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Journal articles on the topic 'In-vivo testing'

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Author: Grafiati
Published: 9 March 2023
Last updated: 14 March 2023

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1

Bautista, Levylee G., Dawn Grace E. Santos, Ghafoor A. Haque, Jr. I, Aishwarya V. Veluchamy, Jesusa E. Santos, and Rodolfo T. Rafael. "In Vivo Genotoxicity Testing of Sesbania grandiflora (Katuray) Flower Methanol Extract." International Journal of Pharma Medicine and Biological Sciences 11, no. 1 (January 2022): 14–19. http://dx.doi.org/10.18178/ijpmbs.11.1.14-19.

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2

Cook, Paul R. "In vivo testing and immunotherapy." Current Opinion in Otolaryngology & Head and Neck Surgery 2 (April 1994): 118–27. http://dx.doi.org/10.1097/00020840-199404000-00006.

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3

Al-hadede, Lamees Thamer, Taghreed H. AL-Sadoon, Basma A. Jasim, and Huda Khmees Akaar. "In Vivo Testing of Coated Nanoparticles as Medication Delivery and Liver Integrity Monitoring in Mice's." NeuroQuantology 20, no. 3 (March 31, 2022): 318–24. http://dx.doi.org/10.14704/nq.2022.20.3.nq22282.

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The study's goal is to assay the effect of using therapeutic nanoparticles on the liver. The study involves the estimation of aminotransferase ALT, AST and alkaline phosphate ALP levels in patients before and after using nanoparticles. Gold nanoparticles (Gnps) were created using a chemical method, then coated with polyethylene glycol (Peg), followed by Ultra violet spectrophotometry, transmission electron microscopy (TEM), and surface charge studies to determine their sizes, then were investigate the effect of using therapeutic nanoparticles on the liver. The results show that before coating with Peg, the size of Gnps was 22.65 and 23.82 nm, while after coating with Peg, the size of Gnps was 76.50 and 80.15 nm. The maximum absorption was at 515.5 nm and became 530.5 nm when using UV, and it was -29.65 and became -9.4 when using zeta potential, experiments are ongoing for (60) days. The result revealed that the liver enzymes (AST and ALT) has a significant effect when injecting Gnps. While the effect was less on both liver enzymes (AST and ALT) when injecting Gnps + Peg.
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4

Ownby, Dennis R. "Allergy Testing: In Vivo Versus In Vitro." Pediatric Clinics of North America 35, no. 5 (October 1988): 995–1009. http://dx.doi.org/10.1016/s0031-3955(16)36544-0.

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5

Maurer, Th. "Phototoxicity testing—in vivo and in vitro." Food and Chemical Toxicology 25, no. 5 (May 1987): 407–14. http://dx.doi.org/10.1016/0278-6915(87)90177-3.

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6

Bolotova, К. S., O. V. Buyuklinskaya, А. S. Chistyakova, О. V. Travina, and D. G. Chukhchin. "PRODUCTION AND IN VIVO TOXICITY TESTING OF MICROCRYSTALLINE CELLULOSE DERIVED FROM BACTERIAL CELLULOSE." Human Ecology, no. 2 (February 13, 2018): 21–25. http://dx.doi.org/10.33396/1728-0869-2018-2-21-25.

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7

Levorová, J., J. Dušková, M. Drahoš, R. Vrbová, J. Kubásek, D. Vojtěch, M. Bartoš, L. Dugová, D. Ulmann, and R. Foltán. "Biodegradability of Metal Alloys: in vivo Testing." Česká stomatologie/Praktické zubní lékařství 117, no. 4 (December 1, 2017): 79–84. http://dx.doi.org/10.51479/cspzl.2017.014.

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8

Levorová, J., J. Dušková, M. Drahoš, R. Vrbová, J. Kubásek, D. Vojtěch, M. Bartoš, L. Dugová, D. Ulmann, and R. Foltán. "Biodegradability of Metal Alloys: in vivo Testing." Česká stomatologie/Praktické zubní lékařství 117, no. 4 (December 1, 2017): 79–84. http://dx.doi.org/10.51479/cspzl.2017.014.

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9

Szycher, Michael, Andrew M. Reed, and Arthur A. Siciliano. "In vivo Testing of a Biostable Polyurethane." Journal of Biomaterials Applications 6, no. 2 (October 1991): 110–30. http://dx.doi.org/10.1177/088532829100600202.

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10

Kischkel, Sabine, Stefan Bergt, Beate Brock, Johan von Grönheim, Anne Herbst, Marc-Jonas Epping, Georg Matheis, et al. "In Vivo Testing of Extracorporeal Membrane Ventilators." ASAIO Journal 63, no. 2 (2017): 185–92. http://dx.doi.org/10.1097/mat.0000000000000465.

