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Journal articles on the topic 'Immuno-Epidemiological'

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Published: 1 February 2023

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1

Bhattacharya, Souvik, and Maia Martcheva. "An immuno-eco-epidemiological model of competition." Journal of Biological Dynamics 10, no. 1 (2016): 314–41. http://dx.doi.org/10.1080/17513758.2016.1186291.

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2

Banerjee, Malay, Alexey Tokarev, and Vitaly Volpert. "Immuno-epidemiological model of two-stage epidemic growth." Mathematical Modelling of Natural Phenomena 15 (2020): 27. http://dx.doi.org/10.1051/mmnp/2020012.

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Epidemiological data on seasonal influenza show that the growth rate of the number of infected individuals can increase passing from one exponential growth rate to another one with a larger exponent. Such behavior is not described by conventional epidemiological models. In this work an immuno-epidemiological model is proposed in order to describe this two-stage growth. It takes into account that the growth in the number of infected individuals increases the initial viral load and provides a passage from the first stage of epidemic where only people with weak immune response are infected to the
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3

Gupta, Churni, Necibe Tuncer, and Maia Martcheva. "A network immuno-epidemiological model of HIV and opioid epidemics." Mathematical Biosciences and Engineering 20, no. 2 (2022): 4040–68. http://dx.doi.org/10.3934/mbe.2023189.

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<abstract><p>In this paper, we introduce a novel multi-scale network model of two epidemics: HIV infection and opioid addiction. The HIV infection dynamics is modeled on a complex network. We determine the basic reproduction number of HIV infection, $ \mathcal{R}_{v} $, and the basic reproduction number of opioid addiction, $ \mathcal{R}_{u} $. We show that the model has a unique disease-free equilibrium which is locally asymptotically stable when both $ \mathcal{R}_{u} $ and $ \mathcal{R}_{v} $ are less than one. If $ \mathcal{R}_{u} > 1 $ or $ \mathcal{R}_{v} > 1 $,
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Gupta, Churni, Necibe Tuncer, and Maia Martcheva. "Immuno-epidemiological co-affection model of HIV infection and opioid addiction." Mathematical Biosciences and Engineering 19, no. 4 (2022): 3636–72. http://dx.doi.org/10.3934/mbe.2022168.

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<abstract><p>In this paper, we present a multi-scale co-affection model of HIV infection and opioid addiction. The population scale epidemiological model is linked to the within-host model which describes the HIV and opioid dynamics in a co-affected individual. CD4 cells and viral load data obtained from morphine addicted SIV-infected monkeys are used to validate the within-host model. AIDS diagnoses, HIV death and opioid mortality data are used to fit the between-host model. When the rates of viral clearance and morphine uptake are fixed, the within-host model is structurally iden
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5

GULBUDAK, HAYRIYE. "AN IMMUNO-EPIDEMIOLOGICAL VECTOR–HOST MODEL WITH WITHIN-VECTOR VIRAL KINETICS." Journal of Biological Systems 28, no. 02 (2020): 233–75. http://dx.doi.org/10.1142/s0218339020400021.

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A current challenge for disease modeling and public health is understanding pathogen dynamics across scales since their ecology and evolution ultimately operate on several coupled scales. This is particularly true for vector-borne diseases, where within-vector, within-host, and between vector–host populations all play crucial roles in diversity and distribution of the pathogen. Despite recent modeling efforts to determine the effect of within-host virus-immune response dynamics on between-host transmission, the role of within-vector viral dynamics on disease spread is overlooked. Here, we form
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Barfield, Michael, Maia Martcheva, Necibe Tuncer, and Robert D. Holt. "Backward bifurcation and oscillations in a nested immuno-eco-epidemiological model." Journal of Biological Dynamics 12, no. 1 (2017): 51–88. http://dx.doi.org/10.1080/17513758.2017.1401676.

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7

Welker, Jonathan Shane, and Maia Martcheva. "A novel multi-scale immuno-epidemiological model of visceral leishmaniasis in dogs." BIOMATH 8, no. 1 (2019): 1901026. http://dx.doi.org/10.11145/j.biomath.2019.01.026.

