Journal articles on the topic 'Influenza Victoria Prevention'
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Bennett, N. J., J. M. Bradford, A. L. Bull, and L. J. Worth. "Infection prevention quality indicators in aged care: ready for a national approach." Australian Health Review 43, no. 4 (2019): 396. http://dx.doi.org/10.1071/ah18052.
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Accreditation standards for Australian aged care homes include the requirement for programs to ensure infections are controlled. Effective infection prevention programs are supported by surveillance data providing the impetus for quality improvement and facilitating evaluation of interventions at the facility level. In 2016, infection control professionals employed in Victorian public-sector residential aged care services were surveyed to examine the nature and resourcing of local infection prevention programs and monitoring activities. Overall, 164 services participated (90% response rate). A high proportion (84%) reported executive support for infection surveillance, with mean allocation of 12h per fortnight per facility for infection prevention activities. Current surveillance activities included monitoring of infections and antimicrobial use (90%), influenza vaccination compliance for staff (96%) and residents (76%) and monitoring of infection due to significant organisms (84%). A successful statewide program including eight quality indicators has subsequently been implemented in Victoria. We suggest that a national focus could strengthen this framework, ensuring a uniform strategy with enhanced benchmarking capacity. Stakeholder engagement and refinement of appropriate indicators for monitoring quality improvement in public, not-for-profit and private sectors within aged care is required.
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Sistla, Sujatha. "Association between Serum Antibody Titers against Influenza Viruses and the Risk of Influenza in Patients with Chronic Respiratory Diseases - a Prospective, Longitudinal Study." Journal of Communicable Diseases 53, no. 03 (September 30, 2021): 69–75. http://dx.doi.org/10.24321/0019.5138.202140.
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Introduction: Patients with respiratory co-morbidities are the primary target group for influenza vaccination as chronic respiratory diseases pose a serious risk for unvaccinated individuals during influenza season. According to Centers for Disease Control and Prevention (CDC) guidelines, serum antibody titer of ≥ 40 is associated with “at least a 50% decrease in risk of acquiring influenza infection”. Methods: A prospective, longitudinal study was conducted in 345 patients with chronic respiratory diseases (April 2014-August 2015). Serum samples were tested for antibody levels against influenza A and B viruses using hemagglutination inhibition assay as per WHO protocol. These patients were followed up for one year and nasopharyngeal swab was collected from any patient who reported Influenza-like illness symptoms and subjected to real-time PCR for influenza viruses. Results: The seroprotective rates against influenza A (H1N1) pdm09, influenza A(H3N2), influenza B (Victoria and Yamagata) were 61%, 94%, 61%, 68% respectively. During the follow-up period of one year, 5 cases of influenza A/H3N2 and 7 cases of influenza B infection were identified while there were no cases of influenza A(H1N1)pdm09 infection. One case of influenza A/H3N2 infection was observed in an individual who had protective titers against the same virus while all 7 cases of influenza B infection occurred in people with non-protective titers against both the strains of influenza B viruses. Conclusion: Based on the findings of this study, it is proposed that in patients with chronic respiratory diseases influenza vaccination may be considered after more concrete information is obtained on correlates of protection against influenza subtypes.
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Ignatova, Galina L., and Vladimir N. Antonov. "The actuality of preventing influenza and pneumococcal infection during the ongoing COVID-19 pandemic." Consilium Medicum 23, no. 3 (2021): 275–79. http://dx.doi.org/10.26442/20751753.2021.3.200765.
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The article discusses the issues of vaccine prevention of influenza and pneumococcal infections during the ongoing pandemic of the new coronavirus infection COVID-19. Statistical data on the prevalence of these infections at the current time are provided. Co-infection can increase the symptoms of the diseases in these cases, and managing this condition is important for certain groups of patients. Respiratory viruses induce the attachment of pneumococcus, Pseudomonas aeruginosa and Hemophilus bacillus to the epithelial cells of the respiratory tract. The WHO position on influenza vaccination in the context of the COVID-19 pandemic is presented, and its main provisions are analyzed. Recommendations on the use of the main types of vaccines are given. Currently, the priority is to use 4-valent vaccines that ensure the development of the most stable immunity. In the Russian Federation, such a vaccine that meets all WHO recommendations is Ultrix Quadri, a tetravalent inactivated split influenza vaccine. The drug is a mixture of protective surface and internal antigens of influenza viruses of type A [subtypes A(H1N1) and A(H3N2)] and type B (Yamagata line and Victoria line). The use of vaccination schemes for pneumococcal infection was also discussed.
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Zhang, Cheng, Huan Cui, Zhongyi Wang, Shishan Dong, Chunmao Zhang, Jiaming Li, Keyin Meng, et al. "Pathogenicity and transmissibility assessment of two strains of human influenza virus isolated in China in 2018." Journal of International Medical Research 49, no. 1 (January 2021): 030006052098283. http://dx.doi.org/10.1177/0300060520982832.
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Objective Influenza season occurs every year in China, but its presentation was unusual in the period from December 2017 to early 2018. During this period, influenza activity was increasing across the country and was much greater than during the same period in previous years, with great harm to people’s health. Methods In this study, we isolated two human influenza virus strains—A/Hebei/F076/2018(H1N1) and B/Hebei/16275B/2018—from patients with severe influenza in Hebei, China, during the flu season in January 2018, and explored their genetic characteristics, pathogenicity, and transmissibility. Results A/Hebei/F076/2018(H1N1) belongs to the human-like H1N1 influenza virus lineage, whereas B/Hebei/16275B/2018 belongs to the Victoria lineage and is closely related to the World Health Organization reference strain B/Brisbane/60/2008. Pathogenicity tests revealed that A/Hebei/F076/2018(H1N1) replicated much more strongly in mice, with mice exhibiting 40% mortality, whereas B/Hebei/16275B/2018 was not lethal. Both viruses could be transmitted through direct contact and by the aerosol route between guinea pigs, but the H1N1 strain exhibited higher airborne transmissibility. Conclusions These results may contribute to the monitoring of influenza mutation and the prevention of an influenza outbreak.
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levin, myron J., Victoria Divino, Stephen I. Pelton, Maarten Postma, Drishti Shah, Joaquin F. Mould-Quevedo, and Mitchell DeKoven. "25. Relative Effectiveness of Adjuvanted Trivalent Influenza Vaccine Compared to Egg-Based Trivalent High-Dose Influenza Vaccine among U.S. Older Adults during 2019-20 Influenza Season." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S136. http://dx.doi.org/10.1093/ofid/ofab466.227.
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Abstract Background According to the Centers for Disease Control and Prevention (CDC), during the 2019-20 U.S. influenza season, influenza resulted in almost 180,000 hospitalizations and over 13,000 deaths in adults ≥ 65 years. The current study evaluated the relative vaccine effectiveness (rVE) of adjuvanted trivalent influenza vaccine (aTIV) compared to high-dose trivalent influenza vaccine (TIV-HD), against influenza-related hospitalizations/emergency room (ER) visits, all-cause hospitalizations and hospitalizations/ER visits for cardio-respiratory disease (CRD) among adults ≥65 years for the 2019-20 influenza season. Methods A retrospective cohort analysis of older adults (≥ 65 years) was conducted using IQVIA’s professional fee, prescription claims and hospital charge master data in the U.S. Baseline characteristics included age, gender, payer type, geographic region, Charlson Comorbidity Index (CCI), comorbidities, indicators of frail health status, and pre-index hospitalization rates. To avoid any influenza outcome misclassification with COVID-19 infection, the study period ended March 7, 2020. Adjusted analyses were conducted through inverse probability of treatment weighting (IPTW) to control for selection bias. Poisson regression was used to estimate the adjusted pairwise rVE against influenza-related hospitalizations/ER visits, all-cause hospitalizations and any hospitalization/ER visit for CRD. An unrelated negative control outcome, urinary tract infection (UTI) hospitalization was included. Results During the 2019-20 influenza season, following IPTW, 798,987 recipients of aTIV and 1,655,979 recipients of TIV-HD were identified. After IPTW adjustment and Poisson regression, aTIV was statistically comparable to TIV-HD for prevention of influenza-related hospitalizations/ER visits (3.1%; 95% CI: -2.8%-8.6%) and all-cause hospitalizations (-0.7%; 95% CI: -1.6%-0.3%). Similar comparable outcomes were found for reduction of any hospitalization/ER visit for CRD (0.9%; 95% CI: 0.0%-1.7%). No treatment effect was identified for the negative control outcome. Conclusion aTIV and TIV-HD demonstrated comparable reductions in influenza-related hospitalizations/ER visits, all-cause hospitalizations and hospitalizations/ER visits for CRD. Disclosures myron J. levin, MD, GSK group of companies (Employee, Research Grant or Support) Victoria Divino, PhD, Seqirus (Consultant) Stephen I. Pelton, MD, Seqirus (Consultant) Maarten Postma, Dr., Seqirus (Consultant) Drishti Shah, PhD, Seqirus (Consultant) Joaquin F. Mould-Quevedo, PhD, Seqirus (Employee) Mitchell DeKoven, PhD, Seqirus (Consultant)
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Lazareva, N. B. "Influenza in the COVID-19 era: principles of modern pharmacotherapy." Meditsinskiy sovet = Medical Council, no. 16 (October 30, 2021): 100–108. http://dx.doi.org/10.21518/2079-701x-2021-16-100-108.
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Influenza is one of the most common infectious diseases and a significant public health problem. Every year, the influenza virus causes 3–5 million severe cases, millions hospitalizations and approximately 650,000 deaths. According to WHO four new influenza strains are projected to circulate in the 2020–2021 epidemic season. Influenza A and B strains are: A/Guangdong-Maonan/ SWL1536/2019 (H1N1) pdm09, A/Hong Kong/2671/2019 (H3N2), B/Washington/02/2019 (Victoria lineage), B/ Phuket/3073/2013 (Yamagata lineage). In this context, the problem of prescribing rational antiviral therapy is particularly importance. COVID-19, along with influenza, is a group of respiratory viral infections, but important differences exist in terms of viral agents and the spread of infection. Important differences include the rate of transmission. The average incubation period and generation time (the time between infecting one person and infecting another) for influenza are shorter. COVID-19 may be more severe, causing complications and deaths in 3–4% of cases. The estimated generation time for COVID 19 is 5-6 days, while for influenza it is 3 days. According to the latest data, the reproductive number, i.e., the number of people who can be infected by one patient, is in the range of 2 to 2.5 in COVID 19, which is higher than in influenza. Only a laboratory test can accurately identify the type of pathogen and distinguish it from influenza and other respiratory viruses. Neuraminidase inhibitors are currently first-line drugs recommended by WHO for the treatment and prevention of influenza.
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Levin, James, Allen Borchardt, Thanh Lam, Wanlong Jiang, Zhi-Yong Chen, Joanne Fortier, Suzanne Akers-Rodriguez, et al. "689. Therapeutic Efficacy of CB-012, a Novel Cloudbreak Antiviral Fc-Conjugate (AVC) in Lethal Mouse Models of Influenza A (H1N1) and Influenza B (Victoria)." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S313. http://dx.doi.org/10.1093/ofid/ofz360.757.
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Abstract Background In 2018, the World Health Organization estimated up to 650,000 influenza-related respiratory deaths occur annually. Cidara therapeutics is developing a novel class of potent, long-acting antiviral Fc-conjugates (AVCs) against influenza that in a single molecule combine a surface-acting antiviral agent with the Fc domain of a human IgG1 antibody. AVCs function by inhibiting viral replication while simultaneously engaging the immune system, providing a multimodal mechanism of action. Here we present efficacy data on an AVC development candidate against influenza A and B. Methods Efficacy studies were conducted in female BALB/c mice (6–8 weeks) challenged intranasally with 3x the LD95 of influenza A/Puerto Rico/8/1934 (H1N1) or B/Malaysia/2506/04. CB-012 or CB-012b (CB-012 with slightly modified Fc) was administered as a single intravenous (IV) dose 2 hours after challenge. Oseltamivir was dosed orally, twice daily for 5 days in the influenza A study. Vehicle and appropriate Fc controls were included. Body weights (BW) and mortality were monitored for 2 weeks; animals with 20% BW loss, or moribund, were scored as a death. Results In an initial study of CB-012 against influenza A, a single IV dose of 0.4 mg/kg was fully protective and statistically significant compared with the Fc control (P = 0.0027). In contrast, mice treated with oseltamivir at 5 mg/kg twice daily for 5 days were not protected; only the higher 20 mg/kg dose was fully protective. Importantly, mice treated with CB-012 (0.4 mg/kg) showed a transient BW loss of 1% compared with 14% in mice of the oseltamivir (20 mg/kg) group, although treatment was initiated at the same time. In a second study against influenza B, CB-012b was fully protective with a single IV dose at 0.3 mg/kg (P = 0.0027). In contrast, vehicle and Fc control groups reached mortality by day 6. BW loss in the CB-012b 0.3 mg/kg group was transient and <4% overall during the study. Conclusion The novel AVCs CB-012 and CB-012b demonstrated robust efficacy in multiple influenza models. In conjunction with previous findings against influenza A (H3N2), the data on CB-012 support its potential as a candidate against seasonal influenza. The continued development of CB-012 for the prevention and treatment of influenza is warranted. Disclosures All authors: No reported disclosures.
