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1

Iqbal, Choudhary Muhammad, ed. Biological inhibitors. Amsterdam: Harwood Academic Publishers, 1996.

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2

Zollner, Helmward. Handbook of enzyme inhibitors. 2nd ed. Weinheim, Federal Republic of Germany: VCH, 1993.

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3

Zollner, Helmward. Handbook of enzyme inhibitors. 3rd ed. Weinheim: New York, 1999.

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4

Zollner, Helmward. Handbook of enzyme inhibitors. Weinheim, Federal Republic of Germany: VCH, 1989.

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5

Laufer, Stefan, ed. Proteinkinase Inhibitors. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68180-7.

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6

D’Orléans-Juste, Pedro, and Gérard E. Plante, eds. ACE Inhibitors. Basel: Birkhäuser Basel, 2001. http://dx.doi.org/10.1007/978-3-0348-7579-0.

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7

Kuster, Bernhard, ed. Kinase Inhibitors. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-337-0.

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8

Furr, Barrington J. A., ed. Aromatase Inhibitors. Basel: Birkhäuser Basel, 2006. http://dx.doi.org/10.1007/3-7643-7418-7.

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Furr, Barrington J. A., ed. Aromatase Inhibitors. Basel: Birkhäuser Basel, 2008. http://dx.doi.org/10.1007/978-3-7643-8693-1.

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10

Hayes, Teresa L. Corrosion inhibitors. Cleveland, Ohio: Freedonia Group, 2002.

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11

A, Furr B. J., ed. Aromatase inhibitors. Basel: Birkhäuser, 2006.

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12

1928-, Laskin Allen I., and Lechevalier Hubert A, eds. Antimicrobial inhibitors. 2nd ed. Boca Raton, Fla: CRC Press, 1988.

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13

Innes, George L. Corrosion inhibitors. Norwalk, CT: Business Communications Co., 1999.

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14

Donald, Saxman, and Business Communications Co, eds. Corrosion inhibitors. Norwalk, CT: Business Communications Co., 1993.

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15

Baumgartner, William G. Corrosion inhibitors. Cleveland, Ohio: Freedonia Group, 1997.

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16

J, Barrett Alan, and Salvesen G, eds. Proteinase inhibitors. Amsterdam: Elsevier, 1986.

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17

1957-, D'Orléans-Juste P., and Plante G. E, eds. ACE inhibitors. Basel: Birkhäuser Verlag, 2001.

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18

Jiang, Shibo, and Lu Lu, eds. Virus Entry Inhibitors. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8702-0.

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19

Gupta, Satya Prakash, ed. Matrix Metalloproteinase Inhibitors. Basel: Springer Basel, 2012. http://dx.doi.org/10.1007/978-3-0348-0364-9.

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20

Mellinghoff, Ingo K., and Charles L. Sawyers, eds. Therapeutic Kinase Inhibitors. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28296-6.

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21

Higgs, Gerry A., and Brian Henderson, eds. Novel Cytokine Inhibitors. Basel: Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8450-1.

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22

Sastri, V. S. Green Corrosion Inhibitors. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118015438.

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23

Weinberg, Jeffrey M., and Robin Buchholz, eds. TNF-alpha Inhibitors. Basel: Birkhäuser-Verlag, 2006. http://dx.doi.org/10.1007/3-7643-7438-1.

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24

Pairet, Michel, and Joanne van Ryn, eds. COX-2 Inhibitors. Basel: Birkhäuser Basel, 2004. http://dx.doi.org/10.1007/978-3-0348-7879-1.

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25

Supuran, Claudiu T., and Clemente Capasso, eds. Zinc Enzyme Inhibitors. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-46112-0.

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26

Hjalmarson, Å., and W. J. Remme, eds. Sinus node inhibitors. Heidelberg: Steinkopff, 1991. http://dx.doi.org/10.1007/978-3-642-72458-9.

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27

Olbe, Lars, ed. Proton Pump Inhibitors. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8795-3.

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28

Lars, Olbe, ed. Proton pump inhibitors. Basel: Birkhauser, 1999.

