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Dissertations / Theses on the topic 'Immune Impact'

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Published: 1 April 2023

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1

Warnatsch, Annika. "Impact of proteasomal immune adaptation on the early immune response to viral infection." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16775.

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Im Kampf gegen eine Virusinfektion spielen CD8+ T Zellen des adaptiven Immunsystems eine besondere Rolle. Sie patroullieren im Körper und entdecken spezifische Virusepitope, welche mittels MHC Klasse I Molekülen auf der Oberfläche infizierter Zellen präsentiert werden. Wird eine virus-infizierte Zelle erkannt, kann diese schnell und effizient eliminiert. Für die Generierung viraler Peptide, welche auf MHC Klasse I Komplexe geladen werden, ist das Ubiquitin-Proteasom-System von essentieller Bedeutung. Kürzlich wurden weitere Funktionen des Immunoproteasoms aufgedeckt wie zum Beispiel der Schutz

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2

Kühl, Thomas. "Pathogenic impact of immune-related cells in Batten disease." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/pathogenic-impact-of-immunerelated-cells-in-batten-disease(ff86b71b-e859-4d91-a378-421eab71ae97).html.

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The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are inherited neurodegenerative diseases of children. In all types of NCL glial activation, the innate immune response of the brain, precedes neurodegeneration. However, it is unclear whether adaptive immune responses are also involved in these diseases, or if they directly contribute to disease pathogenesis. Therefore, we examined the role of adaptive immune cells in mouse models of Infantile NCL (Ppt1-/- mice) and Juvenile NCL (Cln3-/- mice) by identifying, localising, and subsequently genetically removing immune components. Charact

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3

Post, Frank A. "Mycobacterial strain diversity : impact on the host immune response." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/2717.

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4

Zhao, Wei. "Impact of the innate immune response on mammary epithelia." [Ames, Iowa : Iowa State University], 2009.

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5

Daniłowicz-Luebert, Emilia. "Impact of helminths and helminth products on immune responses." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16683.

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Helmintheninfektionen induzieren in ihren Wirten Typ 2 (Th2) Immunantworten, welche parasitäre Larvenstadien hemmen und/oder zur Abstoßung von intestinalen Würmern führen. Th2-Antworten können auch gegenüber Umweltallergenen ausgebildet werden und allergische Reaktionen vermitteln. Mastzellen (MZ) spielen eine herausragende Rolle für die Wirtsantwort gegen Parasiten. Die Ergebnisse der vorliegenden Arbeit zeigen, dass eine Infektion von MZ-defizienten Mäusen mit Helminthen zu einer reduzierten Produktion von IL-25, IL-33 und TSLP, einer beeinträchtigten Etablierung von Th2 Immunantworten und e

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6

Blaimer, Stephanie [Verfasser], and Edward K. [Akademischer Betreuer] Geissler. "Impact of innate and adaptive immune cells in tumor immune surveillance / Stephanie Blaimer ; Betreuer: Edward K. Geissler." Regensburg : Universitätsbibliothek Regensburg, 2020. http://d-nb.info/1210729202/34.

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7

Banerjee, Piu. "Immune mechanisms in atopic eczema and the impact of therapy." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391635.

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8

Pike, Lewis James. "Salmonella vaccines : the impact of antigenic location on immune responses." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313867.

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9

Weaver, Wade G. "Impact of VHSV M Protein on the Innate Immune System." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1481191320713471.

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10

Howells, Anwen. "The impact of innate immune cells on immunopathology in dengue." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:0a251372-4d0e-416d-ad3c-8e07e6729e1b.

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Dengue virus (DENV) is an arthropod-borne virus and has become a worldwide problem with steadily rising annual infection rates. Patients present with a range of symptoms from mild fever to, in some cases, life-threatening hemorrhagic fever and shock syndrome. The most severe cases require emergency hospital care and currently, there is no effective drug treatment or vaccine for dengue. As severe symptoms appear post-peak viremia, immuno-pathology is thought to be the cause and a potential trigger of this is differential activation of the immune response upon recognition of DENV. This could be

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11

Schlundt, Claudia. "Impact of the adaptive immune system in bone fracture healing." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18195.

