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1

Immune infertility: The impact of immune reactions on human infertility. Dordrecht: Springer Verlag, 2009.

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2

name, No. Basic biology and clinical impact of immunosenescence. Amsterdam: Elsevier, 2003.

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3

Baron, Ruth Ann. Gastrointestinal health, essential fatty acids & their impact on the immune system. Wood Dale, Il: Seroyal, 2001.

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4

Innate immune system of skin and oral mucosa: Properties and impact in pharmaceutics, cosmetics, and personal care products. Hoboken, N.J: John Wiley & Sons, 2011.

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5

Maes, Dominiek, Marina Sibila, and Maria Pieters, eds. Mycoplasmas in swine. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789249941.0000.

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Abstract This book contains 14 chapters that discuss the genetics, epidemiology, prevalence, pathogenesis, clinical signs, diagnosis, treatment, prevention and control of Mycoplasma infections in pigs. Chapter 1 discusses the phylogenetics and classification of Mycoplasma species in pigs; Chapter 2 describes the genomic diversity and antigenic variation of Mycoplasma hyopneumoniae strains; Chapter 3 discusses the pathogenesis, virulence factor and pathogenicity of Mycoplasma hyopneumoniae; Chapter 4 discusses the molecular epidemiology, risk factors, transmission and prevalence of Mycoplasma hyopneumoniae, Chapter 5 discusses the clinical signs and gross lesions of Mycoplasma hyopneumoniae infection; Chapter 6 discusses immune responses against Mycoplasma infections; Chapter 7 describes the interactions of Mycoplasma hyopneumoniae with other pathogens and their economic impact; Chapter 8 discusses the diagnosis of Mycoplasma hyopneumoniae infection and its associated diseases; Chapter 9 describes the general control measures against Mycoplasma hyopneumoniae infections; Chapter 10 describes the selection and efficacy of antimicrobials against Mycoplasma hyopneumoniae infections; Chapter 11 discusses the development and efficacy of vaccines against Mycoplasma hyopneumoniae; Chapter 12 describes the eradication of Mycoplasma hyopneumoniae in pig herds; Chapter 13 describes the epidemiology, prevalence, pathogenesis, clinical signs, diagnosis, treatment, prevention and control of Mycoplasma hyorhinis and Mycoplasma hyosynoviae in pig herds and Chapter 14 discusses the epidemiology, prevalence, transmission, pathogenesis, clinical signs, diagnosis, treatment, prevention, control and economic impact of Mycoplasma suis infection in pigs.
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6

Stoclet, Alain J. Immunes ab omni teloneo: Étude de diplomatique, de philologie et d'histoire sur l'exemption de tonlieux au haut Moyen Age et spécialement sur la praeceptio de navibus. Bruxelles: Institut historique belge de Rome, 1999.

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7

Office, General Accounting. AIDS education: Staffing and funding problems impair progress : report to the chairman, Committee on Governmental Affairs, U.S. Senate. Washington, D.C: U.S. General Accounting Office, 1989.

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8

Naz, Rajesh K., and Walter K. H. Krause. Immune Infertility: Impact of Immune Reactions on Human Fertility. Springer, 2016.

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9

Naz, Rajesh K., and Walter K. H. Krause. Immune Infertility: Impact of Immune Reactions on Human Fertility. Springer, 2018.

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10

Immune Infertility: The Impact of Immune Reactions on Human Infertility. Springer, 2009.

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11

Naz, Rajesh K., and Walter K. H. Krause. Immune Infertility: The Impact of Immune Reactions on Human Infertility. Springer, 2014.

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12

Impact of immune senescence on human aging. Philadelphia, Pa: Saunders, 2003.

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13

Pawelec, G. Basic Biology and Clinical Impact of Immunosenescence. Elsevier Science & Technology Books, 2003.

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14

Autophagy in Immune Response: Impact on Cancer Immunotherapy. Elsevier, 2020. http://dx.doi.org/10.1016/c2018-0-04795-7.

