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Journal articles on the topic 'In weanling rat'

Author: Grafiati

Published: 2 July 2022

Last updated: 31 July 2025

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1

Takahashi, M., H. Homma, and M. Matsui. "Developmental changes in the isoelectric variants of rat hepatic hydroxysteroid sulphotransferase." Biochemical Journal 293, no. 3 (1993): 795–800. http://dx.doi.org/10.1042/bj2930795.

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Major isoenzymes of androsterone-sulphating sulphotransferase (AD-ST) were isolated from liver cytosols of weanling and young adult female rats and their isoelectric properties were compared. On chromatofocusing the enzyme activity of young adults was eluted over a wider range of pH than was that of weanling rats. The activity at pH 7.8-7.2 (fraction I) is obvious at both ages, whereas the activity eluted over the pH 6.6-5.5 range (fraction II) is much lower in weanlings than in young adults. The AD-ST activities eluted in fractions I and II were separately purified by 3′-phosphoadenosine 5′-p

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2

Bedrick, Alan D., Susanne M. Johnson та Otakar Koldovsky. "In Vitro Intestinal Processing of Prostaglandin F_2α in Rats". Journal of Pediatric Gastroenterology and Nutrition 7, № 5 (1988): 755–61. http://dx.doi.org/10.1002/j.1536-4801.1988.tb09629.x.

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SummaryCytoprotective prostaglandins (PGs) such as PGF2α are present in milk and can be absorbed intact from the gastrointestinal tract. Developmental differences in gastrointestinal PG metabolism in vivo have been previously reported. To evaluate the role of small intestinal tissue. detailed analysis of PG processing in vitro of small intestinal segments of suckling and weanling rats using everted sacs was performed. Sacs were incubated in Krebs‐Ringer bicarbonate buffer, pH 7.4, at 37°C. Bathing mucosal fluid contained [H]PGF2α. Proximal and middle intestinal segment everted sacs of suckling

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3

Dowell, Russell T. "Metabolic and cyclic nucleotide enzyme activities in muscle and nonmuscle cells of rat heart during perinatal development." Canadian Journal of Physiology and Pharmacology 63, no. 1 (1985): 78–81. http://dx.doi.org/10.1139/y85-014.

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Enzyme activities related to aerobic metabolism and cyclic nucleotides were evaluated in muscle and nonmuscle cells of rat heart. The perinatal period from weaning to adult was studied. Malate dehydrogenase, citrate synthase, and 3-hydroxyacyl-CoA dehydrogenase activities of nonmuscle cells equal or exceed muscle cell activities in the weanling heart. Aerobic enzymes remain unchanged in nonmuscle cells during growth; however, muscle cell activities are enhanced. Adenylate cyclase and guanylate cyclase activities are higher in heart homogenates of weanling than adult rats. Despite elevated aden

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4

Martin, A. F., D. C. Robinson, and R. T. Dowell. "Isomyosin and thyroid hormone levels in pressure-overloaded weanling and adult rat hearts." American Journal of Physiology-Heart and Circulatory Physiology 248, no. 3 (1985): H305—H310. http://dx.doi.org/10.1152/ajpheart.1985.248.3.h305.

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We examined the relationship between ventricular isomyosin composition and plasma thyroxine (T4) 5 wk after partial constriction of the abdominal aorta in weanling (21 day) and adult (8 wk) rats. Cardiac enlargement in weanling aorta-constricted animals was associated with a significant (P less than 0.001) decrease in %V1 isomyosin in both left (32%) and right ventricles (25%) with a corresponding increase in the %V3 isomyosin and a reduction in plasma T4 levels. However, the ratio of V1/T4 was similar in weanling control (17.8 +/- 0.8) and aorta-constricted (18.0 +/- 1.4) rats. In adult aorta

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5

Narkewicz, Michael R., Sherrie Caldwell, and Gayle Jones. "Cysteine Supplementation and Reduction of Total Parenteral Nutrition—Induced Hepatic Lipid Accumulation in the Weanling Rat." Journal of Pediatric Gastroenterology and Nutrition 21, no. 1 (1995): 18–24. http://dx.doi.org/10.1002/j.1536-4801.1995.tb11728.x.

