Relevant bibliographies by topics / In vivo

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'In vivo'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2024

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Journal articles on the topic "In vivo"

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Lenchenko, Ekaterina M., Dmitry A. Blumenkrants, Vladislav V. Ponomarev, Inna B. Pavlova, and Galina S. Tolmacheva. "METHODOLOGICAL ASPECTS OF RESEARCH OF COMPOSITION OF BIOFILMS in vitro, ex vivo, in vivo." Problems of veterinary sanitation, hygiene and ecology 1, no. 41 (2022): 73–82. http://dx.doi.org/10.36871/vet.san.hyg.ecol.202201009.

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The article presents the general patterns of formation of a three-dimensional multilayer heterogeneous structure biofilms in vitro, ex vivo, in vivo. It was found, that the mass fraction of cells of biofilms was 86,8-91,4%, of the matrix – 8,9-13,2%, which is due to the structure of the cell wall of microorganisms synthesizing the extracellular matrix. The advantages of transmission and scanning electron microscopy are the visualization of L-shapes and the quantitative assessment of the diameter, perimeter, height, area, volume and chemical composition of cells and the extracellular matrix of microorganisms. Laser modulation interference microscopy made it possible to study biofilms in real time without fixing and staining microorganisms; phase-contrast microscopy – intrapopulation and interpopulation interactions depending on changes in the pH of the environment, oxygen content and other chemical and physical factors. Fluorescent microscopy is a promising method for detection of non-culturable viable cells of microorganisms. The use a modified Gram stain, the use of solution of «Crocus sativus» made it possible to differentiate gram-negative and gram-positive microorganisms and to assess the degree of repair of tissue. The developed new methodological approach made it possible to scientifically substantiate and experimentally confirm the effectiveness of the use of nutrient media containing components for the repair of the cell wall of microorganisms.
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Shishatskaya, Ekaterina I. "Biodegradation of PHA in vivo." Journal of Siberian Federal University. Biology 9, no. 1 (March 2016): 21–32. http://dx.doi.org/10.17516/1997-1389-2016-9-1-21-32.

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van Luijk, S. J., F. Scheele, and C. P. M. van der Vleuten. "Toetsing in vivo bij ‘In VIVO’." Tijdschrift voor Medisch Onderwijs 27, no. 6 (December 2008): 279–87. http://dx.doi.org/10.1007/bf03078290.

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Mitterhauser, Markus, Stefan Toegel, Wolfgang Wadsak, Rupert R. Lanzenberger, Leonhard-Key Mien, Claudia Kuntner, Thomas Wanek, et al. "Pre vivo, ex vivo and in vivo evaluations of [68Ga]-EDTMP." Nuclear Medicine and Biology 34, no. 4 (May 2007): 391–97. http://dx.doi.org/10.1016/j.nucmedbio.2007.03.002.

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Huven, Paula. "Reativar o vivo, atravessar a floresta." MODOS: Revista de História da Arte 7, no. 1 (February 13, 2023): 344–68. http://dx.doi.org/10.20396/modos.v7i1.8670588.

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A partir de variadas expressões poéticas – fotográfica, cinematográfica, pictórica e literária – proponho contornar a ideia de vivo. Minha série fotográfica Água viva desenha a aproximação de uma menina com as águas correntes da cachoeira. A criança entra em contato com a matéria do mundo e com o invisível da natureza, sem margens que os distingam. Naomi Kawase, em seu filme Floresta dos Lamentos, mostra-nos que atravessar a floresta é, necessariamente, ser atravessada por ela. A artista Wilma Martins constrói pictoricamente irrupções da floresta no cenário domiciliar e, assim, ela dá forma ao vínculo entre o real e o imaginário; entre o selvagem e o domesticado. A personagem G.H., de Clarice Lispector, vive uma epifania a partir do encontro com uma barata – ser arcaico, remoto, imemorial, travessia íntima e subjetiva que faz emergir o mais primitivo de si. Entre o mundo que olhamos e o que vemos, o visível e o invisível, a matéria e o espírito, humano e não humano, somos atravessados pela energia do vivo. Reativar, palavra-chave no vocabulário da filósofa belga Isabelle Stengers, leva-nos de volta em direção ao vínculo com os deuses, os espíritos, a terra e, com estas alianças, reativar o vivo se compõe.
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Ilinskaya, O. N., and H. Fret. "Genotoxical effects of ribonuclease in vivo." Biopolymers and Cell 16, no. 4 (July 20, 2000): 270–74. http://dx.doi.org/10.7124/bc.000570.

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Gurova, S. V., T. M. Kecheryukova, A. S. Goncharova, E. N. Kolesnikov, M. A. Kozhushko, and M. Z. Tatimov. "MODELS OF LIVER CANCER IN VIVO." Современные проблемы науки и образования (Modern Problems of Science and Education), no. 4 2023 (2023): 14. http://dx.doi.org/10.17513/spno.32707.

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Chen, Gong. "In vivo confusion over in vivo conversion." Molecular Therapy 29, no. 11 (November 2021): 3097–98. http://dx.doi.org/10.1016/j.ymthe.2021.10.017.

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Borgström, L. "In vitro, ex vivo, in vivo veritas." Allergy 54, s49 (March 1999): 88–92. http://dx.doi.org/10.1111/j.1398-9995.1999.tb04394.x.

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Tümmler, Burkhard. "In-vivo and ex-vivo functional assessment." Journal of Cystic Fibrosis 3 (August 2004): 149–50. http://dx.doi.org/10.1016/j.jcf.2004.05.031.

