Journal articles on the topic 'INML'
To see the other types of publications on this topic, follow the link: INML.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'INML.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Deichmann, Nicholas. "Theoretical Basis for the Observed Break inML/MwScaling between Small and Large Earthquakes." Bulletin of the Seismological Society of America 107, no. 2 (February 28, 2017): 505–20. http://dx.doi.org/10.1785/0120160318.
Full text
2
Vieira, Duarte Nuno. "Forensic Medicine And Forensic Sciences in Portugal." Bulletin of Legal Medicine 14, no. 1 (April 1, 2009): 40–47. http://dx.doi.org/10.17986/blm.2009141689.
Full textAbstract:
The first legal texts to contain any rules relating forensic medicine expertises in Portugal date back to the 16th century. But the qualitative leap that actually allowed Portuguese Forensic Medicine to develop, bringing it to the stage where it is today, only occurred three centuries later, in the 19th century. Indeed, the first university teaching of forensic medicine appeared in 1836, with independent courses bearing this title, and in 1899 the first official forensic medical services were set up. A number of changes took place thereafter, and throughout the 20th century, always serving to improve the system. They culminated in a thorough reorganisation of the entire framework of forensic medicine in Portugal in the transition from the 20th to the 21st century, more exactly in 2000/1001. This consisted of unifying the Portuguese forensic medical services in a single National Institute of Legal (Forensic) Medicine (“Instituto Nacional de Medicina Legal” - INML). In the following pages we shall concentrate particularly on the present situation of forensic medicine and other forensic sciences in Portugal and on the glimmering future prospects.
3
Patil, S. L., P. K. Mishra, M. N. Ramesha, and S. K. N. Math. "Response of Sunflower to Rainwater Conservation and Nutrient Management in Semi-arid Conditions." Helia 38, no. 63 (December 1, 2015): 253–68. http://dx.doi.org/10.1515/helia-2014-0044.
Full textAbstract:
AbstractSunflower is an important oilseed crop grown throughout the year due to its short duration, day neutral, low photoperiod sensitivity and wider adoptability to agroclimatic conditions and soil types in Asian countries. Lower yields of sunflower in rainfed vertisols are attributed to lower soil moisture and nutrients availability. In this situation, we conducted field studies at research farm and farmers’ fields to know the response of sunflower to rainwater conservation and nutrient management in vertisols of India. Compartmental bunding and ridges and furrows conserved more rainwater in profile, thus producing greater sunflower seed yields varying from 22% to 28% compared to farmers’ practice of flat-bed sowing. Greater seed yield with resource conservation is attributed to higher head diameter with greater head weight and seed weight per plant over flat-bed sowing. Nutrient management as farmers practice INM1 (15 kg N ha−1 + 15 kg P2O5 ha−1 + 1.0 t farmyard manure ha−1) with Azospirillum seed treatment (INM2) produced 5–6% higher seed yield, whereas recommended rate of nutrients (40 kg N ha−1 + 40 kg P2O5 ha−1 + 2.0 t farmyard manure ha−1) with Azospirillum seed treatment (INM3) produced 13–16% greater seed yield both at research farm and farmers’ fields over INM1.
4
IKRAM, M., SHAZIA JABEEN, and M. SAEED. "HYSTERECTOMY." Professional Medical Journal 19, no. 02 (February 22, 2012): 214–21. http://dx.doi.org/10.29309/tpmj/2012.19.02.2015.
Full textAbstract:
Abdominal hysterectomy, the procedure by which almost 90% of hysterectomies are currently being done. Laparoscopicassisted vaginal hysterectomy has been introduced as an alternative to abdominal hysterectomy, and is thought to allow a more rapid return tonormal activity. Laparoscopic assisted vaginal hysterectomy has less postoperative morbidity and quicker recovery than abdominalhysterectomy. Objective: To compare the laparoscopic assisted vaginal hysterectomy with total abdominal hysterectomy in term of operativetime, per operative blood loss and post-operative wound infection. Study Design: Randomized trial. Setting: This study was carried out in thedepartment of obstetrics and gynaecology, Shaikh Zayed Hospital, Lahore. Period: Six months (15th September, 2008 to 15th March 2009).Patients and methods: Eighty patients fulfilling the inclusion criteria were selected for this study. Patients were equally divided in two groups;group A (laparoscopic assisted vaginal hysterectomy) and group B (total abdominal hysterectomy). Operative time (in minutes), blood loss (inml) as estimated and post-operative wound infection was assessed by presence or absence of wound discharge, redness and edema aroundthe incision on 3rd, 5th and 7th post-operative day. Results: The mean ages of women in group A was 49.13+4.26 and 45.68+4.54 years ingroup B. The maximum number of parity between 3-4 was 19 in group A and 20 in group B. Mean weights of cases in group A was 65.60+10.45kilograms and 70.77+15.59 kilograms in groups B. The per-operative time in group A was 105.13+6.55 minutes and 83.38+14.82 minutes ingroup B. The mean blood loss in group A was 178.0+43.51 ml and 228.25+72.49 ml in group B. The wound discharge was not found in group A,while in group B, 4 cases (10%) on 3rd post-operative day, 6 cases (15%) on 5th post-operative day and 11 cases 27.5% on 7th post-operative.Conclusions: Laparoscopic assisted vaginal hysterectomy has a quicker post-operative recovery but at the expense of a bit long duration ofsurgery. Laparoscopic vaginal assisted hysterectomy is a feasible option in a selected group of patients who would otherwise require anabdominal hysterectomy. The drug requirement to control pain and level of pain experienced by patients were also significantly less.
5
Iordache, Elena Lelia, Anamaria Avram, and Crina Julieta Sinescu. "Aortic ring abscess." Romanian Journal of Infectious Diseases 18, no. 2-3 (September 30, 2015): 114–17. http://dx.doi.org/10.37897/rjid.2015.2-3.11.
Full textAbstract:
Introduction. Cardiac abscess is a severe complication of aortic valve endocarditis. The aortic valve ring is more commonly affected than mitral valve ring. Materials and methods. We report the case of a patient admitted to the cardiology clinic, evaluated, diagnosed and later transferred to the Infectious Disease Clinic for treatment. Results. We present the case of a patient of 72 years old, hospitalized in the cardiology clinic with symptoms and signs of heart failure. After clinical and laboratory data, it was diagnosed infective endocarditis on bicuspid aortic valve and abscess aortic ring evacuated. The patient was transferred to the infectious diseases clinic for antibiotic treatment. Conclusions. It is a complex case with multidisciplinary approach, and aortic ring abscess is a poor prognostic factor.
6
ALTAŞ, Ayşe Başak, Fatma BAYRAKDAR, and Gülay KORUKLUOĞLU. "Infl uenza Surveillance in Five Consecutive Seasons During Post Pandemic Period: Results from National Infl uenza Center, Turkey." Mikrobiyoloji Bulteni 50, no. 3 (July 29, 2016): 401–17. http://dx.doi.org/10.5578/mb.27775.
Full text
7
Hernández Lorenzo, Laura. "INMA CUESTA EN SU FILMOGRAFÍA." Revista Internacional de Culturas y Literaturas 19, no. 19 (2016): 118–28. http://dx.doi.org/10.12795/ricl.2016.i19.10.
Full text
8
ÖZÖZEN AYAS, Zeynep, and Ayhan BÖLÜK. "Stroke Presenting with Pure Hiccup: Case Report." Turkiye Klinikleri Journal of Case Reports 25, no. 1 (2017): 19–22. http://dx.doi.org/10.5336/caserep.2016-51968.
Full text
9
IMPERIALE, B. R., R. D. MOYANO, A. B. DI GIULIO, M. A. ROMERO, M. F. ALVARADO PINEDO, M. P. SANTANGELO, G. E. TRAVERÍA, N. S. MORCILLO, and M. I. ROMANO. "Genetic diversity ofMycobacterium aviumcomplex strains isolated in Argentina by MIRU-VNTR." Epidemiology and Infection 145, no. 7 (February 7, 2017): 1382–91. http://dx.doi.org/10.1017/s0950268817000139.