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Leishmaniasis is a neglected and emerging disease prevalent in Mediterranean and tropical climates. As such, the study and development of new models are of increasing importance. We introduce a new immuno-epidemiological model of visceral leishmaniasis in dogs. The within-host system is based on previously collected and published data, showing the movement and proliferation of the parasite in the skin and the bone-marrow, as well as the IgG response. The between-host system structures the infected individuals in time-since-infection and is of vector-host type. The within-host system has a para
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8

Abo-Sheishaa, Gamal A., Morsy R. M. Geneedy, and Anwar H. Abu-Hashim. "House Dust Mites in Eastern Part of the Delta Immuno - Epidemiological Study." Al-Azhar Medical Journal 42, no. 4 (2013): 725–34. http://dx.doi.org/10.12816/0015736.

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9

Gulbudak, Hayriye, Vincent L. Cannataro, Necibe Tuncer, and Maia Martcheva. "Vector-Borne Pathogen and Host Evolution in a Structured Immuno-Epidemiological System." Bulletin of Mathematical Biology 79, no. 2 (2016): 325–55. http://dx.doi.org/10.1007/s11538-016-0239-0.

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10

Dang, Yan-Xia, Xue-Zhi Li, and Maia Martcheva. "Competitive exclusion in a multi-strain immuno-epidemiological influenza model with environmental transmission." Journal of Biological Dynamics 10, no. 1 (2016): 416–56. http://dx.doi.org/10.1080/17513758.2016.1217355.

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11

Struik, Siske S., Fakhreldin M. Omer, Katerina Artavanis-Tsakonas, and Eleanor M. Riley. "Uninfected erythrocytes inhibit Plasmodium falciparum–induced cellular immune responses in whole-blood assays." Blood 103, no. 8 (2004): 3084–92. http://dx.doi.org/10.1182/blood-2003-08-2867.

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Abstract Whole-blood assays (WBAs) have been successfully used as a simple tool for immuno-epidemiological field studies evaluating cellular immune responses to mycobacterial and viral antigens. Rather unexpectedly, we found very poor cytokine responses to malaria antigens in WBAs in 2 immuno-epidemiological studies carried out in malaria endemic populations in Africa. We have therefore conducted a detailed comparison of cellular immune responses to live (intact) and lysed malaria-infected erythrocytes in WBAs and in peripheral blood mononuclear cell (PBMC) cultures. We observed profound inhib
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12

Mendis, Chandana, Asoka C. Gamage-Mendis, Kamini N. Mendis, et al. "Characteristics of Malaria Transmission in Kataragama, Sri Lanka: A Focus for Immuno-Epidemiological Studies." American Journal of Tropical Medicine and Hygiene 42, no. 4 (1990): 298–308. http://dx.doi.org/10.4269/ajtmh.1990.42.298.

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13

Sagna, André, Mabo Yobo, Emmanuel Elanga Ndille, and Franck Remoue. "New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications." Tropical Medicine and Infectious Disease 3, no. 3 (2018): 80. http://dx.doi.org/10.3390/tropicalmed3030080.

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Arthropod-borne viruses (arboviruses) such as dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), and yellow fever virus (YFV) are the most important ‘emerging pathogens’ because of their geographic spread and their increasing impact on vulnerable human populations. To fight against these arboviruses, vector control strategies (VCS) remain one of the most valuable means. However, their implementation and monitoring are labour intensive and difficult to sustain on large scales, especially when transmission and Aedes mosquito densities are low. To increase the efficacy of VCS, cur
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14

Mobisa, B., G. O. Lawi, and J. K. Nthiiri. "An immuno-epidemiological model for HIV/AIDS incorporating viral and cellular transmission with antiretroviral treatment." Applied Mathematical Sciences 13, no. 23 (2019): 1129–45. http://dx.doi.org/10.12988/ams.2019.910142.

