засідань.
З дисертацією можна ознайомитись у бібліотеці Тернопільського національного технічного університету імені Івана Пулюя за адресою: 46001,
м. Тернопіль, вул. Руська, 56.Дисертація присвячена науковому обґрунтуванню та оптимізації теоретичних та методичних положень, а також практичних рекомендацій щодо організаційно-економічного забезпечення інноваційного розвитку промислових підприємств в умовах нестабільної економіки. У роботі проведено дослідження концепції інновації, закономірностей та еволюції основних понять, пов’язаних з інноваційною діяльністю; здійснено аналіз світових та вітчизняних тенденцій діяльності промислових підприємств та подано оцінку стану інноваційного розвитку промислових підприємств регіону. Здійснено прогнозування тенденцій розвитку промислових підприємств на інноваційній основі. Запропоновано методику розробки цільових комплексних інноваційних програм, що передбачає оцінку і вибір наукових проблем для програмного вирішення, аналіз кон’юнктури ринку, формування комплексу цілей, розробку попереднього і розгорнутого проекту програми, визначення організаційно-економічного механізму управління формуванням і реалізацією наукової цільової програми.
Диссертация посвящена научному обоснованию и оптимизации теоретических и методических положений, а также практических рекомендаций по организационно-экономическому обеспечению инновационного развития промышленных предприятий в условиях нестабильной экономики. В работе проведено исследование концепции инновации, закономерностей и эволюции основных понятий, связанных с инновационной деятельностью; осуществлен анализ мировых и отечественных тенденций деятельности промышленных предприятий и дана оценка состояния инновационного развития промышленных предприятий региона. Осуществлено прогнозирование тенденций развития промышленных предприятий на инновационной основе. Предложена методика разработки целевых комплексных инновационных программ, что предусматривает оценку и выбор научных проблем для программного решения, анализ конъюнктуры рынка, формирование комплекса целей, разработку предварительного и развернутого проекта программы, определение организационно-экономического механизма управления формированием и реализацией научной целевой программы.
The thesis is devoted to the scientific grounding and optimization of theoretical and methodological principles, and practical recommendations for organizational and economic support of industrial enterprises innovative development in unstable economy. The paper studies the concept of innovation, patterns and evolution of basic concepts related to innovation, analyzes global and national tendencies of industrial activities and assesses present condition of innovative development of regional industrial enterprises. Prognosis of industrial enterprises innovation development tendencies are made. The notion of economic instability is specified and is understood in this study as being imbalanced through exogenous and endogenous factors. Credit limitation, downfall of prices and demand on industrial production that took place particularly in the years 2008-2009 crisis has shaken the economic development of the country and provoked the decline of industry. In conditions of economic instability with the aim to improve implementation of innovation by industrial enterprises the use of target programming is suggested. Method of target programming is a way of solving large and complex problems, such as the development of innovative strategies for enterprise, industry. A detailed study of industrial enterprises leads to the conclusion that they are characterized by low innovation activity, low rates of reproduction processes and, consequently, high rates of depreciation, unprofitable production. The analysis of enterprises innovation financing sources witnesses that the dominant source of such financing are own funds and state investment. Analysis of the law of Ukraine on regulation of innovation development and its comparison with the legislation of CIS countries indicates its fragmentary nature, which manifests itself in regulation and coordination of certain areas of innovation development and in use of some leverage with those used in the world. A method of target complex innovative programs design which provide assessment and selection of scientific problems for software solutions, analysis of market conditions, complex targets modeling, development of preliminary and detailed project applications, organizational and economic mechanism formation and implementation of targeted research programs is suggested. The technique will ensure efficient and on time development of target complex innovative programs, program implementation and operation, will allow to solve the problem of enterprise`s and region`s development direction in optimum terms with minimal costs.
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Höfle, Ursula [Verfasser]. "Immunhistochemische Untersuchungen von Plattenepithelkarzinomen der Mundhöhle und des Oropharynx in Hinblick auf Anwendungsmöglichkeiten einer innovativen zielgerichteten Therapie ("targeted therapy") / Ursula Höfle." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023697424/34.
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Dumas, Guillaume. "La gestion des résultats des entreprises innovantes." Thesis, Toulouse 1, 2014. http://www.theses.fr/2014TOU10039/document.
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Cette thèse s’intéresse à la gestion des résultats dans le cadre des entreprises innovantes. Elle est constituée de trois articles. Dans le premier, il s’agit d’examiner si les résultats des entreprises innovantes sont gérés et si le stade de développement des innovations influence cette gestion des résultats. Il apparaît que les résultats des entreprises innovantes sont gérés à la hausse. Cette gestion ne semble intervenir qu’au cours de l’activité d’innovation (c’est-à-dire lorsque les entreprises investissent en R&D) ; l’achèvement des innovations n’incitant pas les dirigeants à gérer les résultats. Partant de ce constat, nous nous demandons dans le deuxième article si (i) la comptabilisation des dépenses de R&D est utilisée comme une modalité de GR ou (ii) si l’activation de ces dépenses est une information comptable fiable. Nos résultats montrent que les dépenses de R&D sont activées pour gérer les résultats et plus précisément pour atteindre des résultats cibles. L’activation des dépenses de R&D est une information comptable fiable uniquement lorsque les dirigeants ne sont pas incités à atteindre des résultats cibles. Enfin, dans le troisième article, nous observons si les dirigeants des entreprises innovantes utilisent l’ajustement des dépenses de R&D en plus de leur activation pour atteindre les résultats cibles. Il apparaît que ces deux modalités de GR sont utilisées conjointement pour atteindre le bénéfice et les prévisions de résultat des analystes. En revanche, pour éviter une diminution du résultat, les dépenses de R&D sont soit ajustées soit activéesThis thesis deals with earnings management in the context of innovative companies. It consists in three articles. In the first, we examine whether the earnings of innovative firms are managed and if the stage of development of innovations influences this earnings management. Results show that the results of innovative firms are managed upward. This earnings management seems to occur only during innovative activity (i.e. when firms invest in R&D); the completion of innovations not incenting to manage earnings.Based on this observation, in the second article, we wonder whether (i) R&D expenditures are capitalized in order to manage earnings or (ii) whether the capitalization of these expenditures is reliable accounting information. Our results show that R&D expenses are capitalized in order to manage earnings and more precisely to meet earnings targets. R&D capitalization is reliable only when managers have no incentive to achieve earnings targets. Finally, in the third article, we examine whether managers use jointly the adjustment of R&D expenditures and their capitalization in order to beat earnings targets. Results show that managers use these two earnings management techniques to beat zero earnings and analysts earnings forecasts. However, R&D expenses are either capitalized or reduced to avoid a decrease of earnings
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Kramer, Iris [Verfasser]. "Nutritargeting : Development and Investigation of an Innovative Carrier System for the Targeted Delivery of alpha-Tocopherol and Lutein in vitro / Iris Kramer." Aachen : Shaker, 2005. http://d-nb.info/1186575956/34.
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Guard, Misty Ann. "Business innovation and regulatory enforcement: case studies of the big box retail industry and enforcement of RCRA." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33940.
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The purpose of this research is to examine the following research question: how has enforcement of Resource Conservation and Recovery Act (RCRA) adapted to the Big Box business system innovation? Additionally, the study explored the possible nature of regulatory choke points that may emerge from the enforcement of RCRA in the Big Box retail system. This study used contingency theory to establish a foundation for analysis of the Big Box business system innovation through identification of structural elements, external influences, and their subsequent interactions associated with the Big Box retail system in terms of environmental compliance with the RCRA enforced by the United States (US) Environmental Protection Agency (EPA). This research employed an embedded comparative case study design using the comparison of two Big Box firms, Walmart Stores, Inc. and Target Corporation, nationally and for the following states with opposing enforcement strategies: Arizona, Kentucky, Missouri, and Texas. The data used was obtained from third-party federal or firm-maintained sources.