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SummaryTotal parenteral nutrition (TPN)‐induced hepatic steatosis is the most common complication of TPN administration to humans. The mechanism of TPN‐induced hepatic steatosis has not been studied in young mammals. The goal of this study was to determine the mechanism of TPN‐induced hepatic steatosis in the weanling rat and the effect of supplementation of TPN with choline and/or cysteine on TPN‐induced hepatic steatosis. In the weanling rat, we investigated the effect of TPN administration on histologic hepatic steatosis, total hepatic lipid, hepatic acetyl‐CoA‐carboxylase (ACC—the rate lim

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6

WAMBERG, S., K. ENGEL, and P. KILDEBERG. "Methionine-induced acidosis in the weanling rat." Acta Physiologica Scandinavica 129, no. 4 (1987): 575–83. http://dx.doi.org/10.1111/j.1748-1716.1987.tb08099.x.

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7

Rao, R. K., O. Koldovsky, and T. P. Davis. "Inhibition of intestinal degradation of somatostatin by rat milk." American Journal of Physiology-Gastrointestinal and Liver Physiology 258, no. 3 (1990): G426—G431. http://dx.doi.org/10.1152/ajpgi.1990.258.3.g426.

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In vitro degradation of 125I-labeled somatostatin-14 (Tyr11) [I-SS-14(Tyr11)] by luminal flushings of rat gastrointestinal segments was studied to characterize the fate of somatostatin in the gastrointestinal lumen. In addition, we evaluated the effect of rat milk as a potential inhibitor of luminal degradation of 125I-SS-14(Tyr11). Degradation of 125I-SS-14(Tyr11) was not detected in stomach flushings from either suckling or weanling rats. Luminal flushings from the small intestine degraded 125I-SS-14(Tyr11), with a gradient increase of activity from duodenum to midjejunum (degradation in suc

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8

Britton, John R., and Otakar Koldovsk. "Effect of Short‐Term Food Deprivation on Luminal Protein Digestion in Suckling and Weanling Rats." Journal of Pediatric Gastroenterology and Nutrition 6, no. 5 (1987): 789–94. http://dx.doi.org/10.1002/j.1536-4801.1987.tb09400.x.

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SummaryAlthough previous studies have described the effects of long‐term undernutrition on the process of protein digestion, little data exist regarding the impact of short‐term food deprivation on digestive processes. To evaluate the effect of short‐term food deprivation on luminal proteolytic activity in the rat, we incubated [125I]bovine casein in vitro at 37°C with fluid flushed from the lumen of stomach and small intestine of 12‐day‐old suckling and 31‐day‐old weanling rats that were either fed or food deprived for 12 h/100 g body weight (3 h for sucklings, 12 h for weanlings), followed b

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9

Williamson, D. H., and V. Ilic. "Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development." Biochemical Journal 231, no. 3 (1985): 773–75. http://dx.doi.org/10.1042/bj2310773.

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The activities of two mitochondrial enzymes concerned in the utilization of acetoacetate, namely 3-oxoacid CoA-transferase and acetoacetyl-CoA thiolase, were high throughout the suckling and weanling period in brown adipose tissue of the rat. In contrast, 3-hydroxybutyrate dehydrogenase activity was comparatively low during this period. The activity of cytosolic acetoacetyl-CoA synthetase (involved in lipogenesis) declined after birth and remained low until the pups were weaned. Experiments with brown-adipose-tissue slices from weanling rats indicated that 70% of the [3-14C]acetoacetate utiliz

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10

Bernardis, L. L., J. Medige, R. Gillespie, H. Wu, and I. Ziv. "The Lateral Hypothalamic Syndrome in the Weanling Rat." Physiology & Behavior 67, no. 5 (1999): 799–802. http://dx.doi.org/10.1016/s0031-9384(99)00097-9.

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11

BLAKE, H., and S. HENNING. "Basis for lactose aversion in the weanling rat." Physiology & Behavior 35, no. 2 (1985): 313–16. http://dx.doi.org/10.1016/0031-9384(85)90355-5.

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12

Engelhardt, Elizabeth L., Josef Neu, Mira B. Sankar, Phyllis A. Gimotty, and Jay W. Meyer. "Changes in Phospholipid and Cholesterol Concentrations of the Rat Microvillus Membrane During Maturation." Journal of Pediatric Gastroenterology and Nutrition 9, no. 1 (1989): 89–93. http://dx.doi.org/10.1002/j.1536-4801.1989.tb09826.x.