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11

Kostic, Milena, Stevo Najman, Dragan Mihailovic, Nebojsa Krunic, Nikola Gligorijevic, Jasmina Gligorijevic, Marko Igic, and Nikola Marinkovic. "Denture base resins biocompatibility testing in vivo." Vojnosanitetski pregled 75, no. 11 (2018): 1094–100. http://dx.doi.org/10.2298/vsp170112045k.

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Background/Aim. The wearing of acrylic dentures is the cause of the inflammatory reaction of the oral mucosa. The aim of this study was to investigate the response of rat tissues to subcutaneous and intramuscular implantation of different acrylic samples, by histopathological analysis of the tissue. Methods. The study included two samples of hard and three samples of soft acrylic resins (heat and cold polymerized), that were subcutaneously and intramuscularly implanted in rats tissues. Implantation tests were designed to test the biological response of the surrounding tissue to the tested materials after their application for the period of two weeks and the period of four months. Results. After two weeks, regardless of the type of implantation, histopathological analysis showed an acute inflammatory response. There was an intense hyperplasia of inflammatory cells, multiplication of connective tissue as well as formation of many new blood vessels. The highest level of inflammatory changes was observed after the application of cold-polymerized resins. A lower intensity of inflammation in the case of heat polymerised resin was the result of its more complete polymerization. After the second observation period, fibrotic capsules were formed around the implanted samples indicating a chronic course of the inflammatory process. Less visible signs of inflammation and chronicity of the processes indicate that with time, i.e. with the length of the observation period, reduces inflammation. Conclusion. The subcutaneous and intramuscular implantation of acrylic resins material samples led to inflammatory response whose intensity was decreased over time. Heat polymerized resin was a biologically more acceptable in comparison to the cold polymerized acrylates.
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12

Seok, Seung-Hyeok, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, Yi-Rang Na, Kyoung-Jin Noh, Sung-Hoon Park, Hyun-Kyoung Lee, Byoung-Hee Lee, and Jae-Hak Park. "In vivo alternative testing with zebrafish in ecotoxicology." Journal of Veterinary Science 9, no. 4 (2008): 351. http://dx.doi.org/10.4142/jvs.2008.9.4.351.

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13

Stratton, Charles W. "In Vitro Susceptibility Testing Versus In Vivo Effectiveness." Medical Clinics of North America 90, no. 6 (November 2006): 1077–88. http://dx.doi.org/10.1016/j.mcna.2006.07.003.

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14

Højelse, Flemming. "Preclinical Safety Assessment: In vitro - in vivo Testing." Pharmacology & Toxicology 86 (June 2000): 6–7. http://dx.doi.org/10.1034/j.1600-0773.2000.d01-2.x.

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15

Gouget, B., and J. Fonteneau. "Biocapteurs in vitro, ex vivo, in vivo et “point of care testing (POCT)”." Revue Française des Laboratoires 1997, no. 292 (April 1997): 73–76. http://dx.doi.org/10.1016/s0338-9898(97)80041-8.

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16

Kjellstrand, Per, Eva Lindqvist, and Carin Nilsson-Thorell. "Toxicity Testing of Polymer Materials for Dialysis Equipment: Reconsidering In Vivo Testing." Alternatives to Laboratory Animals 28, no. 3 (May 2000): 495–502. http://dx.doi.org/10.1177/026119290002800307.

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17

Pretto, Francesca, and Rex E. FitzGerald. "In vivo safety testing of Antibody Drug Conjugates." Regulatory Toxicology and Pharmacology 122 (June 2021): 104890. http://dx.doi.org/10.1016/j.yrtph.2021.104890.

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18

Heywood, Ralph. "Book Review: Handbook of In Vivo Toxicity Testing." Alternatives to Laboratory Animals 18, no. 1_part_1 (November 1990): 354–55. http://dx.doi.org/10.1177/026119299001800136.1.

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19

van Huygevoort, Ton, Judith Latour, and Harry Emmen. "A standardized approach for in vivo photosafety testing." Toxicology Letters 229 (September 2014): S168—S169. http://dx.doi.org/10.1016/j.toxlet.2014.06.579.

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20

Moss, McKenze J., and Patricia L. Clark. "Testing mechanisms for homomeric protein assembly in vivo." Biophysical Journal 122, no. 3 (February 2023): 466a—467a. http://dx.doi.org/10.1016/j.bpj.2022.11.2502.