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Sidwell, Robert W., Donald F. Smee, John H. Huffman, Dale L. Barnard, Kevin W. Bailey, John D. Morrey, and Y. S. Babu. "In Vivo Influenza Virus-Inhibitory Effects of the Cyclopentane Neuraminidase Inhibitor RWJ-270201." Antimicrobial Agents and Chemotherapy 45, no. 3 (March 1, 2001): 749–57. http://dx.doi.org/10.1128/aac.45.3.749-757.2001.
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ABSTRACT The cyclopentane influenza virus neuraminidase inhibitor RWJ-270201 was evaluated against influenza A/NWS/33 (H1N1), A/Shangdong/09/93 (H3N2), A/Victoria/3/75 (H3N2), and B/Hong Kong/05/72 virus infections in mice. Treatment was by oral gavage twice daily for 5 days beginning 4 h pre-virus exposure. The influenza virus inhibitor oseltamivir was run in parallel, and ribavirin was included in studies with the A/Shangdong and B/Hong Kong viruses. RWJ-270201 was inhibitory to all infections using doses as low as 1 mg/kg/day. Oseltamivir was generally up to 10-fold less effective than RWJ-270201. Ribavirin was also inhibitory but was less tolerated by the mice at the 75-mg/kg/day dose used. Disease-inhibitory effects included prevention of death, lessening of decline of arterial oxygen saturation, inhibition of lung consolidation, and reduction in lung virus titers. RWJ-270201 and oseltamivir, at doses of 10 and 1 mg/kg/day each, were compared with regard to their effects on daily lung parameters in influenza A/Shangdong/09/93 virus-infected mice. Maximum virus titer inhibition was seen on day 1, with RWJ-270201 exhibiting the greater inhibitory effect, a titer reduction of >104 cell culture 50% infective doses (CCID50)/g. By day 8, the lung virus titers in mice treated with RWJ-270201 had declined to 101.2 CCID50/g, whereas titers from oseltamivir-treated animals were >103CCID50/g. Mean lung consolidation was also higher in the oseltamivir-treated animals on day 8. Both neuraminidase inhibitors were well tolerated by the mice. RWJ-270201 was nontoxic at doses as high as 1,000 mg/kg/day. These data indicate potential for the oral use of RWJ-270201 in the treatment of influenza virus infections in humans.
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Levin, James, Karin Amundson, Kim Shathia, Allen Borchardt, Thanh Lam, Tom Brady, Alain Noncovich, and Les Tari. "159. efficacy of CD377, a Novel Antiviral Fc-conjugate, Against Seasonal Influenza in Lethal Mouse Infection Models." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S209. http://dx.doi.org/10.1093/ofid/ofaa439.469.
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Abstract Background Cidara’s AVCs (antiviral Fc-conjugates) are novel conjugates of potent, antiviral agents with the Fc domain of human IgG1. CD377 is an AVC development candidate for prevention and treatment of influenza that has broad anti-neuraminidase activity in both enzymatic and cell-based assays and the potential to engage the immune system, as well as a long half-life. Methods Efficacy studies were conducted in BALB/c mice lethally challenged intranasally at 3x the LD95 with influenza A (H1N1, H3N2) and influenza B (both lineages). CD377 was administered as a single dose subcutaneously (SC) 2 hours after viral challenge. Body weights (BW) and health scores were monitored daily, with 20% BW loss recorded as a mortality. Results In mice challenged with a lethal dose of an H1N1 strain (A/California/12/2012), a single 0.3 mg/kg dose of CD377 administered 2 hours post-challenge was fully protective (P=0.0015 relative to vehicle) (Fig 1A). In a similar study against a mouse-adapted H3N2 subtype (A/Hong Kong/1/1968), a single dose of CD377 at 0.1 mg/kg was fully protective (P=0.0025) (Fig 1B). In both studies, only a transient loss of BW was observed before mice began recovering weight. The activity of CD377 was also evaluated against both lineages of influenza B (Fig 1C, 1D). Against influenza B/Colorado/06/2017 (Victoria), a single CD377 dose of 0.3 mg/kg was fully protective (P=0.0035) while the Fc-only control dosed at 1 mg/kg was not, as expected. Against the Yamagata lineage (B/Florida/4/2006), CD377 demonstrated full protection at a dose of only 0.03 mg/kg (P=0.0023). Conclusion A single dose of CD377 (0.3 mg/kg or less) was protective against lethal challenge with several seasonal influenza A/B subtypes. The exceptional PK profile of CD377 combined with potent broad-spectrum activity highlight its potential for use as a long-term preventative against seasonal influenza. Seasonal influenza efficacy Disclosures James Levin, PhD, Cidara Therapeutics (Shareholder) Karin Amundson, BSc, Cidara Therapeutics (Shareholder) Allen Borchardt, PhD, Cidara Therapeutics (Employee) Thanh Lam, PhD, Cidara Therapeutics (Shareholder) Tom Brady, PhD, Cidara Therapeutics (Shareholder) Alain Noncovich, PhD, Cidara Therapeutics (Shareholder) Les Tari, PhD, Cidara Therapeutics (Shareholder)
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Ong, Voon, James Levin, Allen Borchardt, Thomas P. Brady, Thanh Lam, Alain Noncovich, Joanne Fortier, et al. "1283. New Generation Antiviral Conjugate (AVC): Stable, Safe, and Single." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S656—S657. http://dx.doi.org/10.1093/ofid/ofaa439.1466.
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Abstract Background CD377 is a novel antiviral Fc-conjugate (AVC) development candidate for influenza prevention and treatment, comprising multiple copies of a novel potent small-molecule antiviral and the Fc domain of human IgG1. CD377 was designed as a stable, long-acting molecule for treatment and prevention of influenza A and B. Studies were conducted to characterize CD377 stability/pharmacokinetics (PK), single-dose efficacy in influenza models, and safety/toxicology. Methods PK in the mouse (1-100 mg/kg), rat (5-50 mg/kg), ferret (3 mg/kg), and monkey (5-20 mg/kg) were studied by sampling plasma over a 1-2 week interval. Plasma levels of intact molecule and total Fc were measured by neuraminidase (NA)-capture and Fc-capture with Fc-detection ELISA, respectively. Two-week safety/toxicology (bodyweight, coagulation, clinical signs, chemistries, hematology, cytokines, urinalsis, histopathology) was evaluated in monkeys (5-20 mg/kg on days 1 and 8). Prophylaxis efficacy was studied in a lethal influenza mouse model using a single dose of CD377 (0.3–3 mg/kg) 28 days prior to intranasal (IN) challenge with 3x the LD95 of A/California/07/2009 (H1N1)pdm, A/Hong Kong/1/68 (H3N2), or B/Malaysia (Victoria lineage). Treatment efficacy was studied in a similar mouse model using a single dose of CD377 (0.3–3 mg/kg) administered 2 hours after IN challenge with A/CA/12/2012 (H1N1)pdm. Results Plasma concentrations measured by Fc-capture/Fc-detection and NA-capture/Fc-detection were comparable, indicating that CD377 remained intact in vivo. In species tested, CD377 t1/2 was 3–10 days. Dose proportional increases in exposure were observed, notably from 1–100 mg/kg in mouse. High bioavailability (77%) was observed after subcutaneous (SC) or intramuscular (IM) administration. A single SC dose of 1 mg/kg administered 28 days prior to infection provided 100% protection against H1N1, B, and H3N2 subtypes in mouse (Fig. 1). Treatment efficacy was observed with a single 0.3 mg/kg IM dose. The 2-week monkey toxicology study showed no adverse effects. Figure 1. Efficacy (Survival and Body Weight) of CD377 in a 28-Day Prevention Model Against Influenza H1N1, H3N2, and B Subtypes in Mouse (IN infection challenge on Day t=0 and CD377 dosed t–28 days). Conclusion The stability and safety of CD377, together with its long half-life and efficacy with a single dose, support the potential of CD377 as a long-acting, novel AVC for the prevention and treatment of influenza. Disclosures Voon Ong, PhD, Cidara Therapeutics, Inc. (Employee, Shareholder) James Levin, PhD, Cidara Therapeutics (Shareholder) Allen Borchardt, PhD, Cidara Therapeutics (Employee) Thomas P. Brady, PhD Chemistry, Cidara Therapeutics (Employee) Thanh Lam, PhD, Cidara Therapeutics (Shareholder) Alain Noncovich, PhD, Cidara Therapeutics (Shareholder) Joanne Fortier, BSc, Cidara Therapeutics (Employee, Shareholder) Karin Amundson, B.S., Cidara Therapeutics (Shareholder) Jeffrey B. Locke, PhD, Cidara Therapeutics, Inc. (Employee, Shareholder) Amanda Almaguer, Bachelors, Cidara Therapeutics, Inc. (Employee, Shareholder) Nicholas Dedeic, n/a, Cidara Therapeutics (Employee) Grayson Hough, MS - Chemistry, Cidara Therapeutics (Employee) Jason Cole, PhD, Cidara Therapeutics (Shareholder) Simon Döhrmann, PhD, Cidara Therapeutics (Shareholder) Rajvir Grewal, n/a, Cidara Therapeutics, Inc. (Employee, Shareholder) Elizabeth Abelovski, B.S., Cidara Therapeutics (Shareholder) James M. Balkovec, PhD, Cidara Therapeutics (Consultant, Shareholder) Ken Bartizal, PhD, Cidara Therapeutics, Inc. (Consultant, Shareholder) Les Tari, PhD, Cidara Therapeutics (Shareholder)
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Pelton, Stephen I., Maarten Postma, Victoria Divino, Drishti Shah, Joaquin F. Mould-Quevedo, Mitchell DeKoven, and Girishanthy Krishnarajah. "6. MF59 ASSURANCE 2: A Real-world Study to Estimate the Relative Vaccine Effectiveness of Adjuvanted Trivalent Influenza Vaccine Compared to Egg-based Trivalent High-dose Among U.S. Older Adults During 2018–19 Influenza Season." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S3. http://dx.doi.org/10.1093/ofid/ofaa417.005.
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Abstract Background In the 2018–19 influenza season, influenza resulted in almost 280,000 hospitalizations and over 25,000 deaths in U.S. adults > 65 years. This study aimed to evaluate the relative vaccine effectiveness (rVE) of adjuvant trivalent influenza vaccine (aTIV) compared to high-dose trivalent influenza vaccine (TIV-HD), against influenza-related hospitalizations/emergency room (ER) visits, office visits and hospitalization/ER visit for cardio-respiratory disease (CRD) among older adults for the 2018–19 flu season. Methods A retrospective cohort analysis of older adults (> 65 years) was conducted using professional fee, prescription claims and hospital charge master data in the U.S. Baseline characteristics included age, gender, payer type, region, Charlson Comorbidity Index (CCI), comorbidities, indicators of frail health status, and pre-index hospitalization rates. Adjusted analyses were conducted through inverse probability of treatment weighting (IPTW) to control for selection bias. Poisson regression was used to estimate the adjusted pairwise rVE against influenza-related hospitalizations/ER visits and office visits and any hospitalization/ER visit for CRD (based on diagnoses codes). An unrelated outcome, urinary tract infection (UTI) hospitalization, was assessed. Results During 2018–19 flu season, following IPTW analyses, 561,315 recipients of aTIV and 1,672,779 of TIV-HD were identified. After IPTW adjustment and Poisson regression, aTIV was more effective in reducing influenza-related office visits compared to TIV-HD (6.6%; 95% CI: 2.8%-10.3%). aTIV was statistically comparable to TIV-HD (2.0%; 95% CI: -3.7%-7.3%) for prevention of influenza-related hospitalizations/ER visits but more effective than TIV-HD (2.6%; 95% CI: 2.0%-3.2%) in reducing hospitalizations/ER visits for CRD. No treatment effect was identified for control condition (UTI hospitalization). Conclusion In adjusted analyses, aTIV reduced influenza-related office visits and CRD hospitalizations/ER visits compared to TIV-HD. aTIV and TIV-HD demonstrated comparable reductions in influenza-related hospitalizations/ER visits. Disclosures Stephen I. Pelton, MD, Merck vaccine (Consultant, Grant/Research Support)Pfizer (Consultant, Grant/Research Support)Sanofi Pasteur (Consultant, Other Financial or Material Support, DSMB)Seqirus Vaccine Ltd. (Consultant) Maarten Postma, Dr., IQVIA (Consultant) Victoria Divino, PhD, Seiqrus Vaccines Ltd. (Consultant) Drishti Shah, PhD, Seqirus Vaccines Ltd. (Consultant) Joaquin F. Mould-Quevedo, PhD, Seqirus Vaccines Ltd. (Employee, Shareholder) Mitchell DeKoven, PhD, Seqirus Vaccines Ltd. (Consultant) Girishanthy Krishnarajah, PhD, Seqirus Vaccines Ltd. (Employee, Shareholder)
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Postma, Maarten, Stephen I. Pelton, Victoria Divino, Joaquin F. Mould-Quevedo, Drishti Shah, and Mitchell DeKoven. "14. A Comprehensive Real-World Analysis to Compare Adjuvanted Trivalent Influenza Vaccine and Trivalent High Dose Influenza Vaccine by Age and Period of High Influenza Activity for the 2018–19 Season among U.S. Elderly." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S29—S30. http://dx.doi.org/10.1093/ofid/ofaa439.059.