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Dissertations / Theses on the topic "In vivo"

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Gerez, Juliana Rubira. "Fusariotoxinas em suínos : efeitos tóxicos in vivo e ex vivo." Universidade Estadual de Londrina. Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência Animal, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000194847.

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Com objetivo de avaliar os efeitos sistêmicos da contaminação alimentar por micotoxinas, enfatizando aspectos morfológicos e imunohistoquímicos, dois experimentos foram realizados. No primeiro experimento, 20 leitões de cinco semanas de idade foram divididos em quatro grupos experimentais. Os animais receberam durante 28 dias os seguintes tratamentos: dieta controle, dieta contaminada com desoxinivalenol (DON) (1,5 mg/kg), dieta contaminada com DON (2 mg/kg) + nivalenol (NIV) (1,3 mg/kg) + zearalenona (ZEA) (1,5 mg/kg) ou dieta contaminada com DON (3 mg/kg) + NIV (1,3 mg/kg) + ZEA (1,5 mg/kg). A dieta mono-contaminada não alterou o ganho de peso, entretanto os animais expostos à dieta multi-contaminada apresentaram uma diminuição significativa no ganho de peso final. A ingestão crônica das dietas contaminadas induziu alterações histológicas no intestino, como atrofia e fusão de vilosidades, diminuição na altura de vilosidades e na profundidade de criptas, redução no número de células caliciformes e linfócitos. O fígado, os linfonodos mesentéricos e o baço dos animais expostos às dietas contaminadas apresentaram um aumento significativo de lesões. Um aumento significativo na expressão de caspase-3 nos órgãos linfoides foi observado nos animais que receberam as dietas contaminadas. No segundo experimento, 12 leitões de 4 a 5 semanas de idade foram eutanasiados para obtenção de explantes jejunais, os quais foram expostos a cinco tratamentos por 4 horas, sob agitação constante a 37ºC em atmosfera umidificada a 5% de CO2. No tratamento controle foi utilizado meio de cultura William E sem ou com o diluente DMSO a 0,1%. Nos demais tratamentos os explantes foram expostos a DON, NIV (1, 3, 10 µM) e fusarenona X (FX) (0,3, 1 e 3 µM). Após incubação, as amostras de tecidos foram processadas histologicamente e analisadas utilizando-se escore histológico. Não foi observada diferença significativa no escore histológico entre amostras não incubadas e incubadas com meio de cultura na ausência ou presença de DMSO. As principais alterações observadas nos explantes expostos às micotoxinas foram atrofia de vilosidades, células epiteliais cúbicas e pavimentosas, edema na lâmina própria e desnudamento apical com perda de enterócitos. Os tratamentos individuais com DON, NIV e FX induziram uma diminuição do escore histológico a partir das doses de 3µM, 1µM e 0,3 µM, respectivamente. Em conclusão, os dados obtidos fornecem uma melhor compreensão dos efeitos das fusariotoxinas isoladas ou em combinação sobre a morfologia intestinal e de órgãos linfoides, as quais podem predispor os animais a infecções secundárias.
In order to evaluate the systemic effects of food contamination by mycotoxins, emphasizing morphological and immunohistochemical aspects, two experiments were conducted. In the first experiment, 20 5-week-old piglets were randomly assigned to four groups. The animals received for 28 days the following treatments: control diet, a diet contaminated with deoxynivalenol DON (1.5 mg/kg), a diet contaminated with DON (2.0 mg/kg) + nivalenol (NIV) (1.3 mg/kg) + zearalenone (ZEA) (1.5 mg/kg) or a diet contaminated with DON (3.0 mg/kg) + NIV (1.3 mg/kg) + ZEA (1.5 mg/kg). The mono-contaminated diet showed no difference in weight gain, however the animals fed the multi–contaminated diets presented a significant decrease in final weight gain. The chronic ingestion of these contaminated diets induced histological changes in the intestine as show by atrophy and fusion of villi, decreased villi height and crypth depth, and reduced number of goblet cells and lymphocytes. The liver, mesenteric lymph nodes and spleen of animals exposed to contaminanted diets showed a significant increase of lesions. A significant increase in caspase-3 expression in lymph nodes and spleen was observed in animals receiving the contaminated diets. In the second experiment, 12 4 to 5-week-old piglets were euthanized to obtain jejunal explants, which were exposed to 5 treatments for 4 hours, under constant stiring at 37ºC and 5% CO2 humidified atmosphere. In the control treatment were used the William’s medium E without or with the diluent DMSO to 0.1%. In the other treatments the explants were exposed to DON, NIV (1, 3, 10 µM) and fusarenone X (FX) (0.3, 1 and 3 µM). After incubation, the tissue samples were histologically processed and analyzed using histological score. The analyse of samples non-incubated and incubated with culture medium in the absence or presence of DMSO showed no significant different of histopathological score. The main lesions observed in the explants exposed to mycotoxins were villi atrophy, cuboidal and squamous epithelial cells, areas of oedema in the lamina propria and apical denudation with loss of enterocytes. The individual treatment with DON, NIV and FX resulted in a significant decrease of the histopathologic score from doses of 3µM, 1µM and 0.3 µM, respectively. In conclusion, the data obtained provide a better understanding of the possible effects of Fusarium toxins, alone or in combination on the morphology of the intestine and lymphoid organs, which would may predispose animals to secondary infections.
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Ryan, de Medeiros Anna Katharina [Verfasser], and Katja Elisabeth [Akademischer Betreuer] Odening. "In vivo und ex vivo Charakterisierung des arrhythmogenen Phänotyps transgener SQT1 Kaninchen = In vivo and ex vivo characterization of the arrhythmic phenotype of transgenic SQT1 rabbits." Freiburg : Universität, 2018. http://d-nb.info/1150643420/34.

