Dissertations / Theses on the topic 'Immune response – Regulation'
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Dahal, Lekh Nath. "Soluble CTLA-4 and immune regulation." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=202565.
Full textMadera, Laurence. "Mechanisms of immune response regulation by innate defense regulator peptides." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43066.
Full textCheung, Ka-wa Benny. "Immune regulation in response to mycobacterial infection." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634206.
Full textCheung, Ka-wa Benny, and 張嘉華. "Immune regulation in response to mycobacterial infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634206.
Full textAlasoo, Kaur. "Regulation of gene expression in macrophage immune response." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/263855.
Full textLim, Andrew Yih-Fan. "Mechanisms of immune regulation in HIV disease." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0081.
Full textKällberg, Eva. "Regulation of the immune response; focusing on somatic hyper-mutation." Lund : Lund University, Dept. of Cell and Molecular Biology, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39071819.html.
Full textMehta, Ninad T. "Early Epigenetic Regulation of the Adaptive Immune Response Gene CIITA." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_theses/24.
Full textWheway, Julie Elizabeth School of Medicine UNSW. "The Y1 receptor for NPY: a novel regulator of immune cell function." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/25194.
Full textCheung, Ka-wa Benny, and 張嘉華. "Mechanism of Bacillus Calmette Guerin-induced immune response." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29488989.
Full textUtješanović, Nataša. "Neuropilin-1 in immune regulation and formation of immunological memory." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610593.
Full textDaniels, Brodie Belinda. "Molecular and cellular analysis of the interaction between soluble CD23 and CD11/CD18 integrins." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1217.
Full textPereira, Melanie Claire. "The molecular analysis of the interation surface between sCD23 and the B2-integrins, CD11b & CD11c." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1014734.
Full textKay, R. A. "The mucosal regulation of the systemic immune response to cholera toxin." Thesis, University of Edinburgh, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380413.
Full textLeggat, Jamie Alexander. "Innate immunity & CD8+ T lymphocyte regulation of the immune response." Thesis, King's College London (University of London), 2005. http://kclpure.kcl.ac.uk/portal/en/theses/innate-immunity--cd8-t-lymphocyte-regulation-of-the-immune-response(7795ae39-e852-4841-9d6d-18abc9ca849c).html.
Full textDíaz, de Ståhl Teresita. "Fcγ Receptors in the Immune Response." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1545.
Full textCirculating immune complexes play an important role in the modulation of antibody responses and in the pathogenesis of immune diseases. This thesis deals with the in vivo regulatory properties of antibodies and their specific Fc receptors.
The immunosuppressive function of IgG is used clinically, to prevent rhesus-negative women from becoming sensitized to rhesus-positive erythrocytes from the fetus. The mechanism behind this regulation is poorly understood but involvement of a receptor for IgG, FcγRII, has been suggested. It is shown in this thesis that IgG and also IgE induce immunosuppression against sheep erythrocytes to a similar extent both in mice lacking all the known Fc receptors as in wild-type animals. These findings imply that antibody-mediated suppression of humoral responses against particulate antigens is Fc-independent and that the major operating mechanism is masking of epitopes.
Immunization with soluble antigens in complex with specific IgG leads to an augmentation of antibody production. The cellular mechanism behind this control is examined here and it is found that the capture of IgG2a immune complexes by a bone marrow-derived cell expressing FcγRI (and FcγRIII) is essential. An analysis of the ability of IgG3 to mediate this regulation indicated that, in contrast, this subclass of IgG augments antibody responses independently of FcγRI (and FcγRIII). These findings suggest that distinct mechanisms mediate the enhancing effect of different subclasses of antibodies.
Finally, the contribution of FcγRIII was studied in the development of collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis in humans. It was discovered that while DBA/1 wild-type control mice frequently developed severe CIA, with high incidence, FcγRIII-deficient mice were almost completely protected, indicating a crucial role for FcγRIII in CIA.
The results presented here help to understand how immune complexes regulate immune responses in vivo and show that Fc receptors for IgG, if involved, could be new targets for the treatment of immune complex-related disorders.
Knight, Derek Andrew. "Preparation of a site-specific lymphotoxin- mutant to be used in protein characterization and receptor binding studies." CSUSB ScholarWorks, 1995. https://scholarworks.lib.csusb.edu/etd-project/987.
Full textSprong, Kaitlin. "Analysis of the interaction between recombinant human Beta2 integrin I-domains and CD23." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/d1021078.
Full textSouthern, Kristina L. "Phenotypic and functional characteristics of T-lymphocytes during the course of infection with leishmania major." Virtual Press, 1995. http://liblink.bsu.edu/uhtbin/catkey/941372.