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15

Traoré, Dipomin F., André B. Sagna, Akré M. Adja, et al. "Evaluation of Malaria Urban Risk Using an Immuno-Epidemiological Biomarker of Human Exposure to Anopheles Bites." American Journal of Tropical Medicine and Hygiene 98, no. 5 (2018): 1353–59. http://dx.doi.org/10.4269/ajtmh.17-0231.

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16

Gulbudak, Hayriye, and Cameron J. Browne. "Infection severity across scales in multi-strain immuno-epidemiological Dengue model structured by host antibody level." Journal of Mathematical Biology 80, no. 6 (2020): 1803–43. http://dx.doi.org/10.1007/s00285-020-01480-3.

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17

Arama, Charles, Bakary Maiga, Amagana Dolo, et al. "Ethnic differences in susceptibility to malaria: What have we learned from immuno-epidemiological studies in West Africa?" Acta Tropica 146 (June 2015): 152–56. http://dx.doi.org/10.1016/j.actatropica.2015.03.023.

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18

Cai, Liming, Necibe Tuncer, and Maia Martcheva. "How does within-host dynamics affect population-level dynamics? Insights from an immuno-epidemiological model of malaria." Mathematical Methods in the Applied Sciences 40, no. 18 (2017): 6424–50. http://dx.doi.org/10.1002/mma.4466.

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19

Tuncer, Necibe, Hayriye Gulbudak, Vincent L. Cannataro, and Maia Martcheva. "Structural and Practical Identifiability Issues of Immuno-Epidemiological Vector–Host Models with Application to Rift Valley Fever." Bulletin of Mathematical Biology 78, no. 9 (2016): 1796–827. http://dx.doi.org/10.1007/s11538-016-0200-2.

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20

Qesmi, Redouane, Jane M. Heffernan, and Jianhong Wu. "An immuno-epidemiological model with threshold delay: a study of the effects of multiple exposures to a pathogen." Journal of Mathematical Biology 70, no. 1-2 (2014): 343–66. http://dx.doi.org/10.1007/s00285-014-0764-0.

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21

Urdaneta, Haydeé, Antonio Rangel, Maria Sonia Martins, Jose Francisco Muñoz, and Manuel Hernández M. "Entamoeba histolytica: fecal antigen capture immunoassay for the diagnosis of enteric amebiasis by a monoclonal antibody." Revista do Instituto de Medicina Tropical de São Paulo 38, no. 1 (1996): 39–44. http://dx.doi.org/10.1590/s0036-46651996000100008.

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Amebiasis continues to be of epidemiological importance in underdeveloped countries. Clinical diagnosis and epidemiological setting in a region are based on the fecal microscopic identification of cysts or trophozoites. This procedure requires well trained personnel, is laborious, of low sensitivity and frequently yields false-positives results. The present study was designed to develop an immuno-enzymatic fecal 96 kDa antigen capture test (COPROELISA-Eh) more sensitive and specific than microscopic diagnosis of amebiasis. Triplicates of 177 stool samples processed by the formol-ether concentr
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22

Otranto, D., G. Testini, R. Sottili, G. Capelli, and V. Puccini. "Screening of commercial milk samples using ELISA for immuno-epidemiological evidence of infection by the cattle grub (Diptera: Oestridae)." Veterinary Parasitology 99, no. 3 (2001): 241–48. http://dx.doi.org/10.1016/s0304-4017(01)00463-0.

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23

V., Srividya, and Kruthika N. "Clinico-epidemiological profile of dengue cases in a Medical College Hospital, Bengaluru, Karnataka, India." International Journal Of Community Medicine And Public Health 4, no. 4 (2017): 928. http://dx.doi.org/10.18203/2394-6040.ijcmph20170928.

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Background: Medical college hospital being a tertiary care center receives a significant number of dengue cases from within and outside the catchment area and provides a good opportunity to study the clinical and epidemiological features of dengue infection, its prognosis and outcome so as to institute prompt preventive and control measures. The objective was to describe the clinico-epidemiological features of dengue cases admitted to pediatric ward at a Medical College Hospital, Bengaluru, Karnataka, India.Methods: Cross-sectional study of 140 cases positive for NS1Ag, IgM and/or IgG by dengu
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24

Bundy, D. A. P., and G. F. Medley. "Immuno-epidemiology of human geohelminthiasis: ecological and immunological determinants of worm burden." Parasitology 104, S1 (1992): S105—S119. http://dx.doi.org/10.1017/s0031182000075284.

