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1

L, Brusch John, ed. Infective endocarditis. New York: Oxford University Press, 1996.

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2

Habib, Gilbert, ed. Infective Endocarditis. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32432-6.

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3

Siniawski, Henryk. Active Infective Aortic Valve Endocarditis with Infection Extension. Heidelberg: Steinkopff, 2006. http://dx.doi.org/10.1007/3-7985-1629-4.

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4

L, Dominguez Claudia, and Ramos Alba M, eds. Bacterial endocarditis: Etiology, pathogenesis, and interventions. New York: Nova Science Publishers, 2008.

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5

An atlas of infective endocarditis: Diagnosis and management. Pearl River, N.Y., USA: Parthenon Pub. Group, 1995.

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6

Endocarditis essentials. Sudbury, Mass: Jones & Bartlett Learning, 2011.

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7

Steven, Bolling, and Vlessis Angelo A, eds. Endocarditis: A multidisciplinary approach to modern treatment. Armonk, NY: Futura, 1999.

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8

Shorrock, Patricia Joan. Surface properties of enterococcus faecalis in relation to infective endocarditis. Birmingham: Aston University. Department of Pharmaceutical Sciences, 1990.

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9

Mitral valve prolapse: Benign syndrome? [Barrie, Ont.]: Wellington House Press, 1990.

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10

Infective Endocarditis. Academic Press, 1988.

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11

Endre, Bodnar, and Horstkotte D, eds. Infective endocarditis. London: ICR Publishers, 1991.

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12

Habib, Gilbert, and Franck Thuny. Infective endocarditis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0018.

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Echocardiography plays a key role in the assessment of infective endocarditis. It is useful for the diagnosis of endocarditis, the assessment of severity of the disease, the prediction of short-term and long-term prognosis, the prediction of embolic risk, the management of the complications of endocarditis, and the follow-up of patients under specific antibiotic therapy.The ‘Guidelines on the prevention, diagnosis, and treatment of infective endocarditis’ of the European Society of Cardiology and the ‘Recommendations for the practice of echocardiography in infective endocarditis’ of the European Association for Echocardiography recently underlined the value and limitations of echocardiography in infective endocarditis, and gave clear recommendations for the optimal use of both transthoracic echocardiography and transoesophageal echocardiography in infective endocarditis.
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13

Ramrakha, Punit, and Jonathan Hill, eds. Infective endocarditis. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199643219.003.0004.

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Presentation of endocarditis 188Diagnosis of endocarditis 190Investigation of endocarditis 192Antibiotics in endocarditis 194Stopping endocarditis treatment 196Culture-negative endocarditis 198Prosthetic valve endocarditis 200Surgery for endocarditis 202Endocarditis prophylaxis 206Outpatient review 208• Highly variable presentation—depends on intracardiac pathology, virulence of organism, and extracardiac involvement....
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14

Kocher, Ajar. Infective Endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0018.

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Infectious endocarditis (IE) is an infection of the heart’s innermost layer, the endothelium. Most cases require a predisposing injury to the endocardium to serve as a nidus for thrombus development, which in turn acts as nidus for bloodstream microorganisms. These intravascular microorganisms can result from dental and other invasive procedures, infected vascular catheters, and skin lesions. However, most episodes of IE result from transient bacteremia during menial tasks, such as chewing and brushing one’s teeth. Blood cultures and echocardiograms are critical for IE diagnosis. Transesophageal echocardiogram (TEE) is the preferred diagnostic tool for prosthetic valve endocarditis and cardiovascular implantable electronic device (CIED) infections. IE complicated by heart failure and cerebral emboli has high rates of morbidity and mortality. Large vegetation, mobile lesions, mitral valve vegetation, and infection by S. aureus and fungi are more likely to result in embolic phenomena. Indications for surgery include severe heart failure, persistent infection, fungal infection, heart block, and abscess formation.
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15

Katritsis, Demosthenes G., Bernard J. Gersh, and A. John Camm. Infective endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199685288.003.1810_update_003.

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16

1931-, Kaye Donald, ed. Infective endocarditis. 2nd ed. New York: Raven Press, 1992.

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17

Brusch, John L. Infective Endocarditis. CRC Press, 2007. http://dx.doi.org/10.3109/9781420019834.

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18

Magnusson, Peter, and Robin Razmi, eds. Infective Endocarditis. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.78176.

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19

Wilson, John W., and Lynn L. Estes. Infective Endocarditis Prophylaxis. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0082.

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The guidelines for the prevention of infective endocarditis (IE) issued by the American Heart Association underwent a major revision in 2007. Key changes include the following: • Dental procedures have been found to be associated with a small number of cases of IE. Thus, even if prophylaxis was 100% effective, it would prevent only an extremely small number of cases....
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20

Siniawski, Henryk. Active Infective Aortic Valve Endocarditis with Infection Extension. Springer, 2008.

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21

Kilic, Arman. Infective Endocarditis: A Multidisciplinary Approach. Elsevier Science & Technology, 2021.

