Academic literature on the topic 'Inflammatory component'
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Journal articles on the topic "Inflammatory component":
Heymann, Warren R. "The inflammatory component of androgenetic alopecia." Journal of the American Academy of Dermatology 86, no. 2 (February 2022): 301–2. http://dx.doi.org/10.1016/j.jaad.2021.11.013.
Pantanowitz, Liron, Ashlee V. Moses, and Bruce J. Dezube. "The inflammatory component of Kaposi sarcoma." Experimental and Molecular Pathology 87, no. 2 (October 2009): 163–65. http://dx.doi.org/10.1016/j.yexmp.2009.07.001.
JAYSON, M. I. V. "THE INFLAMMATORY COMPONENT OF MECHANICAL BACK PROBLEMS." Rheumatology 25, no. 2 (1986): 210–13. http://dx.doi.org/10.1093/rheumatology/25.2.210.
Abell, E., and A. M. Kligman. "The Inflammatory Component of Male Pattern Alopecia." American Journal of Dermatopathology 11, no. 3 (June 1989): 287. http://dx.doi.org/10.1097/00000372-198906000-00023.
Nakamura, M., and S. H. Ferreira. "A peripheral sympathetic component in inflammatory hyperalgesia." European Journal of Pharmacology 135, no. 2 (March 1987): 145–53. http://dx.doi.org/10.1016/0014-2999(87)90606-6.
Prokop, Laurel Derks. "Isotretinoin: Possible Component Cause of Inflammatory Bowel Disease." American Journal of Gastroenterology 94, no. 9 (September 1999): 2568. http://dx.doi.org/10.1111/j.1572-0241.1999.02568.x.
Prokop, L. "Isotretinoin: Possible component cause of inflammatory bowel disease." American Journal of Gastroenterology 94, no. 9 (September 1999): 2568. http://dx.doi.org/10.1016/s0002-9270(99)00459-1.
AL-JANABI, M. A., K. SOLANKI, M. CRITCHLEY, M. L. SMITH, K. E. BRITTON, and E. C. HUSKISSON. "Radioleucoscintigraphy in osteoarthritis. Is there an inflammatory component?" Nuclear Medicine Communications 13, no. 10 (October 1992): 706–12. http://dx.doi.org/10.1097/00006231-199210000-00002.
AL-JANABI, M. A., K. SOLANKI, M. CRITCHLEY, M. L. SMITH, K. E. BRITTON, and E. C. HUSKISSON. "Radioleucoscintigraphy in osteoarthritis. Is there an inflammatory component?" Nuclear Medicine Communications 13, no. 10 (October 1992): 706–12. http://dx.doi.org/10.1097/00006231-199213100-00002.
Szilagyi, Andrew. "Use of Prebiotics for Inflammatory Bowel Disease." Canadian Journal of Gastroenterology 19, no. 8 (2005): 505–10. http://dx.doi.org/10.1155/2005/415698.
Dissertations / Theses on the topic "Inflammatory component":
Coltman, Clare. "Oncastatin M is a key component of the inflammatory environment in multiple sclerosis." Thesis, University of the West of England, Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431302.
McElhanon, Kevin Edward. "Autoantibodies Targeting a Critical Component of Sarcolemma Resealing Contribute to Idiopathic Inflammatory Myopathy Pathophysiology." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1585998781690227.
Cotena, A. "The long pentraxin 3 : a key component of innate immunity, modulates the inflammatory response to non self and self ligands." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/64593.
Goshovska, A. V. "Features of the vascular component at the stage of the placental complex formation against a background of inflammatory diseases of the female genital organs." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18715.
Pokrzywa, Malgorzata. "A Drosophila Disease-Model for Transthyretin-associated Amyloidosis." Doctoral thesis, Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1677.
Martineau, Sabrina. "Etude des mécanismes moléculaires de l'épidermolyse bulleuse simple à partir de cellules souches humaines induites à la pluripotence." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ020.
