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Journal articles on the topic 'Immunolog'

Author: Grafiati

Published: 29 July 2024

Last updated: 30 July 2024

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1

CASTA??EDA-ZARATE, S., E. GARCIAPROCEL, M. LOURDES-IRIGOYEN, and L. P??REZ-TAMAYO. "Immunolog??ca del Halotano." Survey of Anesthesiology 29, no. 3 (June 1985): 161???162. http://dx.doi.org/10.1097/00132586-198506000-00017.

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2

Оковитий, Сергій, Наталія Кондратюк, and Єгор Поливанов. "РОЛЬ ГЛЮКУРОНОВОЇ КИСЛОТИ У БІОТРАНСФОРМАЦІЇ КСЕНОБІОТИКІВ: ХІМІЧНІ АСПЕКТИ." European Science, sge15-01 (December 30, 2019): 51–60. http://dx.doi.org/10.30890/2709-2313.2022-15-01-014.

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In the XXI century, the human body began to be exposed to a variety of synthesized substances - xenobiotics. And, as their number is growing, the adaptive forces of the body are not able to provide a timely response. This leads to a decrease in immunolog

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3

Chica, Carmen. "Javier Sebasti�n Mazana Casanova: Historia de la immunolog�a." International Microbiology 6, no. 2 (June 1, 2003): 153–54. http://dx.doi.org/10.1007/s10123-003-0126-z.

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4

Riechelmann, H., C. Bachert, O. Goldschmidt, B. Hauswald, L. Klimek, W. W. Schlenter, A. J. Tasman, and M. Wagenmann. "Durchführung des nasalen Provokationstests bei Erkrankungen der oberen Atemwege – Positionspapier der Deutschen Gesellschaft für Allergologie und Klinische Immunologie (Sektion HNO) gemeinsam mit der Arbeitsgemeinschaft Klinische Immunolog." Allergologie 25, no. 09 (September 1, 2002): 489–96. http://dx.doi.org/10.5414/alp25489.

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5

Ghersetich, I. "Immunologic aspects: Immunology of mineral water spas." Clinics in Dermatology 14, no. 6 (December 1996): 563–66. http://dx.doi.org/10.1016/s0738-081x(96)00085-5.

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6

Hudspith, Barry. "Immunology and immunologic diseases of the lung." Food and Chemical Toxicology 28, no. 6 (January 1990): 457. http://dx.doi.org/10.1016/0278-6915(90)90094-4.

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7

Faling, L. Jack. "Immunology and Immunologic Diseases of the Lung." JAMA: The Journal of the American Medical Association 262, no. 4 (July 28, 1989): 570. http://dx.doi.org/10.1001/jama.1989.03430040142051.

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8

EL Hassouni, Youssef, Mohammed Bourhia, Ahmed Bari, Riaz Ullah, Hafiz Majid Mahmood, Syed Saeed Ali, Samir Ibenmoussa, and Admou Brahim. "Evaluation of the performance of immunoblot and immunodot techniques used to identify autoantibodies in patients with autoimmune diseases." Open Chemistry 19, no. 1 (January 1, 2021): 237–44. http://dx.doi.org/10.1515/chem-2020-0101.

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Abstract Autoimmune diseases are pathological conditions in which the immune system mistakenly attacks its own tissues. This study evaluates the performance of two techniques, which are identifiers of autoantibody specifics: immunoblot and immunodot. This study was conducted in 300 patients of whom 62 were tested positive for antinuclear antibodies. The patients were initially screened for antinuclear antibodies using indirect immunofluorescence. Then, the identification of specific autoantibodies such as anti-extractable nuclear antigens (ENAs) was carried out using the immunoblot and immunodot techniques. The results showed that immunoblot and immunodot did not present a significant difference in their sensitivity against anti-SSA/52, SSB, CENP-B, PCNA, U1-snRNP, Jo-1, Pm-scl, and Mi-2 (p > 0.05). However, the two techniques showed a significant difference in their sensitivity toward autoantibodies anti-DNAn, anti-histone, anti-SmD1, and anti-ds-DNA (p < 0.05). The immunoblot data were in complete accordance with the immunodot data (100%) regarding the detection of autoantibodies such as anti SSA/52, SSB, CENP-B, PCNA, U1-snRP, Jo-1, Pm-scl, and Mi-2, 80% regarding SmD1, and 75% concerning ds-DNA. We should certainly pay closer attention to the efficiency of the techniques used in the diagnosis of autoimmune diseases.

