Dissertations / Theses on the topic 'Induced-pluripotent Stem Cell-derived Hepatocytes'
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Szkolnicka, Dagmara Maria. "MicroRNA regulation of drug metabolism in stem cell-derived hepatocytes." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23421.
Full textWills, Lauren Raquel. "Investigating Induced Pluripotent Stem Cells for Tissue Engineering and Hepatotoxicity Applications." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/101006.
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Chen, Xike. "Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage." Kyoto University, 2019. http://hdl.handle.net/2433/242390.
Full textFatica, Erica Marie. "Investigating Cardiac Metabolism in Barth Syndrome Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1556630870935279.
Full textNishimura, Koji. "Transplantation of murine induced pluripotent stem cell-derived neural progenitors into the cochlea." Kyoto University, 2012. http://hdl.handle.net/2433/157416.
Full textSachamitr, Supatra. "Exploiting the use of induced pluripotent stem cell derived immune cells for immunotherapy." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:89315b6b-a8cd-4a6f-8c43-3506d8dd1725.
Full textZhang, Jiao, and 张姣. "Regulation of cell proliferation and modulation of differentiation in human induced pluripotent stem cell-derived mesenchumal stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617503.
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Medicine
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Doctor of Philosophy
Jambi, Majed. "Differentiation of Human Atrial Myocytes from Endothelial Progenitor Cell-Derived Induced Pluripotent Stem Cells." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31158.
Full textRuiz-Torres, Sonya Jomara. "Modeling Fanconi Anemia in Squamous Epithelium using Human Induced Pluripotent Stem Cell-Derived Organoids." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573573103136768.
Full textCleary, Elaine Marie. "Effect of C9orf72 hexanucleotide repeat expansions on human induced pluripotent stem cell derived oligodendrocytes." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28816.
Full textSongstad, Allison Elaine. "Generating patient-specific induced pluripotent stem cell-derived choroirdal endothelium to study and treat macular degeneration." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2278.
Full textKamakura, Tsukasa. "Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture." Kyoto University, 2015. http://hdl.handle.net/2433/199202.
Full textKitahata, Shohei. "Critical Functionality Effects from Storage Temperature on Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Suspensions." Kyoto University, 2019. http://hdl.handle.net/2433/242417.
Full textKimura, Azuma. "Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells." Kyoto University, 2019. http://hdl.handle.net/2433/242422.
Full textNakane, Takeichiro. "Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue." Kyoto University, 2018. http://hdl.handle.net/2433/232090.
Full textShiba, Takeshi. "Functional evaluation of the pathological significance of MEFV variants using induced pluripotent stem cell-derived macrophages." Kyoto University, 2020. http://hdl.handle.net/2433/253163.
Full textJuthaporn, Assawachananont. "Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice." Kyoto University, 2015. http://hdl.handle.net/2433/199159.
Full textTangruksa, Benyapa. "Cardiac hypertrophy in human stem cells-derived cardiomyocytes : Biomarker identification and pathway analysis of endotheline-1 induced cardiac hypertrophy in human induced pluripotent stem cells-derived cardiomyocytes." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18902.
Full textRobertson, Abigail. "Targeting the Hippo signalling pathway to enhance the protective effect of iPS cell derived cardiomyocytes." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/targeting-the-hippo-signalling-pathway-to-enhance-the-protective-effect-of-ips-cell-derived-cardiomyocytes(f80b12c7-5289-46f9-8829-28224f0c6270).html.
Full textMaifoshie, Evie. "Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for studying the role of MAP4K4 kinase in cell death." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44977.
Full textLi, Xiang. "Mitochondrial transfer from induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial and smooth muscle cells attenuates oxidative stress-induced injury." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/58260.
Full textShoji, Emi. "Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells." Kyoto University, 2015. http://hdl.handle.net/2433/200495.
Full textKocharyan, Avetik. "Derivation and Characterization of Pax7 Positive Skeletal Muscle Precursor Cells from Control and HGPS-derived induced Pluripotent Stem Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37517.
Full textZhao, Chen. "Investigation of the cell- and non-cell autonomous impact of the C9orf72 mutation on human induced pluripotent stem cell-derived astrocytes." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25903.
Full textAchberger, Kevin [Verfasser]. "Human retinal organoids - Exploration of a human induced pluripotent stem cell-derived in vitro model / Kevin Achberger." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1231790687/34.
Full textYulius, Hermanto. "Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia." Kyoto University, 2019. http://hdl.handle.net/2433/242389.
Full textO'Brien, Susanne. "Induced human pluripotent stem cell-derived NK cells as an alternative source of lymphocytes for anti-cancer immunotherapy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041819/.
