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Caldana, Cleber Gomes. "Infusion." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/85828.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.Made available in DSpace on 2012-10-20T23:49:24Z (GMT). No. of bitstreams: 1 233636.pdf: 329112 bytes, checksum: eb1bfba0eb0b8cef61f63cd5dbab5ecd (MD5)
Este trabalho apresenta um estudo sobre métodos de engenharia reversa para Sistemas Legados. Sistemas Legados caracterizam-se por apresentarem elevado custo de manutenção devido a não utilização dos conceitos de engenharia de software e são mantidos por desenvolvedores que não participaram da sua concepção. A Engenharia Reversa surge como uma abordagem para melhorar a manutenção de Sistemas Legados através de estudos sobre o código fonte e a documentação existente, caso exista, revitalizando a documentação inerente as etapas de Análise e Projeto, recuperando assim o entendimento do sistema. Também é apresentado um estudo de caso baseado no método de Engenharia Reversa FUSION/RE. O desenvolvimento do estudo de caso é descrito através de documentações geradas e dos procedimentos aplicados durante a aplicação do método FUSION/RE na Engenharia Reversa. Como contribuições deste trabalho são apresentadas alterações nos procedimentos do método FUSION/RE e uma proposta de validação da documentação gerada durante o processo de Engenharia Reversa. This work represents a study about Reverse Engineering for Legacy Systems.Legacy Systems are caracterized by high cost of maintenance due to the nonutilization of software engineering concepts, and are kept updated by developers that do not participated of the conception of the System. The Reverse Engineering emerge as an approach to improve the maintenance of the Legacy Systems through studies over the source code and the documentation, case it exists, revitalizing the documentation to the phases of Analysis and Project, recovering this way the understanding of the system. It is also presented a case study based on the FUSION/RE Reverse Engineering method. The development of the case study is described throuhg documentation generated and the procedures applied during the application of the FUSION/RE method on the Reverse Engineering. The contributions of this work focus on the alterations to the procedures on the FUSION/RE method and to a proposal of validation of the documentation generated during the Reverse Engineering proccess.
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Casas, Ormeño Camila Alexandra, Nuñez Carlos Eduardo Ortiz, Barboza Ximena Alexandra Prado, Dias Fiorella del Pilar Salazar, and Barrantes Adriana Stefhany Sarmineto. "Proyecto SANI." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/652293.
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El presente proyecto de una infusión 100% natural a base de hoja de Jamaica, piña deshidratada y canela, que ayuda a las mujeres a combatir los molestos síntomas de la menstruación, tales como el dolor de cabeza, los cólicos y la ansiedad. La base de nuestro filtrante tiene propiedades anticoagulante, antioxidante y de relajación. En el presente trabajo se dará a conocer cómo fue identificado el problema y cómo detectamos la solución, para quienes y cómo acercarnos a ellas. Se encontró que las mujeres tienen una baja productividad en el trabajo o en los estudios cuando se encuentran en su periodo menstrual. Por ultimo, validamos nuestras hipótesis mediante entrevistas personales y focus grup. Para poder poner en marcha este proyecto se hizo un análisis profundo de la industria como los consumidores, proveedores, entre otros. Así mismo, se realizaron planes para las diferentes áreas: Estratégico, Operaciones, Marketing, RRHH, Responsabilidad Social, Financiero. Estos planes tienen las estrategias que usaremos para la viabilidad de la empresa. Tuvimos una inversión inicial de S/. 83,451 en el primer año, la utilidad neta del año 1 es de –S/. 58,540, para el segundo año S/. 272,438 y por último en el año 3 S/. 238,315.The present project of a 100% natural infusion based on jamaica leaf, dehydrated pinacapple and cinnamon, which helps women combat the annoying symptoms of menstruation, such as headache, cramps and anxiety. The base of our filter has anticoagulant, antioxidant and relaxation properties. In the present work it will be announced hoy the problem was identified and how we detected the solution, for whom and hoy to approach them. It was found that women have low productivity at work or in studies when they are their menstrual period. Finally, we validete our hypotheses through personal interviews and focus groups. In order to implement this project, an in-depth analysis of the industry was carried out, such as consumers, suppliers, amog others. Likewise, plans were made for the different areas: Strategic, Operations, Marketing, Human Resources, Social Responsability, Financial. These plans have the strategics that we will use for the viability of the company. We had an initial investment of S/. 83,451 in the first year, the net income of year 1 is –S/. 58,540, for the second year S/. 272,438 and finally in the year 3 S/. 238,315.
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Hahn, Robert G. "Clinical pharmacology of infusion fluids." Linköpings universitet, Anestesiologi med intensivvård, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-91319.
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Fluids are used for intravenous infusion during practically all surgeries, but several different compositions are available on the market. Crystalloid fluids comprise lactated or acetated Ringer solutions, normal saline, Plasma-Lyte, hypertonic saline, and glucose. They lack allergic properties but are prone to cause peripheral tissue oedema. Their turn over is governed by physiological factors such as dehydration and drug effects. Colloid fluids include hydroxyethyl starch, albumin, dextran, and gelatin. These fluids have various degrees of allergic properties and do not promote peripheral oedema. Their half-life is usually about hours. Factors increasing the turnover rate are poorly known but might include inflammatory states. Current debates include the widespread use of normal saline, which should be replaced by Ringer’s or Plasma-Lyte in most situations, and the kidney damage associated with the use of starch in septic patients. New studies show that hypertonic saline does not improve survival or neurological damage in prehospital care.
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McQuinn, Dylan Thomas. "Infusion urban and domestic transformation /." Thesis, Montana State University, 2009. http://etd.lib.montana.edu/etd/2009/mcquinn/McQuinnD0509.pdf.
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The turn of the Century in this country brought with it the introduction and ensuing growth of water-born trade markets, facilitating the establishment of a series of metropolitan hubs scattered along the coastline. The subsequent hundred years has seen a major increase in population within these areas accompanied by an economic shift away from maritime trade. Older ports have been abandoned, leaving behind antiquated urban infrastructure. The subsequent dismantling of these vast waterfront industrial areas has provided an opportunity for the reconfiguration of these spaces and the implementation of new urban and landscape strategies. Through a recycling of the existing fabric and introduction of new uses, many cities have revitalized their industrial wastelands and integrated these areas within the existing urban fabric. Other coastal cities have merely overlooked these neglected districts and focused development in their periphery, transforming these former economic focal point into physical and typological barriers.
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Brandley, Mark Wesley. "Void Modeling in Resin Infusion." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5460.
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Resin infusion of composite parts has continually been reaching to achieve laminate quality equal to, or exceeding, the quality produced with prepreg in an autoclave. In order for this to occur, developers must understand the key process variables that go in to producing a laminate with minimal void content. The purpose of this research is to continue efforts in understanding 1) the effect of process conditions on the resultant void content, with a focus on resin infusion flow rate, 2) applying statistical metrics to the formation, location and size of voids formed, and 3) correlate these metrics with the local mechanical properties of the composite laminate. The variation in dispersion and formation of micro-voids and macro-voids varied greatly between the rates of flow the infusion occurred, especially in the non-crimp carbon fiber samples. Higher flow rates led to lower volumes of micro-voids in the beginning section of the carbon fiber laminates with macro-voids being introduced approximately half-way through infusion. This was determined to have occurred decreasing pressure gradient as the flow front moved away from the inlet. This variation in void content per location on the laminate was more evident in the carbon fiber samples than the fiberglass samples. Micro-voids follow void formation modeling especially when coupled with a pressure threshold model. Macro-void formation was also demonstrated to correlate strongly to void formation models when united with void mobility theories and pressure thresholds. There is a quick decrease in mechanical properties after the first 1-2% of voids signaling strength is mostly sensitive to the first 0-2% void content. A slight decrease in SBS was noticed in fiberglass laminates, A-F as v0 increased but not as drastically as represented in the NCF laminates, G and H. The lower clarity in the exponential trend could be due to the lack of samples with v0 greater than 0% but less than 1%. Strength is not well correlated to void content above 2% and could possibly be related to void morphololgy.
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Schmidt, Thorsten. "Infusion, Hüftkopfanbohrung oder Infusion nach Hüftkopfanbohrung in der Behandlung der atraumatischen Hüftkopfnekrose und des Knochenmarködemsyndroms." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1233/.
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Lipsett, Mark Andrew. "Pancreatic plasticity during chronic glucose infusion." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0024/MQ51396.pdf.
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Marsollier-Ferrer, Catherine. "L'amnio-infusion en salle de travail." Montpellier 1, 1997. http://www.theses.fr/1997MON11090.
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Price, William Evan. "Kinetics and equilibria of tea infusion." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/8238.
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Kleine, Astrid, and Emma Stibe. "DropIt : Ett alternativt sätt att ge infusion." Thesis, Halmstad University, School of Business and Engineering (SET), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-5214.
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Thibaudeau, Mikaël. "Towards a fully integrated resin infusion process." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274693.
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Zhang, Siqi. "Functional polymer fibre spinning by infusion gyration." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10052048/.