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Knochengewebe besitzt die einzigartige Fähigkeit sich nach einem Bruch komplett zu regenerieren. Dennoch zeigen 10-15% der Patienten einen gestörten Heilungsverlauf. Das Immunsystem spielt eine entscheidende Rolle in der Frakturheilung. Im Rahmen der hier präsentierten Doktorarbeit wurde der Einfluss der CD4+ regulatorischen T-Zellen (Treg) auf die Knochenheilung untersucht. In einem Maus-Osteotomie-Modell wurde die zeitliche und räumliche Verteilung ausgewählter Immun- und Knochenzellen im osteotomierten Knochen untersucht. Dabei konnte gezeigt werden, dass Immunzellen im gesamten Heilungsver

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12

Anwar, S. "Impact of helminth infection on antimycobacterial immune responses in UK migrants." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/4398419/.

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Tuberculosis and helminth infections are co endemic in many parts of the world. This geographical overlap has led to the hypothesis that helminth infections could exacerbate the effects of Mycobacterium tuberculosis (Mtb) infection. Anthelmintic treatment has been observed to be associated with improved mycobacterial cellular responses and decreases in the frequency of Treg cells. The consequence of this immunomodulation may affect the ability of the host to restrict the growth of mycobacteria or mycobacterial killing. This study aims at investigating the modulations of the immune response pro

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13

Lascar, R. M. "Impact of human immunodeficiency virus on hepatitis B-specific immune responses." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445941/.

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Prior infection with hepatitis B virus (HBV) is a common occurrence in HIV infected subjects and an increasing cause of morbidity and mortality. The CD8 T cell response is crucial for the long-term control of the virus in patients resolving acute hepatitis B. I first examined the effect of HIV related immunodepletion on HBV-specific immune responses in patients who resolved HBV. A cross-sectional study showed a reduction in HBV-specific CD8 responses in HBV immune patients with HIV infection compared to those without. Longitudinal study of a subgroup of patients examined whether this attrition

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14

Burton, Catherine Teresa. "The impact of treatment strategies on immune responses in HIV-1 infection." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407980.

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15

Bartlett, David B. "Impact of physical activity on immune function and inflammation in the elderly." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5003/.

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Physiological ageing is accompanied with an increase in systemic inflammatory mediators (inflammageing), a functional decline of the immune system (immunesenescence), altered endocrine function (adrenopause) and reduced physical activity which predisposes the elderly to increased risk of disease. Little is known about the interplay between physical activity, inflammageing, adrenopause and immunesenescence and what impact interventions may have in the elderly. This thesis identified the consequences of inflammageing and its association with immunesenescence and the impact physical activity play

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Warnatsch, Annika [Verfasser], Richard [Akademischer Betreuer] Lucius, Hartmut [Akademischer Betreuer] Hengel, and Elke [Akademischer Betreuer] Krueger. "Impact of proteasomal immune adaptation on the early immune response to viral infection / Annika Warnatsch. Gutachter: Richard Lucius ; Hartmut Hengel ; Elke Krueger." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://d-nb.info/1037389131/34.

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Barry, Julianne Cecile. "Immune cell phenotype and function : impact of type 2 diabetes, obesity, and exercise." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/64071.

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McCabe, R. H. "Towards a predictive model for pollutant impact on marine invertebrate cellular immune function." Thesis, Swansea University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638040.

