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Journal articles on the topic 'Immune Impact'

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Author: Grafiati

Published: 1 April 2023

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1

Mahmood, Zaid Khawam. "Organizational Virtuousness and their Impact in Organizational Immune System: Analytical Research." Revista Gestão Inovação e Tecnologias 11, no. 3 (June 30, 2021): 771–84. http://dx.doi.org/10.47059/revistageintec.v11i3.1974.

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2

Maggiorani, Damien, and Christian Beauséjour. "Senescence and Aging: Does It Impact Cancer Immunotherapies?" Cells 10, no. 7 (June 22, 2021): 1568. http://dx.doi.org/10.3390/cells10071568.

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Cancer incidence increases drastically with age. Of the many possible reasons for this, there is the accumulation of senescent cells in tissues and the loss of function and proliferation potential of immune cells, often referred to as immuno-senescence. Immune checkpoint inhibitors (ICI), by invigorating immune cells, have the potential to be a game-changers in the treatment of cancer. Yet, the variability in the efficacy of ICI across patients and cancer types suggests that several factors influence the success of such inhibitors. There is currently a lack of clinical studies measuring the impact of aging and senescence on ICI-based therapies. Here, we review how cellular senescence and aging, either by directly altering the immune system fitness or indirectly through the modification of the tumor environment, may influence the cancer-immune response.

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3

Albonici, Loredana, Monica Benvenuto, Chiara Focaccetti, Loredana Cifaldi, Martino Tony Miele, Federica Limana, Vittorio Manzari, and Roberto Bei. "PlGF Immunological Impact during Pregnancy." International Journal of Molecular Sciences 21, no. 22 (November 18, 2020): 8714. http://dx.doi.org/10.3390/ijms21228714.

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During pregnancy, the mother’s immune system has to tolerate the persistence of paternal alloantigens without affecting the anti-infectious immune response. Consequently, several mechanisms aimed at preventing allograft rejection, occur during a pregnancy. In fact, the early stages of pregnancy are characterized by the correct balance between inflammation and immune tolerance, in which proinflammatory cytokines contribute to both the remodeling of tissues and to neo-angiogenesis, thus, favoring the correct embryo implantation. In addition to the creation of a microenvironment able to support both immunological privilege and angiogenesis, the trophoblast invades normal tissues by sharing the same behavior of invasive tumors. Next, the activation of an immunosuppressive phase, characterized by an increase in the number of regulatory T (Treg) cells prevents excessive inflammation and avoids fetal immuno-mediated rejection. When these changes do not occur or occur incompletely, early pregnancy failure follows. All these events are characterized by an increase in different growth factors and cytokines, among which one of the most important is the angiogenic growth factor, namely placental growth factor (PlGF). PlGF is initially isolated from the human placenta. It is upregulated during both pregnancy and inflammation. In this review, we summarize current knowledge on the immunomodulatory effects of PlGF during pregnancy, warranting that both innate and adaptive immune cells properly support the early events of implantation and placental development. Furthermore, we highlight how an alteration of the immune response, associated with PlGF imbalance, can induce a hypertensive state and lead to the pre-eclampsia (PE).

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4

Elkhal, Abdallah, Hector Rodriguez Cetina Biefer, and Miguel A. de la Fuente. "Impact of Metabolism on Immune Responses." Journal of Immunology Research 2018 (July 26, 2018): 1–2. http://dx.doi.org/10.1155/2018/5069316.

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5

Alegre, Maria‐Luisa. "Immune impact of commensals versus pathobionts." American Journal of Transplantation 20, no. 4 (March 28, 2020): 913. http://dx.doi.org/10.1111/ajt.15840.

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6

Conti, Pio, Lucia Tettamanti, Filiberto Mastrangelo, Gianpaolo Ronconi, Ilias Frydas, Spiros K. Kritas, Alessandro Caraffa, and Franco Pandolfi. "Impact of Fungi on Immune Responses." Clinical Therapeutics 40, no. 6 (June 2018): 885–88. http://dx.doi.org/10.1016/j.clinthera.2018.04.010.

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7

Tavasolian, F. "The Impact of Immune Cell-derived Exosomes on Immune Response Initiation and Immune System Function." Current Pharmaceutical Design 27, no. 2 (June 2021): 2545–57. http://dx.doi.org/10.2174/13816128mtey5mtqmy.