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9

Carbonara, A. "Dammacco F. (Ed.):Immunologia in Medicina (Immunology in Medicine)." La Ricerca in Clinica e in Laboratorio 19, no. 1 (December 1989): 187–88. http://dx.doi.org/10.1007/bf02871808.

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10

Dorian, Barbara, and Paul E. Garfinkel. "Stress, immunity and illness — a review." Psychological Medicine 17, no. 2 (May 1987): 393–407. http://dx.doi.org/10.1017/s0033291700024958.

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SynopsisPsychological factors have long been thought to play a contributing role in either the predisposition, onset or course of various physical illnesses. Recently, rapid advances in immunology have created interest in the interaction between psychosocial factors, behaviour and the immune system. This paper reviews some of the models proposed to explain the relationship between psychological variables and physical illness and presents evidence for a contribution of psychological factors to certain illnesses in which abnormalities in immunologic state are thought to be important. From a somewhat different perspective, animal studies have demonstrated complex effects of stress, on disease susceptibility. Recent human studies have demonstrated consistent immunologic changes in people undergoing acute naturally occurring psychological stress such as bereavement or an important examination. In humans, the effects of chronic stress may be different from acute stress, corresponding to the findings in animals. Abnormalities in immunologic functioning and physical illness are reviewed for different psychiatric disorders — depression, anorexia nervosa and schizophrenia; depression is the only disorder which consistently demonstrated immunologic changes. Possible mechanisms for the stress/immune-change relationship are suggested.

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11

Howard, Donald R., and John G. Batsakis. "Non-Hodgkin's Lymphomas: Contemporary Classification and Correlates." Annals of Otology, Rhinology & Laryngology 94, no. 3 (May 1985): 326–28. http://dx.doi.org/10.1177/000348948509400323.

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Recent advances in immunology have resulted in an entirely new approach to the classification of the non-Hodgkin's lymphomas based on immune function. Previous classifications, still in use today, are based on morphology and although prognostically useful, are imprecise and include diverse disease entities. The present report reviews the evolution of these classifications and emphasizes the prognostic, therapeutic, and conceptual advantages of the functional (immunologic) approach to the study of lymphomas.

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12

Tian, Xinping, Mengtao Li, Shengyun Liu, Xiaomei Leng, Qian Wang, Jiuliang Zhao, Yi Liu, et al. "Consensus on targeted drug therapy for spondyloarthritis." Rheumatology and Immunology Research 4, no. 2 (June 1, 2023): 47–59. http://dx.doi.org/10.2478/rir-2023-0009.

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Abstract Spondyloarthritis (SpA) is a group of chronic inflammatory diseases that predominantly involve the spine and/or peripheral joints. The clinical manifestations of SpA are highly heterogenous and complicated with various comorbidities. SpA is a disabling disease and adversely affects the quality of life of patients. Many new medications that target cytokines or pathways specific for the pathogenesis of SpA have been developed and they are becoming increasingly important in the treatment of SpA. However, identifying the target patient population and standardizing the usage of these drugs are critical issues in the clinical application of these “targeted therapeutic drugs”. Under the leadership of National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), managed by Peking Union Medical College Hospital, the “Consensus on targeted drug therapy for spondyloarthritis” has been developed in collaboration with the Rheumatology and Immunology Physicians Committee, Chinese Medical Doctors Association, Rheumatology and Immunology Professional Committee, Chinese Association of Rehabilitation Medicine, and Chinese Research Hospital Association Rheumatology and Immunology Professional Committee. This consensus has been developed with evidence-based methodology and has followed the international standard for consensus development.

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13

Tamari, Masato, Aaron M. Ver Heul, and Brian S. Kim. "Immunosensation: Neuroimmune Cross Talk in the Skin." Annual Review of Immunology 39, no. 1 (April 26, 2021): 369–93. http://dx.doi.org/10.1146/annurev-immunol-101719-113805.

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Classically, skin was considered a mere structural barrier protecting organisms from a diversity of environmental insults. In recent decades, the cutaneous immune system has become recognized as a complex immunologic barrier involved in both antimicrobial immunity and homeostatic processes like wound healing. To sense a variety of chemical, mechanical, and thermal stimuli, the skin harbors one of the most sophisticated sensory networks in the body. However, recent studies suggest that the cutaneous nervous system is highly integrated with the immune system to encode specific sensations into evolutionarily conserved protective behaviors. In addition to directly sensing pathogens, neurons employ novel neuroimmune mechanisms to provide host immunity. Therefore, given that sensation underlies various physiologies through increasingly complex reflex arcs, a much more dynamic picture is emerging of the skin as a truly systemic organ with highly coordinated physical, immunologic, and neural functions in barrier immunology.