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The aim of this project was to develop predictive models for the impact of environmental pollution on marine invertebrate cellular immune function, through the analysis of the effects of season and selected organic chemicals on <I>Mytilus edulis </I>cellular immunity. In addition, the seasonal variation in <I>Arenicola marina </I>and <I>Asterias rubens </I>cellular immune function was studied to assess the suitability of these species as bioindicators of pollution. To achieve these aims, the blood cells of <I>M. edulis </I>and <I>A. marina </I>were initially classified into 3 and 5 subpopulati

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Neal, Stephanie Mary. "Adoptively transferred maternal colostral cells impact immune status and development in dairy calves." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/51629.

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Mortality and decreased weight gain resulting from infection and disease in dairy calves is a problem within the dairy industry. Colostrum is the sole source of maternal immunity for the calf, having a substantial impact on health and survival. To date, colostrum quality is determined by concentration of antibodies. Colostrum also contains proteins and cells, which may enhance immune development in the neonate. Our goals were to determine the impact of colostral immune cells on (1) immune status during the first month of life and (2) immune development over time. To determine the impact of ado

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Park, Myeongseon. "Dissecting the impact of macrophage migration inhibitory factor (MIF) on host immune response." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/97565.

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Macrophage migration inhibitory factor (MIF) has been implicated in mediating both innate and adaptive immune responses in inflammatory and infectious diseases. The sequence and structure of MIF is highly conserved across the avian phylogeny, which underlies high sequence homology and functional similarities between turkey and chicken MIFs. Turkey MIF (TkMIF) inhibited cell migration and promoted cell proliferation with production of inflammatory mediators, comparable to the biological properties of chicken MIF (ChMIF), thus indicating the biological cross-reactivity between turkey and chick

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21

Hellgren, Sofie. "Impact of cryopreservation and characterization of peripheral blood mononuclear cells and subsets in healthy donors by multicolor flow cytometry analysis." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413035.

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Introduction: Immune therapy plays a larger role in cancer treatment these days, but in order to find new therapies and improve already existing ones, more knowledge about the immune system is needed. The peripheral blood contains many different cell types, some extensively studied, some less well-known. By using multicolor flow cytometry, the immune status of an individual can be displayed in relatively short time. Aim: The aim of this study was to develop a multicolor flow cytometry method in order to examine the distribution of 31 cell types, with a focus on immune regulatory cells, in peri

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22

Lira, Pedro Israel Cabral de. "Impact of zinc supplementation on the morbidity and growth of low birthweight infants in northeast Brazil." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321777.

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23

Richey, Gary K. "The Impact of Psychosocial Variables on Immune System Functioning in a Sample of HIV-Positive Males." DigitalCommons@USU, 1992. https://digitalcommons.usu.edu/etd/6062.

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This study addressed the issue of the relationship between psychological well-being and immune function in a sample of HIV seropositive homosexual and bisexual males. A control group of HIV seronegative gay males was included. The study assessed the relationship between various psychological independent variables and immune system functioning over a 24-month time period for the seropositive subjects. Data on depression, coping style, psychosocial stress, and psychomatic symptoms were collected at baseline, as well as data on depression at 12 months and CD4 counts at 6-month intervals over a 2-

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24

Wu, Xi-Yang. "Studies on the impact of probiotic bacteria on enteric microbial diversity and immune response." Access electronically, 2006. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20061205.102712/index.html.

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25

Nóbrega, Cláudia Rubina Freitas Pereira de. "Infection of the thymus by micobacteria: potential impact on the immune response to infection." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/19397.

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Nóbrega, Cláudia Rubina Freitas Pereira de. "Infection of the thymus by micobacteria: potential impact on the immune response to infection." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/19397.

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27

Pieper, Natalia [Verfasser], та Annette [Akademischer Betreuer] Paschen. "Impact of IFN-γ resistance & MAPK inhibition on the immune surveillance of malignant melanoma - relevance for immune-based therapies / Natalia Pieper ; Betreuer: Annette Paschen". Duisburg, 2019. http://d-nb.info/1201274095/34.