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Summary:We studied the cholesterol and phospholipid content and the cholesterol‐to‐phospholipid molar ratio of the small intestinal microvillus membrane in fetal, weanling, and adult rats. We also investigated the effect of glucocorticoid administration on these lipids and the ontogeny of 1,2‐diglycerol‐CDP choline phosphocholine transferase (PCT). Cholesterol and phospholipid concentrations decreased with maturation, phospholipids declining more than cholesterol. Thus, the cholesterol‐to‐phospholipid molar ratio rose with maturation. A similar decline was seen with PCT activity. Glucocorticoi

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13

Said, H. M., F. K. Ghishan, and J. E. Murrell. "Ontogenesis of intestinal transport of 5-methyltetrahydrofolate in the rat." American Journal of Physiology-Gastrointestinal and Liver Physiology 249, no. 5 (1985): G567—G571. http://dx.doi.org/10.1152/ajpgi.1985.249.5.g567.

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Developmental aspects of the intestinal transport of 5-methyltetrahydrofolate (5-CH3H4-PteGlu) were studied in suckling (14-day-old), weanling (22-day-old), and adult (90-day-old) rats by use of the intestinal everted-sac technique. Mucosal-to-serosal transport of 0.5 microM 5-CH3H4PteGlu was linear with time for 40-min incubation and occurred at a rate of 0.035, 0.032, and 0.010 nmol X g initial tissue wet wt-1 X min-1 for suckling, weanling, and adult rats, respectively. The transport of 5-CH3H4PteGlu in all age groups was pH dependent (maximal at pH 6) and was higher in the jejunum than in

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14

Balamurugan, Krishnaswamy, and Hamid M. Said. "Ontogenic regulation of folate transport across rat jejunal brush-border membrane." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 5 (2003): G1068—G1073. http://dx.doi.org/10.1152/ajpgi.00188.2003.

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Folate is an essential micronutrient that in mammals must be obtained from exogenous sources via intestinal absorption. Previous studies from our laboratory and others have demonstrated that folate absorption from the small intestine is mediated via the reduced-folate carrier (RFC). The goal of this study was to determine whether the initial step of folate uptake by intestinal epithelial cells, i.e., transport across the brush-border membrane (BBM) of the polarized enterocytes, is ontogenically regulated, and if so, to determine the molecular mechanism involved. Purified BBM vesicles (BBMV) is

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15

Foltzer-Jourdainne, C., J. C. Garaud, E. Nsi-Emvo, and F. Raul. "Epidermal growth factor and the maturation of intestinal sucrase in suckling rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 3 (1993): G459—G466. http://dx.doi.org/10.1152/ajpgi.1993.265.3.g459.

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The regulatory effect of epidermal growth factor (EGF) on the postnatal maturation of sucrase was investigated in the small intestine of suckling and weanling rats. Administration of EGF (0.5 micrograms.g body wt-1.day-1) to suckling rats caused a slight precocious induction of sucrase expression. In weanling rats EGF markedly stimulated sucrase activity; however, at both ages, the effect of hydrocortisone was more potent. When the glucocorticoid antagonist RU-38486 was administered to sucklings, the precocious induction of sucrase activity by hydrocortisone was inhibited by 80%. However, RU-3

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16

KARLÉN, J. "Renal response to parathyroid hormone in the weanling rat." Acta Physiologica Scandinavica 134, no. 1 (1988): 17–21. http://dx.doi.org/10.1111/j.1748-1716.1988.tb08454.x.

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17

Imaida, Katsumi, Mei-Sie Lee, Ching Y. Wang, and Charles M. King. "Carcinogenicity of dinitropyrenes in the weanling female CD rat." Carcinogenesis 12, no. 7 (1991): 1187–91. http://dx.doi.org/10.1093/carcin/12.7.1187.

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18

Raisuddin, K. P. Singh, S. I. A. Zaidi, A. K. Saxena, and P. K. Ray. "Effects of aflatoxin on lymphoid cells of weanling rat." Journal of Applied Toxicology 10, no. 4 (1990): 245–50. http://dx.doi.org/10.1002/jat.2550100404.

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19

Wedde-Beer, Katrin, Chengping Hu, Maria M. Rodriguez, and Giovanni Piedimonte. "Leukotrienes mediate neurogenic inflammation in lungs of young rats infected with respiratory syncytial virus." American Journal of Physiology-Lung Cellular and Molecular Physiology 282, no. 5 (2002): L1143—L1150. http://dx.doi.org/10.1152/ajplung.00323.2001.