Findings indicate Walmart adheres to the structural models developed using contingency theory principles and incurs more impacts from regulatory agencies due to the enforcement of RCRA. Furthermore, it was observed that inspections of the firms are not distributed throughout the organizational structural elements by all states. Additionally, the use of different enforcement strategies resulted in the emergence of regulatory choke points by Arizona, Kentucky, and Texas; however, Missouri appears to balance enforcement without causing a regulatory choke point.
This research has identified that the enforcement of RCRA has not universally adapted to the demands of the Big Box business system innovation. Agency implications, firm implications, directions for further research, and continued development of a regulatory choke point theory are discussed.
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Gifu, Elena Patricia. "Emergence of cancer stem cells in the early stages of hepatic carcinogenesis and development of innovative models of hepatocellular carcinoma." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1319/document.
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Le carcinome hépatocellulaire est un grand problème de santé publique et la troisième de mortalité lié au cancer dans le monde. Il a été démontré qu'au sein des tumeurs se trouve un petite population des cellules cancéreuses avec des propriétés de cellules souches cancéreuses. Elles sont responsables de l'initiation des tumeurs ainsi que de la récidive post-traitement et résistance aux thérapies. Peu de choses sont connues par rapport à la biologie de ces cellules mais l'identification des facteurs favorisant leur existence pourrait conduire vers des nouvelles pistes thérapeutiques.Nous avons trouvé que le facteurs de transcription p73 est surexprimé chez les patients dans les tumeurs du carcinome hépatocellulaire sous forme de deux types d'isoformes, les isoformes complets et les isoformes tronqués. Les isoformes complets sont des suppresseurs de tumeurs et corrèlent avec un meilleur taux de survie alors que les isoformes tronqués agissent comme dominants négatifs de ces premiers et favorisent la récidive post-chirurgie.Les résultats in vitro ont montré que les isoformes tronqués de p73 sont surexprimés dans les cellules souches cancéreuses du carcinome hépatocellulaire et favorisent leur emergenceHepatocellular carcinoma (HCC) is a major public health problem, being the second most lethal cancer with an increasing incidence around the world. The only approved systemic drug is the multikinase inhibitor Sorafenib, which prolongs patients’ survival by only three months. HCC is refractory to known chemotherapeutic drugs and more than 50% of patients relapse after surgical tumor removal. These phenomena are thought to be due to the existence of a population of poorly differentiated cancer cells, largely known as liver cancer stem cells (CSCs). Recent studies revealed that CSCs activate similar pathways as normal stem cells. They are therefore highly resistant to therapies and are thought to be capable of self-renewal and generation of tumor’s heterogeneous cell mass. The understanding of mechanisms proper to liver CSCs should allow the development of innovative drugs with original mechanism of action against liver CSC, likely to improve patients’ outcome. However, the development of new therapies against HCC is penalized by the limited number of experimental models.According to these current challenges in the field of HCC research, my PhD thesis project covers three main axes: Development of novel models of disease (IMODI consortium)The Innovative Models of Disease (IMODI) consortium is mainly dedicated to the development of innovative experimental models for 7 different types of cancer. Our participation to the project concerned 3 main objectives i) development of HCC patient-derived xenografts ii) development of new HCC cell lines and iii) set up a cryoconservation method of primary human hepatocytes (PHHs) in the aim to employ them in humanizing murine livers. 30 patients planned for HCC tumor resection were recruited and their clinicopathological data were collected. Fresh tumor specimens were subcutaneously xenografted in immune-deficient mice and dissociated for in-vitro tumor cell culture. One tumor led to the development of a moderately differentiated HCC PDX model, as confirmed by histological characterization. Several studies showed the importance of PDX models in drug discovery as they recapitulate the drug-sensitivity patterns seen in patients from which they derive but very few models have been described in the literature for HCC. In vitro, primary HCC cells could be maintained in culture for a limited period of time, in average 30 days. No HCC cell lines developed due to cells entering replicative senescence, as previously described
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hellman, Joakim, and Alexander Björklund. "Co-living och fastighetsföretagens strategier." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23099.
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Bakgrund: Urbaniseringen som har skett under lång tid har skapat en stor bostadsbrist i svenska stora städer. I takt med att hållbarhet och miljö har blivit allt viktigare, har detta lett till att företag och marknaden har fått upp intresse för delningsekonomi ochnya boendeformer. Paralleller kan dras mellan det nya fenomenet co-living och de kollektivboenden som växte fram redan på 60- och 70-talet där människor med liknande intressen bodde tillsammans. Boendeformen co-living har fått mycket uppmärksamhet de senaste åren då den är yteffektiv, ekonomisk och mer social än traditionella hyresrätter. Fastighetsföretagens incitament för att investera i detta kan vara av olika anledningar och det är därför intressant att undersöka vilken strategi de har när de väljer att involvera sig i co-living.Syfte: Arbetet syftar till att undersöka vilken strategisk roll co-living har för fastighetsföretagen? För att kunna besvara syftet har det brutits ned till följande frågeställningar:- Varför investerar fastighetsföretag i co-living?- Hur bedrivs co-living?- Vad krävs för att bedriva co-living?Metod: Arbetet är utformat som en kvalitativ studie där empiriinsamling skett genom semistrukturerade intervjuer.Resultat: Det som har framkommit i arbetet är att fastighetsföretagens strategi inom co-living varierar. Intresset för co-living är stort i Sverige och det visade sig att företagen ser möjligheter i att utöka och bredda variationen i sitt utbud av boendeformer samt att behålla sina kunder inom företaget. Företagens interna förmågor och resurser har visat sig vara viktiga vid valet av strategi vid co-living. Företag som anser sig besitta rätt kunskaper väljer att starta co-living i egen regi, medan ett företag i studien ansåg att det var en bättre strategi att bli delägare i ett annat ledande företag inom co-living och på så sätt få in rätt kunskaper. Vidare visade det sig att företagen såg co-living som ett sätt att hitta nya innovativa produkter och tjänster till sin organisation.Background: The urbanization that has taken place for a long time has created a majorhousing shortage in big cities in Sweden. As sustainability and the environment havebecome increasingly important, this has led to a gained interest in sharing economy andin new forms of housing from the market and the real estate companies. Parallels canbe observed between the new phenomenon co-living and the collectiveaccommodations that emerged in the 1960s and 70s where people with similar interestslived together. Co-living is a form of housing that has received a lot of attention inrecent years as it is surface efficient, economical and includes more social interactionsthan in traditional rental properties. Real estate companies’ incentives to invest in thissegment can be manifested in different ways. Therefore, it is interesting to investigatewhat strategy they use when choosing to involve themselves in co-living.Purpose: The study aims to examine what strategic role co-living plays for the real estate companies? In order to answer the purpose, it has been broken down in to three issues:- Why does real estate companies invest in co-living?- How is co-living conducted?- What does it require to conduct co-living?Methodology: The study was conducted as a qualitative examination where data is gathered through semi-structured interviews.Conclusion: What has emerged in the study is that the real estate companies' strategy in co-living varies. Interest in co-living is great in Sweden and it turns out that companies see opportunities in expanding and broadening the variety in their range of housing types and in keeping their customers within the company. The companies' internal capabilities and resources have proven to be important factors when deciding a strategy for investment in co-living. Companies that consider themselves to have the right capabilities and resources choose to start co-living on their own, while one company in the study thought it was a better strategy to become part-owner of another leading co-living company and thus gain the right knowledge. Furthermore, it turned out that the companies saw co-living as a way to find new innovative products and services for their organization.
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Kratzer, Jan, and Christopher Lettl. "Distinctive Roles of Lead Users and Opinion Leaders in the Social Networks of Schoolchildren." University of Chicago Press, 2009. http://dx.doi.org/10.1086/599324.
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Prior research has shown that both lead users and opinion leaders may propel the diffusion of innovation. This raises the question of whether lead users and opinion leaders are positioned similarly in social networks, which we address using a sample of 23 school classes consisting of 537 children. Research among children is very scarce in this particular domain. Our statistical analyses based on hierarchical linear modeling reveal two general results: first, lead users among children appear to possess a variety of links between clusters; second, opinion leaders are locally positioned within clusters of children and have many direct links. (authors' abstract)
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Drápalíková, Jitka. "Návrh podnikového trainee programu a jeho zavedení pomocí technik projektového managementu v organizaci." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2021. http://www.nusl.cz/ntk/nusl-444615.
