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Dissertations / Theses on the topic 'Implantable biosensors'

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1

Wang, Ning. "Electrospun membranes for implantable glucose biosensors." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/8718.

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The goal for this thesis was to apply electrospun biomimetic coatings on implantable glucose biosensors and test their efficacy as mass-transport limiting and tissue engineering membranes, with special focus on achieving reliable and long sensing life-time for biosensors when implanted in the body. The 3D structure of electrospun membranes provides the unique combination of extensively interconnected pores, large pore volumes and mechanical strength, which are anticipated to improving sensor sensitivity. Their structure also mimics the 3D architecture of natural extracellular matrix (ECM), whi
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2

Katic, Janko. "Efficient Energy Harvesting Interface for Implantable Biosensors." Licentiate thesis, KTH, Integrerade komponenter och kretsar, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-163562.

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Energy harvesting is identified as a promising alternative solution for powering implantable biosensors. It can completely replace the batteries, which are introducing many limitations, and it enables the development of self-powered implantable biosensors. An interface circuit is necessary to correct for differences in the voltage and power levels provided by an energy harvesting device from one side, and required by biosensor circuits from another. This thesis investigates the available energy harvesting sources within the human body, selects the most suitable one and proposes the power manag
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Katic, Janko. "Highly-Efficient Energy Harvesting Interfaces for Implantable Biosensors." Doctoral thesis, KTH, Integrerade komponenter och kretsar, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-206588.

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Energy harvesting is identified as an alternative solution for powering implantable biosensors. It can potentially enable the development of self-powered implants if the harvested energy is properly handled. This development implies that batteries, which impose many limitations, are replaced by miniature harvesting devices. Customized interface circuits are necessary to correct for differences in the voltage and power levels provided by harvesting devices from one side, and required by biosensor circuits from another. This thesis investigates the available harvesting sources within the human b
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4

Vasylieva, Natalia. "Implantable microelectrode biosensors for neurochemical monitoring of brain functioning." Phd thesis, INSA de Lyon, 2012. http://tel.archives-ouvertes.fr/tel-00861119.

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Identification, monitoring and quantification of biomolecules in the CNS is a field of growing interest for identifying biomarkers of neurological diseases. In this thesis, silicon needle-shaped multi-molecules sensing microprobes were developed. Our microelectrode array design comprises a needle length of 6mm with 100x50 µm2 cross-section bearing three platinum electrodes with a size of 40x200 µm and 200µm spacing between them. We have used these microprobes for simultaneous glucose and lactate monitoring, using the third electrode for control of non-specific current variations. Local microdr
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Pierce, Mary E. "Engineering a fiber-optic implantable cardiovascular biosensor /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1422954.

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6

Moore, Charles Bruce. "The development of in vivo sensors." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296869.

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7

Meenakshisundaram, Guruguhan. "Development of novel implantable sensors for biomedical oximetry." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1217427728.

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8

Rey, Jose. "Guiding Electric Fields for Electroporation Applications." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3308.

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Electroporation is the critical step in an electric field mediated drug or gene delivery protocol. Electroporation based protocols have been successfully demonstrated in cancer clinical trials, however, its impact in other applications is still under investigation. A significant roadblock to long term functioning of implantable biosensors in vivo is the tissue reaction in the form of fibrous encapsulation that results in reduced transport to the sensing element of the biosensor. In vivo gene electroporation has a great potential as a means to modify the transport properties of tissues in the p
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9

Steinberg, Matthew David. "An implantable glucose biosensor." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625092.

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10

Jaffari, Samarah A. "A potentially implantable amperometric glucose biosensor." Thesis, Cranfield University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282439.

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11

Ju, Young Min. "A Novel Biostable 3D Porous Collagen Scaffold for Implantable Biosensor." Scholar Commons, 2007. https://scholarcommons.usf.edu/etd/323.

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Diabetes is a chronic metabolic disorder whereby the body loses its ability to maintain normal glucose levels. Despite of development of implantable glucose sensors in long periods, none of the biosensors are capable of continuously monitoring glucose levels during long-term implantation reliably. Progressive loss of sensor function occurs due in part to biofouling and to the consequences of a foreign body response such as inflammation, fibrosis, and loss of vasculature. In order to improve the function and lifetime of implantable glucose sensors, a new 3D porous and bio-stable collagen scaffo
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12

Cordero, Álvarez Rafael. "Subcutaneous Monitoring of Cardiac Activity for Chronically Implanted Medical Devices." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS020.