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8

Tavasolian, Fataneh. "The Impact of Immune Cell-derived Exosomes on Immune Response Initiation and Immune System Function." Current Pharmaceutical Design 27, no. 2 (2021): 197–205. http://dx.doi.org/10.2174/18734286mteyimtqcy.

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9

Jang, Jiyoung, Dae-Hyoun Lim, and In-Hong Choi. "The Impact of Nanomaterials in Immune System." Immune Network 10, no. 3 (2010): 85. http://dx.doi.org/10.4110/in.2010.10.3.85.

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10

Engelmann, Flora. "The Impact of Menopause on Immune Senescence." Open Longevity Science 6, no. 1 (June 2012): 101–11. http://dx.doi.org/10.2174/1876326x01206010101.

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11

Dwivedi, PremendraD, Anurag Tripathi, KausarM Ansari, Rishi Shanker, and Mukul Das. "Impact of Nanoparticles on the Immune System." Journal of Biomedical Nanotechnology 7, no. 1 (January 1, 2011): 193–94. http://dx.doi.org/10.1166/jbn.2011.1264.

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12

Gary Wheeler, J., Margaret L. Bogle, Sarah J. Shema, M. Annette Shirrell, Kimo C. Stine, Arlyn J. Pittler, A. Wesley Burks, and Ricki M. Helm. "Impact of Dietary Yogurt on Immune Function*." American Journal of the Medical Sciences 313, no. 2 (January 1997): 120–23. http://dx.doi.org/10.1016/s0002-9629(15)40069-2.

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13

Mundy, L. M., P. G. Auwaerter, D. Oldach, M. L. Warner, A. Burton, E. Vance, C. A. Gaydos, J. M. Joseph, R. Gopalan, and R. D. Moore. "Community-acquired pneumonia: impact of immune status." American Journal of Respiratory and Critical Care Medicine 152, no. 4 (October 1995): 1309–15. http://dx.doi.org/10.1164/ajrccm.152.4.7551387.

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14

Mountz, John D., and Hui-Chen Hsu. "Impact of immune senescence on human aging." Immunology and Allergy Clinics of North America 23, no. 1 (February 2003): xi—xv. http://dx.doi.org/10.1016/s0889-8561(02)00086-3.

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15

Hahn, J., M. Günter, and S. Autenrieth. "Impact of sleep on innate immune cells." Brain, Behavior, and Immunity 49 (October 2015): e43. http://dx.doi.org/10.1016/j.bbi.2015.06.162.

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Wheeler, J. Gary, Margaret L. Bogle, Sarah J. Shema, M. Annette Shirrell, Kimo C. Stine, Arlyn J. Pittler, A. Wesley Burks, and Ricki M. Helm. "Impact of Dietary Yogurt on Immune Function." American Journal of the Medical Sciences 313, no. 2 (February 1997): 120–23. http://dx.doi.org/10.1097/00000441-199702000-00011.

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17

Wolowczuk, Isabelle, Claudie Verwaerde, Odile Viltart, Anne Delanoye, Myriam Delacre, Bruno Pot, and Corinne Grangette. "Feeding Our Immune System: Impact on Metabolism." Clinical and Developmental Immunology 2008 (2008): 1–19. http://dx.doi.org/10.1155/2008/639803.

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Endogenous intestinal microflora and environmental factors, such as diet, play a central role in immune homeostasis and reactivity. In addition, microflora and diet both influence body weight and insulin-resistance, notably through an action on adipose cells. Moreover, it is known since a long time that any disturbance in metabolism, like obesity, is associated with immune alteration, for example, inflammation. The purpose of this review is to provide an update on how nutrients-derived factors (mostly focusing on fatty acids and glucose) impact the innate and acquired immune systems, including the gut immune system and its associated bacterial flora. We will try to show the reader how the highly energy-demanding immune cells use glucose as a main source of fuel in a way similar to that of insulin-responsive adipose tissue and how Toll-like receptors (TLRs) of the innate immune system, which are found on immune cells, intestinal cells, and adipocytes, are presently viewed as essential actors in the complex balance ensuring bodily immune and metabolic health. Understanding more about these links will surely help to study and understand in a more fundamental way the common observation that eating healthy will keep you and your immune system healthy.

