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Journal articles on the topic 'Initial-response-evaluation'

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Published: 4 June 2021

Last updated: 20 February 2023

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1

Moran, Simone, and Ilana Ritov. "Initial perceptions in negotiations: evaluation and response to ?logrolling? offers." Journal of Behavioral Decision Making 15, no. 2 (2002): 101–24. http://dx.doi.org/10.1002/bdm.405.

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2

Amioka, Kei, Tomokazu Kawaoka, Masanari Kosaka, Yusuke Johira, Yuki Shirane, Ryoichi Miura, Serami Murakami, et al. "Analysis of Survival and Response to Lenvatinib in Unresectable Hepatocellular Carcinoma." Cancers 14, no. 2 (January 10, 2022): 320. http://dx.doi.org/10.3390/cancers14020320.

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The association between radiological response and overall survival (OS) was retrospectively evaluated in patients treated with lenvatinib as a first-line systemic treatment for unresectable hepatocellular carcinoma. A total of 182 patients with Child–Pugh class A liver function and an Eastern Cooperative Oncology Group performance status of zero or one were enrolled. Radiological evaluation was performed using Response Evaluation Criteria in Solid Tumors (RECIST) and modified Response Evaluation Criteria in Solid Tumors (mRECIST). Initial radiological evaluation confirmed significant stratification of OS by efficacy judgment with both RECIST and mRECIST, and that initial radiological response was an independent prognostic factor for OS on multivariate analysis. Furthermore, in patients with stable disease (SD) at initial evaluation, macrovascular invasion at the initial evaluation on RECIST and modified albumin–bilirubin grade at initial evaluation on mRECIST were independent predictors of OS on multivariate analysis. In conclusion, if objective response is obtained at the initial evaluation, continuation of treatment appears desirable because prolonged OS can be expected; but, if SD is obtained at the initial evaluation, one should determine whether to continue or switch to the next treatment, with careful consideration of factors related to the tumor and hepatic reserve at the initial evaluation.

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3

SOLOWAY, M. S., W. M. MURPHY, D. E. JOHNSON, G. M. FARROW, D. F. PAULSON, and M. B. GARNICK. "Initial Evaluation and Response Criteria for Patients with Superficial Bladder Cancer." British Journal of Urology 66, no. 4 (October 1990): 380–85. http://dx.doi.org/10.1111/j.1464-410x.1990.tb14958.x.

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4

Platzek, Ivan, Bettina Beuthien-Baumann, Jens Langner, Manuel Popp, Georg Schramm, Rainer Ordemann, Michael Laniado, Jörg Kotzerke, and Jörg van den Hoff. "PET/MR for therapy response evaluation in malignant lymphoma: initial experience." Magnetic Resonance Materials in Physics, Biology and Medicine 26, no. 1 (September 16, 2012): 49–55. http://dx.doi.org/10.1007/s10334-012-0342-7.

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5

Claffey, Noel, Bruno Loos, Bernard Gantes, Michael Martin, and Jan Egelberg. "Probing depth at re-evaluation following initial periodontal therapy to indicate the initial response to treatment." Journal of Clinical Periodontology 16, no. 4 (April 1989): 229–33. http://dx.doi.org/10.1111/j.1600-051x.1989.tb01646.x.

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6

Yacoub, Essa, Tuong Huu Le, Kamil Ugurbil, and Xiaoping Hu. "Further evaluation of the initial negative response in functional magnetic resonance imaging." Magnetic Resonance in Medicine 41, no. 3 (March 1999): 436–41. http://dx.doi.org/10.1002/(sici)1522-2594(199903)41:3<436::aid-mrm2>3.0.co;2-#.

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7

KELMER, G., T. J. DOHERTY, S. ELLIOTT, A. SAXTON, M. M. FRY, and F. M. ANDREWS. "Evaluation of dimethyl sulphoxide effects on initial response to endotoxin in the horse." Equine Veterinary Journal 40, no. 4 (June 2008): 358–63. http://dx.doi.org/10.2746/042516408x293501.

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8

Wittgens, Bernd, and Sigurd Skogestad. "Evaluation of Dynamic Models of Distillation Columns with Emphasis on the Initial Response." Modeling, Identification and Control: A Norwegian Research Bulletin 21, no. 2 (2000): 83–103. http://dx.doi.org/10.4173/mic.2000.2.2.

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Wittgens, Bernd, and Sigurd Skogestad. "Evaluation of Dynamic Models of Distillation Columns with Emphasis on the Initial Response." IFAC Proceedings Volumes 28, no. 9 (June 1995): 261–67. http://dx.doi.org/10.1016/s1474-6670(17)47047-9.

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10

Doecke, C. J., D. G. Cosh, and A. S. Gallus. "Standardised initial warfarin treatment: evaluation of initial treatment response and maintenance dose prediction by randomised trial, and risk factors for an excessive warfarin response." Australian and New Zealand Journal of Medicine 21, no. 3 (June 1991): 319–24. http://dx.doi.org/10.1111/j.1445-5994.1991.tb04697.x.

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11

Gordic, Sonja, Octavia Bane, Shingo Kihira, Steven Peti, Stefanie Hectors, Joana Torres, Judy Cho, Jean-Frederic Colombel, and Bachir Taouli. "Evaluation of ileal Crohn’s disease response to TNF antagonists: Validation of MR enterography for assessing response. Initial results." European Journal of Radiology Open 7 (2020): 100217. http://dx.doi.org/10.1016/j.ejro.2020.01.006.

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12

Acevedo Báñez, I., R. Fernández López, I. Borrego Dorado, L. Caballero Gullón, Á. de-Bonilla Damiá, and J. M. Jiménez Hoyuela. "Maxillary myofibroblastic tumor. Initial staging and treatment response evaluation with 18F-FDG PET/CT." Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 38, no. 6 (November 2019): 393–94. http://dx.doi.org/10.1016/j.remnie.2019.06.002.

