To see the other types of publications on this topic, follow the link: Inclusion vitreuse.
Journal articles on the topic 'Inclusion vitreuse'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Inclusion vitreuse.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Guilhaumou, N., P. Dumas, G. L. Carr, and G. P. Williams. "Synchrotron Infrared Microspectrometry Applied to Petrography in Micrometer-Scale Range: Fluid Chemical Analysis and Mapping." Applied Spectroscopy 52, no. 8 (August 1998): 1029–34. http://dx.doi.org/10.1366/0003702981944797.
Full textAbstract:
The potentiality of synchrotron infrared microspectrometry was investigated for in situ analysis of fluid inclusions and volatiles of particular geological interest. Thanks to the intrinsic high brightness of the synchrotron infrared source, areas as small as a few μm2 can be probed, providing a high-contrast analysis of small inclusions in geological materials. We have identified organic components in such small volumes in their liquid and gaseous phase, thus allowing a deeper analysis of oil-water inclusions entrapped in diagenetic cements. Such detailed analysis opens up new perspectives in petroleum reservoir evolution studies. The high signal-to-noise ratio of spectra obtained in small volume allows a fast and accurate chemical mapping of the inclusion components. Drastic refraction effects preclude, at the present state, a quantitative analysis of either the volume or the thickness of the individual inclusions. Traces of volatiles such as CO2 and H2O are easily detected in the vitreous and gaseous part of the glass melt fluid inclusions. We have also profiled the hydroxyl concentration near a wall, and calculated the hydrogen diffusion coefficient in anhydrous minerals such as diopside.
2
Connors, Daniel, Gaurav Shah, Kevin Blinder, and Sabin Dang. "Early Versus Delayed Vitrectomy for Nondiabetic Vitreous Hemorrhage." Journal of VitreoRetinal Diseases 2, no. 2 (March 2018): 87–90. http://dx.doi.org/10.1177/2474126418758771.
Full textAbstract:
Purpose: To analyze the surgical and visual outcomes in patients who underwent early versus delayed vitrectomy for dense nondiabetic, nonvascular vitreous hemorrhage from undetermined cause. Methods: A retrospective, consecutive series evaluating all patients with a preoperative diagnosis of nondiabetic vitreous hemorrhage treated surgically at The Retina Institute over the past 5 years. Vitreous hemorrhage had to be described as dense, with first-order vessels not visualized on funduscopic examination. Exclusion criteria included a diagnosis of diabetes mellitus, retinal vascular disease, any prior intraocular surgery other than cataract extraction, or any previously diagnosed ocular conditions. A total of 275 patients and 286 eyes were evaluated, with 52 patients and 52 eyes meeting inclusion criteria. Surgical treatment was with standard pars plana vitrectomy. Results: Of the 52 eyes that met inclusion criteria, 32 (61.5%) were found to have at least 1 retinal break. Sixteen eyes (30.1%) had a rhegmatogenous retinal detachment. Mean time from diagnosis of the vitreous hemorrhage to surgical intervention was 15 days (range, 0-78 days). Early vitrectomy was defined as surgical intervention within 10 days of diagnosis, while late vitrectomy was defined as surgical intervention following 10 days. Of eyes that were found to have a retinal detachment, 75% were phakic and 25% were pseudophakic. Final postoperative visual acuity in the early surgery cohort was 20/66, while in the late surgery cohort was 20/89, which did not achieve statistical significance ( P = .67). Conclusion: A significant percentage of patients with retinal detachment were phakic at the time of vitreous hemorrhage (75%) as compared to pseudophakic. Data from the largest series to date indicate that in phakic patients with dense hemorrhage, the risk of retinal detachment is high and should prompt consideration for more urgent surgical intervention.
3
Talmon, Yeshayahu, Marc Adrian, and Jacques Dubochet. "Electron beam radiation damage to organic inclusions in vitreous, cubic, and hexagonal ice." Journal of Microscopy 141, no. 3 (March 1986): 375–84. http://dx.doi.org/10.1111/j.1365-2818.1986.tb02730.x.
Full text
4
Karwowski, Łukasz, Joachim Kusz, Andrzej Muszyński, Ryszard Kryza, Maciej Sitarz, and Evgeny V. Galuskin. "Moraskoite, Na2Mg(PO4)F, a new mineral from the Morasko IAB-MG iron meteorite (Poland)." Mineralogical Magazine 79, no. 2 (April 2015): 387–98. http://dx.doi.org/10.1180/minmag.2015.079.2.16.
Full textAbstract:
AbstractMoraskoite, a new natural phosphate of composition Na2Mg(PO4)F, has been found in the Morasko IAB-MG iron meteorite. The new phosphate occurs in a graphite-troilite inclusion enclosed in a kamacite-taenite matrix. Associated minerals in the inclusions are chlorapatite, buchwaldite, brianite, merrillite, a new phosphate phase of composition Na4MgCa3(PO4)4, chromite, enstatite (bronzite), kosmochlor, kosmochlor–augite, olivine, albite, orthoclase, quartz, cohenite, schreibersite, nickelphosphide, altaite, pyrrhotite, sphalerite, daubreelite, djerfischerite, whitlockite and native Cu. The inclusions are rimmed by a schreibersite-cohenite halo. Moraskoite forms aggregates up to 1.5 mm in size, with individual grains 20–300 μm across. It is colourless and transparent, with a white streak and vitreous lustre; fluorescence is weak blue in ultraviolet radiation (254 and 360 nm); hardness is 4–5; it has irregular, conchoidal fracture and cleavage is rarely observed. Calculated density (using the empirical formula) is 2.925 g cm–3. The moraskoite structure (Pbcn, a = 5.2117(10), b = 13.711(3), c = 11.665(2) Å, V = 833.6(3) Å3 and Z = 8) is similar to that of its synthetic analogue. The strongest diffraction lines of the moraskoite powder diffraction pattern are as follows (dhkl, I): 3.909(75), 3.382(52), 2.955(90), 2.606(100), 2.571(96), 2.545(68), 1.691 (67). In the Raman spectrum, the following characteristic bands are distinguished (cm–1, strong bands bold): 1114, 1027, 962, 589, 438, 336, 308, 279, 262, 244, 193, 184, 147 and 131. The Raman data prove the absence of H2O and CO2. Moraskoite is interpreted as being a primary phosphate, which crystallized together with graphite, troilite and other accessories inside the nodule.
5
Luais, Béatrice. "Immiscibilité entre liquides silicatés dans les mésostases et les inclusions vitreuses des andésites basiques de Santorin (Arc Egéen)." Bulletin de Minéralogie 110, no. 1 (1987): 93–109. http://dx.doi.org/10.3406/bulmi.1987.8028.
Full text
6
Arslanov, G. M., B. M. Aznabaev, T. R. Mukhamadeev, Z. R. Yanbukhtina, T. I. Dibaev, and G. R. Shakirova. "Electron Microscopic Retina Changes in Rabbit Eyes with Perfluorocarbon Liquids Intravitreal Tamponade." Ophthalmology in Russia 16, no. 1 (March 30, 2019): 81–87. http://dx.doi.org/10.18008/1816-5095-2019-1-81-87.
Full textAbstract:
Purpose. Analysis of electron microscopic changes in rabbit eyes with intravitreal tamponade of perfluorocarbon liquids (PFCL) (perfluoro-1,3-dimethylcyclohexane and perfluorodecalin).Material and Methods. The study was performed on Chinchilla breed rabbits. 25G vitrectomy with PFCL intravitreal tamponade was performed on 12 eyes of 6 rabbits (perfluorodecalin (Bausch+Lomb «Dk-line», USA) and perfluoro-1,3-dimethylcyclohexane (ZAO “Optimedservis”, Russia). Standard three-port vitrectomy technique was used. After removal of the vitreous body 2.5 ml of PFCL were injected in vitreous cavity. Research studies were performed in 5, 14 and 30 days after surgery by electron microscopy. Eyes were enucleated in 20 minutes after animal was killed by air embolization. Intact eyes were used as a control. All samples were prepared in same conditions. The damage of the retina architectonics and the presence of intracellular inclusions were evaluated.Results. Tamponade of the vitreous cavity by both types of PFCL in 5, 14 and 30 day caused following similar electron microscopic changes at date: swelling ganglion layer and dystrophy of inner and outer nuclear layer. Electron microscopic changes in outer nuclear layer appeared at 30 days. The photoreceptor neurons were characterized by single ultrastructural changes. Retina pigment epithelium cells had a typical ultrastructure.Conclusion. Intravitreal perfluoro-1,3-dimethylcyclohexane tamponade caused similar electron microscopic changes as well as perfluorodecalin in the experiment and it was relatively harmless to rabbit retina for up to 14 days. Irreversible changes in the retinal ultrastructure were not observed.
7
Simanjuntak, Gilbert W. S. "Reimplantasi Lensa Setelah Komplikasi Operasi Katarak." Kesmas: National Public Health Journal 6, no. 4 (February 1, 2012): 168. http://dx.doi.org/10.21109/kesmas.v6i4.95.
Full textAbstract:
Ada keterbatasan laporan implementasi lensa intraokuler sekunder di Indonesia. Penelitian ini bertujuan untuk melaporkan hasil implementasi lensa intraokuler sekunder di Rumah Sakit Communion of Churches in Indonesia (CCI) Cikini, Fakultas Kedokteran Universitas Kristen IndonesiaJakarta. Penelitian dengan sumber data sekunder rekam medis pasien dengan bedah inclusi eventful dengan atau tanpa implementasi lensa dan setiap komplikasi post operasi, termasuk penurunan penglihatan dan inflamasi katarak. Segmen anterior dan posterior diperiksa secara menyeluruh dan dicatat. Sinechiolisis dilakukan 360o dan viskoelastik disuntikkan untuk membuka ruangan antara iris dan kapsul rensi remain. Remain vitreous di depan chamber dipotong dan diangkat. Intraocular lens (IOL) ditanam di sulkus. Hasilnya yaitu ada 8 pasien yang memenuhi kriteria inklusi yang kemudian dievaluasi (50% adalah pria), 6 pasien underwent extracapsular catarac extraction (ECCE), dan 2 pasien underwent phacoemulsification before. Semua pasien mempunyai kornea sentral yang jernih. Ada 5 pasien denganuveitis dan opasitas vitreous. Ada 1 pasien dengan (AC IOL), 2 pasien dengan (PCIOL) terdislokasi sebagian pada rongga vitreous dan sisanya aphakic. Semua prosedur bedah dikerjakan dengan anastesi lokal retrobulbar dan diimplementasi IOL pada sulkus tanpa fiksasi. Rata-rata umuradalah 56,3 + 18,5 tahun. Rata-rata best corrected visual acuity (BCVA) sebelum operasi 0,33 + 0,26 dan setelah operasi 0,89 + 0,16 (p = 0,000). Rata-rata intraocular pressure (IOP) adalah 20,25 + 8,2 dan 15,25 + 3,5 mmHg sebelum dan sesudah operasi secara berurutan (p = 0,140). Pemantauan dilakukan 1 - 60 bulan. Implementasi IOL sekunder dapatmemperbaiki penglihatan dan mengurangi subjektif dan temuan klinik setelah operasi katarak sebelumnya.Kata kunci: Intraokuler, implementasi, katarakAbstractThere are limited reports of secondary intraocular lens implantation in Indonesia. The purpose of study is to report the result of secondary intraocular lens implantation in Cikini Communion of Churches in Indonesia (CCI) Hospital/Faculty of Medicine University Universitas Kristen Indonesia Jakarta. Retrospective study of medical records of patients with inclusioneventful cataract surgery with or without lens implantation with any complications postoperatively, including reduced vision and inflammation. Anterior and posterior segment findings were examine thoroughly and recorded. Synechiolysis done 360 degree and viscoelastic injected to open space between iris and remain lens capsule. Remain vitreous in anterior chambercut and removed. Intraocular lens (IOL) implanted in the sulcus. There are 8 patients that fulfills inclusion criteria which then evaluated (50% are men), 6 patients underwent extracapsular catarac extraction (ECCE), and 2 patientsunderwent phacoemulsification before. All patient have clear central cornea. There are 5 patients with uveitis and vitreous opacity. There are 1 patients with (AC IOL), 2 patients with (PC IOL) dislocated some part to vitreous cavity and the rest aphakic. All surgical procedures were done under local retrobulbar anesthesia and IOL implanted in the sulcus withoutfixation. Mean age were 56,3 + 18,5 years. Mean best corrected visual acuity (BCVA) preoperatively 0,33 + 0,26 and postoperatively 0,89 + 0,16 (p = 0,000). Mean intraocular pressure (IOP) were 20,25 + 8,2 and 15,25 + 3,5 mmHg pre and post operative respectively (p = 0,140). Follow up was 1 - 60 months. Secondary IOL implantation can improve vision and reduce subjective and clinical findings after remarkable cataract surgery.Key words: Intraocular, implementation, cataract
8
Fabro, Filippo, and Carl Herbort. "Need for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis." Klinische Monatsblätter für Augenheilkunde 235, no. 04 (April 2018): 424–35. http://dx.doi.org/10.1055/s-0043-124966.