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Fibres show promising applications such as textiles, filtration, sensing and tissue engineering. In this study, an infusion gyration system to produce polymer micro and nano fibres with functions was introduced. By using this method, functional fibres can be formed from polymer solutions mixed with other functional materials. PEO or PVA water solution was used for making the spinning solutions. The fluorescence protein bound with gold nanoparticles was carried by the PEO water solution, from which the fibres assembled with protein were successfully generated through infusion gyration. A mixed molecular weight PVA combined water solution mixed with processed magnetic nanoparticles achieved fabrication of magnetically controllable fibres have the potential for drug release and its demonstration test showed a positive result. This spinning system provides control of the polymer solution flow rate during spinning which affects the fibre morphology such as average diameter and size distribution. The relationship between the spinning parameters and the product properties was studied for better understanding of the method. The analysis of infusion gyration and its fibre forming process was carried out. The fibres were characterised using several methods, such as optical microscopy, SEM, FTIR and UV-Vis, to establish the potential of infusion gyration and to confirm the functions of final fibre product. The infusion gyration system provides a simple micro and nano scale assembly approach to integrate different protein functionalities into nanofibres with potential applications. Magnetic PVA nanofibres are promising for drug delivery.
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Correia, Nuno André Curado Mateus. "Analysis of the vacuum infusion moulding process." Thesis, University of Nottingham, 2004. http://eprints.nottingham.ac.uk/12762/.
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This thesis focuses on flow through compliant porous media with applications to the manufacturing of composites by vacuum infusion (VI). The context of this work is the need for reliability in environmentally friendly composite processing methods for composite materials. Commercial reality and the prospective application to low cost structures for the transportation industry dictate that appropriate emphasis should be put on obtaining robust simulations, ensuring reliability and progressing toward efficient means of process control. In this context, the open mould manufacturing processes which have been used to produce large composite structures, and are not conducive to quality nor environmental responsibility, must be replaced. Hence, establishing composites as a viable alternative requires closed moulding techniques, of which VI is the most practical for large structures, but where reliability is required for economic survival. This work addresses many aspects of this problem, by making innovative use of fluid mechanics and developing, implementing and proposing new analysis and modelling tools for VI. Main results include a validated analytical model for flow through compliant media, a study of the compliance of textile reinforcements, a finite element model for VI and novel stochastic techniques for the analysis of reliability in liquid composite moulding processes. The work discussed herein stems from a thorough evaluation of published models and leads to novel flow modelling tools for VI including a unique and general formalism for textile compliance. Using these tools it was possible to study, for the first time, the effect of different parameters on VI manufacturing. The reliability issue was addressed by integrating stochastic models for compliance and permeability, and the ability to model complex geometries was demonstrated by adapting a commercial finite element flow code (LIMS).
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Roloff, Nils. "Kontrollierte klinische Studie über die Auswirkungen einer Infusion mit hypertoner Kochsalzlösung auf die Kreislaufsituation bei Kühen mit rechtsseitiger Labmagenverlagerung." Giessen : VVB Laufersweiler, 2007. http://geb.uni-giessen.de/geb/volltexte/2007/4836/index.html.
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Macaulay, Ewan. "Ischaemia-reperfusion during infrainguinal bypass for critical limb ischaemia and the effects of a nitric oxide donor." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301228.
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Hypothesis: That infrainguinal arterial bypass procedures are associated with an ischaemia-reperfusion injury and that this may be reduced by administration of sodium nitroprusside, a nitric oxide donor. First study: 28 subjects, with critical limb ischaemia, undergoing infrainguinal bypass were randomised to receive sodium nitroprusside (0.1 μg/kg body weight/min) (n=15) or placebo (n = 13), infused into the operated limb, during the performance of the second or distal anastomosis and the infusion continued for twenty minutes after. Blood sampling and a doppler studies were performed. 9 patients undergoing varicose vein operations were also examined. The results indicated that application of the proximal clamp resulted in ischaemia and reperfusion with associated neutrophil activation. Sodium nitroprusside resulted in vasodilatation but had no effect on either parameter. Bypass patients had higher baseline neutrophil activation than the varicose vein group. Second Study: 30 further bypass patients ere randomised (treatment n = 15, placebo n = 15) with the infusion commencing at the time of the proximal anastomosis. Blood and urine sampling and doppler studies were performed. Changes in plasma antioxidant status, microalbuminuria and enzymuria occurred only in the placebo group indicating that, in addition to vasodilating the critically ischaemic limb, the nitric oxide donor may have been protective. Paradoxically, myeloperoxidase levels rose only in the treatment group but there was no evidence of increased free radical activity or permeability changes associated with this. Conclusion: Infrainguinal bypass is associated with an ischaemia-reperfusion injury which begins at the time of first clamp application. These procedures also result in a small but significant decrease in antioxidants and an increase in permeability. Sodium nitroprusside, a nitric oxide donor, administered into the operated limb appears to be protective against these changes and is an effective peripheral vasodilator.
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Souza, Sérgio dos Santos. "Efeitos da dexmedetomidina, por via epidural ou infusão contínua intravenosa, em gatas anestesiadas com propofol e isofluorano e submetidas a ovariossalpingohisterectomia." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-06032007-151544/.
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Este estudo determinou e comparou os efeitos da administração epidural ou infusão contínua intravenosa de dexmedetomidina em gatas anestesiadas com propofol e isofluorano para realização de ovariossalpingohisterectomia. Vinte e uma gatas (peso: 3.06±0.35 kg) foram pré-tratadas com dexmedetomidina (4 mcg.kg-1, IM). Quinze minutos depois, administrou-se propofol para permitir entubação orotraqueal seguido de manutenção anestésica com isofluorano diluído em oxigênio por um circuito Mapleson D com respiração espontânea. As gatas foram distribuídas aleatoriamente, em três grupos, onde receberam, por via epidural, lidocaína (1 mg.kg-1, G1, n=7) ou lidocaína (1 mg.kg-1) + dexmedetomidina (4 mcg.kg-1, G2, n=7) ou lidocaína (1 mg.kg-1) + infusão contínua intravenosa de dexmedetomidina (0,25 mcg.kg-1.min-1, G3, n=7). O volume da solução para administração epidural foi ajustada para 0.3 mL.kg-1 com solução salina. A profundidade anestésica foi realizada por um único avaliador que não possuía conhecimento dos fármacos empregados pela via epidural e intravenosa. Foram mensurados freqüência cardíaca (FC) e respiratória (FR), pressão arterial sistólica (PAS) e temperatura retal (TR) antes e quinze minutos após a medicação pré-anestésica. Durante a anestesia, FC, FR, pressões arteriais, concentração expirada de CO2, concentração expirada de isofluorano (ISOe), TR e grau de relaxamento muscular foram avaliados em intervalos de 15 minutos de 20 até 80 minutos. A hemogasometria foi realizada aos 20 e 80 minutos após a indução anestésica. Os valores de FC, FR, TR, escore de analgesia, qualidade e os tempos de recuperação anestésica foram avaliados por três horas após o término da anestesia. Utilizou-se o teste t pareado para avaliar os efeitos do pré-tratamento e os valores hemogasométricos nos dois momentos. O teste análise de variância seguido de Tukey e Friedmann seguido de Dunn foram realizados para variáveis paramétricas e não paramétricas respectivamente (p<0.05). O pré-tratamento com dexmedetomidina reduziu a FC, FR, PAS e TR. A dose de propofol utilizada para indução anestésica foi 7.4±1.4 mg.kg-1. Quando comparado ao G1, a dexmedetomidina, por via epidural, reduziu significativamente a FC dos 20 aos 65 minutos da anestesia e aos 150 e 180 minutos após o término da anestesia, entretanto, por infusão contínua intravenosa reduziu a FC em todos os momentos avaliados da anestesia e recuperação anestésica. Quando comparado ao G2, a infusão contínua intravenosa de dexmedetomidina reduziu a FC aos 60 e 90 minutos da recuperação anestésica. No G1 a média±DP ISOe variou de 0.86±0.28% a 1.91±0.63% de 20 a 80 minutos. Neste período, ISOe foi significativamente menor no G2 (variação de 0.70±0.12% a 0.97±0.20%) e G3 (variação de 0.69±0.12% to 1.17±0.25%). Aos 20 minutos, a PaCO2 foi significativamente superior em G3 em relação ao G1. Os tempos de recuperação anestésica foram significativamente menores no G1, exceto o tempo de extubação se comparado ao G2. Não houve diferença significativa nas outras variáveis entre os três grupos. Conclui-se que o pré-tratamento com dexmedetomidina promoveu depressão cardiorrespiratória. A administração epidural e a infusão contínua intravenosa de dexmedetomidina reduziram o consumo do agente inalatório e produziram recuperação de melhor qualidade e mais prolongada. As administrações de dexmedetomidina causaram bradicardia, porém sem afetar a pressão arterial.This study compared the effects of epidural or continuous intravenous infusion of dexmedetomidine in isoflurane-anesthetized cats undergoing ovariohysterectomy. Twenty-one cats (weight: 3.06±0.35 kg) were premedicated with dexmedetomidine (4 mcg.kg-1, IM). Fifteen minutes later, propofol was titrated to allow endotracheal intubation and anesthesia was maintained in spontaneously breathing cats with isoflurane in oxygen using a Mapleson D system. Cats were randomly allocated to receive either epidural lidocaine (1 mg.kg-1, G1, n=7) or epidural lidocaine (1 mg.kg-1) + dexmedetomidine (4 mcg.kg-1, G2, n=7) or epidural lidocaine (1 mg.kg-1) + continuous intravenous infusion of dexmedetomidine (0,25 mcg.kg-1. min-1, G3, n=7). The volume of either epidural injection was adjusted to 0.3 mL.kg-1 with saline. The individual controlling depth of anesthesia was blinded to the drug being administered epidurally and intravenouslly. Heart (HR) and respiratory (RR) rates, systolic arterial blood pressure (SAP) and rectal temperature (RT) were recorded before and after 15 minutes of premedication. During anesthesia, heart (HR) and respiratory (RR) rates, invasive arterial blood pressures, end-tidal CO2, end-tidal isoflurane (ISOe), RT and muscular relaxation were recorded at 15 minute intervals from 20 until 80 minutes. Arterial blood gases were measured at 20 and 80 min after induction. HR, RR, RT, analgesia score, and recovery quality and times were compared for 3 hours after end of anesthesia. Paired t test were performed to compare the premedication effects and arterial blood gases at differents intervals. ANOVA with Tukey post-test and Friedmann with Dunn post-test were performed to parametric and nonparametric values, respectively (P<0.05). Dexmedetomidine premedication decreased HR, RR, SAP and RT. The induction dose of propofol was 7.4±1.4 mg.kg-1. When compared to the G1, epidural dexmedetomidine significantly decreased HR from 20 to 65 minutes of anesthesia and 150 and 180 minutes after end of anesthesia, however, continuous intravenous infusion decreased HR all times during anesthesia and recovery time. When compared to G2, continuous intravenous infusion of dexmedetomidine decreased HR at 60 and 90 minutes during recovery. In the G1 mean±SD ISOe concentrations ranged form 0.86±0.28% to 1.91±0.63% from 20 to 80 min. At the same time interval, ISOe concentrations were significantly lower in the G2 (ISOe ranged from 0.70±0.12% to 0.97±0.20%) and G3 (ISOe ranged from 0.69±0.12% to 1.17±0.25%). PaCO2 was significantly greater in G3 than G1 at 20 minutes. The recovery times were significantly lower in the G1 except for extubation time when compared with G2. There were no significant differences among groups for the remaining variables. It was concluded that premedication with dexmedetomidine produced cardiorespiratory depression. Epidural administration and continuous intravenous infusion of dexmedetomidine significantly reduced inhalant requirements for maintaining anesthesia and produced a better anesthesia recovery although of longer duration. Dexmedetomidine administration may cause bradycardia, however reduced HR does not affect arterial blood pressure.