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13

Frijns, Johan H. M., Jeroen J. Briaire, Jan A. P. M. de Laat, and Jan J. Grote. "Initial Evaluation of the Clarion CII Cochlear Implant: Speech Perception and Neural Response Imaging." Ear and Hearing 23, no. 3 (June 2002): 184–97. http://dx.doi.org/10.1097/00003446-200206000-00003.

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14

HEIJER, PETER, DICK NAGELKERKE, E. JOHN PERRINS, ECKHARD HORSTMANN, RUURD J. WOERSEM, WOLFGANG NIEDERLAG, LUC JORDAENS, et al. "Improved Rate Responsive Algorithm in QT Driven Pacemakers-Evaluation of Initial Response to Exercise." Pacing and Clinical Electrophysiology 12, no. 5 (May 1989): 805–11. http://dx.doi.org/10.1111/j.1540-8159.1989.tb01902.x.

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15

Thibodeaux, J. K., J. D. Roussel, R. W. Adkinson, and L. L. Goodeaux. "The evaluation of pregnancy associated thrombocytopenia as an initial response to pregnancy in cattle." Theriogenology 33, no. 1 (January 1990): 336. http://dx.doi.org/10.1016/0093-691x(90)90760-q.

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16

Baroiu, Liliana, Ana Cristina Lese, Ioana Anca Stefanopol, Alina Iancu, Caterina Dumitru, Alexandru Bogdan Ciubara, Florin Ciprian Bujoreanu, et al. "The Role of D-Dimers in the Initial Evaluation of COVID-19 [Response To Letter]." Therapeutics and Clinical Risk Management Volume 18 (May 2022): 593–94. http://dx.doi.org/10.2147/tcrm.s373236.

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17

Yi, J., S. Kim, S. Lee, S. Park, Y. Ko, J. Choi, and W. Kim. "Clinical usefulness of PET/CT in initial staging and response evaluation of primary gastric lymphoma." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e19541-e19541. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e19541.

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e19541 Background: Positron emission tomography (PET)/computed tomography (CT) scan has a well-established role in the management of non-Hodgkin's lymphoma (NHL). However, in case of the primary gastric lymphoma, which is the most frequent extranodal NHL, the role of PET/CT scan is still controversial. Methods: We retrospectively analyzed 42 patients with primary gastric lymphoma who underwent PET/CT scans; 32 patients with diffuse large B-cell lymphoma (DLBCL) and 10 patients with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) were analyzed. The PET/CT scans were compared with clinicopathologic features and the results of CT and endoscopy. After corresponding treatment, response was evaluated by conventional CT scans or PET/CT scans and endoscopy with biopsy Results: Nine patients were up-staged based on the results of their PET/CT scan compared to CT (7 DLBCL, 2 MALT lymphomas) while six patients were down-staged by the PET/CT scan. The high SUVmax group, defined as SUVmax ≥ median value, was significantly associated with an advanced Lugano stage (P < 0.001). Three patients with DLBCL, who showed an initially high SUVmax, died of disease progression. Although not statistically significant, there was a tendency of inferior outcome in the group with high SUVmax. Among 24 patients for whom follow-up PET/CT scan with endoscopy was performed, 11 patients with ulcerative or mucosal lesions showed residual FDG uptake. All of these gastric lesions were grossly and pathologically benign lesions without evidence of lymphoma cells. Conclusions: PET/CT scan can help staging patients with primary gastric lymphoma, and the maximum SUV has possibility to have prognostic value. However, the residual FDG uptake observed during follow-up should be interpreted cautiously in association with the results of endoscopy and multiple gastric biopsies. No significant financial relationships to disclose.

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Furman‐Haran, Edna, Noam Nissan, Verónica Ricart‐Selma, Carmen Martinez‐Rubio, Hadassa Degani, and Julia Camps‐Herrero. "Quantitative evaluation of breast cancer response to neoadjuvant chemotherapy by diffusion tensor imaging: Initial results." Journal of Magnetic Resonance Imaging 47, no. 4 (September 13, 2017): 1080–90. http://dx.doi.org/10.1002/jmri.25855.

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19

Carroll, William J., Yi Stephanie Zhang, Lee M. Jampol, and Manjot K. Gill. "The Role of Optical Coherence Tomography Angiography in Ranibizumab-Treated Choroidal Neovascularization in Choroidal Osteoma." Case Reports in Ophthalmology 11, no. 2 (July 17, 2020): 370–76. http://dx.doi.org/10.1159/000508032.

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In this study, we report the initial evaluation of choroidal neovascularization (CNV) secondary to choroidal osteoma and subsequent response to anti-vascular endothelial growth factor (anti-VEGF) treatment monitored with optical coherence tomography angiography (OCT-A). A 38-year-old female presented with an initial visual acuity of 20/150 in the left eye. Clinical examination revealed a choroidal osteoma. OCT demonstrated both subretinal and intraretinal fluid. OCT-A was performed and showed CNV. A course of ten treatments with ranibizumab showed an improvement of visual acuity to 20/30–3, improvement of subretinal and intraretinal fluid, as well as attenuation of CNV. Our report demonstrates OCT-A as a useful tool for both initial evaluation of CNV and following treatment response to anti-VEGF therapy.

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20

Glenn, Shaylynn, Cory Butts, Samantha Scarneo-Miller, and William Adams. "Evaluation of Fluid Intake in College Students During the Initial Response to the COVID-19 Pandemic." Current Developments in Nutrition 5, Supplement_2 (June 2021): 222. http://dx.doi.org/10.1093/cdn/nzab029_023.

