Relevant bibliographies by topics / Immunological aspects

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Immunological aspects'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Immunological aspects"

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Fauchère, Jean-Louis, and Leif P. Andersen. "Immunological aspects." Current Opinion in Gastroenterology 11 (1995): 21–24. http://dx.doi.org/10.1097/00001574-199501001-00005.

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Engstrand, Lars, and J. Dominique de Korwin. "Immunological aspects." Current Opinion in Gastroenterology 12 (January 1996): 21–23. http://dx.doi.org/10.1097/00001574-199601001-00005.

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Adebajo, Adewale O., and David A. Isenberg. "Immunological aspects." Baillière's Clinical Rheumatology 9, no. 1 (February 1995): 215–29. http://dx.doi.org/10.1016/s0950-3579(05)80157-8.

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Heyworth, Martin F. "Immunological aspects ofGiardiainfections." Parasite 21 (2014): 55. http://dx.doi.org/10.1051/parasite/2014056.

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Overeem, Sebastiaan, John Logan Black, and Gert Jan Lammers. "Narcolepsy: Immunological aspects." Sleep Medicine Reviews 12, no. 2 (April 2008): 95–107. http://dx.doi.org/10.1016/j.smrv.2007.07.010.

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Grogan, Laura F., Josephine E. Humphries, Jacques Robert, Chantal M. Lanctôt, Catherine J. Nock, David A. Newell, and Hamish I. McCallum. "Immunological Aspects of Chytridiomycosis." Journal of Fungi 6, no. 4 (October 19, 2020): 234. http://dx.doi.org/10.3390/jof6040234.

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Amphibians are currently the most threatened vertebrate class, with the disease chytridiomycosis being a major contributor to their global declines. Chytridiomycosis is a frequently fatal skin disease caused by the fungal pathogens Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal). The severity and extent of the impact of the infection caused by these pathogens across modern Amphibia are unprecedented in the history of vertebrate infectious diseases. The immune system of amphibians is thought to be largely similar to that of other jawed vertebrates, such as mammals. However, amphibian hosts are both ectothermic and water-dependent, which are characteristics favouring fungal proliferation. Although amphibians possess robust constitutive host defences, Bd/Bsal replicate within host cells once these defences have been breached. Intracellular fungal localisation may contribute to evasion of the induced innate immune response. Increasing evidence suggests that once the innate defences are surpassed, fungal virulence factors suppress the targeted adaptive immune responses whilst promoting an ineffectual inflammatory cascade, resulting in immunopathology and systemic metabolic disruption. Thus, although infections are contained within the integument, crucial homeostatic processes become compromised, leading to mortality. In this paper, we present an integrated synthesis of amphibian post-metamorphic immunological responses and the corresponding outcomes of infection with Bd, focusing on recent developments within the field and highlighting future directions.
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Chuhlovina, M. L., and E. A. Bichun. "IMMUNOLOGICAL ASPECTS OF NEUROSYPHILIS." Russian Journal of Infection and Immunity 5, no. 2 (June 28, 2015): 131–36. http://dx.doi.org/10.15789/2220-7619-2015-2-131-136.

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Bender, T. "Immunological aspects of balneology." Boletin Sociedad Española Hidrologia Medica 33, S1 (2018): 67. http://dx.doi.org/10.23853/bsehm.2018.0587.

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Teplen’kiy, M. P., M. V. Chepeleva, and E. I. Kuznetsova. "PERTHES DISEASE: IMMUNOLOGICAL ASPECTS." Russian Clinical Laboratory Diagnostics 65, no. 4 (April 15, 2020): 239–43. http://dx.doi.org/10.18821/0869-2084-2020-65-4-239-243.