Full textMiyawaki, Yoshifumi. "Zonisamide promotes survival of human induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats." Kyoto University, 2020. http://hdl.handle.net/2433/259730.
Full textGarg, Pretty [Verfasser], Kurt [Gutachter] Gottmann, and Christine R. [Gutachter] Rose. "Differentiation and characterization of induced pluripotent stem cell derived astrocytes / Pretty Garg ; Gutachter: Kurt Gottmann, Christine R. Rose." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1131799488/34.
Full textBorooah, Shyamanga. "Developing a patient-derived induced pluripotent stem cell model to understand the clinical and pathological changes in macular degeneration." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25471.
Full textKorogi, Yohei. "In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids." Kyoto University, 2019. http://hdl.handle.net/2433/243303.
Full textHatani, Takeshi. "Nano-structural Analysis of Engrafted Human Induced Pluripotent Stem Cell-derived Cardiomyocytes in Mouse Hearts Using a Genetic-probe APEX2." Kyoto University, 2019. http://hdl.handle.net/2433/236616.
Full textGuessoum, Celina Isabelle [Verfasser]. "Analysis of catecholamine-induced beta-adrenergic signaling in TTS by patient-specific pluripotent stem cell-derived cardiomyocytes / Celina Isabelle Guessoum." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/121670368X/34.
Full textZhong, Rujia [Verfasser], and Martin [Akademischer Betreuer] Borggrefe. "Effects of Gastrointestinal Cancer Cell Secretion on Ion Channel Functions of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes / Rujia Zhong ; Betreuer: Martin Borggrefe." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1228539901/34.
Full textHayano, Mamoru. "The Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N- Related Cardiac Sodium Channelopathy." Kyoto University, 2018. http://hdl.handle.net/2433/230995.
Full textMoad, Mohammad. "Influence of cell type of origin to the differentiation potential of induced pluripotent stem cells derived from human urinary tract cells." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2803.
Full textKikuchi, Tetsuhiro. "Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease." Kyoto University, 2012. http://hdl.handle.net/2433/159389.
Full textRyosaka, Makoto. "Expansion of human iPSC-derived ureteric bud organoids with repeated branching potential." Kyoto University, 2021. http://hdl.handle.net/2433/261606.
Full textOkuyama, Hideaki. "Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea." Kyoto University, 2020. http://hdl.handle.net/2433/253142.
Full textKomatsu, Kenichi. "Overexpressed wild-type superoxide dismutase 1 exhibits amyotrophic lateral sclerosis-related misfolded conformation in induced pluripotent stem cell-derived spinal motor neurons." Kyoto University, 2018. http://hdl.handle.net/2433/232077.
Full textGoldszer, Isaac M. "Biochemical fractionation of induced pluripotent stem cell derived motor neurons from an ALS patient with the Glycine-298-Serine TDP-43 mutation." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12112.
Full textTransactive response DNA-binding protein (TDP-43), and fused in sarcoma/translocated in liposarcoma (FUS/TLS) form protein aggregates in amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD). The sequencing of the TDP-43 gene TARDBP in a large patient population has shown more than 40 missense mutations that are now known to cause disease. The effect of genetic mutation on protein aggregation, and the pathogenesis of ALS is the focus of this study. In order to determine the effect of the TARDBP Glycine-298- Serine (G298S) missense mutation on protein aggregation in disease, induced pluripotent stem cells (iPSCs) were reprogrammed from control and G298S mutant fibroblasts, and differentiated into motor neurons using defined factors, and fractio- nated to determine the soluble and insoluble TDP-43 burden. There was an increase in insoluble TDP-43 in the ALS-patient-derived motor neuron lysates over a normal control, but the significance could not be assessed because of the small sample size. A toxicity assay using fluorescence activated cell sorting showed an unexpected trend towards healthier control neurons. Future studies should include quantified immunohistochemical analysis of motor neurons and use novel pharmaceuticals to attempt to correct aberrant TDP-43-mediated RNA processing.
Lambertz, Pascal [Verfasser], and Dobromir [Akademischer Betreuer] Dobrev. "Target validation of adenylyl cyclase 5 and adenylyl cyclase 6 in human induced pluripotent stem cell-derived cardiomyocytes / Pascal Lambertz ; Betreuer: Dobromir Dobrev." Duisburg, 2021. http://d-nb.info/1241963231/34.
Full textHildebrandt, Susanne [Verfasser]. "Generation of induced Pluripotent Stem Cell derived Endothelial Cells from Fibrodysplasia Ossificans Progressiva patients - a disease model of ActivinA and BMP-induced ALK2 receptor activation / Susanne Hildebrandt." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1233286528/34.