Full textAbstract:
SUMMARYMycobacterium aviumsp.avium(MAA),M. aviumsp.hominissuis(MAH), andM. aviumsp.paratuberculosis(MAP) are the main members of theM. aviumcomplex (MAC) causing diseases in several hosts. The aim of this study was to describe the genetic diversity of MAC isolated from different hosts. Twenty-six MAH and 61 MAP isolates were recovered from humans and cattle, respectively. GenoType CM®and IS1311-PCR were used to identifyMycobacteriumspecies. The IS901-PCR was used to differentiate between MAH and MAA, while IS900-PCR was used to identify MAP. Genotyping was performed using a mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) scheme (loci: 292, X3, 25, 47, 3, 7, 10, 32) and patterns (INMV) were assigned according to the MAC-INMV database (http://mac-inmv.tours.inra.fr/). Twenty-two (22/26, 84·6%) MAH isolates were genotyped and 16 were grouped into the following, INMV 92, INMV 121, INMV 97, INMV 103, INMV 50, and INMV 40. The loci X3 and 25 showed the largest diversity (D: 0·5844), and the global discriminatory index (Hunter and Gaston discriminatory index, HGDI) was 0·9300. MAP (100%) isolates were grouped into INMV 1, INMV 2, INMV 11, INMV 8, and INMV 5. The HGDI was 0·6984 and loci 292 and 7 had the largestD(0·6980 and 0·5050). MAH presented a higherDwhen compared with MAP. The MIRU-VNTR was a useful tool to describe the genetic diversity of both MAH and MAP as well as to identify six new MAH patterns that were conveniently reported to the MAC-INMV database. It was also demonstrated that, in the geographical region studied, human MAC cases were produced by MAH as there was no MAA found among the human clinical samples.
10
KELLE DİKBAŞ, Şerife, Işıl KALYONCU ASLAN, and Cem NAZİKOĞLU. "Morbidity and Mortality in Decompression Surgery After Acute Ischemic Stroke." Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 11, no. 3 (September 27, 2022): 1121–28. http://dx.doi.org/10.37989/gumussagbil.944785.
Full textAbstract:
İnme, dünya çapında ikinci ölüm ve yetişkinlerde edinilmiş engelliliğin en yaygın nedenidir. Bu çalışmanın amacı, inme merkezinde akut iskemik inme nedeniyle takip edilen ve progressif serebral beyin ödemi sebebiyle dekompresif cerrahi uygulanan hastalarda morbidite ve mortalite ile ilişkili faktörleri incelemektir. Çalışmanın örneklemini Ocak 2017-Aralık 2019 tarihleri arasında dekompresif cerrahi yapılan 17 hasta oluşturdu. Hastaların demografik ve klinik verileri retrospektif olarak incelendi. Hastaların yaş ortalaması 57,59±13,77’ idi. Dokuz (%53) hastanın yaşı 60’dan küçüktü. Hastaların akut inme tedavisi öncesi Ulusal Sağlık İnme Ölçeği puan ortalaması 14,18±3,66’ idi. Tedavi sonrası Ulusal Sağlık İnme Ölçeği puan ortalaması ise 11,12±4,5olarak bulundu. Tedavi ile Ulusal Sağlık İnme Ölçeği puanındaki düşüş istatistiksel olarak anlamlıydı (p
11
Seifried, Teresa M., Paul Bieber, Laura Felgitsch, Julian Vlasich, Florian Reyzek, David G. Schmale III, and Hinrich Grothe. "Surfaces of silver birch (<i>Betula pendula</i>) are sources of biological ice nuclei: in vivo and in situ investigations." Biogeosciences 17, no. 22 (November 20, 2020): 5655–67. http://dx.doi.org/10.5194/bg-17-5655-2020.
Full textAbstract:
Abstract. Silver birch (Betula pendula) is known to contain ice-nucleating macromolecules (INMs) to survive in harsh environments. However, little is known about the release and transport of INMs from birch trees into the atmosphere. In this study, we conducted in situ and in vivo investigations on INMs from nine birches growing in an alpine valley (Ötztal, Austria). A detailed analysis of drill cores showed that INM concentration increases towards outer layers, reaching its maximum near the surface. Aqueous extracts from the surfaces of leaves, bark, primary wood and secondary wood contained INMs (34∕36) with concentrations ranging from 9.9×105 to 1.8×109 INMs cm−2. In a field study, we analysed the effect of precipitation on the release of these INMs attached to the surface of the trees. These experiments showed that INMs are splashed and aerosolized into the environment during rainfall events, at concentrations and freezing temperatures similar to in vivo samples. Our work sheds new light on the release and transport of INMs from birch surfaces into the troposphere. Birches growing in boreal and alpine forests should be considered an important terrestrial source of INMs.
12
Panpallı Ateş, Mehlika. "Hemiballismus After Ischemic Stroke: A Case Report." Journal of Parkinson’s Disease and Movement Disorders 17, no. 1-2 (January 12, 2015): 10–12. http://dx.doi.org/10.5606/phhb.dergisi.2014.03.
Full text
13
Müllensiefen, Daniel, Joshua Fry, Rhiannon Jones, Sagar Jilka, Lauren Stewart, and Victoria J. Williamson. "Individual Differences Predict Patterns in Spontaneous Involuntary Musical Imagery." Music Perception 31, no. 4 (December 2012): 323–38. http://dx.doi.org/10.1525/mp.2014.31.4.323.
Full textAbstract:
Involuntary musical imagery (INMI) describes the everyday phenomenon of having a tune stuck in the head. Research has established the ubiquity of this form of spontaneous cognition but the predictive role of individual differences is still debated. This study examines the impact of everyday musical behaviors and subclinical obsessive compulsive attributes on INMI experiences. In total 1,536 participants completed three online questionnaires; a novel inventory of musical behavior and INMI, and a standardized obsessive compulsion (OC) inventory. Exploratory factor analysis (N = 512) and structural equation modelling (N = 1,024) were applied. Everyday singing and music listening positively predict length and frequency of reported INMI episodes, respectively. No relationships were found with musical training. High OC was positively related to INMI frequency and disturbance, but only indirectly to INMI episode length and unpleasantness. The identified contributory factors of INMI experiences are discussed in the context of musical memory and spontaneous mental activity.
14
Lukáš, Milan. "Biosimilars monoclonal antibodies in the therapy of inflammatory bowel diseases An important milestone in the development of Crohn’s disease and ulcerative colitis therapy, or just a sophisticated generic?" Gastroenterologie a hepatologie 75, no. 6 (December 31, 2021): 550–55. http://dx.doi.org/10.48095/ccgh2021550.
Full textAbstract:
Summary: In 2013, EMA approved the fi rst biosimilar infl iximab CT-P13 for clinical practice in all indications of the original infl iximab. Since 2015, biosimilar infl iximab has been extensively used in patients with Crohn‘s disease and ulcerative colitis also in the Czech Republic. Biosimilar infl iximab is very similar to the original infl iximab in terms of its macromolecular structure, and its clinical eff ects, adverse events and immunogenicity are identical to those of the original infl iximab. Biosimilar biologics which have been introduced in clinical practice signifi cantly reduced therapeutic costs and improved access to an innovative therapy and facilitated a new therapeutic strategy, with pro-active drug monitoring and fl exibility in dosing. Biosimilars are associated with a signifi cant improvement in the therapeutic armamentarium, which makes them one of the important therapeutic milestones in the treatment of infl ammatory bowel disease. Key words: bio similars – bio logic therapy – Crohn’s disease – ulcerative colitis
15
Maltsev, Victor A., John W. Kyle, Sudhish Mishra, and Abertas Undrovinas. "Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition." American Journal of Physiology-Heart and Circulatory Physiology 295, no. 2 (August 2008): H667—H676. http://dx.doi.org/10.1152/ajpheart.00111.2008.
Full textAbstract:
Late Na+ current ( INaL) is a major component of the action potential plateau in human and canine myocardium. Since INaL is increased in heart failure and ischemia, it represents a novel potential target for cardioprotection. However, the molecular identity of INaL remains unclear. We tested the hypothesis that the cardiac Na+ channel isoform (Nav1.5) is a major contributor to INaL in adult dog ventricular cardiomyocytes (VCs). Cultured VCs were exposed to an antisense morpholino-based oligonucleotide (Nav1.5 asOligo) targeting the region around the start codon of Nav1.5 mRNA or a control nonsense oligonucleotide (nsOligo). Densities of both transient Na+ current ( INaT) and INaL (both in pA/pF) were monitored by whole cell patch clamp. In HEK293 cells expressing Nav1.5 or Nav1.2, Nav1.5 asOligo specifically silenced functional expression of Nav1.5 (up to 60% of the initial INaT) but not Nav1.2. In both nsOligo-treated controls and untreated VCs, INaT and INaL remained unchanged for up to 5 days. However, both INaT and INaL decreased exponentially with similar time courses (τ = 46 and 56 h, respectively) after VCs were treated with Nav1.5 asOligo without changes in 1) decay kinetics, 2) steady-state activation and inactivation, and 3) the ratio of INaL to INaT. Four days after exposure to Nav1.5 asOligo, INaT and INaL amounted to 68 ± 6% (mean ± SE; n = 20, P < 0.01) and 60 ± 7% ( n = 11, P < 0.018) of those in VCs treated by nsOligo, respectively. We conclude that in adult dog heart Nav1.5 sodium channels have a “functional half-life” of ∼35 h (0.69τ) and make a major contribution to INaL.