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Considering a stage of the pathological process patients (boys at the age of 8-12 years) were divided into two (2) groups. Group I included 14 patients with the fragmentation stage (Perthes disease Stage II). Group 2 included 15 children with Perthes disease Stage III (the stage of re-ossification). Perthes disease regardless of the stage of the disease was characterized by the increase in oxygen-dependent and lysosomal phagocytic activity of neutrophils, the increase in the number of early extracellular traps, as well as by increased concentrations of pro-inflammatory cytokines (IL-1β and TNFa), IgE, decreased concentrations of IL-18. The fragmentation stage was characterized by moderate activation of cellular immunity with a prevailing increase in the number of T-lymphocytes with early activation markers (CD25). At the re-ossification stage the predominance of T-lymphocytes was observed with late activation markers (HLADR), being accompanied by moderate activation of humoral immunity (increased concentrations of class A and G serum immunoglobulins). The obtained data can be used as additional criteria for clarifying Perthes disease stage, predicting osteonecrosis development when making decision of the feasibility of performing reconstructive surgeries on the joint.
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Scheithauer, Heike, Claus Belka, Kirsten Lauber, and Udo S. Gaipl. "Immunological aspects of radiotherapy." Radiation Oncology 9, no. 1 (2014): 185. http://dx.doi.org/10.1186/1748-717x-9-185.

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Dissertations / Theses on the topic "Immunological aspects"

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Ramshaw, Anna Louise. "Immunological aspects of human atherosclerosis." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305549.

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Havranek, Erik Georg Ulrich. "Immunological aspects of renal cancer." Thesis, St George's, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430426.

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Porter, S. R. "Immunological aspects of rapidly progressive periodontitis." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377350.

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Kong, Wai-kwan Wendy, and 江慧君. "The effects of immune activation in the pathogenesis of neurodevelopmental disorders : in vivo and in vitro animal studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/197539.

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Schizophrenia and autism are psychiatric disorders with a presumed neurodevelopmental origin, characterised by clinical features and aetiologies that overlap at multiple levels. In addition to genetic susceptibility, epidemiological studies revealed an association between environmental factors and these disorders. Immune activation in response to infection at early gestation has been identified as one of the key risk factors. Little is known about the underlying mechanism during maternal immune activation (MIA), but extrinsic apoptotic dysregulation has been postulated to play a role in MIA infection. In particular, emerging studies suggest apoptosis without triggering whole cell demise, namely synaptic apoptosis, is a potential event that leads to the abnormal behaviours in the affected offspring. In this study, C57BL/6N mice model was employed to investigate the impacts of viral mimetic polyriboinosinic-polyribocytidylic acid (Poly I:C) exposure at gestation day 9 in the resultant male offspring in adulthood in vivo by different parameters, including magnetic resonance imaging (MRI), behavioural tasks that assess sensorimotor gating, exploratory and anxiety behaviours, and protein quantification in the apoptotic pathway. In parallel, the direct effect of Poly (I:C) treatment for 24 hours on extrinsic apoptotic proteins were determined in primary cortical neurons in vitro. It was hypothesised that MIA would result in brain volumetric changes subsequent to behavioural anomalies in the adult offspring with maternal exposure to Poly (I:C), for which abnormalities are normally pronounced by that time. In addition, the hypothesis that foetuses exposed to Poly (I:C) in early gestation stage would have increased expression level of apoptotic proteins of extrinsic types, namely Fas receptor, caspase-8 and the death effector caspase-3. This study found that, although male adult offspring with early maternal exposure to Poly (I:C) had an increase in raw whole brain volume, this was not significant when body weight was included as a covariable. However, prenatal exposure caused behavioural features similar to those reported in schizophrenia and autism such as prepulse inhibition deficits, increased anxiety-level and higher locomotor activity in response to amphetamine challenge. On the other hand, a marked augmentation in caspase-8 level without any significant changes in Fas or caspase-3 was observed in the adult hippocampus. No alterations in the expression of selected apoptotic proteins were found in the embryonic cortical cells. Overall the present studies suggested that acute exposure to infection during early fetal development causes a range of aberrations in brain anatomy, behaviour and biochemistry that are of relevance to the pathophysiology of schizophrenia and autism. The results suggest a potential involvement of synaptic apoptosis in cellular events underlying neurodevelopmental disorders.
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Psychiatry
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Neumann, Andersen Grethe. "Systemic sclerosis : vascular, pulmonary and immunological aspects." Doctoral thesis, Umeå universitet, Reumatologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1806.

