Relevant bibliographies by topics / Immune diversification

Academic literature on the topic 'Immune diversification'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Immune diversification"

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Sercarz, Eli E. "Immune focusing vs diversification and their connection to immune regulation." Immunological Reviews 164, no. 1 (August 1998): 5–10. http://dx.doi.org/10.1111/j.1600-065x.1998.tb01202.x.

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Radic, Marko Z., and Moncef Zouali. "Receptor Editing, Immune Diversification, and Self-Tolerance." Immunity 5, no. 6 (December 1996): 505–11. http://dx.doi.org/10.1016/s1074-7613(00)80266-6.

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de Villartay, Jean-Pierre, Alain Fischer, and Anne Durandy. "The mechanisms of immune diversification and their disorders." Nature Reviews Immunology 3, no. 12 (December 2003): 962–72. http://dx.doi.org/10.1038/nri1247.

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Borkowsky, William, Elizabeth J. McFarland, Ram Yogev, Yonghua Li, and Paul Harding. "Correlation of HIV-Specific Immunity, Viral Control, and Diversification following Planned Multiple Exposures to Autologous HIV in a Pediatric Population." Clinical and Vaccine Immunology 18, no. 10 (August 3, 2011): 1628–31. http://dx.doi.org/10.1128/cvi.05176-11.

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ABSTRACTRepeated controlled exposure to autologous virus was previously shown to result in increased CD8 T lymphocyte response to HIV antigens and accompanying reduction in viremia. We attempted to see if this immunity contributed to virologic control by correlating the immune response with quasispecies envelope diversification, an indicator of immune selection. The greatest diversification was seen in those with the greatest reduction in viremia but was unrelated to the frequency of Env-specific gamma interferon-producing cells. There was a trend toward correlation between the response to multiple HIV antigens and diversification.
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Milstein, C. "From antibody structure to immunological diversification of immune response." Science 231, no. 4743 (March 14, 1986): 1261–68. http://dx.doi.org/10.1126/science.3080810.

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Mamula, Mark J., and Charles A. Janeway. "Do B cells drive the diversification of immune responses?" Immunology Today 14, no. 4 (April 1993): 151–52. http://dx.doi.org/10.1016/0167-5699(93)90274-o.

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Hughes, Austin L. "Natural selection and the diversification of vertebrate immune effectors." Immunological Reviews 190, no. 1 (December 2002): 161–68. http://dx.doi.org/10.1034/j.1600-065x.2002.19012.x.

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Veillette, André. "Introduction: Signaling and signal diversification in antigen‐specific immune cells." Immunological Reviews 291, no. 1 (August 12, 2019): 5–7. http://dx.doi.org/10.1111/imr.12795.

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Pasquier, Louis Du. "Germline and somatic diversification of immune recognition elements in Metazoa." Immunology Letters 104, no. 1-2 (April 2006): 2–17. http://dx.doi.org/10.1016/j.imlet.2005.11.022.

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Wang, C., M. A. Bogue, D. B. Roth, and K. Meek. "Normal junctional diversification of immune receptors in p53-deficient mice." Journal of Immunology 159, no. 2 (July 15, 1997): 757–62. http://dx.doi.org/10.4049/jimmunol.159.2.757.

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Abstract One of the strategies that the immune system utilizes to generate Ab and TCR diversity is programmed imprecision of coding joint formation. This is accomplished by both nucleotide loss and random nucleotide addition (N segments) to the termini of immune receptor coding segments before resolution. Although it has been known for more than a decade that terminal deoxynucleotidyl transferase is the enzyme responsible for N segment addition, the enzymes responsible for nucleotide loss have not been identified. Recently, the p53 tumor suppressor protein was shown to have an intrinsic exonuclease activity; we reasoned that p53 as an exonuclease might be responsible for coding end processing during V(D)J recombination. Thus, we examined nucleotide loss from Ig and TCR-beta coding joints in mice lacking p53. We find no significant difference in the degree of nucleotide loss in coding joints isolated from these animals as compared with littermate controls. Thus, we conclude that p53 does not play a role in removal of nucleotides from coding termini during V(D)J recombination. Additionally, recent evidence has surfaced suggesting that p53 may play an important checkpoint role in early thymocyte differentiation. More specifically, it has been suggested that p53 is required to prevent thymocytes from maturing to the double-positive stage in the absence of a functionally rearranged TCR-beta allele. Our data suggest that TCR-beta selection is not affected in p53-deficient, V(D)J rearrangement-proficient mice.
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Dissertations / Theses on the topic "Immune diversification"

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Marin, Frédéric. "Diversification du répertoire génomique immun chez le mouton : analyse moléculaire du segment Vl et étude de sa possible implication sur le mécanisme de diversification somatique du répertoire B, première exploration du "locus" H et du processus dediversificatiom qui y opère." Paris 5, 1993. http://www.theses.fr/1993PA05P230.

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Munshaw, Supriya Shaunak. "Computational Methods to Study Diversification in Pathogens, and Invertebrate and Vertebrate Immune Systems." Diss., 2010. http://hdl.handle.net/10161/2429.