16
Zeng, Bin, Xiaoting Liao, Lei Liu, Huaiyu Ruan, and Caixia Zhang. "Thyroid Hormone Diminishes Ca2+ Overload Induced by Hypoxia/Reoxygenation in Cardiomyocytes by Inhibiting Late Sodium Current and Reverse-Na+/Ca2+ Exchange Current." Pharmacology 105, no. 1-2 (September 12, 2019): 63–72. http://dx.doi.org/10.1159/000502804.
Full textAbstract:
Background and Purpose: Intracellular calcium concentration ([Ca2+]i) overload occurs in myocardial ischemia and reperfusion. The augmentation of the late sodium current (INaL) causes intracellular Na+ accumulation and subsequent [Ca2+]i overload via the reverse mode of the Na+/Ca2+ exchange current (reverse-INCX), which can lead to arrhythmia and cardiac dysfunction. Thus, inhibition of INaL is a potential therapeutic approach for ischemic heart disease. The aim of this study was to investigate the effects of thyroid hormone on augmented INaL, reverse-INCX, altered action potential duration (APD), and [Ca2+]i concentration in hypoxia/reoxygenation (H/R)-induced ventricular myocytes in vitro. Methods: The transient Na+ current (INaT), INaL, reverse-INCX, and APs were recorded using a whole-cell patch-clamp technique in neonatal mouse ventricular myocytes. [Ca2+]i concentration alteration were, respectively, observed by confocal microscopy and flow cytometry. Results: Triiodothyronine (T3) pretreatment decreased the INaL in a concentration-dependent manner. H/R injury aggravated the INaL, INaT, and reverse-INCX in cardiomyocytes and increased the continuous accumulation of [Ca2+]i (p < 0.05). The application of T3 prior to H/R injury significantly decreased the increased INaL, INaT, and reverse-INCX and blunted the [Ca2+]i increase. Furthermore, T3 pretreatment shortened the APD induced by H/R injury. Conclusion: T3 inhibited H/R-increased INaL and reverse INCX augmentation, shortened the APD, and diminished [Ca2+]i overload, indicating a potential therapeutic use of T3 as an INaL inhibitor to maintain Ca2+ homeostasis and protect cardiomyocytes against H/R injury.
17
Liikkanen, Lassi A., and Kelly Jakubowski. "Involuntary musical imagery as a component of ordinary music cognition: A review of empirical evidence." Psychonomic Bulletin & Review 27, no. 6 (June 24, 2020): 1195–217. http://dx.doi.org/10.3758/s13423-020-01750-7.
Full textAbstract:
AbstractInvoluntary musical imagery (INMI) refers to a conscious mental experience of music that occurs without deliberate efforts to initiate or sustain it. This experience often consists of the repetition of a short fragment of a melody, colloquially called an “earworm.” Here, we present the first comprehensive, qualitative review of published empirical research on INMI to date. We performed an extensive literature search and discovered, in total, 47 studies from 33 peer-reviewed articles that met the inclusion criteria for the review. In analyzing the content of these studies, we identified four major research themes, which concern the phenomenology, dynamics, individual differences, and musical features of INMI. The findings answer many questions of scientific interest—for instance, what is typical in terms of INMI frequency, duration, and content; which factors influence INMI onset; and whether demographic and personality factors can explain individual differences in susceptibility and responses to INMI. This review showcases INMI as a well-established phenomenon in light of a substantial body of empirical studies that have accumulated consistent results. Although the populations under study show an unfavorable bias towards Western, educated participants, the evidence depicts INMI as a universal psychological phenomenon, the possible function of which we do not yet fully understand. The concluding section introduces several suggestions for future research to expand on the topic.
18
Krem, Maxwell M., and Ajay K. Gopal. "New Targeted Therapies for Indolent B-Cell Malignancies in Older Patients." American Society of Clinical Oncology Educational Book, no. 35 (May 2015): e365-e374. http://dx.doi.org/10.14694/edbook_am.2015.35.e365.
Full textAbstract:
Molecularly targeted agents have become an established component of the treatment of indolent B-cell malignancies (iNHL). iNHL disproportionately affects older adults, so treatments that have excellent tolerability and efficacy across multiple lines of therapy are in demand. The numbers and classes of targeted therapies for iNHL have proliferated rapidly in recent years; classes of agents that show promise for older patients with iNHL include anti-CD20 antibodies, phosphatidyl-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway inhibitors, immunomodulators, proteasome inhibitors, epigenetic modulators, and immunotherapies. Here, we review the proposed mechanisms of action, efficacy, and tolerability of novel agents for iNHL, with an emphasis on their applicability to older patients.
19
Zhang, Li Jing, Feng Ying Bai, Xue Gao, Ning Du, Yong Heng Xing, and Li Xian Sun. "Multifunctional indium complexes with fluorescent sensing and selective adsorption dye properties." New Journal of Chemistry 41, no. 14 (2017): 6883–92. http://dx.doi.org/10.1039/c7nj00680b.
Full textAbstract:
Four new complexes [InCl2(Hphth)(4,4′-bipy)0.5(H2O)]·2H2O (H2phth = phthalic acid, 4,4′-bipy = 4,4′-bipyridine) (1), [InCl4(4,4′-bipyH)(H2O)] (2), [InCl(Hphth)(nia)(H2O)2] (Hnia = nicotinic acid) (3), [InCl(Hnia)2(Hox)2]·3H2O (H2ox = oxalic acid) (4) were synthesized by the reaction of Indium chloride (InCl3) with H2phth, Hnia, 4,4′-bipy and H2ox as the ligands.
20
Lupica, Antonino, Vincenzo Di Stefano, Andrea Gagliardo, Salvatore Iacono, Antonia Pignolo, Salvatore Ferlisi, Angelo Torrente, Sonia Pagano, Massimo Gangitano, and Filippo Brighina. "Inherited Neuromuscular Disorders: Which Role for Serum Biomarkers?" Brain Sciences 11, no. 3 (March 21, 2021): 398. http://dx.doi.org/10.3390/brainsci11030398.
Full textAbstract:
Inherited neuromuscular disorders (INMD) are a heterogeneous group of rare diseases that involve muscles, motor neurons, peripheral nerves or the neuromuscular junction. Several different lab abnormalities have been linked to INMD: sometimes they are typical of the disorder, but they usually appear to be less specific. Sometimes serum biomarkers can point out abnormalities in presymtomatic or otherwise asymptomatic patients (e.g., carriers). More often a biomarker of INMD is evaluated by multiple clinicians other than expert in NMD before the diagnosis, because of the multisystemic involvement in INMD. The authors performed a literature search on biomarkers in inherited neuromuscular disorders to provide a practical approach to the diagnosis and the correct management of INMD. A considerable number of biomarkers have been reported that support the diagnosis of INMD, but the role of an expert clinician is crucial. Hence, the complete knowledge of such abnormalities can accelerate the diagnostic workup supporting the referral to specialists in neuromuscular disorders.
21
Seifried, Teresa M., Florian Reyzek, Paul Bieber, and Hinrich Grothe. "Scots Pines (Pinus sylvestris) as Sources of Biological Ice-Nucleating Macromolecules (INMs)." Atmosphere 14, no. 2 (January 28, 2023): 266. http://dx.doi.org/10.3390/atmos14020266.