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Respiratory syncytial virus (RSV) infection potentiates neurogenic inflammation in rat airways. Because some vascular effects of sensory nerves are mediated by cysteinyl leukotrienes (cysLTs), we studied whether the receptor antagonist montelukast inhibits neurogenic plasma extravasation in RSV-infected rats. Pathogen-free rats were inoculated at 2 wk (weanlings) or 12 wk (adults) of age with RSV or virus-free medium and treated with montelukast or its vehicle starting 1 day before inoculation. Five days postinoculation, we measured the extravasation of Evans blue-labeled albumin in the respir

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20

Henry, Christiani Jeyakumar, Philip R. Payne, and Amal Ghusain-Choueiri. "Relationship between tissue mobilization and storage in the rat." British Journal of Nutrition 78, no. 1 (1997): 131–41. http://dx.doi.org/10.1079/bjn19970125.

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The amount of energy mobilized or stored as protein, expressed as a proportion of the total energy stored or mobilized (defined as the P ratio, Payne & Dugdale, 1977), was investigated in the young male (rapid growth) and adult female (slow growth) rat. Energy mobilization was induced by a 3 d fast and the changes in body content of fat and lean tissues were used to estimate the fasting P ratio (Pfast). Tissue storage was subsequently effected by 17 d of refeeding and the corresponding ratio (Prefed) was calculated from the amounts of lean and fat tissue regained. The same experimental pro

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21

Dugail, I., A. Quignard-Boulange, R. Bazin, X. Le Liepvre, and M. Lavau. "Adipose-tissue-specific increase in glyceraldehyde-3-phosphate dehydrogenase activity and mRNA amounts in suckling pre-obese Zucker rats. Effect of weaning." Biochemical Journal 254, no. 2 (1988): 483–87. http://dx.doi.org/10.1042/bj2540483.

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The regulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene expression was studied during the onset of obesity in the genetically obese (fa/fa) rat by determination of GAPDH activity and hybridizable mRNA amounts in adipose tissue and liver from suckling and weanling rats. GADPH activity remained low throughout the suckling period, and a burst of activity occurred after weaning in both lean and obese pups. As early as 7 days of age, adipose tissue from pre-obese rats displayed a significant increase in enzyme activity, whereas no difference could be detected in the liver. In both s

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22

Inamdar, Shashita R., Kathleen M. Eyster та Evelyn H. Schlenker. "Selected Contribution: Estrogen receptor-α antisense decreases brain estrogen receptor levels and affects ventilation in male and female rats". Journal of Applied Physiology 91, № 4 (2001): 1886–92. http://dx.doi.org/10.1152/jappl.2001.91.4.1886.

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We hypothesized that administration of an antisense oligodeoxynucleotide (ODN) to estrogen receptor (ER)-α mRNA decreases the ER protein in the neonatal rat brain, alters the sex-specific ventilatory responses to aspartic acid in rats, and counteracts the effects of testosterone proportionate (TP) in females. One-day-old rat pups were injected intraventricularly with vehicle, antisense ER ODN, or scrambled ODN control. Additional groups of females received TP or vehicle and one of the three treatments. Brain ER protein levels were decreased by 65% at 6 h and 35% at 24 h after antisense ODN. As

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23

Gravina, Fernanda S., Clarice K. B. da Silveira, Adriano M. de Assis та ін. "Experimental Hypothyroidism Inhibits δ-Aminolevulinate Dehydratase Activity in Neonatal Rat Blood and Liver". Experimental Biology and Medicine 232, № 8 (2007): 1021–26. http://dx.doi.org/10.3181/0703-rm-66.

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The aim of this study was to investigate the potential relationship between hypothyroidism and δ-aminolevulinate dehydratase (δ-ALA-D) activity in rat blood and liver. Experimental hypothyroidism was induced in weanling rats by exposing their mothers to propylthiouracil (PTU) diluted in tap water (0.05% w/ v), ad libitum, during the lactational period (PTU group). Control (euthyroid) group included weanling rats whose mothers received just tap water, ad libitum, during the lactational period. Reverted-hypothyroid group (PTU + 3,3′,5-triiodo-L-thyronine [T3]) included weanling rats whose mother

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24

Sokol, R. J., S. F. Taylor, M. W. Devereaux, et al. "Hepatic oxidant injury and glutathione depletion during total parenteral nutrition in weanling rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 4 (1996): G691—G700. http://dx.doi.org/10.1152/ajpgi.1996.270.4.g691.

