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Dissertations / Theses on the topic 'Immunology; Tumour cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Dearman, Rebecca Jane. "Antibody-dependent destruction of neoplastic cells by celluar effectors." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276345.

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2

McDonnell, Alison. "The role of dendritic cells in the cross-presentation of tumour antigens." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0017.

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[Truncated abstract] A paradox exists in tumour immunology whereby progressive tumour growth exists in parallel with an anti-tumour T cell response. This defective T cell response is thought to result from the induction of T cell tolerance and/or tumour induced immunosuppression, which act to inhibit the activation, differentiation and function of tumour-specific CD8+ T cells. Dendritic cells (DCs) are professional antigen presenting cells (APCs) that are critical to the generation of effective CTL; however their function and phenotype is often defective or altered in tumour-bearing hosts, whi

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3

Ajzensztejn, Daniel. "Harnessing the immune system to reject cancers through genetic modifications of tumour cells." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:1aafa1f4-ee10-4081-b621-d81b9979d96a.

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The immune system, which defends the body against a wide array of threats, is gaining a growing role in the fight against cancer. For an immunotherapy to be successful, it needs to overcome intrinsically weak tumour-specific immune responses. There are two broad approaches to achieving this goal: targeting the various arms of the immune system or targeting the cancer and its microenvironment. The experiments discussed in this thesis adopt the second approach. Tumours were transduced with a combination of costimulatory molecules: CD48, CD54, CD70 & CD86, the chemokine CX3CL1 and the cytokines:

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4

Windebank, Kevin. "Early signal transduction events during activation of the cytolytic process in human natural killer cells." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337563.

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5

Pullyblank, Anne Maria. "Evaluation of the role of monoclonal antibodies m17-1A, c17-1A and cSF25 in antibody-dependent cell-mediated cytotoxicity and an exploration of the possible mechanisms of action." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268015.

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6

Petrovic, Kristina. "Exploring the therapeutic potential of CAR-engineered T-cells targeting endothelial markers on tumour and inflamed vasculature." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8468/.

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T-cells engineered to target tumour antigens through surface-expressed chimeric antigen receptors (CARs) are highly effective in treating some leukaemias. The challenge is to extend this success to solid tumours. Tumour endothelial marker 8 (TEM8) is a conserved transmembrane protein overexpressed on the vasculature of many solid tumours but low or undetectable on healthy tissues, making it a potential CAR T -cell target. This thesis explores the safety and therapeutic efficacy of this approach by generating five human TEM8-specific CARs, expressing them in T-lymphocytes, and characterising th

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7

Nirmal, Ajit Johnson. "Deconvolution of the immune landscape of cancer transcriptomics data, its relationship to patient survival and tumour subtypes." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31519.

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The immune response to a given cancer can profoundly influence a tumour's trajectory and response to treatment, but the ability to analyse this component of the microenvironment is still limited. To this end, a number of immune marker gene signatures have been reported which were designed to enable the profiling of the immune system from transcriptomics data from tissue and blood samples. Our initial analyses of these resources suggested that these existing signatures had a number of serious deficiencies. In this study, a co-expression based approach led to the development of a new set of immu

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8

Chong, Tsung Wen. "Targeting the hypoxic tumour phenotype with specific T-cell immunotherapy." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:d22f1d74-44eb-4560-9249-f6127accd1b1.

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9

Sugiyarto, Gessa. "Characterising the preferential suppression of potent anti-tumour CTL responses by regulatory T cells." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/379016/.

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10

Li, Ka-Kit. "The role of CD8+ regulatory T cells in anti-tumour immune responses in hepatocellular carcinoma." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/7940/.

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Tumour specific effector T-cells can be detected in the blood and tumours of patients with hepatocellular carcinoma (HCC) but fail to mount effective immune responses. Attempts to amplify anti-tumour immune responses using immunotherapy show promise, but are hampered by the presence of suppressive regulatory T-cells (Treg) that inhibit anti-tumour immune responses. Many different subsets of Treg have since been identified including regulatory T-cells expressing the surface marker CD8 (CD8⁺Treg). A set of experiments was designed in an attempt to increase our understanding on how CD8⁺Treg may d

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11

Balathasan, Lukxmi. "Characterising the role of circulating immune cells in brain metastasis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e7620d30-7e4a-468b-b819-db4cf27eaef6.