Full textAbstract:
Scots pine (Pinus sylvestris) is the most widespread pine species in the world. It grows in the largest forest system in the northern hemisphere and, together with birch trees, occupies a major part of the boreal forests. Recently, birch trees have been discovered as important emission sources of terrestrial ice-nucleating macromolecules (INMs) coming from pollen, bark, leaves, petioles, branches, and stem surfaces. It is known that pine pollen nucleate ice; however, the potential of other tree parts releasing INMs and contributing to the emission of ice-active aerosols is unknown. Here, we investigated the distribution of INMs in, on, and around Scots pines (Pinus sylvestris) in a laboratory and field study. We collected bark, branch wood, and needle samples from six pine trees in an urban park in Vienna, Austria. The concentration of INMs from aqueous extracts of milled (powder extracts) and intact surfaces (surface extracts) were determined. In addition, we collected rainwater rinsed off from three pines during a rainfall event and analyzed its INM content. All investigated samples contained INMs with freezing onset temperatures ranging from −16 °C to −29 °C. The number concentration of INMs in powder extracts at −25 °C ( ranged from 105 to 109 per mg dry weight. Surface extracts showed concentrations from 105 to 108 INMs per cm2 of extracted surface, with needle samples exhibiting the lowest concentrations. In the rain samples, we found 106 and 107 INMs per cm2 of rain-collector area at −25 °C, with freezing onset temperatures similar to those observed in powder and surface extracts. With our data, we estimate that one square meter of pine stand can release about 4.1 × 109 to 4.6 × 1012 INMs active at −25 °C and higher, revealing pine forests as an extensive reservoir of INMs. Since pines are evergreen and release INMs not only from pollen grains, pines and the boreal forest in general need to be considered as a dominant source of INMs in high latitude and high-altitude locations, where other species are rare and other ice nuclei transported over long distances are diluted. Finally, we propose pine trees as an INM emission source which can trigger immersion freezing events in cloud droplets at moderate supercooled temperatures and therefore may have a significant impact on altering mixed phase clouds.
22
Huang, Guiting, Shuyuan Shuai, Weicheng Zhou, Yingchong Chen, Baode Shen, and Pengfei Yue. "To Enhance Mucus Penetration and Lung Absorption of Drug by Inhalable Nanocrystals-In-Microparticles." Pharmaceutics 14, no. 3 (February 28, 2022): 538. http://dx.doi.org/10.3390/pharmaceutics14030538.
Full textAbstract:
To effectively achieve the pulmonary delivery for curcumin (CN), novel inhalable mucus-penetrating nanocrystal-based microparticles (INMP) were designed. The D-Tocopherol acid polyethylene glycol 1000 succinate (TPGS) modified CN nanocrystals (CN-NS@TPGS) were prepared by high pressure homogenization and further converted into nanocrystal-based microparticles (CN-INMP@TPGS) using spray-drying. It was demonstrated that CN-NS@TPGS exhibited little interaction with the negatively charged mucin due to a strong electrostatic repulsion effect and PEG hydrophilic chain, and exhibited a much higher penetration ability across the mucus layer compared with poloxamer 407 modified CN-NS (CN-NS@P407) and tween 80 modified CN-NS (CN-NS@TW80). The aerodynamic results demonstrated that the CN-INMP with 10% TPGS acting as the stabilizer presented a high FPF value, indicating excellent deposition in the lung after inhalation administration. Additionally, in vivo bioavailability studies indicated that the AUC(0-t) of CN-INMP@TPGS (2413.18 ± 432.41 µg/L h) were 1.497- and 3.32-fold larger compared with those of CN-INMP@TW80 (1612.35 ± 261.35 µg/L h) and CN-INMP@P407 (3.103 ± 196.81 µg/L h), respectively. These results indicated that the CN-INMP@TPGS were absorbed rapidly after pulmonary administration and resulted in increased systemic absorption. Therefore, the inhalable CN-INMP could significantly improve the bioavailability of CN after inhalation administration. The developed mucus-penetrating nanocrystals-in-microparticles might be regarded as a promising formulation strategy for the pulmonary administration of poorly soluble drugs.
23
Shyng, Charles, and Mark S. Sands. "Astrocytosis in infantile neuronal ceroid lipofuscinosis: friend or foe?" Biochemical Society Transactions 42, no. 5 (September 18, 2014): 1282–85. http://dx.doi.org/10.1042/bst20140188.
Full textAbstract:
Infantile neuronal ceroid lipofuscinosis (INCL; infantile Batten disease) is an inherited paediatric neurodegenerative disease. INCL is caused by a deficiency in the lysosomal enzyme palmitoyl-protein thioesterase-1 (PPT1) and is thus classified as a lysosomal storage disease. Pathological examination of both human and murine INCL brains reveals progressive, widespread neuroinflammation. In fact, astrocyte activation appears to be the first histological sign of disease. However, the role of astrocytosis in INCL was poorly understood. The hallmark of astrocyte activation is the up-regulation of intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin. The role of astrocytosis in INCL was studied in a murine model lacking PPT1 and the intermediate filaments GFAP and vimentin (triple-knockout). This murine model of INCL with attenuated astrocytosis had an exacerbated pathological and clinical phenotype. The triple-knockout mouse had a significantly shortened lifespan, and accelerated cellular and humoural neuroinflammatory response compared with the parental PPT1−/− mouse. The data obtained from the triple-knockout mouse strongly suggest that astrocyte activation plays a beneficial role in early INCL disease progression. A more thorough understanding of the glial responses to lysosomal enzyme deficiencies and the accumulation of undergraded substrates will be crucial to developing effective therapeutics.
24
Maltsev, Victor A., Vitaliy Reznikov, Nidas A. Undrovinas, Hani N. Sabbah, and Albertas Undrovinas. "Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 4 (April 2008): H1597—H1608. http://dx.doi.org/10.1152/ajpheart.00484.2007.
Full textAbstract:
Augmented and slowed late Na+ current ( INaL) is implicated in action potential duration variability, early afterdepolarizations, and abnormal Ca2+ handling in human and canine failing myocardium. Our objective was to study INaL modulation by cytosolic Ca2+ concentration ([Ca2+]i) in normal and failing ventricular myocytes. Chronic heart failure was produced in 10 dogs by multiple sequential coronary artery microembolizations; 6 normal dogs served as a control. INaL fine structure was measured by whole cell patch clamp in ventricular myocytes and approximated by a sum of fast and slow exponentials produced by burst and late scattered modes of Na+ channel gating, respectively. INaL greatly enhanced as [Ca2+]i increased from “Ca2+ free” to 1 μM: its maximum density increased, decay of both exponentials slowed, and the steady-state inactivation (SSI) curve shifted toward more positive potentials. Testing the inhibition of CaMKII and CaM revealed similarities and differences of INaL modulation in failing vs. normal myocytes. Similarities include the following: 1) CaMKII slows INaL decay and decreases the amplitude of fast exponentials, and 2) Ca2+ shifts SSI rightward. Differences include the following: 1) slowing of INaL by CaMKII is greater, 2) CaM shifts SSI leftward, and 3) Ca2+ increases the amplitude of slow exponentials. We conclude that Ca2+/CaM/CaMKII signaling increases INaL and Na+ influx in both normal and failing myocytes by slowing inactivation kinetics and shifting SSI. This Na+ influx provides a novel Ca2+ positive feedback mechanism (via Na+/Ca2+ exchanger), enhancing contractions at higher beating rates but worsening cardiomyocyte contractile and electrical performance in conditions of poor Ca2+ handling in heart failure.
25
Copeland, Natalia E. "InMI and its potential originality – musical creativity in composers’ minds." Interdisciplinary Studies in Musicology, no. 19 (December 31, 2019): 41–52. http://dx.doi.org/10.14746/ism.2019.19.3.
Full textAbstract:
The current article explores the potential innovativeness of Involuntary Musical Imagery and presents the current state of InMI researches. There is a lack of precise definition of the term, as well as related terms (such as earworm or musical imagery). InMI is often equated to earworms which does not do justice to its creative potential. Several authors suggest that InMI can be a source of new melodies useful for composers in their composition process. The article proposes that InMI can consist of new melodies and appear as a single event. Composers use their working memory and musical abilities to volitionaly loop the tune in their head, then transcribe it into external realm (notation, recording). Composers can later use it in their creative process. The use of InMI in composing is a matter of individual differences between composers.
26
Woliński, Marcin, and Witold Kieraś. "ANALIZA FLEKSYJNA TEKSTÓW HISTORYCZNYCH I ZMIENNOŚĆ FLEKSJI POLSKIEJ Z PERSPEKTYWY DANYCH KORPUSOWYCH." Poradnik Językowy, no. 8/2020(777) (October 28, 2020): 66–80. http://dx.doi.org/10.33896/porj.2020.8.5.
