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1

Nagy, Andras, and Kursad Turksen, eds. Induced Pluripotent Stem (iPS) Cells. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2119-6.

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2

Turksen, Kursad, and Andras Nagy, eds. Induced Pluripotent Stem (iPS) Cells. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3055-5.

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3

Yildirim, Sibel. Induced Pluripotent Stem Cells. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-2206-8.

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4

Sullivan, Patrick J. Induced stem cells. Hauppauge, N.Y: Nova Science, 2011.

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5

Sullivan, Patrick J. Induced stem cells. Hauppauge, N.Y: Nova Science, 2011.

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6

Ding, Baojin, and Yu Tang, eds. Human Induced Pluripotent Stem Cells. New York, NY: Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3999-3.

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7

Turksen, Kursad, ed. Induced Pluripotent Stem Cells and Human Disease. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2585-9.

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8

Ye, Kaiming, and Sha Jin, eds. Human Embryonic and Induced Pluripotent Stem Cells. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-267-0.

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9

Heine, Vivi M., Stephanie Dooves, Dwayne Holmes, and Judith Wagner. Induced Pluripotent Stem Cells in Brain Diseases. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2816-5.

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10

Zhao, Xiaoyang. Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8819-9.

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11

Amit, M., and Joseph Itskovitz-Eldor. Atlas of human pluripotent stem cells: Derivation and culturing. New York: Humana Press, 2012.

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12

Sha, Jin, and SpringerLink (Online service), eds. Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols. Totowa, NJ: Springer Science+Business Media, LLC, 2012.

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13

Song, Loujin. Development of Novel Therapeutics for Timothy Syndrome Using Human Induced Pluripotent Stem Cells. [New York, N.Y.?]: [publisher not identified], 2017.

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14

iPS saibō no sangyōteki ōyō gijutsu: Industrial applied technology of induced pluripotent stem cells. Tōkyō-to Chiyoda-ku: Shī Emu Shī Shuppan, 2009.

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15

Nat, Roxana, and Andreas Eigentler. Cell Culture, iPS Cells and Neurodegenerative Diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0013.

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Somatic reprogramming technology, which enables the conversion of adult human non-neural cells into neurons, has progressed rapidly in recent years. The derivation of patient-specific induced pluripotent stem (iPS) cells has become routine. The inherent broad differentiation potential of iPS cells makes possible the generation of diverse types of human neurons. This constitutes a remarkable step in facilitating the development of more appropriate and comprehensive preclinical human disease models, as well as for high throughput drug screenings and cell therapy. This chapter reviews recent progress in the human iPS cell culture models related to common and rare NDDs, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, spinal muscular atrophy, and degenerative ataxias. It focuses on the pathophysiological features revealed in cell cultures, and the neuronal subtypes most affected in NDDs. The chapter discusses the validity, limitation, and improvements of this system in faithfully and reproducibly recapitulating disease pathology.
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16

Pletnikov, Mikhail V., Guo-Li Ming, and Christopher A. Ross. Animal and Cellular Models of Psychotic Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0015.

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Animal and cell models are experimental systems developed to study particular aspects of a disease, as no model can accurately reflect all features of the disease. In this critical review we mention some of the nongenetic models but focus on genetic mouse models, evaluate their advantages and limitations, and comment on potential new prospects for the field. The ability to reprogram somatic cells from patients and unaffected donors to induced pluripotent stem cells (iPSCs) has the potential to substantially enhance our knowledge of normal cellular development and disease pathogenesis. The use of cell and animal models will help elucidate basic cellular and molecular mechanisms of pathogenesis, which will enable the development of targeted therapeutic approaches.
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17

Yildirim, Sibel. Induced Pluripotent Stem Cells. Springer, 2012.

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18

Drapeau, Elodie, Hala Harony-Nicolas, and Jacqueline N. Crawley. Animal and Cellular Models of Pediatric Psychiatric Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0061.