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14

Nayak, Ashok, Sajith Babu S. M., and Lal Mani Singh. "Immunological monitoring of brain tumour patients." International Surgery Journal 5, no. 5 (April 21, 2018): 1681. http://dx.doi.org/10.18203/2349-2902.isj20181422.

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Background: Patient suffering from CNS tumours are among the best suited as regards the study of their immunologic status is concerned because these tumours rarely metastasize and general condition of patient is not much affected. Extensive research has been done on immunological response in neoplasms of other organs, but immunology of CNS tumours studied mainly during last five decades. It is now realized that immunologic reactions may be important in the development and growth of the CNS tumours. Although there is evidence that immunotherapy is helpful in control of some solid tumours but adequate knowledge of the immunology of glial tumours to guide the rational treatment is not yet available. Methods: This study was conducted on 60 cases that included 20 controls and 40 patients of primary intracranial brain tumors admitted to neurosurgical services of University Hospital, Banaras Hindu University, Varanasi during the period of January 1987 to January 1988. Results: The study revealed, medulloblastoma and glioblastoma or anaplastic astrocytoma show more marked suppression of cell mediated immunity than astrocytoma grade +II and other malignant tumour subgroups. In case of humoral immune response, antigen of brain tumours elicit an Ig M response rather IgG response which is commonly elicited in other neoplasia.Conclusions: The results regarding Ig M, and Ig G levels are in agreement with most of the other studies. It appears that antigen of brain tumours elicits an Ig M response rather IgG response which is commonly elicited in other neoplasia.

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15

Agnihotri, Neha T., and Paul A. Greenberger. "Unproved and controversial methods and theories in allergy/immunology." Allergy and Asthma Proceedings 40, no. 6 (November 1, 2019): 490–93. http://dx.doi.org/10.2500/aap.2019.40.4278.

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Unproved methods and controversial theories in the diagnosis and management of allergy/immunology are those that lack scientific credibility. Some definitions are provided for perspective, as in chronic medical conditions, frequently nonscientifically based treatments are developed that can have a profound psychological effect on the patients in the absence of objective physical benefit. Standard practice uses methods of diagnosis and treatment used by reputable physicians in a particular subspecialty or primary care practice, with the understanding that diagnosis and treatment options are consistent with established mechanisms of conditions or diseases. Conventional medicine (Western or allopathic medicine) is that which is practiced by the majority of physicians, osteopaths, psychologists, registered nurses, and physical therapists. Complementary medicine involves diverse practices or products that are used with the practice of conventional medicine, such as using acupuncture in addition to opioids for pain relief. Alternative medicine implies use of complementary practices in place of conventional medicine. Unproved and controversial methods and theories do not have supporting data, validation, or sufficient scientific scrutiny, and they should not be used in the practice of allergy/immunology. Some examples of unproven theories about allergic/immunologic conditions include allergic toxemia, idiopathic environmental intolerance, and toxic disease from indoor molds. Unconventional diagnostic methods for allergic conditions include cytotoxic tests, provocation-neutralization, electrodermal diagnosis, applied kinesiology assessments, chemical analysis of body fluids, and serum immunoglobulin G (IgG) or IgG4 testing. Unproven treatments and intervention methods for allergic/immunologic conditions include acupuncture, homeopathy, halotherapy, and autogenous urine injections.

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16

Bielory, Leonard. "Allergic and immunologic disorders of the eye. Part I: Immunology of the eye." Journal of Allergy and Clinical Immunology 106, no. 5 (November 2000): 805–16. http://dx.doi.org/10.1067/mai.2000.111029.

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17

HUANG, SHIH-WEN. "Immunology of Insulin-Dependent Diabetes Mellitus: A Perspective from Pathogenesis to Immunologic Intervention." Pediatric Asthma, Allergy & Immunology 4, no. 3 (January 1990): 159–74. http://dx.doi.org/10.1089/pai.1990.4.159.

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18

Süsal, C., and G. Opelz. "Options for Immunologic Support of Renal Transplantation Through the HLA and Immunology Laboratories." American Journal of Transplantation 7, no. 6 (June 2007): 1450–56. http://dx.doi.org/10.1111/j.1600-6143.2007.01824.x.