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Burman, Anna-Karin. "An Idea Is a Life Form : An attempt to find evidence of the Conceptual MetaphorTheory by studying the Old English poem Beowulf." Thesis, Högskolan i Halmstad, Sektionen för humaniora (HUM), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-24265.
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This small study concerns occurrences of metaphor, metonymy and conceptual metaphor in the Old English poem Beowulf. The first 224 lines of Beowulf were searched for non-literal passages. Thefound passages were sorted into the groups conventionalized metaphor, metonymy and innovativemetaphor. The conceptual metaphors were in turn sorted into target domains and source domains and grouped within the domains. These were then compared to Modern English and Modern Swedish metaphors and conceptual metaphors with the help of dictionaries and corpus studies. Beowulf was also looked at as a small corpus. Words which were suspected to be used inmetaphorical senses were searched for in the full text and the results were examined and comparedwith modern language usage. It was found evident that Old English and Modern English, as well as Modern Swedish, have many conceptual metaphors in common both when in comes to experiential metaphors and culturally grounded metaphors.
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N'Guessan, Cécilia. "La phosphatase PPM9 de Plasmodium : caractérisation moléculaire et fonctionnelle, structure 3D du site catalytique et découverte de nouvelles molécules antipaludiques." Thesis, Lille, 2020. http://www.theses.fr/2020LILUS033.
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Le paludisme est l’une des maladies infectieuses les plus répandues à travers le monde. En 2018, cette parasitose fut responsable de 405 000 morts. RTS, S/A01, le seul vaccin testé à grande échelle, ne remplit pas à ce jour tous les critères d’efficacité exigés. Plasmodium falciparum (Pf), l’espèce responsable de la plus forte mortalité, a développé des résistances contre quasi tout l’arsenal thérapeutique. Il est crucial d’approfondir nos connaissances sur la biologie de ce parasite, en vue de découvrir de nouveaux médicaments. Chez Pf, de nombreuses études ont montré que les kinases et les phosphatases jouent un rôle crucial pour la survie du parasite. L’étude du kinome a permis de mettre en lumière que cibler les kinases pouvait représenter une stratégie intéressante dans le traitement de la maladie. Toutefois, les phosphatases de Pf restent peu étudiées. Des analyses comparatives des séquences en acides aminés, réalisées chez P. berghei (Pb), espèce spécifique des rongeurs, ont révélé que 6 d’entre elles sont spécifiques du genre Plasmodium. Parmi ces phosphatases, la métallophosphatase 9 (PPM9) une sérine thréonine phosphatase spécifique de Plasmodium, semble être essentielle dans le développement des stades érythrocytaires du parasite. Le gène a également été identifié comme étant essentiel chez Pf, grâce à une méthode de mutagénèse saturante à haut débit. Notre projet a pour objectif la caractérisation moléculaire et fonctionnelle de PPM9 et la validation de cette phosphatase spécifique de Plasmodium, en tant que nouvelle cible potentielle pour le paludisme. Le gène a été cloné, annoté, exprimé sous forme de protéine recombinante et sa fonction phosphatase caractérisée. L’activité enzymatique de PfPPM9 recombinante a été standardisée au sein du test au Malachite Green et nous avons montré qu’elle était dépendante de l’ion manganèse. La caractérisation fonctionnelle, a été explorée via la construction de lignées knock-out conditionnelles mais également des lignées parasitaires knock-in pour suivre leur trafic tout au long du cycle de vie (chez Pf et Pb). Nous avons en effet montré une localisation principalement cytoplasmique de PPM9 et suggéré un export possible dans le cytoplasme de l’hématie. Par ailleurs, parmi ces études de génétique inverse, nous avons notamment employé la technologie CRISPR-Cas9 facilitant l’utilisation de la Cre recombinase dimérisable (diCre) qui permet d’exciser une séquence d’ADN flanquée par des sites loxP, après activation de la rapamycine. Enfin, nous avons déterminé une structure 3D putative de PfPPM9 par homologie comparative afin d’identifier in silico des inhibiteurs spécifiques de son site actif. Un criblage virtuel a ainsi été réalisé avec la database ZINC15 et celle de L’ICPAL sur notre structure 3D. Environ 80 composés ont été testés pour leur activité antipaludique in vitro. Trois hits ont été mis en évidence : M19, M51 et M74. M19 possède une concentration inhibant 50% de la croissance parasitaire (CI50) de 3,87 μM +/- 0,25 et une structure originale jamais encore décrite comme composé antipaludique. De plus, via des études en RMN (Waterlogsy et CPMG), nous avons montré une interaction spécifique de ces hits avec PfPPM9. En perspective, l’intéractome de PPM9 devrait permettre de déterminer ses partenaires/cibles protéiques chez le parasite. En conclusion, ce projet nous conduira à une meilleure compréhension du rôle de PPM9 dans le développement du parasite et la découverte de nouvelles molécules antipaludiquesMalaria today is one of the wide spread infectious diseases in the world. In 2018, 405 000 malaria deaths have been reported. RTS, S/A01 the only vaccine tested on a large scale does not fulfil its promises with a lack of efficiency. Plasmodium falciparum (Pf), the deadliest agent of malaria, has developed resistances to almost all chemotherapeutics. It is necessary to understand the biology of this parasite in order to develop new drugs. In Pf, extensive research has now been started to study the Pf kinome and to examine whether targeting kinases could represent an effective mean for the treatment of the infection, the study of its phosphatome is still under-investigated. Amino acid sequence comparative analyses of Plasmodium berghei (Pb), a rodent malaria species, revealed that 6 are Plasmodium specific. Among these phosphatases, the metalloprotein phosphatase 9 (PPM9), a Plasmodium specific serine/threonine phosphatase, was also suggested to be essential for blood stage parasites development. Besides in a high-throughput saturation mutagenesis method in Pf, PPM9 gene was also identified essential. The present project is focused on the molecular and functional characterization of the PPM9 and on the validation of this specific phosphatase as a new potential target for malaria. The gene has been cloned, annotated and expressed as a recombinant protein and its phosphatase function has been characterized. The enzymatic activity of PfPPM9 recombinant protein has been standardised using a malachite green phosphate assay kit and this activity is manganese dependant. Functional characterization was explored by conditional gene knock-out studies as well as by generating knock-in parasite lines to follow their trafficking during the parasite lifecycle (in Pf and Pb). PfPPM9 seems to be mainly localised in the parasite cytoplasm and could be exported in the cytoplasm of red blood cell. Among these studies, we employ CRISPR-Cas9 in Pf to facilitate use of the dimerisable Cre-recombinase (diCre) that is used to mediate the excision and loss of loxP-flanked DNA sequences in a rapamycin-controlled manner. Finally, we solved in silico the 3D structure of PfPPM9 by homology modelling and identified a new set of potential specific inhibitors. We screened in silico ZINC15 database and ICPAL base on the 3D structure. We have tested around 80 compounds for their anti-plasmodial in vitro activity. We have highlighted 3 hits: M19, M51 and M74. M19 has a half maximal inhibitory concentration (IC50) of 3,87 μM +/- 0,25 and a unique scaffold as antimalarial compound. Besides, via NMR studies (Waterlogsy and CPMG), we have shown a specific interaction between these hits and PfPPM9. As a perspective, PPM9 interactome will be carried out to determine its target/partner proteins in the parasite. In conclusion, this study will lead to a deeper understanding of the role of PPM9 in the parasite development and the discovery of new antimalarial compounds
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Poret, Arnaud. "Modélisation qualitative des réseaux biologiques pour l'innovation thérapeutique." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10090/document.
