Relevant bibliographies by topics / IMRT

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Academic literature on the topic 'IMRT'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 June 2025

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Journal articles on the topic "IMRT"

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Youssef, Irini, Jennifer Yoon, Nader Mohamed, Kaveh Zakeri, Robert H. Press, Linda Chen, Daphna Y. Gelblum, et al. "Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Oropharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy." JAMA Network Open 5, no. 11 (November 11, 2022): e2241538. http://dx.doi.org/10.1001/jamanetworkopen.2022.41538.

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ImportancePatients with oropharyngeal carcinoma (OPC) treated with radiotherapy often experience substantial toxic effects, even with modern techniques such as intensity-modulated radiation therapy (IMRT). Intensity-modulated proton therapy (IMPT) has a potential advantage over IMRT due to reduced dose to the surrounding organs at risk; however, data are scarce given the limited availability and use of IMPT.ObjectiveTo compare toxic effects and oncologic outcomes among patients with newly diagnosed nonmetastatic OPC treated with IMPT vs IMRT with or without chemotherapy.Design, Setting, and ParticipantsThis retrospective cohort study included patients aged 18 years or older with newly diagnosed nonmetastatic OPC who received curative-intent radiotherapy with IMPT or IMRT at a single-institution tertiary academic cancer center from January 1, 2018, to December 31, 2021, with follow-up through December 31, 2021.ExposuresIMPT or IMRT with or without chemotherapy.Main Outcomes and MeasuresThe main outcomes were the incidence of acute and chronic (present after ≥6 months) treatment-related adverse events (AEs) and oncologic outcomes, including locoregional recurrence (LRR), progression-free survival (PFS), and overall survival (OS). Fisher exact tests and χ2 tests were used to evaluate associations between toxic effects and treatment modality (IMPT vs IMRT), and the Kaplan-Meier method was used to compare LRR, PFS, and OS between the 2 groups.ResultsThe study included 292 patients with OPC (272 [93%] with human papillomavirus [HPV]-p16–positive tumors); 254 (87%) were men, 38 (13%) were women, and the median age was 64 years (IQR, 58-71 years). Fifty-eight patients (20%) were treated with IMPT, and 234 (80%) were treated with IMRT. Median follow-up was 26 months (IQR, 17-36 months). Most patients (283 [97%]) received a dose to the primary tumor of 70 Gy. Fifty-seven of the patients treated with IMPT (98%) and 215 of those treated with IMRT (92%) had HPV-p16–positive disease. There were no significant differences in 3-year OS (97% IMPT vs 91% IMRT; P = .18), PFS (82% IMPT vs 85% IMRT; P = .62), or LRR (5% IMPT vs 4% IMRT; P = .59). The incidence of acute toxic effects was significantly higher for IMRT compared with IMPT for oral pain of grade 2 or greater (42 [72%] IMPT vs 217 [93%] IMRT; P < .001), xerostomia of grade 2 or greater (12 [21%] IMPT vs 68 [29%] IMRT; P < .001), dysgeusia of grade 2 or greater (16 [28%] IMPT vs 134 [57%] IMRT; P < .001), grade 3 dysphagia (4 [7%] IMPT vs 29 [12%] IMRT; P < .001), mucositis of grade 3 or greater (10 [53%] IMPT vs 13 [70%] IMRT; P = .003), nausea of grade 2 or greater (0 [0%] IMPT vs 18 [8%] IMRT; P = .04), and weight loss of grade 2 or greater (22 [37%] IMPT vs 138 [59%] IMRT; P < .001). There were no significant differences in chronic toxic effects of grade 3 or greater, although there was a significant difference for chronic xerostomia of grade 2 or greater (6 IMPT [11%] vs 22 IMRT [10%]; P < .001). Four patients receiving IMRT (2%) vs 0 receiving IMPT had a percutaneous endoscopic gastrostomy tube for longer than 6 months.Conclusions and RelevanceIn this study, curative-intent radiotherapy with IMPT for nonmetastatic OPC was associated with a significantly reduced acute toxicity burden compared with IMRT, with few chronic toxic effects and favorable oncologic outcomes, including locoregional recurrence of only 5% at 2 years. Prospective randomized clinical trials comparing these 2 technologies and of patient-reported outcomes are warranted.
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Thaker, Nikhil G., David Boyce-Fappiano, Matthew S. Ning, Dario Pasalic, Alexis Guzman, Grace Smith, Emma B. Holliday, et al. "Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer." International Journal of Particle Therapy 8, no. 1 (June 1, 2021): 374–82. http://dx.doi.org/10.14338/ijpt-20-00042.1.

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Abstract Purpose In value-based health care delivery, radiation oncologists need to compare empiric costs of care delivery with advanced technologies, such as intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT). We used time-driven activity-based costing (TDABC) to compare the costs of delivering IMPT and IMRT in a case-matched pilot study of patients with newly diagnosed oropharyngeal (OPC) cancer. Materials and Methods We used clinicopathologic factors to match 25 patients with OPC who received IMPT in 2011-12 with 25 patients with OPC treated with IMRT in 2000-09. Process maps were created for each multidisciplinary clinical activity (including chemotherapy and ancillary services) from initial consultation through 1 month of follow-up. Resource costs and times were determined for each activity. Each patient-specific activity was linked with a process map and TDABC over the full cycle of care. All calculated costs were normalized to the lowest-cost IMRT patient. Results TDABC costs for IMRT were 1.00 to 3.33 times that of the lowest-cost IMRT patient (mean ± SD: 1.65 ± 0.56), while costs for IMPT were 1.88 to 4.32 times that of the lowest-cost IMRT patient (2.58 ± 0.39) (P < .05). Although single-fraction costs were 2.79 times higher for IMPT than for IMRT (owing to higher equipment costs), average full cycle cost of IMPT was 1.53 times higher than IMRT, suggesting that the initial cost increase is partly mitigated by reductions in costs for other, non-RT supportive health care services. Conclusions In this matched sample, although IMPT was on average more costly than IMRT primarily owing to higher equipment costs, a subset of IMRT patients had similar costs to IMPT patients, owing to greater use of supportive care resources. Multidimensional patient outcomes and TDABC provide vital methodology for defining the value of radiation therapy modalities.
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Yoon, Han Gyul, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, and Seyjoon Park. "Early Clinical Outcomes of Intensity Modulated Radiation Therapy/Intensity Modulated Proton Therapy Combination in Comparison with Intensity Modulated Radiation Therapy Alone in Oropharynx Cancer Patients." Cancers 13, no. 7 (March 27, 2021): 1549. http://dx.doi.org/10.3390/cancers13071549.