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Abstract Objectives To evaluate fluid intake of college students during the initial response to the COVID-19 pandemic. Methods College students (n = 1015 (75.5% Female); 59 freshmen, 139 sophomores, 264 juniors, 245 seniors, 289 graduate) participated in an online questionnaire from colleges/universities within the United States during the Spring 2020 academic semester. Participants were asked about their fluid intake over the previous 30 days using the BEVQ-15. The questionnaire consisted of demographic and living status questions as well as 16 questions detailing type (e.g., water, milk, etc.), frequency (“how often”), and volume of fluids for each consumption (“how much each time”). Kruskal-Wallis analyses (test statistic reported as chi-square, χ2) were used to compare the total fluid intake, frequency of plain water intake, and volume with each consumption between those with and without a change in living situation and by academic standing. Data reported as (median [interquartile range]). Results A change in living status was reported by 426/1015 (42%) participants. Median fluid intake was 1848 mL ([1295, 2532] mL) for all participants. Total fluid intake [χ2(1) = 18.07, P < 0.001] was different between those with (1709 [1199, 2366] mL) and without (1940 [1378, 2644] mL) a change in living situation. However, the volume of plain water intake was not different between those with (710 [473, 1420] mL) and without (1065 [591, 1420] mL) a change in living situation [χ2(1) = 2.81, P = 0.09]. Frequency [χ2(1) = 3.10, P = 0.08] and the volume with each consumption [χ2(1) = 1.16, P = 0.28] of plain water were also not different based on a change in living situation. Academic standing impacted the volume of total fluid intake [χ2(4) = 14.33, P = 0.006], with juniors (1751 [1161, 2455] mL) reporting less than graduate students (1940 [1041, 2780] mL, P = 0.01). Conclusions These data suggest a change in living situation affected total fluid intake, however, there were no differences in the frequency and volume of plain water intake. Further, academic standing impacted the fluid intake behaviors. Future investigations are warranted to evaluate factors guiding fluid intake frequency and volumes in the college student population. Funding Sources N/A

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21

Dold, M., G. Fugger, M. Aigner, R. Lanzenberger, and S. Kasper. "Systematic evaluation of dose-escalation strategies after initial non-response to standard-dose pharmacotherapy in schizophrenia." European Psychiatry 41, S1 (April 2017): S193. http://dx.doi.org/10.1016/j.eurpsy.2017.01.2126.

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ObjectivesThis meta-analysis investigates if dose increase of an antipsychotic drug (high-dose treatment, dose escalation) is advantageous for schizophrenic patients who failed to respond adequately to standard-dose treatment with the same antipsychotic.MethodsWithin a systematic literature survey, we identified all randomized controlled trials (RCTs) comparing a dose increase directly to standard-dose continuation treatment in schizophrenic subjects with initial non-response to prospective standard-dose pharmacotherapy with the same antipsychotic. The primary outcome was mean change in the Positive and Negative Syndrome Scale (PANSS) total score. Secondary outcomes were dichotomous response and attrition rates. Study selection and data extraction were conducted independently by two authors. We calculated effect sizes (Hedges's g and risks ratios) using the Mante–Haenszel random-effects model. Meta-regression analyses were performed to explore the influence of the degree of the dose increase on effect sizes.ResultsFive trials (n = 348) examining quetiapine (n = 2, n = 191), ziprasidone (n = 1, n = 75), haloperidol (n = 1, n = 48), and fluphenazine (n = 1, n = 34) were included. We found no significant between-group differences for the mean PANSS/BPRS total score change, even not when itemized according to the individual antipsychotic agents. There were no between-group differences for response and dropout rates. The non-significant meta-regressions indicate no impact of the different amounts of dose increments on effect sizes.ConclusionsWe found no evidence for the efficacy of a dose escalation after initial non-response to standard-dose pharmacotherapy as general advisable treatment strategy. As the high-dose treatment was not accompanied by significant increased attrition rates, appropriate tolerability and acceptability of this pharmacological option can be assumed.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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22

O'Halloran, Kieran. "Corpus-assisted literary evaluation." Corpora 2, no. 1 (May 2007): 33–63. http://dx.doi.org/10.3366/cor.2007.2.1.33.

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Fleur Adcock's poem, Street Song, is evaluated by the stylistician, Roger Fowler, as ‘dynamic and disturbing’. I agree with his literary evaluation. These unsettling effects take place in initial response to the poem, effects which draw me into the work. In other words, they are experienced before proper reflection and analysis of the poem and individual interpretation of it. Implicit within Fowler's evaluation is that this is likely to apply for readers generally. The purpose of this article is to show how empirical corpus evidence can usefully provide substantiation of such initial evaluations of literary works, showing whether or not they are likely to be stereotypically experienced by readers. In drawing on both schema theory and corpus analysis to achieve this, the article makes links between cognitive stylistic and corpus stylistic foci.

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23

Allen, Brian, Edward Florez, Reza Sirous, Seth T. Lirette, Michael Griswold, Erick M. Remer, Zhen J. Wang, et al. "Comparative effectiveness of tumor response assessment methods: Standard-of-care versus computer-assisted response evaluation." Journal of Clinical Oncology 35, no. 6_suppl (February 20, 2017): 432. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.432.

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432 Background: In clinical trials and clinical practice, tumor response assessment with computed tomography (CT) defines critical end points in patients with metastatic disease treated with systemic agents. Methods to reduce errors and improve efficiency in tumor response assessment could improve patient care. Methods: Eleven readers from 10 different institutions independently categorized tumor response according to three different therapeutic response criteria using paired baseline and initial post-therapy CT studies from 20 randomly selected patients with metastatic renal cell carcinoma treated with sunitinib as part of a completed phase III multi-institutional study. Images were evaluated with a manual tumor response evaluation method (standard-of-care) and with computer-assisted response evaluation (CARE) that included stepwise guidance, interactive error-identification and correction methods, automated tumor metric extraction, calculations, response categorization, and data/image archival. A cross-over design, patient randomization, and two-week washout period were used to reduce recall bias. Comparative effectiveness metrics included error rate and mean patient evaluation time. Results: The standard-of-care method was on average associated with one or more errors in 30.5% (6.1/20) of patients while CARE had a 0.0% (0.0/20) error rate (p<0.001). The most common errors were related to data transfer and arithmetic calculation. In patients with errors, the median number of error types was 1 (range 1-3). Mean patient evaluation time with CARE was twice as fast as the standard-of-care method (6.4 vs. 13.1 minutes, p<0.001). Conclusions: Computer-assisted tumor response evaluation reduced errors and time of evaluation, indicating better overall effectiveness than manual tumor response evaluation methods that are the current standard-of-care.