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L'objectif de cette thèse de doctorat est le développement de capteurs et d'algorithmes pour une meilleure surveillance de l'activité cardiaque dans un défibrillateur cardioverteur implantable sous-cutané (S-ICD), et plus précisément pour améliorer la spécificité de détection des tachyarythmies dangereuses telles que la tachycardie ventriculaire (TV) et la fibrillation ventriculaire (FV) dans le S-ICD. Deux schémas de détection TV/FV indépendants ont été développés dans ce but : l'un de nature électrophysiologique et l'autre hémodynamique. Le schéma de détection électrophysiologique repose sur
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13

Ju, Young Min. "A novel bio-stable 3D porous collagen scaffold for implantable biosensor." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002354.

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14

Govindarajan, Sridhar. "Development of an implantable biosensor suitable for continuous monitoring of glutamate in the brain." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492093.

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15

Chatard, Charles. "Biocapteurs implantables pour un monitorage intracérébral minimalement invasif." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEI086/document.

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Le fonctionnement du cerveau repose sur la libération de molécules telles que les neurotransmetteurs et les métabolites dans le milieu interstitiel. L’étude de ces molécules est donc primordiale afin de mieux comprendre leur rôle physiologique et pathologique. Pour cela, les biocapteurs enzymatiques implantables sont un outil prometteur de par leurs capacités de détection quantitative, en temps réel et dans les tissus profonds. En fonction des dimensions du biocapteur, l’impact de l’implantation peut avoir des conséquences considérables sur la composition chimique du fluide interstitiel. De pl
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16

Srijanto, Bernadeta Resti Widhiyatni. "Implantable Piezoresistive Microcantilever-based Wireless Cocaine Biosensors." 2008. http://trace.tennessee.edu/utk_graddiss/347.

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Cocaine is a well-known, illegal, recreational drug that is addictive due to its effects on the mesolimbic reward pathway in the human body. Accurate and real-time measurement of the concentration of cocaine in the body as a function of time and physiological factors is a key requirement for the understanding of the use of this drug. Current methods for such measurements involve taking samples from the human body (such as blood, urine, and hair) and performing analytical chemistry tests on these samples. This techniques are relatively expensive, time consuming, and labor intensive. To address
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17

Liu, Pei-Chun, and 劉佩群. "Development of Implantable Enzyme Biosensors by Using Biomedical Polymer Protective Membrane." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/80932307311001086529.

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碩士<br>國立臺灣大學<br>電機工程學研究所<br>96<br>In our study, preparation of the three-electrode biosensors used the MEMS technology. The three-electrode biosensors measured glucose and lactate using glucose oxidase (GOD) and lactate dehydrogenase (LDH). Biomedical and implantable sensor applications require stable, reproducible, reversible, and reliable miniaturized reference electrode , made of biocompatible materials. So the present study reports the application of protective membrane on the device, which exists both biocompatibility and permselectivity, and acts as a surface coating material for the out
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18

Guan, Yanbin. "Cell-microstructured surface interactions promise for anti-biofouling activity in implantable biosensors /." 2009. http://purl.galileo.usg.edu/uga%5Fetd/guan%5Fyanbin%5F200912%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2009.<br>Directed by William S. Kisaalita. Includes articles submitted to Talanta, Sensors and actuators B: chemical, Analytical and bioanalytical chemistry, and Biomaterials. Includes bibliographical references.
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19

Munro, Elizabeth Alice. "Implantable Biosensors for Neural Imaging: A Study of Optical Modeling and Light Sources." Thesis, 2009. http://hdl.handle.net/1807/18918.

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We aim to develop an implantable, optical neural imaging device by fabricating lasers and photodiodes onto a gallium arsenide substrate. Some studies suggest that lasers exhibit higher noise than light emitting diodes (LEDs) due to coherence effects – my studies aim to quantify this noise and to guide device development. To this end, I developed a model of a fluorescent imaging device which agreed with experiment. Noise analysis performed in phantom showed that laser sources exhibit temporal and spatial noise up to 10x higher than LED sources, and in vivo noise analysis also demonstrated this
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20

Novak, Matthew Thomas. "The Effects of Implant-Associated Tissue Reactions on Implantable Glucose Sensor Performance." Diss., 2014. http://hdl.handle.net/10161/8745.