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18

Hamada, Kazuyuki, Takuya Tsunoda, and Kiyoshi Yoshimura. "Emerging Immune-Monitoring System for Immune Checkpoint Inhibitors." Life 12, no. 8 (August 13, 2022): 1229. http://dx.doi.org/10.3390/life12081229.

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Immune checkpoint inhibitors (ICIs) have a major impact on cancer treatment. However, the therapeutic efficacy of ICIs is only effective in some patients. Programmed death ligand 1 (PD-L1), tumor mutation burden (TMB), and high-frequency microsatellite instability (MSI-high) are markers that predict the efficacy of ICIs but are not universally used in many carcinomas. The gut microbiota has received much attention recently because of its potential to have a significant impact on immune cells in the cancer microenvironment. Metabolites of the gut microbiota modulate immunity and have a strong influence on the therapeutic efficacy of ICI. It has been suggested that the gut microbiota may serve as a novel marker to predict the therapeutic efficacy of ICI. Therefore, there is an urgent need to develop biomarkers that can predict anti-tumor effects and adverse events, and the study of the gut microbiota is essential in this regard.

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19

M. Guirgis, Helmy. "The Impact of The Immune Check Point Duration of use on Cost in Lung Cancer." Pharmaceutics and Pharmacology Research 5, no. 6 (May 30, 2022): 01–05. http://dx.doi.org/10.31579/2693-7247/086.

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Background: Monotherapy and combinations of Pembrolizumab (Pembro), Atezolizumab (Atezo) and Cemiplimab (Cemi), prolonged overall survival (OS) in advanced/metastatic non-small cell lung cancer (a/m NSCLC). Pembro demonstrated 5-year OS gain. The duration of therapy of the immune check point inhibitors (ICI) has not been defined. One-year adjuvant Durvalumab (Durv) and Atezo significantly prolonged OS. Neoadjuvant few cycles resulted in positive outcomes. Costs are relatively expensive, multiplying with prolonged use. The estimated 2019 CAR-T cost was $450,000. The Affordable Insulin bill 6833 capping insulin monthly cost at $35 was approved by the U.S. House of Representative. There are unmet needs for coherent drug cost policies and containment. We aimed 1- Explore the factors which impact ICI costs in lung cancer stages 2- Navigate cost-saving strategy based on generics, therapy duration and monotherapy utilization thresholds at $450,000 and $550,000 for combinations Methods: Clinical studies outcomes were quoted. Annual drug prices were calculated. Results: Estimated annual Pemetrexed (Peme) costs were $113,793, generic chemicals < $1,000 and Bevacizumab (Bev) $150,126 vs $148,000, mean 6 ICI. Pembro 2-year costs were $334,652. The 3- $501,978 and 5- $836,630 were above the $450,000. Atezo + Bev+ Peme combination had the highest 2-year $722,977 costs, above $550,000. Atezo + Peme costs were $422,725, Pembro + Peme $448,445 and Cemi + Peme $425,385, not significantly different. Costs decreased by 25% using generics. Extending ICI use by 6-12 months increased combination costs by 25-50%. Adjuvant 1-year Durv costs were $148,013 and Atezo $154,446, half the 2-year. Using response rates, cost of neoadjuvant Nivolumab (Nivo) 2-4 cycles were $25,000 - $50,000. Conclusion: Generics, short ICI duration use, neo-adjuvants, and utilization thresholds reduced costs.

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20

Tingstedt, Jeanette Linnea, Malene Hove‐Skovsgaard, Julie Gaardbo, Henrik Ullum, Susanne Dam Nielsen, and Marco Gelpi. "The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation." APMIS 127, no. 7 (May 24, 2019): 529–37. http://dx.doi.org/10.1111/apm.12956.

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21

Moulin, Cristiane Martins, Ivo Marguti, Jean Pierre S. Peron, Luiz Vicente Rizzo, and Alfredo Halpern. "Impact of adiposity on immunological parameters." Arquivos Brasileiros de Endocrinologia & Metabologia 53, no. 2 (March 2009): 183–89. http://dx.doi.org/10.1590/s0004-27302009000200010.