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Tohnai, Iwai. "Chemotherapy using Intra-Arterial Infusion for Oral Cancer." Nagoya University School of Medicine, 2006. http://hdl.handle.net/2237/6962.
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Fan, Xiu-Di. "Substantia nigra dopamine infusion, behavioral and biochemical correlates." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ32783.pdf.
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Hoogma, Roeland Petrus Leonardus Maria. "Subcutaneous insulin infusion in type 1 diabetes mellitus." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/29301.
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Gharavi, Hosein. "Infusion of information systems in the stockbroking sector." Connect to thesis, 2006. http://portal.ecu.edu.au/adt-public/adt-ECU2006.0016.html.
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Shafik, I. M. "Effects of magnesium infusion on renal calcium excretion." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379137.
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Hoagland, David Wayne. "Continuous Permeability Measurement During Unidirectional Vacuum Infusion Processing." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6457.
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Composite materials have traditionally been used in high-end aerospace parts and low-end consumer parts. The reason for this separation in markets is the wide gap in technology between pre-preg materials processed in an autoclave and chop strand fiberglass blown into an open mold. Liquid composite molding has emerged as a bridge between inexpensive tooling and large, technical parts. Processes such as vacuum infusion have made it possible to utilize complex layups of reinforcement materials in an open mold style set-up, creating optimal conditions for composites to penetrate many new markets with rapid innovation. Flow simulation for liquid composite molding is often performed to assist in process optimization, and requires the permeability of the reinforcement to be characterized. For infusion under a flexible membrane, such as vacuum infusion, or for simulation of a part with non-uniform thickness, one must test the permeability at various levels of compaction. This process is time consuming and often relies on interpolation or extrapolation around a few experimental permeability measurements. To accelerate the process of permeability characterization, a small number of methodologies have been previously presented in the literature, in which the permeability may be tested at multiple fiber volume contents in a single test. Some of the methods even measure the permeability over a continuous range of thicknesses, thus requiring no later interpolation of permeability values. A novel method is presented here for the rapid measurement of permeability over a continuous range of fiber volume content, in a single unidirectional vacuum infusion flow experiment. The thickness gradient across the vacuum bag, as well as the fluid pressure at several locations in the mold, were concurrently measured to calculate the fabric compressibility. An analytical flow model, which accounts for the compressibility, is then used by iterating the fitting constant in a permeability model until the predicted flow front progression matches empirical measurement. The method is demonstrated here for two reinforcement materials: 1) a fiberglass unbalanced weave and 2) a carbon bi-ax non-crimped fabric. The standard deviation of calculated permeabilities across the multiple infusion experiments for each material and flow orientation ranged from 12.8% to 29.7%. Validation of these results was performed by comparing the resulting permeability with multiple non-continuous permeability measurement methods.
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Murphy, Robert S. "The design of safety-critical medical infusion devices." Thesis, University of South Wales, 2007. https://pure.southwales.ac.uk/en/studentthesis/the-design-of-safetycritical-medical-infusion-devices(1557c702-3087-43f9-a399-99a9ba65ae9b).html.
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Intravenous infusion devices - commonly known as infusion pumps - provide clinicians with mechanisms to automate the accurate dosing of potent fluid therapies to critically ill patients. In critical care applications, fluid dosing must be both accurate and safe since unwanted flow disturbance can cause physiological harm to the patient. This study consists of three discrete projects based on these vital themes of safe device design and accurate fluid delivery. The first project, commissioned by Medical Magnetics Ltd during the period 1998 onwards, proposed that the fail-safe design philosophy universally used in the design of infusion pumps, and implemented in embedded software, is lengthy and provides the manufacturer with difficulties in demonstrating the exhaustive fail-safe validation needed for an instrument to be released speedily for sale. An alternative and innovative strategy employing the design of hardware modules and using re-configurable VLSI, is proposed and shown to offer a significant reduction of the design and validation phase of development with consequent financial benefit to the manufacturer. The second project conducted as part of the Manukau Institute Research Programme for 2003 examined the manner in which dosing accuracy is assessed for infusion pumps. The International Standard used by clinicians to select apparatus suitable for treatment of 'critically-ill' patients is shown to be flawed and potentially misleading - a finding of international significance. An innovative mathematical simulation model is described that enables prediction of flow accuracy for various expected operating scenarios previously impossible to investigate using current laboratory measurement techniques. Use of this simulation model indicates that various mechanical design factors influencing system compliance and hence dosing accuracy have been previously ignored by designers and suggests that contemporary infusion pump designs are far from optimum. These findings offer an explanation for instances of dosing error previously reported in the clinical literature and are of international value. The third project of the study utilises the findings of, and is subsequent to, the second project. An innovative design is proposed for an infusion therapy device in which dosing accuracy may be maintained under operating conditions such as height change and patient venous pressure variation that cause unwanted errors in conventional equipment designs. This design is the subject of patent application, commercial exploitation and further development.
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Thompson, Joseph E. "Compaction and Cure of Resin Film Infusion Prepregs." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/36479.
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Gutowski et al.'s model has been employed to describe the cure and consolidation of prepregs used for resin film infusion. Resin kinetics, rheology, flow and fiber deformation are considered. Resin kinetics are simulated with an isothermal autocatalytic-1 type relation. The non-Newtonian viscosity of the Cytec™ 754 resin is represented with a gel type expression. The one dimensional flow of resin through a deformable, partially saturated porous medium is studied. A nonlinear partial differential equation describing the spatial and temporal variation of the fiber volume fraction combining the continuity equation, Darcy's Law, and mat compressibility has been derived and solved numerically. Resin is assumed to be incompressible and inertial effects are neglected. Based on the resin content of regions where resin and fiber coexist, expressions for tracking resin flow through fully and partially saturated regions of fiber are given. Values of material parameters for the E-QX 3600-5 glass fabric are estimated from literature data involving compression of similar dry fabrics and through comparison of computed results with the experimental data. Results for the final thickness of the consolidated part agree with the experimental values, but those for the mass loss do not.Master of Science
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Waschburger, Diane Jaqueline. "Parâmetros Cardiorrespiratórios e Hematológicos em Cães Anestesiados com Isofluorano e Tramadol, Pré-medicados com Clonidina." Universidade Federal do Pampa, 2014. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/185.