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In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. Moreover, to characterize the role of nitric oxide (NO) in vascular engagement. Peripheral arterial changes cause Raynaud’s phenomenon and digital ulcers. Nitric oxide (NO) a main inducer of vasodilation is produced by endothelial nitric oxide synthase (eNOS) in response to changes in blood flow or by inflammatory cytokine inducible (i) NOS. In the vascular smooth muscle cell (VSMC) NO activates guanylate cyclase to produce cGMP, causing relaxation. We showed elevated plasma nitrate, a degradation product of NO, and increased urinary excretion of nitrate and cGMP. Plasma nitrate correlated with elevated levels of endothelial adhesion molecules: endothelial (E) selectin and vascular adhesion molecule 1, indicating that the activated endothelium is the site of NO synthesis by iNOS. Endothelial staining for E-selectin and the finding of iNOS and eNOS in SSc skin biopsies supported this notion. In SSc increased vascular stiffness may limit the NO vasodilatory effects. We found normal endothelium-dependent (i.e. flow mediated (FMD%)) and endothelium-independent (i.e. nitroglycerin-induced (NTG%)) vasodilation in the brachial artery. Radial arterial wall stiffness measured as maximum increase in pulse pressure (dP/dtmax) was increased. FMD% and especially NTG% correlated negatively and dP/dtmax positively to measures of endothelial inflammation: plasma- nitrate and adhesion molecule levels. Thus inflammatory vascular wall changes may interfere with dilation as may the presence of nitrate tolerance. We found elevated alveolar MMP-9 in both its pro- and active form in ILD. The levels correlated to decline in lung capacity, pointing at a causal relation. We suggest that neutrophils secrete MMP-9, which may degrade collagen IV, (the main constituent of basal membranes), collagen V, gelatins, proteoglycans and elastin. MMP-9 activity is partly regulated by the binding of pro- and active form to TIMP-1. Alveolar TIMP-1, which even stimulates fibroblast ECM synthesis, was increased independent of ILD. The inflammatory process in ILD is orchestrated by activated T helper (h) lymphocytes. We found a mixed Th1/Th2 reaction in SSc alveolar T cells expressing messenger for interferon gamma (Th1), IL-6 and IL-10 (both Th2). No particular cytokine mRNA profile distinguished alveolar T cells in ILD. Neutrophils invaded the bronchial epithelium, which seemed otherwise inert as levels of inflammatory cytokine sensitive transcription factors and their nuclear translocation tended to be low. The neutrophil recruitment pathway is uncertain as chemoattractants and endothelial adhesion molecules were normally expressed. In conclusion, MMP-9 probably causes degradation of lung tissue in ILD and may represent a future therapeutic target. Alveolar T cells show a mixed Th1/Th2 cytokine profile independent of ILD. Neutrophils invade the bronchial epithelium. Activated endothelium produces increased amounts of NO and adhesion molecules and the level of activation influences brachial arterial FMD% and NTG% and radial arterial compliance. Nitrate tolerance may be present.
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Sjöwall, Johanna. "Clinical and Immunological Aspects of Lyme borreliosis." Doctoral thesis, Linköpings universitet, Infektionsmedicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68745.

