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Academic literature on the topic 'Implantable microelectrode arrays'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Implantable microelectrode arrays"

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Wei, Wen Jing, Yi Lin Song, Wen Tao Shi, Chun Xiu Liu, Ting Jun Jiang, and Xin Xia Cai. "A Novel Microelectrode Array Probe Integrated with Electrophysiology Reference Electrode for Neural Recording." Key Engineering Materials 562-565 (July 2013): 67–73. http://dx.doi.org/10.4028/www.scientific.net/kem.562-565.67.

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Nowadays, the study of brain function is advanced by implantable microelectrode arrays for they can simultaneously record signals from different groups of neurons regarding complex neural processes. This article presents the fabrication, characterization and use in vivo neural recording of an implantable microelectrode array probe which integrated with electrophysiology reference electrode. The probe was implemented on Silicon-On-Insulator (SOI) wafer using Micro-Electro-Mechanical-Systems (MEMS) methods, so the recording-site configurations and high-density electrode placement could be precisely defined. The 16 recording sites and the reference electrode were made of platinum. Double layers of platinum electrodes were used so that the width of the reference electrode was as small as 6 μm. The average impedance of the microelectrodes was 0.13 MΩ at 1 kHz. The probe has been employed to record the neural signals of rat, and the results showed that the signal-to-noise ratio (SNR) of the novel probe was as high as 10 and the ordinary probe was 3. Among the 16 recording sites, there are 9 effective sites having recorded useful signals for the probe with reference electrode and 6 for the ordinary probe.
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Hetke, J. F., J. L. Lund, K. Najafi, K. D. Wise, and D. J. Anderson. "Silicon ribbon cables for chronically implantable microelectrode arrays." IEEE Transactions on Biomedical Engineering 41, no. 4 (April 1994): 314–21. http://dx.doi.org/10.1109/10.284959.

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Zarifi, Mohammad Hossein, Javad Frounchi, Mohammad Ali Tinati, and Jack W. Judy. "PLATINUM-BASED CONE MICROELECTRODES FOR IMPLANTABLE NEURAL RECORDING APPLICATIONS." Biomedical Engineering: Applications, Basis and Communications 22, no. 03 (June 2010): 249–54. http://dx.doi.org/10.4015/s1016237210001992.

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There have been significant advances in fabrication of high-density microelectrode arrays using silicon micromachining technology in neural signal recording systems. The interface between microelectrodes and chemical environment is of great interest to researchers, working on extracellular stimulation. This interface is quite complex and must be modeled carefully to match experimental results. Computer simulation is a method to increase the knowledge about these arrays and to this end the finite element method (FEM) provides a strong environment for investigation of relative changes of the electrical field extension surrounding an electrode positioned in chemical environment. In this paper FEM simulation environment is used for modeling the metal–chemical interface, which provides helpful information about noise, impedance, and bandwidth for circuit designers to design the front-end electronics of these systems, more efficiently and reliable.
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Johnson, Matthew D., Robert K. Franklin, Matthew D. Gibson, Richard B. Brown, and Daryl R. Kipke. "Implantable microelectrode arrays for simultaneous electrophysiological and neurochemical recordings." Journal of Neuroscience Methods 174, no. 1 (September 2008): 62–70. http://dx.doi.org/10.1016/j.jneumeth.2008.06.036.

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Green, Rylie A., Juan S. Ordonez, Martin Schuettler, Laura A. Poole-Warren, Nigel H. Lovell, and Gregg J. Suaning. "Cytotoxicity of implantable microelectrode arrays produced by laser micromachining." Biomaterials 31, no. 5 (February 2010): 886–93. http://dx.doi.org/10.1016/j.biomaterials.2009.09.099.

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Seymour, John P., Nick B. Langhals, David J. Anderson, and Daryl R. Kipke. "Novel multi-sided, microelectrode arrays for implantable neural applications." Biomedical Microdevices 13, no. 3 (February 8, 2011): 441–51. http://dx.doi.org/10.1007/s10544-011-9512-z.

