Academic literature on the topic 'Implantable microelectrode arrays'

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Journal articles on the topic "Implantable microelectrode arrays"

1

Wei, Wen Jing, Yi Lin Song, Wen Tao Shi, Chun Xiu Liu, Ting Jun Jiang, and Xin Xia Cai. "A Novel Microelectrode Array Probe Integrated with Electrophysiology Reference Electrode for Neural Recording." Key Engineering Materials 562-565 (July 2013): 67–73. http://dx.doi.org/10.4028/www.scientific.net/kem.562-565.67.

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Nowadays, the study of brain function is advanced by implantable microelectrode arrays for they can simultaneously record signals from different groups of neurons regarding complex neural processes. This article presents the fabrication, characterization and use in vivo neural recording of an implantable microelectrode array probe which integrated with electrophysiology reference electrode. The probe was implemented on Silicon-On-Insulator (SOI) wafer using Micro-Electro-Mechanical-Systems (MEMS) methods, so the recording-site configurations and high-density electrode placement could be precisely defined. The 16 recording sites and the reference electrode were made of platinum. Double layers of platinum electrodes were used so that the width of the reference electrode was as small as 6 μm. The average impedance of the microelectrodes was 0.13 MΩ at 1 kHz. The probe has been employed to record the neural signals of rat, and the results showed that the signal-to-noise ratio (SNR) of the novel probe was as high as 10 and the ordinary probe was 3. Among the 16 recording sites, there are 9 effective sites having recorded useful signals for the probe with reference electrode and 6 for the ordinary probe.
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2

Hetke, J. F., J. L. Lund, K. Najafi, K. D. Wise, and D. J. Anderson. "Silicon ribbon cables for chronically implantable microelectrode arrays." IEEE Transactions on Biomedical Engineering 41, no. 4 (1994): 314–21. http://dx.doi.org/10.1109/10.284959.

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3

Zarifi, Mohammad Hossein, Javad Frounchi, Mohammad Ali Tinati, and Jack W. Judy. "PLATINUM-BASED CONE MICROELECTRODES FOR IMPLANTABLE NEURAL RECORDING APPLICATIONS." Biomedical Engineering: Applications, Basis and Communications 22, no. 03 (2010): 249–54. http://dx.doi.org/10.4015/s1016237210001992.

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There have been significant advances in fabrication of high-density microelectrode arrays using silicon micromachining technology in neural signal recording systems. The interface between microelectrodes and chemical environment is of great interest to researchers, working on extracellular stimulation. This interface is quite complex and must be modeled carefully to match experimental results. Computer simulation is a method to increase the knowledge about these arrays and to this end the finite element method (FEM) provides a strong environment for investigation of relative changes of the electrical field extension surrounding an electrode positioned in chemical environment. In this paper FEM simulation environment is used for modeling the metal–chemical interface, which provides helpful information about noise, impedance, and bandwidth for circuit designers to design the front-end electronics of these systems, more efficiently and reliable.
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4

Johnson, Matthew D., Robert K. Franklin, Matthew D. Gibson, Richard B. Brown, and Daryl R. Kipke. "Implantable microelectrode arrays for simultaneous electrophysiological and neurochemical recordings." Journal of Neuroscience Methods 174, no. 1 (2008): 62–70. http://dx.doi.org/10.1016/j.jneumeth.2008.06.036.

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5

Green, Rylie A., Juan S. Ordonez, Martin Schuettler, Laura A. Poole-Warren, Nigel H. Lovell, and Gregg J. Suaning. "Cytotoxicity of implantable microelectrode arrays produced by laser micromachining." Biomaterials 31, no. 5 (2010): 886–93. http://dx.doi.org/10.1016/j.biomaterials.2009.09.099.

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6

Seymour, John P., Nick B. Langhals, David J. Anderson, and Daryl R. Kipke. "Novel multi-sided, microelectrode arrays for implantable neural applications." Biomedical Microdevices 13, no. 3 (2011): 441–51. http://dx.doi.org/10.1007/s10544-011-9512-z.

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7

Ghane-Motlagh, Bahareh, and Mohamad Sawan. "High-Density Implantable Microelectrode Arrays for Brain-Machine Interface Applications." Advances in Science and Technology 96 (October 2014): 95–101. http://dx.doi.org/10.4028/www.scientific.net/ast.96.95.

