Dissertations / Theses on the topic 'Incretin hormones'
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Baggio, Laurie L. "The role of incretin hormones in glucose homeostasis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ59004.pdf.
Full textEdholm, Therese. "The role of incretin peptides and ghrelin in upper gut motility and metabolic control /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-937-8/.
Full textMoss, Catherine Elizabeth. "G-protein coupled receptors modulating incretin hormone secretion." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648611.
Full textMcCool, Katherine E. "The effect of diet and adiposity on the secretion of incretin hormones in cats." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471605344.
Full textJoo, Erina. "The effects of nutrition intake on intestinal mucosal repair and metabolic regulation through gut hormones." Kyoto University, 2014. http://hdl.handle.net/2433/188804.
Full text0048
新制・課程博士
博士(人間・環境学)
甲第18366号
人博第679号
新制||人||163(附属図書館)
25||人博||679(吉田南総合図書館)
31224
京都大学大学院人間・環境学研究科共生人間学専攻
(主査)教授 林 達也, 教授 森谷 敏夫, 教授 石原 昭彦, 教授 津田 謹輔
学位規則第4条第1項該当
Parker, Helen Elizabeth. "Mechanisms underlying nutrient stimulated incretin hormone secretion." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608858.
Full textHabib, A. M. "Properties of incretin hormone secreting cells : a primary cells study." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599820.
Full textFernandes, Gustavo. "Avaliação do metabolismo glicêmico e perfil entero-hormonal no pós-operatório precose em pacientes abesos graves diabéticos submetidos à gastroplastia em Y de Roux.Comparação da oferta alimentar por via oral e por gastrostomia." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-29112017-091214/.
Full textINTRODUCTION: Type 2 diabetes mellitus (DM2) is a disease correlated with morbidly obesity. The obese patient has a suppressed incretin effect and consequent inbalance of glycemic homeostasis. Several studies have shown an improvement in DM2 after Gastroplasty with Roux-en-Y gastric bypass (RYGB). The mechanisms of glycemic control may be long-term and shortterm. The mechanisms of early action are linked to caloric restriction, improvement of insulin resistance, pancreatic beta cell function and return of the incretin effect through the increase of GLP1 and GIP, but the data are conflicting. METHODS: Eleven diabetic obese patients underwent RYGB with gastrostomy in gastric remnant after initial 10% weight loss. Patients were submitted to assessment of enterohormones, glycemic profile and Oral Glucose Tolerance Test (OGTT) in the preoperative period in a time curve that was compared to the postoperative period by Oral Via and Gastrostomy Via up to 7 days after the procedure .RESULTS: The mean age of the group was 46.09 ± 7.08 years. In the preoperative the mean weight was 120.97 ± 17.02 kilograms, height of 1.67 ± 0.11 meters, mean BMI of 44.06 ± 6, 59 kg/m2, mean fasting blood glucose of 194.55 ± 62.45 mg/dl and glycated hemoglobin 8.74 ± 1.64%. In 77.7% of the patients there was remission of DM2 in postoperative evaluated by the OGTT. Significant decrease in glycemia, insulinemia and HOMA-IR was also observed, regardless of the route of administration. There was a significant increase in GLP1 and reduction of GIP by the postoperative oral route. Ghrelin did not change. CONCLUSION: A reduction in glycemia and peripheral insulinal resistance was observed in early postoperative days of RYGB, independent of the food route. The change in incretin effect (increase of GLP1 and reduction of GIP) was only observed in the postoperative oral route
Abdullahi, Mohamed Mohamed. "GLP-1 REGULATES PROLIFERATION OF GLP-1 SECRETING CELLS THROUGH A FEEDBACK MECHANISM." Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-9756.
Full textAbstract Background and aim: Material and methods: Results/conclusions: These results suggest that GLP-1 regulates proliferation of the GLP-1-secreting cell through a feedback mechanism via its receptor. Since serum GLP-1 levels are decreased in type 2 diabetic patients, the effect of GLP-1 on the GLP-1-secreting cell proliferation suggested here provides a novel beneficial long-term effect of the incretin-based drugs in clinical practice i.e. through increase of the GLP-1-secreting cell mass, augmenting the incretin effect. In addition, the feedback mechanism action of GLP-1 reveals a new insight in regulation manner of the L-cell proliferation. Keywords:
Lu, Wendell J. "Role of Macronutrients in the Regulation and Secretory Mechanisms of Gastrointestinal Hormones, Glucagon-like Peptide-1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP), in Lymph." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204084153.
Full textWeitten, Mathieu. "Adaptations métaboliques et influence du régime alimentaire chez un hibernant food-storing." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ080/document.