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Purpose: To report the early clinical outcomes of combining intensity-modulated radiation therapy (IMRT) and intensity-modulated proton therapy (IMPT) in comparison with IMRT alone in treating oropharynx cancer (OPC) patients. Materials and Methods: The medical records of 148 OPC patients who underwent definitive radiotherapy (RT) with concurrent systemic therapy, from January 2016 till December 2019 at Samsung Medical Center, were retrospectively reviewed. During the 5.5 weeks’ RT course, the initial 16 (or 18) fractions were delivered by IMRT in all patients, and the subsequent 12 (or 10) fractions were either by IMRT in 81 patients (IMRT only) or by IMPT in 67 (IMRT/IMPT combination), respectively, based on comparison of adaptive re-plan profiles and availability of equipment. Propensity-score matching (PSM) was done on 76 patients (38 from each group) for comparative analyses. Results: With the median follow-up of 24.7 months, there was no significant difference in overall survival and progression free survival between groups, both before and after PSM. Before PSM, the IMRT/IMPT combination group experienced grade ≥ 3 acute toxicities less frequently: mucositis in 37.0% and 13.4% (p < 0.001); and analgesic quantification algorithm (AQA) in 37.0% and 19.4% (p = 0.019), respectively. The same trends were observed after PSM: mucositis in 39.5% and 15.8% (p = 0.021); and AQA in 47.4% and 21.1% (p = 0.016), respectively. In multivariate logistic regression, grade ≥ 3 mucositis was significantly less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.027 and 0.024, respectively). AQA score ≥ 3 was also less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.085 and 0.018, respectively). Conclusions: In treating the OPC patients, with comparable early oncologic outcomes, more favorable acute toxicity profiles were achieved following IMRT/IMPT combination than IMRT alone.
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Nenoff, Lena, Atchar Sudhyadhom, Jackson Lau, Gregory C. Sharp, Harald Paganetti, and Jennifer Pursley. "Comparing Predicted Toxicities between Hypofractionated Proton and Photon Radiotherapy of Liver Cancer Patients with Different Adaptive Schemes." Cancers 15, no. 18 (September 15, 2023): 4592. http://dx.doi.org/10.3390/cancers15184592.

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With the availability of MRI linacs, online adaptive intensity modulated radiotherapy (IMRT) has become a treatment option for liver cancer patients, often combined with hypofractionation. Intensity modulated proton therapy (IMPT) has the potential to reduce the dose to healthy tissue, but it is particularly sensitive to changes in the beam path and might therefore benefit from online adaptation. This study compares the normal tissue complication probabilities (NTCPs) for liver and duodenal toxicity for adaptive and non-adaptive IMRT and IMPT treatments of liver cancer patients. Adaptive and non-adaptive IMRT and IMPT plans were optimized to 50 Gy (RBE = 1.1 for IMPT) in five fractions for 10 liver cancer patients, using the original MRI linac images and physician-drawn structures. Three liver NTCP models were used to predict radiation-induced liver disease, an increase in albumin-bilirubin level, and a Child–Pugh score increase of more than 2. Additionally, three duodenal NTCP models were used to predict gastric bleeding, gastrointestinal (GI) toxicity with grades >3, and duodenal toxicity grades 2–4. NTCPs were calculated for adaptive and non-adaptive IMRT and IMPT treatments. In general, IMRT showed higher NTCP values than IMPT and the differences were often significant. However, the differences between adaptive and non-adaptive treatment schemes were not significant, indicating that the NTCP benefit of adaptive treatment regimens is expected to be smaller than the expected difference between IMRT and IMPT.
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Cunningham, Lisa, Scott Penfold, Eileen Giles, Hien Le, and Michala Short. "Impact of Breast Size on Dosimetric Indices in Proton Versus X-ray Radiotherapy for Breast Cancer." Journal of Personalized Medicine 11, no. 4 (April 8, 2021): 282. http://dx.doi.org/10.3390/jpm11040282.

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Deep inspiration breath hold (DIBH) radiotherapy is a technique used to manage early stage left-sided breast cancer. This study compared dosimetric indices of patient-specific X-ray versus proton therapy DIBH plans to explore differences in target coverage, radiation doses to organs at risk, and the impact of breast size. Radiotherapy plans of sixteen breast cancer patients previously treated with DIBH radiotherapy were re-planned with hybrid inverse-planned intensity modulated X-ray radiotherapy (h-IMRT) and intensity modulated proton therapy (IMPT). The total prescribed dose was 40.05 Gy in 15 fractions for all cases. Comparisons between the clinical, h-IMRT, and IMPT evaluated doses to target volumes, organs at risk, and correlations between doses and breast size. Although no differences were observed in target volume coverage between techniques, the h-IMRT and IMPT were able to produce more even dose distributions and IMPT delivered significantly less dose to all organs at risk than both X-ray techniques. A moderate negative correlation was observed between breast size and dose to the target in X-ray techniques, but not IMPT. Both h-IMRT and IMPT produced plans with more homogeneous dose distribution than forward-planned IMRT and IMPT achieved significantly lower doses to organs at risk compared to X-ray techniques.
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Gergelis, Kimberly R., Miao Bai, Jiasen Ma, David M. Routman, Bradley J. Stish, Brian J. Davis, Thomas M. Pisansky, Thomas J. Whitaker, and Richard Choo. "Long-Term Patient-Reported Bowel and Urinary Quality of Life in Patients Treated with Intensity-Modulated Radiotherapy Versus Intensity-Modulated Proton Therapy for Localized Prostate Cancer." Current Oncology 32, no. 4 (April 2, 2025): 212. https://doi.org/10.3390/curroncol32040212.

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Purpose: This study aimed to compare long-term patient-reported outcomes in bowel and urinary domains between intensity-modulated radiotherapy (IMRT) and intensity-modulated proton therapy (IMPT) for localized prostate cancer. Methods and Materials: Patients with clinical T1–T2 prostate cancer receiving IMRT or IMPT at a tertiary cancer center from 2015–2018 were analyzed to determine the changes in the prospectively collected bowel function (BF), urinary irritative/obstructive symptoms (UO), and urinary incontinence (UI) domains of EPIC-26. The mean changes in EPIC-26 scores were evaluated from pretreatment to 24 months post-radiotherapy for each modality. A score change >50% of the baseline standard deviation was considered a clinically meaningful change. Results: A total of 82 patients treated with IMRT (52.2%) and 56 patients treated with IMPT (53.3%) completed the questionnaire at baseline and 24 months post-RT. There were no baseline differences in domain scores between treatment modalities. At 24 months post-radiotherapy, there was a significant and clinically meaningful decline in the BF mean score in the IMRT cohort (−4.52 (range −50, 29.17), p = 0.003), whereas the decline in BF score did not reach clinical relevance or significance (−1.88 (range −37.5, 50), p = 0.046) when accounting for the Bonferroni adjustment in the IMPT cohort. A higher proportion of patients treated with IMRT had a clinically relevant reduction in BF when compared with IMPT (47.37% vs. 25.93%, p = 0.017). The mean changes in the UI and UO scores of the IMRT and IMPT cohorts were neither statically significant nor clinically relevant. Conclusions: IMPT leads to a smaller decrease in BF than IMRT at 24 months post-RT, while there was no differential effect on UO and UI.
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Lescut, Nicolas, Etienne Martin, Philippe Maingon, Magali Quivrin, Celine Mirjolet, Suzanne Naudy, Aurelie Petitfils, and Gilles Crehange. "Dependence of intrafraction prostate motion within the pelvis on fraction duration during whole pelvic intensity modulated arctherapy (IMAT) versus dynamic IMRT." Journal of Clinical Oncology 31, no. 6_suppl (February 20, 2013): 190. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.190.