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Brain metastasis is a frequent occurrence in cancer patients and carries a high mortality rate. The incidence of brain metastasis is on the rise, highlighting the need for improved therapeutic intervention. Immune cells have been shown to promote disseminated tumour cells to colonise the lung and liver. Therefore, we aim to determine whether immune cells also facilitate brain metastasis by describing the host immune response to tumour cells attached to the brain vasculature. We developed a model of brain metastasis by using ultrasound guidance to perform intracardiac injection of tumour cells.

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12

Ananth, Abhirami. "Surgical Stress Attenuates Pre-existing Anti-tumour Immunity Resulting in Postoperative Metastases and local Recurrence in a Murine Model." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31697.

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Solid malignancies in cancer patients require surgical intervention; however, surgery has been shown to promote the metastatic potential of tumour cells. Surgery-induced impairment of adaptive immunity is poorly understood, thus, our aim is to characterize the impact of surgery on tumour antigen-specific cytotoxic T lymphocyte function. To generate anti-tumour immunity, we adopted a C57/B6 model of B16 melanoma immunized with intramuscular (IM) AdhDCT, an adenovirus expressing the melanoma-associated antigen human dopachrome tautomerase (hDCT). Surgical stress was induced by left abdominal nep

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13

Jain, Jayati. "Engineering antibodies to study and improve immunomagnetic isolation of tumour cells." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:81355801-b331-4705-bfef-204a29ee0347.

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Cell separation based on antibody-targeted magnetic beads has been widely used in a number of applications in immunology, microbiology, oncology and more recently, in the isolation of circulating tumour cells (CTCs) in cancer patients. Although other cell separation techniques such as size based cell filtration and Fluorescence Activated Cell Sorting have also been in popular use, immunomagnetic cell isolation possesses the advantages of high throughput, good specificity and reduced cell stress. However, certain fundamental features of the cell-bead interface are still unknown. In this study,

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14

Vallius, Laura I. "Modulating the immune system by amino acid depletion : IDO and beyond." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:eb1a1987-4121-4042-be82-2aafb67c9941.

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Amino acid availability plays an important role in modulating the activity of T-cells. One of the pathways employed by T-cells to sense nutrient levels is the “mammalian target of rapamycin” (mTOR) pathway that is inhibited in response to nutrient depletion. Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme along the tryptophan catabolising kynurenine pathway. T-cells are very sensitive to lack of this essential amino acid in their microenvironment and this confers strong immunomodulatory properties to cells expressing active IDO. It therefore has a significant physiologi

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15

Mundy-Bosse, Bethany L. "Myeloid-Derived Suppressor Cells in Tumor Immunology." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311261626.

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16

Murray, Nicholas. "Costimulation of T cells and its role in T cell recognition of malignant colorectal cells in vitro." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301247.

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17

Karydis, Ioannis. "The role of tryptophan and the mTOR pathway in T cell fate determination." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:1831d28b-52cb-47ee-8047-f6044cd10301.

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The adaptive immune response forms an essential part of the cancer immuno-editing process, whereby nascent malignant cells are detected and destroyed prior to forming tumours. The process is tightly controlled to minimise collateral damage to healthy tissue. One of the mechanisms evolved for this purpose and frequently co-opted by malignant cells is the creation of a microenvironment scarce in essential amino-acids through the use of catabolic enzymes such as Indoleamine 2,3-dioxygenase (IDO) , responsible for the rate-limiting step in tryptophan catabolism. The evolutionary conserved GCN2 and

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18

Bell, Mary Siobhan. "Malignancy antigens of the Erlich ascites cell." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317049.

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19

Carlsten, Mattias. "Molecular specificities of NK cell-mediated recognition of human tumor cells." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-686-6/.

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20

Khan, Sarwat Tahsin. "An Interleukin-12-Expressing Oncolytic-Virus Infected Autologous Tumor Cell Vaccine Generates Potent Anti-Tumor Immune Responses." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37940.

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21

Cachia, Philip Greville. "Studies of idiotope expression in B-cell chronic lymphocytic leukaemia." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/23764.

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22

Popple, Amy Lee. "The tumour microenvironment influences antigen specific T cell transmigration." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12584/.

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T cell infiltration into tumours is essential for tumour antigen recognition and tumour cell elimination. The aim of this study was to develop a better understanding of T cell infiltration into tumours, focusing on two opposing arms of an immune response, anti-tumour CD8 Tcells and Regulatory T cells (Tregs). Activated CD4 T helper cells are also of importance but could not be studied due to the time constraints of the project. The effect of T cell signalling at the immunological synapse following interactions between T cells and APCs presenting cognate antigen have been well studied [1]. The

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23

Zhang, Tong. "Novel approaches to identify T cell-recognized tumor antigens and to redirect T cells for adoptive immunotherapy." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280461.