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Com o presente estudo, propôs-se avaliar os efeitos da clonidina como medicação pré-anestésica, sobre parâmetros cardiorrespiratórios e hematimétricos em cães anestesiados com isoflurano, associada à infusão contínua de tramadol. Para isso, foram utilizados 8 cães sem raça definida, adultos, hígidos, com peso médio de 15,3 ± 3,7 kg, oriundos do canil da Universidade Federal do Pampa mediante doação. Cada animal foi anestesiado em duas ocasiões, com intervalo mínimo de um mês. Os animais foram distribuídos em dois grupos aleatórios: grupo Clonidina (GCL; pré-medicados com clonidina, 5 μg/kg) e grupo Controle (GC; pré-medicados com solução salina). Passados 15 minutos da MPA, os animais foram induzidos à anestesia geral pela administração de propofol 8mg/kg e mantidos com isoflurano à 1 CAM. Após período de estabilização, foi realizada a aplicação do bolus de tramadol (2 mg/kg) seguido pela infusão contínua do mesmo (1,5 mg/kg/h). Foram mensurados temperatura (oC), frequência cardíaca (FC), frequência respiratória (f), eletrocardiografia, pressões arteriais sistólica, diastólica e média (PAS/PAD/PAM), pressão parcial de dióxido de carbono ao final da expiração (EtCO 2 ), saturação de oxigênio (SpO2), hemograma, leucograma, glicemia, e lactacemia, dose de indução, tempo de extubação e qualidade da recuperação anestésica. As mensurações foram realizadas nos seguintes períodos: antes da MPA, antes da indução, antes do bolus de tramadol e após início das infusões, a cada 10 minutos até se completarem 60 minutos das mesmas. Os parâmetros hematológicos, glicemia e lactacemia foram mensurados nas amostras de sangue coletadas antes da aplicação da medicação pré-anestésica, antes da indução, antes do bolus do tramadol e aos 30 e 60 minutos após início das infusões. A avaliação estatística dos resultados foi realizada utilizando-se teste de ANOVA seguido pelo teste de Tukey (p<0,05). Houve diferenças na frequência cardíaca e nas demais variáveis as diferenças não foram significativas ao longo do período experimental. A associação demonstrou-se segura em animais hígidos, sendo necessário mais estudos quanto à doses, vias de aplicação e antinocicepção na espécie.
With this study, the effects of premedication with clonidine over cardiorespiratory and hematimetry in dogs anesthetized with isoflurane and receiving continuous infusion of tramadol, were evaluated. Eight crossbreeding healthy adult dogs, weighting 15,3±3,7kg, provided from Federal University of Pampa kennel, were used. Animals were randomly anesthetized twice with a month interval and allocated in two groups (n=8), Clonidine (CLG) and Control (CG). Animals in CLG received a 5 μg kg -1 bolus of Clonidine diluted in 1mL as premed, while animals in CG received an injection of 1 mL of saline. Anesthesia was acquired with propofol 8 mg kg -1 and maintained with isoflurane (1MAC). After a stabilization period, animals received a bolus of tramadol (2 mg kg -1 ) followed by a continuous rate infusion of 1.5 mg kg -1 h of the same drug. Parameters evaluated were: body temperature (oC), heart rate (HR), respiratory frequency (f), electrocardiography, systolic, diastolic and median arterial blood pressure (SAP, DAP and MAP, respectively), end-tidal carbon dioxide (EtCO 2 ), hemoglobin saturation (SpO 2 ), hematimetric, leucocitary, glucose, lactate, propofol consumption, time of extubation and recovery quality. Data were collected before premed, before induction, before tramadol bolus, and each 10 minutes after CRI was initiated, until a 60 minutes period was achieved. Blood samples were performed before premed, before induction, before tramadol bolus and 30 and 60 minutes after CRI was initiated. Data were evaluated with ANOVA followed by Tukey`s test (p<0.05). It was observed a significant decrease in HR, while other variables showed no differences throughout the experimental period. It was concluded that the association has been shown to be safe for use in healthy animals. Further studies are necessary to determinate if this drug could enhance antinociceptive effect of tramadol in dogs.
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Thuresson, Jenny, and Mathilda Davidsson. "Moneo: Säkert varningssystem för detektering vid infiltration." Thesis, Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-15255.
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I Sverige drabbas varje år mer än 150 barn av allvarliga skador under infusionsbehandling. I nära samarbete med Hallands sjukhus Halmstad och har ett varningssystem utvecklats för att detektera infiltration under infusionsbehandling. Detta är en produkt som efterfrågats i 30 år av barnläkaren och idéskaparen till projektet, Kent-Åke Henricson. Infiltration är en medicinsk term som beskriver när infusionsvätska läcker ut i omgivande vävnad runt blodvenen. Beroende på vilket läkemedel som infiltrerats kan skadans allvarlighetsgrad variera från en lätt hudreaktion till allvarlig nekros. Vid en allvarlig infiltration förlängs vårdtiden vilket blir kostsamt för sjukhusen. Moneo underlättar arbetet för sjukvårdspersonal likaså ger det barn en trygg och säker behandling. Idag görs rutinkontroller av sjuksköterska upp till varannan timme på droppets insticksställe, vilket är både tidskrävande och störande för patienten. Produkten fungerar som ett kompletterande stöd vid behandling och är anpassad för att användas med befintlig infusionsutrustning. Barn är aktiva patienter och produkten är utformad för att tillåta fysiska rörelser och genom sin lätta vikt och smarta konstruktion är produkten bekväm för patienten och enkel att integrera i sjukvårdspersonalens rutiner. Projektgruppen är stolt och nöjd över att presentera sitt examensarbete Moneo, som resulterat i en produkt som ger säkrare vård och förhindrar onödigt lidande för barn. Ingen patient ska behöva skadas i vården, det är en grundprincip för all vårdverksamhet.Each year more than 150 children suffer from severe injuries during IV infusion therapy in Sweden. In close cooperation with Hallands sjukhus Halmstad, a new warning system has been developed for detection of infiltration during IV infusion. For more than 30 years this kind of product has been requested from pediatrician and innovator Kent- Åke Henricson. Infiltration is a medical term used to describe when you infuse medical drugs into the surrounding tissue instead of into the vein. Depending on the type of medicine that has been infiltrated, the severity of the injury varies from light skin reaction to severe necrosis. A severe infiltration leads to extended hospital stays for the patient, which can be costly for the hospital. Today a nurse does regular checkups every two hours at the puncture site in order to insure that the medicine is being delivered properly. This is very time consuming for medical staff, as well as, annoying for the patient. Our product will function as an additional safe guard during infusion therapy and is adapted to be used with existing infusion devices. Moneo allows for easier monitoring by medical staff while giving children a more safe treatment. Children are active patients and Moneo’s light weight and smart design allows for physical movement and comfort of the patient. It is also easily integrated into the existing procedures and routines of the medical professionals. The project group is proud and happy to present their final thesis, Moneo, which has resulted in a product that can eliminate unnecessary suffering in the children receiving IV infusion therapy thereby providing a more safe treatment option. It is a basic medical principle that no patient should suffer negative side effects of a medical procedure. Moneo can be used to avoid these kinds of concerns.
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Ackerman, Henrieta. "Improving thinking abilities by creating a culture of a thinking classroom during science and technology lessons for pupils of the 11-12 years old age group." Thesis, Anglia Ruskin University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248883.
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Channer, Kevin John. "Experimental investigation into the double RIFT diaphragm forming process." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246819.
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Kenerson, Jonathan E. "Quality Assurance and Quality Control Methods for Resin Infusion." Fogler Library, University of Maine, 2010. http://www.library.umaine.edu/theses/pdf/KenersonJE2010.pdf.
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Mallen, Cheryl Ann. "Rethinking pedagogy for the times: a change infusion pedagogy." University of Southern Queensland, Faculty of Education, 2006. http://eprints.usq.edu.au/archive/00004789/.
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[Abstract]: This doctoral dissertation research reports on the exploration of higher education academics’ pedagogical responses to complex societal postindustrialchange. The topic arises from a deep personal interest in processes of societal change and the need for such processes to be in the professional practices ofacademics. The research problem that guides the study is: In what way(s) and to what extent can University instructors be assisted to incorporate change-basedconcepts in their pedagogical practices through application of a conceptual framework for change infusion?In response to the problem, a change infusion model (CIM) arises from an analysis of authoritative literature on change. Change infusion is an educational process that utilises key concepts from theories of change to provide ameaningful context for pedagogical practice in times where pervasive societal transformation is the norm. Gay’s (1995) multiple stages of infusion are of particular importance in the CIM. The generation of the theoretical definition of infusion in the CIM provides practising academics with an explanatory system that enables them to infuse significant elements of change into pedagogicalpractices. In essence, the CIM purports to guide instructors to move beyond teaching about change to teaching for change.The research design includes the cognitive-constructivist theoretical foundations, with particular reference to Dewey (1933), Piaget (1951), Lewin (1951), Schön (1983, 1987), Calderhead (1988), and Patton (2002). Ofparticular importance is the analysis of opinions concerning pedagogical practice of a small number of University practitioners after engaging with theCIM during each of the three stages of trials. The trials utilize the cognitiveconstructivist quality of reflection as a means to link theory to practice.The conclusions from the research support a conceptual model, such as the CIM, for use to teach for change. As a result of the Stage 3 trial research in particular, the conceptual model from the beginning point of the study isrefined, thereby hopefully providing a useful tool for academics in a wide range of contexts and disciplines to respond in meaningful ways to the process ofmajor change that impinge upon them and their work.
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DuQuesnay, Renée. "Infusion of oligonucleotides into the brain produces behavioral effects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ36433.pdf.
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Sjöstrand, Fredrik. "Volume kinetics of glucose solutions given by intravenous infusion /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-235-7/.
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Avison, Shane J. "Supercritical infusion of flavour into synthetic- and bio- polymers." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250532.
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Goran, M. I. "Metabolic responses to chronic endotoxin infusion in the rat." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376584.
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Love, Christopher K. "Investigation of RF Curing Parameters in Resin Infusion Molding." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2074.