Full textAbstract:
Abstract Background/Purpose Quantitative methods for posterior uveitis are necessary for precise appraisal and follow-up of inflammation in practice and in clinical trials. The aim of this study was to assess fluorescein angiography (FA), indocanine green angiography (ICGA), and enhanced depth imaging optical coherence tomography choroidal thickness (EDI-OCT CT) in two stromal choroiditis entities, birdshot retinochoroiditis (BRC), and Vogt-Koyanagi-Harada disease (VKH), as well as to determine (1) disease patterns, (2) respective response to therapy, and (3) their potential utility in clinical trials in comparison to vitreous haze, the present standard outcome used in clinical trials. Methods This retrospective study included newly diagnosed patients with BRC and VKH, seen at the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Angiographic signs were quantified using an established dual FA/ICGA scoring system for uveitis at presentation and on follow-up. FA/ICGA score ratios were compared between diseases to determine disease patterns. EDI-OCT CT was determined using a spectral domain instrument. Vitreous haze was determined using the SUN (Standardization of Uveitis Nomenclature) method. Results Among 1872 uveitis patients seen from 1995 to 2016, 8 newly diagnosed BRC patients (16 eyes) and 6 newly diagnosed VKH patients (12 eyes) had sufficient data for study inclusion. Patients with BRC and VKH at initial onset had mean FA scores of 16.1 ± 7.0 vs. 4.6 ± 2.1 (p < 0.0001), respectively, while mean ICGA scores were similarly high in the two diseases, 18.9 ± 3.6 (BRC) vs. 20.8 ± 7.5 (VKH). After therapy, FA and ICGA scores decreased significantly for both entities (− 60% of FA score and 55% of ICGA score in BRC vs. − 72% of FA score and − 87% for ICGA score in VKH). EDI-OCT CT decreased significantly in the two entities. Vitreous haze was almost absent in VKH and low in BRC. Conclusion Dual FA/ICGA scoring showed the diverse disease patterns of BRC and VKH; both the retina and choroid were involved at onset in BRC, whereas VKH was a pure choroidal disease with later spillover into the retina. Dual FA/ICGA allowed for the precise measurement of inflammation at onset and upon follow-up. EDI-OCT CT responded to therapy in both diseases but was found to be of limited use in this early/subacute disease phase because it lacked sensitivity to detect subclinical recurrences and was therefore only useful for long-term follow-up. Vitreous haze was low in both entities and thus useless as an inflammatory parameter.
9
Iaseniuc, O., M. Iovu, S. Rosoiu, M. Bardeanu, L. B. Enache, G. Mihai, O. Bordianu, et al. "Structural analysis of As-S-Sb-Te polycrystalline nanostructured semiconductors." Chalcogenide Letters 19, no. 11 (November 30, 2022): 841–46. http://dx.doi.org/10.15251/cl.2022.1911.841.
Full textAbstract:
The aim of this paper is to characterize the polycrystalline and vitreous phases in the As2S3-Sb2S3-Sb2Te3 systems using several techniques such as XRD, SEM, EDS, and micro-Raman spectroscopy. The As1.17S2.7Sb0.83Te0.40, As1.04S2.4Sb0.96Te0.60, As0.63S2.7Sb1.37Te0.30, and As0.56S2.4Sb1.44Te0.60 semiconductor chalcogenide bulk glasses were examined using Scanning Electron microscopy (SEM), Energy-Dispersive Spectroscopy (EDS), X-Ray diffraction (XRD) and micro-Raman analysis. The EDS quantitative and mapping analysis showed that for each investigated area, the identified elements were sulfur (S), arsenic (As), antimony (Sb) and tellurium (Te). These elements are present in constant atomic percentages on the entire sample, showing a good homogeneity of the samples. The study of samples by the above-mentioned methods showed the presence of crystalline phases and amorphous phases with the polycrystalline inclusions corresponding to the structural units AsS3, Sb2S3, and Sb2Те3.
10
Raval, Vishal, Randy Christopher Bowen, Hansell Soto, and Arun Singh. "Intravenous Chemotherapy for Retinoblastoma in the Era of Intravitreal Chemotherapy: A Systematic Review." Ocular Oncology and Pathology 7, no. 2 (December 16, 2020): 142–48. http://dx.doi.org/10.1159/000510506.
Full textAbstract:
<b><i>Purpose:</i></b> The published data on ocular survival following intravenous chemotherapy of retinoblastoma (RB) seems to be skewed by evolving practice patterns induced by use of intravitreal chemotherapy (iVitc). We aimed to explore potential role of iVitc for vitreous seeding for patients treated with intravenous chemotherapy (IVC). <b><i>Methods:</i></b> A literature search was performed to identify cases of RB treated with primary IVC prior to advent of iVitc by various search engines (PubMed, Medline, and Google) from 1992 to 2018. Studies were excluded if number of cases were less than 40 or lacked data related to type of recurrence and its treatment. Rates and patterns of recurrence and its management were categorized. <b><i>Results:</i></b> Out of 15 studies identified, only 10 studies (797 eyes) met the inclusion criteria. The mean age at presentation was 15.3 months (range 0–192.8 months). Unilateral cases represented 25% of the cohort. The ocular survival rate with primary IVC was 63% (500/797 eyes). Of the 297 eyes (37%) that failed IVC therapy, additional 99 eyes could be salvaged with EBRT (599/797 eyes, 75%). Remaining 198 eyes were enucleated (198/797 eyes 25%). K-M survival analysis could not be done due lack of sufficient data. Recurrences that occurred (mean 12.2 months) after completion of primary IVC included relapse of retinal tumor (143 eyes [48%]), vitreous seeding (73 eyes [25%]), subretinal seeding (49 eyes [16%]), or any combination (103 eyes [35%]). Out of 73 eyes with vitreous seeding, additional 66 eyes (90%) would have been salvaged with iVitc, potentially improving ocular survival rates to 71% (500 + 66/797). <b><i>Conclusions:</i></b> Evolving practice patterns of RB treatment have unfavorably skewed published ocular survival rates following IVC. With incorporation of iVitc, the ocular survival rates with IVC can be potentially improved to be non-inferior to those achieved with intra-arterial chemotherapy.
11
Bobykin, E. V., I. A. Kulakova, O. V. Morozova, and V. Ya Krokhalev. "Evaluation of the prevalence of silicone oil droplets in the vitreous in patients treated with multiple intravitreal drug injections." Acta Biomedica Scientifica 6, no. 5 (November 23, 2021): 126–35. http://dx.doi.org/10.29413/abs.2021-6.5.12.
Full textAbstract:
Background. At present, intraocular drops of silicone oil, which is a lubricant for disposable syringes used for intravitreal injections, are being actively studied. Among the undesirable effects of their presence are patient’s complaints of visual discomfort associated with floating opacities, as well as a potential connection with episodes of intraocular inflammation and increased intraocular pressure.The aim: to assess the prevalence of silicone oil droplets in the vitreous in patients treated with multiple intravitreal injections.Materials and methods. A single-center retrospective cohort study was carried out. Inclusion criterion: treatment with multiple (at least 5) intravitreal injections of drug solutions performed according to registered indications. The study group consisted of 86 eyes of 85 patients (56 women, 29 men; age – from 36 to 89 y.o., average – 71.7 y.o.), who received an average of 13.2 injections of solutions of various drugs.Results. Drops of silicone oil were detected by biomicroscopy in 57 eyes (66.28 %) and by ultrasonography in 76 (88.37 %). The coincidence of the results of applying the methods was recorded in 73.26 % of observations. Seven (8.1 %) patients had characteristic complaints. Four patients (4.7 %) had a history of aseptic vitreitis. The hypothesis was confirmed that the possibility of silicone oil droplets getting into the vitreous increases with the number of intravitreal injections. A similar relationship was established in relation to the possibility of the appearance of characteristic complaints in patients due to the presence of drops and episodes of aseptic vitreitis.Conclusion. The release of drops of silicone oil from syringes during intravitreal injections is an urgent problem that requires further study. In the Russian Federation, the situation is aggravated by the lack of prefilled syringes with drugs approved for administration into the eye cavity, as well as the lack of syringe models designed for use in ophthalmology.
12
Seibel, Ira, Daniela Vollhardt, Aline I. Riechardt, Matus Rehak, Sabine Schmied, Petra Schiller, Oliver Zeitz, Martin Hellmich, and Antonia M. Joussen. "Influence of Ranibizumab versus laser photocoagulation on radiation retinopathy (RadiRet) - a prospective randomized controlled trial." Graefe's Archive for Clinical and Experimental Ophthalmology 258, no. 4 (February 28, 2020): 869–78. http://dx.doi.org/10.1007/s00417-020-04618-7.
Full textAbstract:
Abstract Purpose To demonstrate superiority of intravitreal ranibizumab 0.5 mg compared to focal and peripheral laser treatment in patients with radiation retinopathy for choroidal melanoma. Methods Inclusion criteria were as follows: patients with radiation retinopathy and visual acuity impairment due to radiation maculopathy accessible for laser therapy, age ≥ 18 years, and BCVA less than 20/32. The main objective was to study the change in best-corrected visual acuity (BCVA) over 6 months from ranibizumab 0.5 mg (experimental) compared to focal laser of the macula and panretinal laser treatment of the ischemic retina (control) in patients with radiation retinopathy in choroidal melanoma. The secondary objectives of the radiation retinopathy study were to compare functional and anatomical results between ranibizumab and laser group over 12 months and to measure the frequency of vitreous hemorrhage and rubeosis iridis. Results The intention-to-treat analysis included 31 patients assigned to ranibizumab (n = 15) or laser treatment (n = 16). In terms of BCVA at month 6, ranibizumab was superior to laser treatment, with an advantage of 0.14 logMAR, 95% CI 0.01 to 0.25, p = 0.030. The positive effect of ranibizumab disappeared after treatment was discontinued. Similar results without statistically significant difference were found with respect to macular thickness. In both groups, no change was observed at month 6 in the size of ischemia in the macula or periphery compared to baseline. There was 1 case of vitreous hemorrhage in the laser group and no case of rubeosis iridis over time. Conclusions This study showed a statistically significant improvement in visual acuity and clear superiority of ranibizumab compared to laser treatment up to 26 weeks, but this effect disappeared at week 52 after completion of intravitreal treatment. Ranibizumab and PRP are considered equivalent in terms of the non-appearance of proliferative radiation retinopathy during the study. Trial registration EudraCT Number: 2011-004463-69
13
Riaz, Sidrah, Umair Tariq Mirza, Kashif Iqbal, Muhammad Tariq Khan, Khurram Azam Mirza, and Junaid Hanif. "The Common Indications of Pars plana vitrectomy (PPV) for posterior Segment Ocular diseases in patients from a Private Retina Clinic." Pakistan Journal of Medical and Health Sciences 15, no. 10 (October 30, 2021): 2759–62. http://dx.doi.org/10.53350/pjmhs2115102759.
Full textAbstract:
Purpose: To evaluate common indications and anatomical outcomes of PPV for posterior segment ocular diseases in patients presenting at private retina clinic in Lahore Study design: Cross sectional survey Methods and materials: Over the period of three years, from 1st April 2017 to 3oth April 2020, all patients fulfilling inclusion criterion, were included in study after approval from hospital ethical committee. After taking history and detailed ocular examination, diagnosis was confirmed by B scan or OCT, Hepatitis B & C screening done. The patient age, gender, laterality of eye, lens status, macular status, type of retinal pathology, type of anesthesia, procedure done and type of vitreous tamponade if used were noted. All procedures were performed by a single surgical team and patients were followed for six months for anatomical success or any complication. Data was analyzed by SPSS 25. Results: Out of 266 total patients, 168 (63.2%) were males and 98 (36.8%) were females. Right eye was involved in 125 (47%) and left in 141 (53%). Age range was from 2 years to 83years, mean age for males was 47.30, for females 48.07 years, median age was 50 years, mean age for GA was 30.62 years and 51.71 for LA patients. The highest incidences of posterior segment ocular problems were observed in patients with age range 51 to 60 years. The commonest indication for posterior segment surgery were RRD seen in 107 (40.23%), ROSO in 51 (19.17%) and vitreous hemorrhage 33 (12.41%). Endophthalmitis was indication in 20 (7.52%), dropped nucleus in 11 (4.13%), Macular hole in 7 (2.63%) and ERM in 3 (1.13%). Asteroid hyalosis, intraocular IOFB and diagnostic vitrectomy were least common indication, each seen in 1 (0.5%) patient. Silicon oil was most commonly used Endo tamponade used in 138 (51.88%) patients. All patients were followed for 6 months with vision and retinal status. All patients who underwent pars plana vitrectomy surgery were stable with anatomical success rate till 6 months postoperatively except 10 (3.76%) who required re do operation for retinal detachment or some other complications. Conclusion: Current practice in ophthalmology shows increased frequencies of internal approach (PPV) for vitreoretinal diseases rather external approach (SB). Silicon oil was most common internal tamponade used. Diabetic retinopathy was important cause of vitreous hemorrhage and TRD. Patients should be educated regarding regular fundoscopy and good systemic control of diabetes. Higher incidence of retinal detachment among all age groups needs awareness and education about its warning ocular symptoms. Key words: PPV (Pars plana vitrectomy), RRD (Rhegmatogenous retinal detachment), SB (Scleral buckling), TRD (Tractional retinal detachment), ROSO (removal of silicon oil), GA (general anesthesia), LA (local anesthesia)
14
Severo Bem Junior, Luiz, Gustavo De Souza Andrade, Joao Ribeiro Memória Júnior, and Hildo Rocha Cirne de Azevedo Filho. "Terson sign:." Jornal Memorial da Medicina 2, no. 1 (November 30, 2020): 38–43. http://dx.doi.org/10.37085/jmmv2.n1.2020.pp.38-43.