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Ghane-Motlagh, Bahareh, and Mohamad Sawan. "High-Density Implantable Microelectrode Arrays for Brain-Machine Interface Applications." Advances in Science and Technology 96 (October 2014): 95–101. http://dx.doi.org/10.4028/www.scientific.net/ast.96.95.

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Microelectrode arrays (MEAs) act as an interface between electronic circuits and neural tissues of implantable devices. Biological response to chronic implantation of MEAs is an essential factor in determining a successful electrode design. Finding appropriate coating materials which are biocompatible and improve electrical properties of MEAs are among the main challenges. In this paper, we propose a novel, three-dimensional (3D), high-density, silicon-based MEAs for both neural recording and stimulation. Electrodes were fabricated using micromachining techniques. Geometrical features of these electrodes not only cause less tissue damage during insertion but also provide more contacts between the electrodes and targeted neural tissues. In order to achieve the proposed geometry, we introduce a novel masking method to coat variable-height electrodes with uniform and small tip-exposure. More importantly, compared to conventional techniques, the new masking method significantly improves process time and costs. This technique needs only one step masking and reduces the conventional masking steps from ten to three. In the next step, the active sites of the electrodes were coated with thin-films of molybdenum (Mo) and platinum (Pt) due to their ability to transfer between ionic and electronic current and to resist corrosion. Electrodes were characterized by scanning electron microscopy and impedance measurements. The average impedance of Mo and Pt electrodes at 1 kHz was 350 ± 50 kΩ and 150 ± 10 kΩ, respectively.
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Ji, J., and K. D. Wise. "An implantable CMOS circuit interface for multiplexed microelectrode recording arrays." IEEE Journal of Solid-State Circuits 27, no. 3 (March 1992): 433–43. http://dx.doi.org/10.1109/4.121568.

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de Haro, C., R. Mas, G. Abadal, J. Muñoz, F. Perez-Murano, and C. Domı́nguez. "Electrochemical platinum coatings for improving performance of implantable microelectrode arrays." Biomaterials 23, no. 23 (December 2002): 4515–21. http://dx.doi.org/10.1016/s0142-9612(02)00195-3.

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Black, Bryan J., Aswini Kanneganti, Alexandra Joshi-Imre, Rashed Rihani, Bitan Chakraborty, Justin Abbott, Joseph J. Pancrazio, and Stuart F. Cogan. "Chronic recording and electrochemical performance of Utah microelectrode arrays implanted in rat motor cortex." Journal of Neurophysiology 120, no. 4 (October 1, 2018): 2083–90. http://dx.doi.org/10.1152/jn.00181.2018.

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Multisite implantable electrode arrays serve as a tool to understand cortical network connectivity and plasticity. Furthermore, they enable electrical stimulation to drive plasticity, study motor/sensory mapping, or provide network input for controlling brain-computer interfaces. Neurobehavioral rodent models are prevalent in studies of motor cortex injury and recovery as well as restoration of auditory/visual cues due to their relatively low cost and ease of training. Therefore, it is important to understand the chronic performance of relevant electrode arrays in rodent models. In this report, we evaluate the chronic recording and electrochemical performance of 16-channel Utah electrode arrays, the current state-of-the-art in pre-/clinical cortical recording and stimulation, in rat motor cortex over a period of 6 mo. The single-unit active electrode yield decreased from 52.8 ± 10.0 ( week 1) to 13.4 ± 5.1% ( week 24). Similarly, the total number of single units recorded on all electrodes across all arrays decreased from 106 to 15 over the same time period. Parallel measurements of electrochemical impedance spectra and cathodic charge storage capacity exhibited significant changes in electrochemical characteristics consistent with development of electrolyte leakage pathways over time. Additionally, measurements of maximum cathodal potential excursion indicated that only a relatively small fraction of electrodes (10–35% at 1 and 24 wk postimplantation) were capable of delivering relevant currents (20 µA at 4 nC/ph) without exceeding negative or positive electrochemical potential limits. In total, our findings suggest mainly abiotic failure modes, including mechanical wire breakage as well as degradation of conducting and insulating substrates. NEW & NOTEWORTHY Multisite implantable electrode arrays serve as a tool to record cortical network activity and enable electrical stimulation to drive plasticity or provide network feedback. The use of rodent models in these fields is prevalent. We evaluated chronic recording and electrochemical performance of 16-channel Utah electrode arrays in rat motor cortex over a period of 6 mo. We primarily observed abiotic failure modes suggestive of mechanical wire breakage and/or degradation of insulation.
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Dissertations / Theses on the topic "Implantable microelectrode arrays"