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The purpose of this study is to investigate RF or Radio Frequency energy as a viable alternative to traditional heating methods for the purpose of curing resins used in resin infusion molding, a molding system for polymeric composites. Traditional heating/curing methods include technologies such as room temperature, oven, microwave, infrared, and ultraviolet. Although RF curing provides far more advantages than disadvantages, its implementation into a manufacturing process can be challenging. Specifically, three critical elements must be present in order for RF to function in a manner that is profitable to the manufacturer. Those elements are: (1) the proper generator (voltage and frequency), (2) the correct electrode configuration, and (3) the appropriate material sensitizer (amount and type). There is also the consideration of initial capital investment; which is by no means insignificant. However, if all 3 elements are present, the benefits can be immediate and numerous. Potential advantages include the following: improved part quality through penetrating and uniform heating; competitive, if not superior, material physical properties; and drastically reduced curing times. Other potential advantages include floor space savings, high energy efficiency, and increased operational flexibility. For the purpose of this thesis, experimentation will be conducted to first confirm and then, if successful, quantitatively capture the reduction in curing time. Physical properties will also be measured using tensile testing to determine whether or not RF curing can facilitate minimal loses in the material's physical properties.
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Adams, C. B., D. S. Street, and John B. Bossaer. "Incidence of Cetuximab-related Infusion Reactions in Northeastern Tennessee." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/2351.
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Adams, C. B., D. S. Street, and John B. Bossaer. "Incidence of Cetuximab-related Infusion Reactions in Northeastern Tennessee." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/2352.
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Danielsson, Sebastian. "Physiological characteristics of sodium lactate infusion during resistance exercise." Thesis, Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-5782.
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Previous studies that utilized sodium lactate infusion did not use resistance exercise protocol or analyzed muscle biopsies, or performed sex specific analysis. Aim: We initiated a project where resistance exercise was performed with low and high levels of lactate, acquired by venous lactate infusion where the specific aim of this study was to investigate and chart the physiological characteristics of sodium lactate infusion during a bout of resistance exercise on whole group level and sexes separated Method: A randomized, placebo controlled, cross-over design was implemented where male (n = 8) and female (n = 8) subjects accustomed to resistance exercise visited the laboratory three times for preliminary testing and training familiarization. In the following two experimental trials subjects arrived in an overnight fasted state. A resting state muscle biopsy was extracted from m. vastus lateralis and repeated blood samples were initiated which followed by 20 minute of baseline infusion of either infusate in resting state at 0.05 mmol/kg/min infusion rate with additional bolus doses during subsequent exercise. Following a brief warm up, unilateral knee-extensions (6 x 8-10 reps at 75% of 1-RM) were performered with or without venous infusion of sodium lactate, with volume matched saline as control. Exercise load and volume were matched between trials. Four additional biopsies were extracted at post-exercise, recovery period, and 24-hour post-exercise. Results: Sodium lactate infusion vs saline infusion respectively during resistance exercise yielded significantly higher blood lactate with sodium lactate (6.78 ± 0.33 mmol/l vs 2.99 ± 0.17 mmol/l), plasma lactate (8.86 ± 0.39 mmol/l vs 4.39 ± 0.22 mmol/l), blood sodium (143 ± 0.4 mmol/l vs 142 ± 0.3 mmol/l), blood pH (7.42 ± 0.01 vs 7.34 ± 0.01), but lower blood potassium (3.9 ± 0.1 mmol/l vs 4.2 ± 0.1 mmol/l), all immediately following exercise. Sodium lactate infusion elicited main effect of trials and muscle lactate increased from baseline (8.5 ± 0.9 mmol·kg-1 dw vs 7.0 ± 0.6 mmol·kg-1 dw) to post-exercise (31.5 ± 2.8 mmol·kg-1 dw vs 26.9 ± 3.2 mmol·kg-1 dw) with sodium lactate and saline infusion respectively. Blood glucose, hemoglobin and muscle pH was not affected by sodium lactate infusion. Conclusions: Utilization of the sodium lactate infusion method during a bout of resistance exercise may be used as tool to effectively increase blood/plasma lactate and, to lesser extent, muscle content of lactate. However, a concomitant slightly alkalizing effect of blood likely will occur.Tidigare studier som använt natriumlaktat infusion använde inte styrketräningsprotokoll, eller analyserade muskelbiopsier eller utförde könsspecifika analyser. Syfte och frågeställningar: Vi initierade ett projekt där styrketräning utfördes med låga eller höga nivåer av laktat som erhölls genom venös natriumlaktat infusion med det specifika syftet att undersöka och kartlägga fysiologisk karakteristiska av naturiumlaktat infusion under styrketräningsövning på helgrupps- och könsseparerad nivå. Följande frågeställningar inrättades; hur påverkar natriumlaktat infusion under styrketräning helblod- och plasma laktat, glukos, natrium, kalium, plasma volym genom hemoglobin och hematokrit, blod pH, muskellaktat- och muskel pH samt om skillnader i respons finns efter att könsspecifika analyser utförts på dessa variabler. Metod: En randomiserad, placebokontrollerad cross-over design implementerades där styrketräningsvana män (n = 8) och kvinnor (n = 8) besökte laboratoriet tre gånger för preliminäraför tester och träningsfamiliarisering. I efterföljande två experimentella försök anlände försökspersonerna i ett över nattligt fastande tillstånd. En baslinje biopsi extraherades från m. vastus lateralis och repeterade blodprover initierades med efterföljande 20 minuter av baslinje infusion av endera infusat i vilotillstånd med 0.05 mmol/kg/min infusionshastighet med ytterligare bolusdoser under efterföljande träning. Efter en kort uppvärmning utfördes unilaterala knäextensioner (6 x 8-10 reps vid 75% av 1-RM) med eller utan venös infusion av natrium laktat, med volymmatchande saltlösning som kontroll. Träningsbelastning och volym matchades mellan försök. Ytterligare fyra biopsier extraherades vid efter-träning, återhämtningsperiod, och efter 24 timmar. Resultat: Natriumlaktat respektive saltlösnings infusion under styrketräning gav signifikant högre blodlaktat med natriumlaktat infusion (6.78 ± 0.33 mmol/l mot 2.99 ± 0.17 mmol/l), plasmalaktat (8.86 ± 0.39 mmol/l mot 4.39 ± 0.22 mmol/l), blodnatrium (143 ± 0.4 mmol/l mot 142 ± 0.3 mmol/l), blod pH (7.42 ± 0.01 mot 7.34 ± 0.01), men lägre blod kalium (3.9 ± 0.1 mmol/l mot 4.2 ± 0.1 mmol/l), alla direkt efter träning. Natriumlaktat infusion framkallade huvudeffekt av försök och muskellaktat ökade från baslinje (8.5 ± 0.9 mmol·kg-1 dw mot 7.0 ± 0.6 mmol·kg-1 dw) till efter-träning (31.5 ± 2.8 mmol·kg-1 dw mot 26.9 ± 3.2 mmol·kg-1 dw) med natriumlaktat respektive saltlösnings infusion. Blodglukos, hemoglobin och muskel pH påverkades inte av natriumlaktat infusion. Slutsats: Användande av natriumlaktat infusion som metod under styrketräning kan effektivt användas som verktyg för att höja blod/plasma laktat, och i mindre utsträckning, muskellaktat. Emellertid är samtidig alkalisering av blod en sannolik följd.
Potential sex differences in the molecular response to resistance exercise with lactate infusion
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Peña, Kristen Helen. "Characterization of an oxygen suspension used for intravenous infusion." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/75714.
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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 45).
Oxygenated fluid mixture can be used to treat critically ill patients suffering from asphyxia, lung injury, and cardiac arrest. This oxygenated fluid delivered intravenously re-oxygenates the bloodstream, allowing for more time to resuscitate a patient before they suffer brain and/or organ damage. The concentration of the mixture is crucial for treatment as it affects the viscosity of the fluid, which in turn affects how well the fluid mixes with blood and how long it takes for oxygen to diffuse out of it. Evaluating the quality of fluid delivered and characterizing oxygenated fluid mixture at different concentrations was paramount. Since the fluid is a non-Newtonian emulsion, delivering a specific flow rate is challenging due to the following effects: degradation, compressibility, and shear thinning. Therefore, a testing machine was developed to aid in understanding the fluid dynamic behavior of the oxygenated mixture. The quality of the fluid can be assessed through measurement of the volume percentage, particle size distribution, oxygen tension, and rheometry. The data collected from the experiments will serve to create a model for delivering a specific volumetric flow rate of the fluid at atmospheric pressure.
by Kristen Helen Peña.
S.B.
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O'Keefe, Zachary Scott. "Infusion: catalyzing progressive design strategies in the Knobtown District." Kansas State University, 2012. http://hdl.handle.net/2097/13688.
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Master of Landscape ArchitectureDepartment of Landscape Architecture/Regional and Community Planning
Blake Belanger
Sustainable landscape design is generally understood in relation to three principles—ecological health, social justice, and economic prosperity. However, people have neglected to recognize the significance of their impact on the environment. The real conflict begins to address our relationship with the environment and how we attempt to reconnect and reverse centuries of environmental degradation. As a society, we lie at the intersection of the past and the future, presenting us the opportunity to think organically. Harboring values much different from post-industrial thinking, organic values work with nature rather than against it. However, most contemporary processes are not organic in nature. Rather they are products of our isolated way of thinking; a limited form of consciousness that arrogantly declares that we are the greatest intelligence on Earth. This consciousness has taught us that for our survival, it is our duty to subdue nature, relating to it as a resource for implementing how and what our minds invent. We have learned to relate to nature as a commodity rather than respect it as our community. Infusion seeks to establish this connection by creating a Transit-Oriented Development in the Knobtown District that uses the power of aesthetics to promote and inspire educational exploration, cultural expression, and ethical revelation of sustainable design. Supporting this solution is a four-part foundational framework that identifies specific design principles that are envisioned to improve the way we relate to our environment through aesthetic eminence educational exploration, cultural expression and ethical revelation. The conceptualized framework is structured to be adaptable for many design situations becoming a foundation for the way in which we design and interact with form and space. In its final state, Infusion communicates the significance of these essential design principles and how the new Knobtown District can become an important part of the Rock Island Corridor.