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Studies evaluating immune function in obese humans and experimental animals indicate that the excess adiposity is associated with impaired in immune responses. Obesity is related to a higher rate of infections and to some types of cancer. Nutritional, metabolic and endocrine factors are implicated in the immunological changes. The adipose tissue directly produces substances with various functions related to immune system. Furthermore, some investigations suggest that certain types of weight reduction strategies can alter the immune function. Nevertheless, long-term studies should be carried out to address whether these changes positively affects the ability of these obese individuals to control infections and tumor development.

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22

Thibodeaux, Nicole, and Matt J. Rossano. "Meditation and Immune Function: The Impact of Stress Management on the Immune System." OBM Integrative and Complementary Medicine 3, no. 4 (July 16, 2018): 1. http://dx.doi.org/10.21926/obm.icm.1804032.

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23

R, Verma. "Understanding Emotional Roots of Human Immune System." Virology & Immunology Journal 5, no. 2 (April 1, 2021): 1–5. http://dx.doi.org/10.23880/vij-16000277.

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Decades of research has provided evidence that various psychological factors have a huge impact over the immune system which systematically stimulate it to give positive or negative responses and can time to time show several levels of modulations. These modulations or responses may enhance or may adversely affect the immune function of an individual. This review article focuses on affects and its roots to the human immune system, supported by various studies conducted in different times. The paper also discusses all the possible pathways by which emotion can connect with the immune function and vice-versa, how stress can affect the immune response as well as how the elements of psychological factors can modulate the immune function of an individual

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24

Hasan Huseyin Eker, Mehmet Derya Onuk, Caglayan Geredeli, and Maihebureti Abuduli. "THE IMPACT OF RAMAZAN I’TIKAF ON IMMUNE SYSTEM." Malaysian Journal of Public Health Medicine 17, no. 3 (December 31, 2017): 104–8. http://dx.doi.org/10.37268/mjphm/vol.17/no.3/art.221.

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I'tikaaf is a worship maintained by very deep hunger in fasting month of Ramadan. Hunger causes different results on the immune system. This is a prospective study. In this study, the changes in the immune system were investigated during the period of the i’tikaf, which is deep hunger worship. In the last 10 days of Ramadan, before and at the end of i’tikaf blood was taken from 46 male volunteers who performed i’tikaf worship and various biochemical and immunological parameters were examined. Comparison of the measures taken before and after i’tikaf indicated a statistically significant decrease in weight, BMI, waist circumference and hip circumference (p<0.001). Of the hematologic parameters, the lymphocyte count increased significantly (p=0.009). Also, a significant increase was observed in the values of IgA, IgM ve Ig G within the hematological parameters (p<0.001). During the period of i’tikaf, feeding with very low calories (1000 calories) caused an increase in the levels of lymphocyte and immunoglobulins and got the immune system stronger.

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25

Lambring, Christoffer B., Sohail Siraj, Krishna Patel, Umesh T. Sankpal, Stephen Mathew, and Riyaz Basha. "Impact of the Microbiome on the Immune System." Critical Reviews in Immunology 39, no. 5 (2019): 313–28. http://dx.doi.org/10.1615/critrevimmunol.2019033233.

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26

Chou, Wei-Chun, Elena Rampanelli, Xin Li, and Jenny P. Y. Ting. "Impact of intracellular innate immune receptors on immunometabolism." Cellular & Molecular Immunology 19, no. 3 (October 25, 2021): 337–51. http://dx.doi.org/10.1038/s41423-021-00780-y.

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AbstractImmunometabolism, which is the metabolic reprogramming of anaerobic glycolysis, oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has gained importance as a regulator of the homeostasis, activation, proliferation, and differentiation of innate and adaptive immune cell subsets that function as key factors in immunity. Metabolic changes in epithelial and other stromal cells in response to different stimulatory signals are also crucial in infection, inflammation, cancer, autoimmune diseases, and metabolic disorders. The crosstalk between the PI3K–AKT–mTOR and LKB1–AMPK signaling pathways is critical for modulating both immune and nonimmune cell metabolism. The bidirectional interaction between immune cells and metabolism is a topic of intense study. Toll-like receptors (TLRs), cytokine receptors, and T and B cell receptors have been shown to activate multiple downstream metabolic pathways. However, how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well understood. The goal of this review is to examine the link between immunometabolism and the functions of several intracellular innate immune sensors or receptors, such as nucleotide-binding and leucine-rich repeat-containing receptors (NLRs, or NOD-like receptors), absent in melanoma 2 (AIM2)-like receptors (ALRs), and the cyclic dinucleotide receptor stimulator of interferon genes (STING). We will focus on recent advances and describe the impact of these intracellular innate immune receptors on multiple metabolic pathways. Whenever appropriate, this review will provide a brief contextual connection to pathogenic infections, autoimmune diseases, cancers, metabolic disorders, and/or inflammatory bowel diseases.