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21

Smart, Brian A. "ALLERGY TESTING USING IN VIVO AND IN VITRO TECHNIQUES." Radiologic Clinics of North America 19, no. 1 (February 1999): 35–45. http://dx.doi.org/10.1016/s0033-8389(22)00156-7.

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22

Kelso, John M. "In vivo and in vitro testing with PEGylated nanoparticles." Journal of Allergy and Clinical Immunology 148, no. 3 (September 2021): 902. http://dx.doi.org/10.1016/j.jaci.2021.06.004.

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23

Smart, Brian A. "ALLERGY TESTING USING IN VIVO AND IN VITRO TECHNIQUES." Immunology and Allergy Clinics of North America 19, no. 1 (February 1999): 35–45. http://dx.doi.org/10.1016/s0889-8561(05)70052-7.

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24

Yüzbaşıoğlu, Deniz, Fatma Ünal, Serkan Yılmaz, Hüseyin Aksoy, and Mustafa Çelik. "Genotoxicity testing of fluconazole in vivo and in vitro." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 649, no. 1-2 (January 2008): 155–60. http://dx.doi.org/10.1016/j.mrgentox.2007.08.012.

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25

Krul, Cyrille, Wilfred Maas, Richard van Meeuwen, Nico de Vogel, and Marie Jose Steenwinkel. "In vivo photogenotoxicity testing, bridging the gap between in vitro photogenotoxicity and photocarcinogenicity testing." Toxicology 226, no. 1 (September 2006): 25. http://dx.doi.org/10.1016/j.tox.2006.05.039.

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26

Zhang, Weisheng, Min Chen, David B. West, and Anthony F. Purchio. "Visualizing Drug Efficacy In Vivo." Molecular Imaging 4, no. 2 (April 1, 2005): 153535002005051. http://dx.doi.org/10.1162/15353500200505109.

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Many enzymes are therapeutic targets for drug discovery, whereas other enzymes are important for understanding drug metabolism and pharmacokinetics during compound testing in animals. Testing of drug efficacy and metabolism in an animal model requires the measurement of disease endpoints as well as assays of enzyme activity in specific tissues at selected time points during treatment. This requires the removal of tissue and biochemical assays. Techniques to noninvasively assess drug effects on enzyme activity using imaging technology would facilitate understanding of drug efficacy, pharmacokinetics, and drug metabolism. Using a commercially available cytochrome P−450 3A substrate whose oxidized product is a luciferase substrate, we show for the first time that cytochrome P−450 enzyme activity can be measured in vivo in real time by bioluminescent imaging. This imaging approach could be applicable to study drug effects on therapeutic target enzymes, as well as drug metabolism enzymes.
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27

Kikuchi, Yasumoto. "Studies of in vivo genotoxicity testing; its importance and incorporation into guideline." Environmental Mutagen Research 25, no. 2 (2003): 101–7. http://dx.doi.org/10.3123/jems.25.101.

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28

Mirkhalaf, Mohammad, Aiken Dao, Aaron Schindeler, David G. Little, Colin R. Dunstan, and Hala Zreiqat. "Personalized Baghdadite scaffolds: stereolithography, mechanics and in vivo testing." Acta Biomaterialia 132 (September 2021): 217–26. http://dx.doi.org/10.1016/j.actbio.2021.03.012.

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29

Ellender, Graham, Sophie A. Feik, and Claudia Gaviria. "The biocompatibility testing of some dental amalgams in vivo." Australian Dental Journal 35, no. 6 (December 1990): 497–504. http://dx.doi.org/10.1111/j.1834-7819.1990.tb04679.x.

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30

Gandy, Sam. "Testing the amyloid hypothesis of Alzheimer's disease in vivo." Lancet Neurology 9, no. 4 (April 2010): 333–35. http://dx.doi.org/10.1016/s1474-4422(10)70055-7.

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31

Rizzo, Larissa Y., Susanne K. Golombek, Marianne E. Mertens, Yu Pan, Dominic Laaf, Janine Broda, Jabadurai Jayapaul, et al. "In vivo nanotoxicity testing using the zebrafish embryo assay." Journal of Materials Chemistry B 1, no. 32 (2013): 3918. http://dx.doi.org/10.1039/c3tb20528b.

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32

Fussell, Karma C., Steffen Schneider, Stephanie Melching-Kollmuss, Sibylle Groeters, Volker Strauss, Benazir Siddeek, Mohamed Benahmed, Markus Frericks, and Bennard van Ravenzwaay. "Testing mixtures in vivo at human-relevant exposure levels." Toxicology Letters 221 (August 2013): S25. http://dx.doi.org/10.1016/j.toxlet.2013.06.088.