Full textAbstract:
Terson's sign (TS) is classically defined as vitreous hemorrhage associated with subarachnoid hemorrhage of aneurysmal origin, being an important predictor of severity, indicating greater morbidity and mortality when compared to patients without the sign. The objective of this study is to review the relationship of Terson syndrome/Terson sign with the prognosis of aneurysmal subarachnoid hemorrhage. A search for original articles, research and case reports was performed on the PubMed, Scielo, Cochrane and ScienceDirect platform, with the following descriptors: Terson sign and subarachnoid hemorrhage. Retrospective, prospective articles and case reports published in the last 5 years and which were in accordance with the established objective and inclusion criteria were selected. Ten (10) articles were selected, in which the available results show an unfavorable prognostic relationship of TS and subarachnoid hemorrhage, because these patients had a worse clinical status assessed on the Glasgow scales ≤ 8, Hunt & Hess > III, Fisher > 3, in addition to intracranial hypertension and location of the aneurysm in the anterior communicating artery complex. The early recognition of this condition described by Albert Terson in 1900 brought an important contribution to neurosurgery, being recognized until nowadays.
15
Kurnia, Denisa Anggi, and Neni Anggraini. "Efficacy and Safety Outcome Comparison of Endoresection and Proton Beam Therapy as Primary Treatment for Choroidal Melanoma." Ophthalmologica Indonesiana 46, no. 2 (August 26, 2020): 169. http://dx.doi.org/10.35749/journal.v46i2.100095.
Full textAbstract:
Objective: To evaluate and compare the efficacy and safety between endoresection and proton beam radiotherapy, as primary treatment in choroidal melanoma.Methods: Articles that were published from 2008 to 2018 were collected from multiple sources including Pubmed, Clinical Key, and Ophthalmology Advance. All study that comply with the inclusion and exclusion criteria were categorized based on level of evidence Oxford Center for Evidence-based Medicine Levels of Evidence. Primary outcome is secondary enucleation. Secondary outcomes are metastasis, recurrence, death, visual outcomes, and complication.
Result: Twelve articles were eligible to be reviewed. Mean secondary enucleation, metastasis, and death rate is lower in endoresection group (6.29% vs 12.94%; 8.00% vs 20.85%; 6.86% vs 20.43) while recurrence rate is lower in proton beam group (4.78% vs 6.86%). The most common complication that observed is retinal detachment. Other complications that were reported includes cataract formation, radiation retinopathy, neovascular glaucoma, vitreous hemorrhage, elevated intraocular pressure (IOP), iris neovascularization, and optic neuropathy.
Conclusion: Endoresection as primary treatment for choroidal melanoma shows better efficacy compared to proton beam therapy, regarding the ability to preserve the eyeball. The safety between endoresection and proton beam therapy, both therapy shows similar result.
16
Parveen, Shagufta, Saquib Naeem, Kashif Hanif, and Bushra Akbar. "Comparison of Nd: YAG (Neodymium-Doped Yttrium Aluminum Garnet) Laser Posterior Capsulotomy Techniques in The Treatment of Posterior Capsular Opacification." Pakistan Armed Forces Medical Journal 72, no. 1 (February 28, 2022): 164–68. http://dx.doi.org/10.51253/pafmj.v72i1.3697.
Full textAbstract:
Objective: To compare the safety and efficacy of different techniques of neodymium: yttrium-aluminum-garnet (Nd: YAG) laser posterior capsulotomy.
Study Design: Quasi-experimental study.
Place and Duration of Study: Combined Military Hospital Nowshera, from Aug 2015 to Mar 2017.
Methodology: A total of 120 patients fulfilling the inclusion criteria were allocated to three groups. Group-A (Circular-group, CG) patients were subjected to circular pattern capsulotomy, group-B (Hinged-group, HG) patients underwent hinged pattern capsulotomy and group-C (Modified-group, MG) had a circular pattern of Nd: YAG posterior capsulotomy along with vitreous strand cutting (modified round pattern). Primary outcome measures were the best-corrected visual acuity (BCVA), intraocular pressure (IOP) and annoying floaters at three-months follow up visits.
Results: The mean age of patients was 52.27 ± 5.65 years and there were 64 (53.3%) males and 56 (46.7%) females. The bestcorrected visual acuity improved significantly (p<0.001) in the modified round pattern group compared to the other two groups at two weeks post-capsulotomy. Intraocular pressure remained unchanged among the three groups. Significantly fewer patients in the modified treatment-group experienced annoying floaters as compared to hinged and circular treatment groups [3 (7.5%) vs 9 (22.5%) vs 12 (30.0%) respectively, p=0.038].
Conclusion: Modified round pattern Nd: YAG laser posterior capsulotomy is a safe and effective method for treating posterior capsular opacification.
17
Giri, Puspa, Sudha Ranabhat, Gopal Bhandari, and Ranjeet Sah. "Indications and Visual Outcome in Patients Undergoing Penetrating Keratoplasty." Journal of Nobel Medical College 11, no. 2 (December 31, 2022): 16–21. http://dx.doi.org/10.3126/jonmc.v11i2.50438.
Full textAbstract:
Background: Penetrating keratoplasty is commonly performed surgery in patients suffering from corneal blindness and visual impairment, where full thickness diseased cornea is replaced with healthy cornea. This study aims to outline indications of Penetrating keratoplasty and visual outcomes following the procedure.
Materials and Methods: This retrospective, hospital-based study included 48 eyes of 48 subjects fulfilling inclusion criteria and underwent Penetrating keratoplasty from January 2017-2020 at Bharatpur Eye Hospital. General ophthalmologic examination was done preoperatively and postoperatively. Indication of the surgery along with demographic outline and requisite investigations were performed.
Results: Mean age of the subjects was 47±1.83 years (13-74 years) where most of them were in 61-70years (23%) age group. Male subjects were more (62.5%) compared to females. Triple procedure was performed in 6.25 percent of patients. The most common indication was infective keratitis (52%) followed by corneal opacity/ scarring, regrafts, keratoconus and bullous keratopathy. Penetrating keratoplasty was performed slightly more for therapeutic purpose (52%) than optical. Intraoperative complications were observed in 16.7% of patients, positive vitreous pressure being the sole cause. Ameliorated visual acuity was observed in 71% of patients with43.75% of patients having VA of ≥3/60
Conclusion: Infective keratitis was the predominant indication followed by corneal opacity/ scarring. Penetrating keratoplasty helps in maintaining integrity of the globe along with restoration of vision
18
Geiger, Tobias, Hartmut Gerhards, Bogdan Bjelica, Elke Mackenthun, and Bettina Wollanke. "Analysis of 1840 Equine Intraocular Fluid Samples for the Presence of Anti-Leptospira Antibodies and Leptospiral DNA and the Correlation to Ophthalmologic Findings in Terms of Equine Recurrent Uveitis (ERU)—A Retrospective Study." Veterinary Sciences 9, no. 8 (August 21, 2022): 448. http://dx.doi.org/10.3390/vetsci9080448.
Full textAbstract:
In the equine clinic of the LMU in Munich, therapeutic vitrectomies have been routinely performed in horses for three decades. The vitreous samples obtained during vitrectomies were usually tested for anti-Leptospira antibodies and for more than 20 years also by PCR for leptospiral DNA. If the indication for surgery was ophthalmologically inconclusive, an aqueous humor was collected preoperatively and examined for evidence of leptospiral infection. In this study, medical records from 2002 to 2017 were analyzed. Records for 1387 eyes affected by equine recurrent uveitis (ERU) and 237 eyes affected by another type of uveitis met the inclusion criteria. A total of 216 samples from healthy eyes were used as controls. In 83% of intraocular samples from ERU eyes, antibody titers of 1:100 or higher were detectable by microscopic agglutination test (MAT). Similarly, 83% of intraocular samples had anti-Leptospira antibodies detected by ELISA. In 72% of the intraocular specimens, leptospiral DNA was detectable by PCR. No antibodies were detectable in the samples from eyes with another type of uveitis or in the samples from healthy eyes. A PCR was positive in only one sample from a healthy eye. These results with a very high number of intraocular specimens demonstrate the great importance of an intraocular leptospiral infection for ERU. It can be concluded that for a reliable diagnosis of intraocular leptospiral infection or to reliably exclude an infection multiple tests should be applied.
19
Wang, Ling, Gang Yin, Zhiying Yu, Nan Chen, and Dabo Wang. "Effect of Hemodialysis on Eye Coats, Axial Length, and Ocular Perfusion Pressure in Patients with Chronic Renal Failure." Journal of Ophthalmology 2018 (2018): 1–6. http://dx.doi.org/10.1155/2018/3105138.
Full textAbstract:
Purpose. To investigate changes in eye coats, axial length, and ocular perfusion pressure (OPP) in hemodialysis (HD) patients with chronic renal failure (CRF). Methods. We included HD patients who were diagnosed with CRF in our hospital from January to December 2015. Fifty-two patients met the inclusion criteria; all right eyes were used for observation. Systolic and diastolic blood pressures were recorded to calculate OPP. Approximately 30 minutes before and after HD, we recorded multiple parameters, including lens thickness (LT), axial length of vitreous (VAL), axial length of eye (EAL), ciliary body thickness (CBT), choroidal thickness (CT), and retinal thickness (RT). Results. After HD, OPP significantly decreased (P<0.01, F=7.023) and CBT became significantly thinner (P<0.01, t=3.461). CT was significantly thinner and differed among measurement locations (P<0.01, t=6.240; P<0.01, t=6.169; P<0.01, t=3.405, respectively, fovea, nasal, and temporal side 1500 μm beside the fovea). Further, RT thickened and differed among measurement locations (P<0.05, t=−2.265; P<0.05, t=−2.624; P<0.05, t=−2.220, respectively, fovea, nasal, and temporal side 1500 μm beside fovea), whereas LT, VAL, and EAL significantly increased after HD (P<0.05, t=−2.076; P<0.01, t=−3.817; P<0.01, t=−4.010). Conclusions. HD impacts the thickness of the eye coats and VAL, particularly affecting CBT, CT, and RT. OPP transiently decreases during HD, which may contribute to an ischemic state.
20
Štubňa, Ján, Peter Bačík, Jana Fridrichová, Radek Hanus, Ľudmila Illášová, Stanislava Milovská, Radek Škoda, Tomáš Vaculovič, and Slavomír Čerňanský. "Gem-Quality Green Cr-Bearing Andradite (var. Demantoid) from Dobšiná, Slovakia." Minerals 9, no. 3 (March 8, 2019): 164. http://dx.doi.org/10.3390/min9030164.
Full textAbstract:
Andradite, variety demantoid, is a rare gem mineral. We describe gem-quality garnet crystals from serpentinized harzburgites from Dobšiná, Slovakia which were faceted. Both the andradite samples were transparent, with a vitreous luster and a vivid green color. They were isotropic with refractive indices >1.81. The measured density ranged from 3.82 to 3.84 g·cm−3. Andradite var. demantoid appeared red under Chelsea filter observation. Both samples contained fibrous crystalline inclusions with the typical “horsetail” arrangement. The studied garnet had a strong Fe3+ dominant andradite composition with 1.72–1.85 apfu Fe3+, Cr3+ up to 0.15 apfu, Al3+ 0.03 to 0.04 apfu, V3+ up to 0.006 apfu substituted for Fe3+, Mn2+ up to 0.002 apfu, and Mg up to 0.04 apfu substituted for Ca. Raman spectrum of garnet showed three spectral regions containing relatively strong bands: I—352–371 cm−1, II—816–874 cm−1, and III—493–516 cm−1. The optical absorption spectrum as characterized by an intense band at 438 nm and two broad bands at 587 and 623 nm and last one at 861 nm, which were assigned to Fe3+ and Cr3+. Transmission was observed in the ultraviolet spectral region (<390 nm), near the infrared region (700–800 nm), and around 530 nm in the green region of visible light, resulting in the garnet’s green color.
21
Rahman, Rubina, Ajay Patil, and John Stephenson. "The Incidence of Retinal Breaks Induced by Posterior Hyaloid Separation During 27-Gauge Pars Plana Vitrectomy." Journal of VitreoRetinal Diseases 3, no. 2 (March 2019): 76–79. http://dx.doi.org/10.1177/2474126419831908.
