Relevant bibliographies by topics / Infectious mononucleosis (IM)

Academic literature on the topic 'Infectious mononucleosis (IM)'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Infectious mononucleosis (IM)"

1

Skulnick, Martin, Donald E. Low, Andrew E. Simor, Mohan Patel, Pauline George, and Robert Chua. "Comparative Evaluation of Seven Commercial Tests for Detection of Heterophile Antibody in Infectious Mononucleosis." Canadian Journal of Infectious Diseases 3, no. 1 (1992): 23–26. http://dx.doi.org/10.1155/1992/510261.

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Detection of heterophile antibodies in infectious mononucleosis is the most rapid and cost-effective method for confirming the clinical diagnosis of the disease. This study compared seven commercial test kits (the Oxoid Infectious Mononucleosis Kit [Oxoid Ltd], Immunoscan Im-Latex [Baxter Travenol], Mono-Latex [Wampole Laboratories], Monospot and Im Screen Test [Ortho Diagnostics], Immunoscan Im-RBC Test [Baxter Travenol], and Infectious Mononucleosis Test [NCS Diagnostics]) to the Davidsohn differential test. All of the kits were shown to be acceptable for use, with specificities and sensitivities greater than 96.5% and 95.5%, respectively.
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2

Zaadstra, BM, AMJ Chorus, S. van Buuren, H. Kalsbeek, and JM van Noort. "Selective association of multiple sclerosis with infectious mononucleosis." Multiple Sclerosis Journal 14, no. 3 (April 2008): 307–13. http://dx.doi.org/10.1177/1352458507084265.

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Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population-based case-control study involving 2877 MS cases and 2673 controls in the Netherlands. We examined the frequency of different common infections and afflictions before the age of 25 and the age at which they occurred, using a self-administered questionnaire. The Odds ratios (ORs) for the occurrence of a variety of clinically manifest common childhood infections including rubella, measles, chicken pox and mumps before the age of 25 for MS cases versus controls ranged between 1.14 and 1.42, values similar to those for irrelevant probe variables used to reveal recall bias. In contrast, the OR for clinically manifest IM in MS cases versus controls, corrected for demographic variables, was 2.22 (95% confidence interval 1.73 — 2.86; P < 0.001). The average age of onset of IM in the population of MS cases (16.5 years) did not differ from controls (16.8 years). Our data confirm previous much smaller studies to show that the risk for MS is significantly enhanced by prior IM, and extend those previous data by showing that this association is far stronger than with other common childhood infections or afflictions. Multiple scelerosis 2008; 14: 307—313. http://msj.sagepub.com
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Odalovic, Bozidar, Milan Jovanovic, Radojica Stolic, Branislav Belic, Simon Nikolic, and Predrag Mandic. "Spontaneous splenic rupture in infectious mononucleosis." Srpski arhiv za celokupno lekarstvo 146, no. 5-6 (2018): 320–22. http://dx.doi.org/10.2298/sarh160629207o.

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Introduction. Spontaneous splenic rupture is a rare but potentially fatal complication of infectious mononucleosis (IM). It occurs in only 0.1?0.5% of cases of this disease. The aim of this paper was to present a case with spontaneous splenic rupture after IM. Case outline. A 22-year-old female patient was feeling better one month after she was treated for infectious mononucleosis, and started training volleyball. Two weeks after starting the training, she felt severe abdominal pain. The diagnosis of rupture was confirmed with computer tomography. Splenectomy was successfully performed. The postoperative course was uneventful and the patient recovered with no need for blood transfusion. Conclusion. Timely diagnosis and setting indications for surgical treatment are crucial in healing. Patients should wait to start with sport activities at least two months if the size of the spleen is within normal range.
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Odame, John, Joan Robinson, Nasser Khodai-Booran, Simon Yeung, Tony Mazzulli, Derek Stephens, and Upton D. Allen. "Correlates of Illness Severity in Infectious Mononucleosis." Canadian Journal of Infectious Diseases and Medical Microbiology 25, no. 5 (2014): 277–80. http://dx.doi.org/10.1155/2014/514164.