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Müller, Robert [Verfasser]. "Radikalbildung in vivo /ex vivo nach Bestrahlung verschiedener Wellenlängen / Robert Müller." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1228859744/34.

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Barbosa, De Brito Marina de Lurdes. "Cellular integration of the dopamine signal ex vivo and in vivo." Paris 6, 2011. http://www.theses.fr/2011PA066695.

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La dopamine est un neuromodulateur impliqué dans une grande diversité de fonctions physiologiques et il est étonnant de constater qu'un faible nombre de neurones dopaminergiques puisse encoder une telle richesse d'informations. Ceci s'explique par l'organisation anatomique complexe des projections dopaminergiques, l'encodage temporel de la libération de dopamine et la diversité des récepteurs. La contribution de l'intégration post-synaptique du signal dopaminergique est mal connue. Les récepteurs D1 activent la cascade AMPc/PKA qui, jusqu'à présent, ne pouvait être étudiée qu'en dehors de son contexte spatio-temporel. Les biosenseurs FRET permettent désormais d'accéder à ces dimensions et nous avons utilisé l'imagerie optique pour suivre cette cascade de signalisation dans des neurones. Dans des tranches de cerveau, nous montrons que, par-rapport aux neurones pyramidaux du cortex, les neurones du striatum présentent une activité AC plus forte, pas d'activité PDE4 et une régulation par la DARPP-32. Ces particularités permettent aux neurones striataux de répondre efficacement à des stimulations dopaminergiques de moins d'une seconde, telles celles associées à la récompense. Ces résultats démontrent que deux types de neurones peuvent intégrer différemment un même signal dopaminergique via la même cascade de signalisation, démontrant l'importance du niveau post-synaptique dans l'intégration de l'information véhiculée par la dopamine. Pour analyser l'intégration du signal dopaminergique in vivo, nous avons utilisé la microscopie par fibre optique avec la détection simultanée de fluorescence dans deux longueurs d'onde. Nous avons mis au point et validé un nouveau biosenseur avec GFP/dTomato. Ce biosenseur et l'imagerie par fibre optique nous ont permis de suivre par imagerie in vivo, pour la première fois, l'activation de la PKA dans des neurones de régions profondes du cerveau
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Shim, Martin George Nielson. "Analysis of biological tissue with ex vivo and in vivo Raman spectroscopy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ28780.pdf.

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Steffen, Thomas. "Three-dimensional spine biomechanics, a combined in-vivo and ex-vivo approach." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0023/NQ50301.pdf.

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Steffen, Thomas 1958. "Three-dimensional spine biomechanics : a combined in-vivo and ex-vivo approach." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35502.

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Ingram, Rachel. "Mechanisms and treatments for neuropathic pain : in vivo and ex vivo investigations." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440475.

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Gómez, Segura Lídia. "Estudi farmacològic del Carprofen ex vivo i in vivo en l’espècie porcina." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673755.