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15

Chouaib, Salem. Autophagy in Immune Response: Impact on Cancer Immunotherapy. Elsevier Science & Technology Books, 2020.

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16

Chouaib, Salem. Autophagy in Immune Response: Impact on Cancer Immunotherapy. Elsevier Science & Technology, 2020.

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17

Darrow, Pamela Rose. THE IMPACT OF AIDS ON FAMILY CAREGIVERS (IMMUNE DEFICIENCY). 1994.

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18

Corradetti, Bruna. Immune Response to Implanted Materials and Devices: The Impact of the Immune System on the Success of an Implant. Springer, 2016.

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19

Bressler, Jeanette Frieda. THE INSTITUTIONAL IMPACT AND APPROPRIATENESS OF AIDS NURSING HOME CARE (IMMUNE DEFICIENCY). 1992.

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20

B Cells: Molecular Biology, Developmental Origin and Impact on the Immune System. Nova Science Publishers, Incorporated, 2013.

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21

Corradetti, Bruna. The Immune Response to Implanted Materials and Devices: The Impact of the Immune System on the Success of an Implant. Springer, 2018.

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22

Schmidt-Weber, Carsten B. Allergy Prevention and Exacerbation: The Paradox of Microbial Impact on the Immune System. Springer, 2019.

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23

Schmidt-Weber, Carsten B. Allergy Prevention and Exacerbation: The Paradox of Microbial Impact on the Immune System. Springer, 2018.

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24

Fadhley, Christine. Side Effects of Antibiotics - What You Need to Know: Antibiotics' Impact on the Immune System. Independently Published, 2017.

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25

Yeruva, Laxmi, Daniel Munblit, and Maria Carmen Collado, eds. Impact of Early Life Nutrition on Immune System Development and Related Health Outcomes in Later Life. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88966-813-7.

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26

Cárdaba, Blanca, and Girolamo Pelaia, eds. Impact of System Biology and Molecular Medicine on the Management of Complex Immune Mediated Respiratory Diseases. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-544-2.

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27

Keen, Jessica. Malaria in pregnancy: Humoral immune mechanisms of protection, impact of HIV co-infection, and treatment options. 2006.

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28

Dayan, Nava, and Philip W. Wertz. Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products. Wiley & Sons, Incorporated, John, 2012.

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29

Dayan, Nava, and Philip W. Wertz. Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products. Wiley & Sons, Incorporated, John, 2011.

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30

Dayan, Nava, and Philip W. Wertz. Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products. Wiley & Sons, Incorporated, John, 2011.

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31

Altman, Gaylene Marie Bouska. THE IMPACT OF VALUES UPON COMFORT LEVELS OF NURSING STUDENTS IN CARING FOR PATIENTS WHO HAVE ACQUIRED IMMUNE DEFICIENCY SYNDROME OR WHO ARE POSITIVE FOR HUMAN IMMUNODEFICIENCY VIRUS (IMMUNE DEFICIENCY). 1992.

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32

Palmer, Jeffrey Scott. Deterministic mathematical models for the spread of Acquired Immune Deficiency Syndrome (AIDS): The qualitative impact of potential intervention strategies. 1990.

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33

Guenter, Peggi. THE IMPACT OF NUTRITIONAL STATUS AND HIV DISEASE PROGRESSION ON SURVIVAL IN PATIENTS WITH HIV INFECTION (IMMUNE DEFICIENCY, DISEASE PROGRESSION). 1993.

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34

Garbarino, Sergio. Morbidity, mortality, societal impact, and accident in sleep disorders. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0053.