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Lyme borreliosis (LB) is a tick-borne infection caused by spirochetes of the Borrelia (B.) burgdorferi sensu lato complex. The infection is associated with several clinical features, of which erythema migrans (EM) and neuroborreliosis (NB) are the most common in Europe. The prognosis after antibiotic therapy is generally good. However, some patients may have residual symptoms post-treatment. The cause of the delayed convalescence is unclear. There are several factors that may affect the clinical outcome of LB, for example, the early interaction between the host’s immune response and B. burgdorferi, the spirochete genotype, antibiotic therapy, as well as the host’s vulnerability. This thesis aimed to explore the type of early immune response that is generated to B. burgdorferi and its importance for the clinical outcome of LB, and to study the condition of persistent symptoms post-NB from clinical, immunological and diagnostic perspectives. In total, 125 adult patients with different clinical features and outcomes of LB and 23 healthy controls were included. In a prospective follow-up study of EM, we confirmed that the prognosis of EM is good after antibiotic therapy, and that B. afzelii is the most common B. burgdorferi genotype associated with EM in the Nordic countries. Seven patients (8%) reported persistent symptoms more than six months post-treatment. These patients had also a decreased early expression of inflammatory, Th1-type cytokines in the EM lesions, suggesting an importance of early, local Th1-type immunity to B. burgdorferi for a successful clinical outcome of LB. No correlation between clinical characteristics, allergic predisposition, B. burgdorferi genotype or serology and the development of symptoms post-treatment was found. Asymptomatic B. burgdorferi-seropositive individuals are interesting from clinical and immunological points of view, since they apparently have encountered B. burgdorferi without developing symptoms of LB. In this thesis, asymptomatic individuals were shown to display an enhanced innate inflammatory immune response to live B. garinii spirochetes, induced by dendritic cells and whole blood cells, in comparison with patients with a history of subacute NB and healthy controls. Whether this is the optimal immune response to B. burgdorferi remains to be determined. A randomized, placebo-controlled cross-over study showed that three weeks of doxycycline therapy did not significantly improve objective neurological signs, subjective symptoms or quality of life in NB patients with persistent symptoms post-treatment. Nor could any doxycycline-mediated effects on systemic cytokine responses be demonstrated. Brain magnetic resonance imaging (MRI) findings in NB patients with persistent symptoms post-treatment were shown to be nonspecific and to correlate with age, but not with the duration of symptoms. In conclusion, this thesis shows that there is an association between the early immune response to B. burgdorferi sensu lato and the clinical outcome of LB. The cause of prolonged convalescence post-treatment remains unknown and needs further investigation. However, repeated treatment with doxycycline does not lead to improvement of the persistent symptoms; nor does brain MRI facilitate diagnosis of, or provide an explanation for the post-treatment symptoms.
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Wood, Matthew John Andrew. "Immunological aspects of neural transplantation in rodents." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333298.

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Calvet, Christophe. "Immunological aspects of anticancer electroporation-based treatments." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114816.

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L'électrochimiothérapie est un traitement anticancéreux utilisé en routine en Europe dans près de 130 centres de traitement du cancer. Le taux de réponse objective atteint 85 % pour le traitment de tumeurs cutanées et sous-cutanées et des études sont en cours afin d'appliquer ce traitement à des tumeurs profondes. Au cours de ce doctorat, les méchanismes sous-jacents à cette excellente efficacité antitumorale ont été étudiés. Dans un premier temps, l'objectif a été d'évaluer la capacité de l'électrochimiothérapie à induire la mort des cellules souches cancéreuses, considérées comme les racines du cancer. Ensuite, les mécanismes immunologiques à l'origine du développement d'une immunité antitumorale mise en place par le traitement ont été investigués. Cependant, malgré le haut taux de réponse observé, l'électrochimiothérapie reste un traitement local qui n'induit pas de réponse antitumorale à distance, sur les tumeurs non-traitées. Afin de pallier à cette absence d'activité systémique, une collaboration a été mise en place avec une entreprise innovante de biotechnologies, INVECTYS, dans le but de développer une stratégie de vaccination à ADN ciblant la télomérase et basée sur l'électrogènetransfert. Il est attendu que la combinaison de cette immunothérapie avec un traitement local par électrochimiothérapie, détruise non seulement la tumeur primaire, dont les cellules souches cancéreuses, mais également les cellules cancéreuses circulantes et les métastases
Electrochemotherapy is an anticancer treatment used in routine in Europe in 130 cancer treatment centers. The objective response rate reaches 85 % for the treatment of cutaneous and subcutaneous tumors and studies are ongoing to spread the use of electrochemotherapy to deep-seated tumors. In the frame of this doctorate, the mechanisms underlying this excellent antitumor efficiency were investigated. First, the goal was to evaluate the ability of electrochemotherapy to induce the death of cancer stem cells, considered as the roots of cancer. Second, the immunological mechanisms responsible for the development of antitumor immune responses following the treatment were investigated. However, although a very high response rate is observed, electrochemotherapy remains a local treatment which does not induce antitumor responses in distant non-treated nodules. In order to circumvent this lack of systemic activity, a collaborative project was initiated with an innovating biotech company, INVECTYS, in order to develop a DNA vaccination strategy targeting the telomerase and based on electrogenetransfer. It is expected that the combination of this immunotherapy with a local treatment by electrochemotherapy could destroy not only the primary tumor, including cancer stem cells, but also circulating cancer cells and metastases
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Makarenko, O., O. Molozhava, Тетяна Василівна Івахнюк, Татьяна Васильевна Ивахнюк, Tetiana Vasylivna Ivakhniuk, I. Wolfe, and R. Broz. "Microbiological and immunological aspects of Alzheimer's disease." Thesis, OMICS International Pvt Ltd, 2017. https://essuir.sumdu.edu.ua/handle/123456789/81108.