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INTRODUCTION: Understanding the spectrum and frequencies of Epstein-Barr virus (EBV) complications and markers of illness severity in immunocompetent patients with primary EBV infection will inform management of patients with EBV-related illnesses.OBJECTIVES:To determine the clinical and laboratory correlates of illness severity among infants, children and youth with infectious mononucleosis (IM).METHODS: Study subjects with confirmed IM were prospectively enrolled. Illness severity was assessed at baseline and at six weeks using a scoring tool. Peripheral blood viral loads served as a measure of viral burden.RESULTS: Among 32 children and young adults with IM, the median age was 16 years (range two to 24 years). The predominant clinical findings were lymphadenopathy (23 of 32 [72%]), pharyngitis (16 of 32 [50%]), fever (nine of 32 [28%]) and splenomegaly (six of 32 [19%]). With respect to symptoms or signs that persisted to at least six weeks after illness onset, the predominant complaint was lymphadenopathy in 35% of subjects available for reassessment. Deranged liver function tests were present at presentation in up to 44% of subjects. Patients with the highest viral loads at presentation had significantly higher illness severity scores associated with fatigue (P=0.02). Other than the scores associated with fatigue, viral load values were not significantly correlated with the illness severity scores at baseline and at six weeks.CONCLUSION: In IM, viral loads are not necessarily correlated with illness severity, with the exception of fatigue. EBV-related hepatitis is common in IM, confirming the status of this virus as a relatively common cause of transient hepatitis in children and youth. This entity is not necessarily a marker of disease severity.
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Apriasari, Maharani Laillyza. "Methisoprinol as an immunomodulator for treating infectious mononucleosis." Dental Journal (Majalah Kedokteran Gigi) 49, no. 1 (December 5, 2016): 1. http://dx.doi.org/10.20473/j.djmkg.v49.i1.p1-4.

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Background: Infectious mononucleosis (IM) is the self limiting disease that associated with primary Epstein Barr virus (EBV). It is a gamma herpes virus. EBV infection is follows saliva-transfer by kissing or sexual intercourse. The most clinical manifestation in IM consists mainly of the specific sign: pharyngitis, fever, and lymphadenopathy. The main therapy is supportive treatment. Actually the antiviral therapy is required for the host with high response immune. Purpose: The aimed of this study was to report the therapy of IM using methisoprinol. Case: The woman patient, 33 years old, came to hospital by suffering pharyngitis and swolen on left neck. It had been since 3 days ago. Case management: She had come to Puskesmas that were given amoxycillin capsul 500 mg three times a day for three days and paracetamol tablet 500mg three times a day for three days, but she was still ill. Then she came to RSGM Hasan Aman Banjarmasin. She was diagnosed as IM. The instruction were isolation and bed rest for a week. She had to eat sofly and drink water highly. The therapy were amoxycillin capsul 500 mg three times a day for seven days, methisoprinol caplet 500 mg three times a day for seven days, natrium dikofenak tablet 50 mg three times a day for seven days. She was asked to see the dentist next 7 days. In this case, she were not given acyclovir. Conclusion: IM is self limiting disease. IM is the disease with spesific clinical syndrome that associated with primary EBV infection. Depend on the base of clinical experiences, the supportive treatment is adviced for patient of IM. Methisoprinol has both immunomodulator and antiviral properties.
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6

Foss, HD, H. Herbst, M. Hummel, I. Araujo, U. Latza, C. Rancso, F. Dallenbach, and H. Stein. "Patterns of cytokine gene expression in infectious mononucleosis." Blood 83, no. 3 (February 1, 1994): 707–12. http://dx.doi.org/10.1182/blood.v83.3.707.707.