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El Carprofè s’utilitza com a agent antiinflamatori, analgèsic i antipirètic. Pertany a la família de medicaments antiinflamatoris no esteroideus. S’utilitza en medicina veterinària en nombroses espècies, tot i així està molt poc estudiat el seu ús en l’espècie porcina. D’altra banda, alguns efectes indesitjables s’associen a la seva administració sistèmica. Les rutes locals alternatives són especialment útils per facilitar la seva administració en animals. La hipòtesis d’aquest treball és trobar noves formes de dosificació del Carprofè per diverses vies en l’espècie porcina. Per això, ens plantegem diversos objectius: hem volgut conèixer la capacitat de permeació del Carprofè a través d’estudis ex vivo vehiculitzat en nanopartícules o en solució en mucoses i teixits oculars per aconseguir conèixer la seva possible eficàcia, tolerància i seguretat per aquestes vies i oferir alternatives terapèutiques. D’altra banda, volem conèixer el comportament farmacocinètic del Carprofè en l’espècie porcina i així, poder avaluar tots el paràmetres per la via intravenosa i intramuscular. Finalment, ens proposem validar diferents mètodes d’anàlisis per donar fiabilitat als resultats obtinguts. En aquesta tesis hem realitzat tres treballs per donar resposta als notres objectius: 1. L’objectiu principal del primer article és validar la idoneïtat dels experiments de permeació ex vivo de Carprofè en membranes mucoses porcines (bucals, sublinguals i vaginals) i teixits oftàlmics (còrnia, esclera i conjuntiva) destinats a ser representatius de condicions in vivo. Els resultats es poden consultar en el següent article publicat: - Gómez-Segura, L.; Parra, A.; Calpena, A.C.; Gimeno, Á.; Boix-Montañes, A. Carprofen Permeation Test through Porcine Ex Vivo Mucous Membranes and Ophthalmic Tissues for Tolerability Assessments: Validation and Histological Study. Veterinary Sciences. 2020, 7, 152. 2. L’objectiu principal del segon treball és la investigació de la permeació ex vivo de Carprofè mitjançant cèl·lues de Franz a través de diferents tipus de membranes mucoses porcines i teixits oftàlmics (prèviament esmentats) per comparar la formulació de nanopartícules de Carprofè i Carprofè en solució. A més, es van realitzar estudis in vivo per verificar que les formulacions no afectaven l’estructura cel·lular i establir la quantitat retinguda als teixits. Els resultats es poden consultar en el següent article publicat: - Gómez-Segura, L.; Parra, A.; Calpena-Campmany, A.C.; Gimeno, Á.; Gómez de Aranda, I.; Boix-Montañes, A. Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues. Nanomaterials. 2020, 10, 355. 3. El tercer treball es base en l’objectiu de proporcionar un estudi per primera vegada de la farmacocinètica del Carprofè en porcs Yorkshire-Landrace. A més, un nou mètode d’anàlisi mitjançant cromatografia de líquids per espectrometria de masses ens ha permès calcular les concentracions plasmàtiques, avaluar els paràmetres farmacocinètics i la biodisponibilitat (també hem validat aquest nou mètode analític). Els resultats es podran consultar pròximament en el següent article pendent de ser publicat: - Gómez-Segura, L.; Parra, A.; Gimeno, Á; Calpena-Campmany, A.C.; Bellido, D.; Soriano-Ruiz J.L.; Boix-Montañes A. Application of liquid chromatography/mass spectrometry for bioanalysis of Carprofen in swine: pharmacokinetics and bioavailability. Pendent d’enviar. Com a conclusions finals s’ha demostrat la idoneïtat d’aquest test per quantificar la distribució de Carprofè amb una bona tolerabilitat histològica en els teixits porcins estudiats. Tanmateix, es va concloure que les nanopartícules de Carprofè poden ser una eina útil per al tractament tòpic de la inflamació local en medicina veterinària i humana. Per finalitzar, s’ha descrit i validat un nou mètode per caracteritzar la farmacocinètica del Carprofè en porcs i proposar un règim de dosificació en aquesta espècie.
El Carprofè utiliza como agente antiinflamatorio, analgésico y antipirético. Pertenece a la familia de medicamentos antiinflamatorios no esteroideos. Se utiliza en medicina veterinaria en numerosas especies, aún así está muy poco estudiado su uso en la especie porcina. Por otra parte, algunos efectos indeseables se asocian a su administración sistémica. Las rutas locales alternativas son especialmente útiles para facilitar su administración en animales. La hipótesis de este trabajo es encontrar nuevas formas de dosificación del Carprofè por diversas vías en la especie porcina. Por ello, nos planteamos varios objetivos: hemos querido conocer la capacidad de permeación del Carprofè a través de estudios ex vivo vehiculizado en nanopartículas o en solución en mucosas y tejidos oculares para lograr conocer su posible eficacia, tolerancia y seguridad por estas vías y ofrecer alternativas terapéuticas. Por otra parte, queremos conocer el comportamiento farmacocinético del Carprofè en la especie porcina y así, poder evaluar todos los parámetros para la vía intravenosa e intramuscular. Finalmente, nos proponemos validar diferentes métodos de análisis para dar fiabilidad a los resultados obtenidos. En esta tesis hemos realizado tres trabajos para dar respuesta a los Notro objetivos: 1. El objetivo principal del primer artículo es validar la idoneidad de los experimentos de permeación ex vivo de Carprofè en membranas mucosas porcinas (bucales, sublinguales y vaginales) y tejidos oftálmicos (córnea, esclera y conjuntiva) destinados a ser representativos de condiciones in vivo . Los resultados se pueden consultar en el siguiente artículo publicado: - Gómez-Segura, L .; Parra, A .; Calpena, A.C .; Gimeno, Á .; Boix-Montañes, A. Carprofen Permeation Test through Porcine Ex Vivo Mucous Membranas and Ophthalmic Tissues for Tolerability Assessments: Validation and Histological Study. Veterinary Sciences. 2020, 7, 152. 2. El objetivo principal del segundo trabajo es la investigación de la permeación ex vivo de Carprofè mediante Cellu de Franz a través de diferentes tipos de membranas mucosas porcinas y tejidos oftálmicos previamente mencionados para comparar la formulación de nanopartículas de Carprofè y Carprofè en solución. Además, se realizaron estudios in vivo para verificar que las formulaciones no afectaban la estructura celular y establecer la cantidad retenida a los tejidos. Los resultados se pueden consultar en el siguiente artículo publicado: - Gómez-Segura, L .; Parra, A .; Calpena-Campmany, A.C .; Gimeno, Á .; Gómez de Aranda, Y .; Boix-Montañes, A. Ex Vivo Permeation of Carprofen Vehiculated by PLGA nanoparticles through Porcine Mucous Membranas and Ophthalmic Tissues. Nanomateriales. 2020, 10, 355. 3. El tercer trabajo se base en el objetivo de proporcionar un estudio por primera vez de la farmacocinética del Carprofè en cerdos Yorkshire-Landrace. Además, un nuevo método de análisis mediante cromatografía de líquidos por espectrometría de masas nos ha permitido calcular las concentraciones plasmáticas, evaluar los parámetros farmacocinéticos y la biodisponibilidad (también hemos validado este nuevo método analítico). Los resultados se podrán consultar próximamente en el siguiente artículo pendiente de ser publicado: - Gómez-Segura, L .; Parra, A .; Gimeno, Á; Calpena-Campmany, A.C .; Bellido, D .; Soriano-Ruiz J.L .; Boix-Montañes A. Application of liquid chromatography / mass spectrometry for Bioanalysis of Carprofen in swine: pharmacokinetics and Bioavailability. Pendiente de enviar. Como conclusiones finales se ha demostrado la idoneidad de este test para cuantificar la distribución de Carprofè con una buena tolerabilidad histológica en los tejidos porcinos estudiados. Sin embargo, se concluyó que las nanopartículas de Carprofè pueden ser una herramienta útil para el tratamiento tópico de la inflamación local en medicina veterinaria y humana. Para finalizar, se ha descrito y validado un nuevo método para caracterizar la farmacocinética del Carprofè en cerdos y proponer un régimen de dosificación en esta especie.
Carprofen is used as an anti-inflammatory, analgesic and antipyretic agent. It belongs to the family of non-steroidal anti-inflammatory drugs. It is used in veterinary medicine in many species, although its use in the porcine species is very little studied. On the other hand, some side effects are associated with its systemic administration. Alternative local routes are especially useful for ease of administration in animals. The hypothesis of this work is to find new ways of dosing Carprofen in various ways in porcine species. Therefore, we set ourselves several objectives: we wanted to know the permeation capacity of Carprofen through ex vivo studies carried in nanoparticles or in solution in mucous membranes and eye tissues to get to know its possible efficacy, tolerance and safety by these routes offer therapeutic alternatives. On the other hand, we want to know the pharmacokinetic behavior of Carprofen in the porcine species and thus be able to evaluate all the parameters intravenously and intramuscularly. Finally, we propose to validate different methods of analysis to give reliability to the results obtained. In this thesis we have carried out three works to respond to our objectives: 1. The main objective of the first article is to validate the suitability of ex vivo permeation experiments of Carprofen in porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) intended to be representative of in vivo conditions. . The results can be consulted in the following published article: - Gómez-Segura, L .; Parra, A .; Calpena, A.C .; Gimeno, Á .; Boix-Montañes, A. Carprofen Permeation Test through Porcine Ex Vivo Mucous Membranes and Ophthalmic Tissues for Tolerability Assessments: Validation and Histological Study. Veterinary Sciences. 2020, 7, 152. 2. The main objective of the second work is the investigation of the ex vivo permeation of Carprofen by Franz cells through different types of porcine mucous membranes and ophthalmic tissues previously mentioned to compare the formulation of nanoparticles of Carprofen and Carprofen in solution. In addition, in vivo studies were performed to verify that the formulations did not affect cell structure and to establish the amount retained in tissues. The results can be consulted in the following published article: - Gómez-Segura, L .; Parra, A .; Calpena-Campmany, A.C .; Gimeno, Á .; Gómez de Aranda, I .; Boix-Montañes, A. Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues. Nanomaterials. 2020, 10, 355. 3. The third work is based on the aim of providing a first study of the pharmacokinetics of Carprofen in Yorkshire-Landrace pigs. In addition, a new method of analysis by liquid chromatography by mass spectrometry has allowed us to calculate plasma concentrations, evaluate pharmacokinetic parameters and bioavailability (we have also validated this new analytical method). The results will be available soon in the following article pending publication: - Gómez-Segura, L .; Parra, A .; Gimeno, Á; Calpena-Campmany, A.C .; Bellido, D .; Soriano-Ruiz J.L .; Boix-Montañes A. Application of liquid chromatography / mass spectrometry for bioanalysis of Carprofen in swine: pharmacokinetics and bioavailability. Pending submission. Final conclusions have been shown to be suitable for this test to quantify the distribution of Carprofen with good histological tolerability in swines tissues studied. However, it was concluded that Carprofen nanoparticles may be a useful tool for the topical treatment of local inflammation in veterinary and human medicine. Finally, a new method has been described and validated to characterize the pharmacokinetics of Carprofen in swines and to propose a dosing regimen in this species.
Universitat Autònoma de Barcelona. Programa de Doctorat en Medicina i Sanitat Animals
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Blenkiron, Marc. "Reprogrammable in vivo architecture." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29220.