Full textAbstract:
Purpose: As advances are made in smaller-gauge vitrectomy, it is important to characterize the associated risks. This allows the surgeon to anticipate complications and appropriately counsel patients. The incidence of iatrogenic retinal breaks in 25- and 23-gauge (G) vitrectomy is known, but no studies exist looking at the incidence in 27G vitrectomy with an attached posterior hyaloid face (PHF). This study set out to characterize the incidence. Methods: A retrospective, consecutive, observational study of patients undergoing 27G transconjunctival sutureless vitrectomy for macular pathology or floaters was conducted. This was a single-surgeon series conducted between 2015 and 2017 at Calderdale Royal Hospital, United Kingdom. Inclusion criteria included only those with an attached PHF at the disc, identified intraoperatively. Results: Data were collected and analyzed in 94 patients. Preoperative diagnosis frequency was as follows: epiretinal membrane 24 (25.5%), macular hole 47 (50.0%), vitreomacular traction 11 (11.7%), and floaters 12 (12.8%). In 82 out of 94 patients (89.1%), 27G vitrectomy was combined with 2.2 mm microincisional phacoemulsification with lens implantation. The incidence of iatrogenic retinal breaks associated with PHF separation during 27G PPV was 17% (16 cases). Conclusions: This is the first study to report the incidence of peripheral retinal breaks induced by PHF separation during 27G vitrectomy. Our single-surgeon case series of 27G PPV for all elective vitreoretinal indications, in eyes with attached vitreous, yielded an iatrogenic break rate of 17%. However, no postoperative retinal detachments followed. Statistical analysis revealed no specific risk factors to be significantly associated with outcome (incidence of retinal tear).
22
Sisca, Sisca, Nurul Azizah, and M. Salas Al Aldi. "POTENSIAL MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES (MSC-EVS) SEBAGAI TERAPI TERBARU DALAM OBAT ISKEMIK RETINAL." Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran 1, no. 2 (August 30, 2018): 65–73. http://dx.doi.org/10.26618/aimj.v1i2.2756.
Full textAbstract:
Retinal ischemia (IR) is still the biggest cause of blindness in the world. Several factors contribute to the pathogenesis of Retinal Ischemia. However, oxidative stress and inflammatory processes are the main factors. Various forms of therapy have been applied in clinical care of Retinal ischemia, but none have been optimal for repairing the cells damage and able to avoid immunological and oncogenic reactions. MSC-EVs have opened a new perspective for the treatment of Retinal Ischemia. MSC is a multipotent cell with paracrine characteristic and mediated by extracellular vesicles (EVs) which is derivative of MSC that can be used as a biomimetic agent to help nerve protection and tissue regeneration. In addition, MSC-EVs have a lower tendency to trigger immune responses and the inability to directly form tumors. Therefore, MSC EVs can prove to be an ideal source for the latest therapies in dealing with the problem of retinal ischemia. This Literature Riview is compiled by using a literature study with collecting valid journals, particular inclusion and exclusion criteria. On testing its effectiveness, three indicators were used, that is the protective effect of MSC-EVs on retinal cells, the effects of post-ischemic in vivo administration of MSC-EVs, and the distribution of MSC-EVs in humour vitreous and long-term protective effects estimates. Significantly shows a protective effect, decreases inflammatory factors and apoptosis of retinal cells. Based on the results of testing in vitro and in vivo MSC-EVs are endocytosis by retinal cells that provide neuroprotective effects before and after treatment, and this effect can be developed into long-term therapy. Therefore, using MSC-EVs can be a promising therapy in the treatment of retinal ischemia.
23
Pham, Tony, Caitlin Young, Noel Woodford, David Ranson, Carmel M. F. Young, and Joseph E. Ibrahim. "Difference in the characteristics of mortality reports during a heatwave period: retrospective analysis comparing deaths during a heatwave in January 2014 with the same period a year earlier." BMJ Open 9, no. 5 (May 17, 2019): e026118. http://dx.doi.org/10.1136/bmjopen-2018-026118.
Full textAbstract:
ObjectivesTo describe the characteristics of deaths reported to the Coroners Court of Victoria (CCOV) during Victoria’s last heatwave (14–17 January 2014) and subsequent 4 days (18–21 January) using medicolegal data obtained from both the police investigation report and the pathologist’s report.Design, setting and participantsA single-jurisdiction population-based retrospective analysis of consecutive heat-related deaths (HRDs) reported to the CCOV between 14 and 21 January 2014 with a historical comparison group.Main outcome measuresDescriptive statistics were used to summarise case demographics, causes of death and the types of investigations performed. The cases from 2014 were subgrouped into HRD and non-HRD.ResultsOf the 222 cases during the study period in 2014, 94 (42.3%) were HRDs and 128 (57.7%) were non-HRDs. HRDs were significantly older than non-HRDs (70.5 years: SD=13.8 vs 61.0 years: SD=22.4, t(220)=3.60, p<0.001, 95% CI 4.3 to 14.6). The most common primary cause of death in HRDs was circulatory system disease (n=57, 60.6%), which was significantly higher when compared with non-HRDs (n=39, 30.5%; χ2=20.1, p<0.001, OR 3.5, 95% CI 2.0 to 6.2). HRDs required significantly greater toxicology investigation (89.4% (n=84) vs 71.9% (n=92); χ2=10.9, p<0.001, OR 3.3, 95% CI 1.54 to 7.03) and greater vitreous biochemistry testing (40.4% (n=38) vs 16.4% (n=21); χ2=16.0, p<0.001, OR 3.5, 95% CI 1.9 to 6.5).ConclusionsA heatwave places a significant burden on death investigation services. The inclusion of additional laboratory tests and more detailed circumstantial information are essential if the factors that contribute to HRDs are to be identified.
24
Cobert, Julien, Ephraim P. Hochberg, Jeremy S. Abramson, Christiana E. Toomey, and Fred H. Hochberg. "Nervous System Invasion Occurs in 4% Percent of Chronic Lymphocytic Leukemia." Blood 112, no. 11 (November 16, 2008): 4200. http://dx.doi.org/10.1182/blood.v112.11.4200.4200.
Full textAbstract:
Abstract Introduction: Chronic Lymphocytic Leukemia (CLL) is a low-grade B-cell lymphoma that manifests as high white blood cell counts and lymphadenopathy. Current clinical paradigms for the care of CLL do not include evaluation or prophylaxis of the central nervous system. Four percent of our patients with CLL developed neurologic manifestations which approximates the 3–7% risk of CNS involvement in large series of diffuse large B cell lymphoma (DLBCL). We found that the majority of these cases had no evidence of histologic Richter’s transformation. Our experience confirms prior anecdotal reports of involvement of the central nervous system by CLL which have described: abnormal lymphocytes in the CSF or vitreous, MRI dural enhancement, enhancement within the spinal cord or cranial/peripheral nerves, orbital mass, PML-like diffuse white matter abnormalities of brain (without the presence of JC virus DNA) and/or Richter’s transformation in the nervous system. Methods: A CLL medical records review protocol was approved by the Dana Farber Harvard Cancer Center Institutional Review Board. Using our clinical lymphoma database we collected records of 755 patients at Massachusetts General Hospital (MGH) Cancer Center who carried a diagnosis of CLL from January 1988 to August 2008. We will present the neurologic involvement identified by restricting cases to those with the following diagnostic studies: patients who had received brain, head or spine MRIs, patients who had received lumbar punctures or post-mortem examinations. We also included any patient with brain, nerve (peripheral or otherwise) and/or orbital biopsies. Within this cohort, 30 patients were found with the following sites of predominant neurological involvement of CLL: dural infiltration (2), CSF infiltration by cytology or flow cytometry (6), infiltration of peripheral nerve, optic nerve or spinal nerve roots (6), ocular involvement of the vitreous or conus (7), Richter’s transformation into primary CNS DLBCL (6), and diffuse non-enhancing white matter abnormalities without the presence of JC virus (3). Many patients presented with multiple neurological sites of disease. Discussion: Recognition of the risk of central nervous involvement in DLBCL has led to a new paradigm of CNS prophylaxis in high risk patients. Our estimate of 3.97% involvement of the nervous system with CLL likely underestimates the true risk of this fatal complication for the following reasons. We did not directly examine patient records for neurologic symptoms. We did not re-evaluate the cytology of CLL patients whose neurologic symptoms prompted a negative lumbar puncture nor neuro-pathology specimens of autopsied CLL patients with negative gross involvement. Patients who were diagnosed with CLL at MGH but who had their neurologic studies performed outside of our electronic medical record (EMR) system are clearly not included in our numerator. Current CLL therapies have limited CNS penetration. Our risk estimate, if confirmed, will stimulate the inclusion of neur-axis penetrating agents into CLL therapy in high-risk patients.
25
Patil, Mrunal Suresh, Dhiraj Namdeo Balwir, and Swapnil Vidhate. "A Study of Nd:YAG Laser Capsulotomy in the Management of Posterior Capsular Opacification." MVP Journal of Medical Sciences 3, no. 1 (March 1, 2016): 18. http://dx.doi.org/10.18311/mvpjms/2016/v3/i1/718.
Full textAbstract:
<strong>Aims:</strong> To study the visual outcome following Nd:YAG laser posterior capsulotomy and to study the complications associated with Nd:YAG laser posterior capsulotomy. <strong>Material and Methods:</strong> The study included a total of 100 eyes of 100 patients who fulfilled the inclusion and exclusion criteria. Once diagnosed to have posterior capsular opacification they were subjected to a detailed clinical examination. All patients underwent Nd:YAG laser capsulotomy. Patients were followed up at 1 hour, 4 hour, 1 day, 1 week, 1 month, 3 month. At every follow up detailed examination was done. BCVA and any complications were noted. <strong>Results:</strong> Post-laser, 87% patients had BCVA 6/12 or more at 3 month follow up. 10% patients had BCVA 6/24 to 6/18. Only 3% patients had visual acuity improved to less than 6/24. Out of 3 patients, 1 patient had visual acuity improved to 6/60&in remaining 2 visual acuity improved to 6/36. The complications were seen in 31 (31%) patients. Most common complication observed was transient rise in IOP. 17 eyes (17%) had transiently raised IOP. Second most common noted was pitting of IOL. Pitting was present in 7 (7%) patients, 3 (3%) patients had ruptured anterior face of vitreous, 2 (2%) patients had iritis, 1 (1%) had hyphema and 1 (1%) developed CME. IOP rise was related to grade of PCO and energy used.<strong> Conclusion:</strong> Improvement in visual acuity after Nd:YAG laser posterior capsulotomy is excellent. Complications associated with Nd:YAG laser capsulotomy are minimal. Nd: YAG laser capsulotomy is a safe method of restoring vision in patients with posterior capsule opacification.
26
Joshi, Nisarg P., Murtaza K. Adam, Wasim A. Samara, Abtin Shahlaee, Ehsan Rahimy, Christopher M. Aderman, Jason Hsu, Mitchell S. Fineman, and Sunir J. Garg. "Optical Density of Subretinal Fluid as a Predictive Biomarker for Eyes With Chronic Central Serous Retinopathy Treated With Eplerenone." Journal of VitreoRetinal Diseases 2, no. 1 (December 8, 2017): 6–11. http://dx.doi.org/10.1177/2474126417746462.
Full textAbstract:
Purpose: To investigate how the optical density ratio (ODR) of subretinal fluid (SRF) obtained by optical coherence tomography (OCT) in eyes with chronic central serous retinopathy (CSR), defined as symptoms >3 months, treated with eplerenone correlates with treatment response and visual outcomes. Methods: This retrospective, single-center observational study included patients with chronic CSR treated with eplerenone who had at least 6 weeks of follow-up. Eyes with poor-quality OCT scans, shallow SRF precluding sampling of optical density (OD), and macular pathology other than CSR were excluded. Optical density of the vitreous and SRF was measured using ImageJ and used to calculate ODR (ODR = ODSRF/ODVIT). Peak SRF height, foveal SRF height, central macular thickness (CMT), and Snellen visual acuity (VA) were measured. The Mann-Whitney U test was used to compare continuous variables. Pearson correlation coefficient was used to determine the statistical significance of applied linear regressions. Results: Twenty-three eyes of 23 patients met the inclusion criteria. Six (26%) eyes had complete resolution of foveal SRF (resolvers) with eplerenone treatment, and the remainder of patients had worsening or incomplete resolution (nonresolvers). Resolvers had significantly lower baseline logarithm of the minimum angle of resolution (logMAR) VA ( P < .01) than nonresolvers. There was a positive linear correlation between ODR and logMAR VA at baseline ( R2 = 0.208; P = .03) and follow-up ( R2 = 0.206; P = .03). A significant correlation between ODR and percentage change in CMT was found ( R2 = 0.263; P = .01). Linear correlations were not found between ODR and age, peak SRF height, and foveal SRF height (all P > .125). Conclusion: Lower baseline ODR was associated with improved percentage change in CMT and VA in patients treated with eplerenone for chronic CSR. Optical density ratio may represent a novel prognostic biomarker that may help determine which eyes with chronic CSR may respond better to eplerenone.
27
Tatke, Akshaya, Narendar Dudhipala, Karthik Janga, Sai Balguri, Bharathi Avula, Monica Jablonski, and Soumyajit Majumdar. "In Situ Gel of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles for Improved Topical Ocular Delivery: Tear Kinetics and Ocular Disposition Studies." Nanomaterials 9, no. 1 (December 27, 2018): 33. http://dx.doi.org/10.3390/nano9010033.