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В роботі описані результати мікробіологічних та імунологічних показників пацієнтів з хворобою Альцгеймера.
В работе описаны результаты микробиологических и иммунологических показателей пациентов с болезнью Альцгеймера.
The paper describes the results of microbiological and immunological parameters of patients with Alzheimer's disease.
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Franks, Susan F. (Susan Faye). "Negative Psychological States: Predictors for Immunological Health." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc332521/.

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Relationships of negative psychological conditions with general status of cell-mediated and humoral immune systems were investigated. A unique approach was utilized in that indexes representing multiple aspects of each branch of the immune system were employed to better indicate general immunological status. Differences in emotion-immune interactions between males and females were demonstrated. Results indicated a positive relationship between Trait Anger and Cell-Mediated Immunological Index. Particular criticisms of previous psychoneuroimmunological research were met by addressing sex differences and differences in various conditions of anger and depression, as well as through assessment of cumulative effects of negative emotions on immune system status. Directions for future research in eddressing similar issues are suggested. In general, results provide support for validity of mindbody interactionism and imply the need for revision of standard medical and psychological treatment.
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Books on the topic "Immunological aspects"

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Harris, J. R., ed. Immunological Aspects. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-1681-5.

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R, Harris James, ed. Immunological aspects. New York: Plenum Press, 1988.

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Hancock, B. W., and A. Milford Ward, eds. Immunological Aspects of Cancer. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2557-4.

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Mahida, Y. R., ed. Immunological Aspects of Gastroenterology. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0790-0.

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R, Mahida Y., ed. Immunological aspects of gastroenterology. Dordrecht: Kluwer Academic Publishers, 2001.

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Chaudry, Irshad H. Immunological aspects of hemorrhage. Austin: R.G. Landes, 1992.

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name, No. Immunological aspects of gastroenterology. Dordrecht: Kluwer Academic Publishers, 2003.

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W, Hancock Barry, and Ward A. Milford, eds. Immunological aspects of cancer. Boston: Nijhoff, 1985.

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Ivanyi, L., ed. Immunological Aspects of Oral Diseases. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4167-0.

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Björkland, Anna. Primary biliary cirrhosis: Immunological aspects. Uppsala: Uppsala University, 1994.

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Book chapters on the topic "Immunological aspects"

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Miller, K., and S. Nicklin. "Immunological Aspects." In The Future of Predictive Safety Evaluation, 181–94. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4139-7_14.

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Lawler, Sylvia D., and Rosemary A. Fisher. "Immunological Aspects." In Clinical Perspectives in Obstetrics and Gynecology, 77–87. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4612-4698-5_7.

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Westra, A. L., and J. Prop. "Immunological Aspects." In The Transplantation and Replacement of Thoracic Organs, 307–14. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0711-9_39.

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Scheynius, Annika. "Immunological Aspects." In Allergic Contact Dermatitis, 4–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80331-4_2.

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Baker, Rodney C., and Thomas R. Jerrells. "Immunological Aspects." In Recent Developments in Alcoholism, 249–71. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1742-3_15.

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Siriwardana, Yamuna Deepani. "Immunological Aspects." In Leishmaniasis in Sri Lanka, 65–71. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003281801-9.

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Saji, Fumitaka, Yoshihiro Samejima, Shoji Kamiura, Koichiro Shimoya, Masayasu Koyama, and Tadashi Kimura. "Immunological Aspects of Chorioamnionitis." In Reproductive Immunology, 387–94. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4197-0_40.

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Barret, Juan P., and Veronica Tomasello. "Immunological Aspects and Immunomodulation." In Face Transplantation, 91–101. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-45444-2_11.

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Lauthier, Juan José, and Masataka Korenaga. "Immunological and Immunopathological Aspects." In The Leishmaniases: Old Neglected Tropical Diseases, 107–25. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72386-0_5.