Full textDepartment of Biology
Hall, Samuel Wittenoom. "Immunomodulation by Schistosoma mansoni larval products in the non-obese diabetic mouse." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648708.
Full textClutton, Genevieve Tyndale. "HIV-specific interleukin-10 responses and immune modulation." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589623.
Full textClarke, Jodie Louise, and n/a. "Regulation of Cytokines and Chemokines during Lung Infection with Nontypeable Haemophilus influenzae." University of Canberra. n/a, 2008. http://erl.canberra.edu.au./public/adt-AUC20081210.084252.
Full textGomes, Andreia Ferreira de Castro. "Regulation of lymphocyte activation and apoptosis in the immune response in multiple sclerosis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-910-2/.
Full textCook, Peter Charles. "Regulation of the immune response in mice following multiple infections with schistosoma mansoni." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516633.
Full textDe, Glanville Benjamin. "Activation and regulation of the innate immune system in response to Ureaplasma infection." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/73702/.
Full textMee, Edward. "Manipulation of the immune response to malaria antigens using bacterial-derived lipoproteins." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:c98c8f59-092d-482c-b159-6033b9844908.
Full textHuang, Zhi Hua. "Regulation of macrophage functions by polyunsaturated fatty acids /." Adelaide, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phh8743.pdf.
Full textAl, souhail Qasim Mohammed. "Characterization, regulation and biophysical studies of immune-related peptides from Manduca sexta." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/32618.
Full textBiochemistry and Molecular Biophysics Interdepartmental Program
Michael Kanost
Insects secrete antimicrobial peptides as part of the innate immune response. Most antimicrobial peptides from insects have antibacterial but not antifungal activity. We have characterized an antifungal peptide, diapausin-1 from hemolymph of a lepidopteran insect, Manduca sexta (tobacco hornworm). Diapausin-1 was isolated by size exclusion chromatography from hemolymph plasma of larvae that were previously injected with a yeast, Saccharomyces cerevisiae. Fractions containing activity against S. cerevisiae were analyzed by SDS-PAGE and MALDI-TOF MS/MS and found to contain a 45-residue peptide that was encoded by sequences identified in M. sexta transcriptome and genome databases. A cDNA for diapausin-1 was cloned from cDNA prepared from fat body RNA. Diapausin-1 is a member of the diapausin family of peptides, which includes members known to have antifungal activity. The M. sexta genome contains 14 genes with high similarity to diapausin-1, each with 6 conserved Cys residues. Diapausin-1 was produced as a recombinant protein in Escherichia coli. Purified recombinant diapausin-1 was active against S. cerevisiae, with IC₅₀ of 12 μM, but had no detectable activity against bacteria. Spores of some plant fungal pathogens treated with diapausin-1 had curled germination tubes or reduced and branched hyphal growth. Diapausin-1 mRNA level in fat body strongly increased after larvae were injected with yeast or with Micrococcus luteus. In addition, diapausin-1 mRNA levels increased in midgut and fat body at the wandering larval stage prior to pupation, suggesting developmental regulation of the gene. Our results indicate that synthesis of diapausin-1 is part of an antifungal innate immune response to infection in M. sexta. Biophysical analysis showed that diapausin-1 binds to the β-1,3 glucan component of the S. cerevisiae cell wall. A second insect peptide investigated in this project was M.sexta stress-response peptide 1(SRP1), an immune-related peptide upregulated under different stress conditions including immune-challenge. Preliminary results for NMR structure determination are presented. Most of the amino acid residue spin systems were assigned, and we determined the connectivities of many amino residues as a first step to solve the NMR structure. The circular dichroism spectrum of SRP1 indicates that the peptide lacks alpha-helical structure and may contain beta strands and turns.
Caesar, Joseph J. "Investigations into mechanisms of complement regulation and bacterial invasion of the innate immune response." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711641.
Full textGreen, Lisa J. "The production of IL-2, IL-4, and TNF-gas in murine leishmaniasis." Virtual Press, 1991. http://liblink.bsu.edu/uhtbin/catkey/774758.
Full textDepartment of Biology
Clary, Sara Reed. "The effects of nitrosoureas on Thymocyte differentiation and T cell activation." Thesis, Virginia Tech, 1990. http://hdl.handle.net/10919/41939.
Full textCoombes, Janine. "Interactions between regulatory T cells and dendritic cells in intestinal immune regulation." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670085.
Full textGroom, Joanna Ruth School of Medicine UNSW. "Loss of immune regulatory checkpoints in BAFF transgenic mice." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/27281.
