Dissertations / Theses on the topic 'Immunomodulation'
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Hoopen, Petra ten. "Immunomodulation of jasmonate functions." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969394403.
Full textDeClue, Amy E. "Ketamine immunomodulation during endotoxemia." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6276.
Full textThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. "August 2007" Includes bibliographical references.
Kaplan, Jennifer Melissa. "Immunomodulation During Systemic Inflammation." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186158205.
Full textSanders, Robert A. "GABAA immunomodulation & infection." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9981.
Full textDemols, Anne. "Immunomodulation de la pancreatite experimentale." Doctoral thesis, Universite Libre de Bruxelles, 2003. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211321.
Full textIslander, Ulrika. "Immunomodulation by estrogen and estren /." Göteborg : Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Göteborg University, 2007. http://hdl.handle.net/2077/3123.
Full textMattsson, Lars. "Immunomodulation of collagen-induced arthritis /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4369-9/.
Full textBarber, K. A. "Immunomodulation in the NOD mouse." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596341.
Full textDua, Harminder Singh. "Immunomodulation of experimental autoimmune uveitis." Thesis, University of Aberdeen, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317710.
Full textMerly, Liza. "Immunomodulation by Shark Cartilage Extracts." FIU Digital Commons, 2011. http://digitalcommons.fiu.edu/etd/420.
Full textNorris, Carol Rose. "Immunomodulation in experimental feline asthma /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
Full textSaurer, Timothy Benjamin Lysle Donald T. "Neuroimmune mechanisms of opioid-mediated immunomodulation." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1436.
Full textTitle from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Psychology Behavioral Neuroscience." Discipline: Psychology; Department/School: Psychology.
Milioti, Natalia. "Immunomodulation of atherosclerosis using dendritic cells." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608344.
Full textPrice, Claire. "Immunomodulation by Advanced Glycation End-Products." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508487.
Full textMellor, C. M. "Immunomodulation and chemotherapy of parasitic infections." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378990.
Full textSadler, Clare Helen. "Immunomodulation during chronic murine Schistosomiasis mansoni." Thesis, University of York, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369342.
Full textSaraiva, Margarida Sofia da Silva Santos. "Immunomodulation by poxviruses : TNF receptor homologues." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619688.
Full textJones, Joanne Louise. "Long-lived immunomodulation following Campath-1H." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612015.
Full textMussai, Francis Jay. "Immunotherapy and immunomodulation for haematological malignancies." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:6120e659-0dab-4447-b4d6-75e235d3b2c8.
Full textMoreno, Navarrete José María. "Immunomodulation and metabolism: possible role of lactoferrin." Doctoral thesis, Universitat de Girona, 2011. http://hdl.handle.net/10803/36737.
Full textPer aprofundir en la relació entre el sistema immunològic innat i els trastorns metabólics, s’investiga l’efecte de la lactoferrina en els desordres metabòlics associats a l’obesitat. Els nivells circulants de lactoferrina es trobaven significativament disminuits en subjetes amb la tolerància a la glucosa alterada (AGT), i aquests es correlacionaven negativament amb trastorns metabòlics associats a obesitat i resistència a la insulina. Els canvis aminoacídics en la seva regió N-Terminal s’associaven a un perfil lipídic menys aterogènic. La producció de lactoferrina es troba reduïda en condicions d’envelliment, inflamació crònica i diabetes tipus 2. In vitro, la lactoferrina incrementava la via de senyalització de la insulina, inclús en condicions de resistència a la insulina i presentava efectes dual en la adipogenesis (antiadipogenic en 3T3-L1 i adipogenic en adipòcits humans). En conclusió, la lactoferrina podria tenir un potencial efecte protector enfront les enfermetats metabòliques associades a obesitat i resistència a la insulina.
Vallance, Bruce A. "The immunomodulation of intestinal smooth muscle function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0023/NQ51017.pdf.
Full textHjerpe, Charlotta. "Immunomodulation and its effector mechanisms in atherosclerosis /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-177-7/.
Full textZhang, Gaofeng. "Electric signals regulated immunomodulation and wound healing." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/42430/.
Full textWilliams, Richard David. "Immunomodulation of reproductive function in domestic ruminants." Thesis, University of Nottingham, 2004. http://eprints.nottingham.ac.uk/28687/.
Full textRigg, Keith Malcolm. "Immunomodulation of circulating lymphocytes in colorectal cancer." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241446.