Full textAbstract:
The subject matter of this paper is Chronofl eks, a computer system (http:// chronofl eks.nlp.ipipan.waw.pl/) modelling Polish infl ection based on a corpus material. The system visualises changes of infl ectional paradigms of individual lexemes over time and enables examination of the variability of the frequency of infl ected form groups distinguished based on various criteria. Feeding Chronofl eks with corpus data required development of IT tools to ensure an infl ectional processing sequence of texts analogous to the ones used for modern language; they comprise a transcriber, a morphological analyser, and a tagger. The work was performed on data from three historical periods (1601–1772, 1830–1918, and modern ones) elaborated in independent projects. Therefore, fi nding a common manner of describing data from the individual periods was a signifi cant element of the work. Keywords: electronic text corpus – natural language processing – infl ection of Polish – history of language
27
Hasanah, Eneng Nur. "INFLATION, INTEREST RATE AND CREDIT RATE IN INDONESIA." Jurnal Manajemen Indonesia 17, no. 2 (November 17, 2017): 15. http://dx.doi.org/10.25124/jmi.v17i2.1064.
Full textAbstract:
Infl asi akan mempengaruhi tingkat suku bunga. Ketika infl asi naik maka tingkat suku bungaakan meningkat begitupun sebaliknya, ketika infl asi turun maka tingkat suku bunga akanmenurun juga. Tidak seperti negara lain, Indonesia memiliki keadaan yang unik, terkadangmeskipun BI Rate turun namun tingkat kredit tidak turun. Jadi, berdasarkan kasus ini, makalahini mengkaji hubungan Infl asi, Suku Bunga dan Tingkat Kredit. Dengan menggunakanmodel Vasicek, paper ini mengevaluasi fi tting long-term, speed and volatility dari setiaptingkat kredit berdasarkan kategori bank di Indonesia. Kemudian menilai tingkat fl uktuasipada masing-masing bank. Tingkat masing-masing kategori bank sangat fl uktuasi namuntidak lebih dari 0,005 dan tidak lebih rendah dari 0,005.
28
Belov, V. B. "German Foreign Policy in the Face of Current Challenges." Journal of International Analytics 12, no. 3 (October 20, 2021): 38–58. http://dx.doi.org/10.46272/2587-8476-2021-12-3-38-58.
Full textAbstract:
The article analyzes the features of German foreign policy on the eve of the September (2021) elections to the Bundestag and the gradual overcoming of the crisis consequences of the coronavirus pandemic. The priorities of the foreign policy based on the value approach remain the European and transatlantic vectors, as well as relations with the main system-forming international organizations. The postulates of value are prompting Berlin to increasingly intensify criticism of Russia and China, incl. due to the signifi cantly increased, from his point of view, threats in relation to Germany and other states of the collective West. Germany still relies on France in European politics. Their tandem continues to determine the political and economic processes in the European Union, as well as to infl uence the formation of the EU mechanisms for overcoming the coronavirus crisis. Despite the rapid restoration of constructive relations with the new American administration, a number of controversial issues remain in bilateral relations, including defense spending and the economy. In recent years, Germany has been able to strengthen its positions in Europe and the world and expects to strengthen its role as a global actor, especially in international organizations. Nevertheless, the German expert community critically refers to its current foreign policy status quo. The author explores the latest trends in German foreign policy, gives an assessment of its development after elections to the Bundestag, pays special attention to the prospects for relations with the Russian Federation.
29
Kiss, Dénes, Balázs Horváth, Tamás Hézső, Csaba Dienes, Zsigmond Kovács, Leila Topal, Norbert Szentandrássy, et al. "Late Na+ Current Is [Ca2+]i-Dependent in Canine Ventricular Myocytes." Pharmaceuticals 14, no. 11 (November 11, 2021): 1142. http://dx.doi.org/10.3390/ph14111142.
Full textAbstract:
Enhancement of the late sodium current (INaL) increases arrhythmia propensity in the heart, whereas suppression of the current is antiarrhythmic. In the present study, we investigated INaL in canine ventricular cardiomyocytes under action potential voltage-clamp conditions using the selective Na+ channel inhibitors GS967 and tetrodotoxin. Both 1 µM GS967 and 10 µM tetrodotoxin dissected largely similar inward currents. The amplitude and integral of the GS967-sensitive current was significantly smaller after the reduction of intracellular Ca2+ concentration ([Ca2+]i) either by superfusion of the cells with 1 µM nisoldipine or by intracellular application of 10 mM BAPTA. Inhibiting calcium/calmodulin-dependent protein kinase II (CaMKII) by KN-93 or the autocamtide-2-related inhibitor peptide similarly reduced the amplitude and integral of INaL. Action potential duration was shortened in a reverse rate-dependent manner and the plateau potential was depressed by GS967. This GS967-induced depression of plateau was reduced by pretreatment of the cells with BAPTA-AM. We conclude that (1) INaL depends on the magnitude of [Ca2+]i in canine ventricular cells, (2) this [Ca2+]i-dependence of INaL is mediated by the Ca2+-dependent activation of CaMKII, and (3) INaL is augmented by the baseline CaMKII activity.
30
Pummer, B. G., C. Budke, S. Augustin-Bauditz, D. Niedermeier, L. Felgitsch, C. J. Kampf, R. G. Huber, et al. "Ice nucleation by water-soluble macromolecules." Atmospheric Chemistry and Physics 15, no. 8 (April 21, 2015): 4077–91. http://dx.doi.org/10.5194/acp-15-4077-2015.
Full textAbstract:
Abstract. Cloud glaciation is critically important for the global radiation budget (albedo) and for initiation of precipitation. But the freezing of pure water droplets requires cooling to temperatures as low as 235 K. Freezing at higher temperatures requires the presence of an ice nucleator, which serves as a template for arranging water molecules in an ice-like manner. It is often assumed that these ice nucleators have to be insoluble particles. We point out that also free macromolecules which are dissolved in water can efficiently induce ice nucleation: the size of such ice nucleating macromolecules (INMs) is in the range of nanometers, corresponding to the size of the critical ice embryo. As the latter is temperature-dependent, we see a correlation between the size of INMs and the ice nucleation temperature as predicted by classical nucleation theory. Different types of INMs have been found in a wide range of biological species and comprise a variety of chemical structures including proteins, saccharides, and lipids. Our investigation of the fungal species Acremonium implicatum, Isaria farinosa, and Mortierella alpina shows that their ice nucleation activity is caused by proteinaceous water-soluble INMs. We combine these new results and literature data on INMs from fungi, bacteria, and pollen with theoretical calculations to develop a chemical interpretation of ice nucleation and water-soluble INMs. This has atmospheric implications since many of these INMs can be released by fragmentation of the carrier cell and subsequently may be distributed independently. Up to now, this process has not been accounted for in atmospheric models.
31
AYDOĞAN ARSLAN, Saniye, Cevher DEMİRCİ, Zekiye İpek KATIRCI KIRMACI, Kübra UĞURLU, and Esra Dilek KESKİN. "Examination of the Scales and Tests Evaluating the Risk of Falling in Stroke Patients." Turkiye Klinikleri Journal of Health Sciences 6, no. 3 (2021): 508–14. http://dx.doi.org/10.5336/healthsci.2020-78464.
Full text
32
KALAV, Simge, Arife ALTIN ÇETİN, and Hicran BEKTAŞ. "The Effect of Oral Hygiene Practices in Patients with Stroke: Systematic Review." Turkiye Klinikleri Journal of Nursing Sciences 12, no. 3 (2020): 430–42. http://dx.doi.org/10.5336/nurses.2020-74729.
Full text
33
Risti, Khairunnisa Nadya, Eti Poncorini Pamungkasari, and Suminah Suminah. "RELATIONSHIP OF PEER INFLUENCE AND FAMILY EATING HABITS ON HEALTHY FOOD CHOICES IN OVERWEIGHT ADOLESCENTS IN SURAKARTA." Media Gizi Indonesia 16, no. 2 (May 28, 2021): 124. http://dx.doi.org/10.20473/mgi.v16i2.124-129.
Full textAbstract:
Unhealthy eating habits among Indonesian occur not only in adults, but also in adolescents. Adolescence is a transitional period and most easily aff ected by the surrounding environment. Environmental infl uences such as peer infl uence and family eating habits are dominant factors for food they choose to consume. This study aimed at analyzing the relationship of peer infl uence and family eating habits on healthy food choices in overweight adolescents in Surakarta. It used observational study with cross sectional approach. Random sampling was used to determine its samples, consisting of 96 respondents. The data of peer infl uence, family eating habits, and healthy food choices were collected through structured questionnaires. They were analyzed by using the Pearson Product Moment statistical test. The results indicated that there is a relationship between peer infl uence and healthy food choices in overweight adolescents in Surakarta (p = 0.014; r = -0.250); and there is a signifi cant relationship between family eating habits and healthy food choices in overweight adolescents in Surakarta (p = 0.011; r = 0.258).