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Abstract Background Influenza vaccine effectiveness decreases with increasing age due to the senescence of immune function and a reduced immune response to antigens. There is also considerable vaccine effectiveness heterogeneity depending on the influenza activity time period, especially in seasons where two different circulating strains predominated, such as the 2018–19 season. This research aimed to assess the effect of age and high influenza activity period (HIAP) on the relative vaccine effectiveness (rVE) of adjuvanted trivalent influenza vaccine (aTIV) vs. trivalent high-dose influenza vaccine (HD-TIV) among elderly (≥65y) recipients in the U.S. Methods During the 2018–19 influenza season, a retrospective cohort analysis was conducted using professional fee, prescription claims and hospital charge master data in the U.S. The first sub-analysis evaluated rVE for different age groups (65–74 years, 75–84 years, ≥85 years). The second sub-analysis evaluated rVE overall, restricting the observation period from to HAIP: Dec 2018-Mar 2019 (August 2018-July 2019 in the main analysis). Adjusted analyses were conducted through inverse probability of treatment weighting (IPTW) to control for selection bias. Poisson regression was used to estimate the adjusted pairwise rVE for influenza-related hospitalizations/emergency room (ER) visits and office visits. Results Following IPTW, 561,315 recipients of aTIV and 1,672,779 of TIV-HD were identified. Following IPTW adjustment and Poisson regression, aTIV was more effective in reducing influenza-related office visits compared to TIV-HD (7.0%; 95% CI: 2.6%-11.2%) in the HIAP sub-analysis. In the age sub-analysis, the rVE favoring aTIV ranged from 5.1% (95% CI: -0.17%-10.1%) for the youngest group (65–74) up to 11.4% (95% CI: 0.6%-21.1%) for the eldest group (≥85y) for influenza-related office visits. No statistically significant differences were found for aTIV compared to TIV-HD for prevention of influenza-related hospitalizations/ER visits in the sub-analyses evaluated. Conclusion In adjusted analyses, aTIV reduced influenza-related office visits compared to TIV-HD within the two older age groups and HIAP sub-analysis. aTIV and TIV-HD demonstrated comparable reductions in influenza-related hospitalizations/ER visits. Disclosures Maarten Postma, Dr., IQVIA (Consultant) Stephen I. Pelton, MD, Merck vaccine (Consultant, Grant/Research Support)Pfizer (Consultant, Grant/Research Support)Sanofi Pasteur (Consultant, Other Financial or Material Support, DSMB)Seqirus Vaccine Ltd. (Consultant) Victoria Divino, PhD, Seiqrus Vaccines Ltd. (Consultant) Joaquin F. Mould-Quevedo, PhD, Seqirus Vaccines Ltd. (Employee, Shareholder) Drishti Shah, PhD, Seqirus Vaccines Ltd. (Consultant) Mitchell DeKoven, PhD, Seqirus Vaccines Ltd. (Consultant)
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Chang, Leejah, Evan J. Anderson, Robert Jeanfreau, Ying He, Bryony Hicks, Anju Shrestha, Aseem Pandey, Rawia Khoury, Iris De Bruijn, and Victoria Landolfi. "160. Safety and Immunogenicity of Escalating Dose Formulations of High-dose Quadrivalent Influenza Vaccine in Children 6 Months Through < 18 Years of Age." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S209—S210. http://dx.doi.org/10.1093/ofid/ofaa439.470.
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Abstract Background Children do not respond immunologically as well as adults to standard-dose (SD) influenza vaccination and remain at increased risk of influenza and its complications. A method to improve efficacy in children may be to increase antigen amount per dose, a successful strategy used in older adults. Trivalent high-dose (HD) influenza vaccine (60ug hemagglutinin/strain) showed significantly improved effectiveness for prevention of clinical outcomes related to influenza in adults ≥65 years; moreover, a quadrivalent HD formulation was approved by US FDA (2019) for use in this group. Methods A Phase 2, randomized, modified double blind study (NCT03698279) was conducted in US and Canadian children to evaluate safety and immunogenicity of IIV4-HD compared to an IIV4-SD and adjuvanted trivalent influenza vaccine (aIIV3). Children (n=661, 6 months through < 18 years) were assigned to receive intramuscularly 1 of 3 formulations of IIV4-HD (30, 45, or 60 µg HA/strain/dose), a licensed IIV4-SD, or a licensed aIIV3. Depending on child’s previous influenza vaccination status and age, they received 1 or 2 doses of study vaccine 28 days apart. Post-vaccination (28 days after each vaccination) geometric mean titers (GMTs) and seroconversion rates were measured using hemagglutinin inhibition (HAI) assay. Reactogenicity data were collected through 1 week; safety data were collected through 6 months post-vaccination. Results IIV4-HD was more reactogenic than IIV4-SD, but unsolicited related adverse events were similar (Table 1). No related serious adverse events or deaths occurred. A dose-related increase in HAI GMT ratio was observed across the age range for A/H3N2 but only in children 6 months through < 3 years for A/H1N1 and the 2 B strains (Table 2). Compared with IIV4-SD, the 60 µg HA/strain/dose formulation of IIV4-HD generated highest HAI GMT ratios and high seroconversion rates for all 4 strains in US children 6 months through < 3 years. Canadian children receiving IIV4-HD generated HAI titers incongruent to those of US children receiving IIV4-HD, limiting direct comparison against aIIV3. Safety Overview (US and Canadian subjects 6 months through <18 years) HAI GMT Ratios (QIV-HD/QIV-SD) at 28 days After the Last Vaccination (US subjects 6 months through <18 years) Conclusion The favorable safety profile and the HAI GMT ratios support pediatric dose selection of 60µg HA/strain/dose as most appropriate to evaluate in Phase 3. Disclosures Leejah Chang, MD, Sanofi Pasteur (Employee) Evan J. Anderson, MD, Sanofi Pasteur (Scientific Research Study Investigator) Robert Jeanfreau, MD, Sanofi Pasteur (Scientific Research Study Investigator) Ying He, PhD, Otsuka Pharmaceutical (Employee)Sanofi Pasteur (Other Financial or Material Support, Former employee) Bryony Hicks, BSc, Sanofi Pasteur (Employee) Anju Shrestha, MD, Sanofi Pasteur (Employee) Aseem Pandey, PhD, Sanofi Pasteur (Employee)Sanofi Pasteur (Employee) Rawia Khoury, BSc, Sanofi Pasteur (Employee) Iris De Bruijn, PhD, Sanofi Pasteur (Employee) Victoria Landolfi, MS, MBA, Sanofi Pasteur (Employee)
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Campbell, Angela P., Constance Ogokeh, Geoffrey A. Weinberg, Julie A. Boom, Janet A. Englund, John V. Williams, Natasha B. Halasa, et al. "Effect of Vaccination on Preventing Influenza-Associated Hospitalizations Among Children During a Severe Season Associated With B/Victoria Viruses, 2019–2020." Clinical Infectious Diseases 73, no. 4 (January 27, 2021): e947-e954. http://dx.doi.org/10.1093/cid/ciab060.
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Abstract Background The 2019–2020 influenza season was characterized by early onset with B/Victoria followed by A(H1N1)pdm09 viruses. Emergence of new B/Victoria viruses raised concerns about possible vaccine mismatch. We estimated vaccine effectiveness (VE) against influenza-associated hospitalizations and emergency department (ED) visits among children in the United States. Methods We assessed VE among children aged 6 months–17 years with acute respiratory illness and ≤10 days of symptoms enrolled at 7 pediatric medical centers in the New Vaccine Surveillance Network. Combined midturbinate/throat swabs were tested for influenza virus using molecular assays. Vaccination history was collected from parental report, state immunization information systems, and/or provider records. We estimated VE from a test-negative design using logistic regression to compare odds of vaccination among children testing positive vs negative for influenza. Results Among 2029 inpatients, 335 (17%) were influenza positive: 37% with influenza B/Victoria alone and 44% with influenza A(H1N1)pdm09 alone. VE was 62% (95% confidence interval [CI], 52%–71%) for influenza-related hospitalizations, 54% (95% CI, 33%–69%) for B/Victoria viruses, and 64% (95% CI, 49%–75%) for A(H1N1)pdm09. Among 2102 ED patients, 671 (32%) were influenza positive: 47% with influenza B/Victoria alone and 42% with influenza A(H1N1)pdm09 alone. VE was 56% (95% CI, 46%–65%) for an influenza-related ED visit, 55% (95% CI, 40%–66%) for B/Victoria viruses, and 53% (95% CI, 37%–65%) for A(H1N1)pdm09. Conclusions Influenza vaccination provided significant protection against laboratory-confirmed influenza-associated hospitalizations and ED visits associated with the 2 predominantly circulating influenza viruses among children, including against the emerging B/Victoria virus subclade.
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Clemann, Nick. "Cold-blooded indifference: a case study of the worsening status of threatened reptiles from Victoria, Australia." Pacific Conservation Biology 21, no. 1 (2015): 15. http://dx.doi.org/10.1071/pc14901.
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For the first time in the history of life, a biodiversity extinction crisis is being driven by a single species – humans. Humans also have unprecedented control over both the threats and conservation actions that influence this crisis. When prioritising conservation actions, innate human bias often favours endothermic vertebrates over other fauna. Reptiles are the least popular terrestrial vertebrate class, and consequently are particularly disadvantaged in terms of being listed as threatened and receiving conservation management. Despite 30 years of formally evaluating and listing threatened vertebrates in the Australian State of Victoria, there is a strong worsening trend in the conservation status of all faunal groups. The deteriorating status of Victorian reptiles mirrors worrying documented trends in reptile conservation status around the world. I review the history of listing threatened reptiles in Victoria, detail worsening trends in their conservation status, and suggest that, as in other parts of the world, the threats common to most listed taxa are climate change, habitat loss and degradation, and elevated rates of predation by exotic predators. I also identify poor advice and planning as a considerable threat to Victorian reptiles; this threat is rarely reported, but may be more pervasive than currently recognised. I argue that what is needed for most reptiles to have the greatest chance of persisting in the long term is prevention of habitat loss and degradation, research to underpin listing and management, improved policy so that unproven management strategies are not sanctioned, and vetting of consultant’s reports so that unproven ‘mitigation’ strategies and inadequate preimpact surveys do not mask the true cost of loss and degradation of habitat.
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Clarke, Brydie, Boyd Swinburn, and Gary Sacks. "Understanding Health Promotion Policy Processes: A Study of the Government Adoption of the Achievement Program in Victoria, Australia." International Journal of Environmental Research and Public Health 15, no. 11 (October 29, 2018): 2393. http://dx.doi.org/10.3390/ijerph15112393.
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Despite the growing health and economic burden associated with overweight and obesity, preventive policy progress has been deficient globally. This study investigated the policy process involved in the adoption of the Achievement Program, a settings-based health promotion intervention that was a key pillar of the Healthy Together Victoria obesity prevention initiative. The qualitative study utilised multiple theories of the policy process, as well as Causal Loop Diagramming (CLD) methods, to understand the policy systems underlying the decision to adopt the Achievement Program. Factors that impacted this obesity prevention policy adoption included problem prioritisation at Federal and state government levels; political risks regarding policy action and inaction, and framing used by policy advocates to reduce risks and highlight the opportunities related to the Achievement Program policy implementation. The use of CLD methods was advantageous to further conceptualise potential leverage points and effective ways to influence obesity prevention policy in future. As such, the findings contribute to the obesity prevention policy evidence base and toward developing a number of recommended actions for policy actors seeking to increase future policy action.