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Abstract Primary infection with Epstein-Barr virus (EBV) may arise as infectious mononucleosis (IM) in adolescents and young adults. Morphologically, IM- affected lymphoid tissue is characterized by expanded interfollicular areas with formation of atypical lymphoid blasts. It is assumed that morphology and clinical presentation of IM are related to characteristic patterns of cytokine production by EBV-infected and reactive cells. We studied IM tonsils of eight patients and six normal tonsils with a double in situ hybridization procedure using [35S]- labeled RNA probes specific for various cytokines and digoxigenin- labeled probes for the detection of the nuclear EBV encoded RNA transcripts, EBER 1 and 2. All of the IM cases displayed the same distinct cytokine gene expression pattern. When compared with interfollicular areas of normal tonsils, expression of lymphotoxin (LT), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 beta, but not IL-8 or IL-1 alpha was strongly enhanced in interfollicular areas in IM tonsils. LT was expressed predominantly by EBV-infected cells. TNF-alpha transcripts were also present in EBV- infected cells, although in smaller proportions. IL-6 specific signals were only found in few EBV-infected cells. IL-1 alpha-, IL-1 beta-, and IL-8-specific signals were not observed in EBV-infected cells, but were present at high signal intensity in many cells within and around foci of EBV-infected cells (IL-1 beta), next to areas of necrosis (IL-8, IL- 1 beta), or in epithelial cells (IL-1 alpha). These data suggest that EBV infection in form of IM results in induction of specific sets of cytokine genes in EBV-infected and in neighboring EBV-negative cells contributing to the characteristic morphology and cellular arrangement of the lesion as well as the clinical presentation.
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7

Foss, HD, H. Herbst, M. Hummel, I. Araujo, U. Latza, C. Rancso, F. Dallenbach, and H. Stein. "Patterns of cytokine gene expression in infectious mononucleosis." Blood 83, no. 3 (February 1, 1994): 707–12. http://dx.doi.org/10.1182/blood.v83.3.707.bloodjournal833707.

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Primary infection with Epstein-Barr virus (EBV) may arise as infectious mononucleosis (IM) in adolescents and young adults. Morphologically, IM- affected lymphoid tissue is characterized by expanded interfollicular areas with formation of atypical lymphoid blasts. It is assumed that morphology and clinical presentation of IM are related to characteristic patterns of cytokine production by EBV-infected and reactive cells. We studied IM tonsils of eight patients and six normal tonsils with a double in situ hybridization procedure using [35S]- labeled RNA probes specific for various cytokines and digoxigenin- labeled probes for the detection of the nuclear EBV encoded RNA transcripts, EBER 1 and 2. All of the IM cases displayed the same distinct cytokine gene expression pattern. When compared with interfollicular areas of normal tonsils, expression of lymphotoxin (LT), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 beta, but not IL-8 or IL-1 alpha was strongly enhanced in interfollicular areas in IM tonsils. LT was expressed predominantly by EBV-infected cells. TNF-alpha transcripts were also present in EBV- infected cells, although in smaller proportions. IL-6 specific signals were only found in few EBV-infected cells. IL-1 alpha-, IL-1 beta-, and IL-8-specific signals were not observed in EBV-infected cells, but were present at high signal intensity in many cells within and around foci of EBV-infected cells (IL-1 beta), next to areas of necrosis (IL-8, IL- 1 beta), or in epithelial cells (IL-1 alpha). These data suggest that EBV infection in form of IM results in induction of specific sets of cytokine genes in EBV-infected and in neighboring EBV-negative cells contributing to the characteristic morphology and cellular arrangement of the lesion as well as the clinical presentation.
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8

Hanna, Brendan C., Ronan McMullan, and Samuel J. Hall. "Corticosteroids and peritonsillar abscess formation in infectious mononucleosis." Journal of Laryngology & Otology 118, no. 6 (June 2004): 459–61. http://dx.doi.org/10.1258/002221504323219608.