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SUMMARYThe morbidity and transmission dynamics of geohelminthiases are determined by the patterns of infection intensity in the community. Understanding the determinants of these patterns requires a combination of field, laboratory and theoretical study. Studies of age-specific reinfection, and of the phenomenon of predisposition, indicate that the major determinant of convex age-intensity profiles and of heterogeneity in infection intensity is the rate of establishment of infection, rather than the rate of adult worm mortality. The rate of establishment is, in turn, determined by exposure to,
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Hafiz, Taghreed A., Alaa Albloshi, Ohoud S. Alhumaidan, et al. "The Epidemiological Pattern, Resistance Characteristics and Clinical Outcome of Enterobacter cloacae: Recent Updates and Impact of COVID-19 Pandemic." Healthcare 11, no. 3 (2023): 312. http://dx.doi.org/10.3390/healthcare11030312.

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Objectives: E. cloacae is an opportunistic organism that causes serious infections, particularly in immuno-compromised and hospitalized patients, along with the emergence of resistance traits. The COVID-19 pandemic has impacted the epidemiological pattern and resistance traits of E. cloacae infections as well as those of other bacteria. The study aims to assess the epidemiological patterns, resistance characteristics and clinical outcomes of E. cloacae in Saudi Arabia and the impact of the COVID-19 pandemic. Methods: King Fahad Medical City in Riyadh provided the data between January 2019 and
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26

CIMINO, R. O., M. MONJE RUMI, P. RAGONE, et al. "Immuno-enzymatic evaluation of the recombinant TSSA-II protein ofTrypanosoma cruziin dogs and human sera: a tool for epidemiological studies." Parasitology 138, no. 8 (2011): 995–1002. http://dx.doi.org/10.1017/s0031182011000540.

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SUMMARYThe rTSSA-II (recombinant Trypomastigote Small Surface II) antigen was evaluated by ELISA to detect anti-Trypanosoma cruziantibodies in sera from naturally infected dogs and humans. For this evaluation ELISA-rTSSA-II was standardized and groups were classified according to the results obtained through xenodiagnosis, ELISA and PCR. Sensitivity (Se), Specificity (Sp), Kappa index (KI) and area under curve (AUC) were determined. The Se was determined by using 14 sera from dogs infected withT. cruziVI (TcVI) whereas Sp was determined by using 95 non-chagasic sera by xenodiagnosis, ELISA-Hom
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27

Ghosh, Samiran, Vitaly Volpert, and Malay Banerjee. "An Epidemic Model with Time Delay Determined by the Disease Duration." Mathematics 10, no. 15 (2022): 2561. http://dx.doi.org/10.3390/math10152561.

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Immuno-epidemiological models with distributed recovery and death rates can describe the epidemic progression more precisely than conventional compartmental models. However, the required immunological data to estimate the distributed recovery and death rates are not easily available. An epidemic model with time delay is derived from the previously developed model with distributed recovery and death rates, which does not require precise immunological data. The resulting generic model describes epidemic progression using two parameters, disease transmission rate and disease duration. The disease
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28

Pritchard, D. I., R. J. Quinnell, A. F. G. Slater, et al. "Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens." Parasitology 100, no. 2 (1990): 317–26. http://dx.doi.org/10.1017/s0031182000061333.

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SUMMARYBaseline data from an immuno-epidemiological study of hookworm infection in a rural village in Madang Province, Papua New Guinea are reported. Necator americanus was found to be the commonest helminth infection, with a prevalence of near 100% and intensity of 40 worms per host in adults. Enterobius vermicularis, Ascaris lumbricoides and Trichuris trichiura were also present, at prevalences of 53, 10 and 3% respectively; Ancylostoma duodenale was absent. The frequency distribution of N. americanus was highly over-dispersed, and was well described by a negative binomial distribution with
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29

Skowronski, Danuta M., Catharine Chambers, Suzana Sabaiduc, et al. "Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the 2015–2016 Season in Canada." Journal of Infectious Diseases 216, no. 12 (2017): 1487–500. http://dx.doi.org/10.1093/infdis/jix526.