Epidermolysis bullosa simplex (EBS) is a skin disorder caused mainly by dominant mutations in genes coding for keratin 5 (KRT5) or 14 (KRT14) genes. It is characterized by the presence of blisters caused by epidermal detachment, and by other complications such as cutaneous inflammation. From a genetic point of view, the mutations will alter the assembly of the keratin intermediate filament network in basal keratinocytes of the epidermis, leading to cell cytolysis and the formation of intra-epidermal blisters. Currently no effective therapeutic approach it is available. Understanding of the disease and the development of therapies have been hampered by the lack and limitations of relevant human cell and mouse models.So, the general aim of my thesis was to exploit the properties of human induced pluripotent stem cells (hiPSc) to modelling EBS. For this purpose, we generate hiPSc-derived keratinocytes from EBS patients carrying KRT5 mutations (Ker-EBS), and from healthy patients (Ker-WT). Comparison of Ker-EBS and Ker-WT enabled to show that Ker-EBS recapitulates the main phenotypes associated with EBS, namely decreased cell proliferation, increased cell migration, altered signalling pathways (ERK and JNK), as well as aggregates of intermediate keratin filaments in the cytoplasm, as observed in primary EBS keratinocytes. These results demonstrate that our hiPSc-derived cell model is relevant for study EBS.In order to identify new molecular mechanisms, a trancriptomic analysis comparing Ker-EBS with Ker-WT revealed 138 deregulated genes, revealing an enrichment in processes linked to the extracellular matrix, DNA packaging and the inflammatory response. As the inflammatory component in EBS has been poorly described, my next step was to study the pro-inflammatory cytokine phenotype. Thus, we were able to demonstrate increased expression of IL-1α, IL-1β, IL-6, IL-8 (CXCL8), CXCL5, CXCL10, CXCL11, CCL5 in Ker-EBS, at RNA level under basal or IFNy-stimulated conditions to mimic a pro-inflammatory context. Only the chemokines CXCL10 and CXCL11 are secreted at high concentrations in the culture supernatants of stimulated and unstimulated Ker-EBS, demonstrating the involvement of these cytokines in EBS.In parallel, in order to avoid biases due to genetic background, gender, patient age and epigenetics, we generated an isogenic Ker-EBS line (corrected Ker-EBS) using the CRISPR-Cas9 technique. We were thus able to demonstrate that the corrected Ker-EBS line showed a restoration of the expression level of the pro-inflammatory cytokines mentioned above, to a level close to that of Ker-WT, confirming a direct link between mutations in the KRT5 gene and the pro-inflammatory signature.In conclusion, our new cellular model enabled us to reproduce the pathological phenotypes known in the literature, and to demonstrate deregulation of pro-inflammatory cytokine expression in EBS, notably CXCL10 and CXCL11. Taken together, these results make this model a relevant tool to allow a better understanding of the molecular mechanisms associated with the pathology, particularly the inflammatory component, paving the way for new therapeutic approaches
Wilson, Martin Robert. "Pulmonary inflammatory effects of environmental and surrogate environmental particulates and their components." Thesis, Edinburgh Napier University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270524.
Chowdhury, Pratiti Home. "PM2.5 components and respiratory allergy: a series of in vitro studies focusing Asian cities." Kyoto University, 2017. http://hdl.handle.net/2433/227613.
Yamamoto, Takayuki. "Studies on the safety of food and feed, and on the effects of plant derivedanti-inflammatory components." Kyoto University, 2016. http://hdl.handle.net/2433/215596.
0048
新制・課程博士
博士(農学)
甲第19770号
農博第2166号
新制||農||1040(附属図書館)
学位論文||H28||N4986(農学部図書室)
32806
京都大学大学院農学研究科食品生物科学専攻
(主査)教授 河田 照雄, 教授 保川 清, 教授 橋本 渉
学位規則第4条第1項該当
MILIA, CHIARA. "Evaluation of pain components in an animal model of chronic inflammatory pain: a study towards new therapeutics." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199051.