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190 Background: To compare the 3-dimensional intra-fraction variations of prostate position within the pelvis with whole-pelvic fixed-field intensity-modulated radiation therapy (IMRT) vs. intensity-modulated arc therapy (IMAT) in high-risk prostate cancer. Methods: Fifteen PCa patients underwent whole pelvic radiotherapy using either dynamic IMRT with a sliding window technique (n= 8) or IMAT (n= 7). All the patients had a kV cone-beam computed tomography (CBCT) before and immediately after each fraction of IMRT or IMAT. Intra-fraction motions of the prostate were determined using a 2-step procedure performed on each pre- and post-treatment imaging: 1) planning CT and CBCT were matched on bony structures after automatic semi-rigid fusion alongside the 3 axis (x, y, z), 2) planning CT and CBCT were matched on the prostate with respect to intra-prostatic markers: xsoft, ysoft, zsoft. The position of the prostate within the pelvis for each pre- and post-treatment study points was defined as xpros= (xbone – xsoft), ypros= (ybone – ysoft) and zpros= (zbone – zsoft). Rectum and bladder were outlined on each CBCT with the aim to assess changes in rectal or vesical repletion during each fraction. Organ distension was assessed by measuring the average rectal cross-sectional area (rCSA; defined as the rectal volume divided by length), and the area of the bladder when evaluated 2.5cm above the prostate base (A-blad) on pre- and post-treatment CBCT. Results: Two hundred and ninety four CBCT were reviewed for this analysis. The average fraction duration was shorter with IMAT than with IMRT (4’49’’, vs. 11’00’’, p< 0.001). During fractions of IMRT the prostate showed statistically significant shifts in the longitudinal (p= 0,049) and lateral (p=0,013) axis while it was not statistically significant during fractions of IMAT. Intra-fraction rCSA increased neither during IMAT nor IMRT whereas A-blad increased only during fractions of IMRT but with no correlation with prostate displacements. Conclusions: The prostate moves within the pelvis during an IMRT course which could lead to a greater daily geographic miss when compared to the IMAT technique.
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Jain, Varsha, Peyton Irmen, Shannon O'Reilly, Jennifer H. Vogel, Liyong Lin, and Alexander Lin. "Predicted Secondary Malignancies following Proton versus Photon Radiation for Oropharyngeal Cancers." International Journal of Particle Therapy 6, no. 4 (March 1, 2020): 1–10. http://dx.doi.org/10.14338/ijpt-19-00076.1.

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Abstract Purpose There has been a recent epidemic of human papillomavirus (HPV)–positive oropharyngeal cancer, accounting for 70% to 80% of diagnosed cases. These patients have an overall favorable prognosis and are typically treated with a combination of surgery, chemotherapy, and radiation. Because these patients live longer, they are at risk of secondary malignant neoplasms (SMNs) associated with radiation therapy. Therefore, we assessed the predicted risk of SMNs after adjuvant radiation therapy with intensity-modulated proton therapy (IMPT) compared with intensity modulated photon radiation therapy (IMRT) in patients with HPV- positive oropharyngeal cancers after complete resection. Materials and Methods Thirteen consecutive patients with HPV-positive oropharyngeal cancers treated with postoperative radiation alone were selected. All patients were treated with pencil beam scanning IMPT to a total dose of 60 Gy in 2 Gy fractions. The IMRT plans were generated for clinical backup and were used for comparative purposes. The SMN risk was calculated based on an organ equivalent dose model for the linear-exponential dose-response curve. Results Median age of the patient cohort was 63 years (range, 47-73 years). There was no difference in target coverage between IMPT and IMRT plans. We noted significant reductions in mean mandible, contralateral parotid, lung and skin organ equivalent doses with IMPT compared with IMRT plans (P < .001). Additionally, a significant decrease in the risk of SMNs with IMPT was observed for all the evaluated organs. Per our analysis, for patients with oropharyngeal cancers diagnosed at a national median age of 54 years with an average life expectancy of 27 years (per national Social Security data), 4 excess SMNs per 100 patients could be avoided by treating them with IMPT versus IMRT. Conclusions Treatment with IMPT can achieve comparable target dose coverage while significantly reducing the dose to healthy organs, which can lead to fewer predicted SMNs compared with IMRT.
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Patrice Aka, Fleman, Roger Taylor, Richard Hugtenburg, Jamil Lambert, and James Powell. "Hippocampal sparing radiotherapy in adults with primary brain tumours: a comparative planning and dosimetric study using IMPT, IMRT and 3DCRT." Neuro-Oncology 21, Supplement_4 (October 2019): iv2—iv3. http://dx.doi.org/10.1093/neuonc/noz167.008.

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Abstract Introduction We assessed the feasibility of hippocampal sparing in adults with primary brain tumours using Intensity Modulated Proton Therapy (IMPT) and compared this with Intensity Modulated Radiotherapy (IMRT) and 3D-Conformal Radiotherapy (3DCRT). Methods and Materials 20 patients were identified, and each patient underwent a radiotherapy planning CT scan and 2 MRI scans. A pre-operative diagnostic MRI scan was fused with the planning CT and used for target delineation and a dedicated 3T MRI scan at the time of planning was fused with the CT for hippocampus delineation. 3 hippocampal sparing plans were generated for each patient with specific prescriptions (54Gy/30 fractions, 60Gy/30 fractions and 59.4Gy/33 fractions) using IMPT, IMRT and 3DCRT. Hippocampal sparing was defined as median dose to contralateral hippocampus ≤25Gy without compromising target coverage and organ at risk dose constraints. Results Hippocampal sparing was achieved in 19 patients (95%) with IMPT, 16 patients (80%) with IMRT and 13 patients (65%) with 3DCRT. The largest median hippocampal dose reduction was seen with IMPT, with a mean median hippocampal dose of 4.8Gy (range: 0.0Gy-24.9Gy), 14.6Gy (range: 1.9Gy-21.7Gy), and 16.2Gy (range: 2.3Gy-25.0Gy) for IMPT, IMRT and 3DCRT respectively. Hippocampal sparing IMPT failed in one case with the largest tumour volume (650cc) where 2/3 of the hippocampus overlapped the target volume. Conclusion IMPT as compared to IMRT and 3DCRT plans showed a trend towards significant and effective hippocampal sparing in adult patients with primary brain tumours. We are currently evaluating this in a larger patient cohort and comparing IMPT with VMAT.
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Wong, Ru Xin, Jacqueline Faught, Melissa Gargone, William Myers, Matthew Krasin, Austin Faught, and Sahaja Acharya. "Cardiac-Sparing and Breast-Sparing Whole Lung Irradiation Using Intensity-Modulated Proton Therapy." International Journal of Particle Therapy 7, no. 4 (March 1, 2021): 65–73. http://dx.doi.org/10.14338/ijpt-20-00079.1.