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Maghribi, M. "Microfabrication of an Implantable silicone Microelectrode array for an epiretinal prosthesis." Washington, D.C : Oak Ridge, Tenn. : United States. Dept. of Energy ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2003. http://www.osti.gov/servlets/purl/15005780-5uYpbJ/native/.

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Thesis (Ph.D.); Submitted to the Univ. of California, Davis, CA (US); 10 Jun 2003.
Published through the Information Bridge: DOE Scientific and Technical Information. "UCRL-LR-153347" Maghribi, M. 06/10/2003. Report is also available in paper and microfiche from NTIS.
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Maghribi, Mariam Nader. "Microfabrication of an implantable silicone microelectrode array for an epiretinal prosthesis /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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Gabran, Salam. "Intra-Cortical Microelectrode Arrays for Neuro-Interfacing." Thesis, 2012. http://hdl.handle.net/10012/7094.

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Neuro-engineering is an emerging multi-disciplinary domain which investigates the electrophysiological activities of the nervous system. It provides procedures and techniques to explore, analyze and characterize the functions of the different components comprising the nervous system. Neuro-engineering is not limited to research applications; it is employed in developing unconventional therapeutic techniques for treating different neurological disorders and restoring lost sensory or motor functions. Microelectrodes are principal elements in functional electric stimulation (FES) systems used in electrophysiological procedures. They are used in establishing an interface with the individual neurons or in clusters to record activities and communications, as well as modulate neuron behaviour through stimulation. Microelectrode technologies progressed through several modifications and innovations to improve their functionality and usability. However, conventional electrode technologies are open to further development, and advancement in microelectrodes technology will progressively meliorate the neuro-interfacing and electrotherapeutic techniques. This research introduced design methodology and fabrication processes for intra-cortical microelectrodes capable of befitting a wide range of design requirements and applications. The design process was employed in developing and implementing an ensemble of intra-cortical microelectrodes customized for different neuro-interfacing applications. The proposed designs presented several innovations and novelties. The research addressed practical considerations including assembly and interconnection to external circuitry. The research was concluded by exhibiting the Waterloo Array which is a high channel count flexible 3-D neuro-interfacing array. Finally, the dissertation was concluded by demonstrating the characterization, in vitro and acute in vivo testing results of the Waterloo Array. The implemented electrodes were tested and benchmarked against commercial equivalents and the results manifested improvement in the electrode performance compared to conventional electrodes. Electrode testing and evaluation were conducted in the Krembil Neuroscience Centre Research Lab (Toronto Western Hospital), and the Neurosciences & Mental Health Research Institute (the Sick Kids hospital). The research results and outcomes are currently being employed in developing chronic intra-cortical and electrocorticography (ECoG) electrode arrays for the epilepsy research and rodents nervous system investigations. The introduced electrode technologies will be used to develop customized designs for the clinical research labs collaborating with CIRFE Lab.
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Yu, Zheng-lin, and 余政霖. "Fabrication and Layout Improvement of Implantable Microelectrode Array Probes for Biosensing Applications." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/59303984446491851010.