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Cette thèse est consacrée à la modélisation qualitative des réseaux biologiques pour l'innovation thérapeutique. Elle étudie comment utiliser les réseaux Booléens, et comment les améliorer, afin d'identifier des cibles thérapeutiques au moyen d'approches in silico. Elle se compose de deux travaux : i) un algorithme exploitant les attracteurs des réseaux Booléens pour l'identification in silico de cibles dans des modèles Booléens de réseaux biologiques pathologiquement perturbés, et ii) une amélioration des réseaux Booléens dans leur capacité à modéliser la dynamique des réseaux biologiques grâce à l'utilisation des opérateurs de la logique floue et grâce au réglage des arrêtes. L'identification de cibles constitue l'une des étapes de la découverte de nouveaux médicaments et a pour but d'identifier des biomolécules dont la fonction devrait être thérapeutiquement modifiée afin de lutter contre la pathologie considérée. Le premier travail de cette thèse propose un algorithme pour l'identification in silico de cibles par l'exploitation des attracteurs des réseaux Booléens. Il suppose que les attracteurs des systèmes dynamiques, tel que les réseaux Booléens, correspondent aux phénotypes produits par le système biologique modélisé. Sous cette hypothèse, et étant donné un réseau Booléen modélisant une physiopathologie, l'algorithme identifie des combinaisons de cibles capables de supprimer les attracteurs associés aux phénotypes pathologiques. L'algorithme est testé sur un modèle Booléen du cycle cellulaire arborant une inactivation constitutive de la protéine du rétinoblastome, tel que constaté dans de nombreux cancers, tandis que ses applications sont illustrées sur un modèle Booléen de l'anémie de Fanconi. Les résultats montrent que l'algorithme est à même de retourner des combinaisons de cibles capables de supprimer les attracteurs associés aux phénotypes pathologiques, et donc qu'il réussit l'identification in silico de cibles proposée. En revanche, comme tout résultat in silico, il y a un pont à franchir entre théorie et pratique, requérant ainsi une utilisation conjointe d'approches expérimentales. Toutefois, il est escompté que l'algorithme présente un intérêt pour l'identification de cibles, notamment par l'exploitation du faible coût des approches computationnelles, ainsi que de leur pouvoir prédictif, afin d'optimiser l'efficience d'expérimentations coûteuses. La modélisation quantitative en biologie systémique peut s'avérer difficile en raison de la rareté des détails quantitatifs concernant les phénomènes biologiques, particulièrement à l'échelle subcellulaire, l'échelle où les médicaments interagissent avec leurs cibles. Une alternative permettant de contourner cette difficulté est la modélisation qualitative étant donné que celle-ci ne requiert que peu ou pas d'informations quantitatives. Parmi les méthodes de modélisation qualitative, les réseaux Booléens en sont l'une des plus populaires. Cependant, les modèles Booléens autorisent leurs variables à n'être évaluées qu'à vrai ou faux, ce qui peut apparaître trop simpliste lorsque des processus biologiques sont modélisés. En conséquence, le second travail de cette thèse propose une méthode de modélisation dérivée des réseaux Booléens où les opérateurs de la logique floue sont utilisés et où les arrêtes peuvent être réglées. Les opérateurs de la logique floue permettent aux variables d'être continues, et ainsi d'être plus finement évaluées qu'avec des méthodes de modélisation discrètes tel que les réseaux Booléens, tout en demeurant qualitatives. De plus, dans le but de considérer le fait que certaines interactions peuvent être plus lentes et/ou plus faibles que d'autres, l'état des arrêtes est calculé afin de moduler en vitesse et en force le signal qu'elles véhiculent. La méthode proposée est illustrée par son implémentation sur un petit échantillon de la signalisation du récepteur au facteur de croissance épidermique... [etc]This thesis is devoted to the qualitative modeling of biological networks for therapeutic innovation. It investigates how to use the Boolean network formalism, and how to enhance it, for identifying therapeutic targets through in silico approaches. It is composed of two works: i) an algorithm using Boolean network attractors for in silico target identification in Boolean models of pathologically disturbed biological networks, and ii) an enhancement of the Boolean network formalism in modeling the dynamics of biological networks through the incorporation of fuzzy operators and edge tuning. Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology. The first work of this thesis proposes an algorithm for in silico target identification using Boolean network attractors. It assumes that attractors of dynamical systems, such as Boolean networks, correspond to phenotypes produced by the modeled biological system. Under this assumption, and given a Boolean network modeling a pathophysiology, the algorithm identifies target combinations able to remove attractors associated with pathological phenotypes. It is tested on a Boolean model of the mammalian cell cycle bearing a constitutive inactivation of the retinoblastoma protein, as seen in cancers, and its applications are illustrated on a Boolean model of Fanconi anemia. The results show that the algorithm returns target combinations able to remove attractors associated with pathological phenotypes and then succeeds in performing the proposed in silico target identification. However, as with any in silico evidence, there is a bridge to cross between theory and practice, thus requiring it to be used in combination with wet lab experiments. Nevertheless, it is expected that the algorithm is of interest for target identification, notably by exploiting the inexpensiveness and predictive power of computational approaches to optimize the efficiency of costly wet lab experiments. Quantitative modeling in systems biology can be difficult due to the scarcity of quantitative details about biological phenomenons, especially at the subcellular scale, the scale where drugs interact with there targets. An alternative to escape this difficulty is qualitative modeling since it requires few to no quantitative information. Among the qualitative modeling approaches, the Boolean network formalism is one of the most popular. However, Boolean models allow variables to be valued at only true or false, which can appear too simplistic when modeling biological processes. Consequently, the second work of this thesis proposes a modeling approach derived from Boolean networks where fuzzy operators are used and where edges are tuned. Fuzzy operators allow variables to be continuous and then to be more finely valued than with discrete modeling approaches, such as Boolean networks, while remaining qualitative. Moreover, to consider that some interactions are slower and/or weaker relative to other ones, edge states are computed in order to modulate in speed and strength the signal they convey. The proposed formalism is illustrated through its implementation on a tiny sample of the epidermal growth factor receptor signaling pathway. The obtained simulations show that continuous results are produced, thus allowing finer analysis, and that modulating the signal conveyed by the edges allows their tuning according to knowledge about the modeled interactions, thus incorporating more knowledge. The proposed modeling approach is expected to bring enhancements in the ability of qualitative models to simulate the dynamics of biological networks while not requiring quantitative information. The main prospect of this thesis is to use the proposed enhancement of Boolean networks to build a version of the algorithm based on continuous dynamical systems...[etc]
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Guigue, Lisa. "Evaluation clinique de la pression artérielle centrale à partir de la mesure par cathétérisme radial en utilisant la modélisation de l'arbre artériel, de la liaison hydraulique et du capteur. Intégration de la fonction dans un dispositif de surveillance de la qualité de la mesure de la pression artérielle." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS036.