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Easton, P. A., L. J. Slykerman, and N. R. Anthonisen. "Ventilatory response to sustained hypoxia in normal adults." Journal of Applied Physiology 61, no. 3 (September 1, 1986): 906–11. http://dx.doi.org/10.1152/jappl.1986.61.3.906.

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We examined the ventilatory response to moderate (arterial O2 saturation 80%), sustained, isocapnic hypoxia in 20 young adults. During 25 min of hypoxia, inspiratory minute ventilation (VI) showed an initial brisk increase but then declined to a level intermediate between the initial increase and resting room air VI. The intermediate level of VI was a plateau that did not change significantly when hypoxia was extended up to 1 h. The relation between the amount of initial increase and subsequent decrease in ventilation during constant hypoxia was not random; the magnitude of the eventual decline correlated confidently with the degree of initial hyperventilation. Evaluation of breathing pattern revealed that during constant hypoxia there was little alteration in respiratory timing and that the changes in VI were related to significant alterations in tidal volume and mean inspiratory flow (VT/TI). None of the changes was reproduced during a sham control protocol, in which room air was substituted for the period of low fractional concentration of inspired O2. We conclude that ventilatory response to hypoxia in adults is not sustained; it exhibits some biphasic features similar to the neonatal hypoxic response.

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Allen, Brian C., Edward Florez, Reza Sirous, Seth T. Lirette, Michael Griswold, Erick M. Remer, Zhen J. Wang, et al. "Comparative Effectiveness of Tumor Response Assessment Methods: Standard of Care Versus Computer-Assisted Response Evaluation." JCO Clinical Cancer Informatics, no. 1 (November 2017): 1–16. http://dx.doi.org/10.1200/cci.17.00026.

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Purpose To compare the effectiveness of metastatic tumor response evaluation with computed tomography using computer-assisted versus manual methods. Materials and Methods In this institutional review board–approved, Health Insurance Portability and Accountability Act–compliant retrospective study, 11 readers from 10 different institutions independently categorized tumor response according to three different therapeutic response criteria by using paired baseline and initial post-therapy computed tomography studies from 20 randomly selected patients with metastatic renal cell carcinoma who were treated with sunitinib as part of a completed phase III multi-institutional study. Images were evaluated with a manual tumor response evaluation method (standard of care) and with computer-assisted response evaluation (CARE) that included stepwise guidance, interactive error identification and correction methods, automated tumor metric extraction, calculations, response categorization, and data and image archiving. A crossover design, patient randomization, and 2-week washout period were used to reduce recall bias. Comparative effectiveness metrics included error rate and mean patient evaluation time. Results The standard-of-care method, on average, was associated with one or more errors in 30.5% (6.1 of 20) of patients, whereas CARE had a 0.0% (0.0 of 20) error rate ( P < .001). The most common errors were related to data transfer and arithmetic calculation. In patients with errors, the median number of error types was 1 (range, 1 to 3). Mean patient evaluation time with CARE was twice as fast as the standard-of-care method (6.4 minutes v 13.1 minutes; P < .001). Conclusion CARE reduced errors and time of evaluation, which indicated better overall effectiveness than manual tumor response evaluation methods that are the current standard of care.

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Fam, Maged D., Hussein A. Zeineddine, Javed Khader Eliyas, Agnieszka Stadnik, Michael Jesselson, Nichol McBee, Karen Lane, et al. "CSF inflammatory response after intraventricular hemorrhage." Neurology 89, no. 15 (September 8, 2017): 1553–60. http://dx.doi.org/10.1212/wnl.0000000000004493.

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Objective:To investigate the temporal pattern and relevant associations of CSF inflammatory measures after intraventricular hemorrhage (IVH).Methods:We analyzed prospectively collected CSF cell counts and protein and glucose levels from participants in the Clot Lysis Evaluation of Accelerated Resolution of IVH phase III (CLEAR III) trial. Corrected leukocyte count and cell index were calculated to adjust for CSF leukocytes attributable to circulating blood. Data were chronologically plotted. CSF inflammatory measures (daily, mean, median, maximum, and cases with highest quartile response) were correlated with initial IVH volume, IVH clearance rate, thrombolytic treatment, bacterial infection, and adjudicated clinical outcome at 30 and 180 days.Results:A total of 11,376 data points of CSF results from 464 trial participants were analyzed. Measures of CSF inflammatory response evolved during the resolution of IVH. This was significantly more pronounced with initial IVH volume exceeding 20 mL. Intraventricular alteplase was associated with a significantly augmented inflammatory response compared to saline, even after correcting for initial IVH volume. There was an association but nonpredictive correlation of CSF inflammation measures with culture-positive CSF bacterial infection. None of the CSF inflammatory measures, including cases with upper quartile inflammatory response, was associated with a significant detrimental effect on 30 or 180 days functional outcome or mortality after multivariate adjustment for measures of disease severity.Conclusions:Aseptic CSF inflammation after IVH is primarily dependent on the volume of initial bleed. Thrombolysis intensifies the inflammatory response, with no apparent detrimental effect on clinical outcome.Clinicaltrials.gov identifier:NCT00784134.

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Troshina, A. A., I. A. Kolesnikova, Yu V. Kotovskaya, V. S. Moiseev, and Zh D. Kobalava. "Predictors of insufficient response to initial antihypertensive treatment." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 17, no. 6 (December 28, 2011): 525–30. http://dx.doi.org/10.18705/1607-419x-2011-17-6-525-530.