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Hepatobiliary dysfunction occurs commonly in infants on prolonged parenteral nutrition alimentation; however, the underlying mechanisms causing liver injury are poorly understood. We postulated that oxidant stress played a significant role in parenteral nutrition-induced liver abnormalities and tested this hypothesis in a rat model. Weanling male rats received 8 days of total parenteral nutrition (TPN) through a central venous catheter (TPN group), pair feeding of rat chow and placement of a central venous catheter (sham group), or ad libitum feedings of rat chow (control group). After 8 days

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25

Fukuda, Y., and A. Aperia. "Differentiation of Na+-K+ pump in rat proximal tubule is modulated by Na+-H+ exchanger." American Journal of Physiology-Renal Physiology 255, no. 3 (1988): F552—F557. http://dx.doi.org/10.1152/ajprenal.1988.255.3.f552.

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This study examines the effect of in vivo modulation of Na+-H+ exchange activity on the development of Na+-K+-ATPase in rat kidney proximal convoluted tubule (PCT) segments. To stimulate Na+-H+ exchanger (major entry pathway for Na in PCT), weanling rats were fed NH4Cl for 4 days to induce metabolic acidosis (MA). In vehicle (Vh)-fed rats PCT Na+-K+-ATPase activity (pmol Pi.mm tubule-1.h-1 +/- SE) increased from 481 +/- 78 at 16 days to 1,122 +/- 119 at 20 days. In 20-day-old chronic MA rats, PCT Na+-K+-ATPase activity was 1,717 +/- 109, i.e., significantly higher (P less than 0.01) relative t

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26

Thorne, B. Michael, Art Cook, Tim Donohoe, Steve Lyon, Denis M. Medeiros, and Chris Moutzoukis. "Aluminum toxicity and behavior in the weanling Long-Evans rat." Bulletin of the Psychonomic Society 25, no. 2 (1987): 129–32. http://dx.doi.org/10.3758/bf03330305.

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27

Rodriguez-Sargent, C., I. Torres-Negron, J. L. Cangiano, and M. Martinez-Maldonado. "Deoxycorticosterone hypertension in the intact weanling rat without salt loading." Hypertension 15, no. 2_Suppl (1990): I112. http://dx.doi.org/10.1161/01.hyp.15.2_suppl.i112.

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28

Lewis, Eric C., Robert H. Glew, James Chambers, Patrick Coyle та Jhon Coppes. "α-1-Antitrypsin metabolism in the protein-deficient weanling rat". British Journal of Nutrition 54, № 1 (1985): 63–77. http://dx.doi.org/10.1079/bjn19850093.

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1. Protein-deficient weanling rats fed on a 30 g casein/kg diet for 3 weeks lost albumin but maintained the level of serum α-1-antitrypsin, the most abundant protease inhibitor in blood.2.α-1-Antitrypsins from malnourished rats and control rats (given 250 g casein/kg diet) differed; the protease inhibitor from protein-deficient animals: (1) was more acidic, (2) appeared slightly larger (57400 v. 56000 daltons) on sodium dodecyl sulphate (SDS)-polyacrylamide gels, (3) had a more acidic Pitype and increased anodal mobility at pH 8.9, (4) bound more concanavalin-A and contained more carbohydrate,

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29

Cardenas, Silvia, Mario Scuri, Lennie Samsell, et al. "Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology 299, no. 3 (2010): L334—L344. http://dx.doi.org/10.1152/ajplung.00017.2010.

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Early-life respiratory infection with Pseudomonas aeruginosa is common in children with cystic fibrosis or immune deficits. Although many of its clinical manifestations involve neural reflexes, little information is available on the peripheral nervous system of infected airways. This study sought to determine whether early-life infection triggers a neurogenic-mediated immunoinflammatory response, the mechanisms of this response, and its relationship with other immunoinflammatory pathways. Weanling and adult rats were inoculated with suspensions containing P. aeruginosa (PAO1) coated on alginat

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30

Burrow, Keegan, Wayne Young, Niels Hammer, et al. "The Effect of the Supplementation of a Diet Low in Calcium and Phosphorus with Either Sheep Milk or Cow Milk on the Physical and Mechanical Characteristics of Bone using A Rat Model." Foods 9, no. 8 (2020): 1070. http://dx.doi.org/10.3390/foods9081070.