34
Mishra, Sudhish, Nidas A. Undrovinas, Victor A. Maltsev, Vitaliy Reznikov, Hani N. Sabbah, and Albertas Undrovinas. "Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 4 (October 2011): H1596—H1605. http://dx.doi.org/10.1152/ajpheart.00948.2009.
Full textAbstract:
The emerging paradigm for Na+ current in heart failure (HF) is that its transient component ( INaT) responsible for the action potential (AP) upstroke is decreased, whereas the late component ( INaL) involved in AP plateau is augmented. Here we tested whether Navβ1- and Navβ2-subunits can modulate INaL parameters in normal and failing ventricular cardiomyocytes (VCMs). Chronic HF was produced in nine dogs by multiple sequential coronary artery microembolizations, and six dogs served as a control. INa and APs were measured by the whole cell and perforated patch-clamp in freshly isolated and cultured VCMs, respectively. INaL was augmented with slower decay in HF VCMs compared with normal heart VCMs, and these properties remained unchanged within 5 days of culture. Post-transcriptional silencing SCN1B and SCN2B were achieved by virally delivered short interfering RNA (siRNA) specific to Navβ1 and Navβ2. The delivery and efficiency of siRNA were evaluated by green fluorescent protein expression, by the real-time RT-PCR, and Western blots, respectively. Five days after infection, the levels of mRNA and protein for Navβ1 and Navβ2 were reduced by >80%, but mRNA and protein of Nav1.5, as well as INaT, remained unchanged in HF VCMs. Navβ1-siRNA reduced INaL density and accelerated INaL two-exponential decay, whereas Navβ2-siRNA produced an opposite effect in VCMs from both normal and failing hearts. Physiological importance of the discovered INaL modulation to affect AP shape and duration was illustrated both experimentally and by numerical simulations of a VCM excitation-contraction coupling model. We conclude that in myocytes of normal and failing dog hearts Navβ1 and Navβ2 exhibit oppositely directed modulation of INaL.
35
Sherman, Philip M., Mary-Jo Makarchuk, Paul Belanger, and Eve A. Roberts. "Strategic Plan of the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and Diabetes." Canadian Journal of Gastroenterology 25, no. 10 (2011): 560–64. http://dx.doi.org/10.1155/2011/293034.
Full textAbstract:
The present document provides the new and updated strategic plan for the Institute of Nutrition, Metabolism, and Diabetes (INMD) of the Canadian Institutes of Health Research. This plan provides an overarching map for the strategic activities of the INMD during the five years from 2010 to 2014. These strategic priorities will guide the way that the INMD uses its resources over this period of time, and will provide opportunities to build new partnerships and strategic alliances that enhance and leverage the capacity to fund targeted research initiatives.
36
Balouch, Bailey, Halle Nagorsky, Truc Pham, James Thai LaGraff, and Quynh Chu-LaGraff. "Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death." PLOS ONE 16, no. 2 (February 9, 2021): e0239689. http://dx.doi.org/10.1371/journal.pone.0239689.
Full textAbstract:
Infantile Neuronal Ceroid Lipofuscinosis (INCL) is a pediatric neurodegenerative disorder characterized by progressive retinal and central nervous system deterioration during infancy. This lysosomal storage disorder results from a deficiency in the Palmitoyl Protein Thioesterase 1 (PPT1) enzyme—a lysosomal hydrolase which cleaves fatty acid chains such as palmitate from lipid-modified proteins. In the absence of PPT1 activity, these proteins fail to be degraded, leading to the accumulation of autofluorescence storage material in the lysosome. The underlying molecular mechanisms leading to INCL pathology remain poorly understood. A role for oxidative stress has been postulated, yet little evidence has been reported to support this possibility. Here we present a comprehensive cellular characterization of human PPT1-deficient fibroblast cells harboring Met1Ile and Tyr247His compound heterozygous mutations. We detected autofluorescence storage material and observed distinct organellar abnormalities of the lysosomal and mitochondrial structures, which supported previous postulations about the role of ER, mitochondria and oxidative stress in INCL. An increase in the number of lysosomal structures was found in INCL patient fibroblasts, which suggested an upregulation of lysosomal biogenesis, and an association with endoplasmic reticulum stress response. The mitochondrial network also displayed abnormal spherical punctate morphology instead of normal elongated tubules with extensive branching, supporting the involvement of mitochondrial and oxidative stress in INCL cell death. Autofluorescence accumulation and lysosomal pathologies can be mitigated in the presence of conditioned wild type media suggesting that a partial restoration via passive introduction of the enzyme into the cellular environment may be possible. We also demonstrated, for the first time, that human INCL fibroblasts have a heightened susceptibility to exogenous reactive oxygen species (ROS)-induced cell death, which suggested an elevated basal level of endogenous ROS in the mutant cell. Collectively, these findings support the role of intracellular organellar networks in INCL pathology, possibly due to oxidative stress.
37
Yao, Lina, Peidong Fan, Zhan Jiang, Serge Viatchenko-Karpinski, Yuzhi Wu, Dmytro Kornyeyev, Ryoko Hirakawa, et al. "Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice." American Journal of Physiology-Cell Physiology 301, no. 3 (September 2011): C577—C586. http://dx.doi.org/10.1152/ajpcell.00125.2011.
Full textAbstract:
Late Na+ current ( INaL) and Ca2+/calmodulin-dependent protein kinase II (CaMKII) are both increased in the diseased heart. Recently, CaMKII was found to phosphorylate the Na+ channel 1.5 (Nav1.5), resulting in enhanced INaL. Conversely, an increase of INaL would be expected to cause elevation of intracellular Ca2+ and activation of CaMKII. However, a relationship between enhancement of INaL and activation of CaMKII has yet to be demonstrated. We investigated whether Na+ influx via Nav1.5 leads to CaMKII activation and explored the functional significance of this pathway. In neonatal rat ventricular myocytes (NRVM), treatment with the INaL activators anemone toxin II (ATX-II) or veratridine increased CaMKII autophosphorylation and increased phosphorylation of CaMKII substrates phospholamban and ryanodine receptor 2. Knockdown of Nav1.5 (but not Nav1.1 or Nav1.2) prevented ATX-II-induced CaMKII phosphorylation, providing evidence for a specific role of Nav1.5 in CaMKII activation. In support of this view, CaMKII activity was also increased in hearts of transgenic mice overexpressing a gain-of-function Nav1.5 mutant (N1325S). The effects of both ATX-II and the N1325S mutation were reversed by either INaL inhibition (with ranolazine or tetrodotoxin) or CaMKII inhibition (with KN93 or autocamtide 2-related inhibitory peptide). Furthermore, ATX-II treatment also induced CaMKII-Nav1.5 coimmunoprecipitation. The same association between CaMKII and Nav1.5 was also found in N1325S mice, suggesting a direct protein-protein interaction. Pharmacological inhibitions of either CaMKII or INaL also prevented ATX-II-induced cell death in NRVM and reduced the incidence of polymorphic ventricular tachycardia induced by ATX-II in rat perfused hearts. Taken together, these results suggest that a Nav1.5-dependent increase in Na+ influx leads to activation of CaMKII, which in turn phosphorylates Nav1.5, further promoting Na+ influx. Pharmacological inhibition of either CaMKII or Nav1.5 can ameliorate cardiac dysfunction caused by excessive Na+ influx.
38
Zaccone, Alessio, and Matteo Baggioli. "Universal law for the vibrational density of states of liquids." Proceedings of the National Academy of Sciences 118, no. 5 (January 25, 2021): e2022303118. http://dx.doi.org/10.1073/pnas.2022303118.
Full textAbstract:
An analytical derivation of the vibrational density of states (DOS) of liquids, and, in particular, of its characteristic linear in frequency low-energy regime, has always been elusive because of the presence of an infinite set of purely imaginary modes—the instantaneous normal modes (INMs). By combining an analytic continuation of the Plemelj identity to the complex plane with the overdamped dynamics of the INMs, we derive a closed-form analytic expression for the low-frequency DOS of liquids. The obtained result explains, from first principles, the widely observed linear in frequency term of the DOS in liquids, whose slope appears to increase with the average lifetime of the INMs. The analytic results are robustly confirmed by fitting simulations data for Lennard-Jones liquids, and they also recover the Arrhenius law for the average relaxation time of the INMs, as expected.