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19

DeMoss, Patrick, Mohamed Asfour, and Kelly Hersey. "Anti-K1 (Kell) Antibody Expressed in Maternal Breastmilk: A Case Report of a Neonate with Multiple Intrauterine Transfusions and Postnatal Exposure to Kell Antibody in Maternal Breastmilk." Case Reports in Pediatrics 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/6927813.

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Hemolytic disease of the fetus and newborn is a common consideration in newborn medicine, especially among the jaundiced. Maternal breastmilk provides numerous benefits to the infant, including nutrition and immunologic factors. Here, we present an infant who received three intrauterine transfusions for anemia secondary to anti-K1 (Kell), anti-C, and anti-e antibodies and whose maternal breastmilk tested positive for anti-Kell antibodies. The infant required another transfusion at 4 weeks of life for anemia. We review the pathophysiology of anti-Kell antibodies, the immunology of breast milk, and the intersection of these two topics.

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20

Jain, Akhil, and Sajjan Rajpurohit. "Cancer immunotherapy." International Journal of Molecular and Immuno Oncology 3, no. 2 (July 25, 2018): 45. http://dx.doi.org/10.18203/issn.2456-3994.intjmolimmunooncol20183227.

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<p class="s4">The era has begun where oncology meets immunology. The recent advancement in the field of molecular biology has led to the discovery of various pathways through which cancer establishes, proliferates, grows, and disseminates. These pathways provided major insight for targeting specific molecules with the targeted therapies that show predicted responses. This targeted therapy is usually referred to as immunotherapy. These immunotherapies possess and display a unique set of toxicities mainly immunologic in nature and different from chemotherapies. This article focuses on mechanisms of immune activity of the body and various therapies available to boost these mechanisms.</p>

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21

Matsui, Yuichi, Akio Saiura, Yasuhiko Sugawara, Masataka Sata, Katsutoshi Naruse, Hideo Yagita, Takahide Kohro, et al. "Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade." Physiological Genomics 15, no. 3 (November 11, 2003): 199–208. http://dx.doi.org/10.1152/physiolgenomics.00086.2003.

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The induction of specific tolerance would be the ultimate achievement in transplant immunology, but the precise mechanisms of immunologic tolerance remain largely unknown. Here, we investigated global gene expression analysis in tolerizing murine cardiac allografts by means of oligonucleotide microarrays. Tolerance induction was achieved in cardiac allografts from BALB/c to C57BL/6 mice by daily intraperitoneal injection of anti-CD80 and anti-CD86 monoclonal antibodies (mAbs). Comparative analysis revealed 64 genes to be induced more extensively in the tolerizing than in the syngeneic isografts, and 16 genes than in the rejecting allografts. Two genes were specifically upregulated in the tolerizing allografts. In the tolerizing allografts there were induced marked expressions of a number of genes for pro-inflammatory factors, including interferon-γ-inducible cytokines and chemokines, as well as apoptosis-related genes, which were also upregulated in the rejecting allografts. Moreover, these gene expression patterns continued to be upregulated more than 70 days posttransplant. These results provide evidence that immunologic tolerance can be induced and maintained in the presence of prominent pro-inflammatory gene expression in vivo.

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22

Tsuruta, Daisuke, Amrinder J. Kanwar, Keshavamurthy Vinay, Shunpei Fukuda, Hiroshi Koga, Teruki Dainichi, Chika Ohata, Norito Ishii, and Takashi Hashimoto. "Clinical and Immunologic Characterization in 26 Indian Pemphigus Patients." Journal of Cutaneous Medicine and Surgery 17, no. 5 (September 2013): 321–31. http://dx.doi.org/10.2310/7750.2013.12097.

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Background: Pemphigus shows geographically variable characteristics. Objective: To study the clinical and immunologic characteristics of Indian pemphigus patients before and after treatment. Methods: Twenty-six Indian pemphigus patients were analyzed with regard to age, gender, clinical features, treatments and response, the results of histopathology, direct and indirect immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), and immunoblot analyses. Results: There were 22 pemphigus vulgaris (PV) and 4 pemphigus foliaceus (PF) patients. Direct and indirect IF was positive in 95.8% and 56% of patients, respectively. Indices of ELISA were lower in our study. Immunoblot assays detected the 130 kDa desmoglein-3 in 10 PV patients and the 160 kDa desmoglein-1 in 1 PV patient; 190 kDa periplakin was unexpectedly detected in 8 patients. Conclusion: Indian pemphigus patients showed several unique characteristics, including younger population, predominance of PV, low ELISA indices, lower sensitivity of indirect IF and immunoblotting, and the presence of the 190 kDa periplakin in nearly one-third of patients.