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30

Welker, Jonathan Shane, and Maia Martcheva. "Analysis and simulations with a multi-scale model of canine visceral leishmaniasis." Mathematical Modelling of Natural Phenomena 15 (2020): 72. http://dx.doi.org/10.1051/mmnp/2020026.

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Visceral leishmaniasis in dogs is believed to have an impact on the prevalence of the disease in human populations. Here, we continue the analysis of the nested immuno-epidemiological model of visceral leishmaniasis in dogs, including a proof of well-posedness using functional analytical methods. Once well-posedness is established, we continue stability analysis of the endemic equilibria and provide necessary and sufficient conditions for the presence of backward bifurcation, and prove the instability of the lower endemic equilibrium in the presence of backward bifurcation. Lastly, we provide
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31

Baghel, Nekram, Sankalp Awasthi, and Sweta S. Kumar. "Epidemiological study of herpes zoster in a tertiary care hospital." International Journal of Research in Medical Sciences 5, no. 10 (2017): 4550. http://dx.doi.org/10.18203/2320-6012.ijrms20174594.

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Background: Herpes Zoster, which presents as a localized, painful cutaneous eruption is a common clinical problem, caused by reactivation of latent Varicella Zoster Virus (VZV) and is usually self- limiting in healthy adults. In this era of HIV infection, HIV seropositive patients are at increased risk of severe or disseminated cutaneous or visceral involvement. Aim was to analyse the clinical pattern and epidemiological factors of Herpes Zoster and to know the HIV prevalence among patients with Herpes Zoster.Methods: A total of 110 patients with Herpes Zoster attending dermatology department
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Poinsignon, Anne, Badara Samb, Souleymane Doucoure, et al. "First attempt to validate the gSG6-P1 salivary peptide as an immuno-epidemiological tool for evaluating human exposure to Anopheles funestus bites." Tropical Medicine & International Health 15, no. 10 (2010): 1198–203. http://dx.doi.org/10.1111/j.1365-3156.2010.02611.x.

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33

Tagajdid, Mohamed Rida, Safae Elkochri, Hicham Elannaz, Rachid Abi, and Idriss Lahlou Amine. "Epidemiological, Clinical and Virological Characteristics of Patients with Hepatitis C in Morocco." International Journal of Translational Medical Research and Public Health 4, no. 1 (2020): 30–36. http://dx.doi.org/10.21106/ijtmrph.126.

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Objectives: In Morocco, the exact and recent prevalence of Hepatitis C Virus (HCV) infection is not well-known, due to the lack of recent epidemiological studies of the general Moroccan population. The objective of this study was to determine the prevalence of HCV and to describe the epidemiological, clinical and virological characteristics of patients infected with HCV diagnosed at the Mohammed V Military Teaching Hospital in Rabat, Morocco.
 Methods: This was a prospective study, spread over a period of 3 years (April 2015 - April 2018). All patients with a positive anti-HCV serology we
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34

Okoh, G. R., H. M. Kazeem, G. S. N. Kia, and S. Mailafia. "Evaluation of Enzyme Linked Immuno-Sorbent Assay and Rapid Immuno-Diagnostic Test for Rabies Antigen Detection in Archived Dog Brain Tissues." Folia Veterinaria 62, no. 1 (2018): 18–24. http://dx.doi.org/10.2478/fv-2018-0003.