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Tumor antigens (Ags) and adoptive immunotherapy are two important topics in tumor immunology. Traditional methods for identifying T cell-recognized tumor antigens and adoptive therapy using antigen-specific T cells are laborious and difficult. Rapid developments in molecular biology and immunology have allowed us to design novel strategies to achieve these two goals more efficiently. A novel strategy, SING (S̲I̲gnal transduction molecule-mediated, N̲FAT-controlled, G̲FP expression), for cloning T-cell recognized tumor Ags, was designed using Ag-specific T cells. The SING system is an artificia

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24

Franchini, Fanny. "Immune regulatory networks in inflammation-driven cancer." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:2314081e-8c3f-43c7-9ea6-edf43430a43c.

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The incidence of colorectal cancer (CRC) is increasing and the prognosis for patients with advanced or metastatic disease is relatively poor. Immunotherapies hold great promise, but deploying them effectively in CRC patients will require further knowledge of the complex cellular and molecular interactions that occur between intestinal tumours and the host immune system. The objective of this study is to understand the mechanisms by which lack of immune cell regulation in the gut can drive the formation of colon adenocarcinomas. In addition, this work aims to identify new mechanisms involved in

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25

Montgomery, Anthony. "The targeting of T-helper cells to tumours using PPD-monoclonal antibody heteroconjugates." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385716.

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26

Ybarrondo, Ana-Belen. "Regulation of tumor necrosis factor and interferon-gamma release from lymphokine-activated killer cells." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185298.

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Peripheral blood lymphocytes cultured in interleukin 2 (IL-2) acquire the ability to lyse tumor cell targets in a non-major histocompatability complex (MHC) restricted manner. These lymphokine activated killer (LAK) cells release tumor necrosis factor-alpha (TNF) and interferon-gamma (IFN-γ) in culture and when stimulated by interaction with tumor cells in vitro. The capacity of several suppressive factors to affect the release of TNF and IFN-γ from LAK cells which have been stimulated with K562 erythroleukemia cells was investigated. A number of agents known to inhibit mononuclear phagocyte s

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27

Rongcun, Yang. "The HER2/neu oncoprotein and dendritic cells in immunity against tumors /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4052-5/.

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28

Baloche, Valentin. "Contributions négatives et positives de la galectine-9 au développement tumoral : étude dans des modèles tumoraux murins syngéniques In the MB49 Murine Model, Genetic Ablation of Galectin-9 Enhances Anti-Tumor Immune Response: Possible Role of a Greater CXCL9/Il-6 Production Tumor Exosomal Micrornas Thwarting Anti-Tumor Immune Responses in Nasopharyngeal Carcinomas Interferon β and Anti-PD1/PD-L1 Checkpoint Blockade Cooperate in NK Cell-Mediated Killing of Nasopharyngeal Carcinoma Cells Interferon Beta Increases NK Cell Cytotoxicity against Tumor Cells in Patients with Nasopharyngeal Carcinoma via Tumor Necrosis Factor Apoptosis-Inducing Ligand Emerging Therapeutic Targets for Nasopharyngeal Carcinoma: Opportunities and Challenges Galectin-9 Promotes a Suppressive Microenvironment in Human Cancer by Enhancing STING Degradation". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS117.

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Comme les autres galectines, la galectine-9(gal-9) est une lectine animale qui interagit avec un sous-groupe défini de polysaccharides portés par des glycoprotéines ou des glycolipides. La gal-9 associée aux cellules exerce de multiples fonctions dans le cytoplasme, dans le noyau et à la surface de la membrane plasmique. Quelques publications suggèrent que la gal-9 intra-cellulaire inhibe la mobilité des cellules malignes et exerce un effet antimétastatique. En outre la gal-9 peut être sécrétée dans le milieu extra-cellulaire où elle se comporte comme une cytokine avec des effets principalemen

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29

Blazquez, Roman Juan Luis. "Role of the BTN3A family of proteins in the recognition mechanism of tumor cells by gamma delta-T cells : characterization of physical and functional interactions goberning BTN3A biology." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0194.

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Chez la plupart des primates adultes, les lymphocytes Vγ9Vδ2 représentant la majorité des LT γδ circulants, jouent un rôle fondamentale dans l’immunité anti-infectieuse et anti-tumorale grâce à sa capacité d’identifier l’accumulation pathologique des phosphoantigènes dans les cellules infectées/ transformées. Dans ce contexte, les molécules BTN3A (glycoprotéines membranaires) ont été identifiées comme les médiateurs principaux impliqués dans l’activation des cellules Vγ9Vδ2 induite par les phosphoantigènes.Les travaux développés durant la thèse visent à étudier, grâce à la méthode CRIPSR-Cas9,

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30

Oldham, Kimberley Anne. "The recruitment and role of effector and regulatory T cells in renal cell carcinoma." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3263/.