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Abstract Purpose Whole lung irradiation (WLI) is indicated for certain pediatric patients with lung metastases. This study investigated whether WLI delivered as intensity-modulated proton therapy (IMPT) could significantly spare the heart and breasts when compared with conventional WLI delivered with anteroposterior/posteroanterior photon fields and with intensity-modulated photon therapy (IMRT) WLI. Materials and Methods Conventional, IMRT, and IMPT plans were generated for 5 patients (aged 5-22 years). The prescription dose was 16.5 GyRBE in 1.5-GyRBE fractions. Conventional plans used 6-MV photons prescribed to the midline and a field-in-field technique to cover the planning target volume (the internal target volume [ITV] + 1 cm). IMRT plans used 6-MV photons with a 7-beam arrangement with dose prescribed to the planning target volume. IMPT plans used scenario-based optimization with 5% range uncertainty and 5-mm positional uncertainty to cover the ITV robustly. Monte Carlo dose calculation was used for all IMPT plans. Doses were compared with paired Student t test. Results The ITV Dmean was similar for the IMPT, conventional, and IMRT plans, but the IMPT plans had a lower Dmin and a higher Dmax at tissue interfaces than conventional plans (Dmean ratio: 0.96, P > .05; Dmin ratio: 0.9, P < .001; Dmax ratio: 1.1, P = .014). Dmeans for breast and heart substructures were lower with IMPT plans than with conventional/IMRT plans (heart ratios, 0.63:0.73; left ventricle ratios, 0.61:0.72; right ventricle ratios, 0.45:0.57; left atrium ratios, 0.79:0.85; right atrium ratios, 0.81:0.86; left breast ratios, 0.40:0.51; right breast ratio, 0.46:0.52; all P < .05). Conclusions IMPT resulted in comparable ITV coverage and lower mean doses to the heart and breasts when compared with other techniques. Whole lung irradiation delivered as IMPT warrants prospective evaluation in pediatric patients.
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Dissertations / Theses on the topic "IMRT"

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Sheta, Amal. "IMRT and Rotational IMRT (mARC) Using Flat and Unflat Photon Beams." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-208212.

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For more than 50 years attening filters have been inserted into the beam path oflinacs to produce a uniform energy fluence distribution of the photon beam and make it suitable for clinical use. Recently, linacs without flattening fifilter (Flattening FilterFree - FFF) are increasingly used in radiotherapy because of its benefifits, e.g. high dose rate (2000 MU/min), reduced scattered and leakage radiation. Hypofractionated radiotherapy is interested in the high dose rate of FFF beams to shorten the treatment delivery time (TDT) especially the FFF beams have acceptable flatness at small fifieldsizes. Radiotherapy techniques that deliver intensity-modulated beams (IMBs), e.g.Tomotherapy, intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT), deal with the non-uniformity of the FFF beam profifile and produce homogeneous dose to the target as FF beams do. Siemens modified the Artiste linac in order to enable photon beam delivery with and without a flattening fifilter. The VMAT version developed by Siemens for Artiste linacs as a novel radiation technique is a modulated arc therapy (mARC). mARC technique is available with single, double and multiple complete or partial arcs. The aims of the current study were the determination of the main characteristics of 7 MV and 11 MV FFF photon beams in comparison with their corresponding 6 MV and 10 MV FF photon beams from Artiste digital linacs. Furthermore, IMRT planning comparisons using FF and FFF photon beams were performed using an Oncentra planning system. The performance of various mARC techniques were estimated and compared with Step and Shoot (S&S) IMRT by using a RayStation planning system. The mARC plans created by FF and FFF beams were evaluated to know which technique is the best. All the treatment plans were created for simple and complex shaped target volumes. The treatment plans are compared using two parameters - plan quality and treatment effi ciency. In addition to the planning study, the plan quality assurance of IMRT and mARC plans were performed using two difffferent volumetric quality assurance devices, Delta4 and Octavius 4D. Removal of the flattening fifilter causes changes in the dosimetric features of photon beams. IMRT plans with and without flattening fifilter were clinically acceptable where both plans have similar quality. In comparison with IMRT-FF, IMRT-FFF plansrequire more MUs and for some clinical cases require longer TDT. mARC technique can deliver dose distributions that are comparable to S&S-IMRT and could be an alternative with a potential to improve the effi ciency of the IMRT treatment delivery.
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Khadija, Murshed. "A Comparative Analysis of Conventional MLC Based IMRT and Solid Compensator Based IMRT Treatment Techniques." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1264434257.

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Schiefer, Hans. "Kontrollen des Planungs-Bestrahlungsprozesses bei IMRT /." Basel : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8781.

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Matsushima, Luciana Cardoso. "Determinação das curvas de isodose e confirmação do planejamento em Radioterapia de Intensidade Modulada - IMRT convencional empregando as técnicas de termoluminescência, luminescência opticamente estimulada e detectores semicondutores." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-24042015-095037/.

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A radioterapia é uma das três principais modalidades utilizadas no tratamento de doenças malignas como o câncer; as outras duas são a quimioterapia e a radiocirurgia. Em contraste com outras especialidades médicas que necessitam principalmente do conhecimento clínico e da experiência de especialistas, a radioterapia, com a utilização da radiação ionizante no tratamento do câncer, depende do investimento pesado em tecnologias modernas e dos esforços colaborativos de diversos profissionais, cuja equipe coordenada influencia, sobremaneira, o resultado do tratamento. A Radioterapia de intensidade modulada (IMRT) com o uso de colimadores multilâminas (multileaf collimators MLCs) tem o potencial para alcançar um alto grau de conformidade da dose no alvo (tumor a ser tratado) e ainda promover a proteção de tecidos normais do que a maioria de outras técnicas de tratamento, especialmente para volumes-alvo ou órgãos de risco com formatos complexos. Entretanto, estudos recentes mostraram que baixas doses de radiação podem causar tumores secundários. Esse trabalho tem como objetivo a determinação da distribuição de dose de radiação absorvida em diversas simulações de tratamentos radioterápicos com o uso de dosímetros compostos de LiF:Mg,Ti; CaSO4:Dy e Al2O3:C, utilizando um objeto simulador de polimetilmetacrilato (PMMA) empregando as seguintes técnicas dosimétricas: termoluminescência (TL), luminescência opticamente estimulada (OSL) e detectores semicondutores (diodos).<br>Radiotherapy is one of three principal treatment modalities used in the treatment of malignant diseases such as cancer; the other two are chemotherapy and radiosurgery. In contrast to other medical specialties that rely mainly on the clinical knowledge and experience of medical specialists, radiotherapy, with its use of ionizing radiation in treatment of cancer, relies heavily on modern technology and the collaborative efforts of several professionals whose coordinated team approach greatly influences the outcome of the treatment. Intensity modulated radiation therapy (IMRT) with the use of multileaf collimators (MLCs) has the potential to achieve a much higher degree of target conformity and normal tissue sparing than most other treatment techniques, especially for target volumes or organs at risk with complex shapes. However, recent studies show that low doses of radiation can cause secondary cancers. This work aims to determine the radiation dose distribution in several radiation therapy treatment simulations with use of LiF:Mg,Ti; CaSO4:Dy and Al2O3:C dosimeters using a PMMA phantom for the following dosimetry techniques: thermoluminescence, optically stimulated luminescence (OSL) and semiconductor detectors.
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Barros, Catarina da Silva. "Estudo, avaliação e optimização em radioterapia - IMRT." Master's thesis, Faculdade de Ciências e Tecnologia, 2010. http://hdl.handle.net/10362/4797.