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Abstract Rabies urgently requires strengthening of new and existing diagnostic methodology in order to overcome the threat it poses. We evaluated the Enzyme Linked Immuno-Sorbent Assay (ELISA) and the Rapid Immunodiagnostic Test (RIDT) in detecting rabies viral antigens, comparing both tests with the Direct Fluorescent Antibody Test (DFAT) which is the gold standard in rabies diagnosis. Fifty dog brain tissues collected from the archives of the Central Diagnostic Laboratory, National Veterinary Research Institute, Vom, Nigeria, were utilized for this study. ELISA performed better than RIDT and
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35

Varghese, Tintu, Shainey Alokit Khakha, Sidhartha Giri, et al. "Rotavirus Strain Distribution before and after Introducing Rotavirus Vaccine in India." Pathogens 10, no. 4 (2021): 416. http://dx.doi.org/10.3390/pathogens10040416.

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In April 2016, an indigenous monovalent rotavirus vaccine (Rotavac) was introduced to the National Immunization Program in India. Hospital-based surveillance for acute gastroenteritis was conducted in five sentinel sites from 2012 to 2020 to monitor the vaccine impact on various genotypes and the reduction in rotavirus positivity at each site. Stool samples collected from children under 5 years of age hospitalized with diarrhea were tested for group A rotavirus using a commercial enzyme immunoassay, and rotavirus strains were characterized by RT-PCR. The proportion of diarrhea hospitalizations
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36

Arthamin, Maimun Zulhaidah, Nyi R. Wahidah, and Boy A. Sihite. "MIELOMA MULTIPEL NONSECRETORY (Nonsecretory Multiple Myeloma)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 22, no. 1 (2018): 99. http://dx.doi.org/10.24293/ijcpml.v22i1.1231.

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The incidence of non-secretory multiple myeloma ranged between 1−5% cases of plasma cell dyscrasia (PCD). In the developedcountries like in Europe, cases of MM ranged from 4.5 up to 6.0/100.000 population/year with a median age at diagnosis between63 and 70 years. A very rare disease with difficulties in diagnosis in the clinical practice is the main reason for reporting this case.A nonsecretory MM (MMNS) case was reported in a 36–year-old male with multiple osteolytic lesions and bone pain; whereas renalinsufficiency as well as anemia was not found. The protein electrophoresis result showed a
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Mohanty, Purabi. "HIV / AIDS at a glance – Legal and ethical aspects and scenario in the state of Odisha." IP International Journal of Forensic Medicine and Toxicological Sciences 7, no. 3 (2022): 73–76. http://dx.doi.org/10.18231/j.ijfmts.2022.017.

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Acquired immuno deficiency syndrome (AIDS) is a lethal epidemic which alarmingly decreases the body’s ability to combat disease resulting in susceptibility to infection. Human Immunodeficiency Virus (HIV)/ AIDS have now moved from being viewed solely as a public health issue to a human rights issue. The goal in this regard is now to strengthen the anti-discrimination and other protective laws that safeguard the vulnerable group. To ensure confidentiality and privacy of people living with AIDS, legal and ethical implications for the medical profession are discussed here.In this article, many as
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Arndts, Kathrin, Tayseer E. M. Elfaki, Michael J. Doenhoff, et al. "Distinct Schistosoma mansoni-Specific Immunoglobulin Subclasses Are Induced by Different Schistosoma mansoni Stages—A Tool to Decipher Schistosoma mansoni Infection Stages." Pathogens 11, no. 1 (2021): 19. http://dx.doi.org/10.3390/pathogens11010019.

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Despite the existence of an effective medication against schistosomiasis, the disease remains a major health problem in affected areas, especially for those lacking appropriate sanitary facilities. Moreover, treatment cannot prevent re-infection since it is only effective on adult schistosome worms. Previous retrospective studies in the Sudan have discovered unique immuno-epidemiological profiles in uninfected individuals and those positive for Schistosoma mansoni via polymerase chain reaction (PCR) but egg-negative and those with eggs in their stool. Expanding on these data, serum samples fro
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39

Otu, Akaninyene A., Ubong A. Udoh, Okokon I. Ita, Joseph P. Hicks, Ido Ukpeh, and John Walley. "Prevalence of Zika and malaria in patients with fever in secondary healthcare facilities in south-eastern Nigeria." Tropical Doctor 50, no. 1 (2019): 22–30. http://dx.doi.org/10.1177/0049475519872580.