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Lindemalm, Josefin, and Anna Akkawi. "The New Infusion Pump System at New Karolinska Solna." Thesis, KTH, Medicinsk teknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210183.
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In November 2016 a brand new and highly technological hospital called New Karolinska Solna opened in Stockholm. In connection with the planning of the hospital, new medical devices were procured, including a new infusion system that is now in use. Previously, each ward at the hospital had their own pumps and was responsible for updates and maintenance. Now, the hospital will instead have a floating pump system, which means that the hospital will own the pumps. The infusion pumps will be floating between the wards without being linked to a specific ward or department. The updates that were previously done when the need arose at the ward will now be a common process for the entire hospital. The aim of the project was to develop new guidelines for how the update process should be done on New Karolinska Solna's new infusion pump system. Through interviews with key personnel during the procurement process, the medical technicians department and caseworkers, new guidelines have been written, given the already existing technical conditions. During the course of the project it has been found that there are major shortcomings of information and communication within the hospital. The guidelines presented in the result are an important part to ensure that information related to the update comes to the caregivers at New Karolinska Solna, thus simplifying and streamlining the update of the infusion pumps.
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Reid, Peter Geddes. "Cardiovascular and respiratory effects of adenosine infusion in man." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/27252.
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Three studies were performed in patients undergoing diagnostic cardiac catheterisation. In one study infusion of adenosine into the aorta proximal to the head and neck vessels caused respiratory stimulation whereas infusion into the upper descending thoracic aorta did not, although chest and epigastric discomfort were more common. Since in animals adenosine depresses respiration within the central nervous system, this study supports the suggestion that adenosine may stimulate respiration by an action within the carotid bodies. Furthermore it suggests that the respiratory stimulation is not primarily due to symptoms caused by adenosine. In a second study the mean plasma adenosine concentration in the upper descending thoracic aorta increased from 0.07 μM at baseline to 1.2 μM during iv infusion at the maximum dose. Since micromolar concentrations may be achieved in tissues during hypoxia, due to hydrolysis of adenine nucleotides, these results are consistent with the suggestion that adenosine might participate in the ventilatory response to hypoxia. An unexpected finding was that respiration increased in 3 of the 7 patients before the adenosine concentration did. Since adenosine has a half-life of only a few seconds this finding is consistent with a more proximal effect of adenosine, e.g. within the lungs. In a third study, which investigated its haemodynamic effects, adenosine increased cardiac output and caused pulmonary and systemic vasodilation. The pulmonary vasodilation first developed at a dose which did not affect systemic vascular resistance suggesting that at low dose (≤ 60 μg/kg/min) adenosine might be useful as a selective pulmonary vasodilator. Higher doses produced an increase in left ventricular end-diastolic pressure of uncertain cause. Adenosine caused variable effects in 6 patients with chronic hypoxia due to obstructive airways disease. Four showed a slight increase in minute ventilation and improvement in arterial blood gas tensions. None developed worse spirometry but all showed an increase in FRC which was greatest in 2 patients whose tidal volume and arterial oxygen tension fell, suggesting that the changes in lung volume were disadvantageous.
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Linderoth, Henrik. "Från vision till integration : infusion av telemedicin : en översättningsprocess." Doctoral thesis, Umeå universitet, Handelshögskolan vid Umeå universitet (USBE), 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66623.
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During the 1990's high expectations were put on telemedicine technology in health care organizations, which can be seen as a reflexion of the society's interest in IT. The use of tele-medicine is expected to improve the quality and decrease costs of health care services. However, if these expectations are to be attained the visions have to be translated into fields of application in local settings where the technology would be used. This could be seen as an infusion process, which means that the technology would incrementally be used in a comprehensive and integrated manner. In this thesis, four Swedish telemedicine projects are analyzed. The approach used is that of Actor network theory (ANT), which has enabled the development of a theory of the infusion process, implementation of IT-projects, and parts of ANT, e.g. the model of the translation process and the notion of inscription. By using the concept of translation, it is possible to see the infusion process as a process where the generic features of the technology (transmitting sound and pictures in real time) are translated into concrete activities in local settings. These fields of application are realized by the mobilization of different task-based networks, where the roles of the actors are defined by the task to be solved. An iterated mobilization of the network implies further that the network will become stabilized, which is a central dimension in the process of infusion. Another way to understand the process of infusion is to describe it as cycles of implementation, where one cycle symbolizes the implementation of a field of application, which is a result of the translation of the generic features of the technology. The inscriptions in the studied technology allow a high degree of flexibility of use and flexibility of action. The flexibility means that fields of application ought to be developed in interaction between actors in local settings, and supporting programs of action are to be identified, or developed, in order to integrate technology use into daily routines. The considerable numbers of failed of IT-project implementations can be explained by the fact that a traditional planning perspective has been used on technologies, which allow a high degree of flexibility of use and flexibility of action. However, by categorizing inscriptions in technological artifacts, it becomes possible to predict what kinds of implementation strategies are appropriate for different kinds of technologies. By viewing the implementation of open networking technologies as a process of translation, the infusion process will be facilitated and a comprehensive and integrated use of technology will be enabled.digitalisering@umu
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Batiston, Michele Cristina. "O uso da bomba de infusão inteligente em pacientes hospitalizados." Botucatu, 2018. http://hdl.handle.net/11449/154826.
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Orientador: Silvana Andrea Molina LimaResumo: O objetivo deste trabalho foi avaliar a evidência científica disponível sobre o uso das bombas de infusão inteligentes em pacientes hospitalizados. Foi realizado um estudo, de acordo com Diretrizes Metodológicas propostas pelo Ministério da Saúde para a elaboração de pareceres técnico-científicos (PTC). Foi realizada uma busca até 14 de novembro de 2017 nas bases de dados The Cochrane Library, EMBASE, PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e de Avaliações de Tecnologias de Saúde (ATS), não houve restrição de idioma e ano de publicação do artigo. Os resultados das bases de dados foram agrupados e eliminados os estudos em duplicatas. Em seguida, aplicados os critérios de elegibilidade para os títulos e resumos, restando 51 estudos para leitura completa. Após leitura dos artigos na íntegra, foram selecionados 6 estudos, que incluíram revisão sistemática sem metanálise, três estudos observacionais sem comparador e dois estudos observacionais do tipo antes e depois. Os estudos não apresentaram dados conclusivos para redução do número de eventos ocorridos. Para a interceptação de erros/prevenção de erros, os estudos demonstraram que a bomba inteligente interceptou e impediu diversos erros como frequência, dose e programação erradas. Para os custos, o estudo de revisão sistemática sem metanálise inclui um estudo que apresentou redução de custos da Bomba de Infusão Inteligente pelos possíveis eventos adversos evitáveis. A recomendação é incerta,... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Title: Intelligent Infusion Pump versus Conventional Infusion Pump: Comparison of cost and safety. Recommendation for the use of technology: ( ) In favor of (X) Uncertain ( ) Against Brief justification for the recommendation: Studies with little scientific evidence, the costs with the materials, the need to qualify, the construction of a library, among other strategies. Population: Patients hospitalized Technology: Intelligent Infusion Pumps Comparator: Conventional Infusion Pumps Search and analysis of scientific evidence: A search was performed to 2017, November 14 in the databases The Cochrane Library, EMBASE, PubMed and Latin American, Caribbean Literature in Health Sciences (LILACS) and the Health Technology Assessment (ATS). There was no language restriction and year of publication of the article. The results of the databases were grouped and the duplicate studies were eliminated. Then, the eligibility criteria for titles and abstracts were applied, leaving 51 studies for complete reading. After reading the articles in full, 06 studies were selected. Summary of results of selected studies: Six studies were included: one systematic review without meta-analysis, three observational studies without comparator, and two before-after observational studies. The studies did not present conclusive data to reduce the number of events that occurred. For error interception / error prevention, studies have shown that the smart pump intercepted and prevented various errors such as f... (Complete abstract click electronic access below)
Mestre
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Souto, Maria Teresa de Mello Rêgo. "Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27022012-110748/.