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To compare baseline central pulse wave characteristics in relation to response to initial antihypertensive treatment in previously untreated hypertensive patients. Design and methods. The study included 57 subjects (mean age 50,2 ± 13,7 years) with untreated arterial hypertension grade 1-2 without target organ damage on routine examination. Antihypertensive therapy was initiated after baseline ambulatory blood pressure monitoring (ABPM) and pulse wave analysis. Response to treatment was classified by joint evaluation of ABPM and clinic BP after 8 weeks of treatment. The baseline pulse wave velocity (PWV) was compared in 4 groups: 1) true responders (TR, normal clinic and ambulatory BP), 2) masked responders (MR, elevated clinic and normal ambulatory BP), 3) masked non-responders (MNR, normal clinic and elevated ambulatory BP), 4) true non-responders (TNR, elevated clinic and elevated ambulatory BP). Results. There were 21 (36,8 %) TR, 11 (19,3 %) MR, 11 (19,3 %) MNR, 14 (24,6 %) TNR. MNR was the youngest group but their baseline central systolic, pulse BP and PWV were at least similar or even higher than in the other groups. Conclusion. The results suggest that increased arterial stiffness may be responsible for insufficient response to initial antihypertensive treatment in non-diabetic hypertensive patients.

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Li, Chuan-Yuan, Siqing Shan, Qian Huang, and Mark W. Dewhirst. "Response: Re: Initial Stages of Tumor Cell-Induced Angiogenesis: Evaluation Via Skin Window Chambers in Rodent Models." JNCI: Journal of the National Cancer Institute 92, no. 17 (September 6, 2000): 1445–46. http://dx.doi.org/10.1093/jnci/92.17.1445-a.

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29

Cheson, Bruce D., Richard I. Fisher, Sally F. Barrington, Franco Cavalli, Lawrence H. Schwartz, Emanuele Zucca, and T. Andrew Lister. "Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification." Journal of Clinical Oncology 32, no. 27 (September 20, 2014): 3059–67. http://dx.doi.org/10.1200/jco.2013.54.8800.

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The purpose of this work was to modernize recommendations for evaluation, staging, and response assessment of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A workshop was held at the 11th International Conference on Malignant Lymphoma in Lugano, Switzerland, in June 2011, that included leading hematologists, oncologists, radiation oncologists, pathologists, radiologists, and nuclear medicine physicians, representing major international lymphoma clinical trials groups and cancer centers. Clinical and imaging subcommittees presented their conclusions at a subsequent workshop at the 12th International Conference on Malignant Lymphoma, leading to revised criteria for staging and of the International Working Group Guidelines of 2007 for response. As a result, fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography (CT) was formally incorporated into standard staging for FDG-avid lymphomas. A modification of the Ann Arbor descriptive terminology will be used for anatomic distribution of disease extent, but the suffixes A or B for symptoms will only be included for HL. A bone marrow biopsy is no longer indicated for the routine staging of HL and most diffuse large B-cell lymphomas. However, regardless of stage, general practice is to treat patients based on limited (stages I and II, nonbulky) or advanced (stage III or IV) disease, with stage II bulky disease considered as limited or advanced disease based on histology and a number of prognostic factors. PET-CT will be used to assess response in FDG-avid histologies using the 5-point scale. The product of the perpendicular diameters of a single node can be used to identify progressive disease. Routine surveillance scans are discouraged. These recommendations should improve evaluation of patients with lymphoma and enhance the ability to compare outcomes of clinical trials.

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Uslu-Beşli, L., Y. Akın, and T. F. Çermik. "18 F-FDG PET/CT in initial staging and treatment response evaluation in a patient with thymoma." Revista Española de Medicina Nuclear e Imagen Molecular 36, no. 5 (September 2017): 339–40. http://dx.doi.org/10.1016/j.remn.2017.01.005.

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Uslu-Beşli, L., Y. Akın, and T. F. Çermik. "18 F-FDG PET/CT in initial staging and treatment response evaluation in a patient with thymoma." Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 36, no. 5 (September 2017): 339–40. http://dx.doi.org/10.1016/j.remnie.2017.06.008.

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32

Massafra, Raffaella, Annamaria Catino, Pia Maria Soccorsa Perrotti, Pamela Pizzutilo, Annarita Fanizzi, Michele Montrone, and Domenico Galetta. "Informative Power Evaluation of Clinical Parameters to Predict Initial Therapeutic Response in Patients with Advanced Pleural Mesothelioma: A Machine Learning Approach." Journal of Clinical Medicine 11, no. 6 (March 16, 2022): 1659. http://dx.doi.org/10.3390/jcm11061659.

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Malignant pleural mesothelioma (MPM) is a rare neoplasm whose early diagnosis is challenging and systemic treatments are generally administered as first line in the advanced disease stage. The initial clinical response may represent a useful parameter in terms of identifying patients with a better long-term outcome. In this report, the initial therapeutical response in 46 patients affected with advanced/unresectable pleural mesothelioma was investigated. The initial therapeutic response was assessed by CT scan and clinical examination after 2–3 treatment cycles. Our preliminary evaluation shows that the group of patients treated with regimens including antiangiogenetics and/or immunotherapy had a significantly better initial response as compared to patients only treated with standard chemotherapy, exhibiting a disease control rate (DCR) of 100% (95% IC, 79.40–100%) and 80.0% (95% IC, 61.40–92.30%), respectively. Furthermore, the therapeutic response was correlated with the disease stage, blood leukocytes and neutrophils, high albumin serum levels, and basal body mass index (BMI). Specifically, the patients with disease stage III showed a DCR of 95.7% (95% IC, 78.1–99.9%), whereas for disease stage IV the DCR decreased to 66.7% (95% IC, 34.9–9.1%). Moreover, a better initial response was observed in patients with a higher BMI, who reached a DCR of 96.10% (95% IC, 80.36–99.90%). Furthermore, in order to evaluate in the predictive power of the collected features a multivariate way, we report the preliminary results of a machine learning model for predicting the initial therapeutic response. We trained a state-of-the-art algorithm combined to a sequential forward feature selection procedure. The model reached a median AUC value, accuracy, sensitivity, and specificity of 77.0%, 75%, 74.8%, and 83.3%, respectively. The features with greater informational power were gender, histotype, BMI, smoking habits, packs/year, and disease stage. Our preliminary data support the possible favorable correlation between innovative treatments and therapeutic response in patients with unresectable/advanced pleural mesothelioma. The small sample size does not allow concrete conclusions to be drawn; nevertheless, this work is the basis of an ongoing study that will also involve radiomics in a larger dataset.