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22

Ramsdale, David R. Color Atlas of Infective Endocarditis. Springer, 2007.

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23

Ramsdale, David R. Color Atlas of Infective Endocarditis. Springer, 2005.

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24

Grossman, Jonah, Tanzila Shams, and Cathy Sila. Neurological Complications of Infective Endocarditis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0167.

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Infective endocarditis is the fourth leading cause of life-threatening infections, accounting for 40,000 annual U.S. hospital admissions. Due to decline in rheumatic heart disease, a shift in causative organisms from viridans streptococci to S. aureus, Group D Streptococcus, and multidrug-resistant species has been observed. The spectrum of neurological complications ranges widely from cerebrovascular pathologies-including septic embolization, mycotic aneurysms, and intracerebral hemorrhages-to seizures, meningitis, cerebritis, and abscess. Transthoracic echocardiogram remains the standard for initial investigation whereas CT scans, MRI with DWI sequence, and cerebral angiograms are useful for exploring neurological complications. Antibiotic regimens, tailored to culprit organisms, should be initiated early after obtaining blood cultures and continued for 4 to 6 weeks. Antithrombotic treatment may pose increased risk for intracerebral hemorrhage, even in the absence of mycotic aneurysms (MA). Unruptured MA must be treated according to risk of rupture and overall health of the patient. MAs either at risk or previously ruptured should be secured by neurosurgical or endovascular means. Early cardiac surgery is a viable option for prevention of septic embolization for high-risk cardiac diseases such as perivalvular abscess and infection with resistant organisms, but may increase mortality rates for those with decompensated heart failure.
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25

Wilson, John W., and Lynn L. Estes. Infective Endocarditis: Diagnosis and Treatment. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0070.

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• Viridans streptococci•Staphylococcus aureus• Enterococci• HACEK organisms• Same as native valves, plus• Coagulase-negative staphylococci• Fungi• Gram-negative rods (early postoperative period)The diagnosis of infective endocarditis (IE) rests on demonstrated evidence of cardiac involvement and persistent bacteremia due to microorganisms that typically cause endocarditis. Establishing a microbiologic diagnosis is critical to therapeutic decisions. Every effort should be made to identify the causative organism....
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26

Kilic, Arman. Infective Endocarditis: A Multidisciplinary Approach. Elsevier Science & Technology Books, 2021.

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27

Color Atlas of Infective Endocarditis. London: Springer London, 2005. http://dx.doi.org/10.1007/1-84628-136-9.

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28

Kerrigan, Steve W., ed. Recent Advances in Infective Endocarditis. InTech, 2013. http://dx.doi.org/10.5772/46221.

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29

(Editor), Kwan-Leung Chan, and John Embil (Editor), eds. Endocarditis: Diagnosis and Management. Springer, 2006.

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30

Chan, Kwan-Leung, and John M. Embil. Endocarditis: Diagnosis and Management. Springer London, Limited, 2016.

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31

Chan, Kwan-Leung, and John M. Embil. Endocarditis: Diagnosis and Management. Springer, 2006.

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32

Chan, Kwan-Leung, and John M. Embil. Endocarditis: Diagnosis and Management. Springer London, Limited, 2014.

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33

Habib, Gilbert, Franck Thuny, Guy Van Camp, and Simon Matskeplishvili. Endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0041.

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Echocardiography plays a key role in the assessment of infective endocarditis (IE). It is useful both for the diagnosis of endocarditis, the assessment of the severity of the disease, the prediction of short-term and long-term prognosis, the prediction of embolic risk, the management of the complications of endocarditis, and the follow-up of patients under specific antibiotic therapy. The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology and the ‘Recommendations for the practice of echocardiography in infective endocarditis’ of the European Association for Echocardiography have underlined the value and limitations of echocardiography in IE, and gave clear recommendations for the optimal use of both transthoracic and transoesophageal echocardiography in IE. New data in the field of echocardiography in IE includes more extensive use of three-dimensional transoesophageal echocardiography, inclusion of other imaging techniques, and new important publications in the field of the prediction of embolic risk by echocardiography.
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34

Freedman, Lawrence R. Infective Endocarditis and Other Intravascular Infections. Springer London, Limited, 2012.

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35

Freedman, Lawrence R. Infective Endocarditis and Other Intravascular Infections. Springer, 2012.

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36

Habib, Gilbert. Infective Endocarditis: Epidemiology, Diagnosis, Imaging, Therapy, and Prevention. Springer, 2018.

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37

Habib, Gilbert. Infective Endocarditis: Epidemiology, Diagnosis, Imaging, Therapy, and Prevention. Springer, 2016.

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38

Habib, Gilbert. Infective Endocarditis: Epidemiology, Diagnosis, Imaging, Therapy, and Prevention. Springer London, Limited, 2016.

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39

1939-, Magilligan Donald J., and Quinn Edward L, eds. Endocarditis: Medical and surgical management. New York: M. Dekker, 1986.