Full textThis thesis presents the specific adaptations of food-storing hibernators that feed during hibernation, and the impact of diet quality on their annual cycle. In contrast to the fat-Storing species which fast during hibernation, the food-storing presents metabolic responses to an alternation of short fasting phases and hyperphagia. These responses involve one hand use of fat reserves during hibernation contributing to ketogenesis, which would be induced by adiponectin. On the other hand, maintaining a functional digestive system leading to the secretion of incretins, permits optimal nutrient absorption in the short inter-torpor euthermia. Increased glucose uptake in particular would restore body reserves to spare. Moreover, a lean protein diet enriched in fat and induces increased in body mass in pre-hibernation period causing reduced use of torpor thus an increased loss of mass during hibernation, and decreased reproductive success
Liu, Hui-Kang. "Modification of the function of insulin-secreting cells by beta-cell toxins, differentiation drugs, insulin mimetics, steroids, and incretic hormones and their stable analogues." Thesis, University of Ulster, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399055.
Full textHansotia, Tanya. "Elucidating novel biological actions of the incretin hormones GLP-1 and GIP /." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=442461&T=F.
Full textMarathe, Chinmay. "Relationships of gastric emptying with glycaemia, insulin secretion and the incretin effect in health and type 2 diabetes." Thesis, 2016. http://hdl.handle.net/2440/100746.
Full textThesis (Ph.D.) (Research by Publication) -- University of Adelaide, School of Medicine, 2016.
Maida, Adriano. "Effects of Enteroendocrine Hormones on Beta-cell Function and Glucose Homeostasis." Thesis, 2011. http://hdl.handle.net/1807/29800.
Full textSassoon, Daniel Jay. "Obesity alters global response to ischemia and GLP-1 agonism." Diss., 2016. http://hdl.handle.net/1805/10980.
Full textGlucagon-like peptide 1 (GLP-1) receptor agonists are a class of incretin based therapeutics which aid in blood glucose management in Type II diabetes mellitus (T2DM). Recent studies have demonstrated direct cardiovascular benefits conferred by these agents including protection in ischemia and heart failure. Despite these observations, human clinical trials fail to support improvements in cardiovascular outcomes independent of glucose lowering effects in the T2DM populations. Prior data from our lab demonstrate that obesity impairs GLP-1 associated increases in myocardial glucose uptake. However, the reasons for this impairment/resistance to cardiac effects of GLP-1 in the setting of obesity remain ill defined. This investigation tested the hypothesis that underlying differences in the cardiac proteome and microRNA (miR) transcriptome could contribute to distinct cardiac responses to ischemia and activation of GLP-1 signaling in the setting of obesity. To identify whether obesity modulated cardiac functional responses to GLP 1 related drugs, we first examined the effects of obesity on cardiac function, miR transcriptome, and proteome in response to short duration ischemia-reperfusion (I/R). We observed divergent physiologic responses (e.g. increased diastolic volume and systolic pressure in lean, decreased diastolic volumes in obese) to regional I/R in obese vs lean hearts that were associated with significant molecular changes as detected by protein mass spectrometry and miR microarray. Molecular changes were related to myocardial calcium handling (SERCA2a, histidine-rich Ca2+ binding protein), myocardial structure and function (titin), and miRs relating to cardiac metabolism, hypertrophy, and cell death, including miR-15, miR-30, miR-199a, miR-214. Importantly, these effects were modified differently by GLP-1 agonism in lean vs obese swine. Additional studies investigated the functional effects of 30 days of treatment with the GLP-1 analogue liraglutide on a model of slowly-developing, unrelieved coronary ischemia. Liraglutide failed to reduce infarct size or collagen deposition. However, analysis of left ventricular pressure-volume relationships support that liraglutide improved diastolic relaxation/filling, load-dependent indices of cardiac function, and cardiac efficiency in response to sympathetic stimulation in obese swine. Taken together, these findings support that miR and proteomic differences underlie distinct changes in functional cardiac responses to I/R and pharmacologic activation of GLP-1 signaling in the setting of obesity.
Pham, Hung. "Natural history of meal-induced changes in blood pressure, gastric emptying and incretin hormone secretion and approaches to the management of postprandial hypotension." Thesis, 2019. http://hdl.handle.net/2440/124702.
Full textThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2019
Chang, Jessica Lee Sing. "Gastric motor function in health and diabetes: implications for incretin hormone release and postprandial blood glucose regulation." Thesis, 2012. http://hdl.handle.net/2440/76101.
Full textThesis (M.Phil.) -- University of Adelaide, School of Medicine, 2012
Renner, Simone [Verfasser]. "Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor : a novel animal model for studying the consequences of impaired incretin hormone function / by Simone Renner." 2008. http://d-nb.info/1000269078/34.
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