Full textNg, Wan Fai. "The role of anergic T cells in the regulation of immune response in man." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406268.
Full textRoberts, Tara Laurine. "Cellular responses to immunostimulatory DNA /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18175.pdf.
Full textChen, Ting, and 陳楟. "Dendritic cell biology regulated by Epstein-Barr virus (EBV) and its associated tumors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B3138285X.
Full textFreitag, Lori Linn 1959. "EFFECT OF RECOMBINANT INTERLEUKIN 2 ON DAUDI CELL KILLING IN NEWBORNS." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276458.
Full textMautsa, Nicodemus. "Structural and functional characterisation of the protein inhibitor of activated STAT3 (PIAS3)." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1004050.
Full textRajsbaum, Ricardo. "Expression of TRIM genes in different immune cells and mechanism of regulation of their expression : implications for the immune response to pathogens." Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494626.
Full textJankord, Ryan D. "The influence of physical activity on cytokine production in healthy older males." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1236370.
Full textSchool of Physical Education
Ford, Megan. "The role and mechanism of B6/1pr TCRÃߧ+CD4§-CD8§- T cells in immune response regulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63098.pdf.
Full textKe, Qi. "Negative Regulation of Host Innate Immune Signaling and Response Pathways by Viral and Host Regulatory Factors." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470185159.
Full textGay, Gabrielle. "Subversion de la réponse immune de l'hôte par Toxoplasma gondii." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV029/document.
Full textAn early hallmark of Toxoplasma gondii infection is the rapid control of the parasite population by a potent multifaceted innate immune response that engages resident and homing immune cells along with pro- and counter-inflammatory cytokines. In this context, IFN-γ activates a variety of T. gondii–targeting activities in immune and nonimmune cells but can also con- tribute to host immune pathology. T. gondii has evolved mechanisms to timely counteract the host IFN-γ defenses by interfering with the transcription of IFN-γ–stimulated genes. We now have identified TgIST (T. gondii inhibitor of STAT1 transcriptional activity) as a critical molecular switch that is secreted by intracellular parasites and traffics to the host cell nucleus where it inhibits STAT1-dependent proinflammatory gene expression. We show that TgIST not only sequesters STAT1 on dedicated loci but also promotes shaping of a nonpermissive chromatin through its capacity to recruit the nucleosome remodeling deacetylase (NuRD) transcriptional repressor. We found that during mice acute infection, TgIST-deficient parasites are rapidly eliminated by the homing Gr1+ inflammatory monocytes, thus highlighting the protective role of TgIST against IFN-γ–mediated killing. By uncovering TgIST functions, this study brings novel evidence on how T. gondii has devised a molecular weapon of choice to take control over a ubiquitous immune gene expression mechanism in metazoans, as a way to promote long-term parasitism
MacKenzie, Jason Roderick. "The role of eosinophils in the regulation of CD4+ T helper 2 regulated inflammation /." View thesis entry in Australian Digital Theses Program, 2004. http://thesis.anu.edu.au/public/adt-ANU20051007.121844/index.html.
Full textMeng, Hui. "Regulation of Interferon-Inducible 2’-5’-Oligoadenylate Synthetases by Adenovirus VAI RNA." elsevier, 2012. http://hdl.handle.net/1993/11460.
Full textKaufman, Robin L. "Immunoregulation in myasthenia gravis." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/30683.
Full textMedicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
Szymczak, Wendy A. "The Role Of Chemokines and Dendritic Cells In Regulation of IL-4 and Fungal Immunity." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1266607502.
Full textWelsby, Iain. "PARP12, a novel interferon stimulated gene potentially involved in the control of protein translation and innate immunity." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209714.
Full textPARP12 is a protein that possesses three main domains: A putative RNA binding N-terminal domain composed of tandem CCCH zinc-fingers, a central WWE domain and a C-terminal PARP catalytic domain. In this work, we have shown that the expression of PARP12 is strictly-dependent on type-I interferons, that it possesses ADP-ribosyl transferase activity and that in can regulate the translation of messenger RNA into proteins. PARP12 can be found in stress granules, sites of storage of untranslated mRNAs, and is capable of directly inhibiting the translation of a reporter mRNA when tethered to it, in a manner dependent on its catalytic activity. Furthermore overexpression of wild-type PARP12, in contrast to overexpression of a mutant with no detectable catalytic activity (PARP12-G575W), leads to a general arrest of most cellular translation.