Full textPollock, Emma. "Gluten antigenicity and immunomodulation in coeliac disease." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407704.
Full textJordan, Robert William. "Humoral immunomodulation induced by toxigenic Pasteurella multocida." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419136.
Full textChimen, Myriam. "Immunomodulation by adipokines in type 1 diabetes." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3581/.
Full textYuan, Kai. "Metabolic inflammation and immunomodulation in dairy cows." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/17294.
Full textDepartment of Animal Sciences and Industry
Barry J. Bradford
The transition period in dairy cows is characterized by dramatic increases in nutrient requirements for lactation and substantial metabolic stress. The disturbed metabolic balance, coupled with suppressed immune function, contributes to markedly elevated incidence of health disorders. Several lines of evidence suggest that increased inflammation is common during the transition period. Unlike the classical inflammation associated with acute infection, the postpartum inflammatory state is low-grade and often of metabolic origin. This metabolic inflammation plays a key role in numerous disorders; an improved understanding of inflammatory pathways in transition cows may improve our ability to predict and prevent disorders. To mimic metabolic inflammation, in Experiment 1, we administered low amounts of recombinant bovine tumor necrosis factor-α (rbTNFα), a pro-inflammatory cytokine, to early lactation cows, and evaluated whether rbTNFα affects milk production, metabolism, and health. We found that rbTNFα administration increased systemic inflammation, decreased feed intake and milk yield, and increased incidence of disorders. Conversely, preventing excessive inflammation has the potential to improve productivity and health of dairy cows. To identify nutritional strategies that could enhance metabolism and immunity, we evaluated the efficacy of several feed additives. In Experiment 2, we evaluated effects of chromium propionate, rumen-protected lysine and methionine, or both on metabolism and immunity in lactating dairy cows, and found that supplementation of these nutrients may enhance neutrophil function. In Experiment 3, we determined whether supplementation of yeast product to transition cows could enhance production, metabolism, and immunity, and found that yeast product modulated feeding behavior, metabolism, immunity, and uterine inflammation. Overall, a greater understanding of the role of metabolic inflammation in the transition period and the nutritional strategies that could modulate these signals may improve the production and health of dairy cows.
Harizi, Hedi. "Cellules dendritiques et éicosanoi͏̈des : production et immunomodulation." Bordeaux 2, 2002. http://www.theses.fr/2002BOR28957.
Full textSteck, Ryan Perry. "Pharmacologic Immunomodulation of Macrophage Activation by Caffeine." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4251.
Full textMockridge, James William. "Immunomodulation of GH activity : application and potential mechanisms." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627200.
Full textCopland, A. "The immunomodulation of dendritic cells by Neisseria meningitidis." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1472931/.
Full textMurray, Patrick Francis. "Immunomodulation within the head and neck tumour microenvironment." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10124.
Full textGautherot, Isabelle. "Anti-messagers et ribozymes : médiateurs d'une immunomodulation spécifique." Lyon 1, 2003. http://www.theses.fr/2003LYO10001.
Full textSantos, Michael Carmelo Orda. "Immunomodulation of Flavonoid Biosynthesis in Transgenic Arabidopsis thaliana." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/27349.
Full textPh. D.
Manickam, Cordelia. "IMMUNOPATHOGENESIS AND IMMUNOMODULATION INDUCED BY PRRSV STRAIN VR2332." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366361539.
Full textHietter, Hélène. "Activites biologiques des hydroxysterols : cytotoxicite selective et immunomodulation." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13323.
Full textFerreira, Daniela Filipa Alves. "Influence of substrates composition on immunomodulation by MSCs." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16048.
Full textMesenchymal stem cells (MSCs) are non-hematopoietic multipotent stem cells capable to self-renew and differentiate along different cell lineages. MSCs can be found in adult tissues and extra embryonic tissues like the umbilical cord matrix/Wharton’s Jelly (WJ). The latter constitute a good source of MSCs, being more naïve and having a higher proliferative potential than MSCs from adult tissues like the bone marrow, turning them more appealing for clinical use. It is clear that MSCs modulate both innate and adaptive immune responses and its immunodulatory effects are wide, extending to T cells and dendritic cells, being therapeutically useful for treatment of immune system disorders. Mechanotransduction is by definition the mechanism by which cells transform mechanical signals translating that information into biochemical and morphological changes. Here, we hypothesize that by culturing WJ-MSCs on distinct substrates with different stiffness and biochemical composition, may influence the immunomodulatory capacity of the cells. Here, we showed that WJ-MSCs cultured on distinct PDMS substrates presented different secretory profiles from cells cultured on regular tissue culture polystyrene plates (TCP), showing higher secretion of several cytokines analysed. Moreover, it was also shown that WJ-MSCs cultured on PDMS substrates seems to possess higher immunomodulatory capabilities and to differentially regulate the functional compartments of T cells when compared to MSCs maintained on TCP. Taken together, our results suggest that elements of mechanotransduction seem to be influencing the immunomodulatory ability of MSCs, as well as their secretory profile. Thus, future strategies will be further explored to better understand these observation and to envisage new in vitro culture conditions for MSCs aiming at distinct therapeutic approaches, namely for immune-mediated disorders.