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27

Mabrouk, Nesrine, Baptiste Lecoeur, Ali Bettaieb, Catherine Paul, and Frédérique Végran. "Impact of Lipid Metabolism on Antitumor Immune Response." Cancers 14, no. 7 (April 6, 2022): 1850. http://dx.doi.org/10.3390/cancers14071850.

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Over the past decade, metabolic reprogramming has been defined as a hallmark of cancer. More recently, a large number of studies have demonstrated that metabolic reprogramming can modulate the differentiation and functions of immune cells, and thus modify the antitumor response. Increasing evidence suggests that modified energy metabolism could be responsible for the failure of antitumor immunity. Indeed, tumor-infiltrating immune cells play a key role in cancer, and metabolic switching in these cells has been shown to help determine their phenotype: tumor suppressive or immune suppressive. Recent studies in the field of immunometabolism focus on metabolic reprogramming in the tumor microenvironment (TME) by targeting innate and adaptive immune cells and their associated anti- or protumor phenotypes. In this review, we discuss the lipid metabolism of immune cells in the TME as well as the effects of lipids; finally, we expose the link between therapies and lipid metabolism.

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28

Kinash, Maria, Oksana Boyarchuk, and Lesya Dobrovolska. "Zinc: its impact on immune function in children." Pediatria Polska 96, no. 4 (2021): 263–69. http://dx.doi.org/10.5114/polp.2021.112401.

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29

Norval, M. "The Impact of Ultraviolet Radiation on Immune Responses." Radiation Protection Dosimetry 91, no. 1 (September 2, 2000): 51–56. http://dx.doi.org/10.1093/oxfordjournals.rpd.a033234.

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30

Nagai, Taku, Daisuke Ibi, Toshitaka Nabeshima, Akira Sawa, and Kiyofumi Yamada. "Impact of perinatal immune activation on neuropsychological development." Neuroscience Research 68 (January 2010): e47-e48. http://dx.doi.org/10.1016/j.neures.2010.07.456.

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31

Medzhitov, Ruslan, and Charles A. Janeway. "Innate immunity: impact on the adaptive immune response." Current Opinion in Immunology 9, no. 1 (February 1997): 4–9. http://dx.doi.org/10.1016/s0952-7915(97)80152-5.

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32

Pagés, Franck, and Guido Kroemer. "Prognostic impact of anticancer immune responses: an introduction." Seminars in Immunopathology 33, no. 4 (May 28, 2011): 317–19. http://dx.doi.org/10.1007/s00281-011-0278-4.

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33

Wilder-Smith, A., F. B. Mustafa, A. Earnest, L. Gen, and P. A. MacAry. "Impact of partial sleep deprivation on immune markers." Sleep Medicine 14, no. 10 (October 2013): 1031–34. http://dx.doi.org/10.1016/j.sleep.2013.07.001.

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34

Young, M. Rita I., Kristin Kolesiak, Nicholas J. Achille, Eli Gonzalez, Shirley W. Liu, Tamara Wrone-Smith, Deanne M. R. Lathers, and Jeremy Meisinger. "Impact of aging on immune modulation by tumor." Cancer Immunology, Immunotherapy 50, no. 6 (August 1, 2001): 315–20. http://dx.doi.org/10.1007/s002620100203.

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35

SHEPHARD, ROY J., SHAWN RHIND, and PANG N. SHEK. "The Impact of Exercise on the Immune System." Exercise and Sport Sciences Reviews 23 (1995): 215???242. http://dx.doi.org/10.1249/00003677-199500230-00009.

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36

Ballieux, R. E. "Impact of mental stress on the immune response." Journal of Clinical Periodontology 18, no. 6 (July 1991): 427–30. http://dx.doi.org/10.1111/j.1600-051x.1991.tb02311.x.