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<p>As an increasingly prevalent chronic disease, diabetes represents one of the fastest growing health burdens to both the developed and developing world. In an effort to improve the management and treatment of diabetes, implantable sensors that continuously monitor glucose levels have become popular alternatives to patient-administered finger prick measurements of blood glucose. However, following implantation, the performance of these implants suffers from inaccurate and erratic readings that compromise their useful lives. As a result, implantable glucose sensors remain limited as a platf
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21

(9189602), Tran NH Nguyen. "Printable Electrochemical Biosensors for the Detection of Neurotransmitter and Other Biological Molecule." Thesis, 2020.

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<div>Glutamate is the principal excitatory neurotransmitter in the central nervous system. As one of the most abundant neurotransmitters, glutamate plays an essential role in many processes of the central nervous system and beyond. As a result, any disruption that causes an abnormal glutamate level can significantly impact the central nervous system's neurological functions. Glutamate excitotoxicity is a neuropathology that persists in many neurodegenerative disorders such as Parkinson's and Alzheimer's disease as well as in the traumatic brain and spinal cord injuries. Thus, the ability to ob
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22

"A novel biostable three-dimensional porous collagen scaffold for implantable biosensor." UNIVERSITY OF SOUTH FLORIDA, 2009. http://pqdtopen.proquest.com/#viewpdf?dispub=3326113.

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23

Yang, Yang-Li, and 楊泱澧. "Design, implementation and in vivo studies of an implantable glucose biosensor." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/43120473037651856685.

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博士<br>中原大學<br>生物醫學工程研究所<br>99<br>This thesis developed an implantable wireless glucose sensing system and studied its functionality in rats. The system includes an external controller for serving as a human-system interaction interface and an implant unit for electrochemically sensing glucose. The communications between the controller and the implant are through a pair of antenna (or coils) based on peer-to-peer radio frequency (RF) technology. The electric power of the implant is supplied by the controller by means of RF coupling. The commands issued from the controller to the implant and the
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24

Oh, Taeho. "A Low Power Integrated Circuit for Implantable Biosensor Incorporating an On-Chip FSK Modulator." 2008. http://trace.tennessee.edu/utk_gradthes/422.

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Medical care has been significantly improved in recent years due to tremendous technological advancement in the field of CMOS technology. Among those improvements, integrated circuit design and sensing techniques have brought to the doctors more flexibility and accuracy of examinations of their patients. For example, a diabetic patient needs to visit a hospital on a regular basis for the examination and proper treatment. However, with the tremendous advancement in electronic technology, a patient can soon monitor his or her own blood glucose level at home or at office with an implantable senso
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25

Chen, Wei-Hung, and 陳威宏. "Implantable wireless enzyme biosensor for monitoring of physiological states in Streptococcus iniae infected Tilapia." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/d842x9.

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碩士<br>國立臺灣海洋大學<br>機械與機電工程學系<br>106<br>Tilapia, an economically important cultured fish in Taiwan, plays a significant role in the fisheries development. It has less tolerable attributes of cold in winter and common bacterial infections in summer. Measurements of the variation of fish blood glucose and lactate concentration is a useful index to observe the change of physiological conditions. In this study, we adopted enzyme method to developed enzymatic biofuel cells and mediator-type biosensor. Enzymatic biofuel cell that consists of a needle bioanode used for glucose dehydrogenase (GDH) and a
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26

Chen, Hong-Ru, and 陳泓儒. "Design and Fabrication of Implantable Electrochemical Biosensor Array Combined with Reference and Counter Electrodes Microprobes for The Application of Glutamate Detection." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/q523ad.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>105<br>In this research, we used the semiconductor manufacturing technique to fabricate implantable multi-electrode array microprobes and AutoCAD software to design masks. The process to prepare microprobes was divided into three parts, including formation of the specific pattern of platinum metal layer on the silicon wafer, etching of the specific insulation layer and defining the outline of microprobes. We have three kinds of microprobes designed on a 4-inch wafer, including 53 probes with 4 microelectrodes, 74 probes with 4 microelectrodes and 2 long electrodes, 3
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