As células estaminais mesenquimais (MSCs) são células não-hematopoéticas, multipotentes, capazes de se auto-renovar e de diferenciar em diferentes tipos celulares. As MSCs estão presentes em tecidos mesenquimais e de tecidos extra embrionários, tais como a matriz do cordão umbilical/Wharton’s Jelly(WJ). Estes últimos constituem uma boa fonte de de MSCs, sendo estas mais naive e tendo um maior potencial de proliferação do que as MSCs obtidas de tecidos adultos, como a medula óssea, tornando as MSCs da matriz do cordão umbilical/Wharton’s Jelly sejam mais apelativas para uso clínico. As MSCs possuem a capacidade de modularem tanto o sistema imune inato como o adquirido e os seus efeitos são vastos, afectando todas as células do sistema imune. Esta capacidade é bastante vantajosa para o uso terapêutico destas células em doenças do sistema imunitário. A mecanotransducção é por definição o mecanismos pelo qual as células convertem estímulos mecânicos em uma resposta bioquímica e com mudanças na sua morfologia. Apartir destas observações colocámos a hipotese de que mantendo MSCs in vitro em diferentes substratos poderia influencia a sua capacidade imunomoduladora. Com este trabalho, demonstrámos que ao plaquear MSCs em diferentes substratos de PDMS, estas mostram uma tendência para secretar quantidades diferentes de vários factores soluveis analisados, relativamente a MSCs mantidas em cultura em plataformas convencionais (placas de cultura de células - TCP). Para além disto, foi também observado que MSCs plaqueadas em substratos de PDMS aparentavam possuir uma maior capacidade imunomoduladora quando comparadas com MSCs mantidas em condições convencionais. Em conjunto todos os resultados obtidos sugerem que elementos relacionados com a mecanotransdução parecem influenciar a capacidade imunomoduladora de MSCs e a sua secreção de factores solúveis. Deste modo, estudos futuros poderão elucidar os mecanismos responsáveis por estas observações, de modo a permitir que se possa constitutuir melhores estratégias de cultura de MSCs para futuro uso terapêutico dirigido a doenças do sistema imunitário.
Harper, Fiona Helen. "The induction and immunomodulation of experimental autoimmune uveoretinitis." Thesis, University of Aberdeen, 1993. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU554654.
Full textHietter, Hélène. "Activités biologiques des hydroxystérols cytotoxicité sélective et immunomodulation." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37598306w.
Full textMcBee, Megan Earley. "Immunomodulation by subclinical persistent infection with Helicobacter hepaticus." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39916.
Full textIncludes bibliographical references (leaves 112-118).
Recognition of polymicrobial infections is becoming important for understanding differential host responses to environmental exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model of infectious colitis with particular usefulness for modeling human diarrheal disease or inflammatory bowel disease. Infection with Helicobacter hepaticus is subclinical and persistent in C57BL/6 mice, but causes disease in susceptible strains and immunodeficient mice. To test the hypothesis that subclinical persistent infection modulates the host response to diarrheal disease a polymicrobial mouse model utilizing H. hepaticus and C. rodentium was developed and characterized. Concurrent infection has been shown to modulate disease outcome through several mechanisms including: cross-reactivity between viral antigens; shifting T cell response from Th1 to Th2 by helminth infection; and induction of regulatory T cells that suppress host response. In this new model of polymicrobial infection, a new paradigm in which persistent infection prolonged the course of acute colitis associated with a deviation from Thl-biased disease to Th17 was observed.