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Clapperton, Angela, Stuart Newstead, Lyndal Bugeja, and Jane Pirkis. "Differences in Characteristics and Exposure to Stressors Between Persons With and Without Diagnosed Mental Illness Who Died by Suicide in Victoria, Australia." Crisis 40, no. 4 (July 2019): 231–39. http://dx.doi.org/10.1027/0227-5910/a000553.
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Abstract. Background: Mental illness is an established risk factor for suicide. To develop effective prevention interventions and strategies, the demographic characteristics and stressors (other than, or in addition to, mental illness) that can influence a person's decision to die by suicide need to be identified. Aim: To examine cases of suicide by the presence or absence of a diagnosed mental illness (mental illness status) to identify differences in factors associated with suicide in the groups. Method: Logistic regression analyses were used to investigate mental illness status and exposure to stressors among 2,839 persons who died by suicide in Victoria, Australia (2009–2013), using the Victorian Suicide Register. Results: Females, metropolitan residents, persons treated for physical illness/injury, those exposed to stressors related to isolation, family, work, education, and substance use and those who had made a previous suicide attempt had increased odds of having a diagnosed mental illness. Employed persons had decreased odds of having a diagnosed mental illness. Limitations: The retrospectivity of data collection as well as the validity and reliability of some of the data may be questionable owing to the potential for recall bias. Conclusion: The point of intervention for suicide prevention cannot always be a mental health professional; some people who die by suicide either do not have a mental illness or have not sought help.
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Groothuis, Jessie R., Gordon Meiklejohn, Brian A. Lauer, Myron J. Levin, and Gerard P. Rabalais. "Immunization of High-Risk Infants Younger Than 18 Months of Age with Split-Product Influenza Vaccine." Pediatrics 87, no. 6 (June 1, 1991): 823–28. http://dx.doi.org/10.1542/peds.87.6.823.
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Influenza is an important cause of serious illness in very young children with cardiopulmonary disease. A 4-year study was conducted at two centers to assess immunogenicity and safety of influenza split-product vaccine in children aged 3 to 18 months with bronchopulmonary dysplasia and congenital heart disease. A total of 113 children were studied: 62 children 3 to 5 months of age and 51 children 6 to 18 months of age. Sera were drawn prior to first and second immunization and 3 weeks after second immunization and were tested by hemagglutination inhibition; protection was defined as >1:32. Ninety-five children were surveyed for adverse reactions. Seroresponses were age and antigen specific. Best responses for all ages were to A/Mississippi (H3N2) (97%). Children older than 6 months of age had better seroresponses to A/Leningrad (H3N2) (73%, P < .03) and B/Victoria (62%, P < .02) than did children younger than 6 months of age. Seroconversion rates to the remaining anere low. Only 9% of children experienced adverse reactions; all but one were mild. The immunologic mechanisms responsible for preventing serious influenzal disease and more effective immunization strategies need to be defined for very young high-risk children.
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Kobie, James, Michael Piepenbrink, Aitor Nogales, and Luis Martinez-Sobrido. "Induction and isolation of protective influenza neuraminidase specific antibodies in humans following seasonal vaccination." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 60.17. http://dx.doi.org/10.4049/jimmunol.200.supp.60.17.
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Abstract Influenza’s propensity for antigenic drift and shift, and to elicit predominantly strain specific antibodies (Abs) leaves humanity susceptible to waves of new strains with pandemic potential for which limited or no immunity may exist. Subsequently new clinical interventions are needed, particularly those with broad activity against diverse strains. Although hemagglutinin (HA) specificity dominates the humoral response to seasonal inactivated influenza vaccines and infection, Abs targeting neuraminidase (NA) are also generated. NA-specific Abs are suggested to act primarily through inhibiting its enzymatic activity and preventing release of virus from infected cells. Relative to HA, there is substantially less diversity among NA from different influenza types and subtypes, suggesting it is a valuable target for inducing broad protective immunity. To determine if humans generate NA-specific Abs with protective activity we examined plasmablasts from subjects that were immunized with the seasonal influenza inactivated vaccine, and isolated several NA-specific human monoclonal Abs (hmAbs), including those with potent in vitro viral neutralizing activity. One of the NA B–specific hmAbs, KPF2 recognized NA from both the Yamagata and Victoria lineages, and when administered prophylactically to mice resulted in sterilizing immunity. These results suggest seasonal influenza vaccine induces protective NA-specific mAbs in humans. Analysis of other NA-specific hmAbs is ongoing.
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Roussy, Véronique, Therese Riley, Charles Livingstone, and Grant Russell. "A system dynamic perspective of stop–start prevention interventions in Australia." Health Promotion International 35, no. 5 (September 24, 2019): 1015–25. http://dx.doi.org/10.1093/heapro/daz098.
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Abstract Time-limited prevention initiatives are frequently used to address complex and persisting public health issues, such as non-communicable diseases. This often creates issues in terms of achieving sustainable change. In this study, we use a system dynamic perspective to explore the effects of stop–start funding over system behaviour in two community-based initiatives designed to prevent chronic diseases and obesity. We conducted a qualitative exploratory study using complexity theory as an analytical lens of two Healthy Together Communities (HTCs) initiatives in Victoria, Australia. Data were generated from 20 semi-structured interviews with health promotion practitioners and managers, from community health and local government organizations. Template analysis based on properties of complex systems informed the inductive identification of system behaviour narratives across the stop–start life-course of HTCs. A central narrative of system behaviour emerged around relationships. Within it, we identified pre-existing contextual conditions and intervention design elements that influenced non-linearity of system self-organization and adaptation, and emergence of outcomes. Examples include cynicism, personal relationships and trust, and history of collaboration. Feedback loops operated between HTCs and these conditions, in a way that could influence long-term system behaviour. Taking a dynamic life-course view of system behaviour helps understand the pre-existing contextual factors, design and implementation influences, and feedback loops which shape the long-term legacy of short-lived interventions aimed at solving complex issues. In turn, greater awareness of such interactions can inform better design and implementation of community-based interventions.
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Jones, Jeremy C., Bindumadhav M. Marathe, Christian Lerner, Lukas Kreis, Rodolfo Gasser, Philippe Noriel Q. Pascua, Isabel Najera, and Elena A. Govorkova. "A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus ActivityIn Vitro." Antimicrobial Agents and Chemotherapy 60, no. 9 (July 5, 2016): 5504–14. http://dx.doi.org/10.1128/aac.00888-16.
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ABSTRACTAntiviral drugs are important in preventing and controlling influenza, particularly when vaccines are ineffective or unavailable. A single class of antiviral drugs, the neuraminidase inhibitors (NAIs), is recommended for treating influenza. The limited therapeutic options and the potential risk of antiviral resistance are driving the search for additional small-molecule inhibitors that act on influenza virus proteins. The acid polymerase (PA) of influenza viruses is a promising target for new antivirals because of its essential role in initiating virus transcription. Here, we characterized a novel compound, RO-7, identified as a putative PA endonuclease inhibitor. RO-7 was effective when added before the cessation of genome replication, reduced polymerase activity in cell-free systems, and decreased relative amounts of viral mRNA and genomic RNA during influenza virus infection. RO-7 specifically inhibited the ability of the PA endonuclease domain to cleave a nucleic acid substrate. RO-7 also inhibited influenza A viruses (seasonal and 2009 pandemic H1N1 and seasonal H3N2) and B viruses (Yamagata and Victoria lineages), zoonotic viruses (H5N1, H7N9, and H9N2), and NAI-resistant variants in plaque reduction, yield reduction, and cell viability assays in Madin-Darby canine kidney (MDCK) cells with nanomolar to submicromolar 50% effective concentrations (EC50s), low toxicity, and favorable selective indices. RO-7 also inhibited influenza virus replication in primary normal human bronchial epithelial cells. Overall, RO-7 exhibits broad-spectrum activity against influenza A and B viruses in multiplein vitroassays, supporting its further characterization and development as a potential antiviral agent for treating influenza.
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Naccarella, Lucio, Michelle Raggatt, and Bernice Redley. "The Influence of Spatial Design on Team Communication in Hospital Emergency Departments." HERD: Health Environments Research & Design Journal 12, no. 2 (September 20, 2018): 100–115. http://dx.doi.org/10.1177/1937586718800481.
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Objective: To identify spatial design factors that influence informal interprofessional team-based communication within hospital emergency departments (EDs). Background: Effective team communication in EDs is critical for interprofessional collaborative care and prevention of serious errors due to miscommunication. Limited evidence exists about how informal communication in EDs is shaped by the physical workspace and how workplace design principles can improve the quality of ED team communication. Method: Two health services with four hospital sites in Victoria, Australia, participated. A multistage mixed-methods approach used (1) an anonymous online communication network survey ( N = 103) to collect data on patterns and locations of informal interprofessional team communication among ED staff, (2) focus groups ( N = 37) and interviews ( N = 3) using photoelicitation to understand the perspectives of ED staff about how spatial design influences team communication, and (3) validity testing of preliminary findings with executives and ED managers at the participating sites. Results: Informal communication with peers and within discipline groups on nonspecific areas of the ED was most common. Three key factors influenced the extent to which ED workspaces facilitated informal communication: (1) staff perceptions of privacy, (2) staff perceptions of safety, and (3) staff perceptions of connectedness to ED activity. Conclusion: Our research supports the proposition that ED physical environments influence informal team communication patterns. To facilitate effective team communication, ED workspace spatial designs need to provide visibility and connectedness, support and capture “case talk,” enable privacy for “comfort talk,” and optimize proximity to patients without compromising safety.
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Judd, A. K., A. Sanchez, D. J. Bucher, J. H. Huffman, K. Bailey, and R. W. Sidwell. "In vivo anti-influenza virus activity of a zinc finger peptide." Antimicrobial Agents and Chemotherapy 41, no. 3 (March 1997): 687–92. http://dx.doi.org/10.1128/aac.41.3.687.
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Matrix protein (M1) is a major structural protein of influenza virus, and it inhibits its own polymerase. A 19-amino-acid peptide, corresponding to a zinc finger region of the M1 sequence of influenza virus strain A/PR/8/34 (H1N1), centered around amino acids 148 to 166, was synthesized. This peptide, designated peptide 6, represents a zinc finger which includes a 7-amino-acid loop or finger and a 4-amino-acid tail at the carboxyl terminus, in addition to the 8 amino acids involved in the coordination of Zn. Three experiments were run to evaluate the activity of peptide 6 on infections induced in mice by influenza A/PR/8/34 and A/Victoria/3/75 (H3N2) viruses. Intranasal (i.n.) treatment of the H1N1 virus infection with 30 or 60 mg/kg of body weight/day, three times daily for 5 days, beginning 4 h pre-or 8 h post-virus exposure, was effective in preventing death, reducing the arterial oxygen decline, and inhibiting lung consolidation. Virus titers in the lungs determined on day 5 were reduced by up to 1.5 log10 in treated groups, but considerable variation in the titers of the recovered virus was seen. The H3N2 virus infection was treated i.n. with 30, 60, or 120 mg of peptide 6/kg/day by using the above-mentioned delayed initiation treatment schedule, and similar protection was seen, although lung virus titers were not reduced in the day-5 assay. Peptide 6 was well tolerated at doses up to 60 mg/kg/day. This zinc finger peptide may provide a new class of antivirals effective against influenza virus.
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Krasilnikov, I. V., A. V. Ivanov, A. M. Nikolaeva, O. V. Belyakova, E. K. Shevchenko, N. A. Mikhailova, I. A. Leneva, and V. V. Zverev. "Preclinical study of immunogenicity of adjuvanted quadrivalent subunit influenza vaccine." Journal of microbiology, epidemiology and immunobiology 99, no. 3 (July 28, 2022): 300–308. http://dx.doi.org/10.36233/0372-9311-244.