39
Santorini, Beatrice. "The rate of phrase structure change in the history of Yiddish." Language Variation and Change 5, no. 3 (October 1993): 257–83. http://dx.doi.org/10.1017/s0954394500001502.
Full textAbstract:
ABSTRACTThe postion of inflected verbs in early Yiddish varies between second position and positions later in the clause. Standard distributional tests establish that this reflects variation in the underlying position of infl, and that Yiddish phrase structure changed from infl-final to infl-medial. Based on clauses containing the relevant structural diagnostics, we can estimate the rate of this change. We cannot, however, determine the phrase structure of structurally ambiguous clauses (i.e., those superficially consistent with either of the phrase structures) with certainty. Nevertheless, we can use quantitative methods to estimate the likelihood of such clauses being infl-medial, and we can then use these likelihoods to provide an additional estimate of the rate of the change. Comparing both estimates reveals that they do not differ significantly. The implications of this result are briefly examined in conclusion.
40
Androsova, L. V., E. S. Shipilova, A. N. Simonov, I. N. Otman, T. P. Klyushnik, and N. M. Mikhaylova. "Immunological Indicators of Infl ammation in Late-Life Bipolar Disorder." Psikhiatriya 19, no. 3 (October 14, 2021): 22–33. http://dx.doi.org/10.30629/2618-6667-2021-19-3-22-33.
Full textAbstract:
The aim of the study was to determine the immune markers of infl ammation in the blood plasma of the elderly patients with bipolar affective disorders (BD) in relation to the clinical specifi cities of the disease. Patients and methods: 134 blood samples from the elderly patients aged from 52 to 88 years old (mean age 66.7 ± 7.7 years) with diagnose of bipolar disorder were examined. Infl ammatory markers in the blood plasma were determined as follows: the enzymatic activity of leukocyte elastase (LE) and the functional activity of the D1-proteinase inhibitor (D1-PI), as well as the level of autoantibodies (aAB) to S100b and myelin basic protein (MBP), and the protease inhibitor index (PII), which was the ratio of LE and D1-PI activity and characterized the activity of the proteolytic system as the most important component of infl ammation. Cluster analysis was used to reveal immunotypes. Results and discussion: а signifi cant increase in D1-PI and the level of aAB to S100b was revealed in elderly patients diagnosed with bipolar disorders, as well as low proteolytic activity of infl ammation (according to PII). Immune markers of infl ammation in different types of affective episodes (depressions, manias, mixed affective states) and in therapeutic remission did not differ from each other. Immunological parameters in elderly patients with bipolar disorders depended on the severity degree of the affective disorder. A relationship was found between the severity of depression and the level of aAB to S100b; the difference between mania and hypomania in terms of LE and PII activity was shown; in mixed affective states immunological parameters differed from the control only in moderate disorders. Remission with residual symptoms differed from asymptomatic therapeutic remission in terms of LE and PII activity. The two identifi ed clusters (immunotypes) differed in the activity of LE and PII. Conclusion: the results indicated the participation of infl ammation in the pathogenesis of bipolar disorder, and the isolated immunotypes confi rmed the clinical diversity of the disease. The study of the pathogenetic signifi cance of infl ammation and the identifi cation of various immunotypes was aimed at search for new therapy targets, taking into account the contribution of infl ammation.
41
Ibañez, Elina Mendoza. "Epidemiologia de las infecciones virales en la unidad de cuidados intensivos neonatales. Instituto Nacional Materno Perinatal 2013 – 2014." Revista Peruana de Investigación Materno Perinatal 5, no. 1 (January 3, 2016): 23–27. http://dx.doi.org/10.33421/inmp.201651.
Full textAbstract:
Objetivo. Conocer la epidemiologia de las infecciones virales en UCIN-INMP. Materiales y métodos. Revisión de 50 historias clínicas de pacientes con infección viral confirmada, en los años 2013 y 2014, de UCIN — INMP y análisis estadístico descriptivo, utilizando SPSS 23.
42
Shyng, Charles, Hemanth R. Nelvagal, Joshua T. Dearborn, Jaana Tyynelä, Robert E. Schmidt, Mark S. Sands, and Jonathan D. Cooper. "Synergistic effects of treating the spinal cord and brain in CLN1 disease." Proceedings of the National Academy of Sciences 114, no. 29 (July 3, 2017): E5920—E5929. http://dx.doi.org/10.1073/pnas.1701832114.
Full textAbstract:
Infantile neuronal ceroid lipofuscinosis (INCL, or CLN1 disease) is an inherited neurodegenerative storage disorder caused by a deficiency of the lysosomal enzyme palmitoyl protein thioesterase 1 (PPT1). It was widely believed that the pathology associated with INCL was limited to the brain, but we have now found unexpectedly profound pathology in the human INCL spinal cord. Similar pathological changes also occur at every level of the spinal cord of PPT1-deficient (Ppt1−/−) mice before the onset of neuropathology in the brain. Various forebrain-directed gene therapy approaches have only had limited success in Ppt1−/− mice. Targeting the spinal cord via intrathecal administration of an adeno-associated virus (AAV) gene transfer vector significantly prevented pathology and produced significant improvements in life span and motor function in Ppt1−/− mice. Surprisingly, forebrain-directed gene therapy resulted in essentially no PPT1 activity in the spinal cord, and vice versa. This leads to a reciprocal pattern of histological correction in the respective tissues when comparing intracranial with intrathecal injections. However, the characteristic pathological features of INCL were almost completely absent in both the brain and spinal cord when intracranial and intrathecal injections of the same AAV vector were combined. Targeting both the brain and spinal cord also produced dramatic and synergistic improvements in motor function with an unprecedented increase in life span. These data show that spinal cord pathology significantly contributes to the clinical progression of INCL and can be effectively targeted therapeutically. This has important implications for the delivery of therapies in INCL, and potentially in other similar disorders.
43
Kutscher, Andrew, and Ellen Covey. "Functional Role of GABAergic and Glycinergic Inhibition in the Intermediate Nucleus of the Lateral Lemniscus of the Big Brown Bat." Journal of Neurophysiology 101, no. 6 (June 2009): 3135–46. http://dx.doi.org/10.1152/jn.00766.2007.
Full textAbstract:
The intermediate nucleus of the lateral lemniscus (INLL) is a major input to the inferior colliculus (IC), the auditory midbrain center where multiple pathways converge to create neurons selective for specific temporal features of sound. However, little is known about how INLL processes auditory information or how it contributes to integrative processes at the IC. INLL receives excitatory projections from the cochlear nucleus and inhibitory projections from the medial nucleus of the trapezoid body (MNTB), so it must perform some form of integration. To address the question of what role inhibitory synaptic inputs play in the INLL of the big brown bat ( Eptesicus fuscus), we recorded sound-evoked responses of single neurons and iontophoretically applied bicuculline to block GABAA receptors or strychnine to block glycine receptors. Neither bicuculline nor strychnine had a consistent effect on response latency or frequency response areas. Bicuculline increased spike counts and response durations in most units, suggesting that GABAergic input suppressed the late part of the response and provided some gain control. Strychnine reduced the responses of some units with sustained discharge patterns to one or a few spikes at stimulus onset, but increased others. INLL is the only part of the auditory system where reduced responsiveness has been seen in vivo while blocking glycine. However, in vitro studies in the MNTB suggest that glycine can be facilitatory, possibly through presynaptic action. These results show that GABA consistently reduces spike counts and response durations, whereas glycine is suppressive in some INLL neurons but facilitatory in others.
44
Battistella, Edwin, and Anne Lobeck. "On Verb Fronting, Inflection Movement, and Aux Support." Canadian Journal of Linguistics/Revue canadienne de linguistique 36, no. 3 (September 1991): 255–67. http://dx.doi.org/10.1017/s0008413100021551.
Full textAbstract:
Recent analyses of word order and clause structure suggest that natural language syntax employs competing processes of Verb Fronting (VF) and Inflection Movement (IM) for the realization of Tense and Agreement (TNS and AGR) features on verb stems. As the names suggest, Verb Fronting is a process that raises a verb from the head of VP to INFL and INFL Movement is a rule that lowers the contents of INFL to the head of VP. Both rules are assumed to involve Chomsky-adjunction of the moved node to the target node and both are assumed to leave a trace.
45
BALCIOĞLU, Yasin Hasan, Mine Elif TÜRE, and Nezih ERADAMLAR. "Late Onset Manic Episode Following a Stroke Related Essential Thrombocytosis: Case Report." Turkiye Klinikleri Journal of Neurology 11, no. 3 (2016): 76–80. http://dx.doi.org/10.5336/neuro.2016-50791.