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Os equinos são comumente anestesiados com agentes voláteis em procedimentos cirúrgicos acima de 60 minutos, resultando em depressão cardiovascular dosedependente, contribuindo para uma alta taxa de mortalidade. Sendo assim, este estudo objetivou determinar se o fentanil, em infusão contínua, seria capaz de diminuir a fração expirada de isoflurano, promovendo estabilidade cardiovascular transoperatória e uma melhor recuperação após cirurgia de artroscopia, em comparação à infusão de lidocaína ou quetamina, durante a manutenção da anestesia com isoflurano. Para tanto foram utilizados 20 equinos de 3 a 8 anos e pesando 350 a 500kg, submetidos a cirurgia de artroscopia em decúbito dorsal. Os animais foram divididos aleatoriamente em 4 grupos: GL (1,5 mg/kg em bolus e infusão de 0,15mg/kg/min) ; GQ (2mg/kg em bolus e infusão de 0,2mg/kg/min); GF (7µg/kg em bolus e infusão de 0,7µg/kg/min) e GI que não recebeu infusão de nenhum fármaco adjuvante. Foram avaliados os parâmetros cardiovasculares (FC, PAM, PAS e PAD), ventilatórios e de oxigenação (PaO2, PaCO2, Compl e Rva), fração expirada de isoflurano [ISSO](Fexp%), e qualidade de recuperação. Em relação à [ISSO] (Fexp%) as maiores quedas foram observadas no momento 30bolus em todos os grupos, que utilizaram adjuvantes, comparados ao momento basal sendo, GL (1,50 para 0,90%) GQ (1,44 para 0,96%) e GF (1,32 para 0,96%). Observou-se que após 15 minutos da interrupção da infusão contínua de fentanil e lidocaína a fração expirada de isoflurano foi aumentada GL 25% e GF 45%. Apesar de não ter havido diferença estatística, o GF apresentou escore de recuperação menor 16,8 pontos, GL 24,6; GQ 30,0 e GI 31,8 pontos. Conclui-se então que o uso do fentanil foi capaz de reduzir a fração expirada de isoflurano em até 43%, não observando qualquer efeito colateral no momento da recuperação após re-sedação com xilazina 0,5mg/kg.Volatile anesthetics are commonly used in horse anesthesia in surgical procedures over 60 minutes, resulting in a dose-dependent cardiovascular depression, contributing to a high mortality rate. Thus, the aimed this study was determine whether fentanyl continuous rate infusion would be able to reduce end tidal isoflurane, promoting intraoperative cardiovascular stability and a better recovery after arthroscopic surgery, when compared to lidocaine or ketamine infusion during maintenance of anesthesia with isoflurane. Therefore, 20 horses aging 3-8 years and weighing 350 to 500 kg underwent arthroscopic surgery in dorsal recumbence. The animals were randomly divided into four groups: GL (1.5 mg/kg bolus and 0.15 mg/kg/min infusion rate of lidocaine), GQ (2 mg/kg bolus and 0.2 mg/kg/min infusion of ketamine); GF (7µg/kg bolus and 0.7 mg/kg/min infusion rate of fentanyl) and GI did not receive any adjuvant infusion. Cardiovascular parameters (HR, MBP, SBP and DBP), ventilatory and oxygenation (PaO2, PaCO2, Cst and Rva), end tidal isoflurano [ISO] (Fexp%), and quality of recovery were evaluated. Regarding [ISO] (Fexp%) the highest decreases were observed at the time 30bolus in all groups with adjuvants, in comparison to base line -GL (1.50 to 0.90%) GQ (1.44 to 0.96 %) and GF (1.32 to 0.96%). At 15 minutes after the end of continuous rate infusion of fentanyl and lidocaine, expired fraction of isoflurane was increased 25% for GL and 45% for GF. Although there was no statistical difference, GF showed lower recovery score - 16.8 points, while 24.6 for GL, 30.0 for GQ and 31.8 points for GI. In conclusion, fentanyl was able to reduce end tidal isoflurane to 43%, with no side effects at recovery time after re-sedation with xylazine 0.5 mg / kg.
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Mendes, Marina Ceccato [UNESP]. "Efeitos cardiorrespiratórios da infusão contínua de amitraz ou de romifidina em equinos anestesiados com isofluorano. Determinação das concentrações plasmáticas do amitraz." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/101150.
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Com base na ação do amitraz (AMZ) e da romifidina (RMF) em receptores alfa-2 adrenérgicos e nas possíveis vantagens da associação destes fármacos com agentes inalatórios para uma anestesia geral segura, compararamse os efeitos clínicos, cardiocirculatórios e hemogasométricos da infusão contínua (IC) de AMZ ou de RMF associada ao isofluorano. Relacionaram-se os efeitos observados à concentração plasmática do amitraz (CPA) e investigaram-se possíveis efeitos farmacodinâmicos do diluente lipídico (DIL) utilizado na sua formulação. A medicação pré-anestésica (MPA) intravenosa (IV) para cada grupo foi: RMF - 60 μg/kg; AMZ - 0,2 mg/kg; DIL - 60 μg/kg de RMF. Induziu-se a anestesia com midazolam (0,1 mg/kg IV) e cetamina S(+) (0,2 mg/kg IV). A manutenção foi feita com 1,3 V% de isofluorano associado às ICs (RMF - 60 μg/kg.h; AMZ - 0,2 mg/kg.h; DIL - 0,1 mL/kg.h) por 60 minutos. Um minuto após a MPA a CPA média foi 396 ng/mL, aumentando durante a IC (de 93 ng/mL para 257 ng/mL) e diminuindo na recuperação, atingindo 47 ng/mL em 60 minutos. A RMF causou boa sedação e indução, com intubação fácil; manteve a FC estável e aumentou gradualmente a PAM, alterando pouco o CO2; resultou em recuperação ideal. O AMZ causou sedação leve e manteve planos anestésicos mais superficiais do que a RMF, com hipotensão durante a IC; a indução e a intubação foram de boa qualidade; o miorrelaxamento foi maior do que com RMF; a recuperação não teve boa qualidade. O DIL não causou sedação e resultou em recuperação de má qualidade, sendo inerte em relação aos efeitos do AMZ. Concluiu-se que há possibilidade do uso clínico do AMZ, ficando indicados estudos complementares.
Based on the action of amitraz (AMZ) and romifidine (RMF) on alpha-2 adrenergic receptors and in the possible advantages of combining them with inhalation anesthetics for a safe general anesthesia, the clinical, cardiocirculatory and hemogasometric effects of the continuous infusion (CI) of AMZ or RMF in association with isoflurane anesthesia were compared. The observed effects were related to the AMZ plasmatic levels (APL). The existence of pharmacodynamic effects of the lipid vehicle (LV) used for AMZ formulation was also investigated. The intravenous (IV) pre-anesthetic medications (PAM) were: RMF - 60 μg/kg; AMZ - 0.2 mg/kg; LV - 60 μg/kg de RMF. Anesthesia was inducted with midazolam (0.1 mg/kg IV) and S-ketamine (0.2 mg/kg IV) and maintained with 1.3 V% isoflurane, in association with the CIs (RMF - 60 μg/kg.h; AMZ - 0.2 mg/kg.h; LV - 0.1 mL/kg.h) for 60 minutes. One minute after PAM, APL was 396 ng/mL. During the CI, APL increased from 93 to 257 ng/mL. On recovery, APL decreased to 47 ng/mL in 60 minutes. With RMF there were good sedation and induction and the intubation was easy; HR was stable and MAP increased, with little CO2 alterations; the recovery was ideal. AMZ had less sedative effect and reached superficial anesthesia compared to RMF, with hypotension during CI; there were good induction and easy intubation; miorelaxation was greater with AMZ than with RMF; recovery was not good. The LV did not induce sedative effects and resulted in a poor recovery; it did not influence AMZ effects. The clinical use of AMZ is possible, but further studies are indicated.
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Castro, Vanessa Bastos [UNESP]. "Efeitos hemodinâmicos do cloridrato de dexmedetomidina administrado por infusão intravenosa contínua em cães anestesiados com propofol." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/105629.
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O emprego de procedimentos de anestesia intravenosa total em cães tem sido mais freqüente, devido ao melhor conhecimento do perfil farmacocinético dos fármacos empregados. Como ainda não existe um único fármaco que produza todas as características desejáveis em uma anestesia geral, há a necessidade de se associar ao hipnótico, agentes com propriedades analgésicas. O objetivo desse estudo foi avaliar os efeitos hemodinâmicos causados pela associação do cloridrato de dexmedetomidina, nas doses de 1 e 2 μg/kg/h, e propofol na dose de 0,3 mg/kg/min, administrada em infusão intravenosa contínua em cães, bem como o tempo de recuperação anestésica após duas horas de infusão. Seis cães, clinicamente sadios, sem raça definida, pesando 17,6±1,8 kg, foram submetidos a três tratamentos com intervalo de uma semana e em seqüência aleatória. Todos os animais foram inicialmente anestesiados com isofluorano a 5V% com fluxo de 3 l/min de O2. Após a indução e intubação, os animais foram posicionados em decúbito lateral esquerdo e mantidos com isofluorano na concentração de 1,8V%. As veias cefálicas e a artéria dorsal podal foram cateterizadas e um cateter de Swan Ganz 5F foi introduzido pela veia jugular. Após fixação dos cateteres na pele, a administração do isofluorano foi interrompida. Os cães permaneceram despertos por 1 hora, e após esse período, foi realizada a avaliação das variáveis hemodinâmicas. Em seguida os cães receberam um dos seguintes tratamentos: Controle: indução com propofol (6 mg/kg/30s) e solução de NaCl 0,9% (5 ml/10min) seguida de manutenção com propofol (0.3 mg/kg/min) e NaCl 0,9% (4 ml/h); Dex 1: indução com propofol (6 mg/kg/30s) e cloridrato de dexmedetomidina (1 μg/kg/10min) seguida de manutenção com propofol (0.3 mg/kg/min)...