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This study assessed the effect of cow milk (CM) and sheep milk (SM) consumption on the micro-structure, mechanical function, and mineral composition of rat femora in a male weanling rat model. Male weanling rats were fed a basal diet with a 50% reduction in calcium and phosphorus content (low Ca/P-diet) supplemented with either SM or CM. Rats were fed for 28 days, after which the femora were harvested and stored. The femora were analyzed by μ-CT, three-point bending, and inductively coupled plasma–mass spectrometry (ICP-MS). The addition of either milk to the low Ca/P-diet significantly increa

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31

Bozzini, C., A. C. Barcelo, R. M. Alippi, T. L. Leal, and C. E. Bozzini. "The Concentration of Dietary Casein Required for Normal Mandibular Growth in the Rat." Journal of Dental Research 68, no. 5 (1989): 840–42. http://dx.doi.org/10.1177/00220345890680051801.

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To determine a suitable casein concentration for normal, undeformed mandibular growth, we placed weanling male rats on diets containing graded levels of casein between 0% and 30% for 19 days. Some weanlings were killed so that initial values could be established. Ten linear dimensions corresponding to the six skeletal units of the mandible were evaluated so that their growth rates at the end of the experimental period could be established. Other dimensions were also evaluated for study of the growth rate of the bone as a whole. The macroscopic growth of the mandible showed a sigmoidal relation

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32

Myers, B. A., M. A. Dubick, R. D. Reynolds, and R. B. Rucker. "Effect of vitamin B-6 (pyridoxine) deficiency on lung elastin cross-linking in perinatal and weanling rat pups." Biochemical Journal 229, no. 1 (1985): 153–60. http://dx.doi.org/10.1042/bj2290153.

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Weanling and perinatal rats were rendered vitamin B-6 (pyridoxine)-deficient. The rat pups were nursed from vitamin B-6-deficient or -sufficient dams and were killed at day 15 after parturition. The weanling rats were fed vitamin B-6-deficient or -sufficient diets and were killed after 5 weeks of treatment. Lung elastin from the groups of rats was then studied with respect to its content of lysine-derived cross-linking amino acids. Lung lysyl oxidase activity was also measured. B-6 deficiency decreased the number of lysine residues in elastin that were converted into the cross-linking amino ac

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33

Gratny, Linda L., Kimberly Ringer, Robert T. Hall, and Uri S. Alon. "Salt Supplementation, Growth, and Nephrocalcinosis in the Furosemide-Treated Weanling Rat." Neonatology 71, no. 1 (1997): 37–45. http://dx.doi.org/10.1159/000244395.

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34

Burman, M. A., N. J. Murawski, F. L. Schiffino, J. B. Rosen, and M. E. Stanton. "Factors governing single-trial contextual fear conditioning in the weanling rat." Behavioral Neuroscience 123, no. 5 (2009): 1148–52. http://dx.doi.org/10.1037/a0016733.

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35

Gulati, S., K. D. Gill, and R. Nath. "Effect of Cadmium on Lipid Composition of the Weanling Rat Brain." Acta Pharmacologica et Toxicologica 59, no. 2 (2009): 89–93. http://dx.doi.org/10.1111/j.1600-0773.1986.tb00139.x.

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36

Ricketts, Richard R. "Temporary intraabdominal cryptorchidism in the weanling rat leads to irreversible azoospermia." Journal of Pediatric Surgery 27, no. 6 (1992): 788. http://dx.doi.org/10.1016/s0022-3468(05)80139-3.

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37

Languille, Solène, Paulette Richer, and Bernard Hars. "Abrupt emergence of long-lasting memory in the pre-weanling rat." Behavioural Brain Research 207, no. 2 (2010): 515–19. http://dx.doi.org/10.1016/j.bbr.2009.10.035.

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38

Lejeune, Helga, and Pierre Jasselette. "DRL performance in the weanling rat: A comparison with adult subjects." Physiology & Behavior 40, no. 3 (1987): 271–78. http://dx.doi.org/10.1016/0031-9384(87)90046-1.

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39

Kort, Will J., Ineke Hekking-Weijma, and Marcel Vermeij. "Temporary intraabdominal cryptorchidism in the weanling rat leads to irreversible azoospermia." Journal of Surgical Research 51, no. 2 (1991): 138–42. http://dx.doi.org/10.1016/0022-4804(91)90084-y.

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40

Eifel, Patricia J., Christine M. Sampson, and Susan L. Tucker. "Radiation fractionation sensitivity of epiphyseal cartilage in a weanling rat model." International Journal of Radiation Oncology*Biology*Physics 19, no. 3 (1990): 661–64. http://dx.doi.org/10.1016/0360-3016(90)90493-4.