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37

Scarpa, Marco, Andromachi Kotsafti, Matteo Fassan, Melania Scarpa, Francesco Cavallin, Teresa Nardi, Eleonora Pinto, et al. "Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms." Tumor Biology 39, no. 10 (October 2017): 101042831772868. http://dx.doi.org/10.1177/1010428317728683.

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38

Watanabe, H., T. Kubo, K. Kudo, D. Minami, T. Murakami, N. Ochi, T. Ninomiya, et al. "Impact of immune checkpoint inhibitors on subsequent chemotherapy." Annals of Oncology 28 (November 2017): x134. http://dx.doi.org/10.1093/annonc/mdx671.028.

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39

Khanferyan, Roman, I. Gmoshinski, S. Hotimchenko, N. Riger, E. Trushina, O. Mustafina, and Lawrence Dubuske. "Impact of Silica Nanoparticles on Rat Immune Responses." Journal of Allergy and Clinical Immunology 141, no. 2 (February 2018): AB124. http://dx.doi.org/10.1016/j.jaci.2017.12.393.

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40

Supali, Taniawati, Jaco J. Verweij, Aprilianto Eddy Wiria, Yenny Djuardi, Firdaus Hamid, Maria M. M. Kaisar, Linda J. Wammes, et al. "Polyparasitism and its impact on the immune system." International Journal for Parasitology 40, no. 10 (August 2010): 1171–76. http://dx.doi.org/10.1016/j.ijpara.2010.05.003.

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41

Gollomp, Kandace, and David T. Teachey. "TORing the impact of sirolimus on immune health." Blood 141, no. 3 (January 19, 2023): 212–14. http://dx.doi.org/10.1182/blood.2022018568.

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42

Aljabali, Alaa A., Mohammad A. Obeid, Rasha M. Bashatwah, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Mohamed El-Tanani, et al. "Nanomaterials and Their Impact on the Immune System." International Journal of Molecular Sciences 24, no. 3 (January 19, 2023): 2008. http://dx.doi.org/10.3390/ijms24032008.

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Nanomaterials have been the focus of intensive development and research in the medical and industrial sectors over the past several decades. Some studies have found that these compounds can have a detrimental impact on living organisms, including their cellular components. Despite the obvious advantages of using nanomaterials in a wide range of applications, there is sometimes skepticism caused by the lack of substantial proof that evaluates potential toxicities. The interactions of nanoparticles (NPs) with cells of the immune system and their biomolecule pathways are an area of interest for researchers. It is possible to modify NPs so that they are not recognized by the immune system or so that they suppress or stimulate the immune system in a targeted manner. In this review, we look at the literature on nanomaterials for immunostimulation and immunosuppression and their impact on how changing the physicochemical features of the particles could alter their interactions with immune cells for the better or for the worse (immunotoxicity). We also look into whether the NPs have a unique or unexpected (but desired) effect on the immune system, and whether the surface grafting of polymers or surface coatings makes stealth nanomaterials that the immune system cannot find and get rid of.

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43

Karpathiou, Georgia, Francois Casteillo, Jean-Baptiste Giroult, Fabien Forest, Pierre Fournel, Alessandra Monaya, Marios Froudarakis, Jean Marc Dumollard, Jean Michel Prades, and Michel Peoc'h. "Prognostic impact of immune microenvironment in laryngeal and pharyngeal squamous cell carcinoma: Immune cell subtypes, immuno-suppressive pathways and clinicopathologic characteristics." Oncotarget 8, no. 12 (December 27, 2016): 19310–22. http://dx.doi.org/10.18632/oncotarget.14242.

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44

Austin. "Impact of Human Immune Deficiency Virus and Acquired Immune Deficiency Syndrome on Farm Households." American Journal of Infectious Diseases 7, no. 2 (February 1, 2011): 32–39. http://dx.doi.org/10.3844/ajidsp.2011.32.39.

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45

Enke, Uta, Lydia Seyfarth, Ekkehard Schleussner, and Udo R. Markert. "Impact of PUFA on early immune and fetal development." British Journal of Nutrition 100, no. 6 (December 2008): 1158–68. http://dx.doi.org/10.1017/s000711450801413x.