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28

Nguyen, Trang Van. "Rotavirus vaccines and impact of maternal antibodies and cytokines on neonatal immune responses in swine." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1124135253.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xxv, 449 p.; also includes graphics (some col.). Includes bibliographical references (p. 376-449). Available online via OhioLINK's ETD Center

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Freund, Isabel [Verfasser], and Ralf [Akademischer Betreuer] Bartenschlager. "Impact of nucleotide modifications on immune stimulatory effects of RNA / Isabel Freund ; Betreuer: Ralf Bartenschlager." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177044579/34.

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30

Assmus, Lisa Mareike [Verfasser]. "Impact of chronic liver inflammation on adaptive immune responses to viral infection / Lisa Mareike Assmus." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1229989099/34.

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31

Ullah, Matti. "Immune Checkpoints in Peritoneal Carcinomatosis : HLA-G, PD-L1 & the Impact of Cancer Therapies." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS288.

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Carcinomatose péritonéale est un terme utilisé pour désigner la dissémination métastatique généralisée du cancer dans la cavité péritonéale. Il se caractérise par l’accumulation de liquide appelé « ascite » et est considéré comme étant au stade terminal du cancer, car il est difficile à traiter. L'ascite accumulée dans la PC comprend des cellules tumorales, cytokines et cellules immunitaires. Les cellules cancéreuses expriment des protéines spécifiques qui les aident à supprimer les cellules immunitaires et à survivre, appelées points de contrôle immunitaires. Des points de contrôle immunitair

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Arakelian, Tsolère. "Impact of Targeting the Autophagy Related Gene Beclin 1 on the Immune Landscape of Melanoma." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS193.

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L'immunothérapie basée sur le blocage des points de contrôle immunitaire (ICBs) est un traitement prometteur pour les patients atteints de mélanome ; cependant, seule une petite sous-population en tire un bénéfice à long terme. Un des défis pour améliorer l'efficacité et étendre le bénéfice des ICBs aux patients non répondeurs est de concevoir des approches innovantes permettant de transformer les tumeurs dites "froides ou désertes pour les cellules immunitaire" en tumeurs dites "chaudes ou infiltrées par les cellules immunitaires" qui sont éligibles aux ICBs. Nous avons étudié l'impact du cib

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Sjöberg, Veronika. "Immune response of the small intestinal mucosa in children with celiac disease : impact of two environmental factors, resident microbiota and oats." Doctoral thesis, Umeå universitet, Klinisk immunologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-71030.

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Celiac disease (CD) is an immune-mediated enteropathy caused by permanent intolerance to dietary gliadin in wheat gluten and related prolamines in barley and rye. The pathogenesis of CD is still unknown and several different environmental factors have been associated with CD, such as dysbiosis of the microflora. In this translational study we investigated the immune status and the interplay of T-cells and Tregs in the mucosa of children with CD and controls, as well as the immune status in treated CD patients, provoked by either dietary oats, CD associated bacteria or gluten. The major finding

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Gondorf, Fabian [Verfasser]. "Immune modulation by experimental filarial infection and its impact on E. coli-induced sepsis / Fabian Gondorf." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1080561307/34.

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35

Richards, Hannah Elizabeth. "Investigation of the impact of CD4+CD25+ regulatory T cells on immune responses induced in vivo." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54679/.

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CD4+CD25+ regulatory T cells (Treg) are known to inhibit T cell responses however their site of action and whether they suppress other immune responses has not been well characterised. Using a model of tumour rejection involving a melanoma cell line expressing Fas ligand (B16FasL) the effect of Treg on these responses has been studied. NK cells and macrophages were found to play a critical role in rejection of B16FasL. Depletion of Treg enhanced tumour rejection, whilst adoptive transfer of Treg inhibited tumour rejection, indicating that Treg suppress innate immune responses. Experiments perf

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36

Ibbett, Paul. "The impact of systemic immune system activation on the retina : implications for age-related macular degeneration." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/418420/.

