Contents
Academic literature on the topic 'Inhibiteur de la liaison au diazépam'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Inhibiteur de la liaison au diazépam.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Inhibiteur de la liaison au diazépam"
FABRE-NYS, C. "Le comportement sexuel des caprins : contrôle hormonal et facteurs sociaux." INRAE Productions Animales 13, no. 1 (February 18, 2000): 11–23. http://dx.doi.org/10.20870/productions-animales.2000.13.1.3764.
Full textFillion, G., C. Harel, I. Cloez, P. Barone, F. Atger, MP Fillion, N. Prudhomme, et al. "Récepteurs sérotoninergiques 5-HT1D et antidépresseurs." Psychiatry and Psychobiology 5, no. 3 (1990): 187–94. http://dx.doi.org/10.1017/s0767399x00003485.
Full textDissertations / Theses on the topic "Inhibiteur de la liaison au diazépam"
Li, Sijing. "Critical role of ACBP/DBI in hepatocellularcarcinogenesis." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL021.
Full textThe curative options are limited to early-stage HCC (surgery), while HCC is often diagnosed at advanced stages. Other treatment strategies mostly have (at best) a temporary impact on disease progression with limited effect on long-term outcomes. Acyl coenzyme A binding protein (ACBP) encoded by diazepam binding inhibitor (OBI) is involved in various human diseases, while its function and mechanisms remain elusive. Three different in vivo models combined with three kinds of ACBP/DBI inhibition strategies associated with several multi-omics approaches were used to explore the implication of ACBP/DBI in HCC. OBI mRNA was consistently overexpressed in tumor versus non-tumor tissues in public HCC datasets, and high OBI mRNA levels were associated with poor outcomes in HCC patients. ACBP/DBI inhibition mitigated hepatocarcinogenesis in all the in vivo models. Bulk RNA-seq data suggested that ACBP/DBI inhibition dysregulated genes involved in cell cycle, proliferation, cell death (ferroptosis, autophagy, apoptosis, or necrosis) and immunosuppressive-related pathways. qRT-PCR, immunoblot and immunofluorescence analyses indicated that ACBP/BDI inhibition downregulated genes required for cell cycle advancement and upregulated genes that black the cell cycle confirming the anti-proliferation effects of ACBP/DBI inhibition. Further, we confirmed the upregulation of ferroptosis driver and downregulation of ferroptosis suppressor bath at mRNA and protein levels upon ACBP/DBI inhibition. Moreover, ACBP/DBI inhibition increased HCC responses to PD-1 blockade, and sensitized HCC to the therapeutic induction of ferroptosis in several functional studies. Ali these results suggest that ACBP/DBI constitutes an actionable target involved in HCC pathogenesis
Montégut, Léa. "Role of acyl-coenzyme A binding protein in age-related diseases and cancer." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL073.
Full textAcyl-coenzyme A binding protein (ACBP), also known as diazepam binding inhibitor (DBI), is a ubiquitous and highly conserved protein in eukaryota. In mammals, it plays a dual role: intracellular ACBP binds to activated fatty acids (acyl-CoAs) and, when secreted, ACBP acts as a peptide hormone regulating metabolism and obesity. The analysis of publicly available datasets demonstrates a tendency for increased ACBP in physio-pathological contexts, such as hepatic steatosis, severe forms of HIV or COVID-19, and certain cancers. Additionally, plasma ACBP concentrations are positively correlated with chronological age.Recent studies in mice have shown that modulation of circulating ACBP levels can also control metabolic parameters in animals. Obesity and metabolic syndrome are among the primary environmental risk factors for the development of age-related diseases, such as cardiovascular diseases and cancer, therefore our research aimed to determine if these diseases could be preceded by a modification in circulating ACBP levels.In cohorts of apparently healthy of individuals, we detected an elevation of ACBP in patients who would imminently develop cardiovascular events or cancer. The utility of this aging biomarker was further explored in different preclinical contexts. On one hand, neutralization of the protein extends the lifespan of yeast and, in mice, it protects against accelerated aging of the heart caused by anthracyclines (a class of chemotherapies commonly used and known for their cardiotoxic effects). In the context of cancer, modulation of this metabolic checkpoint has a positive impact on tumor immunosurveillance and improves the response to chemotherapy-immunotherapy treatments in mice. Thus, our study reveals that ACBP could be a biomarker of patients' "biological age,", with its elevation indicating the imminent onset of age-related diseases. Beyond its predictive value, initial preclinical trials demonstrate that neutralization of ACBP is a promising option for improving metabolic health in patients, which could be exploited to prevent or enhance the response to treatments for cardiovascular diseases and cancer
Descombes, Jean-Jacques. "Etude de la liaison spécifique aux récepteurs alpha-adrénergiques de cellules musculaires lisses vasculaires." Strasbourg 1, 1987. http://www.theses.fr/1987STR13074.