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It has recently been reported that the increased prevalence in childhood allergy may be linked to deviations in fetal immune development. One reason may be impaired nutrient supply. Hence, a well-differentiated placenta together with an optimal fetal nutrition via the mother are important prerequisites for the establishment of a functional immune system with normal immune responses. Fatty acids and their derivatives can influence both the early immune development and immune maturation by regulating numerous metabolic processes and the gene expression of important proteins such as enzymes and cytokines. The present review summarises the impact of nutritional fatty acids on the development of the immune system as well as the fetal development. It describes the mechanisms of action of PUFA, trans fatty acids and conjugated linoleic acids in programming the fetus with regard to its risk of acquiring atopic diseases in childhood.

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46

Rousset-Rouviere, Sandrine, Philippe Rochigneux, Anne-Sophie Chrétien, Stéphane Fattori, Laurent Gorvel, Magali Provansal, Eric Lambaudie, Daniel Olive, and Renaud Sabatier. "Endometrial Carcinoma: Immune Microenvironment and Emerging Treatments in Immuno-Oncology." Biomedicines 9, no. 6 (June 2, 2021): 632. http://dx.doi.org/10.3390/biomedicines9060632.

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Endometrial cancer (EC) can easily be cured when diagnosed at an early stage. However, advanced and metastatic EC is a common disease, affecting more than 15,000 patients per year in the United Sates. Only limited treatment options were available until recently, with a taxane–platinum combination as the gold standard in first-line setting and no efficient second-line chemotherapy or hormone therapy. EC can be split into four molecular subtypes, including hypermutated cases with POLE mutations and 25–30% harboring a microsatellite instability (MSI) phenotype with mismatch repair deficiency (dMMR). These tumors display a high load of frameshift mutations, leading to increased expression of neoantigens that can be targeted by the immune system, including (but not limited) to T-cell response. Recent data have demonstrated this impact of programmed death 1 and programmed death ligand 1 (PD-1/PD-L1) inhibitors on chemo-resistant metastatic EC. The uncontrolled KEYNOTE-158 and GARNET trials have shown high response rates with pembrolizumab and dostarlimab in chemoresistant MSI-high tumors. Most responders experiment long responses that last more than one year. Similar, encouraging results were obtained for MMR proficient (MMRp) cases treated with a combination of pembrolizumab and the angiogenesis inhibitor lenvatinib. Approvals have, thus, been obtained or are underway for EC with immune checkpoint inhibitors (ICI) used as monotherapy, and in combination with antiangiogenic agents. Combinations with other targeted therapies are under evaluation and randomized studies are ongoing to explore the impact of ICI-chemotherapy triplets in first-line setting. We summarize in this review the current knowledge of the immune environment of EC, both for MMRd and MMRp tumors. We also detail the main clinical data regarding PD-1/PD-L1 inhibitors and discuss the next steps of development for immunotherapy, including various ICI-based combinations planned to limit resistance to immunotherapy.

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Zimmermann, Christian, and Anika E. Wagner. "Impact of Food-Derived Bioactive Compounds on Intestinal Immunity." Biomolecules 11, no. 12 (December 18, 2021): 1901. http://dx.doi.org/10.3390/biom11121901.

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The gastrointestinal system is responsible for the digestion and the absorption of nutrients. At the same time, it is essentially involved in the maintenance of immune homeostasis. The strongest antigen contact in an organism takes place in the digestive system showing the importance of a host to develop mechanisms allowing to discriminate between harmful and harmless antigens. An efficient intestinal barrier and the presence of a large and complex part of the immune system in the gut support the host to implement this task. The continuous ingestion of harmless antigens via the diet requires an efficient immune response to reliably identify them as safe. However, in some cases the immune system accidentally identifies harmless antigens as dangerous leading to various diseases such as celiac disease, inflammatory bowel diseases and allergies. It has been shown that the intestinal immune function can be affected by bioactive compounds derived from the diet. The present review provides an overview on the mucosal immune reactions in the gut and how bioactive food ingredients including secondary plant metabolites and probiotics mediate its health promoting effects with regard to the intestinal immune homeostasis.