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碩士
國立臺灣科技大學
化學工程系
102
In this research, the semiconductor manufacturing technology we used to fabricate implantable microelectrode array (MEA) probes. The manufacturing process that we used included thermal oxidation, photolithography, thin film deposition and etching. We optimized each processing step in order to make miniaturized and low-cost microelectrode array probes with good spatial resolution, high production rate, and high yield. The process can be divided into three parts. The first part is the formation of metal layer on the probes that defined electrode sites, channels and bonding pads. The photolithography technology and metal deposition technology by electron beam evaporator were used to transfer the metal pattern on the substrate. The second part is the passivation process of probe surface. The dielectric layer was deposited on the probe to prevent short circuit. Therefore, after the formation of metal layer, plasma enhanced chemical vapor deposition (PECVD) was used to deposit dielectric layer. Then the electrode sites and the bonding pads defined by the second photolithography process were etched to expose their metal surfaces. The third part is the definition of probe outline. The third photolithography process was used to define the pattern of probe outline and then, the etching process was used to etch the outline to the bottom of the substrate in order to make the probes releasable from the wafer. In the whole process, photolithography is the most difficult and complicated step; however, we can modify the pattern of the probe layout to improve the process conditions. In this research, we also focused on the layout design of MEA probes and hoped to improve the process efficiency and the yield of MEA probes. The cost of this manufacturing process is a major consideration; therefore, we compared different processing method and chose better processing parameters for our process in order to establish an optimized MEA manufacturing process for the production of probes with high production rate and yield.
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Book chapters on the topic "Implantable microelectrode arrays"

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Cheung, Karen C. "Thin-Film Microelectrode Arrays for Biomedical Applications." In Implantable Neural Prostheses 2, 157–90. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-98120-8_6.

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Kandagor, Vincent, Carlos J. Cela, Charlene A. Sanders, Elias Greenbaum, Gianluca Lazzi, David D. Zhou, Richard Castro, Sanjay Gaikwad, and Jim Little. "In Situ Characterization of Stimulating Microelectrode Arrays: Study of an Idealized Structure Based on Argus II Retinal implants." In Implantable Neural Prostheses 2, 139–56. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-98120-8_5.

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Jun, Sang Beom. "Implantable Brain Interface: High-Density Microelectrode Array for Neural Recording." In KAIST Research Series, 75–105. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9981-2_4.

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Conference papers on the topic "Implantable microelectrode arrays"

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Park, Sei Jin, Anna Ivanovskaya, and Allison Yorita. "Synthesis and Fabrication of Single Walled Carbon Nanotube Microelectrode Arrays on Flexible Probes for Neurotransmitter Detection." In ASME 2022 17th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/msec2022-85273.

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Abstract Implantable microelectrode arrays are an effective method for understanding neurotransmitter dynamics with high spatial resolution. In particular, carbon-based electrodes are efficient for electrochemical detection of dopamine, a neurotransmitter studied for its role in motor movement and reward-seeking behavior. However, very few options exist for arrayed carbon microelectrodes, specifically on flexible polymeric probes. We demonstrate fabrication of polyimide probes featuring single walled carbon nanotube (SWCNT) microelectrode arrays and characterize their dopamine detection performance. First, SWCNT synthesis parameters were optimized to grow high density SWCNT “forests” that have uniform height with electrode diameters ranging from 15 μm to 100 μm, as these dimensions are spatially relevant to chemical sensing in an animal model. These SWCNT microelectrodes were then incorporated into a microfabrication process involving deposition and patterning of polyimide substrate and metal traces. The process flow was designed such that the polyimide was not exposed to the high temperatures required to grow SWCNTs. Instead, a bottom-up approach was utilized, in which the SWCNT catalyst was first patterned, the SWCNTs were synthesized on a silicon substrate, then polyimide and trace metal layers were deposited and patterned. Prototype probes were fabricated containing the same range of electrode diameters as those used for SWCNT synthesis development to determine the effect of electrode diameter on ease of microfabrication. Microelectrodes ranging from 15 μm to 50 μm in diameter were found to release from the carrier wafer more easily, while larger electrodes demonstrated poor release. These probes demonstrate a concentration-dependent response to dopamine, with high sensitivity compared to microelectrode arrays consisting of bare metal. Further development of this electrode material will enable neuroscientists to study dopamine at higher spatial resolution, with the benefit of utilizing flexible probes.
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Ji, J., and K. D. Wise. "An implantable CMOS analog signal processor for multiplexed microelectrode recording arrays." In IEEE 4th Technical Digest on Solid-State Sensor and Actuator Workshop. IEEE, 1990. http://dx.doi.org/10.1109/solsen.1990.109831.