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23

Baltch, Aldona L., Tom G. Obrig, Raymond P. Smith, Mark C. Hammer, Joseph V. Conroy, and Frieder Lutz. "Production of cytotoxin by clinical strains of Pseudomonas aeruginosa." Canadian Journal of Microbiology 33, no. 2 (February 1, 1987): 104–11. http://dx.doi.org/10.1139/m87-018.

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Presence of cytotoxin was studied in extracts of 57 strains of Pseudomonas aeruginosa (46 bacteremia, 4 environmental, and 7 Fisher immunotype), 10 Pseudomonas species, and 7 nonpseudomonas isolates. Cytotoxin was identified by Western immunoblot in extracts of all P. aeruginosa isolates. None of the Pseudomonas species or nonpseudomonas isolates were shown to produce this protein. No immunologic cross-reactivity was observed between cytotoxin antibody and P. aeruginosa alkaline protease, toxin A, or elastase. In partially purified extracts of two bacteremia strains and PA 158 (parent strain for cytotoxin production), detection of cytotoxin by Western immunoblot was correlated with biological activity, as measured by the cell swelling assay. Cytotoxin appears to be produced by all strains of P. aeruginosa and biological activity can be demonstrated in extracts of the strains tested. This biological activity is neutralized by specific antibody. Because of its known marked cytotoxic effect on most eukaryotic cells, P. aeruginosa cytotoxin might be an important factor in the pathogenesis of P. aeruginosa infections.

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Zimmerman, Thomas E., Barbara J. Deeb, and Ronald F. DiGiacomo. "Polypeptides associated with Pasteurella multocida infection in rabbits." American Journal of Veterinary Research 53, no. 7 (July 1, 1992): 1108–12. http://dx.doi.org/10.2460/ajvr.1992.53.7.1108.

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Summary Polypeptides from whole cell preparations of Pasteurella multocida serotypes A: 12 and A:3 were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and transferred to nitrocellulose paper. Antigens were detected by immunoblot analysis, using sera from 3 groups of rabbits. Sera were obtained from rabbits inoculated intranasally with P multocida serotype A: 12 or A:3, from rabbits maintained in a rabbitry with enzootic P multocida A: 12 infection, and from rabbits maintained in a rabbitry with enzootic P multocida A:3 infection. Immunoblot analyses of pre- and postinoculation sera from experimentally infected rabbits, using serotype A: 12 antigen, revealed 3 polypeptides with approximate molecular mass of 28, 30, and 37 kDa that consistently detected antibodies after P multocida-induced infection. Sera from rabbits naturally infected with either serotype, tested against serotype A: 12 and A:3 antigens, detected the same polypeptides in both serotypes. Thus, immunologic reactivity to these polypeptides may be useful for serologic detection of P multocida infection.

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Kabanikhin, S. I., O. I. Krivorotko, D. V. Ermolenko, V. N. Kashtanova, and V. A. Latyshenko. "INVERSE PROBLEMS OF IMMUNOLOGY AND EPIDEMIOLOGY." Eurasian Journal of Mathematical and Computer Applications 5, no. 2 (2017): 14–35. http://dx.doi.org/10.32523/2306-3172-2017-5-2-14-35.

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26

Nihal Arzu, MIRICI. "Pulmonology And Immunology; A Brief Overview." Archives of Immunology Research and Therapy 1, no. 1 (December 27, 2022): 01–03. http://dx.doi.org/10.58489/2836-5003/002.

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Pulmonary diseases are very common worldwide and have high mortality and morbidity rates. When we look at the pathogenetic processes of these diseases, it is seen that the natural and adaptive immune response plays an important role. As in many diseases, immune modulatory therapy is the current treatment approach in pulmonary diseases. In our article, we aimed to take a quick look at the immune system in common pulmonary diseases.

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27

Author, A. "Proceedings of the Symposium “Klinische Immunologie” (Clinical Immunology) 4 March 1999, Academic Medical Center, Amsterdam." Netherlands Journal of Medicine 55, no. 3 (September 1999): A1—A9. http://dx.doi.org/10.1016/s0300-2977(99)00062-5.

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28

King, Christine A., and Mark R. Wills. "Immunology I: innate immunology." Surgery (Oxford) 23, no. 8 (August 2005): 304–8. http://dx.doi.org/10.1383/surg.2005.23.8.304.