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Uauy, Ricardo, Gustavo Stringel, Rita Thomas, and Richard Quan. "Effect of Dietary Nucleosides on Growth and Maturation of the Developing Gut in the Rat." Journal of Pediatric Gastroenterology and Nutrition 10, no. 4 (1990): 497–503. http://dx.doi.org/10.1002/j.1536-4801.1990.tb10036.x.

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SummaryDietary nucleoside (DN) as a precursor for nucleic acid synthesis may be important for rapidly dividing cells, since gut epithelial cells have limited capacity for de novo purine and pyrimidine synthesis. We evaluated in a controlled blinded study the effect of added nucleosides, 0.8% by weight, given for 2 weeks, on gut growth and maturation in 20 weanling rats. Mucosal protein and DNA in the proximal intestinal segment were 50% and 77% higher, respectively, in the DN‐supplemented group (n = 10; p < 0.05). Villus height based on cell count was 25% greater in the DN group (p < 0.0

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Casasnovas, Jose, Yunhee Jo, Xi Rao, Xiaoling Xuei, Mary E. Brown, and Kok Lim Kua. "High glucose alters fetal rat islet transcriptome and induces progeny islet dysfunction." Journal of Endocrinology 240, no. 2 (2019): 309–23. http://dx.doi.org/10.1530/joe-18-0493.

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Offspring of diabetic mothers are susceptible to developing type 2 diabetes due to pancreatic islet dysfunction. However, the initiating molecular pathways leading to offspring pancreatic islet dysfunction are unknown. We hypothesized that maternal hyperglycemia alters offspring pancreatic islet transcriptome and negatively impacts offspring islet function. We employed an infusion model capable of inducing localized hyperglycemia in fetal rats residing in the left uterine horn, thus avoiding other factors involved in programming offspring pancreatic islet health. While maintaining euglycemia i

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FERVENZA, FERNANDO C., TANNY TSAO, FAY HSU, and RALPH RABKIN. "Intrarenal Insulin-Like Growth Factor-1 Axis after Unilateral Nephrectomy in Rat." Journal of the American Society of Nephrology 10, no. 1 (1999): 43–50. http://dx.doi.org/10.1681/asn.v10143.

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Abstract. It has been suggested that insulin-like growth factor-1 (IGF-1) may play a role in early compensatory renal growth. Since IGF-1 action is influenced by IGF binding proteins (IGFBP), this study was conducted to characterize the changes in gene expression not only of IGF-1 and its receptor, but also of IGFBP in the hypertrophying kidney of adult and weanling rats 1 wk after removal of the other kidney. At this time, there were distinct age-dependent changes in the renal IGF-1 axis. In the mature kidney, IGF-1 mRNA levels fell without a change in kidney IGF-1 peptide content. Likewise,

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McMillen, Shasta A., Eric B. Nonnecke, and Bo Lönnerdal. "Trace Element Interactions, Inflammatory Signaling, and Male Sex Implicated in Reduced Growth Following Excess Oral Iron Supplementation in Pre-Weanling Rats." Nutrients 14, no. 19 (2022): 3913. http://dx.doi.org/10.3390/nu14193913.

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Iron supplements are frequently provided to infants in high-income countries despite low incidence of iron deficiency. There is growing concern regarding adverse health and development outcomes of excess iron provision in early life. Excess iron may directly damage developing organs through the formation of reactive oxygen species, alter systemic inflammatory signaling, and/or dysregulate trace mineral metabolism. To better characterize the in vivo effects of excess iron on development, we utilized a pre-weanling rat pup model. Lewis rat litters were culled to eight pups (four males and four f

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Payne, R. M., H. F. Sims, M. L. Jennens, and M. E. Lowe. "Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development." American Journal of Physiology-Gastrointestinal and Liver Physiology 266, no. 5 (1994): G914—G921. http://dx.doi.org/10.1152/ajpgi.1994.266.5.g914.

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We report the cDNA sequences of rat colipase, rat pancreatic lipase (rPL), and a rat pancreatic lipase-related protein (rPLRP). Comparison to the human PLRP cDNA suggests that the isolated clone encodes rPLRP-2. Both cDNA and a third cDNA encoding rPLRP-1 are secreted from Sf9 cells infected with recombinant baculovirus. rPL and rPLRP-2 hydrolyze triolein, 8.0 and 4.4 mumol.min-1.microgram-1, respectively. They are inhibited by bile salts, and activity is restored by (pro)colipase. PLRP-1 has barely detectable activity against triolein, even with (pro)colipase present. The pattern of mRNA expr

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Flores, C. A., P. M. Brannon, M. A. Wells, M. Morrill, and O. Koldovsky. "Effect of diet on triolein absorption in weanling rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 258, no. 1 (1990): G38—G44. http://dx.doi.org/10.1152/ajpgi.1990.258.1.g38.