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La pression centrale est le reflet de l'état hémodynamique du patient et son estimation se fait par l'acquisition de la pression artérielle radiale plus facilement accessible chez la majorité des patients en anesthésie-réanimation et soins intensifs. Cette thèse tente de résoudre les difficultés de l’évaluation de la pression centrale à partir du cathétérisme radial associé à un capteur de pression via une liaison hydraulique. Ces freins à l'évaluation sont :1.les altérations liées à la liaison hydraulique entre le cathéter radial et le capteur;2.les distorsions liées à l’arbre artériel entre le cœur et la périphérie (artère radiale). Il existe des cas cliniques où les propriétés de l’arbre artériel sont modifiées de telle sorte que la pression périphérique n’est plus le reflet de la pression centrale et donc ne peut plus l'estimer correctement. L'un de ces phénomènes est connu sous le terme de découplage entre pressions artérielles centrale et périphérique.Pour la première difficulté, le dispositif médical CAThétérisme Artériel Radial en Soins Intensifs (CATARSI) développé par AII Biomédical apporte une solution à ce problème en fournissant un indice de la qualité de la mesure par cathéter et liaison hydraulique.Dans les cas physiopathologiques entraînant une mauvaise estimation de la PA central, la possibilité d’alerter le personnel soignant sur l’apparition de ces situations serait optimale. Cette fonction pourrait être intégrée au dispositif CATARSI. Au préalable, il faut comprendre, évaluer et modéliser de manière précoce, les mécanismes mis en jeu dans ces situations cliniques particulières.Le travail de thèse s'articule donc selon 3 axes :1.Evaluation expérimentale, par oscillométrie et cathétérisme, de la mesure de la vitesse de propagation de l’onde de pouls le long de l’arbre artériel chez l’homme (Pression artérielle centrale, radiale, fémorale) en situation de découplage entre pression centrale/pression périphérique. Cette évaluation sera faite chez des patients en CEC (Circulation Extra-Corporelle) car ils peuvent présenter des découplages. Plusieurs phases de mesures sont prévues avant, pendant et après la CEC.2.Recherche et optimisation d’une méthode de détection automatique du découplage entre pression artérielle centrale et périphérique à partir de l’analyse du signal de pression radiale en continu et d’une mesure complémentaire effectuée par le clinicien avec un autre capteur sur proposition du dispositif CATARSI.3.Proposition d’un ou plusieurs modèles du segment central-radial de l’arbre artériel afin d’obtenir une meilleure évaluation de la pression artérielle centrale à partir de la mesure de pression radiale par cathéter pour ensuite intégrer de nouvelles fonctionnalités dans le dispositif CATARSIAortic pressure is generally recognized as a good index of the hemodynamic state of a patient. In intensive care units, aortic pressure is indirectly estimated via a radial catheter-tansducer system. The present study aims to remove the obstacles to a reliable evaluation of central pressure via the radial catheter-transducer system commonly used in clinics. These obstacles can be due to :1.technical problems occurring between the radial catheter and the sensor;}2.pathophysiological problems affecting the arterial tree between the heart and peripheral arteries. Several clinical situations have been identified in which alterations of the physical properties of the vasculature do not allow a reliable estimation of central arterial pressure using the common radial setting. One of these phenomena is the so called central-to-radial arterial pressure gradient.CATARSI, a medical device developped by AII SAS, affords a solution to the first group of problems by providing an index of the quality of the signal provided by the radial catheter-transducer system.Under pathophysiological conditions affecting the arterial vascualture of the patient, early detection of a mismatch between peripheral and central arterial pressure would also be of great clinical value. In this view, a new functionality could be develop to implement CATARSI. However, to achieve this goal, it is first necessary to understand, evaluate and modelize the precise pathophysiological mechanisms involved in these particular situations.The study contains three steps :1.Experimental evaluation, by oscillometry and catheterization, of AP propagation-time on the human arterial tree (aortic, radial, femoral arterial pressure) during a central-to-radial arterial pressure gradient. This evaluation has been carried out on patients undergoing Cardio Pulmonary Bypass (CPB). Several measurements have been performed: before, during and after CPB.2.Development and optimization of a method allowing the detection of an uncoupling between central and peripheral arterial pressure thanks to AP signal analysis in real time and a potential complementary measurement performed with CATARSI.3.Several central to radial arterial modelling propositions in order to present a better evaluation of central arterial pressure estimated by radial arterial pressure
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Зикіна, М. С. "Шляхи вдосконалення рекламно-інформаційної діяльності туристичного підприємства-оператора (за матеріалами туристичного оператора «Coral Travel Ukraine»)." Thesis, Одеський національний економічний університет, 2020. http://dspace.oneu.edu.ua/jspui/handle/123456789/12699.
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У роботі розглядаються теоретико-методологічні основи розвитку рекламно-інформаційної діяльності в туризмі, розкривається суть функції та класифікація рекламної діяльності. Проведено аналіз діяльності туристичного підприємства оператора «Coral Travel Ukraine», зокрема його рекламну політику, та вплив рекламної і інформаційної діяльності на рівень розвитку підприємства. Визначено сучасні напрямки та перспективи вдосконалення рекламної діяльності підприємства оператора «Coral Travel Ukraine». В роботі запропоновані заходи спрямовані на вдосконалення рекламно-інформаційної діяльності туристичних підприємств-операторів, та проведено аналіз їх ефективності.The the work considers with the theoretical and methodological foundations of advertising and information activities in tourism, The essence of the function and classification of advertising activities is revealed. The analysis of the activities of the tourist company operator "Coral Travel Ukraine", in particular its advertising policy, and the impact of advertising and information activities on the level of development of the company. The current directions and prospects of improving the advertising activities of the operator's enterprise "Coral Travel Ukraine". In the paper we propose measures aimed at improving the advertising and information activities of tourism enterprises-operators, and analyzes their effectiveness.
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KUO, CHIH-CHUN, and 郭芷君. "Target Users’ Context:The Contextual Source of Products Innovation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/sx2ruh.
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碩士東吳大學
企業管理學系
107
Taking users as the source of innovation become key issues for R&D in these days. As more and more enterprises build mechanisms to learn from users, such as inviting online users or having design thinking workshops; this research suggests enterprises to engage into the users’ contexts to know the local knowledge of users’ behaviors. Theoretically, this research contributes to user-centric innovation literatures and redefines the meaning of effectuation. As prior research suggests “effectuation” as taking innovators’ prior knowledge to be the source of innovation; this research suggests users’ local knowledge is another source of innovation. For example, innovators may take “Xian Cao” as drinks, tea eggs, jelly and other forms of products; in this case, innovators could also take the Xian Cao drinks into different users’ context and come up with multiple business models, such as taking it as healthy drinks in Malaysia while being the party drinks in Canada. This research also contributes to business model innovation and suggests the importance of social values instead of economic values for products and services. Besides, this research suggests the “critical mass” as the source of innovation and should become part of R&D practices, including learning from users’ local knowledge, curating with local languages, and educating with local scenarios. Practically, this research suggests enterprises to dedicate to investigate users’ contextual needs, value-creation process, and cross-boundary innovation. In this way, enterprises could build systematic R&D mechanism and innovate continuously.
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Chen, Yi-Chun, and 陳怡鈞. "Effects of target costing on business model innovation and firm performance." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/06712294703963419344.
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碩士國立高雄應用科技大學
商務經營研究所
99
The purpose of this study is to investigate how manufacturing firms can influence their business model innovation and firm performance through the implementation of target costing practices. Using a data set from 170 manufacturing firms sampled from electronics and information industries in China, the SEM results clearly indicate that target costing practices improve business model innovation and firm performance. In addition, the result suggests that business model innovation strengthens firm performance. Moreover, this paper offers a contribution to the current literature by adding empirical evidence from high-tech firms on the role of target costing in the business model innovation.
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Wu, Kang-Chun, and 吳康君. "IT - enabled Marketing Target Customers Innovation：A CHT Case Study." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/jx537m.
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碩士國立中山大學
高階經營碩士班
103
After the government has allowed privatized telecom companies to operate in Taiwan, Telecom industry has gradually become a red ocean battleground. Due to the fact that the customer base is limited (the max number of customers is basically the whole human population of Taiwan), it’s a huge troublesome for the marketing department to find the target customers for the appropriate campaigns/promotions, within the allowed time frame and budget. This research paper is based on how information technology (IT) can help to increase the efficiency of marketing people targeting the right customers within a given time frame and promotion goals, with the aid of a case study showing how the marketing department of a fix line broadband company greatly decrease the time of finding the precise customers after IT steps in. This paper will explain how IT, by first reviewing marketing people’s requirements, then using a systematic method, build-up a data model to fulfill these requirements and also build-up a best practice for data gathering and data cleansing, help to solve the issues of disperse Data Mart within the company. Then, using the commonly used pivot table interface, the marketing people will then be able to pick out the targeting customers within the shortest amount of time. The practice that is demonstrated within this paper should not only apply to this selective company, it should also be applicable to all industries &; corporations with large customer base. I believe the methodology that is mentioned in this paper.
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Gu, Sue-Chiou, and 古素秋. "The Target Market Research on Innovative Products-A study of UMPC." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/84427728789521554092.
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碩士元智大學
管理研究所
96
The Internet has made possible entirely new forms of human social interaction, and with emerging technology, mobile Internet devices represent a unique productivity enhancement opportunity. Current handheld mobile computers are being pushed to their practical performance limits in a response to growing user demand for more content–rich applications. As Categories of mobile devices converge, the ultra-mobile PC ( UMPC ) is one of the primary types of productivity tools. To determine which market segment is UMPC’s target market, this research commissioned a survey to test attitudes, perceptions and product function feature expectations. Based upon the preferences of the respondents, this information is meant to provide any participant in the mobile device marketplace the reference data for better product revision.