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Immunotherapy for renal cell carcinoma (RCC) has yielded some clinical responses. However this approach frequently fails, possibly due to inefficient migration of T-cells to tumour tissue or immunosuppressive mechanisms within the tumour environment. To aid development of T-cell therapy for RCC I investigated how T-cells are recruited to this tumour, which T-cell subsets infiltrate, and how they function. Analysis of the expression of all 19 chemokine receptors on matched TIL and PBMC demonstrated that CCR5, CXCR3 and CXCR6 were expressed at significantly higher levels on tumour-infiltrating T

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31

Ko, Jennifer S. "Mechanism of Myeloid-Derived Suppressor Cell Accumulation in Cancer and Susceptibility to Reversal by Sunitinib." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1259869673.

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32

Maggs, Luke. "The role of stem cell graft derived natural killer cells in regulating patient outcomes from allogeneic haematopoietic stem cell transplantation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8633/.

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Myeloid and lymphoid malignancies are potentially curable through a graft versus leukaemia (GvL) effect following allogeneic haematopoietic stem cell transplantation. Whilst donor T cell are thought to be the main mediators of GvL, the effect of donor NK cells within HLA matched T cell depleted transplant setting is more unclear. Patient blood samples were analysed during the first month post-transplant, with higher reconstitution of NK cells at two weeks conferring a relapse protection association. Donor stem cell graft samples, from which NK cells within the patient at two weeks are thought

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33

Ortiz, Myrna Lillian. "Immature Myeloid Cells Promote Tumor Formation Via Non-Suppressive Mechanism." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5089.

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ABSTRACT Although there is ample evidence linking chronic inflammation with cancer, the cellular mechanisms involved in early events leading to tumor development remain unclear. Myeloid cells are an intricate part of inflammation. They consist of mature cells represented by macrophages, dendritic cells and granulocytes and a population of Immature Myeloid Cells (IMC), which in healthy individuals are cells in transition to mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a re

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34

Wolpert, Elisabeth Z. "T-lymphocyte mediated killing af TAP-deficient tumor cells and immunodominance of minor histocompatibility antigens /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980525wolp.

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35

Sherger, Matthew George. "Identification of Myeloid Derived Suppressor Cells in Tumor Bearing Dogs." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337617975.

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36

Meyer, Verena. "Selective analysis of specific HLA ligand repertoires: poxviral CD8+ T cell epitopes and phosphorylated HLA ligands of tumor cells." [S.l. : s.n.], 2008.

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37

O'Toole, Alison. "Tumour Necrosis Factor-#alpha# signalling : potential roles in the pathophysiology of multiple organ failure." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364934.

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38

Flament, Héloïse. "Modélisation de la réponse anti-tumorale des lymphocytes T CD4+ à l’aide 1) d’une tumeur transplantée exprimant un antigène de manière inductible et 2) de souris porteuses de tumeurs «spontanées»." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T031.

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Le rôle des lymphocytes T CD4+ dans la progression des tumeurs et dans l'immunité anti-tumorale est de plus en plus reconnu chez l'homme et chez la souris. Les mécanismes effecteurs de l’immunité T CD4+ contre le cancer ont été étudiés principalement dans des systèmes de tumeurs transplantées. Dans ces modèles, de nombreuses cellules tumorales meurent au moment de l'implantation, ce qui conduit à la libération de l'antigène tumoral (Ag) dans un contexte inflammatoire. Ceci contraste avec la croissance lente et non-destructrice des tumeurs humaines aux stades précoces. Nous avons montré que la

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39

Veerasubramanian, Priya. "HLA allogene expression in multiple myeloma cells : possible use as anti-tumor vaccine." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33037.

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Multiple myeloma (MM) is a plasma cell malignancy with a high mortality rate. The current treatment options may prolong survival but none of them are curative. Allogeneic gene therapy is a novel vaccine strategy that can augment anti-tumor immune responses and cause remission in some non-hematologic cancers. Immunogene transfer has been successfully performed in human and murine myeloma cells using viral vectors. We used immuno-magnetic negative selection to purify myeloma cells from bone marrow (BM) specimens. We investigated the possibility of in vitro culture of bone marrow mononuclear cell

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40

Clever, David C. Clever. "T Cell-Intrinsic PHD Proteins Regulate Pulmonary Immunity." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471868519.