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To determine the effect of altered dietary fat intake on the rate of fat absorption in the intact animal, we fed male weanling rats either a high fat-low carbohydrate (HF-LC) (calories: 67% fat, 10% carbohydrate, 20% protein) or low fat-high carbohydrate (LF-HC) (calories: 10% fat, 67% carbohydrate, 20% protein) diet for 8 days. Absorption of [14C]triolein was estimated by determining 1) 14CO2 expiration in breath, 2) intestinal triglyceride output using Triton WR-1339, an inhibitor of lipoprotein lipase, and 3) quantitating the disappearance of labeled triolein from the gastrointestinal tract

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Pácha, J., та I. Mikšík. "11β-Hydroxysteroid dehydrogenase in developing rat intestine". Journal of Endocrinology 148, № 3 (1996): 561–66. http://dx.doi.org/10.1677/joe.0.1480561.

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Abstract The enzyme 11β-hydroxysteroid dehydrogenase (11β-OHSD) prevents the binding of corticosterone to mineralocorticoid receptors by reversible conversion of biologically active corticosterone to inactive 11-dehydrocorticosterone. To clarify the relationship between high plasma concentrations of corticosterone during weaning and high activity of intestinal transport pathways that are induced by aldosterone in immature intestine, we have studied the distribution, developmental pattern and regulation of 11 β-OHSD in intestinal segments that possess mineralocorticoid target epithelium. Dehydr

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McHugh, Nansie A., Haydee M. Vercesi, Robert W. Egan, and John A. Hey. "In vivo rat assay: bone remodeling and steroid effects on juvenile bone by pQCT quantification in 7 days." American Journal of Physiology-Endocrinology and Metabolism 284, no. 1 (2003): E70—E75. http://dx.doi.org/10.1152/ajpendo.00102.2002.

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Anesthetized Sprague-Dawley weanling rats were scanned for bone mineral density (BMD) values after 7 days of treatment to determine whether resorption/growth at the proximal tibia can be quantified by peripheral quantitative computed tomography scanning techniques. Because the weanling rat is in a rapid growth stage, all groups showed significant increases in change from baseline values of BMD. Bisphosphonate treatment produced significant dose-related changes in BMD with average increases of 195 and 241% (10 and 20 μg/kg) vs. 86% in control rats. We further characterized this model to determi

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Younoszai, M. Kabir, Carolyn Smith, and Michael H. Finch. "Comparison of In Vitro Jejunal Uptake of L‐Valine and L‐Lysine in the Rat During Maturation." Journal of Pediatric Gastroenterology and Nutrition 4, no. 6 (1985): 992–97. http://dx.doi.org/10.1002/j.1536-4801.1985.tb08998.x.

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The maturational characteristics and patterns of absorption of the neutral amino acid L‐valine were compared with those of the basic amino acid L‐lysine using in vitro preparations of everted sacs obtained from the jejunum of suckling (2 weeks old), weanling (3 weeks old), and adolescent (6 weeks old) rats. Absorption rates determined as net transport into sac fluid and mucosal uptake ($mUmol/h/g protein or weight of mucosal scrapings) for both valine and lysine were greater in the suckling than in the weanling or adolescent rats. This appeared to be true for both the carrier‐mediated and the

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Hu, Chengping, Katrin Wedde-Beer, Alexander Auais, Maria M. Rodriguez, and Giovanni Piedimonte. "Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology 283, no. 2 (2002): L494—L502. http://dx.doi.org/10.1152/ajplung.00414.2001.

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Nerve growth factor (NGF) controls sensorineural development and responsiveness and modulates immunoinflammatory reactions. Respiratory syncytial virus (RSV) potentiates the proinflammatory effects of sensory nerves in rat airways by upregulating the substance P receptor, neurokinin 1 (NK1). We investigated whether the expression of NGF and its trkA and p75 receptors in the lungs is age dependent, whether it is upregulated during RSV infection, and whether it affects neurogenic inflammation. Pathogen-free rats were killed at 2 (weanling) to 12 (adult) wk of age; in addition, subgroups of rats

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