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Sleep disorders are associated with several morbidities, most strongly with psychiatric disorders, cognitive impairment, and impaired quality of life, as well as with increased mortality. Sleep problems are common across the lifespan from childhood to adolescence and adulthood. Physiological sleep continuity with respect to circadian rhythms is considered to be important for the maintenance of cardiovascular, metabolic, and immune function, physiological homeostasis, and psychological balance. Nowadays, it is reasonable to include sleep disturbances among the top 10 potentially modifiable cardiovascular disease (CVD) risk factors. The links between sleep disorders and morbidity as CVD show bidirectional associations. Because these disorders are chronic, they may also have a deleterious societal impact on a patient’s employment status, ability to work, risk of accident, and health. The relationship between work performance and sleep quality is reciprocal and potentially complex. This chapter illustrates the principal sleep disorders and their relevance as indicators of health status.
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35

Wilkinson, MaryAnn. THE IMPACT OF NEUROLINGUISTIC PROGRAMMING RAPPORT SKILLS TRAINING FOR REGISTERED NURSES ON ONE ON ONE TEACHING OF ACQUIRED IMMUNE DEFICIENCY SYNDROME PREVENTION. 1988.

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36

McDonnell, Barbara Claire Schwarz. THE IMPACT OF THE AIDS EPIDEMIC ON UNIVERSITY STUDENTS AND THE ROLE OF THE NURSE IN CAMPUS HEALTH SERVICES IN THE EDUCATION/COUNSELING OF COLLEGE STUDENTS ABOUT AIDS (AIDS, IMMUNE DEFICIENCY). 1989.

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37

Roxburgh, Campbell S. D., and Donald C. McMillan. Cancer, immunity, and inflammation. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199656103.003.0012_update_001.

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The chapter focuses on the role of immunity and inflammation in established cancer. From the evidence reviewed it is clear that immune and inflammatory responses, innate, humoral and adaptive, local and systemic, are intimately linked to the tumour and themselves and impact on cancer survival. It is also possible to identify key mediators that may be targeted in the cancer patient. However, further work is required to elucidate the mechanisms by which these immune and inflammatory responses are activated, maintained, and interact. Therapeutic intervention using non-selective anti-inflammatory agents is widely advocated and likely to become part of routine clinical practice in the near future. Selective therapeutic intervention directed at the immune and inflammatory responses in cancer is in its infancy. Therefore, it would appear that, at least in non-hereditary disease, immune and inflammatory responses are of key, if not of prime, importance in tumour progression and dissemination.
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38

Volk, Hans-Dieter, and Levent Akyüz. Immunotherapy in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0055.

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Immunotherapy in critically-ill patients is only feasible at clinical experimental level; no therapy has been approved so far. To develop a potential therapeutic strategy we need to know the pathogen, immune status of the patient, and interaction between the particular pathogen and immune cells to readjust the patient´s individually imbalanced immunological responsiveness. Giving the right treatment at the right time is crucial for a better outcome and the best economic use of resources. The process starts by matching the therapeutic selection to the clinical need. Personalized immunotherapy, highly dependent on the available biomarker, is required. Future studies on new immunotherapeutic approaches in critically-ill patients can only be interpreted in combination with immunological biomarker analyses. Immune modulation is a promising approach despite many disappointing results and there is a clear need for immunological stratification of critically-ill patients for improved efficacy. The search continues for new clinical endpoints in surviving patients with medical and health-economical impact.
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39

Ali, Ased, and Rob Pickard. Infection of the lower urinary tract. Edited by Neil Sheerin. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0176_update_001.

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Lower urinary tract infection is common, distressing, and when recurrent can have a significant impact on quality of life. The normally sterile urinary tract is the site of an ongoing but complex interplay between an evolving pathogen and a highly developed host immune defence system. The development of an active infection generally requires either greater virulence in the pathogen or deficient host immune defence. Nonetheless, even where infection has occurred, the interplay between pathogen and host continues, influencing the extent and level of invasion as well as the duration of infection and extent of tissue damage caused.Asymptomatic bacteriuria is discussed, with implications for treatment (usually not). The risk factors, diagnosis and management of simple cystitis are discussed, with a discussion of approaches to managing recurrent infections. Urethritis requires consideration of sexually transmitted infections and co-infections. Prostatitis requires more prolonged antibiotic treatment.
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40

Bending, David, Kiran Nistala, and Lucy R. Wedderburn. Pathogenesis of juvenile idiopathic arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0060.