Full textAbstract:
Triamcinolone acetonide (TA), an intermediate acting corticosteroid, is used in the treatment of posterior ocular diseases, such as inflammation, posterior uveitis, and diabetic macular edema. The objective of this investigation was to prepare TA-loaded solid lipid nanoparticles (TA-SLNs) and in situ gel (TA-SLN-IG) formulations for delivery into the deeper ocular tissues through the topical route. TA-SLNs were prepared by hot homogenization and ultrasonication method using glyceryl monostearate and Compritol® 888ATO as solid lipids and Tween®80 and Pluronic® F-68 as surfactants. TA-SLNs were optimized and converted to TA-SLN-IG by the inclusion of gellan gum and evaluated for their rheological properties. In vitro transcorneal permeability and in vivo ocular distribution of the TA-SLNs and TA-SLN-IG were studied using isolated rabbit corneas and New Zealand albino rabbits, respectively, and compared with TA suspension, used as control (TA-C). Particle size, PDI, zeta potential, assay, and entrapment efficiency of TA-SLNs were in the range of 200–350 nm, 0.3–0.45, −52.31 to −64.35 mV, 70–98%, and 97–99%, respectively. TA-SLN-IG with 0.3% gellan gum exhibited better rheological properties. The transcorneal permeability of TA-SLN and TA-SLN-IG was 10.2 and 9.3-folds higher compared to TA-C. TA-SLN-IG showed maximum tear concentration at 2 h, indicating an improved pre-corneal residence time, as well as higher concentrations in aqueous humor, vitreous humor and cornea at 6 h, suggesting sustained delivery of the drug into the anterior and posterior segment ocular tissues, when compared to TA-SLN and TA-C. The results, therefore, demonstrate that the lipid based nanoparticulate system combined with the in situ gelling agents can be a promising drug delivery platform for the deeper ocular tissues.
28
Lei, Chunyan, Keren Zhang, Tiancong Chang, Qibo Ran, and Meixia Zhang. "Relationship between renal function and prognosis of Chinese proliferative diabetic retinopathy patients undergoing the first vitrectomy: protocol for a prospective cohort study." BMJ Open 11, no. 12 (December 2021): e052417. http://dx.doi.org/10.1136/bmjopen-2021-052417.
Full textAbstract:
IntroductionChina has the largest number of adults with diabetes aged 20–79 years (116.4 million) in 2019. Due to the socioeconomic condition or a lack of awareness of diabetic complications, many adults with diabetes have proliferative diabetic retinopathy (PDR) or renal function impairment at their first visit to the clinic for a sudden loss of vision, and pars plana vitrectomy (PPV) is required for their treatment. Risk factors for the outcomes and complications of PPV surgery in PDR patients have been widely explored in many epidemiological studies and clinical trials. However, few prospective studies have analysed the association between renal function and surgical outcomes in PDR.Methods and analysisThis is a single-centre, prospective cohort study of PDR patients with type 2 diabetes mellitus who have definite indications for PPV surgery with or without renal function impairment. We will consecutively enrol PDR patients who meet the inclusion and exclusion criteria from November 2020 to December 2023. Each participant will be followed up for at least 6 months after surgery. Clinical data from medical records and vitreous fluid will be collected.Demographic characteristics and study outcomes will be summarised using descriptive statistics. The variation will be described and evaluated using the χ² test or Kruskal-Wallis test. Generalise additive mixed models will be used to explore the association between the renal profile and surgical outcomes including BCVA, and retinal and choroidal microvasculature/microstructure. Multivariate ordinal regression analysis will be used to detect the independent association between renal profile and BCVA changes, and smooth curve fitting will be employed to briefly present the tendency.Ethics and disseminationThe trial has received ethical approval from the West China Hospital of Sichuan University. Results of this trial will be disseminated through publication in peer-reviewed journals and presentations at local and international meetings.Trial registration numberChiCTR2000039698.
29
Chattannavar, Goura, Ashik Mohamed, Vishwesh Malgi, and Ramesh Kekunnaya. "Visual outcomes and safety profile of intraocular lens implantation versus aphakia in children with microspherophakia with no subluxation." BMJ Open Ophthalmology 8, no. 1 (January 2023): e001049. http://dx.doi.org/10.1136/bmjophth-2022-001049.
Full textAbstract:
ObjectiveTo study the visual, refractive and surgical outcomes of intraocular lens (IOL) implantation versus aphakia in children with microspherophakia.DesignRetrospective, comparative, non-randomised interventional study.MethodsAll consecutive children with microspherophakia who satisfied the inclusion criteria were included. The eyes that underwent in-the-bag IOL implantation and those that were left aphakic were included in groups A and B, respectively. The postoperative visual outcomes, IOL stability and complications during the follow-up period were studied.Results22 eyes (13 patients, male 76%), of which 12 eyes were in group A and 10 eyes in group B. The mean±SE of age at surgery was 9.4±1.4 and 7.3±0.9 years in group A and group B, respectively (p value 0.18). The mean follow-up of group A was 0.9±0.4 years (median 0.5 years; Q1 0.04, Q3 2.16) and group B was 1.3±0.9 years (median 0.147 years; Q1 0.08, Q3 0.39) (p value 0.76). All the baseline biometric variables including best-corrected visual acuity (BCVA) were comparable in each group. The final BCVA in logMAR adjusted for follow-up was comparable in both group A (0.29±0.06) and group B (0.52±0.09) (p value 0.06). Mean predictive error of IOL power in microspherophakia was 0.17±0.43.The most common complication in group A was visual axis opacification of two eyes (16.7%, 95% CI 2.9% to 49.1%), of which one eye (8.3%, 95% CI 0.4% to 40.2%) needed membranectomy. Vitreous in anterior chamber was the most common complication in group B, seen in two eyes (20%, 95% CI 3.5% to 55.8%), of which one eye (10%, 95% CI 0.5% to 45.9%) underwent YAG laser vitreolysis. The survival analysis (p value 0.18) was comparable in each group.ConclusionIn-the-bag IOL is an option, which can be considered in selected cases of microspherophakia in developing nations where regular follow-up and economic constraints are a major concern.
30
Sheikhi Gheshlaghi, Rasoul, Mansour Ghorbani, Ali Asghar Sepahi, Reza Deevsalar, Kazuo Nakashima, and Ryuichi Shinjo. "The origin of gem spodumene in the Hamadan Pegmatite, Alvand Plutonic Complex, western Iran." Canadian Mineralogist 60, no. 2 (March 1, 2022): 249–66. http://dx.doi.org/10.3749/canmin.2000087.
Full textAbstract:
ABSTRACT Pegmatite bodies with a simple mineral composition are widespread within the Sanandaj-Sirjan Zone (SaSiZ), Zagros Orogen, Iran; however, gem-bearing pegmatite bodies are rare. There is a pegmatitic vein within the Hamadan garnet (± andalusite ± staurolite) schist adjacent to the Alvand Plutonic Complex (APC), south of Hamedan city (western Iran), in which large crystals of gem spodumene occur together with quartz, amazonite, beryl, tourmaline, and apatite. This spodumene-bearing pegmatite consists of four major zones with slightly different mineral compositions from the border to the core. The wall zone of quartz-rich granitoid and the intermediate zone of alkali granite have trondhjemitic compositions near the quartzolitic gem-bearing core zone. All parts of the vein are peraluminous in composition and exhibit S-type affinity. Two types of spodumene which have been distinguished in the core zone are colorless to very pale yellow and pink, transparent with vitreous luster and inclusion-free (eye clean) under 10× magnification. The different color in these minerals can be attributed to the slightly different chemical compositions, particularly lower Fe/Mn ratios in the pink material. The δ7Li values of the spodumene (+5.58 to +6.57‰) are indicative of the incorporation of middle continental crustal components in their genesis. Change in the mineral assemblage from tourmaline-bearing in the intermediate zone to spodumene + tourmaline in the core zone of the spodumene-bearing pegmatite is consistent with increasing lithium content from the wall zone to the core. Petrographic, geochemical, and isotopic data indicate that partial melting of middle-crustal Al-rich metapelitic source was followed by fractional crystallization to generate these rocks. In this concern, the required Li for the crystallization of spodumene was probably supplied by the breakdown of staurolite of the Hamadan schist and/or subsequent fractional crystallization of the parent magma. The results also demonstrate that the regional tectonic regime exerts a primary control on the occurrence and emplacement of the miarolitic pegmatite in the upper crust and the formation of gem spodumene during late-stage magmatic activities.
31
Egorov, A. V., O. V. Kolenko, V. V. Egorov, and G. P. Smoliakova. "Prospects modern pharmacotherapy in postoperative rehabilitation of patients after endovitreal surgery of rhegmatogenous retinal detachment." Fyodorov journal of ophthalmic surgery, no. 2 (July 15, 2021): 19–24. http://dx.doi.org/10.25276/0235-4160-2021-2-19-24.
Full textAbstract:
Purpose. To assess increasing the functional effectiveness of the results of endovitreal surgery in patients with rhegmatogenous retinal detachment (RRD) by using modern pharmacotherapy drug in the postoperative rehabilitation. Materials and methods. 108 people (108 eyes) with RRD. All patients underwent standard three-port vitrectomy, after which tamponade of the vitreous cavity with silicone oil with its removal 3 months after operation was performed. Patients were divided into 2 groups: the first – 60 people who received Cytoflavin on the background of standard therapy, and the second – 48 people with postoperative treatment only with standard therapy. Depending on the visual prognosis calculated before the operation, both groups were represented patients with satisfactory (A subgroup) and low (B subgroup) visual prognosis. Laser Doppler fluometry (LDF) was used to study chorioretinal microcirculation: microcirculation index and microcirculation efficiency index were recorded. Using OCT angiography (OCT-A), signs of macular ischemia were investigated: choroidal thickness, area nonperfusion of foveal avascular zone, density in the superficial capillary plexuses and density in the deep capillary plexuses in the macular area. Results. The inclusion of Cytoflavin in the postoperative rehabilitation of patients with RRD increases the possibility of a favorable functional outcome of the operation, affects the positive dynamics in the state of the capillary plexus in the macula. In the aggregate of patients of the 1st group, the increase in visual acuity was 2 times higher than in patients of the 2nd group 6 months after surgery. Also, in patients of the 1st group there was a more significant activation of chorioretinal blood flow according to LDF and OCT-A. Conclusion. The prescription of Cytoflavin in the postoperative treatment of patients underwent endovitreal surgery of RRD, regardless of the visual prognosis, increases the functional outcome of the operation. Improvement in visual functions in patients receiving Cytoflavin therapy is directly related to improved intraocular blood flow and macular perfusion. Keywords: rhegmatogenous retinal detachment, chorioretinal microcirculation, ocular hemodynamics, Laser Doppler fluometry, optical coherence tomography angiography, Cytoflavin.
32
Hamal, Diwa, Ben Limbu, Purnima Rajkarnikar Sthapit, Eli Pradhan, Reshmi Shrestha, and Rohit Saiju. "Choroidal Melanoma: Our Experience." Nepalese Journal of Ophthalmology 11, no. 1 (September 2, 2019): 64–73. http://dx.doi.org/10.3126/nepjoph.v11i1.25422.
Full textAbstract:
Background: Choroidal melanomas are diagnosed in approximately 6 out of one million Americans per year, and although their incidence is low, they are the most common primary intraocular tumor in adults.
Methods: Choroidal melanoma is rare tumors and till date no such reports with sclera involvement has been reported from Nepal. It is a prospective case series. The aim of this study is for awareness of the severity of the Choroidal melanoma and it’s management. Besides, it is also to study the demography, presentation, histopathological variations and management of cases of choroidal melanoma. All the consecutive cases of Choroidal melanoma presenting between Jan 2017 to May 2018 and those who were within the inclusion criteria were included in this study.
Results: There were eight patients, five male and three female, within age range of 18-73, median age was 47. All patients presented with decreased vision ranging from 6/24 to PL of less then three months to 2 years duration. Fund us showed choroidal mass associated with Vitreous hemorrhage (VH), and retinal detachment (RD). Two patients were managed with enucleation with External beam radiotherapy (EBRT). Four underwent only enucleation. One patient with lesion size less then 10mm under went plaque brachy therapy. One patient underwent initially Plaque brachy therapy but later had to undergo Enucleation. Histopathological examination (HPE) of enucleated patient revealed epitheloid cell melanoma grade three in four and Spindle cell melanoma in three patients. Each one patient of epitheloid cell melanoma and spindle cell melanomahad scleral involvement. Indication for radiotherapy was scleral involvement.
Conclusion: With 8 cases of Choroidal melanoma in a single year in a single hospitalgives us a clue that there may be much more undiagnosed cases of Choroidal melanomain Nepal that should be taken seriously. Going for annual eye examination with routine dilated fund us exams can help in prevention and early diagnosis of this life and sight threatening condition and to reduce the mortality rate.
33
Moscati, R. J., and C. A. Johnson. "Major element and oxygen isotope geochemistry of vapour-phase garnet from the Topopah Spring Tuff at Yucca Mountain, Nevada, USA." Mineralogical Magazine 78, no. 4 (August 2014): 1029–41. http://dx.doi.org/10.1180/minmag.2014.078.4.14.