(cont.) In addition, Foxp3+naturally-occurring regulatory T cells (nTre,) were markedly increased during active colitis. The accumulation of nTreg was sustained when mice were persistently infected with H. hepaticus, indicating on-going active colitis. Although persistent infection was able to modulate host response, protective immunity to a subsequent C. rodentium infection was not compromised. Persistent infection also modulated host response to soluble antigen by preventing induction of oral tolerance to single bolus, but not to continuous, high-dose antigen feeding. Using H. hepaticus infection of C57BL/6 mice, models to investigate the immunomodulatory potential of persistent infection on immunogenic responses of protective immunity to enteric infection, host response to polymicrobial enteric infection, as well as tolerogenic responses to soluble antigen were developed. These models establish baselines for further investigation into the influences of persistent infection on host immune responses.
by Megan Earley McBee.
Ph.D.
Belaz, Sorya. "Dérivés furanosidiques à visée thérapeutique dans la leishmaniose : caractérisation des effets et mode d'action." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B044/document.
Full textLeishmaniasis is a neglected tropical disease for which the current therapeutic arsenal is limited. This work aimed at finding new therapeutic drugs by targeting the Leishmania cell wall. Lipophosphoglycan (LPG) is the major glycoconjugate in promastigotes cell wall, consisting of a hexasaccharide core including a galactofuranose motif. Galactofuranose is absent in mammalian membranes, thus could be a therapeutic target. First, this work studied the galactofuranosyl-transferases involved in the metabolism of this furanose, as well as a mutase, also necessary for the metabolism of galactofuranose. Once targets were identified in the two parasitic stages, galactofuranose derivatives were tested for antileishmanial activity on promastigotes and amastigotes forms of Leishmania donovani. A compound showed interesting results and has been studied further, the n-octyl-galactofuranose (Galf). Different techniques have been used to characterize its mode of action on promastigotes and amastigotes: electron paramagnetic resonance, transmission electron microscopy, nuclear magnetic resonance or flow cytometry. Infected macrophages treated with Galf were able to produce oxygen derivatives species, leading us to look at the immunomodulatory capacity of Galf derivatives. Thus, the last part of this work focused on the study of macrophage polarization by galactofuranosides on an in vitro model of human macrophages. We were able to show that Galf stimulates macrophages towards M1 polarization, which could explain the decreased growth of amastigotes inside macrophage cells
Zark, S. "Mechanisms of immunomodulation by the periodontal pathogen Porphyromonas gingivalis." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546428.
Full textMorris, Rebecca Jane. "Immunomodulation of the cellular immune response by human cytomegalovirus." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55574/.
Full textQuentin, Julie. "Immunomodulation de l'arthrite expérimentale par les cellules dendritiques tolérogènes." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T018/document.
Full textTolerogenic dendritic cells for immumodulation in experimental arthritis.Dendritic cells (DCs) are the most potent antigen-presenting cells that play critical roles in the initiation and regulation of immune responses. Based on their tolerogenic properties, DCs offer potential as therapeutic tools to ameliorate or prevent graft rejection or graft-versus-host disease, or to treat autoimmune disorders.The objectives of my PhD consisted to:- reinforce the tolerogenic potential of DCs by in vitro handling.- assess the capacity of such tolerogenic DCs to induce a protective response in experimental autoimmune arthritis- identify cellular and molecular mechanisms implied in the tolerogenic DCs-induced protectionOur results suggest that, in contrast with conventional DCs, the rapamycin-conditioned iDCs maintain their tolerogenic potential upon injection in inflammatory settings and are able to dampen an already Th1-primed immune response, conferring a protection from arthritis. The protection of the mice was associated with an expansion of the IL-10-secreting CD49b+ Treg in the spleen and liver of the injected mice and a decrease of the Th1 immune response. These results underscore the therapeutic potential of tolerogenic DCs in an established autoimmune disease as well as the anti-inflammatory potential of the CD49b+ Treg cell population induced following DC vaccination
Nikolic, William Veljko. "Immunomodulation as a potential therapeutic approach for Alzheimer's disease." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002539.
Full textNikolic, William Veljko. "Immunomodulation As A Potential Therapeutic Approach For Alzheimer’s Disease." Scholar Commons, 2008. https://scholarcommons.usf.edu/etd/429.
Full textPalmerini, Emanuela <1975>. "New therapeutic approaches in sarcoma: Immunomodulation and tumor microenvironment." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8393/1/Tesi%203%20MAR%2018%20no%20pub%20awards.pdf.
Full textWhittall, Christine Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Interaction between N-(3-oxododecanoyl)-L-homoserine lactone and peroxisome proliferator-activated receptor gamma." Awarded By:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44957.
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