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Although the term juvenile idiopathic arthritis (JIA) encompasses a heterogeneous group of diseases, they all share a common pathological hallmark: inflammation of the synovium. Highly activated T cells, monocytes, and neutrophils are attracted to the joint and secrete mediators that not only perpetuate inflammation but also may attenuate immune regulation. In the oligoarticular and polyarticular forms of JIA, which are thought to be autoimmune conditions, dysregulated adaptive immunity is a likely factor in disease pathogenesis; the nature of the interactions between T effector (Teff) cells and T regulatory cells (Treg) is probably a key factor in controlling disease progression. Factors that affect the frequency and function of Tregs and/or the sensitivity of Teffs to mechanisms of immune suppression will therefore impact on the disease course. In the systemic form of JIA, however, dysregulation of innate immune pathways appears more central to disease pathogenesis resulting in augmented levels of interleukins IL-1β‎, IL-6, and IL-18. In the end, a final, common pathological pathway in JIA is the activation of monocytes and neutrophils, which are the principal mediators of joint inflammation and damage. This is supported by the fact that the therapies that have targeted innate cytokine pathways have shown greater success in the treatment of JIA.
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41

Tacchi, Mary Jane, and Jan Scott. 7. Depression in modern society. Oxford University Press, 2017. http://dx.doi.org/10.1093/actrade/9780199558650.003.0007.

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No age, gender, or social group is immune to depression and it is a very common human experience. ‘Depression in modern society’ considers the global impact of depression and how major international bodies, for example, the World Health Organization and World Bank, have tried to estimate the real world impact of depression and the economic costs to society. There is often great stigma associated with depression that may undermine a person’s willingness to access treatment. The lessons to be learned from campaigns that have tried to combat prejudice are considered along with the notion of genius and madness and whether there is evidence for an association between creativity and mood disorders.
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42

Cohen, Daniel A., and Asim Roy. Sleep and Neurological Disorders. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198778240.003.0010.

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Scientific investigation of the relationships between sleep and neurological disorders is at a relatively early stage. Damage to the nervous system or impaired neural development can cause a wide array of sleep disorders. In turn, sleep disruption may impair neuroplastic processes that are important for functional recovery after nervous system insults. Sleep disorders in patients with neurological disease can negatively affect quality of life for both the patients and the caregivers. Cardiovascular, metabolic, and immune process changes associated with sleep disorders may exacerbate the underlying neuropathological changes in neurological disease. Early intervention for sleep disorders in these patients may substantially improve neurological outcomes. More randomized, controlled treatment trials will ultimately help to determine the optimal timing and treatment modalities for the sleep disorders in these patients and the impact this will have on improving neurological health, enhancing neurological function, and reducing the care burden for this population.
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43

Macia, Laurence, Olivier Galy, and Ralph Kay Heinrich Nanan, eds. Modern Lifestyle and Health: How Changes in the Environment Impacts Immune Function and Physiology. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-146-5.

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44

Ajmal, Saira, and Zelalem Temesgen. Initiation of Antiretroviral Therapy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0020.

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The primary goal of therapy is to prevent HIV-associated morbidity and mortality. In addition to the dramatic decline in HIV-related illness and death that has been observed as a result of the introduction and expansion of combination antiretroviral therapy, evidence is emerging that uncontrolled HIV replication also has a deleterious impact on conditions that are not conventionally associated with immune deficiency. These conditions include cardiovascular disease, kidney disease, liver disease, neurologic complications, and malignancy. Studies have found an independent association between cumulative exposure to replicating virus over time and mortality. Emerging data also increasingly support the earlier use of ART.
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45

Keshav, Satish, and Alexandra Kent. Immunology and genetics in gastrointestinal and hepatic medicine. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0196.