Chronic pain is a disabling and long-lasting cross-pathology condition, currently treated with mostly opioid drugs, which are leading to severe side-effects such as constipation, respiratory depression, addiction and tolerance. I2 ligands showed analgesic properties and to contrast tolerance development in co-administration with opioids. CR4056, a novel I2-agonist drug, has proved to have analgesic efficacy in several animal models of chronic pain, in which, moreover, a strong synergistic effect with morphine has been observed. The aim of my study was therefore to examine the interaction between morphine and CR4056 regarding opioid tolerance, and to elucidate their pharmacological interaction. To this scope, I assessed behavioral effects of the synergy between CR4056 and morphine on tolerance development and expression in the CFA model of chronic pain. Putative CR4056 action on opioid-induced side effects and spinal microgliosis were also assessed. It is known, in fact, that spinal microglia have an important role in chronic pain and opioid-induced tolerance, since, in these conditions, a sustained microglia activation has been observed, linked to the release of pro-inflammatory factors. Lastly, we aimed to better understand CR4056-morphine synergy at molecular level. In fact, it has been shown that DRG neurons of animal models of chronic pain display higher activation of TRPV1 receptor, depending on PKCε phosphorylation and translocation to cell membrane. Moreover, there is evidence that several analgesics are able to inhibit PKCε phosphorylation in cultured sensory neurons. Interestingly, in preliminary unpublished data, we observed that morphine and CR4056 can contrast PKCε translocation induced by inflammatory factors in primary rat DRG cultures. Therefore, in this work we aimed to elucidate the effects of acute administrations of morphine or CR4056 in ex vivo DRG from CFA-treated rats, by quantification of PKCε phosphorylation and TRPV1 expression, and in the spinal cord, by evaluation of microgliosis. My results demonstrated that CFA-induced inflammation triggered mechanical hyperalgesia, acutely counteracted by morphine or CR4056. Combined administration of morphine with CR4056 caused a dose-dependent prevention of morphine tolerance, which was established in the morphine alone treated group, in a short (4 days) and in a long paradigm (14 days). Moreover, when CR4056 was co-administered with morphine in already tolerant rats, it was able to improve morphine analgesic activity. In the same animals, spinal microglia activation was augmented in CFA-injected rats, either vehicle- or morphine-treated, but not in the group with CR4056-morphine combined administration. Besides, the synergy was not accompanied by an additive modulation of opioid-induced constipation. In L4-L5 DRG of CFA-injected rats we found a significant increase in the phosphorylation of PKC-ε, as well as in the colocalization between PKC-ε and VR1, compared to sham animals and to acutely treated animals (with CR4056 or morphine). In the same animals, activated microglial cells were significantly increased in CFA vehicle-treated animals compared to control and CR4056-treated animals, but not to morphine-treated rats. In conclusion, these data suggest that CR4056 seems to be a valid drug to prevent and rescue opioid tolerance without exacerbate side-effects. Moreover, in vitro data on CR4056 and morphine synergistic mechanism on PKCε were validated in ex vivo DRG from CFA-treated rats. Further studies will be needed to elucidate effects of combined treatment on DRG and spinal cord in order to understand the mechanism of CR4056 and opioids synergy.
Books on the topic "Inflammatory component":
Zhou, Jiaju. Zhong yao kang yan huo xing cheng fen: Anti-inflammatory active components in TCM. 8th ed. Beijing: Ke xue chu ban she, 2012.
Klingenberg, Roland, and Ulf Müller-Ladner. Mechanisms of inflammation. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0270.
Freer, Phoebe E. Skin Lesions. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0050.
Machado, Pedro M. Inclusion body myositis. Edited by Hector Chinoy and Robert Cooper. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198754121.003.0011.
Laffey, John G., and Brian P. Kavanagh. Hypercapnia in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0086.
Hahn, Robert G. Intravenous fluids in anaesthetic practice. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0020.
Lalvani, Ajit, and Katrina Pollock. Defences against infection. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0303.
Eisen, Andrew. Motor neurone disease. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199658602.003.0009.
Patel, Mayur B., and Pratik P. Pandharipande. Analgesics in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0043.
Takeshita, Junko, and Joel M. Gelfand. Epidemiology of psoriasis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0002.
Book chapters on the topic "Inflammatory component":
Ferrari, C. C., and F. J. Pitossi. "The Inflammatory Component of Neurodegenerative Diseases." In Handbook of Neurochemistry and Molecular Neurobiology, 395–406. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-30398-7_18.
Olofsson, Peter, Malin Hultqvist, Lars I. Hellgren, and Rikard Holmdahl. "Phytol: A Chlorophyll Component with Anti-inflammatory and Metabolic Properties." In Recent Advances in Redox Active Plant and Microbial Products, 345–59. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8953-0_13.
Wilson, David J., and Marcelo de Abreu. "Spine Degeneration and Inflammation." In IDKD Springer Series, 197–213. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71281-5_14.
Knop, Nadja, and Erich Knop. "Regulation of the Inflammatory Component in Chronic Dry Eye Disease by the Eye-Associated Lymphoid Tissue (EALT)." In Research Projects in Dry Eye Syndrome, 23–39. Basel: KARGER, 2010. http://dx.doi.org/10.1159/000315017.
Grangette, Corinne. "Probiotics and Inflammatory Immune Responses." In Dietary Components and Immune Function, 591–610. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-061-8_32.
Dziarski, R., A. J. Ulmer, and D. Gupta. "Interactions of CD14 with Components of Gram-Positive Bacteria." In CD14 in the Inflammatory Response, 83–107. Basel: KARGER, 1999. http://dx.doi.org/10.1159/000058761.