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So far, the large majority of in vivo computation research has been based on the detection and conditional manipulation of protein concentrations inside cells, which is the biological method of gene expression. In contrast, this thesis describes how a computational program, encoded in genetic material inside a bacterium, can be triggered by external stimuli to reassemble itself in a directed manner to create a newly arranged computational program. In order to investigate the potential utility of in vivo self-arranging programs, software was designed to explore a search space of candidate computational programs, encoded in genetic material, which are able to rearrange themselves; to simulate these candidates and to evaluate their behaviour against a set of criteria. Rearrangements were facilitated by biological catalysts which can selectively sever and rejoin genetic material in a cooperative manner. Their ability to perform compound operations was found to allow for a general purpose mechanism. As proof of concept, one of the candidate computational programs, a two-colour switch which can be set irreversibly through its rearrangement, was encoded in genetic material. Measurements of in vivo expression were observed resulting from in vitro rearrangement manipulations, to illustrate its operation.
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Books on the topic "In vivo"

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Vive tu vida al rojo vivo. New York: Atria Books, 2009.

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Börner, Katy, Michael Conlon, Jon Corson-Rikert, and Ying Ding. VIVO. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-79435-3.

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Peregrín, Josefina Martos. Mortalmente vivo. Granada: Ediciones Dauro, 2014.

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Radius, Emilio. Verdi vivo. Milano: Baldini & Castoldi, 2001.

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1926-, Ronfani Ugo, ed. Goldoni vivo. Roma: Presidenza del consiglio dei ministri, Dipartimento per l'informazione e l'editoria, 1994.

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Heredia, Eugenio Moreno. Presente vivo. Cuenca, Ecuador: Departamento de Difusión Cultural de la Universidad de Cuenca, 1989.

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Barrios, Jesús Enrique. Mientras vivo. Barquisimeto, Lara, Venezuela: Ediciones de Rectorado de la Universidad Centroccidental "Lisandro Alvarado", 2006.

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Lavoro vivo. Roma: Alegre, 2012.

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In vivo. Beograd: Narodna knjiga-Alfa, 2007.