Full textAbstract:
AbstractTwenty vapour-phase garnets were studied in two samples of the Topopah Spring Tuff of the Paintbrush Group from Yucca Mountain, in southern Nevada. The Miocene-age Topopah Spring Tuff is a 350 m thick, devitrified, moderately to densely welded ash-flow tuff that is zoned compositionally from high-silica rhyolite to latite. During cooling of the tuff, escaping vapour produced lithophysae (former gas cavities) lined with an assemblage of tridymite (commonly inverted to cristobalite or quartz), sanidine and locally, hematite and/or garnet. Vapour-phase topaz and economic deposits associated commonly with topaz-bearing rhyolites (characteristically enriched in F) were not found in the Topopah Spring Tuff at Yucca Mountain. Based on their occurrence only in lithophysae, the garnets are not primary igneous phenocrysts, but rather crystals that grew from a F-poor magmaderived vapour trapped during and after emplacement of the tuff. The garnets are euhedral, vitreous, reddish brown, trapezohedral, as large as 2 mm in diameter and fractured. The garnets also contain inclusions of tridymite. Electron microprobe analyses of the garnets reveal that they are almandinespessartine (48.0 and 47.9 mol.%, respectively), have an average composition of (Fe1.46Mn1.45Mg0.03Ca0.10)(Al1.93Ti0.02)Si3.01O12and are comparatively homogeneous in Fe and Mn concentrations from core to rim. Composited garnets from each sample site have δ18O values of 7.2 and 7.4%. The associated quartz (after tridymite) has δ18O values of 17.4 and 17.6%, values indicative of reaction with later, low-temperature water. Unaltered tridymite from higher in the stratigraphic section has a δ18O of 11.1% which, when coupled with the garnet δ18O values in a quartz-garnet fractionation equation, indicates isotopic equilibration (vapour-phase crystallization) at temperatures of ∼600°C. This high-temperature mineralization, formed during cooling of the tuffs, is distinct from the later and commonly recognized low-temperature stage (generally 50−70°C) of calcite, quartz and opal secondary mineralization, formed from downward-percolating meteoric water, that locally coats fracture footwalls and lithophysal floors.
34
Galuskina, Irina O., Evgeny V. Galuskin, Yevgeny Vapnik, Krystian Prusik, Marta Stasiak, Piotr Dzierżanowski, and Mikhail Murashko. "Gurimite, Ba3(VO4)2 and hexacelsian, BaAl2Si2O8 – two new minerals from schorlomite-rich paralava of the Hatrurim Complex, Negev Desert, Israel." Mineralogical Magazine 81, no. 4 (August 2017): 1009–19. http://dx.doi.org/10.1180/minmag.2016.080.147.
Full textAbstract:
AbstractTwo new barium-bearing minerals: gurimite, Ba3(VO4)2 (IMA2013-032) and hexacelsian, BaAl2Si2O8 (IMA2015-045) were discovered in veins of paralava cutting gehlenite-flamite hornfels located in the Gurim Anticline in the Negev Desert, Israel. Gurimite and hexacelsian occur in oval polymineralic inclusions in paralava and are associated with gehlenite, pseudowollastonite or wollastonite, rankinite, flamite, larnite, schorlomite, andradite, fluorapatite, fluorellestadite, kalsilite, cuspidine, aradite, zadovite and khesinite. Gurimite and hexacelsian form elongate crystals <10 μm thick. The minerals are colourless and transparent with a white streak and vitreous lustre, and have (0001) cleavage, respectively good in gurimite and very good in hexacelsian. Fracture is irregular. Density calculated using empirical formulas gave 5.044 g cm–3 for gurimite and 3.305 g cm–3 for hexacelsian. Mean refractive indexes, 1.945 and 1.561, respectively, were also calculated using the empirical formulas and the Gladstone-Dale relationship. The minerals are uniaxial and nonpleochroic. The following empirical crystal chemical formulae were assigned to holotype gurimite: (Ba2.794K0.092Ca0.084Na0.033Sr0.017)∑3.020(V1.8275+S0.0916+P0.0515+Al0.040Si0.005Fe0.0053+)∑2.017O8,and holotype hexacelsian: (Ba0.911K0.059Ca0.042Na0.010)∑1.022Al1.891Fe0.0723+Si2.034O8. The Raman spectrum of hexacelsian is similar to the one of the synthetic disordered β-BaAl2Si2O8. The Raman spectrum of gurimite is identical to that of synthetic Ba3(VO4)2. The electron back-scattered diffraction (EBSD) pattern of gurimite was fitted to the structure of its synthetic analogue with the cell parameters of R3m, a = 5.784(1),c = 21.132(1) Å, V = 612.2(2) Å3, Z = 3, giving a mean angular deviation = 0.43° (good fit). The Raman spectra of hexacelsian and its EBSD pattern suggest that natural hexacelsian corresponds to disordered synthetic β-hexacelsian P63/mcm, a = 5.2920(4) Å, c = 15.557(2) Å, α = β = 90°, γ = 120°. We suggest that after relatively fast crystallization of the main constituents of the paralava, gurimite, hexacelsian and also other Ba-bearing phases crystallized from residual melt enriched in incompatible elements that filled interstices between crystals of the main constituents.
35
Singh, Anjali, Rajendra Prakash Maurya, Virendra Pratap Singh, Swati Gautam, Anil Kumar, C. P. Mishra, P. Jain, et al. "Study of epidemiology, clinical profile, visual outcome and prognostic factors of blunt ocular trauma in a teaching hospital." Indian Journal of Clinical and Experimental Ophthalmology 8, no. 4 (December 15, 2022): 458–67. http://dx.doi.org/10.18231/j.ijceo.2022.094.
Full textAbstract:
To describe the epidemiology, patterns of ocular trauma, clinical presentation, visual outcome and prognostic factors of blunt ocular trauma.A teaching hospital based prospective observational study was conducted over a period of 4 years from March 2012 to Feb 2016. 226 patients of all age group fulfilling the various inclusion and exclusion criteria were included in the study. All patients underwent detailed protocol based workup including a comprehensive ocular examination along with relevant radiological tests. Data regarding demographic profile, etiology, circumstances of the injury, traumatic agents, mode and mechanism of injury, extent and severity of injury, clinical features, management and visual outcome was analyzed and prognostic factors including ocular trauma score were evaluated.Out of 402 total cases of ocular trauma, 226 caused by blunt objects were included in this study. 181 (80.1%) were male rest 45(19.9%) were female. The mean age was 42.6 ± 18.8 years. Blunt trauma was more prevalent in age group 16-25yrs (24.3%) followed by 26-35 years (23.9%). Majority (68.6%) of victims belonged to rural background. Most of the patients sustained trauma at road /street (30.5%) and home (27.9%). The most common cause of blunt trauma was road traffic accident (26.5%) followed by sports related injury (22.6%) and physical assault (21.7%). The most frequent traumatic agent was wooden object (26.0%) followed by stone / brick (25.2%) and metallic object (23.1%). Only 32.3% of patients had isolated ocular injuries, rest had associated polytrauma. 93.3% victims had unilateral ocular injury. Left eye (52.3%) was predominantly involved. Majority of injured eyes had more than 3 ocular structure involvement. Out of 241 injured eye 14.0% eyes had only globe injury while 61.4% eyes had simultaneous globe and adnexal injuries. 55.6% eyes had closed globe injury while 19.9% eyes had globe rupture. 20.7% eyes had purely posterior segment injury, while 23.2% eyes had both anterior and posterior segment injury. Most common clinical finding was corneal abrasion (45.6% eyes) followed by hyphema (44.0% eyes), traumatic mydriasis (35.7%), vitreous hemorrhage (33.2%) retinal detachment (20.3%), lens dislocation (22.8%) and traumatic cataract (17.4%). At the time of initial presentation 33.2% eyes had visual impairment and 35.7% eyes had blindness. 14.5% eyes with closed globe injury and 5.0% eyes with open globe injury had zone III injury. Ocular trauma score was in Category I in 14.9% injured eyes and in category II in 7.1% eyes. After 6 months 14.5% of the right eye and 24.2% of the left eye showed blinding outcome.Blunt trauma is the commonest mode of ocular injury. Young adult males are more vulnerable. Intraocular hemorrhage, zone III injury, posterior segment involvement and low ocular trauma score are poor prognostic factors.
36
Pautov, Leonid A., Mirak A. Mirakov, Fernando Cámara, Elena Sokolova, Frank C. Hawthorne, Manuchekhr A. Schodibekov, and Vladimir Yu Karpenko. "Badakhshanite-(Y), Y2Mn4Al(Si2B7BeO24), a new mineral species of the perettiite group from a granite miarolic pegmatite in Eastern Pamir, the Gorno Badakhshan Autonomous Oblast, Tajikistan." Canadian Mineralogist 58, no. 3 (May 1, 2020): 381–94. http://dx.doi.org/10.3749/canmin.2000003.
Full textAbstract:
ABSTRACT Badakhshanite-(Y), ideally Y2Mn4Al(Si2B7BeO24), is a tetrahedral sheet-structure mineral found in the Dorozhny (Road) miarolitic granitic pegmatite within the Kukurt pegmatite field 45 km E of Murghab, Eastern Pamir, Gorno-Badakhshan Autonomous Oblast, Tajikistan. Badakhshanite-(Y) occurs in medium- to coarse-grained non-graphic albite-microcline-quartz pegmatites in close association with smoky quartz, Sc-bearing spessartine, Sc-bearing tusionite, and schorl. It often grows together with Sc-bearing tusionite and occurs as single columnar crystals ranging from 50 to 400 μm in length, as inclusions in spessartine and tourmaline, and rarely as crystals in blebs along boundaries between garnet, tourmaline, and quartz. Badakhshanite-(Y) is yellow brown and has a white streak and a vitreous luster. It is brittle, with a conchoidal fracture, Mohs hardness of 6.5–7, and calculated density of 4.41 g/cm. In thin section it is transparent and pale yellow, non-pleochroic, biaxial (–), with α = 1.805(2), βcalc = 1.827, γ = 1.835(3) (λ = 590 nm); 2V (meas.) = –60(10)°. Dispersion is weak, r > v. Extinction is straight, elongation is negative. FTIR spectra show the absence of (OH) and H2O groups. Chemical analysis by electron microprobe using WDS (6 points), SIMS, and ICP-OES for B and Be gave SiO2 11.96, ThO2 0.12, Sm2O3 0.17, Gd2O3 0.30, Tb2O3 0.10, Dy2O3 0.73, Ho2O3 0.19, Er2O3 1.34, Tm2O3 0.54, Yb2O3 8.82, Lu2O3 2.32, Y2O3 16.60, Sc2O3 1.57, Al2O3 3.06, B2O3 22.06, FeO 0.94, MnO 23.33, CaO 0.58, BeO 2.84, total 97.57 wt.%.The empirical formula based on 24 O apfu is (Y1.21REE0.78Th0.01)Σ2(Mn3.47Y0.34Ca0.11Fe2+0.08)Σ4(Al0.63Sc0.24Fe2+0.06□0.07)Σ1[(Si2.10B6.69Be1.20)Σ9.99O24], where REE = (Yb0.47Lu0.12Dy0.04Er0.07Tm0.03 Ho0.01Gd0.02Sm0.01Tb0.01)Σ0.78. Badakhshanite-(Y) is orthorhombic, space group Pnma, a 12.852(1), b 4.5848(5), c 12.8539(8) Å, V 757.38(7) Å3, Z = 2. The crystal structure was refined to R1 = 4.31% based on 1431 unique [F > 4σF] reflections. In the crystal structure of badakhshanite-(Y), a layer of tetrahedra parallel to (010) is composed of four different tetrahedrally coordinated sites: Si, B(1), B(2), and T (<Si–O> = 1.623 Å, <B(1)–O> = 1.485 Å, <B(2)–O> = 1.479 Å, <T–O> = 1.557 Å), which form four-, five-, and eight-membered rings, having the composition (Si2B7BeO24). Between the sheets of tetrahedra, there are three cation sites: M(1), M(2), and M(3) (<M(1)–O> = 2.346 Å, <M(2)–O> = 2.356 Å, <M(3)–O> = 2.016 Å) occupied by Y(REE), Mn2+(Y, Ca, Fe2+), and Al(Sc), respectively. The M(1,2) sites ideally give Y2Mn4apfu; the M(3) site ideally gives Al apfu. Badakhshanite-(Y) is an Al- and Be-analogue of perettiite-(Y).
37
Jabr, Monawar Muhsin, Hussain S. Hasan, and Hind Ahmed Mahdi. "Visual Acuity, Intraocular Pressure, and Macular Thickness in Patients Undergoing Dialysis." NeuroQuantology 19, no. 6 (July 14, 2021): 98–106. http://dx.doi.org/10.14704/nq.2021.19.6.nq21074.