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Feinberg, Bruce, James Gilmore, Sally Haislip, Carlos M. Franco, Tom Gondesen, and Mansoor N. Saleh. "Pharmacoeconomic Evaluation of Hypomethylating Agents Used for the Treatment of MDS." Blood 112, no. 11 (November 16, 2008): 2380. http://dx.doi.org/10.1182/blood.v112.11.2380.2380.

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Abstract Introduction. Supportive care has traditionally been the primary treatment for patients with MDS. The approval of hypomethylating agents provides therapeutic options for these patients. However more knowledge about the clinical benefits and associated economic implications in the community setting are required to understand how to best incorporate them into clinical guidelines and protocols. This pharmacoeconomic evaluation was conducted to address critical inputs for this medical decision making process. Method. This evaluation is based on the retrospective analysis of medical and billing records for patients receiving treatment from January, 2006 to December, 2007, in the community setting. Only patients that received initial non-supportive care treatment with a hypomethylating agent decitabine (Dacogen (DAC)) or azacitidine (Vidaza (VID)) were included for this analysis. Due to the progressive nature of this disease, a longitudinal evaluation of the lines of therapy was conducted. Total costs per cycle were defined as the total costs associated with the utilization of hypomethylating agents, other downstream MDS treatments (eg lenalidomide), antiemetics, erythropoietins, WBC growth factors, and transfusions. The costs of antibiotics and antifungals were not included as the established treatment regimens were the same between the specified intervention protocols. The clinical response (CRp) based on available peripheral blood measures with a response being defined as Hgb ≥ 11 g/dL with no transfusions or erythropoietin use, ANC ≥ 1000/μL without the use of WBC growth factors, platelets ≥ 100,000/μL with no thrombopoietic agent, and no blasts for at least 4 weeks. The time to response and transfusion independence were determined by the individual cycles within the lines of therapy. The total and individual cost components were evaluated for each line of therapy based on the sequence of treatment received by cycles. The distribution of clinical response, transfusion independence, and other patient characteristics were analyzed using Chi-square tests and time to response and transfusion was compared using Kaplan-Meier methods. An incremental cost-effective ratio defined as the difference in cost between DAC and VID divided by the difference in CRp or time to response was calculated. Results. A total of 70 patients received initial treatment with either DAC (40) or VID (30). Patients receiving DAC were treated a median of 2.5 cycles of initial treatment while those on VID were treated for a median of 3.5 cycles. No differences in baseline IPSS score were seen. Approximately 43% of those treated with Dacogen had a CRp compared to 13% of patients on VID (p=0.0095). The mean time to response was 105.8 and 130.9 days for DAC and VID, respectively (p=0.0018). The total costs from initial treatment to response were $16,679.19 and $13,954.33 for DAC and VID, respectively (p=0.47). Those with a CRp on DAC had a mean total cost of $34,435.62 compared to $36,852.57 with a CRp on VID with the number of cycles ranging from 2 to 13 for DAC and 8 to 9 for VID. However the mean total cost for those without a response to VID was $23,434.22 compared to $19,111.60 for those not responding to DAC. More patients receiving VID received other MDS agents after initial treatment than those receiving DAC, resulting in increased overall expenses over the remaining treatment period for these patients. The resulting incremental CE ratio based on CRp was $1336.60 per additional successfully treated patient while the incremental CE ratio using time to response was $108.56/day. Discussion. Hypomethylating agents provide clinicians with necessary alternatives to traditional supportive care in the treatment of patients with MDS. Due to faster time to clinical response, Dacogen appears to have both a short- and long-term pharmacoeconomic advantage over Vidaza. Extended observation of patients and length of treatment is needed to understand the long-term ramifications for incorporation into clinical guidelines and protocols.

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Desimone, Roberto, and John Mark Agosta. "DECISION SUPPORT FOR OIL SPILL RESPONSE CONFIGURATION PLANNING." International Oil Spill Conference Proceedings 1995, no. 1 (February 1, 1995): 936–37. http://dx.doi.org/10.7901/2169-3358-1995-1-936.

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ABSTRACT We have developed a prototype oil spill response configuration system to help U. S. Coast Guard (USCG) planners determine the appropriate response equipment and personnel for major spills. Advanced artificial intelligence planning techniques, as well as other software tools, have been applied to spill trajectory modeling, plan evaluation, and map display. We have successfully demonstrated the initial prototype system to various USCG personnel at the regional and national levels on a specific major spill scenario from the San Francisco Bay area.

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Fu, Wei, Wan Ping Wu, Sha Wu, Bin He, and Yan Bin Ruan. "Research on the Swelling Characteristics of Expansive Soil." Advanced Materials Research 250-253 (May 2011): 1761–64. http://dx.doi.org/10.4028/www.scientific.net/amr.250-253.1761.

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Swelling tests of remolded expansive soil with water immersing are carried out by use of the simple consolidometers. The swelling characteristics of the expansive soil under the different initial conditions are studied. The Dose Response model is used to fit the rules of swelling time interval for expansive soil with water immersing. The quantitative relationship among the swelling and initial overburden pressure, initial water content and initial dry density is attained by use of the three dimensional regression analyses. The important index obtained could be provided to the engineering design, construction and stability evaluation of expansive soil slopes.

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Zhou, Ying Xin, Chuan Tang, Ming Zhang, Rui Qiang Yue, Yong Ma, Hong Yang, Shao Lin Fang, Zhong Lin Tang, Wen Jiang Jiang, and Dan Dan Li. "Study on Expansion and Deformation Characteristics of Expansive Soil in Yunnan Province." Applied Mechanics and Materials 204-208 (October 2012): 37–40. http://dx.doi.org/10.4028/www.scientific.net/amm.204-208.37.

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Swelling tests of remolded expansive soil with water immersing are carried out by use of the simple consolidometers. The swelling characteristics of the expansive soil under the different initial conditions are studied. The Dose Response model is used to fit the rules of swelling time interval for expansive soil with water immersing. The quantitative relationship among the swelling and initial overburden pressure, initial water content and initial dry density is attained by use of the three dimensional regression analyses. The important index obtained could be provided to the engineering design, construction and stability evaluation of expansive soil slopes.