Full textVaugeois, Jean-Marie. "Caractéristiques de la liaison in vivo chez la souris d'un inhibiteur de la capture de dopamine le [3H]GBR 12783." Rouen, 1992. http://www.theses.fr/1992ROUES001.
Full textGros, Guillaume. "La liaison réversible NCO appliquée aux domaines de l'inhibition d'enzymes et des oligomères bio-mimétiques." Thesis, Lyon, École normale supérieure, 2015. http://www.theses.fr/2015ENSL0983/document.
Full textThis thesis relates the research performed on the design and synthesis of a new type of HIV-1 protease inhibitors and a new archetype of a bio-mimetic foldamer based on an unusual interaction, the NCO interaction. This interaction occurs between a tertiary amine and a carbonyl group in highly polar and protic media, such as aqueous media. The first half of my work focused on the development of a modular synthesis towards candidates for the inhibition of HIV-1 protease. This research enabled us to work on large scale and to be able to modify at will most of the candidates’ functions. Seven new inhibitors were isolated and tested in vitro and in cellulo with an original method, in collaboration with Lorena Martinez and Pierre Falson, from the Institute of Biology and Chemistry of Proteins (IBCP). The second half of my work was dedicated to the design of a new backbone for a bio-mimetic oligomer. A few strategies were explored and a monomer was chosen to be oligomerized. The coupling enabled the isolation of a tetramer. Unfortunately, serious purification issues limited the quantity of the previous tetramer and no foldamer study could be performed. The work presented here are the synthesis’ optimization and the perspectives to overcome the purification issues. In addition, a new process for the synthesis 1,4,7-triazacyclononanes displaying a 2Ra/Rb N-substitution pattern was developed from diethylenetriamine in only four steps. This work was patented during this PhD
Refahi-Lyamani, Fatima. "Etude comparative des radicaux impliqués dans la liaison spécifique de la 3H cocaïne et dans celle d'un inhibiteur spécifique de capture neuronale de la dopamine, 3H GBR 12783." Rouen, 1994. http://www.theses.fr/1994ROUES081.
Full textDo, Rego Marie Jean-Claude. "Etude du site et du mode de liaison des inhibiteurs du transporteur neuronal de la dopamine ; caractérisation et utilisation d'un inhibiteur irréversible afin de mesurer la vitesse de renouvellement du transporteur." Rouen, 2000. http://www.theses.fr/2000ROUES017.
Full textAmejdki-Chab, Nassira. "Effets des ions sur le transport neuronal de la dopamine et sur la liaison des inhibiteurs et des substrats au transporteur, étudiée à l'aide d'un marqueur spécifique, le [3H] GBR 12783." Rouen, 1991. http://www.theses.fr/1991ROUES042.
Full textCorera, Amadou Tidjane. "Effets des ions sur la capture de [3H]dopamine et sur la liaison des substrats et des inhibiteurs au transporteur neuronal de la dopamine marqué avec le [3H]WIN 35428 ou le [3H]Mazindol." Rouen, 2000. http://www.theses.fr/2000ROUES008.
Full textSaadouni, Saïda. "Participation à l'étude des radicaux impliqués dans la liaison spécifique des deux inhibiteurs tritiés au transporteur neuronal de la dopamine : [3H] GBR 12783 et [3H] cocaïne." Rouen, 1993. http://www.theses.fr/1993ROUES047.
Full text