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Peritonsillar abscess formation is an uncommon complication of infectious mononucleosis (IM). Early case reports implicated corticosteroids in the development of such abscesses, however, subsequent studies suggested that these drugs do not promote the formation of abscesses at several sites outside the central nervous system. It has recently been demonstrated that zwitterionic polysaccharides, in bacterial capsules, form complexes with CD4+ T lymphocytes leading to abscess formation. A patient is presented who developed peritonsillar abscess a few days after initiation of corticosteroid therapy for IM; the medical literature was reviewed in respect of this subject. It appears that the occurrence of these abscesses in IM is not strongly linked to corticosteroid treatment. The authors, therefore, recommend that steroids should not be withheld from patients with severe IM on the basis that they may precipitate the development of peritonsillar abscess.
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9

Stevenson, D. S., G. Webster, and I. A. Stewart. "Acute tonsillectomy in the management of infectious mononucleosis." Journal of Laryngology & Otology 106, no. 11 (November 1992): 989–91. http://dx.doi.org/10.1017/s0022215100121541.

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AbstractLife-threatening upper airway obstruction can be caused by tonsillopharyngitis secondary to infectious mononucleosis (IM). The administration of corticosteroids, emergency tracheostomy and acute tonsillectomy have been advocated as ways of managing this problem. In a series of 25 patients admitted over a five-year period with IM, 15 were judged to have symptoms severe enough to warrant the administration of corticosteroids. Six of these 15 patients had little improvement in their condition and thus underwent acute tonsillectomy. There were no significant complications of this surgery. A further three patients who received corticosteroids required tonsillectomy for recurrent tonsillitis later in the study period. By contrast, only one of the ten patients who did not receive corticosteroids subsequently required tonsillectomy. Acute tonsillectomy is of value in selected cases of IM tonsillopharyngitis. It may decrease the morbidity of recurrent tonsillitis after IM, in addition to averting the immediate risk of respiratory obstruction.
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10

Trisko, A. A., Marina G. Avdeeva, and N. V. Kolesnikova. "Clinical and immunological peculiarity of acute Epstein-Barr virus infection in adults." Epidemiology and Infectious Diseases 21, no. 3 (June 15, 2016): 130–35. http://dx.doi.org/10.17816/eid40908.

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The goal - improving the quality of the diagnosis of acute infectious mononucleosis (IM) in adults on the basis of a comparative study of cytokine status in MI, acute tonsillitis and acute viral hepatitis. Materials and methods. We observed three groups of patients hospitalized in «Specialized Clinical Hospital of Infectious Diseases of the Ministry of Health of the Krasnodar Territory» in 2012-2014: 29 patients with myocardial infarction (group 1), 25 - with acute tonsillitis (group 2), 19 - with acute viral hepatitis (group 3) and the control group. The groups were matched by sex, age and severity of the disease. In the acute phase of the disease the level of cytokines IL-1a, IL-1β, RaIL-1, IL-4, INF-y in serum was studied by ELISA. Results. At the height of the infectious mononucleosis increased content of IL-1a, IL-1β and INF-y was observed. In acute viral hepatitis significant increase in IL-1β, a less pronounced increase in INF-y, and no increase in IL-1a were registered. Acute tonsillitis is characterized by no increase in IL-1a and smaller increase in INF-y, compared to infectious mononucleosis. Significant difference between infectious mononucleosis and acute tonsillitis was a considerable rise of IL-1a and INF-y in first case. Acute viral hepatitis differs from infectious mononucleosis with pronounced increase in IL-1β. Conclusion. Determined significant intergroup cytokine status differences in patients with infectious mononucleosis, acute tonsillitis, and acute viral hepatitis may be helpful as additional diagnostic criteria for well examined infections in adults.
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Conference papers on the topic "Infectious mononucleosis (IM)"

1

Lesna, Alina. "PECULIARITIES OF CLINICAL-LABORATORY DIAGNOSTICS OF INFECTIOUS MONONUCLEOSIS IN CHILDREN." In DIE WICHTIGSTEN VEKTOREN FÜR DIE ENTWICKLUNG DER WISSENSCHAFT IM JAHR 2020, Chair Yana Kolesnik. European Scientific Platform, 2020. http://dx.doi.org/10.36074/24.01.2020.v1.35.

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Chandak, Twinkle R., PATRICK WONG, Erfan Hussain, and Angela KIM. "Fulminant Descending Mediastinitis, Bilateral Empyema And Respiratory Failure: A Rare Complication Of Infectious Mononucleosis (IM)." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5703.

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