Full text
46
Рожнов, Артемий, and Artemiy Rozhnov. "THE INFLUENCE OF THE BYZANTINE LAW ON THE CRIMINAL LAW OF MUSCOVY." Encyclopedia of Law 1, no. 1 (September 1, 2013): 46–50. http://dx.doi.org/10.12737/898.
Full textAbstract:
The article represents the analysis of the byzantine law’s infl uence on the criminal law of Muscovy in 14–17th centuries. The author indicates the causes and forms of this infl uence and mentions the main byzantine laws that were applied in the Muscovy.
47
Jeon, Munhee, Jongsung Oh, Kyu Yun Jang, and Ki-Yeob Jeon. "A Pilot Study: Metal-Induced Immunotoxicity and Deaths of the 100 Vaccinees in the Republic of Korea for 2 Months of 2020 Flu Vaccination." American Journal of Epidemiology & Public Health 5, no. 1 (February 2021): 014–21. http://dx.doi.org/10.37871/ajeph.id43.
Full textAbstract:
Summary: More than 100 persons died within 7 days of infl uenza vaccination by November 2020 (for two months of 2020 fl u vaccination) in the Republic of Korea (South Korea). The current study was conducted to allocate properly any possible causality by examining the presence of heavy metals in a vaccine and metal-induced immunotoxic lesions after fl u vaccinations in the experimental mice. It detected cadmium 0.12 ppb (parts per billion = μg/L) and mercury 1.77 ppb in one of the cost-free infl uenza vaccinees (Lot Number: A14720017) distributed by the Korean government. Lungs of the undiluted-vaccine-injected mice showed signifi cantly more diff use infl ammatory damages than lungs of the 1:4 dilutedvaccine-injected mice which showed no to mild infl ammatory changes (p < 0.027 by the method 1, and p < 0.001 by the method 2). Based on this study, it can be presumed that the metals-induced immunotoxicity of type IV hypersensitivity or of psuedoallergy would have caused death in some of persons who coincidentally died within 7 days of vaccinations. Background : A 17-year-old man died within three days of infl uenza vaccination (Lot Number: A14720007), a 77-year-old woman died within a day (Lot Number: A14720016), and more than 100 persons died within 7 days of infl uenza vaccination by November 2020 (for two months of 2020 fl u vaccination) in the Republic of Korea (South Korea). Singapore authorities halted two of the seven brands of fl u vaccinees even though there was no report of death after fl u vaccinations in Singapore. This raises a possibility that there can be a diff erence between the excipients of the fl u vaccinees used in Singapore and in Korea. Our assumptions were that there would have been immunotoxic metals in the fl u vaccinees, the metals would have induced type IV hypersensitivity or Complement Activation-Related Psuedoallergy (CARPA), and would have caused some deaths of 100 persons who incidentally died within 7 days after fl u vaccinations. Methods: In this study, we analyzed twice for the presence of any metal components of aluminum, indium, cadmium, gallium, and mercury in the infl uenza vaccine. Analysis of the metal contents of the 1:29 diluted fl u vaccine was assessed by the Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method. Simultaneously, total 10 BALB/c mice were used to analyze any pathological changes after 7 days of fl u vaccination. Animals were divided into two groups: one group of 5 mice were injected intraperitoneally with 0.1 ml of 1:4 diluted fl u vaccine with injectable distilled water; and the other group of 5 mice were injected intraperitoneally with 0.1 ml of undiluted fl u vaccine. They were freely reared for 7 days in a Polycarbonate cage (400 x 255 x 180 mm). The mice were sacrifi ced after CO2 short-acting gas anesthesia. Brains, hearts, lungs, livers, and kidneys were harvested, prepared with H & E stain, and observed for any histopathological changes. Findings : In one of the cost-free infl uenza vaccinees (Lot Number: A14720017), which were distributed by the Korean Government, the current study detected cadmium 0.12 ppb (parts per billion = μg/L), and mercury 1.77 ppb. But neither aluminum, gallium, nor indium was detected. Both experimental groups showed no demonstrable infl ammatory changes in the specimens of brains, hearts, livers, and kidneys. However, lungs of the undiluted-vaccine-injected group showed signifi cantly more diff use damages than lungs of the 1:4 diluted-vaccine-injected group which showed no to mild infl ammatory changes. The semiquantitative scores of the diluted-vaccine-injected group and the undiluted-vaccine-injected group were 0.7 ± 0.3 and 1.9 ± 0.3, respectively by method one ([a street-view], mean ± SE, p = 0.027 <0.05); and 9.0 ± 1.1 and 18.6 ± 1.6, respectively by method two ([a sky-view], mean ± SE, p < 0.001). Interpretation: Mercury (1.77 ppb) and cadmium (0.12 ppb) were found in the freely distributed infl uenza vaccine by the Korean Government for the season of 2020-2021. Infl ammatory damages in the lungs of experimental mice, which occurred within 7 days after infl uenza vaccination, could be caused by metal-induced type IV hypersensitivity ( delayed-type, T-cell-mediated hypersensitivity) or metal nanoparticle-induced CARPA. In application, metal-induced delayed-type hypersensitivity or metal nanoparticle-induced CARPA could explain some deaths of the 100 persons who unintentionally died within 7 days of infl uenza vaccination by the November 2020 and of the 1,531 persons who coincidentally died within 7 days after Infl uenza vaccination from the fall of 2019 to the spring of 2020 in South Korea, and of the persons who fortuitously died within one week after infl uenza vaccinations in the United States-23.2persons/100,000 vaccinees of an age of over 75 and 11.3 persons/100,000 vaccinees of an age between 65 and 75. The results may be helpful for the causal identifi cation of some deaths of COVID-19 vaccinees.
48
Song, Yejia, and Luiz Belardinelli. "Enhanced basal late sodium current appears to underlie the age-related prolongation of action potential duration in guinea pig ventricular myocytes." Journal of Applied Physiology 125, no. 4 (October 1, 2018): 1329–38. http://dx.doi.org/10.1152/japplphysiol.00916.2017.
Full textAbstract:
Aging hearts have prolonged QT interval and are vulnerable to oxidative stress. Because the QT interval indirectly reflects the action potential duration (APD), we examined the hypotheses that 1) the APD of ventricular myocytes increases with age; 2) the age-related prolongation of APD is due to an enhancement of basal late Na+ current ( INaL); and 3) inhibition of INaL may protect aging hearts from arrhythmogenic effects of hydrogen peroxide (H2O2). Experiments were performed on ventricular myocytes isolated from (young) 1-mo- and (old) 1-yr-old guinea pigs (GPs). The APD of myocytes from old GPs was significantly longer than that from young GPs and was shortened by the INaL inhibitors GS967 and tetrodotoxin. The magnitude of INaL was significantly larger in myocytes from old than from young GPs. The CaMKII inhibitors KN-93 and AIP and the NaV1.5-channel blocker methanethiosulfonate ethylammonium blocked the INaL. There were no significant differences between myocytes from young and old GPs in L-type Ca2+ current and the rapidly and slowly activating delayed rectifier K+ currents, although the inward rectifier K+ current was slightly decreased in myocytes from old GPs. H2O2 induced more early afterdepolarizations in myocytes from old than from young GPs. The effect of H2O2 was attenuated by GS967. The results suggest that 1) the APD of myocytes from old GPs is prolonged, 2) a CaMKII-mediated increase in NaV1.5-channel INaL is responsible for the prolongation of APD, and 3) inhibition of INaL may be beneficial for maintaining electrical stability under oxidative stress in myocytes of old GPs. NEW & NOTEWORTHY The action potential duration is significantly longer in ventricular myocytes from old than from young guinea pigs, which may explain, at the cellular level, the increase in QT interval with age. A CaMKII-mediated enhancement of NaV1.5-channel late current is responsible for the age-related prolongation of action potential duration. The enhanced basal late sodium current may predispose cardiac myocytes of old animals to oxidative stress and arrhythmogenesis.
49
El-Kady, EM, HA El-Shafei, and S. Saleh. "Avian infl uenza." Journal of Vaccines and Immunology 5, no. 1 (November 7, 2019): 022–27. http://dx.doi.org/10.17352/jvi.000026.
Full text
50
Beck, Donald R., and Ziyong Cai. "Bound states inMn−." Physical Review A 37, no. 11 (June 1, 1988): 4481–83. http://dx.doi.org/10.1103/physreva.37.4481.
Full text