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Relevant bibliographies by topics / Infections à Orthopoxvirus

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Journal articles

Academic literature on the topic 'Infections à Orthopoxvirus'

Author: Grafiati

Published: 23 September 2022

Last updated: 28 September 2022

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Journal articles on the topic "Infections à Orthopoxvirus"

1

Shchelkunov, S. N., and G. A. Shchelkunova. "We should be prepared to smallpox re-emergence." Problems of Virology, Russian journal 64, no. 5 (2019): 206–14. http://dx.doi.org/10.36233/0507-4088-2019-64-5-206-214.

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The review contains a brief analysis of the results of investigations conducted during 40 years after smallpox eradication and directed to study genomic organization and evolution of variola virus (VARV) and development of modern diagnostics, vaccines and chemotherapies of smallpox and other zoonotic orthopoxviral infections of humans. Taking into account that smallpox vaccination in several cases had adverse side effects, WHO recommended ceasing this vaccination after 1980 in all countries of the world. The result of this decision is that the mankind lost the collective immunity not only to s

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2

Douglas, Kirk Osmond, Claire Cayol, Kristian Michael Forbes, et al. "Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados." Pathogens 10, no. 6 (2021): 663. http://dx.doi.org/10.3390/pathogens10060663.

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Background: Rodents are reservoirs for several zoonotic pathogens that can cause human infectious diseases, including orthohantaviruses, mammarenaviruses and orthopoxviruses. Evidence exists for these viruses circulating among rodents and causing human infections in the Americas, but much less evidence exists for their presence in wild rodents in the Caribbean. Methods: Here, we conducted serological and molecular investigations of wild rodents in Barbados to determine the prevalence of orthohantavirus, mammarenavirus and orthopoxvirus infections, and the possible role of these rodent species

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3

Shchelkunova, G. A., and S. N. Shchelkunov. "40 Years without Smallpox." Acta Naturae 9, no. 4 (2017): 4–12. http://dx.doi.org/10.32607/20758251-2017-9-4-4-12.

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The last case of natural smallpox was recorded in October, 1977. It took humanity almost 20 years to achieve that feat after the World Health Organization had approved the global smallpox eradication program. Vaccination against smallpox was abolished, and, during the past 40 years, the human population has managed to lose immunity not only to smallpox, but to other zoonotic orthopoxvirus infections as well. As a result, multiple outbreaks of orthopoxvirus infections in humans in several continents have been reported over the past decades. The threat of smallpox reemergence as a result of evol

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4

Tregubchak, T. V., T. V. Bauer, R. A. Maksyutov, and E. V. Gavrilova. "Cases of Orthopoxviral Infections around the World over a Period of 2008–2018." Problems of Particularly Dangerous Infections, no. 3 (October 23, 2021): 33–39. http://dx.doi.org/10.21055/0370-1069-2021-3-33-39.

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The eradication of smallpox has become one of the greatest successes of modern health science. This great achievement was made possible thanks to the widespread vaccination of the population. The last case of human infection with smallpox virus occurred in 1977. In 1980, at the 33rd session of the World Health Assembly, routine vaccination against that infection was recommended to be discontinued due to severe post-vaccination complications. However, humanity remains vulnerable to other orthopoxvirus infections closely related to smallpox virus. Recently, the cases of human infection with orto

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5

Khlusevich, Ya A., A. L. Matveev, E. P. Goncharova, I. K. Baykov, and N. V. Tikunova. "Immunogenicity of recombinant fragment of orthopoxvirus p35 protein in mice." Vavilov Journal of Genetics and Breeding 23, no. 4 (2019): 398–404. http://dx.doi.org/10.18699/vj19.508.

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Despite the elimination of smallpox, orthopoxviruses continue to be a source of biological danger for humans, as cowpox and monkey pox viruses circulate in nature and the last virus can cause both sporadic cases of human diseases and outbreaks of smallpox-like infection. In addition, periodic vaccination is necessary for representatives of some professions (scientists studying pathogenic orthopoxviruses, medical personnel, etc.). Vaccination against smallpox virus with live vaccinia virus, which was widely used during the elimination of smallpox, induces the formation of long-term immunity in

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6

Scaramozzino, Natale, Audrey Ferrier-Rembert, Anne-laure Favier, et al. "Real-Time PCR to Identify Variola Virus or Other Human Pathogenic Orthopox Viruses." Clinical Chemistry 53, no. 4 (2007): 606–13. http://dx.doi.org/10.1373/clinchem.2006.068635.