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29

Hastings, R. C., T. P. Gillis, J. L. Krahenbuhl, and S. G. Franzblau. "Leprosy." Clinical Microbiology Reviews 1, no. 3 (July 1988): 330–48. http://dx.doi.org/10.1128/cmr.1.3.330.

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Leprosy affects over 10 million people in the world. The disease is a model of graded cell-mediated immunity, in this case to the causative organism, Mycobacterium leprae. The clinical manifestations are due to (i) bacterial progression, (ii) immunologic responses of the host, (iii) peripheral nerve damage due to either or both bacterial progression and immunologic responses of the host, and (iv) preventable secondary deformities following nerve damage, which account for most of the stigma of the disease. Treatment modalities are now available to control or minimize the effects of bacterial progression, harmful immunologic responses of the host, peripheral nerve damage, and secondary deformities. Unique biochemical characteristics of M. leprae reside in the cell wall and associated macromolecules. Some of these molecules are potent immunogens in humans, while others constitute the structural integrity of the bacillus. Proteins of M. leprae are currently under intensive investigation as a result of deoxyribonucleic acid cloning of M. leprae genes. Structure-function and antigenic relationships of M. leprae proteins should become available by using recombinant deoxyribonucleic acid procedures coupled with T- and B-cell cloning to advance our understanding of the immunologic reactions encountered in Hansen's disease. Until recently, the study of the immunology of leprosy has been stymied by the lack of immunologically specific M. leprae antigens. The definition of specific antigens and production of recombinant and synthetic immunologic reagents have fostered state-of-the-art research efforts into new immunodiagnostic procedures and development of a leprosy vaccine. Also discussed is progress in understanding of the mechanism(s) underlying the M. leprae-specific immunodeficiency associated with lepromatous leprosy, including the role of suppressor T cells and defective macrophage function. Metabolic studies of M. leprae suggest intact catabolic pathways and energy generation with purine bases and catalase as possible growth factors. Special attention may also need to be given to biophysical parameters for eventual in vitro cultivation. Rapid in vitro systems, using quantitation of bacillary metabolic activity, may soon replace the lengthy mouse footpad test for determining the viability and drug susceptibility of the leprosy bacillus.

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Bogomolov, Artemii. "DEFINITION OF SENSITIZATION TO POLLEN ALLERGENS WORMWOOD AND HAZEL IN PATIENTS WITH RESPIRATORY ALLERGIC DISEASES BY IMMUNOBLOT AND MULTIPLEX COMPONENT TEST." Immunology and Allergy: Science and Practice, no. 1 (April 8, 2020): 39–44. http://dx.doi.org/10.37321/immunology.2020.01-06.

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The aim of our study was to evaluate the diagnostic parameters of immunoblot and Immunocap ISAC methods to determine allergic sensitization to wormwood and hazel in patients with respiratory allergic diseases – allergic rhinitis and bronchial asthma. Materials and methods. In this study, 40 patients with bronchial asthma and / or allergic rhinitis were examined with two different methods of specific allergic diagnosis (in vitro). The study was open-ended, comparative. Quantitative determination of specific IgE in the serum was performed using the RIDA® AllergyScreen immunoblot method (R-Biopharm AG, Germany) on the basis of the private laboratory of LLC “Allergy-Immunological Center KPP”. Immunocap ISAC testing was performed at “Forpost Allergy and Immunology Clinic”. Results and Discussion. Among patients, allergic sensitization to wormwood was 27.5% (11 people) in the presence of specific IgE by the Rida AllergyScreen method, 25.0% (10 people) in the presence of specific IgE using ImmunoCAP ISAC; sensitization to hazel allergen was 27.5% (11 people) in the presence of specific IgE on Rida AllergyScreen, 30.0% (12 people) in the presence of specific IgE from ImmunoCAP ISAC. For the determination of specific IgE to wormwood allergen the immunoblot has a high sensitivity and negative predictive value (100.00% in both cases) compared to ISAC, a high specificity of 96.67% (95% CI: 82.78; 99.92), but a positive predicitive value was 90.91% (95% CI: 59.28; 98.57) and accuracy was 97.50% (95% CI: 86.84; 99.94). Conclusions. Immunoblot compared to ISAC for the determination of specific IgE to hazel allergen has a relatively high specificity and negative predictive value (92.86% and 89,66%), but the sensitivity and positive predicitive value were 75.00% (95 % CI: 42.81; 94.51) and 81.82% (95% CI: 53.23; 94.68), respectively, and the accuracy of the method was 87.50% (95% CI: 73.20; 95.81).