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We describe the frequency of Zika and malaria among patients presenting with fever to secondary health facilities in Cross River State, Nigeria. Using a cross-sectional, stratified survey design, we randomly selected nine facilities and consecutively recruited 100 participants (aged ≥ 1 year) who presented with fever. On testing blood samples using Biocan qualitative lateral flow immuno-chromatographic cassettes for Zika IgG and IgM, 10% were seropositive for Zika virus (ZIKV) IgM, 12% for ZIKV IgG and 20% for ZIKV IgM, IgG or both. Following microscopy of thick films stained with Giemsa for m
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40

McKAY, D. M. "The beneficial helminth parasite?" Parasitology 132, no. 1 (2005): 1–12. http://dx.doi.org/10.1017/s003118200500884x.

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There is unequivocal evidence that parasites influence the immune activity of their hosts, and many of the classical examples of this are drawn from assessment of helminth infections of their mammalian hosts. Thus, helminth infections can impact on the induction or course of other diseases that the host might be subjected to. Epidemiological studies demonstrate that world regions with high rates of helminth infections consistently have reduced incidences of autoimmune and other allergic/inflammatory-type conditions. Here I review and assess the possible ways by which helminth infections can bl
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41

Drame, Papa M., Vincent Foumane, Patrick Besnard, et al. "Human Antibody Response to Anopheles gambiae Saliva: An Immuno-Epidemiological Biomarker to Evaluate the Efficacy of Insecticide-Treated Nets in Malaria Vector Control." American Journal of Tropical Medicine and Hygiene 83, no. 1 (2010): 115–21. http://dx.doi.org/10.4269/ajtmh.2010.09-0684.

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42

van Dorp, Christiaan H., Michiel van Boven, and Rob J. de Boer. "Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution." PLoS Computational Biology 10, no. 12 (2014): e1003899. http://dx.doi.org/10.1371/journal.pcbi.1003899.

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43

Weir, R. E., A. R. Morgan, W. J. Britton, C. R. Butlin, and H. M. Dockrell. "Development of a whole blood assay to measure T cell responses to leprosy: a new tool for immuno-epidemiological field studies of leprosy immunity." Journal of Immunological Methods 176, no. 1 (1994): 93–101. http://dx.doi.org/10.1016/0022-1759(94)90353-0.

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Petitjeans, Fabrice, Alain Geloen, Cyrille Pichot, Sandrine Leroy, Marco Ghignone, and Luc Quintin. "Is the Sympathetic System Detrimental in the Setting of Septic Shock, with Antihypertensive Agents as a Counterintuitive Approach? A Clinical Proposition." Journal of Clinical Medicine 10, no. 19 (2021): 4569. http://dx.doi.org/10.3390/jcm10194569.

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Mortality in the setting of septic shock varies between 20% and 100%. Refractory septic shock leads to early circulatory failure and carries the worst prognosis. The pathophysiology is poorly understood despite studies of the microcirculatory defects and the immuno-paralysis. The acute circulatory distress is treated with volume expansion, administration of vasopressors (usually noradrenaline: NA), and inotropes. Ventilation and anti-infectious strategy shall not be discussed here. When circulation is considered, the literature is segregated between interventions directed to the systemic circu
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Aubele, Michaela, Martin Werner, and Heinz Höfler. "Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas." Analytical Cellular Pathology 24, no. 2-3 (2002): 69–76. http://dx.doi.org/10.1155/2002/371680.

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The hypothetical multistep model of breast carcinogenesis suggests a transition from normal epithelium to invasive carcinoma via intraductal hyperplasia (without and with atypia) andin situcarcinoma. These presumptive precursor lesions are currently defined by their histological features, and their prognosis is imprecisely estimated from indirect epidemiological evidence. Cytogenetic and molecular‐genetic analysis of these lesions give evidence for an accumulation of various genetic alterations during breast tumorigenesis. Using immuno‐histochemistry overexpression of the c‐erbB‐2 oncogene was
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BOURKE, C. D., R. M. MAIZELS, and F. MUTAPI. "Acquired immune heterogeneity and its sources in human helminth infection." Parasitology 138, no. 2 (2010): 139–59. http://dx.doi.org/10.1017/s0031182010001216.