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Adaiyi, Obene Tonye, Abhulimen Victor , and Echem Richard . "Evaluation of Gunshot Wounds to the Extremities: Correlation of Red Cross Wound Score and Initial Response to Management." American Journal of Health, Medicine and Nursing Practice 7, no. 11 (September 14, 2022): 9–21. http://dx.doi.org/10.47672/ajhmn.1191.

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Purpose: Gunshot wounds to the extremities are a major cause of death and disability. The Red Cross Wound Score (RCWS) is a simple classification system that is thought to fairly assess severity of injury, influence surgical management and a good predictor of outcome in gunshot wounds. This study aims to evaluate the correlation between the Red Cross Wound Score RCWS and initial response to management. Methodology: This was a prospective study recruiting all consenting patients who suffered gunshot wounds to any extremity and presented at the University of Port Harcourt Teaching Hospital (UPTH). The study was conducted over a 12-month period between October 2018 and September 2019. Data on demographics, anatomical region of the body involved, type of gun time between injury and hospital presentation were obtained using a proforma. Analysis of extracted data was done by the aid of SPSS for Windows version 20. Findings: A total of 106 wounds from 82 patients were analyzed; seventy males (85.4%) and 12 females. AK 47 rifles and locally fabricated pistols were the wounding weapons in 32.9% and the left leg (28.3%) was the most injured extremity. Fifty-two wounds (49%) were grade 3, 44 (41.5%) wounds grade 2 and 10 wounds (9.4%) grade 1. There was a positive association between RCWS grade 3 wounds and limb length discrepancy and joint stiffness. Vascular injuries were seen in 6 patients (0.07%). Wound infection (46.2%), joint stiffness (41.5%) and shortening (34%) were the common complications in the study. The study showed that young adult males suffered more gunshot wounds than females. Most of the wounds were RCWS grade 3 and there was a positive association between RCWS grade 3 wounds and limb length discrepancy and joint stiffness. Patients with longer mean presentation time had a higher infection rate. Recommendations: The Red Cross wound classification should be adopted as a useful scoring system. Also, patients with gunshot injuries should present earlier to the hospital to reduce complications.

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Amri, Boutheina, and Nadia Menazla. "Obamacare During the Pandemic: A Historical, Economic and Sociopolitical Evaluation of the Initial Response of the US Government." Technium Social Sciences Journal 33 (July 9, 2022): 638–47. http://dx.doi.org/10.47577/tssj.v33i1.6839.

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This review of literature is an account of the US government initial response to the 2020 outbreak. The Affordable Care Act was, more so than ever, put to the test in the Covid -19 era with questions about its efficiency in healthcare delivery in this unforeseen state of emergency. This paper opted for a combination of historical and analytical reviews of literature about the American healthcare system to showcase the sociopolitical and economic implications of the COVID -19 pandemic in the earliest months of the outbreak. This study enunciates the weaknesses of federal actions in dealing with the health crisis and the dilemma of the millions of Americans who belong to minority ethnic groups who awaited equity and fast action to protect them from the severe consequences of the pandemic and the resulting recession. This investigation concluded that the ACA which was once an ambitious and very promising health care reform is struggling today to keep up with the alarming growing numbers of the uninsured or under-insured vulnerable sections of the population that it was originally designed enacted to protect. The pandemic was a very important reminder that healthcare in America is in dire need for an overarching reform. This study is a needed document that explains how healthcare in America proved once more to fail millions of Americans in a very important turning point in the recent history of healthcare delivery.

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Cabassa, P., L. Romanini, M. Cristinelli, D. Ceriani, and E. Dilda. "Contrast-enhanced harmonic sonography in the evaluation of therapeutic response to radiofrequency ablation of hepatocellular carcinoma. initial report." Ultrasound in Medicine & Biology 29, no. 5 (May 2003): S24—S25. http://dx.doi.org/10.1016/s0301-5629(03)00152-2.

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Tsai, Ya-Ju, Yi-Hsiang Lin, Chung-Huei Hsu, and Shauh-Der Yeh. "18F-fluorodeoxyglucose positron emission tomography for the initial evaluation and monitoring of therapeutic response in bilateral adrenal histoplasmosis." Clinical Imaging 37, no. 4 (July 2013): 791–93. http://dx.doi.org/10.1016/j.clinimag.2013.02.011.

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Yuan, Zheng, Xiao-Dan Ye, Sheng Dong, Li-Chao Xu, and Xiang-Sheng Xiao. "Evaluation of Early Imaging Response After Chemoembolization of Hepatocellular Carcinoma by Phosphorus-31 Magnetic Resonance Spectroscopy—Initial Experience." Journal of Vascular and Interventional Radiology 22, no. 8 (August 2011): 1166–73. http://dx.doi.org/10.1016/j.jvir.2011.04.010.

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Ning, Ping, Yue Hong Yang, Dun Tao Shu, Lei Shi, and Yang Cheng. "The Application of Response Surface Methodology for Adsorption Optimization of Lead (II) onto Phosphogypusum." Advanced Materials Research 955-959 (June 2014): 2026–31. http://dx.doi.org/10.4028/www.scientific.net/amr.955-959.2026.

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Using the phosphogypsum as adsorbent prepared from microwave modified for the removal of lead ions from aqueous solution has been investigated under optimized conditions in this study. Influences of parameters like adsorbent dose 0.5-1.5g/100mL, initial concentration of ions 20–60 mg/L , pH 5.0–7.0 and temperature 20–30°C on Pb ions adsorption were also examined, using Box-Behnken design matrix. Very high regression coefficient between the variables and the response indicates excellent evaluation of experimental data by second order polynomial regression model. The response surface method indicated that adsorbent dose 1.0g/100mL, initial concentration of ions 40mg/L , pH 7.0 and temperature 20°C were optimal for adsorption of Pb ions .

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Lee, Hee Seung. "Chemotherapy: Knowing When to Start, Evaluate for Response, and Stop." Korean Journal of Pancreas and Biliary Tract 25, no. 1 (January 31, 2020): 40–45. http://dx.doi.org/10.15279/kpba.2020.25.1.40.