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Mestrado Integrado em Engenharia Biomédica<br>O cancro continua ser um problema de saúde pública, apesar dos esforços e desenvolvimentos verificados na luta contra o mesmo. Estima-se que em 2030 a incidência do cancro na população mundial duplique, sendo o envelhecimento da população a principal causa apontada pela Organização Mundial de Saúde (WHO, do inglês World Health Organization Desta forma, os avanços tecnológicos na saúde têm sido constantes, trazendo desenvolvimentos essenciais no diagnóstico e tratamento das mais variadas patologias. No que concerne à radioterapia, especialidade terapêutica utilizada em cerca de 50% a 60% dos doentes oncológicos, o seu estado acompanha os panoramas mais vanguardistas. ). A radioterapia de intensidade modelada (IMRT, do inglês Intensity-Modulated Radiation Therapy), resultante da evolução da técnica de radioterapia conformacional tridimensional (3D-CRT, do inglês Three-Dimensional Conformal Radiotherapy), veio a acrescentar à conformação geométrica do feixe de radiação, a capacidade de utilização da modulação da intensidade do mesmo. Desta forma a IMRT permite uma conformação dosimétrica, que salvaguarda ao máximo a integridade das estruturas adjacentes, bem como, o escalonamento de dose, mais eficaz do ponto de vista de controlo tumoral. No entanto, este ganho em saúde faz-se acompanhar, muitas vezes, do aumento de custos. Neste contexto é essencial avaliar e quantificar os custos, e as respectivas consequências/benefícios clínicos inerentes à utilização da tecnologia. Com este projecto, realizado em contexto empresarial, pretendeu-se estudar, avaliar e elaborar propostas de optimização que visem a implementação clínica da IMRT, aplicada a patologias da próstata e mama, num Serviço de Radioterapia de um Prestador de Cuidados de Saúde (PCS) público. Neste prestador, foram analisados todos os procedimentos do workflow de 3D-CRT das patologias da cabeça e pescoço (C&P), mama e da próstata, incluindo a caracterização a nível dos recursos humanos (RH) com a respectiva duração característica de cada tarefa mapeada, quer dos recursos tecnológicos envolvidos. Visto este PCS já ter iniciado a aplicação clínica de IMRT ao cancro de C&P, foram também analisados os procedimentos referentes a esta patologia, de forma a servirem de base para a realização dos modelos de IMRT para a mama e próstata, tal como, para comparar os custos inerentes à realização desta técnica, em relação à técnica conformacional. Por último projectou-se cenários da realização IMRT ao invés da 3D-CRT no PCS em estudo, para a neoplasia que economicamente se mostrou mais favorável.
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Garcia, Aaron Nicholas. "Comparative Investigation of Dosimetric Tools in IMRT." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1187369612.

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Cruz, António Manuel Costa. "IMRT beam angle optimization using Tabu search." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/17714.

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Mestrado em Matemática e Aplicações<br>O número de pacientes com cancro continua a crescer no mundo e a Organização Mundial da Saúde considerou mesmo esta como uma das principais ameaças para a saúde e o desenvolvimento humano. Dependendo da localização e das especi cidades do tumor, existem muitos tratamentos que podem ser usados, incluindo cirurgia, quimioterapia, imunoterapia e radioterapia. A Radioterapia de Intensidade Modulada (IMRT | Intensity Modulated Radiation Therapy) é uma das modalidades mais avançadas de radioterapia, onde a otimização pode ter um papel importante no que diz respeito à qualidade do tratamento aplicado. Em IMRT, o feixe de radiação pode ser visto como se fosse constituído por vários pequenos feixes, pelo uso de um colimador multifolhas, que permite que a intensidade seja modulada. Este complexo problema de otimização pode ser dividido em três subproblemas, que estão relacionados entre si e que podem ser resolvidos sequencialmente. Para cada paciente, os ângulos de onde a radiação ir a ocorrer têm de ser determinados (problema geométrico | otimização angular). Depois, para cada um desses ângulos, o mapa de intensidades (ou fluências) tem de ser calculado (problema das intensidades | otimização das fluências). Finalmente, e necessário determinar o comportamento do colimador multifolhas, de forma a garantir que as intensidades são, de facto, atribuídas (problema de realiza ção). Em cada um destes problemas de otimização, a qualidade do tratamento atribuído depende dos modelos e algoritmos usados. Neste trabalho, a nossa atenção estará particularmente focada na otimização angular, um problema conhecido por ser altamente não-convexo, com muitos mínimos locais e com uma função objetivo que requer muito tempo de computação para ser calculada. Tal significa, respetivamente, que os algoritmos que sejam baseados no cálculo de gradientes ou que requeiram muitas avaliações da função objetivo podem não ser adequados. Assim, os procedimentos metaheurísticos podem ser uma boa alternativa para abordar este problema, visto que são capazes de escapar de mínimos locais e são conhecidos por conseguirem calcular boas soluções em problemas complexos. Neste trabalho ser a descrita uma aplicação para Pesquisa Tabu. Serão ainda apresentados os testes computacionais realizados, considerando dez casos clínicos de pacientes previamente tratados por radioterapia, pretendendo-se mostrar que a Pesquisa Tabu e capaz de melhorar os resultados obtidos através da solução equidistante, cujo uso e comum na prática clínica.<br>The number of cancer patients continues to grow worldwide and the World Health Organization has even considered cancer as one of the main threats to human health and development. Depending on the location and speci cities of the tumor, there are many treatments that can be used, including surgery, chemotherapy, immunotherapy and radiation therapy. Intensity Modulated Radiation Therapy (IMRT) is one of the most advanced radiation therapy modalities, and optimization can have a key role in the quality of the treatment delivered. In IMRT, the radiation beam can be thought of as being composed by several small beams, through the use of a multileaf collimator, allowing radiation intensity to be modulated. This complex optimization problem can be divided in three related subproblems that can be solved sequentially. For each patient, the angles from which the radiation will be delivered have to be determined (geometric problem | beam angle optimization). Then, for each of these angles, the radiation intensity map is calculated ( uence or intensity optimization). Finally, it is necessary to determine the behavior of the multileaf collimator that guarantees that the desired radiation intensities are, indeed, delivered (realization problem). In each of these optimization problems, the quality of the treatment delivered depends on the models and algorithms used. In this work the attention will be focused in beam angle optimization, a problem known to be highly non{convex, with many local minima and with an objective function that is time expensive to calculate, which, respectively, means that algorithms that are gradient{based or that require many objective function evaluations will not be adequate. Metaheuristics can be the right tool to tackle this problem, since they are capable of escaping local minima and are known to be able to calculate good solutions for complex problems. In this work, an application of Tabu Search to beam angle optimization is described. Computational results considering ten clinical cases of head{and{neck cancer patients are presented, showing that Tabu Search is capable of improving the equidistant solution usually used in clinical practice.
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Markovic, Miljenko. "Comparison of IMRT delivery methods a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=58&CISOBOX=1&REC=13.