Full textGomes, Sara Ferreira Martins [Verfasser], and Alexandra [Gutachter] Schubert-Unkmeir. "Induced Pluripotent Stem Cell-derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection / Sara Ferreira Martins Gomes ; Gutachter: Alexandra Schubert-Unkmeir." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1196972168/34.
Full textTakaki, Tadashi. "Optical recording of action potentials in human induced pluripotent stem cell-derived cardiac single cells and monolayers generated from long QT syndrome type 1 patients." Kyoto University, 2019. http://hdl.handle.net/2433/242346.
Full textTsurumi, Fumitoshi. "The intracellular Ca²⁺ concentration is elevated in cardiomyocytes differentiated from hiPSCs derived from a Duchenne muscular dystrophy patient." Kyoto University, 2020. http://hdl.handle.net/2433/253462.
Full textAhmad, Faizzan Syed. "A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:17972018-6750-4e5c-8cc9-42e9c381f531.
Full textForsgren, Elin. "Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS." Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138948.
Full textVarje år insjuknar omkring 5300 personer i världen i motorneuronsjukdomen Amyotrofisk lateralskleros (ALS). Sjukdomen kännetecknas av degeneration av motorneuron i hjärnan och ryggmärgen, de nervceller som styr kroppens muskler, vilket leder till musklerförtvining och gradvis förlamning. ALS-patienter avlider oftast till följd av andningssvikt när sjukdomen når andningsmuskulaturen. I de allra flesta fall uppkommer ALS sporadiskt (SALS), det vill säga utan känd genetisk orsak, medan ärftliga fall (FALS) drabbar omkring 10 % och beror på mutationer i ett antal kända gener. Upp till 6 % av alla ALS fall kan härledas till mutationer i genen superoxid dismutas 1 (SOD1). SOD1 är ett enzym som ansvarar för att omvandla och oskadliggöra fria syreradikaler som bildas vid normal ämnesomsättning. 206 olika SOD1 mutationer har identifierats, alla orsakar inte ALS men många leder till att den tredimensionella proteinstrukturen förändras, vilket ökar proteinets benägenhet att felveckas. Initialt trodde man att SOD1 mutationer förhindrade proteinets normalfunktion och följaktligen orsakade ALS. Studier har emellertid visat att den enzymatiska funktionen ofta bevaras, även hos muterade proteiner. Däremot kan små mängder felveckat SOD1 störa andra viktiga cellulära funktioner. Felveckat SOD1 har en benägenhet att klumpa ihop sig och bilda aggregat i det centrala nervsystemet (CNS). Dessa aggregat återfinns hos patienter med såväl FALS som SALS vilket tyder på att även vildtyps-SOD1 kan felveckas och vara involverat i sjukdomsutvecklingen. De flesta studier är baserade på transgena musmodeller som uttrycker extremt stora mängder av muterat humant SOD1. Det är dock oklart hur väl studier i möss överensstämmer med sjukdomsutvecklingen hos ALS-patienter, där mängden SOD1 är betydligt lägre. En central fråga som fortfarande står obesvarad är varför just motorneuron degenererar i ALS, trots att SOD1 uttrycks i alla kroppens celler. Det övergripande syftet med den här avhandlingen har varit att karakterisera felveckat SOD1 i patientceller för att studera dess roll i ALSrelaterade sjukdomsmekanismer med fysiologiskt relevanta nivåer av SOD1. Samtliga studier är gjorda in vitro med celler från friska donatorer med vildtyps-SOD1, celler från patienter med SOD1-FALS, FALS som bär andra ALS-associerade gener, samt SALS. I de allra flesta fallen har vi analyserat både lösligt felveckat SOD1 samt aggregerade former av SOD1 proteinet.
Lepperhof, Vera [Verfasser], Jürgen [Akademischer Betreuer] Hescheler, and Stephan [Akademischer Betreuer] Rosenkranz. "Retention and therapeutic effect of co-injected murine mesenchymal stem cells and induced pluripotent stem cell derived cardiomyocytes in cryoinjured hearts of syngeneic mice / Vera Lepperhof ; Akademische Betreuer: Jürgen Hescheler, Stephan Rosenkranz." Köln : Deutsche Zentralbibliothek für Medizin, 2019. http://d-nb.info/1196549877/34.
Full textLi, Wener [Verfasser], Kaomei [Akademischer Betreuer] Guan-Schmidt, Swen [Gutachter] Hülsmann, and Viacheslav [Gutachter] Nikolaev. "Functional analysis of ryanodine receptor 2 mutations in induced pluripotent stem cell-derived cardiomyocytes from CPVT patients / Wener Li ; Gutachter: Swen Hülsmann, Viacheslav Nikolaev ; Betreuer: Kaomei Guan-Schmidt." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/1128902737/34.
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