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Green, H. N. "Immunological Aspects of Cancer." In Ciba Foundation Symposium - Carcinogenesis: Mechanisms of Action, 131–64. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470719138.ch12.

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Conference papers on the topic "Immunological aspects"

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Polyvanov, Yehor. "IMMUNOLOGICAL ASPECTS OF PHYSICAL CULTURE AND TREATMENT-PREVENTIVE NUTRITION." In PUBLIC COMMUNICATION IN SCIENCE: PHILOSOPHICAL, CULTURAL, POLITICAL, ECONOMIC AND IT CONTEXT, chair Oleksii Horpynych and Nataliia Kondratiuk. European Scientific Platform, 2020. http://dx.doi.org/10.36074/15.05.2020.v5.30.

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Trushina, Eleonora, Oksana Mustafina, and Nikolay Riger. "Immunological aspects of the use of L-carnitine in sports nutrition." In Proceedings of the 4th International Conference on Innovations in Sports, Tourism and Instructional Science (ICISTIS 2019). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/icistis-19.2019.73.

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Salem, T. Ben, M. Tougorti, I. Naceur, I. Ben Ghorbel, M. Lamloum, and MH Houman. "THU0291 Gender influence on clinical, biological and immunological aspects of systemic lupus erythematosus." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.2323.

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Khatkhe, Yulia, Anna Ivanisova, Natalia Zabolotskikh, and Uliana Koshkina. "CLINICAL, EPIDEMIOLOGICAL AND IMMUNOLOGICAL ASPECTS OF MYASTHENIA GRAVIS AMONG ADULTS IN THE KRASNODAR REGION." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2382.sudak.ns2021-17/403.

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Ovcharenko, Yevgeniya, Valeriy Erichev, Tatyana Aksenova, and Nina Bagdasaryan. "IMMUNOLOGICAL AND MICROBIOLOGICAL ASPECTS OF THE EFFECTIVENESS OF ORAL HYGIENE FOR PATIENTS WITH PERIODONTAL INFLAMMATORY DISEASES." In RAD Conference. RAD Association, 2017. http://dx.doi.org/10.21175/radproc.2017.46.

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Ali SAEED, Eiman. "COVID-19 : A RETROSPECTIVE MINI REVIEW ON THE PANDEMIC VIRUS, IMMUNOLOGICAL ASPECTS AND BACTERIAL CO-INFECTIONS." In VI.International Scientific Congress of Pure,Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress6-41.

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In 2019 the Corona pandemic spread in Wuhan City, Hubei, China. It is a disease officially known as "coronavirus disease 2019; COVID-19", which is the pathogen of respiratory tract infection and its genome sequence have been fully identified. The genetic sequence of COVID-19 showed a similar but distinct genome content for both SARS-CoV and MERS-CoV. Clinical evidence and genetics point to the course of this pandemic. Open access data and genomic sequencing combined with the development of a specialized vaccine against infection with this virus, it will give us additional information about what this virus is, the nature of the immune response generated against it and plan for the herd immunity by vaccination. In current study, we review the role of innate and acquired immunity against COVID-19 and how it works in the host's body. Then, talk about herd immunity and how can reach it to protect the population from this virus. Also, focused in this review on associated bacterial infections with viral respiratory infections.
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Silva, Tarcisio Rubens da, Marina Monteiro Navarro, Mylena Mendes Hóstio, and Catherine Sonaly Ferreira Martins. "Case report - Ataxia-telangiectasia: innate error of immunity and neurological aspects." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.233.