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Tseng, Wen-Yi, Martin Stacey, and Hsi-Hsien Lin. "Role of Adhesion G Protein-Coupled Receptors in Immune Dysfunction and Disorder." International Journal of Molecular Sciences 24, no. 6 (March 13, 2023): 5499. http://dx.doi.org/10.3390/ijms24065499.

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Disorders of the immune system, including immunodeficiency, immuno-malignancy, and (auto)inflammatory, autoimmune, and allergic diseases, have a great impact on a host’s health. Cellular communication mediated through cell surface receptors, among different cell types and between cell and microenvironment, plays a critical role in immune responses. Selective members of the adhesion G protein-coupled receptor (aGPCR) family are expressed differentially in diverse immune cell types and have been implicated recently in unique immune dysfunctions and disorders in part due to their dual cell adhesion and signaling roles. Here, we discuss the molecular and functional characteristics of distinctive immune aGPCRs and their physiopathological roles in the immune system.

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Manz, Markus G. "Microbial Impact on Hematologic Homeostasis." Blood 120, no. 21 (November 16, 2012): SCI—40—SCI—40. http://dx.doi.org/10.1182/blood.v120.21.sci-40.sci-40.

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Abstract Abstract SCI-40 During systemic infection and inflammation, immune effector cells are in high demand and are rapidly consumed at sites of need. While adaptive immune cells have high proliferative potential, innate mature immune cells are mostly postmitotic and need to be replenished from bone marrow hematopoietic stem and progenitor cells. Indeed, severe clinical infection, particularly infections challenging the innate immune response, lead to an increase in hematopoietic differentiation and throughput in bone marrow, involving subsequent differentiation stages from hematopoietic stem cells, multipotent progenitors, as well as early-lineage and late-lineage restricted hematopoietic progenitors. A fundamental question is how the increased need is sensed and translated in enhanced production and how adequate levels of response are guided. Recent research has shed light on conserved intracellular and extracellular pathogen recognition receptors, such as Toll-like receptors, that are expressed on nonhematopoietic and hematopoietic effector cells and cause activation upon ligation. This activation results in production of hematopoietic growth, survival, activation, and migration factors operating at site on effector cells, but also at remote primary hematopoietic sites to increase production upon need. Recent research by several groups, including ours, surprisingly revealed that conserved pattern-recognition receptors are also expressed on hematopoietic stem and progenitor cells in bone marrow, implying a direct effect of systemically available ligands on these cellular populations. Indeed, it has been demonstrated that, for example, ligation of Toll-like receptor 4 by its cognate agonist lipopolysaccharide can lead to divisional activation, proliferation, lineage-directed differentiation, and migration of hematopoietic stem and lineage-restricted progenitor cells, all aimed at efficient contribution to immune responses and rapid reestablishment of hematopoietic homeostasis. The relative contribution of pathogen sensing by hematopoietic and diverse nonhematopoietic cells to appropriate hematopoietic responses, as well as the subcellular translation of the signals, is the focus of ongoing research. Also to be discussed will be how chronic infectious and inflammatory processes, which are frequently associated with aging, might impinge on hematopoiesis, potentially fostering hematopoietic stem cell diseases as exhaustion or transformation. Disclosures: No relevant conflicts of interest to declare.

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Tuchscherer, M., and G. Manteuffel. "Die Wirkung von psychischem Streß auf das Immunsystem. Ein weiterer Grund für tiergerechte Haltung (Übersichtsreferat)." Archives Animal Breeding 43, no. 6 (October 10, 2000): 547–60. http://dx.doi.org/10.5194/aab-43-547-2000.

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Abstract. Title of the paper: The effect of psycho stress on the immune System. Another reason for pursuing animal welfare (Review) Stress can be seen as the body's most important and complex reaction to ensure survival. Thus, stress must be considered a fundamentally positive type of adaptive reaction and concepts of stress have to be integral parts in considering animal well-being. It is widely recognized that acute and chronic stress have an impact on the neuroendocrine and immune system, the latter being of special interest with respect to health and welfare of animals. This review intends to provide an integrative approach to the complex relationships between stress, behaviour, neuroendocrine and immune system of farm animals. Physiological mechanisms that mediate the effects of stress on immune function including basic mechanisms of neuroendocrine-immune network and principles of immuno-modulation are presented and discussed in consideration of their practical impact for livestock production.

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