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The gut has a pivotal role in immune homeostasis. It is constantly exposed to a wide array of antigens in food, and resident and consumed microorganisms. It is estimated that the number of bacterial cells in the gastrointestinal tract is tenfold greater than the number of cells in the human body. The gut needs to recognize harmful bacteria, and consequently contains the largest number of immune cells in the body. However, it must remain tolerant to commensal bacteria. Bacteria express antigens that stimulate an immunological response via the gut-associated lymphoid tissue (GALT). The GALT includes the appendix, tonsils, Peyer’s patches, and mesenteric lymph nodes. Therefore, the intestinal immune system is finely balanced between tolerance and reactivity. An example of an abnormal response that generally the individual should be tolerant to is gliadin peptides in coeliac disease. An example of excessive tolerance to an otherwise controllable infection is cryptosporidiosis, which causes diarrhoea in patients with HIV infection. The understanding of genetics in disease has progressed rapidly with the introduction of genome-wide association studies. The Welcome Trust Case Control Consortium has performed extensive research on the genetics of many illnesses, including Crohn’s disease, ulcerative colitis, Barrett’s oesophagus, oesophageal adenocarcinoma, and primary biliary cholangitis. Although these studies have increased our understanding of the molecular basis of disease, they have had little impact on clinical management. This may change as studies associate genotype and phenotype. Several gastrointestinal diseases have an etiology based on immunological or genetic aberrations, and these immunological mechanisms and genetic mutations can be utilized for diagnostic purposes. However, there is no genetic or immunological marker that is 100% specific to a disease and, consequently, the markers are used to support clinical, histological, and/or radiological findings.
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46

Verschuur, Gerrit L. Impact! Oxford University Press, 1996. http://dx.doi.org/10.1093/oso/9780195101058.001.0001.

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Most scientists now agree that some sixty-five million years ago, an immense comet slammed into the Yucatan, detonating a blast twenty million times more powerful than the largest hydrogen bomb, punching a hole ten miles deep in the earth. Trillions of tons of rock were vaporized and launched into the atmosphere. For a thousand miles in all directions, vegetation burst into flames. There were tremendous blast waves, searing winds, showers of molten matter from the sky, earthquakes, and a terrible darkness that cut out sunlight for a year, enveloping the planet in freezing cold. Thousands of species of plants and animals were obliterated, including the dinosaurs, some of which may have become extinct in a matter of hours. In Impact, Gerrit L. Verschuur offers an eye-opening look at such catastrophic collisions with our planet. Perhaps more important, he paints an unsettling portrait of the possibility of new collisions with earth, exploring potential threats to our planet and describing what scientists are doing right now to prepare for this awful possibility. Every day something from space hits our planet, Verschuur reveals. In fact, about 10,000 tons of space debris fall to earth every year, mostly in meteoric form. The author recounts spectacular recent sightings, such as over Allende, Mexico, in 1969, when a fireball showered the region with four tons of fragments, and the twenty-six pound meteor that went through the trunk of a red Chevy Malibu in Peekskill, New York, in 1992 (the meteor was subsequently sold for $69,000 and the car itself fetched $10,000). But meteors are not the greatest threat to life on earth, the author points out. The major threats are asteroids and comets. The reader discovers that astronomers have located some 350 NEAs ("Near Earth Asteroids"), objects whose orbits cross the orbit of the earth, the largest of which are 1627 Ivar (6 kilometers wide) and 1580 Betula (8 kilometers). Indeed, we learn that in 1989, a bus-sized asteroid called Asclepius missed our planet by 650,000 kilometers (a mere six hours), and that in 1994 a sixty-foot object passed within 180,000 kilometers, half the distance to the moon. Comets, of course, are even more deadly. Verschuur provides a gripping description of the small comet that exploded in the atmosphere above the Tunguska River valley in Siberia, in 1908, in a blinding flash visible for several thousand miles (every tree within sixty miles of ground zero was flattened). He discusses Comet Swift-Tuttle--"the most dangerous object in the solar system"--a comet far larger than the one that killed off the dinosaurs, due to pass through earth's orbit in the year 2126. And he recounts the collision of Comet Shoemaker-Levy 9 with Jupiter in 1994, as some twenty cometary fragments struck the giant planet over the course of several days, casting titanic plumes out into space (when Fragment G hit, it outshone the planet on the infrared band, and left a dark area at the impact site larger than the Great Red Spot). In addition, the author describes the efforts of Spacewatch and other groups to locate NEAs, and evaluates the idea that comet and asteroid impacts have been an underrated factor in the evolution of life on earth. Astronomer Herbert Howe observed in 1897: "While there are not definite data to reason from, it is believed that an encounter with the nucleus of one of the largest comets is not to be desired." As Verschuur shows in Impact, we now have substantial data with which to support Howe's tongue-in-cheek remark. Whether discussing monumental tsunamis or the innumerable comets in the Solar System, this book will enthrall anyone curious about outer space, remarkable natural phenomenon, or the future of the planet earth.
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47