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Abstract Background: Variola virus (family Poxviridae, genus Orthopoxvirus) and the closely related cowpox, vaccinia, and monkeypox viruses can infect humans. Efforts are mounting to replenish the smallpox vaccine stocks, optimize diagnostic methods for poxviruses, and develop new antivirals against smallpox, because it is feared that variola virus might be used as a weapon of bioterrorism. Methods: We developed an assay for the detection of variola virus DNA. The assay is based on TaqMan chemistry targeting the 14-kD protein gene. For the 1st stage of the assay we used genus consensus primers

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7

Smith, Scott K., Victoria A. Olson, Kevin L. Karem, Robert Jordan, Dennis E. Hruby, and Inger K. Damon. "In Vitro Efficacy of ST246 against Smallpox and Monkeypox." Antimicrobial Agents and Chemotherapy 53, no. 3 (2008): 1007–12. http://dx.doi.org/10.1128/aac.01044-08.

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ABSTRACT Since the eradication of smallpox and the cessation of routine childhood vaccination for smallpox, the proportion of the world's population susceptible to infection with orthopoxviruses, such as variola virus (the causative agent of smallpox) and monkeypox virus, has grown substantially. In the United States, the only vaccines for smallpox licensed by the Food and Drug Administration (FDA) have been live virus vaccines. Unfortunately, a substantial number of people cannot receive live virus vaccines due to contraindications. Furthermore, no antiviral drugs have been fully approved by

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8

Prichard, Mark N., Kathy A. Keith, Debra C. Quenelle, and Earl R. Kern. "Activity and Mechanism of Action of N-Methanocarbathymidine against Herpesvirus and Orthopoxvirus Infections." Antimicrobial Agents and Chemotherapy 50, no. 4 (2006): 1336–41. http://dx.doi.org/10.1128/aac.50.4.1336-1341.2006.

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ABSTRACT N-Methanocarbathymidine [(N)-MCT] is a conformationally locked nucleoside analog that is active against some herpesviruses and orthopoxviruses in vitro. The antiviral activity of this molecule is dependent on the type I thymidine kinase (TK) in herpes simplex virus and also appears to be dependent on the type II TK expressed by cowpox and vaccinia viruses, suggesting that it is a substrate for both of these divergent forms of the enzyme. The drug is also a good inhibitor of viral DNA synthesis in both viruses and is consistent with inhibition of the viral DNA polymerase once it is act

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9

Shchelkunov, S. N., T. V. Bauer, S. N. Yakubitskiy, A. A. Sergeev, A. S. Kabanov, and S. A. Pyankov. "Mutations in the A34R gene increase the immunogenicity of vaccinia virus." Vavilov Journal of Genetics and Breeding 25, no. 2 (2021): 139–46. http://dx.doi.org/10.18699/vj21.017.

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Vaccination is the most simple and reliable approach of protection to virus infections. The most effective agents are live vaccines, usually low-virulence organisms for humans and closely related to pathogenic viruses or attenuated as a result of mutations/deletions in the genome of pathogenic virus. Smallpox vaccination with live vaccinia virus (VACV) closely related to smallpox virus played a key role in the success of the global smallpox eradication program carried out under the World Health Organization auspices. As a result of the WHO decision as of 1980 to stop smallpox vaccination, huma

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10

Maksyutov, R. A., S. N. Yakubitskyi, I. V. Kolosova, and S. N. Shchelkunov. "Comparing New-Generation Candidate Vaccines against Human Orthopoxvirus Infections." Acta Naturae 9, no. 2 (2017): 88–93. http://dx.doi.org/10.32607/20758251-2017-9-2-88-93.

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The lack of immunity to the variola virus in the population, increasingly more frequent cases of human orthopoxvirus infection, and increased risk of the use of the variola virus (VARV) as a bioterrorism agent call for the development of modern, safe vaccines against orthopoxvirus infections. We previously developed a polyvalent DNA vaccine based on five VARV antigens and an attenuated variant of the vaccinia virus (VACV) with targeted deletion of six genes (VAC6). Independent experiments demonstrated that triple immunization with a DNA vaccine and double immunization with VAC6 provide protect

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