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Arnoldo, Mosca Mondadori, ed. Eternamente vivo. 2nd ed. [Milan, Italy]: Frassinelli, 2010.

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Book chapters on the topic "In vivo"

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Tomich, Liz, and Alex Viggio. "Case Study: University of Colorado Boulder." In VIVO, 53–64. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-79435-3_4.

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Albert, Paul J., Curtis Cole, Dan Dickinson, John Ruffing, Markus Bronniman, Eliza Chan, and Kenneth Lee. "Case Study: Weill Cornell Medical College." In VIVO, 65–83. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-79435-3_5.

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Conlon, Michael. "Scholarly Networking Needs and Desires." In VIVO, 1–13. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-79435-3_1.

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Barnes, Chris, Stephen Williams, Vincent Sposato, Nicholas Skaggs, Narayan Raum, Jon Corson-Rikert, Brian Caruso, and Jim Blake. "Extending VIVO." In VIVO, 85–103. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-79435-3_6.

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Davis, Valrie, Kristi L. Holmes, Brian J. Lowe, Leslie McIntosh, Liz Tomich, and Alex Viggio. "Implementing VIVO and Filling It with Life." In VIVO, 35–52. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-79435-3_3.

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Krafft, Dean B., Katy Börner, Jon Corson-Rikert, and Kristi L. Holmes. "The Future of VIVO: Growing the Community." In VIVO, 129–41. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-79435-3_8.

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Heppner, John B., D. G. Boucias, J. C. Pendland, Andrei Sourakov, Timothy Ebert, Roger Downer, Kun Yan Zhu, et al. "In Vivo." In Encyclopedia of Entomology, 2044. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_1582.

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Adler, I.-D. "Mutagenitätstestsin vivo." In Toxikologie, 343–56. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527604820.ch21.

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Carroll, Marilyn E., Peter A. Santi, Joseph Zohar, Thomas R. E. Barnes, Peter Verheart, Per Svenningsson, Per E. Andrén, et al. "In vivo." In Encyclopedia of Psychopharmacology, 628. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_928.

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Batley-Matias, Pili, and Brian Hill. "Vivo en …" In Breakthrough Video Spanish, 64–69. London: Macmillan Education UK, 1989. http://dx.doi.org/10.1007/978-1-349-80683-6_14.

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Conference papers on the topic "In vivo"

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Han, Bo, Yu Liu, and Feng Qian. "ViVo." In MobiCom '20: The 26th Annual International Conference on Mobile Computing and Networking. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3372224.3380888.

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Zhu, Yeshuang, Yuntao Wang, Chun Yu, Shaoyun Shi, Yankai Zhang, Shuang He, Peijun Zhao, Xiaojuan Ma, and Yuanchun Shi. "ViVo." In CHI '17: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3025453.3025779.

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Oraevsky, Alexander, Elena V. Savateeva, Alexander A. Karabutov, Brent Bell, Richard Johnigan, Jay P. Pasricha, and Massoud Motamedi. "Application of the confocal opto-acoustic tomography in detection of squamous epithelial carcinoma at early stages." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.dis153.

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Confocal opto-acoustic transducer (COAT) was developed and applied for detection of early stages of squamous cell carcinoma in hamster model of oral cancer. COAT is a novel imaging modality capable of detecting profiles of wide-band ultrasonic transients at the site of pulsed laser irradiation. Animal model of oral cancer used Syrian golden hamsters treated with carcinogenic agent, DMBA (9,10-Dimethyl-1,2-Benzanthracene). Opto-acoustic tomography was applied to visualize the course of cancer development from normal to displasia, to carcinoma in situ, to invasive carcinoma. Correlation of the opto-acoustic images with H&E histology sections confirmed that early cancer lesions, invisible by gross observation, could be detected with the opto-acoustic tomography. Our hypothesis is that pronounced contrast revealed by the opto-acoustic tomography between normal and malignant tissues is associated with increased sizes and concentration of cellular nuclei at the stage of microscopic displasia and with tumor angiogenesis at the later stages. Characteristic feature of carcinoma progression as demonstrated by COAT is the gradual loss of layered structure in mucous and developing heterogeneity.
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George, John S., David M. Rector, Cheng Ho, Kevin Albright, Clayton Smith, and Andreas H. Hielscher. "Time Resolved Photon Migration Tomography with a Novel Remote Ultra Low Light Imager (RULLI)." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.dis177.

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We describe the design and initial applications of an instrument for time and spatially resolved photon migration tomography. The remote ultra low light imager (RULLI) records photon X, and Y positions, and time with <20 ps resolution. Placing the RULLI detector on one side of a scattering object, and illuminating the other side, measures the time history, amplitude, and positions of photons traveling through the object. Another configuration uses a fiber optic collecting array with elements placed at many locations surrounding the object. Spatial and temporal patterns of photon arrival are recorded from multiple source locations around the object, allowing reconstruction of optical properties of the medium.
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Liu, Hanli, Cole A. Giller, and Maureen Johns. "Brain Structural Mapping during Stereotactic Surgery for Movement Disorders Using Optical Reflectance Spectroscopy." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.dis100.

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Precise localization of anatomic structures within the brain is crucial to neurosurgeons. In this paper, we report our recent investigation of using a low-cost, miniaturized, optical reflectance (elastic) spectroscopy device to obtain, in real-time, brain structural mapping during stereotactic surgery for movement disorders. 20 subjects were studied with IRB approval during temporal lobectomy or stereotactic surgery. The Measurement results show that this instrument along with our developed algorithm allows us to distinguish white and gray matter with a resolution of 1 mm. The technique is extremely easy in practice, and the equipment is inexpensive, miniature, and provides real-time brain structural mapping and localization in the operating room.
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Pogue, Brian W., Troy O. McBride, Steven P. Poplack, Ulf L. Osterberg, and Keith D. Paulsen. "Imaging hemoglobin concentration and oxygen saturation in the female breast with near-infrared diffusion tomography." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.dis124.