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Age-related macular degeneration (AMD) is a neurodegenerative disease of the retina and the leading cause of blindness in the UK. Genetic studies and mouse models demonstrate a clear role for local immune activation in AMD pathology, but it is not clear whether systemic inflammation can contribute to AMD pathology. Systemic inflammation, particularly due to bacterial infection, has been shown to exacerbate neurodegeneration in Alzheimer’s and Prion disease. There is also evidence that patients who have been exposed to chronic bacterial infections (i.e. periodontitis, pneumonia) are at increase

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Ott, Christopher Philip. "Impact of Dietary Beta-glucan Supplementation on Performance and Immune Response of Broiler Chickens During Challenge." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/75170.

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Coccidiosis is a costly parasitic disease to the poultry industry with multiple prevention methods being explored to control its impact. One approach under development is the use of -glucans, which are carbohydrates from cell walls of various plant species. The first study evaluated the feeding effects of algae- derived -glucans on performance and responses of broilers during a coccidiosis challenge. Cobb 500 broilers (n=1280) were fed a control diet, control supplemented with 150 g/MT Algamune (BG), 100 g/MT Algamune ZPC (BGZn), or 0.01% Salinomycin (Sal). On d 15, challenged birds received m

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Dungey, Maurice. "Exercise in haemodialysis patients : impact on markers of inflammation." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/17157.

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End-stage renal disease patients have a greatly increased risk of cardiovascular disease partly attributed to the elevated levels of systemic inflammation observed in uraemia. One of the key mechanisms underlying inflammation appears to be the immune dysfunction that afflicts almost every aspect of the uraemic immune system. As a consequence patients experience immunosuppression and reduced responsiveness to antigen as well as a simultaneous over-activation leading to a pro-inflammatory environment. In addition, the haemodialysis (HD) treatment itself induces a proinflammatory response but may

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Balthazar, Monique Stephanie. "THE IMPACT OF POPULATION CHARACTERISTICS AND HEALTH BEHAVIORS ON THE IMMUNOLOGIC FUNCTION OF PEOPLES LIVING WITH HIV/AIDS IN A MIDWESTERN CITY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396649416.

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Povey, Sonia. "Eating for Resistance : The Impact of Macro-Nutrients on Immune Function and Pathogen Resistance in Spodoptera exempta." Thesis, Lancaster University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524768.

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Harre, Ulrike [Verfasser], and Falk [Akademischer Betreuer] Nimmerjahn. "The impact of IgG sialylation on the osteoclastogenic activity of immune complexes / Ulrike Harre. Gutachter: Falk Nimmerjahn." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1076399061/34.

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Tsai, Ming-Han Chloe. "The impact of HLA-driven escape mutation on viral replicative capacity and immune control in HIV infection." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:398b1b9b-c8e8-49db-826d-cdbc915317a8.

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Despite the introduction of antiretroviral therapy, the HIV/HIV epidemic remains an unsolved global health problem. Amongst all the host defence mechanisms, HLA class I molecules have shown the strongest genetic association with delayed disease progression, in particular HLA-B alleles. Numerous studies have shown that the HLAmediated CD8+ T cell responses play a central role in the immune control of HIV. Yet our understanding of HLA-mediated immune control of HIV remains incomplete, even when considering the best-defined epitopes restricted by the protective HLA alleles at a population level.

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Juarez, Molina Claudia Ivette. "Population-specific HLA impact in immune control of HIV in Mexico and non-Mexican HIV infected cohorts." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2a6242d2-91bf-4029-9067-a922cbf1d8e4.