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Background. Preventive vaccination is a vitally important strategic aspect of protection of the population against severe effects of influenza epidemics. The priority attention is given to development of effective tetravalent vaccines containing antigens of two influenza A lineages (H1N1, H3N2) and two influenza B lineages (Victoria and Yamagata) in combination with immunoadjuvants.The aim of the work was to conduct the preclinical study of the immunogenicity and protective efficacy of the innovative tetravalent subunit vaccine containing antigens of influenza A and B viruses as well as a corpuscular adjuvant.Materials and methods. The study was conducted using female BALB/c mice. The tetravalent vaccine and monovalent intermediate vaccines combined with a betulin adjuvant were injected intraperitoneally two times at a 14-day interval. The immunogenic activity was measured by the hemagglutination inhibition assay. The protective activity of the vaccine was assessed by changes in the viral load, body weight and survival rates using the mouse model of fatal influenza A H1N1 virus infection.Results. The mice vaccinated with the adjuvanted quadrivalent subunit influenza vaccine produced antibodies against all four influenza viruses included in the vaccine; the mean antibody titers in the hemagglutination inhibition assay were above 1 : 40. The second-dose vaccination induced a significant increase in levels of antibodies against all four influenza viruses. The dose of the quadrivalent subunit adjuvanted vaccine containing 5 µg of each antigen and 200 µg of the adjuvant provided a 100% survival rate in mice and significantly decreased lung viral titers (more than 3 lg TCID50) in the mouse model of influenza pneumonia.Conclusion. The quadrivalent subunit vaccine with the betulin-based corpuscular adjuvant demonstrates high immunogenicity in laboratory mice and provides protection against fatal pneumonia caused by the influenza A virus subtype H1N1.
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Tumwine, Christopher, Peter Aggleton, and Stephen Bell. "Enhancing HIV Prevention: Social Support, Access to, and Use of HIV Testing, Treatment, and Care Services in Fishing Communities Around Lake Victoria, Uganda." AIDS Education and Prevention 32, no. 3 (June 2020): 196–211. http://dx.doi.org/10.1521/aeap.2020.32.3.196.
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In-depth interviews were conducted with 42 HIV-positive fisherfolk and 15 health care providers to identify experiences of social support and its influence on access to and use of HIV testing, treatment, and care. Fisherfolk participants reported receiving support at some point. Prior to HIV diagnosis, this usually took the form of advice on what illness they were dealing with and remedies to use. After HIV diagnosis and disclosure to friends or family, emotional support enabled fisherfolk to come to terms with an HIV diagnosis, informational support offered guidance on how best to live with HIV, while instrumental support enabled access to relevant HIV services. Finally, affiliative support, in the form of new friends met through HIV clinic visits, provided a sense of belonging. Each of these different kinds of support assisted fisherfolk to respond positively to HIV with important consequences for secondary and tertiary prevention.
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Hesketh, Kylie, Melissa Wake, Elizabeth Waters, John Carlin, and David Crawford. "Stability of body mass index in Australian children: a prospective cohort study across the middle childhood years." Public Health Nutrition 7, no. 2 (April 2004): 303–9. http://dx.doi.org/10.1079/phn2003537.
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AbstractObjective:To investigate the prevalence and incidence of overweight and obesity, the frequency of overweight resolution and the influence of parental adiposity during middle childhood.Design:As part of a prospective cohort study, height and weight were measured in 1997 and 2000/2001. Children were classified as non-overweight, overweight or obese based on standard international definitions. Body mass index (BMI) was transformed into age- and gender-specific Z-scores employing the LMS method and 2000 growth chart data of the Centers for Disease Control and Prevention. Parents self-reported height and weight, and were classified as underweight, healthy weight, overweight or obese based on World Health Organization definitions.Setting:Primary schools in Victoria, Australia.Subjects:In total, 1438 children aged 5–10 years at baseline.Results:The prevalence of overweight and obesity increased between baseline (15.0 and 4.3%, respectively) and follow-up (19.7 and 4.8%, respectively; P < 0.001 for increase in overweight and obesity combined). There were 140 incident cases of overweight (9.7% of the cohort) and 24 of obesity (1.7% of the cohort); only 3.8% of the cohort (19.8% of overweight/obese children) resolved to a healthy weight. The stability of child adiposity as measured by BMI category (84.8% remained in the same category) and BMI Z-score (r = 0.84; mean change = −0.05) was extremely high. Mean change in BMI Z-score decreased with age (linear trend β = 0.03, 95% confidence interval 0.01–0.05). The influence of parental adiposity largely disappeared when children's baseline BMI was adjusted for.Conclusions:During middle childhood, the incidence of overweight/obesity exceeds the proportion of children resolving to non-overweight. However, for most children adiposity remains stable, and stability appears to increase with age. Prevention strategies targeting children in early childhood are required.
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Bbosa, Nicholas, Deogratius Ssemwanga, Rebecca N. Nsubuga, Noah Kiwanuka, Bernard S. Bagaya, John M. Kitayimbwa, Alfred Ssekagiri, Gonzalo Yebra, Pontiano Kaleebu, and Andrew Leigh-Brown. "Phylogenetic Networks and Parameters Inferred from HIV Nucleotide Sequences of High-Risk and General Population Groups in Uganda: Implications for Epidemic Control." Viruses 13, no. 6 (May 24, 2021): 970. http://dx.doi.org/10.3390/v13060970.
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Phylogenetic inference is useful in characterising HIV transmission networks and assessing where prevention is likely to have the greatest impact. However, estimating parameters that influence the network structure is still scarce, but important in evaluating determinants of HIV spread. We analyzed 2017 HIV pol sequences (728 Lake Victoria fisherfolk communities (FFCs), 592 female sex workers (FSWs) and 697 general population (GP)) to identify transmission networks on Maximum Likelihood (ML) phylogenetic trees and refined them using time-resolved phylogenies. Network generative models were fitted to the observed degree distributions and network parameters, and corrected Akaike Information Criteria and Bayesian Information Criteria values were estimated. 347 (17.2%) HIV sequences were linked on ML trees (maximum genetic distance ≤4.5%, ≥95% bootstrap support) and, of these, 303 (86.7%) that consisted of pure A1 (n = 168) and D (n = 135) subtypes were analyzed in BEAST v1.8.4. The majority of networks (at least 40%) were found at a time depth of ≤5 years. The waring and yule models fitted best networks of FFCs and FSWs respectively while the negative binomial model fitted best networks in the GP. The network structure in the HIV-hyperendemic FFCs is likely to be scale-free and shaped by preferential attachment, in contrast to the GP. The findings support the targeting of interventions for FFCs in a timely manner for effective epidemic control. Interventions ought to be tailored according to the dynamics of the HIV epidemic in the target population and understanding the network structure is critical in ensuring the success of HIV prevention programs.
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Akobi, William Kala, John Paul Oyore, and George Ochieng Otieno. "Effects of behavioural change communication on HIV and AIDS related high risk behaviour among fishermen in Homabay and Siaya Counties, Kenya." International Journal Of Community Medicine And Public Health 9, no. 6 (May 27, 2022): 2334. http://dx.doi.org/10.18203/2394-6040.ijcmph20221503.
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Background: Risky sexual behaviors such as sexual concurrency, sexual networks (fish for sex exchange) and unprotected sex, have been reported as the main cause of sexually transmitted diseases (STIs) /HIV infections among fisher folks. Behavioral change mechanisms as condom use and abstinence are some of interventions used in prevention HIV/AIDS spread in Kenya. Risky sexual behaviors increase risk of contracting STIs including HIV/AIDSMethods: This was a cross-sectional descriptive study involving 246 randomly selected fisher folks in Mbita- and Usenge along Lake Victoria. The survey used questionnaires to collect data among respondents. Using a sample frame in the beach management unit offices, fisherfolks were identified and invited to participate. Consent was obtained from participantsResults: The mean age of respondents was 31 years old. The 72% of the participants were directly involved in fishing. Participants who had extra marital relationship though married were 56.1% in Mbita and 47% in Usenge. Respondents who took alcohol with friends were 94.1% in Mbita and 96.2% in Usenge. Respondents who indicated that they had unprotected sex under influence of alcohol were 48.3% in Mbita and 77.1% in Usenge. Those who were sexually taken advantage of while under the influence of alcohol were 23.8% in Mbita and 38.3% in Usenge while those had sexually taken advantage of under the influence of alcohol were 18.3% in Mbita and 37.8% in Usenge.Conclusions: Targeted behaviour change communication (BCC) strategies designed specifically for fisherfolks is needed to curb high incidences of risky sexual behaviours noted among the fishermen.
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Berridge, Bonita J., Terence V. McCann, Ali Cheetham, and Dan I. Lubman. "Perceived Barriers and Enablers of Help-Seeking for Substance Use Problems During Adolescence." Health Promotion Practice 19, no. 1 (February 1, 2017): 86–93. http://dx.doi.org/10.1177/1524839917691944.
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Aim. Receiving professional help early can reduce long-term harms associated with substance use. However, little is known about the factors that influence help-seeking for substance use problems during early-mid adolescence, prior to the emergence of disorder. Given that beliefs regarding help-seeking are likely to develop early, understanding adolescent views of help-seeking during this period is likely to provide important information for prevention and intervention efforts. The current study identifies perceptions that would facilitate or prevent adolescents from seeking support for substance use problems from formal and informal help sources. Method. Thirty-four 12- to 16-year-olds from two schools in Melbourne, Victoria, Australia, were recruited. A qualitative interpretative design was used, incorporating semistructured, audio-recorded interviews. Results. Three overlapping themes that reflected barriers or enablers to help-seeking were identified: approachability, confidentiality and trustworthiness, and expertise. Help-seeking was facilitated when adolescents believed that the help source would be supportive and understanding, would keep information confidential, and had expertise in the alcohol and drug field. Conversely, adolescents were reluctant to seek help from sources they believed would be judgmental, lacked expertise, or would inform their parents. Conclusions. These findings highlight perceptions that may influence help-seeking for alcohol and drug problems during adolescence. Further research is needed to determine if help-seeking can be facilitated by improving parents’ and peers’ knowledge and promoting health professionals’ expertise in working with young people’s alcohol and drug issues.
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Divino, Victoria, Maarten Postma, Stephen I. Pelton, Joaquin F. Mould-Quevedo, Ruthwik Anupindi, Mitchell DeKoven, and myron J. levin. "96. Relative Vaccine Effectiveness Against Influenza-Related and Any Respiratory-Related Hospital Encounter During the 2019/20 High Influenza Activity Period: A Comprehensive Real-World Analysis to Compare Quadrivalent Cell-based and Egg-based Influenza Vaccines." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S61. http://dx.doi.org/10.1093/ofid/ofab466.096.
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Abstract Background Changes in the influenza hemagglutinin protein during replication of influenza in eggs during vaccine production may contribute to low vaccine effectiveness (VE). This phenomenon, egg adaptation, can explain VE differences between egg-based (QIVe-SD) and cell-based (QIVc) quadrivalent influenza vaccines. This research evaluated the relative vaccine effectiveness (rVE) of QIVc versus QIVe-SD in the reduction of influenza-related and any respiratory-related hospitalizations/emergency room (ER) visits among subjects 4-64 years old during the 2019/20 influenza season. Methods A retrospective cohort analysis was conducted among subjects 4-64 years old vaccinated with QIVc or QIVe-SD using administrative claims data in the U.S. (IQVIA PharMetrics® Plus). The adjusted number of events and rates of influenza-related hospitalizations/ER visits and respiratory-related hospitalizations/ER visits were assessed using inverse probability of treatment weighting (IPTW). Poisson regression was used to estimate relative vaccine effectiveness (rVE). In the main analysis, the study period was from Aug 4, 2019 to Mar 7, 2020 (ending early to avoid any influenza outcome misclassification with COVD-19 infection). In the assessment of the high influenza activity period (HIAP), the analysis period was restricted to Dec 8, 2019 to Mar 7, 2020. Results During the 2019/20 influenza season, 1,150,134 recipients of QIVc and 3,924,819, of QIVe-SD were identified following IPTW. In the main analysis, adjusted results show that QIVc was associated with a significantly higher rVE compared to QIVe-SD against influenza-related hospitalizations/ER visits (5.3% [95%CI: 0.5%-9.9%]) and respiratory-related hospitalizations/ER visits (8.2% [95%CI: 6.5%-9.8%]). Similarly, in the HIAP analysis, QIVc was associated with a significantly higher rVE compared to QIVe-SD for influenza-related hospitalizations/ER visits (5.7% [95%CI: 0.8%-10.4%]) and respiratory-related hospitalizations/ER visits (7.3% [95%CI: 5.4%-9.2%]). Conclusion QIVc was more effective in preventing influenza-related and respiratory-related hospitalizations/ER visits compared to QIVe-SD, using either a broad influenza season definition or restricting to the HIAP. Disclosures Victoria Divino, PhD, Seqirus (Consultant) Maarten Postma, Dr., Seqirus (Consultant) Stephen I. Pelton, MD, Seqirus (Consultant) Joaquin F. Mould-Quevedo, PhD, Seqirus (Employee) Ruthwik Anupindi, PhD, Seqirus (Consultant) Mitchell DeKoven, PhD, Seqirus (Consultant) myron J. levin, MD, GSK group of companies (Employee, Research Grant or Support)
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Pelton, Stephen I., Maarten Postma, Victoria Divino, Joaquin F. Mould-Quevedo, Ruthwik Anupindi, Mitchell DeKoven, and myron J. levin. "1341. Relative Vaccine Effectiveness Against Influenza-related Hospitalizations and Respiratory Events During the 2019/20 Influenza seAson in U.S. Children and Adults. A Real-World Evidence Comparison Between Quadrivalent Cell-based and Egg-based Influenza Vaccines." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S758. http://dx.doi.org/10.1093/ofid/ofab466.1533.