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Measurements of diffuse near-infrared light are used to tomographically image hemoglobin in tissue. A diffusion theory finite element solution is matches theoretical predictions to these measurements, allowing computed images of absorption and scattering coefficients to be recovered from the projection data by iteratively solving a regularized matrix equation which using the Newton-Raphson method. The diffuse measurements are recorded at wavelengths between 660 nm and 850 nm with automated data acqusition, using intensity-modulated light at 100 MHz. This prototype system is being tested on breast cancer patients to determine the utility of hemoglobin morphology for tumor diagnosis. Hemoglobin concentration and oxygen saturation images are derived from reconstructed absorption coefficient images at multiple wavelengths through a multi-parameter concentration fit at each point in the image. The chromophores assumed to be present in breast tissue are water, lipids, oxy- and deoxy-hemoglobin. This type of data acquisition system allows multi-spectral imaging which may provide the information needed to accurately recover the hemoglobin concentration and oxygen saturation images of the breast.
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Boppart, Stephen A., Wolfgang Drexler, Uwe Morgner, Franz X. Kärtner, and James G. Fujimoto. "Ultrahigh Resolution and Spectroscopic OCT Imaging of Cellular Morphology and Function." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.msi56.

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Optical coherence tomography (OCT) is a promising optical microscopy technique which enables ultrahigh-resolution, spectroscopic, in vivo imaging in transparent and non-transparent biological specimens. This is achieved by exploiting the short temporal coherence of ultrabroad bandwidth light sources to image morphological features at subcellular resolution at depths beyond that of conventional bright-field and confocal microscopes. Extraction of spatially resolved spectroscopic information is feasible to improve image contrast and to obtain functional or biochemical properties of the investigated tissue. The potential for using OCT to image the morphological expression of genes involved in normal and abnormal development has been shown in common developmental biology animal models. In vivo imaging of single cell morphology, mitosis, and migration, as well as preliminary spectroscopic imaging, is demonstrated.
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Wilson, T., and D. Karadaglić. "Image formation in conventional fluorescence optical microscopes with structured illumination." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.msi7.

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We present a theoretical analysis of the image formation in conventional fluorescence microscopes with structured illumination. We show that optically sectioned images may be obtained with sectioning strengths comparable to those obtained in the confocal microscope. We further show that the approach leads to images exhibiting enhanced spatial frequency content and transfer function behaviour directly comparable to that of the true confocal instrument.
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Webb, Watt W. "Multiphoton Microscopy MPM: Imaging Spectra and Dynamics of Molecular Function Deep in Living Tissues." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.msi3.

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Multiphoton Excitation (MPE) of fluorescence provides the optimum photophysics for microscopic imaging deep in living tissue with minimal photodamage, to depths so far ~ 400 µm. Tissue autofluorescence excited by two-photon or three-photon absorption to ultra-violet energies can provide specific indications of disease. Useful autofluorescence of serotonin (5HT), melatonin, indolamine breakdown products, NADH, collagen, elastin, and a number of yet-to-be-identified molecular species, some of which identify disease states are already being imaged routinely. For research in model animals, genetic constructs that label specific molecules with mutants of Green Fluorescent Protein (GFP) can be imaged deep in tissue with MPM. MPM excitation of GFP mutants at nanomolar concentrations for Fluorescence Correlation Spectroscopy (FCS) provides a robust, internally calibrated, new measure of pH in cells and tissues. Fluorescent labels that penetrate tissue can be usefully imaged in living animals and thick tissue cultures; for example, thioflavins in the beta amyloid plaques of Alzheimer’s Disease are being imaged deep in living transgenic mouse brains. Multiphoton imaging spectroscopy and fluorescence lifetime imaging (FLIM) provides useful molecular identification diagnostics. Some applications are shown in order to illustrate capability. However, the potential of MPM for in vivoimaging has barely been explored, and this technology should be regarded as providing a fertile opportunity that is yet to be fully exploited for biomedical research and for clinical applications.
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Faris, Gregory W., Martina Gerken, Mark J. Dyer, and Xingkun Wu. "Optical Matching Techniques and Molecular Upconverting Reporters." In In Vivo optical Imaging at the NIH. Washington, D.C.: Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.dis172.

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We are applying optical matching techniques to two types of applications: (1) the accurate determination of tissue optical properties and (2) improving in vivo imaging quality. With optical matching, measurement of tissue optical properties to accuracies of a few percent is possible. Accurate tissue properties are useful for physiological monitoring, modeling optical imaging and therapies, and providing a priori information for image reconstruction. For imaging, matching improves illumination uniformity and contrast, and makes better use of image dynamic range. In a separate effort, we are developing a new class of reporters which provide upconversion from molecular labels. Advantages of these materials include no autofluorescence, multiplexing capabilities, no photobleaching, and excitation with compact and low power diode lasers. Applications include in vitro assays and in vivo imaging.
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Reports on the topic "In vivo"

1

Navarrete, Jesús, Rodrigo Caimanque, Luis Sáenz, Isidora Larrain de Andraca, and Clara Irazábal. Patrimonio vivo: Guía metodológica. Inter-American Development Bank, December 2020. http://dx.doi.org/10.18235/0002908.