Full textAbstract:
Background: Chronic kidney disease (CKD) is a public health problem over all the world. CKD may also be defined by the presence of kidney damage or a reduced glomerular filtration rate (GFR), which is the best overall indicator or index of kidney function. CKD patients are usually treated using kidney dialysis (hemodialysis) that uses a blood filtration mechanism (HD). Several metabolic parameters, such as blood urea, sodium, potassium, and glucose levels, can alter during HD. Osmotic alterations in blood, aqueous and vitreous humor, and other extracellular fluids arise from these fluctuations. That also can affect visual acuity, intraocular pressure (IOP), and retinal thickness. Aim of the Study: To evaluate some of the ocular findings undergoing HD to keep prevent the loss of patient vision such as visual acuity (VA), intraocular pressure (IOP), central corneal thickness (CCT), central Foveal Thickness (CFT), retinal nerve fiber layer (RNFL). Patient& Methods: This is a cohort (prospective) design study. This study including Seventy nine patients divided into two groups the first group from one week to six month (9 femal & 18 males) another group over than six month (36 female & 16 male) the average age between (12 to 70 years). This research performed in the three places department of the eye in Al-Hussein hospital in Samawah city, Al-Haboby hospital, Al-Hussein hospital in Dhi Qar city finally in Al-Shaheed Gazy hospital and Baghdad teaching hospital in Baghdad. Examining Visual Acuity by Snellen chart & auto refractometer, IOP& CCT by (CT.1 Computerized Tonometer TOPCON), RNLF and Central Foveal Thickness by OCT (Carl ZEISS, TOPCON). The inclusion criteria were as follows: all the patients undergoing dialysis from one week to over six months. Exclusion criteria were as follows: the patients have diabetic, any patients have a hereditary disease or glaucoma history or laser therapy, or intraocular injection in the eye before dialysis, the patients have a problem in the eye before dialysis such as cataracts or opacity leads to does surgery, the patients who have a refractive error or wear glass had been also excluded. Result: Includes the results of seventy-nine patients (45 females and 34 males) with chronic kidney disease examined ocular findings before a session of dialysis divided into two groups based on their duration of dialysis. Group one with twenty-seven patients (9 female & 18 male) under dialysis from one week to six months with mean & standard deviation (3.2037, ± 1.89259), group tow with fifty tow patients (36 female & 16 male) under dialysis from the duration over than six months with mean & standard deviation (44.2308, ± 26.24367) respectively. Patients aged (12 to 70 years) had mean age & ± standard deviation (35.1481, ± 12.88918), (44.4038, ± 15.42249) for two groups respectively. Patients in two groups had IOP (Right eye), its mean & standard deviation (15, ± 2.34), (15.69, ± 2.56) for group one & group tow respectively. Also, patients had CCT (Right eye) with mean & standard deviation (5.3467E2, ± 39.00296), (5.2312E2, ± 30.44162) for group one & group tow respectively. Patients had CCT (Left) with mean & standard deviation (5.2878E2, ± 37.55748), (5.2179E2, ± 29.58957) for group one & group tow respectively. Patients in two groups had average thickness RNFL (Right eye) with mean & standard deviation (1.0604E2, ± 25.17551), (95.6154, ± 21.27150) for group one & group tow respectively. Also, patients had average thickness RNFL (left eye) with mean & standard deviation (1.0930E2, ±23.80177), (98.7500, ± 23.77334) for group one & group tow respectively. Conclusions: This study found CCT effective with dialysis tend to be thin (53 patient,18 patient in group one &35 in group two) and that will be had a threefold higher risk of developing glaucoma when compared with thick average because of the IOP value affected by it. Refractive error effective with dialysis & become was more prominent that can be shown in the group two have (40 patient from 52) while (15 patient from27) in the group one although a lot of them corrected to the BCVA. In conclusion high value of the C/D ratio formed about (45.57%, 53.16%) to the right &left eye respectively this value will be form important sign of risk factor to progressive of glaucomatous need to be alert in the future. Also our research reveals CFT effective undergoing dialysis the thick value was (56 in the right eye, 55 in the left eye) high compared with the thin (9 in the right&9 in the left eye) & normal (14 in the right eye, 15 in the left eye). All the two groups of patients will be effected by the duration of dialysis with a time.
38
Yousef, Mohamed, Safaa Bashir, Awadalla Wagealla, Mogahid Zidan, Mahmoud Salih Babiker, and Mona Mohamed. "Prevalence of Vitreous & Retinal Disorders among Sudanese Diabetic Patients: A B-Scan Ultrasonography Study." Pertanika Journal of Science and Technology 29, no. 2 (April 30, 2021). http://dx.doi.org/10.47836/pjst.29.2.33.
Full textAbstract:
Retina and vitreous abnormalities represent the most common eye disorders in diabetic patients; they may be associated with severe complications. Therefore, this study aimed to study the prevalence of vitreous and retinal pathologies in diabetic patients using B-Scan ultrasound (U/S). A total of two hundred and three Sudanese diabetic patients with long diabetic disease duration (mean 16.28 ± 4.830) years were enrolled in a descriptive-analytical study. 55% (n = 112) were males and 45% (n = 91) were females. The mean age of the participants was 62.28 ± 8.041(range between 30-79 years -old). The study was conducted in a Sudanese ophthalmologic hospital in Khartoum, during the period from 2016–2019. A Nidek (Echoscan US–4000) - B-scan ultrasound unit with 10 MHZ transducer was used. A high-frequency direct contact technique was applied. The inclusion criteria included adult diabetic patients. The vitreous and retina disorders were more prevalent in diabetic hypertensive participants 55 % (n = 112). The high frequency of the disorders was observed in age groups: 60–69 and 50–59 years-old. The most common disorder was retinal detachment which was detected in30.5% (n = 62) followed by vitreous changes in16.3% (n = 33). Posterior vitreous was observed in 15.8% (n = 32), vitreous hemorrhage seen in 15.3% (n = 31), both retinal detachment with vitreous hemorrhage were detected in 11.3%) (n = 23), retinal detachment with cataract were reported in 3.4% (n = 7), retinal detachment with Vitreous changes were seen in 3% (n = 6), and other changes were noted in 4.4% (n = 9) of the participants. There is no significant a statistical association between gender/diabetic duration and age with the disorders (P = 0.2, 0.43, and 0.5) respectively. Vitreous & Retinal disorders were more prevalent in diabetic hypertensive patients. The high frequency of the disorders was observed in the age group (50–70). The ultrasound is a useful method in diagnosing Vitreous & Retinal disorders among the diabetics.
39
Beitz, James V., S. Skanthakumar, S. Seifert, and P. Thiyagarajan. "f-Element Influence on the Size of Nanophase Phosphate Inclusions in Silica." MRS Proceedings 802 (2003). http://dx.doi.org/10.1557/proc-802-dd3.9.
Full textAbstract:
ABSTRACTInsight into the factors that control the formation and size of heavy metal phosphate nanophases in vitreous silica has been gained by combining conventional and anomalous small angle x-ray scattering studies with powder x-ray diffraction and laser-induced fluorescence investigations. Europium, thorium, and uranyl ions were sorbed from aqueous solutions into a chemically functionalized porous silica (termed Diphosil). Aliquots of those samples were heated to a series of temperatures that spanned the pore collapse point. Loading with trivalent europium ions resulted in production of nanophases whose size corresponded to the average number of metal ions per pore. Thorium or uranyl ions resulted in retention of porosity to higher temperature with eventual pore collapse that evidently resulted in formation of nanophases whose size exceeded that determinable under the experimental conditions.
40
Abouodah, Hythem, Karam Hamada, Matthew Pfannenstiel, and Radwan Ajlan. "Endoscopic Pars Plana Vitrectomy in Patients With Open-Globe Injury and Corneal Opacity." Journal of VitreoRetinal Diseases, February 19, 2023, 247412642311513. http://dx.doi.org/10.1177/24741264231151370.
Full textAbstract:
Purpose: To determine the 1-year outcomes of endoscopic pars plana vitrectomy (EPPV) and its impact on the corneal transplantation rate in patients with open-globe injury (OGI) and corneal opacity. Methods: This retrospective cohort study collected data between December 2018 and August 2021. All EPPVs were performed at a level I trauma center. Inclusion criteria were adult patients with a history of OGI complicated by corneal opacification that prevented fundus visualization. The main outcome measures were the rate of successful retinal reattachment, final visual acuity (VA), and number of patients who had penetrating keratoplasty (PKP) within 1 year of the OGI. Results: Ten patients (3 women; 7 men) with a mean age of 63.4 ± 22.7 years (SD) met the inclusion criteria. The indications for EPPV were intraocular foreign bodies in 2 patients, dense vitreous hemorrhage in 3 patients (1 with a retinal tear; 1 with a choroidal hemorrhage), and retinal detachment in 5 patients. The final VA ranged from 20/40 to no light perception. All 4 repaired detachments remained attached after 1 year. Corneal opacity was treated with PKP in 3 patients. Conclusions: Results indicate EPPV can be a useful tool to treat posterior segment pathology in patients with a recent OGI and corneal opacity. EPPV can help address posterior segment disease and postpone corneal transplantation until the visual potential can be fully determined. Larger prospective studies are needed.
41
Saeed, Nasir, Tariq Farooq Babar, Sanaullah Jan, Ibrar Hussain, and Mohammad Daud Khan. "Titrated Cyclocryopexy - A report on long term results." Annals of King Edward Medical University 11, no. 4 (April 30, 2016). http://dx.doi.org/10.21649/akemu.v11i4.1099.
Full textAbstract:
Objective: To determine the efficacy and safety of a titrated cyclocryopexy in advanced glaucomatous eyes in term of intraocular pressure control and complications. Material and Methods: Retrospective Cohort analysis of a titrated cyclocryopexy in 30 eyes of 25 patients with uncontrolled glaucoma during July 1996 to July 2003 at Hayatabad Medical Complex, Peshawar. Inclusion criteria applied was; patients having uncontrolled IOP with maximum medical therapy, previous trabeculectomy and a minimum follow-up of 2 years. All patients were assessed for glaucoma. Numbers of cryoapplications were determined according to the IOP. Four to 12 applications in one sitting were used. Repeat cryoapplication were applied at least after six-weeks of previous therapy if IOP was not controlled. Results: A total of 30 eyes of 25 patients were studied. IOP control of less than 21 mm Hg was achieved in 83% of the eyes. Mean IOP was reduced from 29 ± 4.96 pre-op to 17 ± 7.36 at two years follow-up. Forty percent of the eyes ne eded single session, 40% received 2 sessions and other 20% needed sessions. All the patients lost at least one line of Snellen chart at 2 years follow-up, 70% retained useful vision, 20% retained light perception and 10% lost perception of light. Serious complications included phthisis, persistent vitreous hemorrhage with retinal detachment, and total retinal detachment and persistent vitreous hemorrhage in 1 eye each. Conclusion: Cyclocryopexy appears to be an effective procedure in cases of advanced glaucoma with an acceptable risk / benefit ratio. If done in a titrated manner the number of complications are reduced in severity.
42
Dervenis, Nikolaos, Anna Praidou, Panagiotis Dervenis, Dimitrios Chiras, and Brian Little. "Visual Acuity Outcomes after Phacoemulsification in Eyes with Good Visual Acuity before Cataract Surgery." Medical Principles and Practice, January 25, 2021. http://dx.doi.org/10.1159/000514662.
Full textAbstract:
Abstract Objective: To analyze cataract surgery outcomes and related factors in eyes presenting with good visual acuity. Subject and Methods: Retrospective longitudinal of patients undergoing phacoemulsification between the years 2014-2018 in Moorfields Eye Hospital and satellite units. Pre- and postoperative visual acuity (unaided, with glasses, with pinhole) were analyzed. Inclusion criteria were age≥40 years and pinhole visual acuity ≥6/9 preoperatively. Exclusion criteria were no postoperative visual acuity data. VA change variable was also defined according to postoperative visual acuity being above or below the Snellen 6/9 threshold. Results: 2720 eyes were included in the analysis. The unaided LogMAR visual acuity improved from 0.54 to 0.20 (p<0.001), the LogMAR visual acuity with glasses improved from 0.35 to 0.05(p<0.001) and the LogMAR pinhole visual acuity improved from 0.17 to 0.13(p<0.001). 8.1% of patients had Snellen visual acuity <6/9 postoperatively. Mean follow up period was 23,6±9.9 days. In multivariate logistic regression, factors associated with visual acuity <6/9 postoperatively were: age [OR=0.96, 95% CI (0.95, 0.98), p<0.001], vitreous loss [OR=0.21, 95% CI (0.08, 0.56), p=0.002] and iris trauma [OR=0.28, 95% CI (0.10, 0.82) p=0.02]. No significant adverse events occurred. Conclusions: Visual acuity improved significantly overall in this group of patients, although at least 8.1% of them did not reach their pinhole preoperative visual acuity. Worse visual acuity outcomes were associated with increasing age, vitreous loss and iris trauma. The 6/9 vision threshold may not be able to accurately differentiate those who may benefit from cataract surgery and those who may not.
43
Marshall, Alan T., and Sheila G. Crewther. "Osmotic gradients and transretinal water flow—a quantitative elemental microanalytical study of frozen hydrated chick eyes." Frontiers in Cellular Neuroscience 16 (October 24, 2022). http://dx.doi.org/10.3389/fncel.2022.975313.