Schwartz, Colin J., Eugene A. Sprague, Anthony J. Valente, Jim L. Kelley, Ellen H. Edwards, and C. Alan Suenram. "Inflammatory Components of the Human Atherosclerotic Plaque." In Pathobiology of the Human Atherosclerotic Plaque, 107–20. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4612-3326-8_7.
Foligné, Benoit, Joëlle Dewulf, Bruno Pot, Catherine Daniel, Michel Simonet, Sabine Poiret, Michaël Marceau, and Rodrigue Dessein. "Therapeutic Potential of Yersinia Anti-Inflammatory Components." In Advances In Experimental Medicine And Biology, 361–66. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-72124-8_33.
Cao, Heping. "Cinnamon and Immune Actions: Potential Role in Tristetraprolin-Mediated Inflammatory Diseases." In Dietary Components and Immune Function, 553–65. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-061-8_30.
Panchal, Sunil K., and Lindsay Brown. "Anti-inflammatory Components from Functional Foods for Obesity." In Pathophysiology of Obesity-Induced Health Complications, 285–303. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-35358-2_17.
Conference papers on the topic "Inflammatory component":
Piqué-Borràs, M.-R., M. Jaklin, J. Röhrl, A. Ammendola, and G. Künstle. "Mechanisms of action of a multi-component herbal preparation in inflammatory bowel disease: anti-inflammatory activity." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759299.
Coimbra, Robson Carlos, Cristiane Carla Muniz, Juliana Silva de Oliveira, and Alexandre dos Santos Gomes. "Thermography as an aid in preventing injuries in football: Presentation of a possible curricular component in imaging courses." In V Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvmulti2024-160.
Monahan, R. C., L. Beaart- van de Voorde, C. Magro-Checa, T. Huizinga, H. Middelkoop, M. van Buchem, I. Ronen, A. Kaptein, and G. Steup-Beekman. "FRI0383 Changes in white matter microstructure correlate with sf-36 mental component subscore in inflammatory npsle." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.6249.
Cheng, WanYun, Jenna Currier, Philip A. Bromberg, Robert Silbajoris, and James M. Samet. "Exposure To An Organic PM Component Induces Inflammatory And Adaptive Gene Expression Through Mitochondrial Oxidative Stress." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3232.
Lussier, A. L., E. Yu, and P. Lindholm. "Is There an Inflammatory Component Present in Immersion Pulmonary Edema? Evidence From Increased Fractional Exhaled Nitric Oxide (FeNO)." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5505.
V.S., Ponamarev, and Atikov A.S. "he use of the complex drug "Penbex" in the treatment of idiopathic pathology of the upper respiratory tract of horses." In SPbVetScience. FSBEI HE St. Petersburg SUVM, 2023. http://dx.doi.org/10.52419/3006-2022-7-61-69.
Pidaparti, Ramana M., and Kevin R. Ward. "Airway Inflammation Induced by Mechanical Ventilation Through Multiscale Modeling." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80174.
Schaub, R. G., C. J. Dunn, D. E. Tracey, W. E. Fleming, and M. D. Burdick. "THROMBOTIC AND INFLAMMATORY CHANGES IN ENDOTHELIAL CELLS INCUBATED WITH LEUKOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642860.
Pirogov, Aleksey, Anna Prikhodko, Evgeniya Afanas'eva, and Yuliy Perelman. "COMPARATIVE ASSESSMENT OF AIRWAY CELLULAR INFLAMMATION IN PATIENTS WITH BRONCHIAL ASTHMA IN RESPONSE TO HYPOSMOLAR AND COLD STIMULES." In XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9c45b256.10926397.
Tayyem, Reema. "Dietary Patterns and Risk of Inflammatory Bowel Disease: Findings from a Case-Control Study." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0082.
Reports on the topic "Inflammatory component":
Casebere, Kelsey R., Michael G. Kaiser, and Susan J. Lamont. Bacterial Component Induced Inflammatory Response in Roosters from Diverse Genetic Lines. Ames (Iowa): Iowa State University, January 2015. http://dx.doi.org/10.31274/ans_air-180814-1319.
Neodo, Anna, Fiona Augsburger, Jan Waskowski, Joerg C. Schefold, and Thibaud Spinetti. Monocytic HLA-DR expression and clinical outcomes in adult ICU patients with sepsis – a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0119.
Shpigel, Nahum Y., Ynte Schukken, and Ilan Rosenshine. Identification of genes involved in virulence of Escherichia coli mastitis by signature tagged mutagenesis. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7699853.bard.