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Introduction: Among more than 350 immunological deficiencies, 25% have neurological manifestations. Thus, Ataxia-telangiectasia stands out, being considered a combined immunodeficiency. In childhood, cerebellar motor findings and recurrent sinopulmonary infections, signaling early cerebellar degeneration and deficit in the combined immune response. It has an autosomal recessive inheritance pattern. Case report: She describes herself as a female patient, 9 years old, daughter of consanguineous parents and born in Sousa, Paraíba. In the child’s neuropsychomotor development, she sat down at 5 months, verbalized loose words at 12 months and started the process of ambulation at 13 months of life. While walking, the mother noticed strange walking and frequent hospitalizations due to recurrent pneumonia. From 7 years of age, there is worsening of gait and telangiectasias in the conjunctiva are evident. Subsequently, the molecular examination in order to demonstrate the possible mutation. Therefore, a mutation described as c.7913G> A (p.Trp2638 *) was found in homozygosity in exon 53 of the ATM gene. Findings: typical onset of early childhood when walking, swallowing problems with solid and liquid foods and the growth disorder. Regarding the immune system: low levels of immunoglobulins, but without lymphopenia and the worrying presence of adenomegaly, making it necessary to always pay attention to neoplasms such as leukemias and lymphomas. In disagreement, there are no: myoclonus, the highest IgM levels, cutaneous granulomas and bone deformities. Conclusions: The case presents aspects that are very consistent with the scientific findings consolidated in Ataxia-telangiectasia, but the late molecular diagnosis.
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Leshkova, I. V., O. V. Dolgih, and O. YU Ustinova. "IMMUNOLOGICAL DISORDERS OF THE REPRODUCTIVE SYSTEM THAT OCCUR WHEN EXPOSED TO BENZENE, IN EMPLOYEES OF OIL-PRODUCING ENTERPRISES." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-313-316.

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Abstract. Introduction. The protection of the reproductive health of the working-age population is the most important direction of State policy. In 5-15% of cases, the causes of reproductive dysfunction are immunological disorders. Benzene belongs to the group of industrial reprotoxicants, however, its effect of benzene on the reproductive system has not been sufficiently studied. Objective: to study the immunological aspects of the effect of benzene on the reproductive system. Methods. We examined 50 men exposed to benzene with reproductive disorders (26-49 years old), as well as 4 workers with normal sexual function aged 53-60 years. Spontaneous and induced changes in the cellular expression of apoptosis markers were studied. For the study, the ANNEXIN V-FITC/7-AAD kit was used for the detection of cells that have undergone apoptosis. The experiment was conducted in vitro using a biological medium (ejaculate). A factor of the chemical nature was benzene. Results. According to the results of the comparative analysis, there were no significant deviations of pathogenetic tests of immunological markers in comparison with the reference level in the spontaneous expression samples, but there was an excess of expression of the CD95 + cell death receptor (p<0.05) in 30% of the samples examined, and a decrease in the number of Annexin V-FITC+7AAD negative cells (without reaching the significance level) in samples with a load of (15%). There was a difference in the expression levels of CD95+ and CD25+ CD-reception indicators by 20% and 10% in relation to the spontaneous level (p<0.05). Representatives of the chemical group of aromatic hydrocarbons realize reprotoxicity, using the mechanism of excessive induction of the membrane signaling of the cell death receptor, accelerate the natural program of cell death by approximately 20% compared to the state of reproductive cells that were not stimulated. Conclusion. At the present stage, one of the tasks of occupational medicine is to study the effect of chemicals on the processes of reproduction, to develop new approaches to assessing the risk of their impact on the reproductive health of workers.
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Cabral, Brenda Cristyanne Silva, Isabela Cristina Maioni Xavier, Giovana Souza Oliveira, Jade Fleury Toccafondo, Maria Carolina Boeira Keller, Bárbara Natiely Bezerra Andrade, Caroline Gomes dos Santos, et al. "Relationship between the dimensions of eating behavior and weight gain in high-risk pregnant women monitored at a university hospital." In V Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvmulti2024-158.

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During the gestational period, several physiological adaptations occur in the woman's body to meet the demands of the maternal-fetal binomial and childbirth. These changes encompass anatomical, hormonal, metabolic and immunological aspects, varying according to gestational age. After confirmation of pregnancy, it is essential that the woman begins prenatal care in Basic Health Units (UBS), although cases of risk factors may require follow-up in highly complex hospitals. Several factors, such as individual characteristics, previous and obstetric conditions, can make a pregnancy high-risk, requiring lifestyle changes and professional support to avoid adverse outcomes. Inadequate weight gain during pregnancy is one of these factors, associated with complications such as gestational diabetes, high blood pressure and childhood obesity. The prevalence of overweight and obesity among pregnant women has increased, highlighting the importance of adequate monitoring during pregnancy for maternal and fetal health.
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Hamid, Fatima FH, Scott Schactler, Debra Walter, Hardik Amin, Minh Le, David Burkhart, Chenming Zhang, and Marco Pravetoni. "Deciphering immunological mechanisms underlying the efficacy of nanoparticle-based vaccines and novel adjuvants against Opioid Use Disorder (OUD)." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.283050.