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Kronbichler, Andreas, Johannes Leierer, Jun Oh, Björn Meijers, and Jae Il Shin. "Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis." BioMed Research International 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/2150451.

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Focal segmental glomerulosclerosis is a histological pattern on renal biopsy caused by diverse mechanisms. In its primary form, a circulatory factor is implicated in disease onset and recurrence. The natural history of primary FSGS is unpredictable, since some patients are unresponsive towards immunosuppressive measures. Immunologic changes, leading to a proinflammatory or profibrotic milieu, have been implicated in disease progression, namely, glomerular scarring, eventually leading to end-stage renal disease. Among these, interleukin-1ß, tumor-necrosis factor-α(TNF-α), and transforming growth factor-ß1 (TGF-ß1) have emerged as important factors. Translating these findings into clinical practice dampened the enthusiasm, since both TNF-αand TGF-ß1 blockade failed to achieve significant control of the disease. More recently, a role of the complement system has been demonstrated which in fact may be another attractive target in clinical practice. Rituximab, blocking CD20-bearing cells, demonstrated conflicting data regarding efficacy in FSGS. Finally, the T-cell costimulating molecule B7-1 (CD80) is implicated in development of proteinuria in general. Blockade of this target demonstrated significant benefits in a small cohort of resistant patients. Taken together, this review focuses on immunology of FSGS, attributable to either the disease or progression, and discusses novel therapeutic approaches aiming at targeting immunologic factors.

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Rossi, Lara, Valentina Salvestrini, Davide Ferrari, Francesco Di Virgilio, and Roberto M. Lemoli. "The sixth sense: hematopoietic stem cells detect danger through purinergic signaling." Blood 120, no. 12 (September 20, 2012): 2365–75. http://dx.doi.org/10.1182/blood-2012-04-422378.

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Abstract Over the past decade, extracellular nucleotides (such as ATP and UTP) have emerged as key immunomodulators. This family of molecules, already known for its key metabolic functions, has been the focus of intense investigation that has unambiguously shown its crucial role as mediators of cell-to-cell communication. More recently, in addition to its involvement in inflammation and immunity, purinergic signaling has also been shown to modulate BM-derived stem cells. Extracellular nucleotides promote proliferation, CXCL12-driven migration, and BM engraftment of hematopoietic progenitor and stem cells. In addition, purinergic signaling acts indirectly on hematopoietic progenitor and stem cells by regulating differentiation and release of proinflammatory cytokines in BM-derived human mesenchymal stromal cells, which are part of the hematopoietic stem cell (HSC) niche. HSC research has recently blended into the field of immunology, as new findings highlighted the role played by immunologic signals (such as IFN-α, IFN-γ, or TNF-α) in the regulation of the HSC compartment. In this review, we summarize recent reports unveiling a previously unsuspected ability of HSCs to integrate inflammatory signals released by immune and stromal cells, with particular emphasis on the dual role of extracellular nucleotides as mediators of both immunologic responses and BM stem cell functions.

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Bonagura, Vincent R., and Jean Laurent Casanova. "The Journal of Clinical Immunology: An international Journal for Primary Immunodeficiencies and Related Human Immunologic Diseases." Journal of Clinical Immunology 33, no. 8 (November 2013): 1271–72. http://dx.doi.org/10.1007/s10875-013-9958-2.

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Shah, Javeed A., Cecilia S. Lindestam Arlehamn, David J. Horne, Alessandro Sette, and Thomas R. Hawn. "Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis." Journal of Infectious Diseases 220, no. 7 (June 4, 2019): 1091–98. http://dx.doi.org/10.1093/infdis/jiz285.

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AbstractDevelopment of an improved tuberculosis (TB) vaccine is a high worldwide public health priority. Bacillus Calmette-Guerin (BCG), the only licensed TB vaccine, provides variable efficacy against adult pulmonary TB, but why this protection varies is unclear. Humans are regularly exposed to non-tuberculous mycobacteria (NTM) that live in soil and water reservoirs and vary in different geographic regions around the world. Immunologic cross-reactivity may explain disparate outcomes of BCG vaccination and susceptibility to TB disease. Evidence supporting this hypothesis is increasing but challenging to obtain due to a lack of reliable research tools. In this review, we describe the progress and bottlenecks in research on NTM epidemiology, immunology and heterologous immunity to Mtb. With ongoing efforts to develop new vaccines for TB, understanding the effect of NTM on vaccine efficacy may be a critical determinant of success.