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La implementación del Programa Patrimonio Vivo en las ciudades y centros históricos de la región implica desafíos multidimensionales al buscar la integración de componentes de gobernanza, resiliencia, inclusión social y productividad, entre otras, a la revitalización patrimonial urbana. El desarrollo de herramientas y métodos de acción adecuados resultan clave para una ejecución acorde a los desafíos de las áreas patrimoniales. El presente documento corresponde a una guía práctica que define los pasos necesarios para implementar la metodología Patrimonio Vivo. En esta, se definen actores y sus roles, tiempos y mecanismos asociados al logro de hitos del programa, y una ruta hacia la consolidación del Plan Estratégico y el Esquema de Financiamiento. Estos últimos son los principales instrumentos que Patrimonio Vivo dejará instalados en la ciudad para iniciar el proceso de revitalización patrimonial.
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Navarrete, Jesús, Rodrigo Caimanque, Luis Sáenz, Isidora Larrain de Andraca, and Clara Irazábal. Patrimonio vivo: Guía metodológica. Inter-American Development Bank, December 2020. http://dx.doi.org/10.18235/0002908.

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Abstract:
La implementación del Programa Patrimonio Vivo en las ciudades y centros históricos de la región implica desafíos multidimensionales al buscar la integración de componentes de gobernanza, resiliencia, inclusión social y productividad, entre otras, a la revitalización patrimonial urbana. El desarrollo de herramientas y métodos de acción adecuados resultan clave para una ejecución acorde a los desafíos de las áreas patrimoniales. El presente documento corresponde a una guía práctica que define los pasos necesarios para implementar la metodología Patrimonio Vivo. En esta, se definen actores y sus roles, tiempos y mecanismos asociados al logro de hitos del programa, y una ruta hacia la consolidación del Plan Estratégico y el Esquema de Financiamiento. Estos últimos son los principales instrumentos que Patrimonio Vivo dejará instalados en la ciudad para iniciar el proceso de revitalización patrimonial.
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Navarrete, Jesús, Rodrigo Caimanque, Luis Sáenz, Isidora Larrain de Andraca, and Clara Irazábal. Patrimonio vivo: Documento de enfoque. Inter-American Development Bank, December 2020. http://dx.doi.org/10.18235/0002909.

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América Latina y El Caribe poseen un rico patrimonio expresado en sus edificaciones históricas, paisajes naturales, así como en sus valiosas expresiones culturales. Sin embargo, el patrimonio de la región también posee marcadas muestras de deterioro y subutilización, afectando la calidad de vida de sus comunidades locales, perdiéndose una oportunidad de aprovechamiento del potencial social y económico que ofrece. El presente documento entrega las bases conceptuales del programa de revitalización patrimonial, Patrimonio Vivo, enfocado en abordar las problemáticas urbanas patrimoniales de las ciudades del ALC desde un enfoque integral, inclusivo y sostenible. El documento incorpora las bases conceptuales y objetivos del programa, desarrollados a partir de cinco pilares que lo componen: inclusión, productividad, ecoeficiencia, resiliencia y colaboración.
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Navarrete, Jesús, Rodrigo Caimanque, Luis Sáenz, Isidora Larrain de Andraca, and Clara Irazábal. Patrimonio vivo: Documento de enfoque. Inter-American Development Bank, December 2020. http://dx.doi.org/10.18235/0002909.

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Abstract:
América Latina y El Caribe poseen un rico patrimonio expresado en sus edificaciones históricas, paisajes naturales, así como en sus valiosas expresiones culturales. Sin embargo, el patrimonio de la región también posee marcadas muestras de deterioro y subutilización, afectando la calidad de vida de sus comunidades locales, perdiéndose una oportunidad de aprovechamiento del potencial social y económico que ofrece. El presente documento entrega las bases conceptuales del programa de revitalización patrimonial, Patrimonio Vivo, enfocado en abordar las problemáticas urbanas patrimoniales de las ciudades del ALC desde un enfoque integral, inclusivo y sostenible. El documento incorpora las bases conceptuales y objetivos del programa, desarrollados a partir de cinco pilares que lo componen: inclusión, productividad, ecoeficiencia, resiliencia y colaboración.
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Kruchten, D. A., and D. P. Hickman. Absolute calibration in vivo measurement systems. Office of Scientific and Technical Information (OSTI), February 1991. http://dx.doi.org/10.2172/6063303.

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Guelta, Mark A., Steven P. Harvey, and Melissa M. Dixon. Ex Vivo Measurement of Enzyme Stability in Human Plasma: A Potential Screening Method for In Vivo Stability. Fort Belvoir, VA: Defense Technical Information Center, May 2014. http://dx.doi.org/10.21236/ada601155.

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Synold, Timothy W. In Vivo Imaging of MDR1A Gene Expression. Fort Belvoir, VA: Defense Technical Information Center, December 2004. http://dx.doi.org/10.21236/ada433034.

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Nepom, Gerald T. Humanized in vivo Model for Autoimmune Diabetes. Fort Belvoir, VA: Defense Technical Information Center, February 2010. http://dx.doi.org/10.21236/ada523882.

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Nepom, Gerald T., and John A. Gebe. Humanized in vivo Model for Autoimmune Diabetes. Fort Belvoir, VA: Defense Technical Information Center, February 2009. http://dx.doi.org/10.21236/ada625335.

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Nepom, Gerald T., and John A. Gebe. Humanized in vivo Model for Autoimmune Diabetes. Fort Belvoir, VA: Defense Technical Information Center, February 2008. http://dx.doi.org/10.21236/ada482199.

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