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Serrão, Christophe Barros. "Simultaneously binding to multiple cell surface targets in innovative strategy to delivery anti-tumor drugs." Master's thesis, 2013. http://hdl.handle.net/10451/34403.
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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2013As ligações multivalentes consistem em interacções simultâneas da mesma natureza entre vários receptores e ligandos. Este tipo de ligação permite uma resposta quantitativamente e qualitativamente diferente da que seria obtida com uma ligação monovalente. Após revisão de vários estudos na área, é incontestável que este tipo de ligações poderá vir a se tornar numa estratégia cada vez mais interessante na busca de ligações mais específicas. As terapias anti-tumorais são terapias muito tóxicas que requerem um máximo de especificidade de forma minimizar os esfeitos adversos. Como tal, nesta revisão bibliográfica esta estratégia da interacção multivalente for abordada como tentativa de produzir terapêuticas anti-tumorais mais específicas. Após análise de vários estudos foi concluído que, por existir elevada sob-expressão de determinados antigénios e receptores à superfície das células tumorais, as interacções multivalentes apresentam-se como bons inibidores dos tumores quer como veículo para direcionamento e libertação de fármacos anti-tumorais no local de acção ou como inibidor directo de determinados receptores alvo.
Multivalent interactions are defined by the formation of several simultaneous interactions of the same nature between the ligand and the receptor. This type of binding is translated into a different response in both quantitative and qualitative matters than the response that we would obtain from a monovalent interaction. After reviewing several studies made in this area, it’s undeniable that this type of strategy is very promising for the research of more specific receptor binding. Anti-tumoral therapies are very toxic therapies that need to be very specific to the targeted cells in order of minimizing side effects in healthy cells. In this review, we apply the multivalent interaction into the anti-tumoral therapies in attempt to minimize the side effects. After analysis of several studies, we conclude that because the receptors and other antigens in targeted cells are over expressed, multivalent interactions can be an interesting strategy to fight cancer trough direct inhibitions of the multivalent ligands or by serving as a carrier for a pro-drugs that is only released into the tumor cells.
Faculté de Pharmacie - Institut des Sciences Pharmaceutiques et Biologiques de l'Université Claude Bernard Lyon 1
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Macedo, Rui Pedro da Silva Ferreira. "Cell wall rhamnosylation: an original target for innovative antimicrobial strategies against Listeria monocytogenes." Master's thesis, 2021. https://hdl.handle.net/10216/137581.
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Hun, Chien-Min, and 洪健閔. "The main mechanism’s weight target research of the Technological Innovation Procedure – The Taiwan FPD as an example." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/bcudr3.
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碩士國立臺北科技大學
電資碩士班
100
Flat Panel Display (FPD) industry, the characteristics of capital-intensive, technology-intensive, short product life cycles, technological change speed production line, more than the number of patents, international division of labor in general, and easier in the fluctuating price of non-steady balance, this study aims to provide for Taiwan FPD industry, the main mechanism of technological innovation process weight indicators, a view to provide Taiwan FDP industry technology innovators an objective assessment of the operation target, and adjust as technological innovation, technological innovation, when the operating staff mode of reference, further bulwark for the FPD industry, when faced with patent reference. This study is through product development model, technology innovation management, and intellectual property management system for the three literature research and discussion, and to make technological innovation management system. Taiwan FDP industry-related R&D personnel as a research object, by amending the Modified Delphi Method analysis and to establish a technology innovation management system as the primary mechanism of the process of project evaluation indicators, and use the Analytic Network Process (ANP) evaluation indicators for the breakdown of the importance of the weight distribution. The results showed that " Innovated Technical Value," the proportion of 44.33%, for the operation of technical innovation at the most important part, and in all the elements of technological innovation " Patent Apply or Publish," in technical innovation and technical personnel the importance of time of up to 20.00%, thus view to provide R&D personnel engaged in the operation of technological innovation when innovation modelling reference.
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Bogalho, Ana Beatriz dos Santos. "Innovative therapeutic approaches to fight glioblastoma." Master's thesis, 2019. http://hdl.handle.net/10451/43342.
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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019O glioblastoma é um tumor agressivo do sistema nervoso central, com sobrevivência limitada e reduzidas opções de tratamento. A terapia standard consiste na ressecção cirúrgica seguida de radioterapia e quimioterapia com Temozolomida (TMZ). Doentes com glioblastoma têm uma diminuída esperança de vida e mesmo após tratamento, a recorrência do tumor é quase certa. Investigação tem sido feita para se descobrir novas terapias que possam melhorar o tratamento standard e o prognóstico. Com os avanços da ciência, as terapias pioneiras compreendem as terapias dirigidas, imunoterapia, viroterapia, terapia génica, entre outras. As terapias dirigidas consideram os vários mecanismos que o tumor usa para crescer e sobreviver, tais como o mecanismo do recetor tirosina-cinase/ fosfatidilinositol-3-cinase/ proteína cinase ativada por mitogénios (RTK/PI3K/MAPK), mecanismo da proteína 53 (p53) e o mecanismo da proteína retinoblastoma (pRb), bem como outros importantes mecanismos de sinalização celular, como o mecanismo da poliamina biosintética. Com o conhecimento de quais as proteínas e genes que contribuem para a proliferação tumoral, pode-se usar o mesmo para sinalizar as células tumorais e restringir o crescimento do tumor. A imunoterapia usa o sistema imunitário do doente para combater o tumor e inclui as terapias com células CAR-T, terapia TIL e terapia TCR, vacinação e inibição dos checkpoints imunitários. A viroterapia usa a atividade oncolítica do vírus para sinalizar as células tumorais e destruí-las. A terapia génica insere, modifica ou inativa um gene de forma a combater o tumor. Adicionalmente, existem outras diferentes terapias a serem investigadas, que consideram outros mecanismos, como o metabolismo do colesterol e a hipertermia. Como o glioblastoma é uma doença fatal, mais opções de tratamento são necessárias para melhorar a qualidade de vida e a sobrevivência destes doentes. O objetivo desta dissertação é analisar o futuro das terapias contra o glioblastoma, olhando para as inovações nas abordagens terapêuticas que se encontram em desenvolvimento. Embora estas novas terapias pareçam promissoras para definir um novo tratamento, existem certas dificuldades adjacentes ao próprio tumor, ao sistema nervoso central e ao desenho dos ensaios clínicos que são um grande desafio e serão posteriormente discutidos.
Glioblastoma is an aggressive tumour of the central nervous system, with limited survival and poor treatment options. The standard therapy consists of surgical resection followed by radiation therapy and chemotherapy with Temozolomide (TMZ). Patients with glioblastoma have a low life expectancy and even after treatment, recurrence is almost certain. Research its being made to find new therapies that can improve the standard treatment and prognosis. With the advances of science, the pioneering therapies comprise targeted therapies, immunotherapy, virotherapy, gene therapy, among others. Targeted therapies consider the many pathways that tumour uses to grow and survive, such as receptor tyrosine kinase/phosphoinositide 3-kinasen/mitogen-activated protein Kinase (RTK/PI3K/MAPK) pathway, p53 and retinoblastoma protein (pRb) pathways, and other important signalling transduction pathways, such as polyamine biosynthetic pathway. With the knowledge of which proteins and genes contribute to the proliferation of the tumour, that information can be used to target the cancer cells and restrain the glioblastoma growth. The immunotherapy uses the immune system of the patient as a pathway to fight the tumour and includes CAR-T cells therapy, TIL therapy, TCR therapy, vaccination and immune checkpoint inhibition. The virotherapy uses the oncolytic activity of the virus to target the tumour cells and destroy them. Gene therapy inserts, modifies or inactivates a gene in order to fight the disease. Additionally, there are other different therapies being investigated, that consider other mechanisms, such as the cholesterol metabolism and hyperthermia. Since glioblastoma is a fatal disease, more options for treatment are needed to improve quality of life and the overall survival of the patients. The purpose of this dissertation is to analyse the future of glioblastoma treatments, looking to the innovative therapeutic approaches that are under development Although these new therapies, look promising to assemble a new treatment, issues related to the tumour itself, to the central nervous system and to clinical trials design are a huge challenge that will be further discussed.