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33

Lynde, Thomas A., Eric S. Fried, James C. Burns, and John W. Unger. "In vivo testing of an experimental endosseous implant design." Journal of Oral and Maxillofacial Surgery 54, no. 10 (October 1996): 1212–15. http://dx.doi.org/10.1016/s0278-2391(96)90354-7.

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34

Hernández, Félix, Miguel Dı́az-Hernández, Jesús Avila, and José J. Lucas. "Testing the ubiquitin–proteasome hypothesis of neurodegeneration in vivo." Trends in Neurosciences 27, no. 2 (February 2004): 66–69. http://dx.doi.org/10.1016/j.tins.2003.12.002.

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35

Monahan, Thomas S., Mauricio A. Contreras, Jeffrey A. Kalish, Matthew D. Phaneuf, Donald J. Dempsey, Martin J. Bide, Richard N. Mitchell, Frank W. LoGerfo, and Allen D. Hamdan. "In vivo testing of an infection resistant prosthetic material." Journal of the American College of Surgeons 199, no. 3 (September 2004): 112. http://dx.doi.org/10.1016/j.jamcollsurg.2004.05.252.

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36

Fischer, A., A. Meißner, H. Brauer, and S. Weiß. "Stent fatigue testing according to in vivo strain cycles." Journal of Biomechanics 39 (January 2006): S591. http://dx.doi.org/10.1016/s0021-9290(06)85451-5.

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37

Monahan, Thomas S., Matthew D. Phaneuf, Mauricio A. Contreras, Nicholas D. Andersen, Alexandra Popescu-Vladimir, Martin J. Bide, Donald J. Dempsey, Richard N. Mitchell, Allen D. Hamdan, and Frank W. LoGerfo. "In Vivo Testing of an Infection-Resistant Annuloplasty Ring." Journal of Surgical Research 130, no. 1 (January 2006): 140–45. http://dx.doi.org/10.1016/j.jss.2005.06.006.

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38

Lokugamage, Melissa P., Cory D. Sago, and James E. Dahlman. "Testing thousands of nanoparticles in vivo using DNA barcodes." Current Opinion in Biomedical Engineering 7 (September 2018): 1–8. http://dx.doi.org/10.1016/j.cobme.2018.08.001.

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39

Masuda‐Herrera, Melisa J., Krista L. Dobo, Michelle O. Kenyon, Julia D. Kenny, Sheila M. Galloway, Patricia A. Escobar, M. Vijayaraj Reddy, et al. "In Vivo Mutagenicity Testing of Arylboronic Acids and Esters." Environmental and Molecular Mutagenesis 60, no. 9 (August 17, 2019): 766–77. http://dx.doi.org/10.1002/em.22320.

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40

Danni, He, MS, Ji, MD Qiao, Lin, MD Huitong, Liang, MM Xuankun, Li, MM Lujing, Liang, MM Fengping, Wang, MM Xianxiang, Yuan, MS Kun, and Xu, MD Zuofeng. "A New-Designed Microwave Ablation System: Testing in ex vivo and in vivo Liver Model." ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY 5, no. 1 (2021): 39. http://dx.doi.org/10.37015/audt.2021.200014.

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41

Sherman, Ethan G., Patrick J. Antonelli, and Roger Tran-Son-Tay. "In vitro testing of tympanostomy tube occlusion." Otolaryngology–Head and Neck Surgery 141, no. 5 (November 2009): 598–602. http://dx.doi.org/10.1016/j.otohns.2009.08.019.

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Objective: Tympanostomy tubes (TTs) are commonly rendered nonfunctional by mucus plug formation. The purpose of this study was to determine whether an in vitro model could be developed to assess TT plug formation with results consistent with human trials. Study Design: An ear chamber was designed to mimic middle ear air and mucus flow conditions in post-TT otorrhea. TT occlusion was tested and correlated to published in vivo results. Methods: TTs that had previously been studied in vivo (Goode “T” and Reuter Bobbin collar buttons) were placed in the model chamber. Pooled, homogenized human middle ear mucus and an analog, egg white, were delivered at 80 μL per hour through the TTs. An air bolus was delivered every two minutes to simulate swallowing. Chamber pressure was monitored over 2.5 hours. Occlusion was determined by a pressure peak and visual confirmation. Results: Obstruction was found in 60 percent of the Reuter Bobbin and 40 percent of the Goode TTs using the mucus analog. These results are similar to those reported from previous in vivo studies. No plugging was reported for either TT using homogenized human ear mucus. Conclusions: The in vitro TT chamber simulates the in vivo environment and yields results consistent with in vivo observations. This model system may allow for rapid prototyping and evaluation of new TTs that may be less vulnerable to occlusion.
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42

Furse, Alex, Brock J. Miller, Claire McCann, John R. Kachura, Michael A. Jewett, and Michael D. Sherar. "Radiofrequency Coil for the Creation of Large Ablations: Ex Vivo and In Vivo Testing." Journal of Vascular and Interventional Radiology 23, no. 11 (November 2012): 1522–28. http://dx.doi.org/10.1016/j.jvir.2012.08.015.