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HIV-1 persists to be a major health problem worldwide. A prophylactic or therapeutic vaccine offers the best hope to restrain the HIV-1 epidemic, however a consistent correlate of immune protection is yet to be found. HLA class I expression and their restricting HIV-1 specific CD8+ T cell responses have been shown to play a vital role in the control of HIV-1 infection. The interactions between HIV-1 and CD8<sup>+</sup> T cell responses are complex and the mechanisms involved in the success or failure to control viraemia remain uncertain. Thus, the aim of these studies was to help define what C

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Wanjiku, Samuel Mburu. "Impact of inflammation-induced oxidative stress on the integrity of immuno-haematopoietic cells and potential ameliorating interventions in an in vitro HIV model." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95467.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Chronic inflammation and immune activation are hallmarks of HIV infection, resulting in chronic oxidative stress with over-utilization of antioxidant defences, which may contribute to the loss of immune cells and faster disease progression. Low levels of antioxidants in HIV- infected individuals have been associated with frequent opportunistic infections and an increased risk of mortality. HIV infection is also associated with on-going and aberrant activation of both the innate and adaptive immune systems. An important aspect of

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Mays, Jacqueline Wiesehan. "Psychosocial stress modulation of the murine anti-viral immune response during a primary influenza infection and the impact on immunologic memory." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1241712390.

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Chachage, Mkunde Seithy [Verfasser], and Michael [Akademischer Betreuer] Hoelscher. "Immune system modulation by infections with Helminths and HIV-1 : Impact on pathogen-specific T cellresponses, regulatory T cells and systemic immune activation / Mkunde Seithy Chachage. Betreuer: Michael Hoelscher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1049393228/34.

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Groh, Janos [Verfasser], and Rudolf [Akademischer Betreuer] Martini. "Pathogenic impact of immune cells in mouse models of neuronal ceroid lipofuscinosis / Janos Michael Groh. Betreuer: Rudolf Martini." Würzburg : Universitätsbibliothek der Universität Würzburg, 2013. http://d-nb.info/103768785X/34.

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Sam, Leila. "Impact of Parkinson’s Disease- Linked- Lrrk2 Mutation (Lrrk2G2019S) on the Innate Immune Response During Infection with Listeria Monocytogenes." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41190.

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Mutations in the Leucine-rich repeat kinase 2 (Lrrk2) gene are associated with familial and sporadic cases of Parkinson’s disease but are also found in inflammatory-related disorders such as Crohn’s disease, systemic lupus erythematosus, tuberculosis and leprosy. There is also evidence that LRRK2 is highly expressed in immune cells, particularly in macrophages, and has been functionally linked to pathways pertinent to immune cell function such as modulating the course of infections, cytokine release, autophagy and phagocytosis. Indeed, G2019S mutation in Lrrk2 is the most common mutation in Pa

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Hatmi, Saloua. "Impact du déficit hydrique sur les réponses de défense et la sensibilité de la vigne à Botrytis cinerea : rôle de la dégradation des polyamines." Thesis, Reims, 2013. http://www.theses.fr/2013REIMS035.

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Abstract:

La vigne est sujette à de nombreuses contraintes biotiques et abiotiques face auxquelles elle devra optimiser ses stratégies de défense, en favorisant parfois des interconnections entre les réponses adaptatives au stress abiotique et la gestion de la réponse immune face à un pathogène. Dans cette étude nous avons évalué l'effet du stress hydrique (par privation d'eau) sur différentes réactions adaptatives au stress, mais aussi sur des réponses de défense et sur la sensibilité des feuilles et des baies de la vigne à Botrytis cinerea. Ces réactions ont été suivies en utilisant des boutures végét

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Beckett, Amy Elizabeth. "Defining the impact of colonisation with Shiga toxin positive E. coli O157 on adaptive immunity in cattle." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33097.

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Abstract:

Shiga producing E. coli (STEC) O157 is a zoonotic pathogen. In humans STEC O157 causes bloody diarrhoea and potentially fatal renal failure. Cattle are the major reservoir, where bacteria are limited to the intestinal tract and do not cause clinical signs of disease. Previous studies indicate that shiga toxins produced by STEC O157, suppress STEC-specific cellular immune responses in vivo. This study aimed to initially examine the humoral immune response in cattle following natural challenge and the effects of a toxoid vaccination on this humoral STEC specific-immune response. We determined a

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