On the other hand, we have shown that PARP12 can activate the transcription of genes under the control of an NFκB-dependent promoter, especially when its zinc-fingers are deleted or mutated (PARP12ΔZnF). PARP12ΔZnF is located in structures that can enclose TRIF, RIP1, NEMO, p62/SQSTM1 and ubiquitin. These proteins have all possess an important role in the activation of NFκB signalling cascades. Moreover, we have shown that endogenous PARP12 is situated in ALIS (Aggresome-Like Induced Structures) in LPS-stimulated macrophages. These structures have a possible role in the presentation of antigens on class I major histocompatibility complexes, implying that PARP12 may be involved in the regulation of antigen presentation.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Debock, Isabelle. "Study of the development of Th17-type immune response in early life." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209700.
Full textRécemment, de nouveaux lymphocytes T auxiliaires ont été décrits, les lymphocytes Th17, producteurs d’IL-17A, d’IL-17F et d’IL-22, d’une part, et les lymphocytes Tfh, sécrétant de l’IL-21 et exprimant CXCR5, ICOS et PD-1, d’autre part. La différenciation des lymphocytes Th17 dépend de la présence d’IL-6 ou d’IL-21 et de TGF-β, et est inhibée par l’IL-4 ;tandis que les lymphocytes Tfh sont induits en présence d’IL-21, d’IL-6 et du répresseur transcriptionnel Bcl6. Alors que les lymphocytes Th17 sont associés à des réponses inflammatoires par le recrutement de neutrophiles, les lymphocytes Tfh aident les lymphocytes B à produire des anticorps de haute affinité.
L’objectif principal de notre travail est l’étude du développement potentiel de réponses de type Th17 chez le nouveau-né de souris soumis à une stimulation allogénique et au manque d’IL-4. De plus, l’existence potentielle de lymphocytes Tfh induits chez le nouveau-né immunisé avec un vaccin constitué d’ovalbumine de poulet et d’Alum, sera investiguée.
Dans notre modèle de tolérance néonatale, l’immunisation de nouveau-nés BALB/c à l’aide de cellules spléniques semi-allogéniques F1 (AJAX x BALB/c) induit une polarisation de type Th2, associée à l’établissement d’un chimérisme lymphoïde et à l’acceptation d’une greffe de peau présentant les alloantigènes rencontrés à la naissance. Des nouveau-nés soumis à cette immunisation allogénique et à la privation d’IL-4, réalisée par l’utilisation d’anticorps monoclonaux ou de souris IL-4-/-, rejettent de façon aiguë les greffons de peau et présentent une proportion réduite de cellules chimériques. Cette rupture de la tolérance néonatale est associée à l’inhibition de la réponse allospécifique de type Th2 et au développement de lymphocytes Th17 alloréactifs, produisant de l’IL-17A. L’inhibition de la voie Th17 ne conduit toutefois pas à l’acceptation des allogreffes de peau. Par contre, la neutralisation de l’IL-6 ou de l’IL-17A et la réduction du nombre de neutrophiles restaurent la proportion de cellules chimériques présentes dans la rate, démontrant que la réponse de type Th17 allospécifique néonatale contrôle le chimérisme lymphoïde.
En réponse au vaccin OVA-Alum, les nouveau-nés présentent une proportion accrue de lymphocytes Tfh CXCR5+ PD-1+, bien que cette proportion lymphocytaire soit significativement diminuée par rapport aux adultes. Les lymphocytes Tfh néonataux expriment en outre des taux moindres des ARNm d’IL-21, d’IL-4 et de Bcl6, suggérant que la génération de lymphocytes Tfh est altérée en début de vie. En parallèle, les titres et la maturation des anticorps produits suite à la vaccination sont réduits chez les nouveau-nés, en comparaison avec les adultes. Cependant, qu’ils soient déficients en IL-4 ou non, des lymphocytes T CD4+ néonataux activés in vitro en présence d’IL-6 induisent une production d’anticorps par des lymphocytes B compétents, suggérant qu’il n’y a pas de défaut intrinsèque des lymphocytes T du nouveau-né à développer une capacité d’aide aux lymphocytes B.
En conclusion, nous avons montré que la polarisation de type Th2 néonatale inhibe la différenciation de lymphocytes Th17 alloréactifs contrôlant le rejet de cellules allogéniques, un mécanisme pouvant intervenir dans la relation immunitaire entre la mère et l’enfant. Nos résultats indiquent également que le nouveau-né est capable de différencier des lymphocytes Tfh, bien que le développement de ces derniers semble réduit. \
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished
Busse, Matthew Schmidt. "Transcriptional regulation of antimicrobial peptide induction by NF-[kappa]B family members during the Drosophila melanogaster immune response." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3243870.
Full textTitle from first page of PDF file (viewed February 12, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 85-93).