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Reports on the topic "Immunological aspects"

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Alarcón-Sánchez, Mario Alberto, Giuseppe Minervini, and Artak Heboyan. Clinical and immunological aspects of gingival retraction systems in fixed dental prostheses: A systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2024. http://dx.doi.org/10.37766/inplasy2024.1.0005.

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Eldar, Avigdor, and Donald L. Evans. Streptococcus iniae Infections in Trout and Tilapia: Host-Pathogen Interactions, the Immune Response Toward the Pathogen and Vaccine Formulation. United States Department of Agriculture, December 2000. http://dx.doi.org/10.32747/2000.7575286.bard.

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In Israel and in the U.S., Streptococcus iniae is responsible for considerable losses in various fish species. Poor understanding of its virulence factors and limited know-how-to of vaccine formulation and administration are the main reasons for the limited efficacy of vaccines. Our strategy was that in order to Improve control measures, both aspects should be equally addressed. Our proposal included the following objectives: (i) construction of host-pathogen interaction models; (ii) characterization of virulence factors and immunodominant antigens, with assessment of their relative importance in terms of protection and (iii) genetic identification of virulence factors and genes, with evaluation of the protective effect of recombinant proteins. We have shown that two different serotypes are involved. Their capsular polysaccharides (CPS) were characterized, and proved to play an important role in immune evasion and in other consequences of the infection. This is an innovative finding in fish bacteriology and resembles what, in other fields, has become apparent in the recent years: S. iniae alters surface antigens. By so doing, the pathogen escapes immune destruction. Immunological assays (agar-gel immunodiffusion and antibody titers) confirmed that only limited cross recognition between the two types occurs and that capsular polysaccharides are immunodominant. Vaccination with purified CPS (as an acellular vaccine) results in protection. In vitro and ex-vivo models have allowed us to unravel additional insights of the host-pathogen interactions. S. iniae 173 (type II) produced DNA fragmentation of TMB-8 cells characteristic of cellular necrosis; the same isolate also prevented the development of apoptosis in NCC. This was determined by finding reduced expression of phosphotidylserine (PS) on the outer membrane leaflet of NCC. NCC treated with this isolate had very high levels of cellular necrosis compared to all other isolates. This cellular pathology was confirmed by observing reduced DNA laddering in these same treated cells. Transmission EM also showed characteristic necrotic cellular changes in treated cells. To determine if the (in vitro) PCD/apoptosis protective effects of #173 correlated with any in vivo activity, tilapia were injected IV with #173 and #164 (an Israeli type I strain). Following injection, purified NCC were tested (in vitro) for cytotoxicity against HL-60 target cells. Four significant observations were made : (i) fish injected with #173 had 100-400% increased cytotoxicity compared to #164 (ii) in vivo activation occurred within 5 minutes of injection; (iii) activation occurred only within the peripheral blood compartment; and (iv) the isolate that protected NCC from apoptosis in vitro caused in vivo activation of cytotoxicity. The levels of in vivo cytotoxicity responses are associated with certain pathogens (pathogen associated molecular patterns/PAMP) and with the tissue of origin of NCC. NCC from different tissue (i.e. PBL, anterior kidney, spleen) exist in different states of differentiation. Random amplified polymorphic DNA (RAPD) analysis revealed the "adaptation" of the bacterium to the vaccinated environment, suggesting a "Darwinian-like" evolution of any bacterium. Due to the selective pressure which has occurred in the vaccinated environment, type II strains, able to evade the protective response elicited by the vaccine, have evolved from type I strains. The increased virulence through the appropriation of a novel antigenic composition conforms with pathogenic mechanisms described for other streptococci. Vaccine efficacy was improved: water-in-oil formulations were found effective in inducing protection that lasted for a period of (at least) 6 months. Protection was evaluated by functional tests - the protective effect, and immunological parameters - elicitation of T- and B-cells proliferation. Vaccinated fish were found to be resistant to the disease for (at least) six months; protection was accompanied by activation of the cellular and the humoral branches.
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