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29

S, Stokes G., Marwood J. F. 1946-, and International Congress of Pharmacology (10th : 1987 : Sydney, N.S.W.), eds. Sodium transport inhibitors. Basel: Karger, 1988.

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30

name, No. HMG-CoA reductase inhibitors. Basel: Birkhuser Verlag, 2003.

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31

McAlpine, Shelli R., and Adrienne Lesley Edkins, eds. Heat Shock Protein Inhibitors. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32607-8.

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32

Warner, Timothy D., ed. Endothelin and Its Inhibitors. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56899-2.

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33

Page, Clive, Christian Schudt, Gordon Dent, and Klaus F. Rabe. Phosphodiesterase Inhibitors. Elsevier Science & Technology Books, 1996.

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34

Inamuddin, ed. Sustainable Corrosion Inhibitors. Materials Research Forum LLC, 2021. http://dx.doi.org/10.21741/9781644901496.

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35

Fleischmann, Roy. Signalling pathway inhibitors. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081.

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Abstract:
Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and SyK pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Tofacitinib is an orally administered small-molecule inhibitor that targets the intracellular Janus kinase 3 and 1 (JAK1/3) molecules to a greater extent than JAK2 while baricitinib (formerly INCB028050) predominantly inhibits JAK1/2. Many of the proinflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK-STAT signalling, by targeting multiple RA-associated cytokine pathways, has the potential to simultaneously reduce inflammation, cellular activation, and proliferation of key immune cells. Fostamatinib disodium is an orally available inhibitor of spleen tyrosine kinase (SyK), which is a cytoplasmic tyrosine kinase that is an important mediator of immunoreceptor signalling in mast cells, macrophages, neutrophils, and B cells. Interruption of SyK signalling may interrupt production of tumour necrosis factor (TNF) and metalloproteinase and therefore affect RA disease activity. Tofacitinib has been investigated in multiple phase 2 and phase 3 trials which have investigated its efficacy (clinical, functional, and radiographic) and safety in patients who have failed disease-modifying anti-inflammatory drugs (DMARDs) as monotherapy or in combination with DMARDs, compared to an inhibitor of tumour necrosis factor alpha (TNFα‎) and in patients who have failed TNFα‎ inhibitors. The efficacy of fostamatinib and baricitinib has been investigated in phase 2 trials; both are in large phase 3 clinical programmes. Each of these medications has demonstrated efficacy; their safety profile has been shown to be different from each other and from currently approved biological agents. This chapter discusses what is currently known and understood about their efficacy and safety.
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36

Choudhary, M. Iqbal. Biological Inhibitors. Taylor & Francis Group, 2020.

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37

Brodie, Angela, J. Michael Dixon, Robert Paridaens, Miller William R, and B. J. A. Furr. Aromatase Inhibitors. Springer London, Limited, 2006.

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38

Fantacuzzi, Marialuigia, and Alessandra Ammazzalorso, eds. Anticancer Inhibitors. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-4919-4.

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39

Phosphodiesterase Inhibitors. Elsevier, 1996. http://dx.doi.org/10.1016/b978-0-12-210720-7.x5000-x.

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40

Singh, Ambrish, ed. Corrosion Inhibitors. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.76742.

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41

Savino, Rocco. Cytokine Inhibitors. CRC Press LLC, 2001.

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42

Singh, Ambrish. Corrosion Inhibitors. IntechOpen, 2019.

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43

D'Orleans-Juste, Pedro. Ace Inhibitors. Island Press, 2001.

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44

D'Orléans-Juste, Pedro, and G. E. Plante. ACE Inhibitors. Birkhauser Verlag, 2012.

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45

Ciliberto, Gennaro. Cytokine Inhibitors. Taylor & Francis Group, 2000.

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46

Ciliberto, Gennaro. Cytokine Inhibitors. Taylor & Francis Group, 2000.

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47

GOUDOT. Metabolic Inhibitors. John Wiley & Sons Inc, 1993.

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48

Laufer, Stefan. Proteinkinase Inhibitors. Springer International Publishing AG, 2021.

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49

Corrosion Inhibitors. NACE International: The Corrosion Society, 1994.

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50

Ciliberto, Gennaro. Cytokine Inhibitors. Taylor & Francis Group, 2000.

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