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The study of childhood psychiatric disorders is especially challenging, not only because of the difficulties in obtaining relevant human samples but also because of ethical considerations regarding the ability of children to provide informed consent. Models that can be experimentally manipulated are therefore indispensable to study those disorders. Traditionally, biological psychiatry research has extensively employed animal models and characterizations of rodent behavior. More recently, induced pluripotent stem cells (iPSCs), and induced differentiation of iPSCs into different types of brain cells have offered new alternative strategies to elucidate mechanisms underlying cellular processes. Regardless of how they are created, optimal models should demonstrate face validity, construct validity, and predictive validity to be considered most relevant. This chapter highlights the major animal and cellular models currently used in the research of childhood-onset psychiatric disorders.
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19

Ding, Baojin. Human Induced Pluripotent Stem Cells. Springer, 2024.

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20

Induced Pluripotent Stem Cells Springerbriefs in Stem Cells. Springer, 2011.

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21

Turksen, Kursad, and Andras Nagy. Induced Pluripotent Stem Cells: Methods and Protocols. Springer, 2022.

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22

Turksen, Kursad, and Andras Nagy. Induced Pluripotent Stem Cells: Methods and Protocols. Springer New York, 2019.

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23

Induced Pluripotent Stem Cells: Methods and Protocols. Springer, 2023.

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24

Update on Induced Pluripotent Stem Cells [Working Title]. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.82950.

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25

Ahmed Al-Anazi, Khalid, ed. Update on Mesenchymal and Induced Pluripotent Stem Cells. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.77857.

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26

Update on Mesenchymal and Induced Pluripotent Stem Cells. IntechOpen, 2020.

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27

Zhao, Xiaoyang. Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells. Springer, 2016.

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28

Zhao, Xiaoyang. Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells. Springer, 2014.

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29

Zhao, Xiaoyang. Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells. Springer London, Limited, 2014.

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30

Turksen, Kursad, and Andras Nagy. Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization. Springer New York, 2016.

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31

Turksen, Kursad, and Andras Nagy. Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization. Springer New York, 2015.

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32

Itskovitz-Eldor, Joseph, and Michal Amit. Atlas of Human Pluripotent Stem Cells: Derivation and Culturing. Humana, 2016.

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33

Itskovitz-Eldor, Joseph, and Michal Amit. Atlas of Human Pluripotent Stem Cells: Derivation and Culturing. Springer, 2011.

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34

Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols. Springer, 2023.

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35

Turksen, Kursad. Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols. Springer, 2022.

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36

Induced Pluripotent Stem Cells in Brain Diseases Springerbriefs in Neuroscience. Springer, 2011.

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37

Ye, Kaiming, and Sha Jin. Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols. Humana Press, 2016.

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38

Allsopp, Tim, and G. Sitta Sittampalam. Induced Pluripotent Stem Cells for Disease Modelling, Drug Discovery and Toxicology Testing: Regenerative Pharmacology, Drug Discovery and Development. Royal Society of Chemistry, The, 2017.

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39

Dooves, Stephanie, Dwayne Holmes, Judith Wagner, and Vivi M. Heine. Induced Pluripotent Stem Cells in Brain Diseases: Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine. Springer London, Limited, 2012.

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40

Calcium Handling in HipscDerived Cardiomyocytes Springerbriefs in Stem Cells. Springer, 2012.

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41

Brennand, Kristen. Application of Stem Cells to Understanding Psychiatric Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0005.

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While much has been learned through clinical post-mortem and neuroimaging studies of patients and animal models of autism spectrum disorder (ASD), bipolar disorder (BD) and schizophrenia (SZ), these classical approaches have yet to fully elucidate the interaction of complex genetic risk factors on disease predisposition. The derivation of human induced pluripotent stem cells (hiPSCs) from patients with psychiatric disorders permits the study of the full complement of risk variants (known and unknown) that underlie disease predisposition, precisely in the cell types relevant to disease. The following chapter covers work to date regarding the advancements in the use of hiPSCs to model psychiatric disorders.
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