Estágio em Farmácia Hospitalar realizado na Azienda ospedaliera “Ospedali Riuniti Villa Sofia-Cervello”; Estágio em Farmácia Comunitária realizado na Farmácia Segurado
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Tain, Fu-lian, and 田福連. "The research of school innovative management target construction and an evaluation tool of innovative management influencing factor—an elementary school for example." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/77079267892626274161.
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博士國立臺南大學
教育經營與管理研究所博士班
98
The purpose of this article is studying the developing of school innovative management target construction. It means developing evaluation tool of influencing factor of weight target of the localization school innovation management. Hope it can provide the educational administration and the educational staffs a correct and effective evaluation standard of the innovative management influencing factors, and establishing the bidirectional feedback mechanism and the promotion of the innovation work, the connotation and the strategy quality. Then creates the school organization achievements, the construction of high efficient education quality, promotes the people cultural accomplishment and the national competitive power
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Krishnan, Sabapathy Giridhar Suren. "Innovating surgery for oral squamous cell carcinoma with targeted fluorescent and magnetic tracers." Thesis, 2022. https://hdl.handle.net/2440/135953.
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Oral squamous cell carcinoma (OSCC) is characterised by its locally aggressive nature and its high propensity to metastasise to regional lymph nodes (LN)s. It is well-established that margin status and the presence of LN metastases are two of the most important factors affecting prognosis. While patient and tumour factors cannot be changed after presentation, margin control during primary tumour resection and staging of the clinically occult neck are two components of treatment that are within the control of the head and neck surgeon. Despite this, positive margin rates have not improved over the last three decades and staging of the clinically negative neck continues to rely on elective neck dissection (END), which results in overtreatment of up to 75% of patients. Molecular imaging, with tracers designed to target specific tissue and tumour ligands, is a growing field that has significant potential to improve outcomes for patients with OSCC. This thesis evaluates how two different tracer technologies could be used to aid either margin assessment during resection of the primary tumour, and/or staging of the clinically negative neck with sentinel lymph node biopsy (SLNB). The tracers studied within this thesis are Panitumumab-IRDye800CW, an EGFR-targeting fluorophore used for fluorescence molecular imaging, and FerroTrace, a superparamagnetic iron oxide nanoparticle (SPION) that has been engineered with mannose end targets for macrophage-specific binding to aid SLNB.Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2022
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Danielsson, David. "A study of how hospital libraries can view the patients as a target audience." Thesis, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-21363.
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The study examines how hospital libraries view patients as a target audience and their usage of the library’s analogue and digital collections, as well as what functions hospital libraries can perform for patients. There is a knowledge gap in the literature regarding the way that hospital libraries have viewed and formed relationships with the patients. The theory emphasizes relationships between the library and its user groups. The method for gathering empirical data was mainly qualitative semi-structured interviewing, which were conducted with the head of the library, a nurse and a voluntary staff, as well as qualitative content analysis of the webpage and policy document. The analysis of the empirical data and theories concluded that in a relationship marketing context the patient group corresponded to the customer market place, the nurse to the referral market and the voluntary staff to the influencer market, making the connection between the library and the customer market heavily relying on other markets in the model by Payne et al. (2005). The digital collections have mostly been built with the hospital staff in mind with the aim of aiding evidence-based health care. There is a lack of knowledge among the patients about the library’s existence and services. A potential is the patients’ own technological devices in reaching the library’s website and interacting with the staff. The hospital library has a “dually empowering effect”, referring to the physical space as a calm place to relax and finding literature in relevant fields. The aim is normalization of the patient. The lacking of resources calls for innovation, relationship building and collaboration between the parties in order for the library to reach the patients, here relationship marketing has potential.
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Chen, Chung-Kuang, and 陳重光. "The Comparison Study on Effect of Organizational Culture to Electronic Engineer’s Innovation Ability—Using Cross-Strait Information Electronic Industry as Target." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/4beyg9.
Full textAbstract:
碩士中國文化大學
國際企業管理研究所
97
Complicated and competitive business marketing environment is the both the result and cause of globalization and advancing technology. For limited resources, small to medium-sized companies, being continuously innovative in technology is one of the best strategies to stay competitive in the business. The goal of this research is trying to find out how the business organization, with the “inherent factor”— personality specialty and “external factor”— organization culture, influences personnel innovativeness. Totally 569 valid questionnaires are collected, analyzed and used to conclude this study. In which, 275 questionnaires are collected from Taiwan and 294 from mainland China. Most survey candidates are electronics engineers from the information technology industry. With statistical analysis on each variant, this study advises that both properly adapting the organization culture to the business environment and as well as hiring individuals with organization culture senses in mind are the most effective way for the business to strengthen staffing engineers’ innovativeness.
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Pinheiro, Bernardo Lobo Vilela da Silveira. "Millennials as an adequate target for disruptive mobile banking apps : Montepio case." Master's thesis, 2018. http://hdl.handle.net/10400.14/25521.
Full textAbstract:
Nowadays, society is relentlessly moving towards an increasingly digitalized panorama where the banking industry is expected to continue playing an invaluable role. In the aftermath of a crisis period that brought great turmoil to European markets, banks were submitted to stricter regulation and tighter capital requirements that have deeply influenced their operations.
Recently, there have been legislative reforms within the European community that will ultimately open the door to non-traditional financial institutions that wish to operate in the banking sector. This is the case of technological start-ups that are specialized in financial services, such as FinTech companies – currently marketing their innovative mobile banking apps in several countries across a growingly digitalized world.
Many traditional retail banks are already accelerating the pace, in a race against Time, reshaping business models to provide the modern consumer with a disruptive banking experience. This Thesis proposes Millennials as an appropriate segment for financial institutions to target, in order to successfully implement their mobile banking applications.
By combining the knowledge gathered from academic literature and the results obtained via a thorough assessment on 195 Millennials that have answered an online questionnaire, the researcher endeavours to define if this generation is indeed an adequate target and how should mobile banking apps be designed and marketed, considering the characteristics of this final consumer.Actualmente, a sociedade caminha vagarosamente no sentido de um panorama cada vez mais digital, onde se espera que a indústria bancária continue a ter um papel inestimável. Após um período de crise que trouxe grande turbulência aos mercados europeus, os bancos foram submetidos a regulação mais rigorosa e a restrições de capital mais apertadas que influenciaram profundamente as suas operações. Recentemente, tiveram lugar reformas legislativas na comunidade europeia que vêm abrir a porta a instituições financeiras não-tradicionais que pretendem exercer actividade no sector bancário. É o caso de start-ups tecnológicas especializadas em serviços financeiros, como as FinTech – que estão a lançar aplicações bancárias inovadoras em vários países num mundo cada vez mais digitalizado. Vários bancos de retalho têm vindo a acelerar o ritmo, numa corrida contra o Tempo, reformulando modelos de negócio para propiciar ao consumidor moderno uma experiência bancária disruptiva. Esta Tese propõe os Millennials como um segmento apropriado para que as instituições financeiras implementem aplicações bancárias com sucesso. Através de uma combinação de conhecimentos que derivam da literatura académica e dos resultados obtidos através de uma avaliação minuciosa sobre 195 Millennials que responderam a um questionário online, o autor procura definir se esta geração é um alvo adequado, bem como de que forma as aplicações bancárias devem ser desenhadas e comercializadas, considerando as características do consumidor final.
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LIN, SING-CUEI, and 林杏翠. "The impact of technological relatedness between acquiring firm and target firm on rival firms' Innovation performance：The moderating effects of acquirers' Alliance Experience and Absorptive Capacity." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/92b98r.