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Abstract Background Non-egg-based influenza vaccine manufacturing reduces egg adaptation and therefore has the potential to increase vaccine effectiveness. This study evaluated whether the cell-based quadrivalent influenza vaccine (QIVc) improved relative vaccine effectiveness (rVE) compared to standard-dose egg-based quadrivalent influenza vaccine (QIVe-SD) in the reduction of influenza-related and respiratory-related hospitalizations/emergency room (ER) visits among subjects 4-64 years old during the 2019/20 influenza season. Methods A retrospective analysis was conducted among subjects 4-64 years old vaccinated with QIVc or QIVe-SD using administrative claims data in the United States of America (U.S.) (IQVIA PharMetrics® Plus). Inverse probability of treatment weighting (IPTW) was used to adjust for baseline confounders. Post-IPTW, the number of events and rates (per 1,000 vaccinated subject-seasons) of influenza-related hospitalizations/ER visits, respiratory-related hospitalizations/ER visits and all-cause hospitalizations were assessed. Poisson regression was used to estimate adjusted rVE. To avoid any influenza outcome misclassification with COVID-19 infection, the study period ended March 7,2020. A sub-analysis for a high-risk subgroup was conducted. Urinary tract infection (UTI) hospitalization was assessed as a negative control endpoint. Results During the 2019/20 influenza season, 1,150,134 QIVc and 3,924,819 QIVe-SD recipients were identified post-IPTW. Overall adjusted analyses (4-64 years old) found that QIVc was associated with a significantly higher rVE compared to QIVe-SD against influenza-related hospitalizations/ER visits (5.3% [95% CI: 0.5%-9.9%]), all-cause hospitalizations (14.5% [95% CI: 13.1%-15.8%]) and any respiratory-related hospitalization/ER visit (8.2% [95% CI: 6.5%-9.8%]). A similar trend was seen for the high-risk subgroup; for instance, rVE for QIVc compared to QIVe-SD against influenza-related hospitalizations/ER visits was 10.5% [95% CI: 2.9%-17.4%]. No effect was identified for the negative control outcome. Conclusion QIVc was significantly more effective in preventing influenza-related and respiratory-related hospitalizations/ER visits, as well as all-cause hospitalizations, compared to QIVe-SD. Disclosures Stephen I. Pelton, MD, Seqirus (Consultant) Maarten Postma, Dr., Seqirus (Consultant) Victoria Divino, PhD, Seqirus (Consultant) Joaquin F. Mould-Quevedo, PhD, Seqirus (Employee) Ruthwik Anupindi, PhD, Seqirus (Consultant) Mitchell DeKoven, PhD, Seqirus (Consultant) myron J. levin, MD, GSK group of companies (Employee, Research Grant or Support)
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Puig-Barberà, Joan, Beatriz Guglieri-López, Miguel Tortajada-Girbés, F. Xavier López-Labrador, Mario Carballido-Fernández, Joan Mollar-Maseres, Germán Schwarz-Chavarri, Víctor Baselga-Moreno, Ainara Mira-Iglesias, and Javier Díez-Domingo. "Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season." Vaccine 35, no. 52 (December 2017): 7331–38. http://dx.doi.org/10.1016/j.vaccine.2017.10.100.
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Timperio, Anna, David Cameron-Smith, Catherine Burns, and David Crawford. "The public's response to the obesity epidemic in Australia: weight concerns and weight control practices of men and women." Public Health Nutrition 3, no. 4 (December 2000): 417–24. http://dx.doi.org/10.1017/s1368980000000483.
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AbstractObjectiveTo assess weight perceptions, weight concerns and weight control behaviours and related beliefs in a representative sample of adults.DesignCross-sectional postal survey.SettingThe survey was conducted between October and December 1997 in the state of Victoria, Australia.SubjectsA total of 2500 subjects were selected at random from the Australian electoral roll; 900 provided usable responses.ResultsAt the time of the survey, 2.7% of respondents were trying to gain weight, 26.6% were trying to avoid gaining weight, 22.9% were trying to lose weight and 47.9% were not doing anything for their weight. Men (47.2%) were less likely than women (55.3%) to be attempting any form of weight control. Watching the type of food eaten (95.6%), reducing dietary fat intake (87.3%) and engaging in physical activity or exercise (84.4%) were the most common weight control strategies used. Potentially harmful strategies, such as self-induced vomiting and smoking, were used by relatively few respondents. Many adults believed that vigorous activity (26.8%) and total omission of fat from the diet (35.3%) are necessary in order to lose weight.ConclusionsAttempts at weight control are common in the community. However, many men, including men who are already overweight, appear to be unconcerned about their weight. Obesity prevention initiatives should attempt to influence individuals' weight-related beliefs and behaviours, as well as seeking to change policies and environments to better support weight control.
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Dabkowski, Elissa, Simon Cooper, Jhodie Duncan, and Karen Missen. "Exploring Hospital Inpatients’ Awareness of Their Falls Risk: A Qualitative Exploratory Study." International Journal of Environmental Research and Public Health 20, no. 1 (December 27, 2022): 454. http://dx.doi.org/10.3390/ijerph20010454.
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Patient falls in hospital may lead to physical, psychological, social and financial impacts. Understanding patients’ perceptions of their fall risk will help to direct fall prevention strategies and understand patient behaviours. The aim of this study was to explore the perceptions and experiences that influence a patient’s understanding of their fall risk in regional Australian hospitals. Semi-structured, individual interviews were conducted in wards across three Australian hospitals. Participants were aged 40 years and over, able to communicate in English and were mobile prior to hospital admission. Participants were excluded from the study if they returned a Standardised Mini-Mental State Examination (SMMSE) score of less than 18 when assessed by the researcher. A total of 18 participants with an average age of 69.8 years (SD ± 12.7, range 41 to 84 years) from three regional Victorian hospitals were interviewed for this study. Data were analysed using a reflexive thematic analysis identifying three major themes; (1) Environment (extrinsic) (2) Individual (intrinsic), and (3) Outcomes, as well as eight minor themes. Participants recognised the hazardous nature of a hospital and their personal responsibilities in staying safe. Falls education needs to be consistently delivered, with the focus on empowering the patient to help them adjust to changes in their clinical condition, whether temporary or permanent.
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Serdyuk, Marina, Dmytrо Stepanenko, Olesia Priss, Tatiana Kopylova, Nonna Gaprindashvili, Alina Kulik, Vita Atanasova, Maryana Kashkano, and Julia Kozonova. "INVESTIGATION OF THE INFLUENCE OF ANTIOXIDANT COMPOSITIONS ON DEVELOPMENT OF MICROBIOLOGICAL SPOILAGE IN STORAGE OF FRUITS." EUREKA: Life Sciences 3 (May 31, 2017): 24–29. http://dx.doi.org/10.21303/2504-5695.2017.00355.
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The studies are devoted to the scientific grounding of expedience of after-harvest processing by antioxidant compositions for preventing the development of pathogenic microflora on fruit surfaces during a long storage. For the studies were used apple fruits of the varieties Aidared, Golden Dushesse, Renet Simirenka, pear fruits of the varieties Victoria, Crimea Raisin and Cure, plum fruits of the varieties Voloshka, Stanley and Italian Ugorka. Fruits were processed by immersion in the following antioxidant compositions: ACM is a mixture of dimethyl sulfoxide, ionol and polyethylene glycols; AARL – mixture of ascorbic acid, routin and lecithin; DL – mixture of dimethyl sulfoxide, ionol and lecithin. Fruits, processed by water, were used as a control. Exposition - 10 seconds. Storage was carried out at the temperature 0±1 ºС, relative air humidity 90–95 %. It was established that in the period of fruits laying for storage, the mean amount of epiphyte microflora was fixed on surfaces of plump and pear fruits of the mean ripening term. In the variety composition of epiphyte microflora prevailed spores of mesophyl aerobic and facultative-anaerobic microorganisms. Their mean number on apple fruits surface was 9,6·103 CCU/g, pear fruits – 10,6 103 CCU/g, plump fruits – 18·103CCCU/g. AOC processing of all types of fruits essentially decreased the speed of both MAFAnM and micromycetes growth. It was demonstrated that the used compositions in 2…3,5 times decreased the level of day losses from microbiological spoilage during the whole storage period. The most positive effect was received at using compositions, based on dystinol and lecithin. Multifactor analysis determined that the level of day losses from microbiological spoilage was mainly influenced by factors of raw material variety features (factor A) and antioxidant compositions processing (factor D). The shares of influence are 24 and 21 % respectively.
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Prior, Margot, Diana Smart, Ann Sanson, and Frank Oberklaid. "Longitudinal Predictors of Behavioural Adjustment in Pre-Adolescent Children." Australian & New Zealand Journal of Psychiatry 35, no. 3 (June 2001): 297–307. http://dx.doi.org/10.1046/j.1440-1614.2001.00903.x.
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Objectives: Longitudinal data from infancy onwards, from the Australian Temperament Project, a prospective study of the temperament and development of a large and representative sample of Victorian children, were examined to identify predictors of psychological disorder at 11–12 years of age. Method: Those children scoring in the at-risk range for psychological disorder according to parents, teachers and self-reports using the Child Behaviour Questionnaire were selected at 11–12 years of age for in-depth assessment and comparison with a group of children with no history of adjustment problems. Analyses of group differences using longitudinal data gathered from infancy to 12 years focused on parent and teacher reports on child temperament and behaviour, and various facets of home and school adjustment. Results: The strongest predictors of adjustment at 12 years were previous behaviour problems, along with some specific temperament factors involving self-regulation capacities and mother's overall rating of child difficulty. Results based on parallel teacher data including peer adjustment, and social and academic competence measures were consistent with parent data. Conclusions: Our research confirms the persistence of early appearing behaviour problems in a community sample and the longitudinal influence of temperament factors in childhood. The study supports the need for a focus on early intervention and prevention strategies in the child mental health field.
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Waller, R. A., and P. W. G. Sale. "Persistence and productivity of perennial ryegrass in sheep pastures in south-western Victoria: a review." Australian Journal of Experimental Agriculture 41, no. 1 (2001): 117. http://dx.doi.org/10.1071/ea00049.
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Loss of perennial ryegrass (Lolium perenne L.) from the pasture within several years of sowing is a common problem in the higher rainfall (550–750 mm annual rainfall), summer-dry regions of south-eastern Australia. This pasture grass came to Australia from northern Europe, where it mostly grows from spring to autumn under mild climatic conditions. In contrast, the summers are generally much drier and hotter in this region of south-eastern Australia. This ‘mismatch’ between genotype and environment may be the fundamental reason for the poor persistence. There is hope that the recently released cultivars, Fitzroy and Avalon, selected and developed from naturalised ryegrass pastures in south-eastern Australia for improved winter growth and persistence will improve the performance of perennial ryegrass in the region. Soon-to-be released cultivars, developed from Mediterranean germplasm, may also bridge the climatic gap between where perennial ryegrass originated and where it is grown in south-eastern Australia. Other factors that influence perennial ryegrass persistence and productivity can be managed to some extent by the landholder. Nutrient status of the soil is important since perennial ryegrass performance improves relative to many other pasture species with increasing nitrogen and phosphorus supply. It appears that high soil exchangeable aluminium levels are also reducing ryegrass performance in parts of the region. The use of lime may resolve problems with high aluminium levels. Weeds that compete with perennial ryegrass become prevalent where bare patches occur in the pasture; they have the opportunity to invade pastures at the opening rains each year. Maintaining some herbage cover over summer and autumn should reduce weed establishment. Diseases of ryegrass are best managed by using resistant cultivars. Insect pests may be best managed by understanding and monitoring their biology to ensure timely application of pesticides and by manipulating herbage mass to alter feed sources and habitat. Grazing management has potential to improve perennial ryegrass performance as frequency and intensity of defoliation affect dry matter production and have been linked to ryegrass persistence, particularly under moisture deficit and high temperature stress. There is some disagreement as to the merit of rotational stocking with sheep, since the results of grazing experiments vary markedly depending on the rotational strategy used, climate, timing of the opening rains, stock class and supplementary feeding policy. We conclude that flexibility of grazing management strategies is important. These strategies should be able to be varied during the year depending on climatic conditions, herbage mass, and plant physiology and stock requirements. Two grazing strategies that show potential are a short rest from grazing the pasture at the opening rains until the pasture has gained some leaf area, in years when the opening rains are late. The second strategy is to allow ryegrass to flower late in the season, preventing new vegetative growth, and perhaps allowing for tiller buds to be preserved in a dormant state over the summer. An extension of this strategy would be to delay grazing until after the ryegrass seed heads have matured and seed has shed from the inflorescences. This has the potential to increase ryegrass density in the following growing season from seedling recruitment. A number of research opportunities have been identified from this review for improving ryegrass persistence. One area would be to investigate the potential for using grazing management to allow late development of ryegrass seed heads to preserve tiller buds in a dormant state over the summer. Another option is to investigate the potential, and subsequently develop grazing procedures, to allow seed maturation and recruitment of ryegrass seedlings after the autumn rains.