Total intravenous anesthesia in dogs has been more frequently used, the pharmacokinetic profile of the new drugs is better understood. No injectable anesthetic produces all of the components of a general anesthesia, it is required to associate additional analgesics with hypnotic. The aim of this study was to evaluate the hemodynamic effects caused by the association of 1 and 2 μg/kg/h of dexmedetomidine and 0,3 mg/kg/min of propofol, administered by continuous intravenous infusion, as well time of anesthetic recovery after 2 hours of infusion. Six healthy dogs weighting 17,6±1,8 kg were randomly allocated to 3 treatments with at least one week intervals between each treatment. All animals were initially anesthetized with 5V% of isoflurane and 3 l/min of oxygen. After induction and intubation, the animals were posicionated in left lateral recumbence and maintained with 1.8% end tidal. All animals were instrumented with a cephalic veins and arterial catheter and a Swan Ganz catheter in order to a monitor hemodynamic parameters. After instrumentation isoflurane was interrupted and animals were awake and remained awake for one hour. After that, baselines parameters were taken. Dogs received each one of these treatments: Control: was induced with propofol (6 mg/kg/30s) and saline (5 ml/10 min), maintenance was with propofol (0.3 mg/kg/min) and saline (4 ml/h). Dex 1 was induced with propofol (6 mg/kg30s) and dexmedetomidine (1 μg/kg10 min), maintenance with propofol (0.3 mg/kg/min) and dexmedetomidine (1 μg/kg/h). Dex 2 was induced with propofol (6 mg/kg30s) and dexmedetomidine (2 μg/kg/10min), maintenance with propofol (0.3 mg/kg/min) and dexmedetomidine (2 μg/kg/h) during 120 minutes. The parameters (HR, SBP, MAP, DAP, CI, SI, CVP, PAP, POPA, SVRI, PVRI, RR, ETCO2, SaO2, pHa, PaO2, PaCO2, HCO3, Hb, CaO2, IDO2, temperature) were taken at 15, 30, 60, 90 e 120 minutes after induction... (Complete abstract click electronic access below)
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Beier, Suzane Lilian [UNESP]. "Infusão alvo-controlada com propofol e remifentanil: estudo experimental em cães." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/105646.
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Os modernos sistemas de infusao alvo-controlada (TCI), usados para a inducao e manutencao da anestesia, permitem que a velocidade de infusao seja ajustada atraves da utilizacao de avancados softwares alimentados com parametros farmacocineticos, de modo a assegurar uma adequada profundidade da anestesia e uma rapida e eficiente recuperacao. O objetivo inicial deste estudo foi determinar a concentracao plasmatica calculada de propofol (Cpcalculada) determinada por meio de estimulacao eletrica (50V, 50 Hz e 10 ms). Na segunda fase, o objetivo foi investigar a performance do uso de um sistema de infusao alvo-controlada de propofol usado isoladamente ou associado ao remifentanil. Paralelamente foram avaliados as respostas hemodinamicas e o periodo de recuperacao. A Performance e determinada pela Mediana da Performance do erro (MDPE), e a Mediana Absoluta da Performance do erro (MDAPE), sendo considerada clinicamente aceitavel uma MDPE de ate 20% e a MDAPE de ate 40%. Seis caes adultos saudaveis (26,6} 3,6kg) foram alocados aleatoriamente em 2 grupos com um intervalo de uma semana entre os experimentos. GI = TCI de propofol e G II = TCI de propofol + remifentanil. Os resultados foram analisados estatisticamente atraves da analise de variancia seguida pelo teste gt-Studenth. Foi considerado como significante um p<0,05. Houve uma reducao na frequencia cardiaca e indice cardiaco em GII, enquanto a pressao venosa central e a pressao de oclusao da arteria pulmonar aumentaram significativamente em GII comparado a GI. Os resultados obtidos para o grupo propofol foram de MDPE = 16,3% e MDAPE = 32,1% e para o grupo propofol+remifentanil foram de MDPE = 6,8% e MDAPE = 36,5%. A Cp50calculada foi de 2,0Êg.ml-1 (GI) e de 0,9Êg.ml-1 (GII)...
The target-controlled infusion systems (TCI), designed to keep the drug concentration in the bloodstream constant, are controlled by state-of-art software based upon pharmacokinetic models. These models have been designed for each species to produce an adequate anesthetic depth and fast and efficient recover. The aim of this study was to establish the predicted plasmatic concentration (Cppredicted) based upon electric stimulus (50V, 50 Hz and 10 ms). In a second phase, the aim was to investigate the anesthetic performance of the TCI of propofol used alone and associated with remifentanil. Moreover, haemodynamic parameters and anesthesia recovery time were evaluated. The performance was established based on the Median Performance error (MDPE < 20%) and Absolute Median Performance error (MDAPE < 40%). Six clinically normal dogs (26.6 l 3.6 kg) were randomly divided in 2 groups with at least one week between experiments. G1 = TCI of propofol alone; G2 = TCI of propofol + remifentanil. The statistical analysis was based on Student's t-distribution test, with alpha set at 0.05. Heart rate (HR) and cardiac index (CI) were significantly decreased after propofol + remifentanil (G2) infusion administration until the end, while central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP) were significantly increased. The G1 group demonstrated MDPE of 16.3% and MDAPE of 32.1%, whereas the G2 group had MDPE of 6.8% and MDAPE of 36.5%. The average Cp50predict for G1 was 2,0ìg.ml-1 and for G2 was 0,9ìg.ml-1. The evaluation of these parameters and the control of the anesthetic depth suggested that the TCI stanpump could be considered clinically acceptable in dogs. The remifentanil enhances the propofol's CPpredict in an average of 56.7%; however, haemodynamic side effects were detected.
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Hatschbach, Eduardo [UNESP]. "Estudo comparativo entre anestesia venosa total alvo-controlada e por infusão contínua em cães pré-tratados com levomepromazina e tratados com propofol e remifentanila." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/105639.
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A anestesia venosa total possui muitas vantagens, não polui ar ambiente, fácil de usar em lugares remotos, estabilidade cardiovascular e boa qualidade de recuperação. O propofol, devido sua farmacologia, é um dos fármacos mais usados em infusões contínuas. Recentes avanços têm acontecido na anestesia venosa total com a utilização de infusões alvo controlada, baseados em simulações farmacodinâmicas e farmacocinéticas dos fármacos em tempo real, inclusive na Medicina Veterinária. Em função disso, pretendeu-se colocar em prática este tipo de anestesia, utilizando-a em cadelas para a realização de cirurgias de ovariosalpingohisterectomia. Para isso foram anestesiadas 20 cadelas, após o consentimento livre e esclarecido dos proprietários. Sendo divididos em dois grupos (GI e GII). Em GI, os animais foram pré-tratados com levomepromazina na dose de 0,5mg/kg IV e anestesiados com propofol por infusão alvo controlada na dose de indução de 3,5æg/ml e na dose de manutenção de 1,5 æg/ml IV, através bomba de infusão Harvard pump, associado com remifentanila na dose de 0,3æg/kg/min, através de bomba de seringa. Em GII, os animais receberam o mesmo tratamento de GI, só que ao invés de receberem o propofol por infusão alvo controlada, receberam o propofol a 5mg/kg como dose de indução e como manutenção, receberam o propofol em infusão contínua de velocidade fixa, na dose de 0,2mg/kg/min. Assim, compararam-se as duas técnicas de infusão, a de velocidade fixa e a alvo controlada, concluindo-se que as doses de propofol utilizadas em ambas as técnicas, após o pré-tratamento de levomepromazina e associadas ao opióide, foram eficazes para a realização cirúrgica, promovendo bradicardia e discreta hipotensão, porém estabilidade hemogasométrica e respiratória...
Total venous anesthesia has many advantages as it does not pollute environmental air, can be easily used in remote sites, provides cardiovascular stability and good recovery quality. Due to its pharmacology, propofol is one of the most frequently used drugs in continuous infusions. Recently, advances have also been observed in total venous anesthesia with the use of target-controlled infusions based on real-time pharmacodynamic and pharmacokinetic drug simulations in Veterinary Medicine. As a result, this study aimed at applying this type of anesthesia by using it in female dogs for the performance of ovariosalpingohysterectomy surgery. To that end, twenty female dogs were anesthetized after free consent was given by their owners. The animals were divided into two groups (GI and GII). In GI, the dogs were pre-treated with methotrimeprazine at a dose of 0.5mg/kg IV and anesthetized with propofol by target-controlled infusion at an induction dose of 3.5æg/ml and a maintenance dose of 1.5 æg/ml IV by means of a Harvard infusion pump associated with remifentanil at a dose of 0.3æg/kg/min by means of a syringe pump. In GII, the animals received the same treatment as that given to GI, except that instead of receiving propofol by target-controlled infusion, they were given propofol at 5mg/kg as an induction dose. As maintenance, they received propofol by single-speed continuous infusion at a dose of 0.2mg/kg/min. Hence, two infusion techniques, fixed-speed infusion and target-controlled infusion, were compared, leading to the conclusion that the doses of propofol used in both techniques, after pre-treated with methotrimeprazine, associated with the opioid were efficient for surgery performance as they promoted bradycardia and discreet hypotension, but hemogasometric and respiratory stability, futher good muscle relaxation, more evident in fixed-speed infusion... (Complete abstract click electronic access below)
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Aldaek, Taher A. A. "Untersuchungen zur Beeinflussung der Konzentrationen von Glukose und Phosphat in Blut und Harn bei Milchkühen durch eine Glukoseinfusion." Giessen VVB Laufersweiler, 2009. http://d-nb.info/996005560/04.
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