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Heeger, Jonas [Verfasser]. "Bestrahlung von Kopf-Hals-Tumoren mit fluenzmodulierter Radiotherapie (IMRT) : Vergleich zweier IMRT-Techniken mit 3D-konformaler Bestrahlung / Jonas Heeger." Köln : Deutsche Zentralbibliothek für Medizin, 2013. http://d-nb.info/1042333823/34.

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Flosi, Adriana Aparecida. "Desenvolvimento de cálculo de unidades monitoras para IMRT." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-03042012-092734/.

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A verificação de forma independente do cálculo de dose e de unidades monitoras num plano de tratamento de IMRT é um passo importante nos procedimentos de garantia de qualidade da técnica em questão. Atualmente este verificação é baseada apenas em medidas experimentais demoradas e trabalhosas. Neste trabalho foi desenvolvido uma metodologia de cálculo de unidades monitoras de forma independente como uma nova ferramenta para garantir a qualidade e exatidão dos tratamentos de IMRT. Os valores encontrados se aproximam bastante dos valores calculados pelo sistema de planejamento utilizado, de forma que o algoritmo de cálculo desenvolvido apresentou uma concordância dentro de ± 1,8 % para uma geometria simples. Após diversos testes e com os níveis de ação devidamente estabelecidos, a verificação independente da unidade monitora para planos de tratamento de IMRT se tornará uma ferramenta efetiva e eficiente no controle de qualidade que ajuda a identificar e reduzir possíveis erros de tratamento em radioterapia. Como contribuição original deste trabalho, assegura-se aos serviços de Radioterapia a utilização da metodologia desenvolvida como ferramenta de controle de qualidade em tratamentos com IMRT. Em especial aos serviços que não dispõem de recursos econômicos para adquirirem softwares comercialmente disponíveis para o cálculo independente da unidade monitora.<br>Independent verification of dose calculations and monitor units settings of IMRT treatment plans is an important step in the quality assurance procedure for IMRT technique. At present, the verification is mainly based on experimental measurements, which are time consuming and laborious. In this work an independent methodology of monitor units calculation was developed as a new tool for IMRT treatments quality and precision assurance. The values found are near those calculated by the treatment planning system used, in a manner that the calculation algorithm demonstrated ± 1,8 % concordance in a simple geometry with the system. After several tests and the levels of action well established, the independent monitor units verification for IMRT treatment plans will become an effective and efficient tool in quality assurance, helping identification and the reduction of possible mistakes in radiotherapy treatments. To radiotherapy services is assured the use of the developed methodology as a tool of quality control in IMRT treatments as an original contribution of this work, specially those that do not dispose financial resources to acquire commercially available independent monitor unit calculus software.
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Books on the topic "IMRT"

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Bortfeld, Thomas, Rupert Schmidt-Ullrich, Wilfried De Neve, and David E. Wazer, eds. Image-Guided IMRT. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-30356-1.

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International Conference on Dose, Time, and Fractionation in Radiation Oncology (6th 2001 Madison, Wis.). Biological & physical basis of IMRT & tomotherapy. Madison, Wisc: Medical Physics Pub., 2002.

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Yeo, Inhwan Jason. A procedural guide to film dosimetry: With emphasis on IMRT. Madison, Wi: Medical Physics Pub., 2004.

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1949-, Meyer John, ed. IMRT, IGRT, SBRT: Advances in the treatment planning and delivery of radiotherapy. Basel: Karger, 2007.

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Bloi, Elimelekh ben ʻAmram. Sefer Imre Elimelekh: Imrot ḳodesh ʻal ha-Torah. Yerushala[y]im: [ḥ. mo. l., 2001.

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Alter, Abraham Mordecai, d. 1948. та Alter Avraham Mordekhai, ред. Hagadah shel Pesaḥ: ʻim leḳeṭ imrot ha-"Imre Emet". Tel-Aviv: Peʾer, 1994.

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San Francisco Radiation Oncology Conference (2009), ed. IMRT, IGRT, SBRT: Advances in the treatment planning and delivery of radiotherapy : San Francisco Radiation Oncology Conference, San Francisco, Calif., USA, April 17-19, 2009. 2nd ed. Basel: Karger, 2011.

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Hölzl, Sebastian. Stadtarchiv und Museumsarchiv IMST. Innsbruck: Amt der Tiroler Landesregierung, Abt. IVb, Tiroler Landesarchiv, 1992.

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Ballagó, Imre. Ballagó Imre. Székesfehérvár: István Király Múzeum, 1986.

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Sarkadi, Imre. Sarkadi Imre. Pécs: Alexandra, 2003.

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Book chapters on the topic "IMRT"

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Rosenzweig, Kenneth E. "IMRT Lung." In Image-Guided IMRT, 359–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-30356-1_28.

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Arthur, Douglas W., Monica M. Morris, Frank A. Vicini, and Nesrin Dogan. "Breast IMRT." In Image-Guided IMRT, 371–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-30356-1_29.

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Buyyounouski, Mark K., Eric M. Horwitz, Robert A. Price, Steve J. Feigenberg, and Alan Pollack. "Prostate IMRT." In Image-Guided IMRT, 391–410. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-30356-1_31.

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Rodriguez, Matthew G. "IMRT/VMAT." In Absolute Therapeutic Medical Physics Review, 7–12. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-14671-8_2.

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Mills, Michael D., and Shiao Y. Woo. "History of IMRT." In Intensity-Modulated Radiation Therapy, 3–14. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55486-8_1.

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Court, Laurence E., Peter Balter, and Radhe Mohan. "Principles of IMRT." In Intensity-Modulated Radiation Therapy, 15–42. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55486-8_2.

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Shibamoto, Yuta, Chikao Sugie, Hiroyuki Ogino, and Natsuo Tomita. "Radiobiology for IMRT." In Intensity-Modulated Radiation Therapy, 43–57. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55486-8_3.

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Tachibana, Hidenobu, and Tetsuo Akimoto. "IGRT for IMRT." In Intensity-Modulated Radiation Therapy, 85–112. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55486-8_5.