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Wiet, Victoria. "Dickens’s Tableaux." Nineteenth-Century Literature 74, no. 2 (September 1, 2019): 167–98. http://dx.doi.org/10.1525/ncl.2019.74.2.167.
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Victoria Wiet, “Dickens’s Tableaux: Melodrama and Sexual Opacity in David Copperfield and Bleak House” (pp. 167–198) This essay examines the features and function of tableaux in two novels by Charles Dickens, David Copperfield (1850) and Bleak House (1853), in order to rethink the influence of melodramatic conventions on the form of narrative fiction, particularly the understanding of female sexuality that melodrama afforded novelists. Taking Dickens as an important example, literary critics have typically associated melodrama with ostentatious legibility, but recent scholarship on the theatrical tableau has illuminated the complex ways the melodramatic stage both produced and occluded revelation. Drawing on this work, I demonstrate that the adaptation of the tableau into the novel form increases the possibility of illegibility because readers necessarily rely on the narrator’s description and interpretation of the material world. In David Copperfield and Bleak House, this remediation has particularly significant consequences for the representation of sexually compromised women. By inadequately revealing the sexual histories of suspected “fallen women,” densely visual but opaque scenes featuring Annie Strong, Martha Endell, and Honoria Dedlock defer judgment on their characters, with Lady Dedlock’s protracted illegibility preventing her plot from culminating in a decisive narrative or moral conclusion. Because the narrators of both novels depict these female characters as deliberately making themselves illegible, the novel tableau becomes an important way for Dickens to dramatize the fallibility of the omniscient and quasi-omniscient narrators of realist fiction.
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Costin, Glenn P. "Bushfire: Retrofitting Rural and Urban Fringe Structures—Implications of Current Engineering Data." Energies 14, no. 12 (June 14, 2021): 3526. http://dx.doi.org/10.3390/en14123526.
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Since the 2009 Black Saturday bushfires in which 173 lives were lost, two-thirds of whom died in their homes, the question of what a home prepared for bushfire looks like has been repeatedly raised. The 2019/2020 fires saw us not much further advanced. This paper seeks to consolidate what is known about bushfire behavior, its influence upon structures, and, through this data, infer improved standards of practice for retrofitting rural and urban fringe homes. In particular, the prevention of ember and smoke incursion: the data suggesting the prior as the main mechanism of home destruction; the latter as high risk to sheltering occupant health. The article is framed around a comprehensive literature review, and the author’s own experiences and observations from fire impacted structures in Victoria’s northeast. The article’s import lies in demonstrating how embers and smoke may enter homes otherwise seen to be appropriately sealed prior to the fire’s approach. Included in the findings are developed hypotheses based on thermal expansion, pressure differentials and backdraft; offering defined paths towards future research. In addition, the work provides practical advice towards mitigating the identified issues using retrofit practices based upon the author’s practical experience as a tradesperson and building designer.
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Cameron, Adrian J. "The shelf space and strategic placement of healthy and discretionary foods in urban, urban-fringe and rural/non-metropolitan Australian supermarkets." Public Health Nutrition 21, no. 03 (November 16, 2017): 593–600. http://dx.doi.org/10.1017/s1368980017003019.
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AbstractObjectiveSupermarkets are a key influence on eating behaviours, but it is unknown if the promotion of food within stores varies on a geographic gradient from urban, to urban-fringe and non-metropolitan areas. The present study aimed to assess the shelf space and strategic placement of healthy and discretionary foods in each of urban, urban-fringe and non-metropolitan Australian supermarkets.Design/SettingIn-store audits were conducted in stores from one of the two major Australian supermarket chains in urban (n19), urban-fringe (n20) and non-metropolitan (n26) areas of Victoria. These audits examined selected food items (crisps/chips, chocolate, confectionery, soft drinks/sodas, fruits and vegetables) and measured the shelf space and the proportion of end-of-aisle and cash register displays containing these products. Store size was measured as the sum of aisle length. Differences in the supermarket food environment with respect to location were assessed, before and after adjustment for neighbourhood socio-economic position.ResultsThe strategic placement of discretionary foods was commonly observed in all supermarkets. Adjusting for store size (larger in urban-fringe and rural areas), urban stores had greater shelf space devoted to fruits and vegetables, and less checkouts with soft drinks, than urban-fringe and rural/non-metropolitan areas. Differences remained following adjustment for neighbourhood socio-economic position. No clear pattern was observed for end-of-aisle displays, or the placement of chocolate and confectionery at checkouts.ConclusionsThe shelf space of healthy and discretionary foods in urban-fringe and rural stores parallels the prevalence of overweight and obesity in these areas. Interventions in urban-fringe and rural stores targeting the shelf space of healthy foods and the placement of soft drinks at key displays may be useful obesity prevention initiatives.
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Averianova, Nina. "BATALISTICS IN FOREIGN AND UKRAINIAN ART HISTORY." Almanac of Ukrainian Studies, no. 29 (2021): 8–15. http://dx.doi.org/10.17721/2520-2626/2021.29.1.
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he author of the article shows that in art there have always been and are works of art that accurately reflect life conflict situations. They become an object of study for their further prevention and leveling. In turn, the artistic understanding of conflict phenomena complements, strengthens and facilitates the scientific analysis of the problems of the emergence of conflicts and the dynamics of their passage. In the visual arts, the works of the master depicting war, armed conflicts and confrontations are singled out in a separate - battle genre. Its origins can be found in many ancient cultures around the world. Draws attention to the fact that each of the stages in the development of culture leaves the next generations with examples of art with the fixation of external signs of the way of life. As well as social, national, spiritual, aesthetic issues of their time. Renaissance artists in battle compositions not only glorified the victories of commanders and conquerors and recorded important historical moments of military campaigns, but also filled these plots with new deep content. Artists of the 17th century openly addressed the realities of contemporary life, in particular, such dramatic phenomena as war and armed conflicts. In their works, they praised heroes, kings and generals, at the same time exposed robberies, looting and cruelty of soldiers. During the Napoleonic War, artists concentrated on conveying victories, heroism and glory in the war. They also showed his ugly sides: fear of hunger, cruelty, executions of prisoners, rape and human degradation. In the twentieth century. the methods and means of warfare have changed significantly, this clearly manifested itself during the First World War. Accordingly, the art of this period is the art of great upheavals, revolutions and world wars. Nowadays, both foreign and domestic artists, mainly work in a realistic style, they depict in detail military equipment, elements of combat, soldiers in dynamics. The point is that such paintings are replacing color photography, because today they are in significant demand. Proves that the plots of wars, battles and conflicts remain in demand in art, they continue to actively influence people's emotions and the formation of public opinion.
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Devi Artanti, Guspri, Fidesrinur, and Meyke Garzia. "Stunting and Factors Affecting Toddlers in Indonesia." JPUD - Jurnal Pendidikan Usia Dini 16, no. 1 (April 30, 2022): 172–85. http://dx.doi.org/10.21009/jpud.161.12.
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ABSTRACT: Asia is the second region after Africa to have the tallest prevalence of stunting in the world. Indonesia is one of the countries in Southeast Asia with the fifth highest prevalence of stunting in the world at 37%, or nearly 9 million children who experience stunting. This study aims to examine the factors that influence and risk the occurrence of stunting in children in Indonesia. The research method uses a type of qualitative research with a traditional literature review. This study found that stunting is influenced by several complex factors not only at the individual level but also at the family and community levels. A comprehensive synthesis of the available evidence on the determinants of stunting in children in Indonesia outlines who is most vulnerable to stunting, which interventions are successful, and what new research is needed to fill knowledge gaps.
Keywords: Indonesian toddlers, stunting factors
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Han, Jicheng, Xiangyu Zhu, Zihan Gao, Yan Xiao, Jinxin Zhang, Peng Wang, Jinbo Fang, et al. "Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection." Frontiers in Microbiology 13 (January 10, 2023). http://dx.doi.org/10.3389/fmicb.2022.1067725.
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Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.
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Pan, M., H. P. Yang, J. Jian, Y. Kuang, J. N. Xu, T. S. Li, X. Zhou, et al. "Association of meteorological factors with seasonal activity of influenza A subtypes and B lineages in subtropical western China." Epidemiology and Infection 147 (2019). http://dx.doi.org/10.1017/s0950268818003485.
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AbstractThe seasonality of individual influenza subtypes/lineages and the association of influenza epidemics with meteorological factors in the tropics/subtropics have not been well understood. The impact of the 2009 H1N1 pandemic on the prevalence of seasonal influenza virus remains to be explored. Using wavelet analysis, the periodicities of A/H3N2, seasonal A/H1N1, A/H1N1pdm09, Victoria and Yamagata were identified, respectively, in Panzhihua during 2006–2015. As a subtropical city in southwestern China, Panzhihua is the first industrial city in the upper reaches of the Yangtze River. The relationship between influenza epidemics and local climatic variables was examined based on regression models. The temporal distribution of influenza subtypes/lineages during the pre-pandemic (2006–2009), pandemic (2009) and post-pandemic (2010–2015) years was described and compared. A total of 6892 respiratory specimens were collected and 737 influenza viruses were isolated. A/H3N2 showed an annual cycle with a peak in summer–autumn, while A/H1N1pdm09, Victoria and Yamagata exhibited an annual cycle with a peak in winter–spring. Regression analyses demonstrated that relative humidity was positively associated with A/H3N2 activity while negatively associated with Victoria activity. Higher prevalence of A/H1N1pdm09 and Yamagata was driven by lower absolute humidity. The role of weather conditions in regulating influenza epidemics could be complicated since the diverse viral transmission modes and mechanism. Differences in seasonality and different associations with meteorological factors by influenza subtypes/lineages should be considered in epidemiological studies in the tropics/subtropics. The development of subtype- and lineage-specific prevention and control measures is of significant importance.
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Булгакова, В. А., Л. Р. Селимзянова, Т. Е. Привалова, and Д. А. Юсупова. "Immunisation of young children against influenza — evidence review." Лечащий врач, no. 10(25) (November 3, 2022). http://dx.doi.org/10.51793/os.2022.25.10.009.