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Microelectrode arrays (MEAs) act as an interface between electronic circuits and neural tissues of implantable devices. Biological response to chronic implantation of MEAs is an essential factor in determining a successful electrode design. Finding appropriate coating materials which are biocompatible and improve electrical properties of MEAs are among the main challenges. In this paper, we propose a novel, three-dimensional (3D), high-density, silicon-based MEAs for both neural recording and stimulation. Electrodes were fabricated using micromachining techniques. Geometrical features of these electrodes not only cause less tissue damage during insertion but also provide more contacts between the electrodes and targeted neural tissues. In order to achieve the proposed geometry, we introduce a novel masking method to coat variable-height electrodes with uniform and small tip-exposure. More importantly, compared to conventional techniques, the new masking method significantly improves process time and costs. This technique needs only one step masking and reduces the conventional masking steps from ten to three. In the next step, the active sites of the electrodes were coated with thin-films of molybdenum (Mo) and platinum (Pt) due to their ability to transfer between ionic and electronic current and to resist corrosion. Electrodes were characterized by scanning electron microscopy and impedance measurements. The average impedance of Mo and Pt electrodes at 1 kHz was 350 ± 50 kΩ and 150 ± 10 kΩ, respectively.
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8

Ji, J., and K. D. Wise. "An implantable CMOS circuit interface for multiplexed microelectrode recording arrays." IEEE Journal of Solid-State Circuits 27, no. 3 (1992): 433–43. http://dx.doi.org/10.1109/4.121568.

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9

de Haro, C., R. Mas, G. Abadal, J. Muñoz, F. Perez-Murano, and C. Domı́nguez. "Electrochemical platinum coatings for improving performance of implantable microelectrode arrays." Biomaterials 23, no. 23 (2002): 4515–21. http://dx.doi.org/10.1016/s0142-9612(02)00195-3.

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10

Black, Bryan J., Aswini Kanneganti, Alexandra Joshi-Imre, et al. "Chronic recording and electrochemical performance of Utah microelectrode arrays implanted in rat motor cortex." Journal of Neurophysiology 120, no. 4 (2018): 2083–90. http://dx.doi.org/10.1152/jn.00181.2018.

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Multisite implantable electrode arrays serve as a tool to understand cortical network connectivity and plasticity. Furthermore, they enable electrical stimulation to drive plasticity, study motor/sensory mapping, or provide network input for controlling brain-computer interfaces. Neurobehavioral rodent models are prevalent in studies of motor cortex injury and recovery as well as restoration of auditory/visual cues due to their relatively low cost and ease of training. Therefore, it is important to understand the chronic performance of relevant electrode arrays in rodent models. In this report, we evaluate the chronic recording and electrochemical performance of 16-channel Utah electrode arrays, the current state-of-the-art in pre-/clinical cortical recording and stimulation, in rat motor cortex over a period of 6 mo. The single-unit active electrode yield decreased from 52.8 ± 10.0 ( week 1) to 13.4 ± 5.1% ( week 24). Similarly, the total number of single units recorded on all electrodes across all arrays decreased from 106 to 15 over the same time period. Parallel measurements of electrochemical impedance spectra and cathodic charge storage capacity exhibited significant changes in electrochemical characteristics consistent with development of electrolyte leakage pathways over time. Additionally, measurements of maximum cathodal potential excursion indicated that only a relatively small fraction of electrodes (10–35% at 1 and 24 wk postimplantation) were capable of delivering relevant currents (20 µA at 4 nC/ph) without exceeding negative or positive electrochemical potential limits. In total, our findings suggest mainly abiotic failure modes, including mechanical wire breakage as well as degradation of conducting and insulating substrates. NEW & NOTEWORTHY Multisite implantable electrode arrays serve as a tool to record cortical network activity and enable electrical stimulation to drive plasticity or provide network feedback. The use of rodent models in these fields is prevalent. We evaluated chronic recording and electrochemical performance of 16-channel Utah electrode arrays in rat motor cortex over a period of 6 mo. We primarily observed abiotic failure modes suggestive of mechanical wire breakage and/or degradation of insulation.
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