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Xiao, Guihua, Yilin Song, Yu Zhang, Shengwei Xu, Fei Gao, Jingyu Xie, Mixia Wang, Huabing Yin, Tianhong Cui, and Xinxia Cai. "Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice *." In 2019 IEEE 19th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2019. http://dx.doi.org/10.1109/nano46743.2019.8993886.

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Lu, Zeying, Shengwei Xu, Hao Wang, Juntao Liu, Yun Wang, Jingyu Xie, Yilin Song, et al. "Implantable Microelectrode Arrays for Electrophysiological Activity Detection in Cortex of Sleep Deprived Rats *." In 2019 IEEE 19th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2019. http://dx.doi.org/10.1109/nano46743.2019.8993920.

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Wang, Mixia, Yilin Song, Song Zhang, Shengwei Xu, Guihua Xiao, Ziyue Li, Fei Gao, et al. "Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non- human Primate of Parkinson’s Disease using Implantable Microelectrode Arrays." In 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2018. http://dx.doi.org/10.1109/embc.2018.8512999.

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Alahi, Md Eshrat E., Zhou Tian, Sara Khademi, Hao Wang, and Tianzhun Wu. "Slippery coated Implantable flexible microelectrode array (fMEA) for High-Performance Neural Interface." In 2021 IEEE 16th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2021. http://dx.doi.org/10.1109/nems51815.2021.9451468.

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Tooker, A., K. G. Shah, V. Tolosa, H. Sheth, S. Felix, T. Delima, and S. Pannu. "CHRONICALLY IMPLANTABLE, 121-CHANNEL, POLYMER MICROELECTRODE ARRAY WITH HERMETICALLY-SEALED WIRELESS INTERFACE." In 2012 Solid-State, Actuators, and Microsystems Workshop. San Diego: Transducer Research Foundation, 2012. http://dx.doi.org/10.31438/trf.hh2012.41.

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Patrick, E., V. Sankar, W. Rowe, J. C. Sanchez, and T. Nishida. "An implantable integrated low-power amplifier-microelectrode array for Brain-Machine Interfaces." In 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010). IEEE, 2010. http://dx.doi.org/10.1109/iembs.2010.5626419.

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Patrick, Erin, Viswanath Sankar, William Rowe, Sheng-Feng Yen, Justin C. Sanchez, and Toshikazu Nishida. "Flexible polymer substrate and tungsten microelectrode array for an implantable neural recording system." In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2008. http://dx.doi.org/10.1109/iembs.2008.4649874.

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Zhang, Song, Yilin Song, Jun Jia, Guihua Xiao, Lili Yang, Min Sun, Mixia Wang, and Xinxia Cai. "An implantable microelectrode array for dopamine and electrophysiological recordings in response to L-dopa therapy for Parkinson's disease." In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2016. http://dx.doi.org/10.1109/embc.2016.7591098.

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Reports on the topic "Implantable microelectrode arrays"

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Maghribi, Mariam Nader. Microfabrication of an Implantable silicone Microelectrode array for an epiretinal prosthesis. Office of Scientific and Technical Information (OSTI), June 2003. http://dx.doi.org/10.2172/15005780.

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