Full textAbstract:
Optical clarity and efficient phototransduction are necessary for optimal vision, however, how the associated processes of osmoregulation and continuous fluid drainage across the whole eye are achieved remains relatively unexplored. Hence, we have employed elemental microanalysis of planed surfaces of light-adapted bulk frozen-hydrated chick eyes to determine the unique intracellular elemental localization, compositions, and hydration states that contribute to maintaining osmotic gradients and water flow from the vitreous, across the retina, retinal pigment epithelium (RPE), to choroid and sclera. As expected, the greatest difference in resultant osmotic concentration gradients, [calculated using the combined concentrations of sodium (Na) and potassium (K)] and tissue hydration [oxygen-defined water concentration], occurs in the outer retina and, in particular, in the RPE where the apical and basal membranes are characterized by numerous bioenergetically active, osmoregulating ion transport mechanisms, aquaporins, and chloride (Cl) channels. Our results also demonstrate that the high intracellular Na+ and K+ concentrations in the apical region of the RPE are partially derived from the melanosomes. The inclusion of the ubiquitous osmolyte taurine to the calculation of the osmotic gradients suggests a more gradual increase in the osmotic transport of water from the vitreous into the ganglion cell layer across the inner retina to the outer segments of the photoreceptor/apical RPE region where the water gradient increases rapidly towards the basal membrane. Thus transretinal water is likely to cross the apical membrane from the retina into the RPE cells down the Na+ and K+ derived osmotic concentration gradient and leave the RPE for the choroid across the basal membrane down the Cl− derived osmotic concentration gradient that is sustained by the well-described bioenergetically active RPE ion transporters and channels.
44
Bingham, Paul A., Russell J. Hand, and Charlie R. Scales. "Immobilisation of Simulated Plutonium-Contaminated Material in Phosphate Glass: An Initial Scoping Study." MRS Proceedings 932 (2006). http://dx.doi.org/10.1557/proc-932-89.1.
Full textAbstract:
ABSTRACTVitrification is a potential route for the immobilisation of Plutonium Contaminated Material (PCM). This is an Intermediate Level Waste (ILW) arising from operations in which there is contact with Pu isotopes. PCM consists of low levels of Pu combined with metals, masonry, glass, ceramics, polymers and other carbonaceous materials. Simulated PCM containing CeO2 as a PuO2 surrogate was mixed with a phosphate precursor and vitrified. Pre-oxidation of PCM simulant prior to vitrification minimised the violence of batch reactions. No pre-oxidation produced inhomogeneous slag-like materials with high residual metals and particulates. Pre-oxidation at 600°C in air and at 1200°C in an O2-rich atmosphere produced more favourable results, with increasingly vitreous products resulting from more oxidised PCM simulant. The most oxidised PCM simulant produced phosphate glasses with low levels of particulate inclusions, as confirmed by x-ray diffraction and scanning electron microscopy. Particulates included iron-rich metallics and aluminous oxides. Increased melting times and temperatures may have reduced the number of inclusions slightly, but O2 bubbling during melting resulted in little additional benefit. Waste loading equivalent to ∼60 weight % of untreated waste may be possible. There was little evidence of Ce partitioning, indicating that it was immobilised within the glass matrix and had little preference for metallic or crystalline phases. These results demonstrate the potential feasibility for vitrification of PCM in phosphate glass, justifying further investigation into this potentially novel solution.
45
Liu, Yao, Neda Baniasadi, Kitiya Ratanawongphaibul, and Teresa C. Chen. "Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements." British Journal of Ophthalmology, February 12, 2020, bjophthalmol—2019–314570. http://dx.doi.org/10.1136/bjophthalmol-2019-314570.
Full textAbstract:
Background/aimsTo assess the effect of partial posterior vitreous detachment (pPVD) on spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fibre layer thickness (RNFL) measurements.MethodsSpectral-domain OCT RNFL thickness measurements were obtained from 684 consecutive patients who were seen in the Massachusetts Eye and Ear Glaucoma Service. Of these patients, we compared RNFL thickness measurements between 101 eyes of 101 glaucoma suspects who met inclusion criteria (55 eyes with and 46 eyes without pPVD).ResultsAmong all 684 patients, 253 (37%) had pPVD in at least one eye. Among a subset of 101 eyes of 101 glaucoma suspects, average RNFL thickness was greater in eyes with compared to eyes without pPVD (p=0.02). Measurements were significantly greater in the inferior (p=0.004) and superior quadrants (p=0.008), but not in the nasal (p=0.10) and temporal quadrants (p=0.25). The difference in average RNFL thickness remained significant (p=0.05) even when corrected for expected age-related decline in RNFL thickness.ConclusionOver a third of patients were found on peripapillary spectral-domain OCT to have a pPVD, which was associated with greater RNFL thickness measurements. Judicious clinical interpretation of this finding on spectral-domain OCT RNFL thickness scans should be factored into the assessment of glaucoma suspects.
46
Tasiopoulou, Anastasia, Cristhian A. Urzua, and Susan Lightman. "Successful treatment of cytomegalovirus retinitis with oral/intravitreal antivirals in HIV-negative patients with lymphoma." Eye, October 3, 2022. http://dx.doi.org/10.1038/s41433-022-02267-0.
Full textAbstract:
Abstract Objectives To report patients with systemic lymphoma and cytomegalovirus (CMV) retinitis, treated with a combination of oral and intravitreal antiviral agents on an outpatient basis. Methods Retrospective cases series. Information was gathered from the database of the Uveitis clinics at Moorfields Eye Hospital, United Kingdom from December 2014 to December 2018. The inclusion criteria comprised the diagnosis of systemic lymphoma, associated with a diagnosis of CMV retinitis. Exclusion criteria were alternative ocular diagnosis, human immunodeficiency virus (HIV), primary intraocular lymphoma, or other causes of immunosuppression. Results All seven subjects had been under oncologist care for systemic lymphoma. CMV retinitis presented with a median of 61 months after the systemic lymphoma diagnosis. Five patients underwent a vitreous biopsy, and four of them returned PCR positive for CMV and the fifth patient had PCR positive in a blood sample. All patients were treated with oral Valganciclovir, with an induction dose of 900 mg every 12 h for up to 3 weeks until disease resolution and a maintenance dose thereafter. All but one received additional intravitreal Foscarnet injections, with a dose of 2.4 mg /0.1 ml. Conclusions The management of patients with systemic lymphoma and CMV retinitis with oral and intravitreal antiviral agents, resulted in effective disease control.
47
Pfister, Tyler, Carisa Bohnak, and Shriji Patel. "Wood-Related Open-Globe Injuries." Journal of VitreoRetinal Diseases, September 1, 2020, 247412642094662. http://dx.doi.org/10.1177/2474126420946624.
Full textAbstract:
Purpose: This work evaluates the clinical characteristics, visual outcomes, and complications of patients treated for open-globe injuries (OGIs) caused by wooden objects. Methods: A retrospective review of medical records was conducted on patients presenting to a tertiary trauma center with an OGI between January 2005 and December 2017. Medical records were isolated for wounds caused by wooden objects. Patient demographics were recorded, with presenting visual acuity (VA), physical examination findings, and wound characteristics. After primary globe repair, secondary complications, need for additional surgery, and visual outcomes were noted until final examination. Main outcome measures were final VA and secondary complications. The Ocular Trauma Score (OTS) was computed and assessed for clinical relevance related to visual outcomes. Results: Thirty-two patients met the inclusion criteria, with 15 (47%) being injured by plant material. Thirty of the patients were men (94%). A large portion of patients presented with hand motion or worse vision (48%), and there were high rates of hyphema (59%), vitreous hemorrhage (31%), retinal detachment (28%), and endophthalmitis (9%). Two patients eventually required enucleation. At last follow-up, 19 patients achieved 20/100 VA or better (59.4%), which correlated with their OTS ( P < .001). Conclusions: Despite the high clinical severity of wood OGIs, the potential for visual recovery remains high. The OTS appropriately assesses the severity of injuries and the likely prognosis in this cohort of patients.
48
Fallon, Julia, Swati Narayan, Jun Lin, Jodi Sassoon, and Stephanie Llop. "The impact of polymerase chain reaction (PCR) on diagnosis and management of infectious uveitis at a tertiary care facility." Journal of Ophthalmic Inflammation and Infection 12, no. 1 (January 6, 2022). http://dx.doi.org/10.1186/s12348-021-00276-w.
Full textAbstract:
Abstract Background Polymerase Chain Reaction (PCR) is a well-accepted adjunct in the management of infectious uveitis. In turn, few reports in the literature have evaluated how PCR then impacts patient care. This study aims to evaluate the impact of PCR sampling on diagnosis and treatment of infectious uveitidies at a large tertiary care facility. Main body This is a retrospective, observational study of patients with aqueous and vitreous PCR samples obtained from 2014 to 2019. The study was undertaken at a single institution. At least one follow up visit following results of PCR testing was required for inclusion. If a patient had multiple PCR samples taken, only the first sample was included. The patients were divided into three categories based on pre-sampling diagnosis. A chi-square test was used to analyze the data. 108 cases were available for analysis. PCR did not change diagnosis or management in any of the cases where pre-sampling diagnosis carried a high clinical suspicion for negative PCR. Overall, the results of PCR testing had a more significant impact on diagnosis in those cases where pre-sampling diagnosis was unknown versus those where it was confirmatory in nature, thus presumed to be related to an infectious entity tested by PCR (74% vs. 29%, p = 0.00006). The rate of treatment change based on PCR was similar between those cases where there was a high clinical suspicion for positive PCR and those where pre-sampling diagnosis was unknown (32% vs. 33%, p = 0.95). Further analyzing specimens separately depending on source of sample, this pattern persisted for aqueous samples, with PCR showing a more significant impact on diagnosis in those cases where the diagnosis was unknown versus those where sampling was confirmatory (86% vs. 31%, p = 0.00004). The rate of change in treatment between the two groups was similar (35% vs. 31%, p = 0.79). Vitreous samples followed a similar pattern with a higher rate of diagnosis change for those cases where pre-sampling diagnosis was unknown and a similar rate in treatment change between the two groups, however this did not reach statistical signifigance (44% vs. 25%, p = 0.28; 27% vs. 33%, p = 0.74). Conclusion There is no well-defined algorithm as to when to employ PCR testing in uveitis. As expected, in our experience, it has the largest impact on diagnosis when the diagnosis is unknown, however even when confirmatory in nature, it continues to impact patient management.
49
Ebrahimiadib, Nazanin, Zahra Kianzad, Mohammad Zarei, Samaneh Davoudi, Hamid Riazi-Esfahani, Fatemeh Bazvand, Zahra Mahdizad, and Bobeck S. Modjtahedi. "Non-cystic macular thickening on optical coherence tomography as an alternative to fluorescein angiography for predicting retinal vascular leakage in early stages of uveitis." Scientific Reports 12, no. 1 (August 5, 2022). http://dx.doi.org/10.1038/s41598-022-17701-2.
Full textAbstract:
AbstractTo evaluate the relationship between non-cystic thickening of the macula on optical coherence tomography (OCT) and retinal vascular leakage on fluorescein angiogram (FA) in patients with uveitis. A cross-sectional study of patients seen in the uveitis clinic. Patients with any degree of inflammatory cells in the anterior vitreous were included, provided that no macular cyst or subretinal fluid or macular atrophy was observed in OCT. The correlation between OCT features and best corrected visual acuity (BCVA), the degree of inflammation, and FA findings were examined. The severity of vascular leakage in FA was graded for optic nerve, macula and posterior and peripheral leakage. We used generalized estimation equation to assess the associations between macular thickness and volume with angiographic scores. A total of 43 patients (100 exam data) met inclusion criteria. There was a significant relationship between OCT parameters (central macular thickness, 3 mm and 6 mm perifoveal macular thickness as well as total and central macular volume) with angiographic scores (macular, optic disc, posterior and peripheral vascular leakage score) (all P values < 0.0001). The correlation between the 6 mm perifoveal thickness and peripheral vascular leakage score (R = 0.76; P < 0.001) was stronger than the correlation of CMT with this angiographic score (R = 0.69; P < 0.001). Non-cystic thickening of the macula on OCT, especially in perifoveal area, is a reliable predictor of the presence of retinal vascular leakage in patients with uveitis.
50
Fang, Dong, Jindi Su, Lu Chen, and Shaochong Zhang. "The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy." Frontiers in Medicine 8 (January 7, 2022). http://dx.doi.org/10.3389/fmed.2021.802626.
Full textAbstract:
Purpose: To describe the longitudinal structural changes of myopic traction maculopathy (MTM) based on optical coherence tomography (OCT) and to detect biomarkers in the evolution of MTM.Methods: A retrospective study was conducted on patients with MTM as defined by OCT. A minimum follow-up of 6 months was necessary for study inclusion. The effects of comprehensive OCT-based structure on the evolution of MTM, the progression rates, and resolution rates of MTM were evaluated.Results: A total of 120 eyes (120 patients) were included with an average follow-up of 15.4 months. During the follow-up, MTM progressed in 32 eyes (26.67%). The most common pattern of progression observed was the increased extent of retinoschisis in 12 eyes. The multivariate analysis showed that the presence of MTM progression had a significant correlation with internal limiting membrane (ILM) detachment and retinoschisis involved the entire macula at baseline. Five eyes (4.17%) experienced MTM resolution, of which 2 eyes developed disruptions of detached ILM, two eyes developed disruptions of epiretinal membrane, and one eye developed partial posterior vitreous detachment. Eyes with foveal detachment showed the highest progression rate (41.67%) and highest resolution rate (16.67%) compared to the eyes with other foveal complications.Conclusion: ILM detachment is a risk factor for MTM progression and MTM resolution can occur after ILM disruption. These suggest that ILM may play an important role as a biomarker in the evolution of MTM.