Mascaro, Jennifer S., Lobsang Tenzin Negi, and Charles L. Raison. Cognitively Based Compassion Training. Edited by Emma M. Seppälä, Emiliana Simon-Thomas, Stephanie L. Brown, Monica C. Worline, C. Daryl Cameron, and James R. Doty. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780190464684.013.19.

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Recent research has examined the beneficial impact of kindness-based meditation practices, including cognitively-based compassion training (CBCT). Here we provide a theoretical and practical account of CBCT and review the emerging evidence that it affects the brain and body in ways that are relevant for health. Initial research demonstrated that CBCT alters immune function and stress physiology, and augments empathy as well as the neural activity supporting it. More recent studies indicate that CBCT is differentially effective, depending on the population that practices. We suggest directions for future research to best examine the apparently complex effects of CBCT on health and well-being.
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48

Blumberg, Emily A. Introduction. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199938568.003.0400.

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This chapter discusses the infections in patients receiving immunosuppressive drugs. Immunosuppressive medications are a mainstay of treatment for diverse immunologically mediated conditions. The impact of these medications on the risk for infection is variable and sometimes difficult to determine. Immunosuppressive agents can be divided into a heterogeneous set of classes with unique effects on the immune system; the risks for infections reflect the specific immunological perturbation associated with the medication. Currently, guidelines have been published recommending specific preventive measures to limit the likelihood that these immunosuppressive agents will be associated with infection. The chapter concludes that future study will be important to develop algorithms to define risk and specify appropriate preventive interventions.
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49

Yang, Jingduan, and Daniel A. Monti. Modern Studies of Acupuncture. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190210052.003.0019.

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This chapter presents some examples of modern research on acupuncture. They include studies on the physiological nature of acupuncture points and of acupuncture’s impact on the functions of the immune, endocrine, nerve, cardiovascular, digestive, respiratory, and reproductive systems. It also includes examples of clinical studies on the safety and efficacy of acupuncture on various clinical medical and psychiatric conditions such as asthma, infertility, gastroesophageal reflux disorder (GERD), endometriosis, chronic pain, depression, anxiety, and insomnia. It discusses the confusion in research conclusions caused by methodological deficits in study designs and interventions, and it initiates a discussion on the future direction of studies that benefit advances in modern medicine rather than judging acupuncture using pharmaceutical models of research that are unable to visualize and measure human energy.
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50

Chokroverty, Sudhansu, and Sushanth Bhat. Physiological changes in sleep. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0006.

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It is important for clinicians to be conversant with the physiological changes that occur in various organ systems during sleep, and the impact that sleep fragmentation and sleep deprivation have on the normal functioning of these systems. This chapter therefore strives to provide a brief overview of the physiological changes associated with sleep that occur in the central nervous system (CNS), the autonomic nervous system (ANS), the neuromuscular system, the respiratory system (including changes in the control of breathing during various stages of sleep) and cardiovascular systems, the gastrointestinal tract, the endocrine system, and the systems controlling thermoregulation and immune regulation. Additionally, the mechanisms underlying muscle hypotonia in sleep, as well as sleep-related changes in cerebral blood flow and cytokine function are discussed.
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