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Грипп является высококонтагиозной вирусной инфекцией и представляет собой серьезное бремя, особенно для детей в возрасте до 5 лет из-за повышенного риска тяжелого течения заболевания и госпитализации. Связанная с гриппом детская смертность в доковидный период регистрировалась ежегодно. Самый высокий уровень смертности регулярно регистрировался среди детей младшего возраста и особенно детей в возрасте до 6 месяцев. Доказано, что вакцинопрофилактика гриппа у детей младшего возраста безопасна и эффективна. Вакцинация против гриппа детей раннего возраста не только защищает эту уязвимую возрастную группу, но и является важным способом снижения передачи гриппа другим лицам из группы риска, а также сокращает использование медицинских услуг, включая применение антибиотиков. Иммунизация против гриппа в текущих эпидемиологических условиях особенно актуальна, поскольку в продолжающуюся пандемию COVID-19 невозможно предсказать интенсивность и сроки предстоящего сезонного подъема гриппа. Для профилактики гриппа у детей применяется любая лицензированная противогриппозная вакцина, соответствующая показаниям, однако в современных условиях приоритетом в профилактике гриппа является использование четырехвалентных вакцин, обеспечивающих развитие наиболее устойчивого иммунного ответа против ключевых штаммов вирусов гриппа. В четырехвалентные противогриппозные вакцины включены два штамма гриппа В линий Yamagata и Victoria в дополнение к штаммам гриппа A (H1N1 и H3N2). Исследования показали, что иммунизация четырехвалентной вакциной, в том числе детей раннего возраста, хорошо переносится и эффективно защищает от любых циркулирующих и антигенно совпадающих штаммов вирусов гриппа. Четырехвалентная инактивированная гриппозная вакцина российского производства полного цикла для профилактики сезонного гриппа – первая в Российской Федерации квадривакцина, одобренная к применению для иммунизации от гриппа детей с 6 месяцев и беременных. Вакцина соответствует всем рекомендациям Всемирной организации здравоохранения по составу и количеству гемагглютинина штамма вируса гриппа – содержит по 15 мкг гемагглютинина вируса гриппа каждого штамма (А(N1N1), A(N3N2), B линия Yamagata, B линия Victoria); не содержит иммуномодуляторов, адъювантов и консервантов; соответствует критериям иммуногенности для инактивированных гриппозных вакцин, принятых в Евросоюзе и Российской Федерации. Influenza is a highly contagious viral infection and poses a serious burden, especially for children under 5 years of age due to an increased risk of severe illness and hospitalization. Influenza-related infant mortality during the pre-Covid period was reported annually. The highest mortality rate was regularly recorded among young children and especially children under the age of 6 months. Influenza vaccination in young children has been proven to be safe and effective. Influenza vaccination of young children not only protects this vulnerable age group, but is also an important way to reduce the transmission of influenza to others at risk, as well as reduce the use of healthcare services, including the use of antibiotics. Immunization against influenza in the current epidemiological conditions is especially relevant, since during the ongoing COVID-19 pandemic, it is impossible to predict the intensity and timing of the upcoming influenza seasonal rise. To prevent influenza in children, any licensed influenza vaccine that meets the indications is used, however, in modern conditions, the priority in influenza prevention is the use of quadrivalent vaccines that ensure the development of the most stable immune response against key strains of influenza viruses. Quadrivalent influenza vaccines include two influenza B strains of the Yamagata and Victoria B lines in addition to influenza A strains (H1N1 and H3N2). Studies have shown that immunization with the quadrivalent vaccine, including in young children, is well tolerated and effectively protects against any circulating and antigenically matched strains of influenza viruses. Russian-made quadrivalent inactivated full-cycle influenza vaccine for the prevention of seasonal influenza is the first quadrivaccine in the Russian Federation approved for use in influenza immunization of children from 6 months of age and pregnant women. The vaccine complies with all World Health Organization recommendations on the composition and amount of hemagglutinin of an influenza virus strain – it contains 15 μg of influenza virus hemagglutinin of each strain (А(N1N1), A(N3N2), B line Yamagata, B line Victoria); does not contain immunomodulators, adjuvants and preservatives; meets the immunogenicity criteria for inactivated influenza vaccines adopted in the European Union and the Russian Federation.
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Zheng, Luyan, Jinjin Qi, Jie Wu, and Min Zheng. "Changes in Influenza Activity and Circulating Subtypes During the COVID-19 Outbreak in China." Frontiers in Medicine 9 (March 22, 2022). http://dx.doi.org/10.3389/fmed.2022.829799.
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BackgroundNon-pharmaceutical interventions (NPIs) to mitigate COVID-19 can impact the circulation of influenza viruses. There is a need to describe the activity of influenza and its subtypes during the COVID-19 pandemic to aid in the development of influenza prevention and control measures in the next influenza season.MethodData from pathogenic surveillance performed by the Chinese National Influenza Center from January 2016 to August 2021 were extracted and stratified by type and subtype for northern China and southern China. The distribution of influenza activity and circulating subtypes were described during the COVID-19 pandemic, and data from 2016 to 2019 were used for comparisons.ResultsInfluenza activity declined rapidly and then rose slowly during the COVID-19 pandemic in China. The distribution of influenza subtypes changed from A-dominant to B/Victoria-dominant after the COVID-19 outbreak.DiscussionWhether the B/Yamagata lineage has disappeared from China deserves more attention in future virologic monitoring programs. The influenza vaccination campaign in the 2021–2022 season is an important means by which to reduce the proportion of susceptible people and limit the damage that potentially greater and earlier circulation of the virus could cause.
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Mao, Haiyan, Yi Sun, Yin Chen, Xiuyu Lou, Zhao Yu, Xinying Wang, Zheyuan Ding, et al. "Co-circulation of influenza A(H1N1), A(H3N2), B(Yamagata) and B(Victoria) during the 2017−2018 influenza season in Zhejiang Province, China." Epidemiology and Infection 148 (2020). http://dx.doi.org/10.1017/s0950268820000412.
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Abstract Influenza is a major human respiratory pathogen. Due to the high levels of influenza-like illness (ILI) in Zhejiang, China, the control and prevention of influenza was challenging during the 2017–2018 season. To identify the clinical spectrum of illness related to influenza and characterise the circulating influenza virus strains during this period, the characteristics of ILI were studied. Viral sequencing and phylogenetic analyses were conducted to investigate the virus types, substitutions at the amino acid level and phylogenetic relationships between sequences. This study has shown that the 2017/18 influenza season was characterised by the co-circulation of influenza A (H1N1) pdm09, A (H3N2) and B viruses (both Yamagata and Victoria lineage). From week 36 of 2017 to week 12 of 2018, ILI cases accounted for 5.58% of the total number of outpatient and emergency patient visits at the surveillance sites. Several amino acid substitutions were detected. Vaccination mismatch may be a potential reason for the high percentage of ILI. Furthermore, it is likely that multiple viral introductions played a role in the endemic co-circulation of influenza in Zhejiang, China. More detailed information regarding the molecular epidemiology of influenza should be included in long-term influenza surveillance.
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Lope, Dinah Jane, Haydar Demirhan, and Anil Dolgun. "Bayesian estimation of the effect of health inequality in disease detection." International Journal for Equity in Health 21, no. 1 (August 27, 2022). http://dx.doi.org/10.1186/s12939-022-01713-5.
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Abstract Background Measuring health inequality is essential to ensure that everyone has equal accessibility to health care. Studies in the past have continuously presented and showed areas or groups of people affected by various inequality in accessing the health resources and services to help improve this matter. Alongside, disease prevention is as important to minimise the disease burden and improve health and quality of life. These aspects are interlinked and greatly contributes to one’s health. Method In this study, the Gini coefficient and Lorenz curve are used to give an indication of the overall health inequality. The impact of this inequality in granular level is demonstrated using Bayesian estimation for disease detection. The Bayesian estimation used a two-component modelling approach that separates the case detection process and incidence rate using a mixed Poisson distribution while capturing underlying spatio-temporal characteristics. Bayesian model averaging is used in conjunction with the two-component modelling approach to improve the accuracy of estimates by incorporating many candidate models into the analysis instead of using fixed component models. This method is applied to an infectious disease, influenza, in Victoria, Australia between 2013 and 2016 and the corresponding primary health care of the state. Result There is a relatively equal distribution of health resources and services pertaining to general practitioners (GP) and GP clinics in Victoria, Australia. Roughly 80 percent of the population shares 70 percent of the number of GPs and GP clinics. The Bayesian estimation with model averaging revealed that access difficulty to health services impacts both case detection probability and incidence rate. Minimal differences are recorded in the observed and estimated incidence of influenza cases considering social deprivation factors. In most years, areas in Victoria’s southwest and eastern parts have potential under-reported cases consistent with their relatively lower number of GP or GP clinics. Conclusion The Bayesian model estimated a slight discrepancy between the estimated incidence and the observed cases of influenza in Victoria, Australia in 2013-2016 period. This is consistent with the relatively equal health resources and services in the state. This finding is beneficial in determining areas with potential under-reported cases and under-served health care. The proposed approach in this study provides insight into the impact of health inequality in disease detection without requiring costly and time-extensive surveys and relying mainly on the data at hand. Furthermore, the application of Bayesian model averaging provided a flexible modelling framework that allows covariates to move between case detection and incidence models.
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Izurieta, Hector S., Michael Lu, Jeffrey Kelman, Yun Lu, Arnstein Lindaas, Julie Loc, Douglas Pratt, et al. "Comparative effectiveness of influenza vaccines among U.S. Medicare beneficiaries ages 65 years and older during the 2019-20 season." Clinical Infectious Diseases, November 19, 2020. http://dx.doi.org/10.1093/cid/ciaa1727.
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Abstract Background Around 50,000 influenza-associated deaths occur annually in the U.S., overwhelmingly among individuals ages >65 years. Although vaccination is the primary prevention tool, investigations have shown low vaccine effectiveness (VE) in recent years, particularly among the elderly. We analyzed the relative VE (RVE) of all influenza vaccines among Medicare beneficiaries ages >65 years to prevent influenza hospital encounters during the 2019-20 season. Methods Retrospective cohort study using Poisson regression and inverse probability of treatment weighting (IPTW). Exposures included egg-based high-dose trivalent (HD-IIV3), egg-based adjuvanted trivalent (aIIV3), egg-based standard dose (SD) quadrivalent (IIV4), cell-based SD quadrivalent (cIIV4), and recombinant quadrivalent (RIV4) influenza vaccines. Results We studied 12.7 million vaccinated beneficiaries. Following IPTW, cohorts were well balanced for all covariates and health-seeking behavior indicators. In the adjusted analysis, RIV4 (RVE 13.3%, 95% CI 7.4%, 18.9%), aIIV3 (RVE 8.2%, 95% CI 4.2%, 12.0%), and HD-IIV3 (RVE 6.8%, 95% CI 3.3%, 10.1%) were significantly more effective in preventing hospital encounters than the reference egg-based SD IIV4, while cIIV4 was not significantly more effective than IIV4 (RVE 2.8%, 95% CI -2.8%, 8.2%). Our results were consistent across all analyses. Conclusions In this influenza B-Victoria and A(H1N1)-dominated season, RIV4 was moderately more effective than other vaccines, while the HD-IIV3 and aIIV3 were more effective than the IIV4 vaccines, highlighting the contributions of antigen amount and adjuvant use to VE. Egg adaptation likely did not substantially affect our RVE evaluation. Our findings, specific to the 2019-20 season, should be evaluated in other studies using virological case confirmation.
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Banerjee, Dithi, Neena Kanwar, Ferdaus Hassan, Cynthia Essmyer, and Rangaraj Selvarangan. "Comparison of Six Sample-to-Answer Influenza A/B and Respiratory Syncytial Virus Nucleic Acid Amplification Assays Using Respiratory Specimens from Children." Journal of Clinical Microbiology 56, no. 11 (September 5, 2018). http://dx.doi.org/10.1128/jcm.00930-18.
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ABSTRACT The rapid and accurate detection of influenza A virus (FluA), influenza B virus (FluB), and respiratory syncytial virus (RSV) improves patient care. Sample-to-answer (STA) platforms based on nucleic acid amplification and detection of these viruses are simple, automated, and accurate. We compared six such platforms for the detection of FluA, FluB, and RSV: Cepheid GeneXpert Xpress Flu/RSV (Xpert), Hologic Panther Fusion Flu A/B/RSV (Fusion), Cobas influenza A/B & RSV (Liat), Luminex Aries Flu A/B & RSV (Aries), BioFire FilmArray respiratory panel (RP), and Diasorin Simplexa Flu A/B & RSV (Simplexa). Nasopharyngeal (NP) swab specimens (n = 225) from children previously tested by RP were assessed on these platforms. The results were compared to those of the Centers for Disease Control and Prevention (CDC)-developed real-time reverse transcription-PCR (rRT-PCR) assay for influenza A/B viruses and RSV. Subtyping for FluA and FluB was performed for discrepant analysis where applicable. The percent sensitivities/specificities for FluA detection were 100/100 (Fusion), 98.6/99.3 (Xpert), 100/100 (Liat), 98.6/100 (Aries), 98.6/100 (Simplexa), and 100/100 (RP). The percent sensitivities/specificities for FluB detection were 100/100 (Fusion), 97.9/99.4 (Xpert), 97.9/98.3 (Liat), 93.7/99.4 (Aries), 85.4/99.4 (Simplexa), and 95.8/97.7 (RP); and those for RSV detection were 98.1/99.4 (Xpert), 98.1/99.4 (Liat), 96.3/100 (Fusion), 94.4/100 (Aries), 87/94.4 (Simplexa), and 94.4/100 (RP). The 75 strains confirmed to be FluA included 29 pH1N1, 39 H3N2, 4 sH1N1, and 3 untyped strains. The 48 strains confirmed to be FluB included 33 strains of the Yamagata lineage, 13 of the Victoria lineage, 1 of both the Yamagata and Victoria lineages, and 1 of an unknown lineage. All six STA platforms demonstrated >95% sensitivity for FluA detection, while three platforms (Fusion, Xpert, and Liat) demonstrated >95% sensitivity for FluB and RSV detection.