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Wu, Chih-Te, Paul A. Davis, VelImir A. Luketic, and M. Eric Gershwin. "A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias." Clinical and Developmental Immunology 11, no. 3-4 (2004): 205–13. http://dx.doi.org/10.1080/17402520400004177.

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Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.

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Azegami, Tatsuhiko, and Hiroshi Itoh. "Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension." International Journal of Hypertension 2019 (August 14, 2019): 1–8. http://dx.doi.org/10.1155/2019/9218531.

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Hypertension is a global public health issue and the most important preventable cause of cardiovascular diseases. Despite the clinical availability of many antihypertensive drugs, many hypertensive patients have poor medication adherence and blood pressure control due, at least partially, to the asymptomatic and chronic characteristics of hypertension. Immunotherapeutic approaches have the potential to improve medication adherence in hypertension because they induce prolonged therapeutic effects and need a low frequency of administration. The first attempts to reduce blood pressure by using vaccines targeting the renin-angiotensin system were made more than half a century ago; however, at the time, a poor understanding of immunology and the mechanisms of hypertension and a lack of optimal vaccine technologies such as suitable antigen design, proper adjuvants, and effective antigen delivery systems meant that attempts to develop antihypertensive vaccines failed. Recent advances in immunology and vaccinology have provided potential therapeutic immunologic approaches to treat not only infectious diseases but also cancers and other noncommunicable diseases. One important biotechnology that has had a major impact on modern vaccinology is virus-like particle technology, which can efficiently deliver vaccine antigens without the need for artificial adjuvants. A human clinical trial that indicated the effectiveness and safety of a virus-like particle-based antiangiotensin II vaccine marked a turning point in the field of therapeutic antihypertensive vaccines. Here, we review the history of the development of immunotherapies for the treatment of hypertension and discuss the current perspectives in the field.

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Lord, Richard. "Immunology." American Biology Teacher 82, no. 3 (March 1, 2020): 181–83. http://dx.doi.org/10.1525/abt.2020.82.3.181b.

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38

Walker, W. Allan. "Immunology." Current Opinion in Gastroenterology 7, no. 3 (June 1991): 418–20. http://dx.doi.org/10.1097/00001574-199106000-00013.

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&NA;. "Immunology." Current Opinion in Gastroenterology 7, no. 3 (June 1991): 520–30. http://dx.doi.org/10.1097/00001574-199106000-00021.

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Walker, W. Allan. "Immunology." Current Opinion in Gastroenterology 8, no. 6 (December 1992): 963–66. http://dx.doi.org/10.1097/00001574-199212000-00012.

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&NA;. "Immunology." Current Opinion in Gastroenterology 8, no. 6 (December 1992): 1044–68. http://dx.doi.org/10.1097/00001574-199212000-00021.

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&NA;. "Immunology." Current Opinion in Gastroenterology 9, no. 6 (November 1993): 1034–58. http://dx.doi.org/10.1097/00001574-199309060-00018.

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Walker, W. Allan. "Immunology." Current Opinion in Gastroenterology 10, no. 6 (November 1994): 623–24. http://dx.doi.org/10.1097/00001574-199411000-00009.

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&NA;, &NA;. "Immunology." Current Opinion in Gastroenterology 10, no. 6 (November 1994): B187—B206. http://dx.doi.org/10.1097/00001574-199411000-00019.

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Walker, W. Allan. "Immunology." Current Opinion in Gastroenterology 11, no. 6 (November 1995): 509–11. http://dx.doi.org/10.1097/00001574-199511000-00008.

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&NA;. "Immunology." Current Opinion in Gastroenterology 11, no. 6 (November 1995): i. http://dx.doi.org/10.1097/00001574-199511000-00017.

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&NA;, &NA;. "Immunology." Current Opinion in Gastroenterology 12, no. 6 (November 1996): B116—B128. http://dx.doi.org/10.1097/00001574-199611000-00019.

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Fusunyan, Robert D., and W. Allan Walker. "Immunology." Current Opinion in Gastroenterology 13, no. 6 (November 1997): 491–93. http://dx.doi.org/10.1097/00001574-199711000-00009.

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&NA;, &NA;. "Immunology." Current Opinion in Gastroenterology 13, no. 6 (November 1997): B172—B202. http://dx.doi.org/10.1097/00001574-199711000-00018.

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Walker, W. Allan. "Immunology." Current Opinion in Gastroenterology 16, no. 6 (November 2000): 527–30. http://dx.doi.org/10.1097/00001574-200011000-00011.

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