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43

NONAMI, Toru. "In Vivo and In Vitro Testing of Diopside for Biomaterial." Journal of Society of Materials Engineering for Resources of Japan 8, no. 2 (1995): 12–18. http://dx.doi.org/10.5188/jsmerj.8.2_12.

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44

Liu, Changrong, Yong-Xin Guo, Rangarajan Jegadeesan, and Shaoqiu Xiao. "In Vivo Testing of Circularly Polarized Implantable Antennas in Rats." IEEE Antennas and Wireless Propagation Letters 14 (2015): 783–86. http://dx.doi.org/10.1109/lawp.2014.2382559.

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45

Rieder, Michael J. "IN VIVO AND IN VITRO TESTING FOR ADVERSE DRUG REACTIONS." Pediatric Clinics of North America 44, no. 1 (February 1997): 93–111. http://dx.doi.org/10.1016/s0031-3955(05)70465-x.

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46

Ebo, Didier G., Christel Mertens, Marissa Braes, Isabel Mennes, Chris H. Bridts, and Vito Sabato. "Clindamycin anaphylaxis confirmed by in vivo and in vitro testing." Journal of Allergy and Clinical Immunology: In Practice 7, no. 1 (January 2019): 331–33. http://dx.doi.org/10.1016/j.jaip.2018.06.008.

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47

Verity, Erin E., Kathy Stewart, Kirsten Vandenberg, Chi Ong, and Steven Rockman. "Potency Testing of Venoms and Antivenoms in Embryonated Eggs: An Ethical Alternative to Animal Testing." Toxins 13, no. 4 (March 24, 2021): 233. http://dx.doi.org/10.3390/toxins13040233.

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Venoms are complex mixtures of biologically active molecules that impact multiple physiological systems. Manufacture of antivenoms (AVs) therefore requires potency testing using in vivo models to ensure AV efficacy. As part of ongoing research to replace small animals as the standard model for AV potency testing, we developed an alternate in vivo method using the embryonated egg model (EEM). In this model, the survival of chicken embryos envenomated in ovo is determined prior to 50% gestation, when they are recognized as animals by animal welfare legislation. Embryos were found to be susceptible to a range of snake, spider, and marine venoms. This included funnel-web spider venom for which the only other vertebrate, non-primate animal model is newborn mice. Neutralization of venom with standard AV allowed correlation of AV potency results from the EEM to results from animal assays. Our findings indicate that the EEM provides an alternative, insensate in vivo model for the assessment of AV potency. The EEM may enable reduction or replacement of the use of small animals, as longer-term research that enables the elimination of animal use in potency testing continues.
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48

Thybaud, Véronique, James T. MacGregor, Lutz Müller, Riccardo Crebelli, Kerry Dearfield, George Douglas, Peter B. Farmer, et al. "Strategies in case of positive in vivo results in genotoxicity testing." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 723, no. 2 (August 2011): 121–28. http://dx.doi.org/10.1016/j.mrgentox.2010.09.002.

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49

CARLSSON, L. "In vitro and in vivo models for testing arrhythmogenesis in drugs." Journal of Internal Medicine 259, no. 1 (January 2006): 70–80. http://dx.doi.org/10.1111/j.1365-2796.2005.01590.x.

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50

MacKenzie, Hugh A., Helen S. Ashton, Stephen Spiers, Yaochun Shen, Scott S. Freeborn, John Hannigan, John Lindberg, and Peter Rae. "Advances in Photoacoustic Noninvasive Glucose Testing." Clinical Chemistry 45, no. 9 (September 1, 1999): 1587–95. http://dx.doi.org/10.1093/clinchem/45.9.1587.

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Abstract We report here on in vitro and in vivo experiments that are intended to explore the feasibility of photoacoustic spectroscopy as a tool for the noninvasive measurement of blood glucose. The in vivo results from oral glucose tests on eight subjects showed good correlation with clinical measurements but indicated that physiological factors and person-to-person variability are important. In vitro measurements showed that the sensitivity of the glucose measurement is unaffected by the presence of common blood analytes but that there can be substantial shifts in baseline values. The results indicate the need for spectroscopic data to develop algorithms for the detection of glucose in the presence of other analytes.
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