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Mageras, Gig S., Ellen Yorke, and Steve B. Jiang. "“4D” IMRT Delivery." In Image-Guided IMRT, 269–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-30356-1_22.

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Remeijer, Peter, and Marcel van Herk. "Imaging for IMRT." In Image-Guided IMRT, 19–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-30356-1_3.

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Conference papers on the topic "IMRT"

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Moyano, Mauricio, and Guillermo Cabrera-Guerrero. "An Integrated Beam Angle Selection and Direct Aperture Optimisation Model for the IMRT Problem." In 2024 L Latin American Computer Conference (CLEI), 1–4. IEEE, 2024. http://dx.doi.org/10.1109/clei64178.2024.10700200.

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"IMRT Track Committee." In 2008 IEEE International Conference on Signal Image Technology and Internet Based Systems. IEEE, 2008. http://dx.doi.org/10.1109/sitis.2008.7.

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S.Omar, Noor, and Runak T.Ali. "Differences among IMRT and 3D-CRT plans for patients with brain cancer Noor Sami Omar." In 4th International Conference on Biological & Health Sciences (CIC-BIOHS’2022). Cihan University, 2022. http://dx.doi.org/10.24086/biohs2022/paper.654.

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IMRT is the primary development of 3D-CRT, because it represents a dose distribution to the tumor cell in superior way also sending of highly conformal radiation to irregularly and concave shaped target volume. The purpose of the present study is to compare the dosimetric analysis of two plans of radiotherapy (IMRT) and 3D-CRT, which include target volume and organ at risk for both plans. The present study selected eight patients, seven cases with different types of brain cancer and one case with chordoma cancer, all the cases previously irradiated in Zhianawa Cancer Center. All selected cases were re-planned by both techniques. IMRT planning provides reducing the dose of both right and left optic nerve mean dose for right optic nerve 23.52 Gy and left 22.51 Gy compared with the 3D-CRT plan (right optic nerve 28.06 Gy and left 25.71 Gy). IMRT plan reduces dose of both right and left eye compared to 3D-CRT plan, the mean dose for right eye 17.53 Gy and left 13.71 Gy compared with the 3D-CRT plan (right eye 18.4 Gy and left 16.97 Gy). IMRT plan provided better target cover (PTV95%) (97.33± 1.16) for (prescribed dose of 40Gy) than 3D-CRT (96.96±1.83).
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Hernandez, M., J. M. Artacho, X. Mellado, and S. Cruz. "Smooth intensity maps for IMRT." In ICASSP 2011 - 2011 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). IEEE, 2011. http://dx.doi.org/10.1109/icassp.2011.5946508.

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Vial, Philip, Anatoly Rosenfeld, Tomas Kron, Francesco d’Errico, and Marko Moscovitch. "In vivo dosimetry for IMRT." In CONCEPTS AND TRENDS IN MEDICAL RADIATION DOSIMETRY: Proceedings of SSD Summer School. AIP, 2011. http://dx.doi.org/10.1063/1.3576165.

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"IMRT in carcinoma cervix: Maximizing the gain and nipping the side effects: RGCI experience." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685268.

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Objective: To present a single institutional experience with acute toxicity, patterns of failure and survival in carcinoma cervix treated using definitive radiotherapy with IMRT technique. Methods: It is a retrospective analysis of 64 patients with carcinoma cervix treated with definitive chemoradiation (IMRT) from April 2011 to Jan 2013. Patients with squamous or adenocarcinoma histology and no metastasis, treated with definitive radiotherapy (IMRT) with or without concurrent chemotherapy were included. Acute toxicities were presented as proportions and kaplainmeier computation was done to calculate 3 years disease free survival (DFS) and 3 years overall survival (OS). Results: Median follow up was months for the entire cohort. Mean age was 55.9 years (SD 9.93). Majority of patients (92.8%) had locally advanced disease (FIGO II and III) and squamous cell carcinoma (96.9%). Mean dose to pelvis with IMRT was 49.75 Gy (SD 1.78) followed by ICRT, EBRT boost and implant in 79.7%, 17.2% and 3.1% respectively (as indicated). Response evaluation done at 3 months of treatment completion showed 83.6% complete response, 11.5% partial response and 4.9% progressive disease. During follow up 21.6% developed recurrence - 44.4% failed locally, 16.7% at para-aortic nodal region and 38.9% at distant sites. The 3 year DFS and OS was 70.8% and 60.3% respectively. Patients had tolerable acute toxicities. Incidences of grade ≥3 acute toxicity were 3.1% for anemia, 10.9% for neutropenia, 25% for thrombocytopenia, 1.5% for nausea, 0% for vomiting, 12% for GU and 12% for GI toxicities. Incidence of grade I, II and III radiation dermatitis were 38.89%, 27.78% and 22.2% respectively. None developed grade IV radiation dermatitis. Conclusion: IMRT for carcinoma cervix seems to provide improved outcomes and toxicity profile, although it should be compared with conventional radiotherapy in a well randomized control setting so as to have true and meaningful comparison.
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John, Subhashini. "High precision radiotherapy for vulvar cancer in post renal transplantation: Dosimetric challenges." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685369.

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Background: Patients with renal transplant have a higher incidence of various malignancies. Delivery of adequate radiation dose to the pelvic target in such patients sparing the transplanted kidney is a dosimetric ordeal. Due to lack of sufficient data in the literature regarding the dose constraint of the transplanted pelvic kidney, plan evaluation becomes extremely challenging in this situation. Here we present comparative dosimetric plan evaluation data of treating a patient with carcinoma of the vulva with transplanted kidney. Methods: We compared 3D conformal radiotherapy (3DCRT) and Intensity Modulated Radiotherapy (IMRT) plans for a patient diagnosed to have carcinoma of the vulva with a transplanted kidney. Total dose of radiotherapy (63 Gy) was delivered in two phases (45 Gy in 25 fractions and 18 Gy in 10 fractions respectively). We compared dose to planning target volume (PTV), and dose to organs at risk including the transplanted kidney in these two techniques. The volumes encompassed by different isodoses (50%, 20%, 10%, 5%) were also compared. Weekly renal function test was monitored. Results: The dose received by 95% of the planning target volume in 3DCRT was 43.3 Gy (phase 1), 17.7 Gy (phase 2) and in IMRT was 43.74 Gy (phase 1), 17.3 Gy (phase 2). The mean doses received by kidney in Phase 1 3DCRT, Phase 1 IMRT, phase 2 3DCRT and phase 2 IMRT were 0.98 Gy, 3.05 Gy, 0.74 Gy, 0.13 Gy respectively. The volumes covered by 50%, 20%, 10%, 5% were higher with IMRT plan when compared with 3DCRT plans. The creatinine values remained stable through the treatment. Conclusion: Radiotherapy in renal transplanted patients can be done with high precision radiotherapy techniques with strict dosimetric and image guided set up verification.
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Feygelman, Vladimir, Benjamin E. Nelms, Anatoly Rosenfeld, Tomas Kron, Francesco d’Errico, and Marko Moscovitch. "Dose Verification in IMRT and VMAT." In CONCEPTS AND TRENDS IN MEDICAL RADIATION DOSIMETRY: Proceedings of SSD Summer School. AIP, 2011. http://dx.doi.org/10.1063/1.3576164.