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40

Siniawski, Henryk. Active Infective Aortic Valve Endocarditis with Infection Extension: Clinical Features, Perioperative Echocardiographic Findings and Results of Surgical Treatment. Springer London, Limited, 2006.

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41

Ward, C. An Atlas of Infective Endocarditis: Diagnosis and Management (Encyclopedia of Visual Medicine). Informa Healthcare, 1996.

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42

Active Infective Aortic Valve Endocarditis with Infection Extension: Clinical Features, Perioperative Echocardiographic Findings and Results of Surgical ... in der Herz-, Thorax- und Gefäßchirurgie). Steinkopff-Verlag Darmstadt, 2006.

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43

Thuny, Franck, and Didier Raoult. Pathophysiology and causes of endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0160.

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Endocarditis is defined as an inflammation of the endocardial surface of the heart. This may include heart valves, mural endocardium or the endocardium that covers implanted material, such as prosthetic valves, pacemaker/defibrillator leads and catheters. Infective and non-infective-related causes must be distinguished. In most cases, the inflammation is related to a bacterial or fungal infection with oral streptococci, group D streptococci, staphylococci and enterococci accounting for 85% of episodes. Infective endocarditis (IE) is a serious disease with an incidence ranging from 30 to 100 episodes/million patient-years. From various portals of entry (e.g. oral, digestive, cutaneous) and a subsequent bacteraemia, pathogens can adhere and colonize intracardiac foreign material or onto previously damaged endocardium due to numerous complex processes based on a unique host–pathogen interaction. Rarely, endocarditis can be related to non-infective causes, such as immunological or neoplastic. Mortality is high, with more than one-third dying within a year of diagnosis from complications such as acute heart failure or emboli. This disease still remains a diagnostic challenge with many cases being identified and subsequently treated too late. Diagnosis of IE usually relies on the association between an infectious syndrome and recent endocardial involvement. Blood cultures and echocardiography are the main diagnostic procedures, but are negative in almost 30% of cases, requiring the use of more sophisticated techniques. Computed tomography, magnetic resonance imaging and positron emission tomography are promising imaging modalities. Improved understanding of its pathophysiology and the development of relevant diagnostic strategies enables accelerated identification and treatment, and thus an improved prognosis.
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44

Brusch, John L. Infective Endocarditis: Management in the Era of Intravascular Devices. Taylor & Francis Group, 2007.

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45

Brusch, John L. Infective Endocarditis: Management in the Era of Intravascular Devices. Taylor & Francis Group, 2007.

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46

C, Shanson D., ed. Septicaemia and endocarditis: Clinical and microbiological aspects. Oxford: Oxford University Press, 1989.

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47

Infective Endocarditis: Management in the Era of Intravascular Devices (Infectious Disease and Therapy). Informa Healthcare, 2007.

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48

Federation, International Dental, ed. Guidelines for antibiotic prophylaxis of infective endocarditis for dental patients with cardiovascular disease. London: Fédération dentaire internationale, 1987.

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49

Grisoli, Dominique, and Didier Raoult. Prevention and treatment of endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0161.

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Initially always lethal, the prognosis of infective endocarditis (IE) has been revolutionized by antibacterial therapy and valve surgery. Nevertheless, it remains one of the deadliest infectious diseases, with ≥30% of patients dying within a year of diagnosis. Its incidence has also remained stable at 25–50 cases per million per year, and results predominantly from a combination of bacteraemia and a predisposing cardiac condition, including endocardial lesions and/or intracardiac foreign material. While antibiotic prophylaxis is recommended by various learned societies to cover healthcare procedures with the potential of causing bacteraemia in at-risk patients, there is no evidence to support this strategy. Even though the benefits are hypothetical, national guidelines should still be followed to avoid medico-legal issues. General preventive measures, such as education of clinicians and at-risk patients appear to be more crucial. Invasive procedures, especially intravenous catheterization, should be kept to the minimum possible. The severity of IE mandates a multidisciplinary and standardized approach to treatment, with involvement of dedicated surgeons within specialist centres. Standardized antibiotic protocols have produced dramatic reductions in hospital and 1-year mortality in reference centres. Most deaths now result from complications that constitute definite surgical indications, so optimization of surgical management and avoidance of delay will clearly improve prognosis. This disease has now entered an ‘early surgery’ era, with a more aggressive surgical approach showing promising results. Conditions such as septic shock, sudden death, and vancomycin-resistant staphylococcal endocarditis still constitute therapeutic and research challenges, and justify an important role for specialist centres.
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50

Török, M. Estée, Fiona J. Cooke, and Ed Moran. Cardiovascular infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199671328.003.0015.

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This chapter covers infective endocarditis characterized by infections of the endocardial surface of the heart, intravascular catheter-related infections, endovascular infections, myocarditis (which is an inflammatory disease of the myocardium), pericarditis (which is an inflammation of the pericardium), and mediastinitis (which is an infection involving the mediastinal structures).
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