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Chemotherapy is essential treatment in pancreatobiliary cancer patients. Knowing optimal time of chemotherapy initiation is important. Usually good performance status and general condition without jaundice is first recommendation for initiating chemotherapy. Good performance status is defined as Eastern Cooperative Oncology Group 0-1, with good biliary drainage and adequate nutritional intake. Percutaneous or endoscopic biliary drainage is recommended before chemotherapy in patient who shows high bilirubin level. The optimal timing of chemotherapy after diagnosis is not standardized but guideline recommends chemotherapy less 2 months after initial cancer diagnosis. Regard to chemotherapy response evaluation, Response Evaluation Criteria in Solid Tumors criteria is used per 2-3 months. Response Evaluation Criteria in Solid Tumors criteria evaluate the chemotherapy responsiveness. With regular tumor response, clinicians must determine whether patient can undergo chemotherapy continuously without complication. For example, Eastern Cooperative Oncology Group 3 or poor general condition make patient not to undergo chemotherapy and focus on end-of-life care. As a result, knowing about the start and stop of chemotherapy can help relieve the patient's symptoms, prolong survival and improve the quality of life.

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Cąkała-Jakimowicz, Marta, and Monika Puzianowska-Kuznicka. "Towards Understanding the Lymph Node Response to Skin Infection with Saprophytic Staphylococcus epidermidis." Biomedicines 10, no. 5 (April 28, 2022): 1021. http://dx.doi.org/10.3390/biomedicines10051021.

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In individuals with lymphedema, diabetic foot, or other diseases, infections with saprophytes are common. The response of major cell subpopulations in the draining lymph nodes to skin infection with Staphylococcus epidermidis was assessed using the rat model. After massive subepidermal infection, a cytometric evaluation showed an increase in cytotoxic and helper T lymphocytes and major subpopulations of the innate immune response. Three weeks later, signs of inflammation reduction with an increase in the content of memory T helper lymphocytes and effector memory T cytotoxic lymphocytes were observed. After skin re-infection, a rapid response of cytotoxic, helper, and memory T lymphocytes, memory B lymphocytes and plasmablasts, and macrophages was detected. In addition, a reduction in the number of naïve B lymphocytes, activated MHC class II+ cells, and some cells of the innate immune system was observed. T regulatory lymphocyte response after the initial and secondary S. epidermidis skin infection was not detected. The morphometric evaluation showed significant changes in the main cell subpopulations in each functional zone of the node and then confirmed the efficient elimination of the administered antigen, as evidenced by the observations on day 28. Notably, after re-infection, the cellular response did not exceed the level after the initial infection and was reduced in many cell subpopulations. Understanding how the lymph nodes eliminate S. epidermidis can provide valuable insights into creating immunological therapies against infections with saprophytes.

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Ruzek, Josef I., Melissa J. Brymer, Anne K. Jacobs, Christopher M. Layne, Eric M. Vernberg, and Patricia J. Watson. "Psychological First Aid." Journal of Mental Health Counseling 29, no. 1 (January 1, 2007): 17–49. http://dx.doi.org/10.17744/mehc.29.1.5racqxjueafabgwp.

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Psychological First Aid (PFA) consists of a systematic set of helping actions aimed at reducing initial post-trauma distress and supporting short- and long-term adaptive functioning. Designed as an initial component of a comprehensive disaster/trauma response, PFA is constructed around eight core actions: contact and engagement, safety and comfort, stabilization, information gathering, practical assistance, connection with social supports, information on coping support, and linkage with collaborative services. PFA for children and adolescents focuses on these same core actions, with modifications to make them developmentally appropriate. Formal evaluation of the effectiveness of PFA is needed and it is hoped that development of a PFA Field Operations Guide will facilitate such evaluation.

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Bode, H., and C. F. Seyfried. "Mixing and Detention Time Distribution in Activated Sludge Tanks." Water Science and Technology 17, no. 2-3 (February 1, 1985): 197–208. http://dx.doi.org/10.2166/wst.1985.0130.

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The interrelationship between mixing characteristics and tracer response curves in activated sludge tanks is explained. In some cases the return sludge cycle has a strong influence on the tracer response curves. Results from tracer tests in the field are hard to interpret because the tracer in the return sludge interferes with the initial tracer. Therefore a special evaluation procedure has to be applied. The paper closes with results from a field tracer test study.

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Serin, İstemi, Mehmet Hilmi Doğu, Vahit Can Çavdar, and Elif Suyani. "Evaluation of the Relationship Between Initial Lymphocyte Count and Molecular Response to Imatinib Therapy in Chronic Myeloid Leukaemia Patients." Istanbul Medical Journal 21, no. 6 (November 13, 2020): 473–76. http://dx.doi.org/10.4274/imj.galenos.2020.46690.

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Gallego, A., J. Sheldon, J. García-Samaniego, N. Margall, M. Romero, P. Hornillos, V. Soriano, and J. Enríquez. "Evaluation of initial virological response to adefovir and development of adefovir-resistant mutations in patients with chronic hepatitis B." Journal of Viral Hepatitis 15, no. 5 (May 2008): 392–98. http://dx.doi.org/10.1111/j.1365-2893.2008.00966.x.

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Agnani, G., R. Ramanah, A. S. Tholozan, A. L. Dubourdeau, A. Berdin, and F. Mauny. "Anti-mullerian hormone evaluation and initial ovarian response in an apparently good prognosis population treated by intracytoplasmic sperm injection." Fertility and Sterility 98, no. 3 (September 2012): S177—S178. http://dx.doi.org/10.1016/j.fertnstert.2012.07.652.

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MacRae, Amelia Mari, I. Joanna Makowska, and David Fraser. "Initial evaluation of facial expressions and behaviours of harbour seal pups (Phoca vitulina) in response to tagging and microchipping." Applied Animal Behaviour Science 205 (August 2018): 167–74. http://dx.doi.org/10.1016/j.applanim.2018.05.001.

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