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Oliveira, Nicole Cristina Cassimiro de, and Aurelio Ribeiro Leite de Oliveira. "Otimização Fuzzy no Planejamento da IMRT." In v. 10 n. 1 (2023): CNMAC 2023. SBMAC, 2023. http://dx.doi.org/10.5540/03.2023.010.01.0081.

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Dasanayake, Isuru, Issam El Naqa, and Jr-Shin Li. "Constrained Kalman filtering for IMRT optimization." In 2010 49th IEEE Conference on Decision and Control (CDC). IEEE, 2010. http://dx.doi.org/10.1109/cdc.2010.5717478.

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Reports on the topic "IMRT"

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Yang, David Y. Incorporating Model Parameter Uncertainty into Prostate IMRT Treatment Planning. Fort Belvoir, VA: Defense Technical Information Center, April 2005. http://dx.doi.org/10.21236/ada439169.

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Xing, Lei. Prostate Dose Escalation by Innovative Inverse Planning-Driven IMRT. Fort Belvoir, VA: Defense Technical Information Center, November 2005. http://dx.doi.org/10.21236/ada446396.

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Xing, Lei. Prostate Dose Escalation by a Innovative Inverse Planning-Driven IMRT. Fort Belvoir, VA: Defense Technical Information Center, November 2008. http://dx.doi.org/10.21236/ada494754.

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Xia, Ping. Multiadaptive Plan (MAP) IMRT to Accommodate Independent Movement of the Prostate and Pelvic Lymph Nodes. Fort Belvoir, VA: Defense Technical Information Center, May 2009. http://dx.doi.org/10.21236/ada511267.

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Xia, Ping. Multiadaptive Plan (MAP) IMRT to Accommodate Independent Movement of the Prostate and Pelvic Lymph Nodes. Fort Belvoir, VA: Defense Technical Information Center, December 2012. http://dx.doi.org/10.21236/ada572202.

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Xia, Ping. Multiadaptive Plan (MAP) IMRT to Accommodate Independent Movement of the Prostate and Pelvic Lymph Nodes. Fort Belvoir, VA: Defense Technical Information Center, June 2013. http://dx.doi.org/10.21236/ada582203.

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Xia, Ping. Multiadaptive Plan (MAP) IMRT to Accommodate Independent Movement of the Prostate and Pelvic Lymph Nodes. Fort Belvoir, VA: Defense Technical Information Center, December 2011. http://dx.doi.org/10.21236/ada561088.

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Kurdziel, Karen, Michael Hagan, Jeffrey Williamson, Donna McClish, Panos Fatouros, Jerry Hirsch, Rhonda Hoyle, Kristin Schmidt, Dorin Tudor, and Jie Liu. Multimodality Image-Guided HDR/IMRT in Prostate Cancer: Combined Molecular Targeting Using Nanoparticle MR, 3D MRSI, and 11C Acetate PET Imaging. Fort Belvoir, VA: Defense Technical Information Center, August 2005. http://dx.doi.org/10.21236/ada446542.

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Shumway, Dean A., Kimberly S. Corbin, Magdoleen H. Farah, Kelly E. Viola, Tarek Nayfeh, Samer Saadi, Vishal Shah, et al. Partial Breast Irradiation for Breast Cancer. Agency for Healthcare Research and Quality (AHRQ), January 2023. http://dx.doi.org/10.23970/ahrqepccer259.

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Objectives. To evaluate the comparative effectiveness and harms of partial breast irradiation (PBI) compared with whole breast irradiation (WBI) for early-stage breast cancer, and how differences in effectiveness and harms may be influenced by patient, tumor, and treatment factors, including treatment modality, target volume, dose, and fractionation. We also evaluated the relative financial toxicity of PBI versus WBI. Data sources. MEDLINE®, Embase®, Cochrane Central Registrar of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus, and various grey literature sources from database inception to June 30, 2022. Review methods. We included randomized clinical trials (RCTs) and observational studies that enrolled adult women with early-stage breast cancer who received one of six PBI modalities: multi-catheter interstitial brachytherapy, single-entry catheter brachytherapy (also known as intracavitary brachytherapy), 3-dimensional conformal external beam radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT), proton radiation therapy, intraoperative radiotherapy (IORT). Pairs of independent reviewers screened and appraised studies. Results. Twenty-three original studies with 17,510 patients evaluated the comparative effectiveness of PBI, including 14 RCTs, 6 comparative observational studies, and 3 single-arm observational studies. PBI was not significantly different from WBI in terms of ipsilateral breast recurrence (IBR), overall survival, or cancer-free survival at 5 and 10 years (high strength of evidence [SOE]). Evidence for cosmetic outcomes was insufficient. Results were generally consistent when PBI modalities were compared with WBI, whether compared individually or combined. These PBI approaches included 3DCRT, IMRT, and multi-catheter interstitial brachytherapy. Compared with WBI, 3DCRT showed no difference in IBR, overall survival, or cancer-free survival at 5 and 10 years (moderate to high SOE); IMRT showed no difference in IBR or overall survival at 5 and 10 years (low SOE); multi-catheter interstitial brachytherapy showed no difference in IBR, overall survival, or cancer-free survival at 5 years (low SOE). Compared with WBI, IORT was associated with a higher IBR rate at 5, 10, and over 10 years (high SOE), with no difference in overall survival, cancer-free survival, or mastectomy-free survival (low to high SOE). There were significantly fewer acute adverse events (AEs) with PBI compared with WBI, with no apparent difference in late AEs (moderate SOE). Data about quality of life were limited. Head-to-head comparisons between the different PBI modalities showed insufficient evidence to estimate an effect on main outcomes. There were no significant differences in IBR or other outcomes according to patient, tumor, and treatment characteristics; however, data for subgroups were insufficient to draw conclusions. Eight studies addressed concepts closely related to financial toxicity. Compared with conventionally fractionated WBI, accelerated PBI was associated with lower transportation costs and days away from work. PBI was also associated with less subjective financial difficulty at various time points after radiotherapy. Conclusions. Clinical trials that compared PBI with WBI demonstrate no significant difference in the risk of IBR. PBI is associated with fewer acute AEs and may be associated with less financial toxicity. The current evidence supports the use of PBI in appropriately selected patients with early-stage breast cancer. Further investigation is needed to evaluate the outcomes of PBI in patients with various clinical and tumor characteristics, and to define optimal radiation treatment dose and technique for PBI.
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Biswal, S., and G. Erbert. Testing of the IMRA Wattlite Laser. Office of Scientific and Technical Information (OSTI), June 2000. http://dx.doi.org/10.2172/15013505.

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