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SUMMARYSimilarities in the immunobiology of different parasitic worm infections indicate that co-evolution of humans and helminths has shaped a common anti-helminth immune response. However, recentin vitroand immuno-epidemiological studies highlight fundamental differences and plasticity within host-helminth interactions. The ‘trade-off’ between immunity and immunopathology inherent in host immune responses occurs on a background of genetic polymorphism, variable exposure patterns and infection history. For the parasite, variation in life-cycle and antigen expression can influence the effector
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Sparwasser, Tim, Venkateswaran Ganesh, and Mannan Baru. "Immune mechanisms mediated by Salmonella in ameliorating airway inflammation (P6031)." Journal of Immunology 190, no. 1_Supplement (2013): 120.16. http://dx.doi.org/10.4049/jimmunol.190.supp.120.16.

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Abstract Epidemiological data suggest protection from allergic diseases when exposed to infectious agents during early stages of life. As allergies are mainly characterized as an unchecked Th2 response, modulation of the immune responses by pathogens have been considered to be a major factor in mediating the protection. Recent evidences implicate a key role staged by immuno-regulatory mechanisms induced upon infection in ameliorating these allergic disorders. A longitudinal study had demonstrated the reduced frequency and incidence of asthma in children, who had a prior infection from Salmonel
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Lyudmila D. Panova, Lyudmila D. Panova Lyudmila D. Panova. "The role of multistraine probiotics in non-specific seasonal prevention of acute respiratory infections in children with recurrent URTI in organized teams." Meditsinskiy sovet = Medical Council, no. 1 (March 21, 2021): 220–26. http://dx.doi.org/10.21518/2079-701x-2021-1-220-226.

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Introduction. A broad evidence base of numerous randomized clinical trials and meta-analyses asserts the role of intestinal microbiota dysbiosis in the development of various diseases, including those of infectious origin, in infancy and later stages of life.Purpose. Assessment of the efficacy of a multi-strain immuno-probiotic during rehabilitation of frequently ill children visiting organized groups during the period of epidemiological distress for acute respiratory diseases.Materials and methods.93 children older than 3 years of age were enrolled in an open comparative prospective clinical
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Kitts, David D. "Bioactive substances in food: identification and potential uses." Canadian Journal of Physiology and Pharmacology 72, no. 4 (1994): 423–34. http://dx.doi.org/10.1139/y94-062.

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Bioactive substances in foods can represent "extranutritional" constituents naturally present in small quantities in the food matrix, produced upon either in vivo or industrial enzymatic digestion, the latter being a result of food-processing activities. Bioactive constituents of food evoke physiological, behavioral, and immunological effects. Evidence from both epidemiological and animal studies has suggested chemopreventative roles for phytochemicals in certain forms of cancers and in the control of hyperlipidemia. Secondary products of plant metabolism can modulate xenobiotic metabolizing a
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Kao, Cheng-Yuan, Li-Yin Hung, Ching-Yun Chang, Jae-Hyang Lim, Jian-Dong Li, and Reen Wu. "Enhancing host defense against bacterial pore-forming toxin by suppressing HMG-CoA reductase pathway in airway epithelial cells (112.13)." Journal of Immunology 188, no. 1_Supplement (2012): 112.13. http://dx.doi.org/10.4049/jimmunol.188.supp.112.13.

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Abstract Pneumolysin and α-hemolysin are the main pore-forming toxins known to play critical roles in bacterial pneumonia caused by the infections of Streptococcus pneumoniae and Staphylococcus aureus, respectively. Airway epithelia are the initial and the primary targets of these air-borne bacterial infections. Several epidemiological studies have linked the use of statin to the improvement in pneumonia outcomes, but the nature of the mechanism is still unknown. Using primary normal human bronchial epithelial (NHBE) cells and an immortalized normal bronchial epithelial cell line, HBE1, we con
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