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41

Vahlne, Gustaf. "Natural killer cell inhibitory and activating receptors : regulatory role in effector functions against normal and tumor cells /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-430-3/.

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42

Wrightham, M. N. "Immunotherapeutic approaches to B cell neoplasms using monoclonal anti-idiotypes and cellular effector mechanisms." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383269.

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43

Raitano, Arthur Bartholomew. "Reciprocal modulation of tumor necrosis factor and gamma interferon receptors in human carcinoma cells: Biological significance and mechanisms of action." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185483.

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Human recombinant cytokines may have a role in the clinical treatment of pancreatic and colorectal cancers. In the present studies, the growth inhibitory actions of recombinant human tumor necrosis factor (rhTNF) and recombinant human gamma interferon (rhIFN-γ) were examined in several human pancreatic and colorectal carcinoma cell lines in vitro in relation to the expression TNF and IFN-γ receptors. rhTNF and rhIFN-γ exerted significant, but differential, growth inhibitory effects in five of six cell lines examined. All six cell lines exhibited high affinity binding sites for both ¹²⁵I-labele

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44

Ruth, Nicola Dawn. "Capturing T-cell receptors : a potential new modality for targeting hepatic tumours and post-transplantational lymphoproliferative disease (PLTD)." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8533/.

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This project sought to identify paediatric tumour-specific phosphopeptide antigens on Post-transplantation lymphoproliferative disease samples (PTLD) and hepatic tumour samples. Tumour-specific T-cells are difficult to maintain in long-term culture, therefore the secondary aim of this project was exploring modalities for capturing T-cell receptor (TCR), important in recognising tumour-specific antigens. This may result in a tumour-specific product. Potential modalities included T-cell hybridomas and Human Induced Pluripotent Stem Cell (hIPSc) technology to immortalise tumour specific T-cells.

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Lo, Jennifer Alys. "Regulation of the Inflamed Tumor Phenotype in Melanoma Immunotherapy." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493467.

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Immune checkpoint inhibitors targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) pathways can deliver durable anti-tumor effects. However, a major fraction of metastatic cancer patients fail to respond to checkpoint blockade. Recent studies suggest that efficacy of checkpoint inhibitors is associated with inflammation in the tumor microenvironment. In this thesis, I demonstrate using genetically-defined murine models that sterile melanomas can be converted into inflamed tumors with improved responses to checkpoint blockade via two independent app

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46

Elkovich, Andrea J. "The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5792.

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Myeloid Derived Suppressor Cells (MDSC) represent a significant hurdle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous studies have reported on the myelo-depletive effects of certain chemotherapies. Using guadecitabine, a next-generation DNA methyltransferase inhibitor (DNMTi), we observed significantly reduced tumor burden in the 4T1 murine mammary carcinoma model. Guadecitabine treatment prevents excessive tumor-induced myeloid proliferation and systemic accumulation, and skews remaining MDSCs toward a beneficial antigen-presenting phenotype. Toget

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Dempster, Holly. "Characterization of the Anti-Tumour Immune Response Following Treatment with an Infected Leukemia Cell Vaccine." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37165.

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Current treatment methods for Acute Leukemia (AL) only provide temporary therapeutic efficacy as most patients will experience relapse within 2 years following first remission. Our lab has determined that vaccination with autologous cells infected with oncolytic virus MG1 can provide durable cures in a pre-clinical mouse model of AL. However, the mechanism(s) by which the infected cell vaccine (ICV) stimulates T cell dependent anti-tumour immunity and provides protection against tumour growth is unknown. This thesis was aimed to determine 1) what antigen presenting cell populations are activat

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48

Rosean, Timothy Robert. "The tumor microenvironment is critical for the development of plasma cell neoplasia in mice." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1497.

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Plasma cell neoplasms (PCN), including multiple myeloma, are tumors of terminally differentiated B cells. Despite a significant research effort, and numerous advances in therapy, most tumors of this B cell lineage remain incurable. To this end, understanding factors which are critical for the development of PCN may lead to new avenues for therapy. Interleukin-6 (IL-6) is a pleiotropic, pro-inflammatory cytokine which supports the growth, proliferation, and survival of myeloma cells. We found that inflammation, and in particular, IL-6 is critical for the development of PCN. In order to determin

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49

Muccioli, Maria. "Characterizing dsRNA-induced inflammation in ovarian cancer cells." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1405707670.

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Nandigam, Harika. "Capability of the Tumor Microenvironment to Attract a Precursor of B-cells and Dendritic Cells from Bone Marrow." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1307108043.

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