Full textAbstract:
碩士國立高雄應用科技大學
企業管理系
104
This study empirically examines the relationship between Technological relatedness between acquiring firm and target firm on rival firms' innovation performance, and investigates the influence of moderators which include strategic alliance experience and absorptive capacity factors on it. This paper adopts the acquirer’s M&A events of Taiwanese high-tech industry from 1998 to 2013 as the sample. The empirical results show that the technological relatedness between acquiring firm and target firm on rival firms' innovation performance is U-type of non-linear relationship. The argument of the influence of prior alliance was not found in this study. The absorptive capacity would accentuate the technological relatedness between the acquiring firm and the target firm on rival firms' innovation performance.
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Joshi, Anusuya. "Community-based waste management strategies in relation to a targeted Nepalese community." Thesis, 2015. https://vuir.vu.edu.au/31003/.
Full textAbstract:
The Bagmati River, which is of great cultural and religious importance to the Nepalese people, is also a major water resource. Its degradation, as a result of urbanization and industrialization, affects water quality and poses a threat to the environment and to human health - as well as resulting in water scarcity. In particular, the discharge of sewage directly into the river without prior treatment contributes significantly to river water pollution, whereas municipal solid waste dumping onto the river bank and development activities are major contributors to the deteriorating situation of the river basin overall. This study addresses this problem from a number of perspectives including an examination of two appropriate community-based technologies that may contribute to the sustainable management of domestic waste and sewage and that will also minimize the impact on the surrounding environment, especially the Bagmati River. Thus an existing composting method, the Takakura Composting Method (TCM), for municipal solid waste management was scientifically investigated with a view to optimizing its current performance. Vermifiltration (VF), which exploits earthworm metabolism to remove contaminants from sewage effluent, was also scientifically investigated in order to develop its potential for treating domestic sewage at the community level. Also investigated is the potential for both of these technologies to be integrated into the community for resource recovery.
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Zornes, Deborah. "The business of the university: research, its place in the 'business', and the role of the university in society." Thesis, 2012. http://hdl.handle.net/1828/4249.
Full textAbstract:
Neoliberal ideologies have been adopted through most of the developed world. In North America, they dominate and provide the backdrop for the way decisions are made, organisations are governed, and policies are considered and implemented. Universities have not been exempt from the pressures of neoliberalism and increasingly are becoming what is being referred to as ‘corporatised’.
Using a multi-institutional ethnographic case study, drawing on elements of institutional ethnography and using discourse analysis and interviews, this research focused on these topics with four research intensive universities in British Columbia: UBC, UNBC, UVic and SFU. This research sought to answer the question: In what ways is corporatisation visible in the practices and discourses related to university research in British Columbia, and, in turn, what impacts are being felt?
The findings from the research indicated that there is, as might be expected, strong support for post-secondary education. The rhetoric in the documents from the universities and governments shows a ‘grand vision’ for education as the cornerstone of a successful society. The findings confirm that universities are viewed internally and externally as important and that, in turn, research and discovery is paramount. However, what the research also showed was that there are differing views among those in power regarding how that vision plays out. Those differences can be summarized as: citizen preparation versus job training; social innovation versus commercial innovation; targeted research (both in the type of research carried out and to what ends); and the level of autonomy of the university. These tensions can be considered through the theoretical frameworks that guided the research: commodification (i.e., of education and research); resource dependence theory; and institutional theory.
Universities are increasingly being corporatised and this is visible in: increased oversight and control by governments with regard to the direction of the university, both from an educational and research perspective; an emphasis on the fiscal bottom line; increased accountability requirements (in complexity and frequency) related to funding for educational programs and research; increased demands for, and focus on, demonstrable impacts and quantifiable measures from research; a reduced amount of collegial governance; increased bureaucracy; and pressures to adopt business models, practices, and processes from the private sector.Graduate
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Tretter, Benjamin. "The luxury watch industry : a market opportunity analysis for collectID." Master's thesis, 2021. http://hdl.handle.net/10400.14/35732.
Full textAbstract:
CollectID is a Swiss startup providing a technology that solves the problem of counterfeits while offering a new channel for digital brand interaction by combining physical products with a digital environment to create a so-called phygital product experience. Since collectID was not able to identify an appropriate target market where its value propositions meet real customer needs from a B2B- and a B2C-perspective, this thesis analyses the luxury watch industry as a potential target market for collectID using three research approaches. Firstly, interviews with representatives of luxury watch brands revealed that some customer segments are having needs for both of collectID’s value propositions. Furthermore, even though these companies are not well digitized yet, there are innovators in the market. Secondly, a consumer survey revealed four distinct consumer segments. However, while consumers have a real need for digital brand interaction, they do not do so regarding authenticity. Thirdly, interviews with the team of col-lectID showed that the company should mainly target collector’s brands and innovators.
Finally, managerial implications were derived based on the findings of this study and further existing research on target market selection. As a final recommendation, this thesis concludes that collectID should not target the luxury watch industry since it does not meet real customer demands from a B2C-perspective.CollectID é uma startup suíça que fornece uma tecnologia que resolve o problema de falsificações, ao mesmo tempo que oferece um novo canal para interação digital de marca, combinando produtos físicos com um ambiente digital para criar a chamada experiência de produto phygital. Uma vez que o collectID não foi capaz de identificar um mercado-alvo apropriado onde suas propostas de valor atendam às necessidades reais do cliente de uma perspectiva B2B e B2C, esta tese analisa a indústria de relógios de luxo como um mercado-alvo potencial para o collectID usando três abordagens de pesquisa. Em primeiro lugar, entrevistas com representantes de marcas de relógios de luxo revelaram que alguns segmentos de clientes estão tendo necessidades para ambas as propostas de valor do collectID. Além disso, embora essas empresas ainda não estejam bem digitalizadas, há inovadores no mercado. Em segundo lugar, uma pesquisa com consumidores revelou quatro segmentos de consumidores distintos. No entanto, embora os consumidores tenham uma necessidade real de interação com a marca digital, eles não o fazem em relação à autenticidade. Em terceiro lugar, as entrevistas com a equipe do collectID mostraram que a empresa deve visar principalmente as marcas de colecionadores e inovadores. As implicações gerenciais foram derivadas com base nas conclusões deste estudo e outras pesquisas existentes sobre a seleção do mercado-alvo. Como recomendação final, esta tese conclui que o collectID não deve ter como alvo a indústria de relógios de luxo, uma vez que não atende às demandas reais dos clientes de uma perspectiva B2C.
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Brejo, João Miguel Faustino. "Equity research - Dimpomar, Lda.: case study." Master's thesis, 2018. http://hdl.handle.net/10071/18654.
Full textAbstract:
The purpose of this thesis is to assess the value of Dimpomar, a privately owned company.
In order to reach reasonable results and perform the valuation, the theoretical background
was first presented regarding the several valuation methods, followed by a company
presentation, industry analysis and the analysis of the financial indicators and situation of
the company.
The valuation methods used in order to reach the enterprise value, firm value, equity value
and price per share value were the Discounted Cash Flow and the Relative Valuation
(Multiples). The fact that these two methods were applied, allowed the comparison of
Dimpomar with the peer group, having more arguments to justify the obtained value of
Dimpomar, which was an enterprise value of 13,784,962€ and a price target of 177.4€.
To conclude, this work provides a solid base of analysis for a possible exit through an
IPO (initial public offer).Esta tese tem como objetivo avaliar a Dimpomar, Lda., empresa não cotada. De modo a obter um resultado sensato e efetuar a avaliação, numa primeira fase foram apresentados os conceitos e fórmulas teóricos relativamente aos diferentes métodos de avaliação, seguidos por uma apresentação da empresa, análise do setor e análise dos indicadores e situação financeira da empresa. Os métodos de avaliação usados de modo a chegar ao valor da empresa, valor da firma, valor do capital próprio e valor das ações foram os do discounted cash flow e o método de avaliação por múltiplos (relative valuation). O facto de ambos os métodos terem sido aplicados, permitiu comparar a Dimpomar com o grupo de pares, e desta forma ter mais argumentos que justifiquem o valor da avaliação obtido da mesma. O valor da empresa final obtido foi de 13,784,962€ e o preço por ação de 177.04€. Para concluir, este trabalho providencia uma base sólida de análise para o lançamento de uma possível OPA.