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Pathogens and host immune systems use strikingly similar methods of diversification. Mechanisms such as point mutations and recombination help pathogens escape the host immune system and similar mechanisms help the host immune system attack rapidly evolving pathogens. Understanding the interplay between pathogen and immune system evolution is crucial to effective drug and vaccine development. In this thesis we employ various computational methods to study diversification in a pathogen, an invertebrate and a vertebrate immune system.

First, we develop a technique for phylogenetic inference in the presence of recombination based on the principle of minimum description length, which assigns a cost-the description length-to each network topology given the observed sequence data. We show that the method performs well on simulated data and demonstrate its application on HIV env gene sequence data from 8 human subjects.

Next, we demonstrate via phylogenetic analysis that the evolution of repeats in an immune-related gene family in Strongylocentrotus purpuratus is the result of recombination and duplication and/or deletion. These results support the evidence suggesting that invertebrate immune systems are highly complex and may employ similar mechanisms for diversification as higher vertebrates.

Third, we develop a probabilistic model of the immunoglobulin (Ig) rearrangement process and a Bayesian method for estimating posterior probabilities for the comparison of multiple plausible rearrangements. We validate the software using various datasets and in all tests, SoDA2 performed better than other available software.

Finally, we characterize the somatic population genetics of the nucleotide sequences of >1000 recombinant Ig pairs derived from the blood of 5 acute HIV-1 infected (AHI) subjects. We found that the Ig genes from the 20 day AHI PC showed extraordinary clonal relatedness among themselves; a single clone comprised of 52 members, with observed and inferred precursor antibodies specific for HIV-1 Env gp41. Antibodies from AHI patients show a decreased CDR3H length and an increased mutation frequency when compared to influenza vaccinated individuals. The high mutation frequency is coupled with a comparatively low synonymous to non-synonymous mutation ratio in the heavy chain. Our results may suggest presence of positive antigenic selection in previously triggered non-HIV-1 memory B cells in AHI.

Taken together, the studies presented in this thesis provide methods to study diversification in pathogens, and invertebrate and vertebrate immune systems.


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Books on the topic "Immune diversification"

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Kelsoe, Garnett, and Martin F. Flajnik, eds. Somatic Diversification of Immune Responses. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-71984-4.

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Kelsoe, Garnett, and Martin Flajnik. Somatic Diversification of Immune Responses. Springer London, Limited, 2012.

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Kelsoe, Garnett, and Martin Flajnik. Somatic Diversification of Immune Responses. Springer London, Limited, 2011.

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Determinant spreading and diversification of immune response. Copenhagen: Munksgaard, 1998.

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Evolution of the Immune System: Conservation and Diversification. Elsevier Science & Technology Books, 2016.

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Malagoli, Davide. Evolution of the Immune System: Conservation and Diversification. Elsevier Science & Technology Books, 2016.

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Somatic Diversification of Immune Responses (Current Topics in Microbiology and Immunology). Springer-Verlag Telos, 1998.

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West-Eberhard, Mary Jane. Developmental Plasticity and Evolution. Oxford University Press, 2003. http://dx.doi.org/10.1093/oso/9780195122343.001.0001.

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The first comprehensive synthesis on development and evolution: it applies to all aspects of development, at all levels of organization and in all organisms, taking advantage of modern findings on behavior, genetics, endocrinology, molecular biology, evolutionary theory and phylogenetics to show the connections between developmental mechanisms and evolutionary change. This book solves key problems that have impeded a definitive synthesis in the past. It uses new concepts and specific examples to show how to relate environmentally sensitive development to the genetic theory of adaptive evolution and to explain major patterns of change. In this book development includes not only embryology and the ontogeny of morphology, sometimes portrayed inadequately as governed by "regulatory genes," but also behavioral development and physiological adaptation, where plasticity is mediated by genetically complex mechanisms like hormones and learning. The book shows how the universal qualities of phenotypes--modular organization and plasticity--facilitate both integration and change. Here you will learn why it is wrong to describe organisms as genetically programmed; why environmental induction is likely to be more important in evolution than random mutation; and why it is crucial to consider both selection and developmental mechanism in explanations of adaptive evolution. This book satisfies the need for a truly general book on development, plasticity and evolution that applies to living organisms in all of their life stages and environments. Using an immense compendium of examples on many kinds of organisms, from viruses and bacteria to higher plants and animals, it shows how the phenotype is reorganized during evolution to produce novelties, and how alternative phenotypes occupy a pivotal role as a phase of evolution that fosters diversification and speeds change. The arguments of this book call for a new view of the major themes of evolutionary biology, as shown in chapters on gradualism, homology, environmental induction, speciation, radiation, macroevolution, punctuation, and the maintenance of sex. No other treatment of development and evolution since Darwin's offers such a comprehensive and critical discussion of the relevant issues. Developmental Plasticity and Evolution is designed for biologists interested in the development and evolution of behavior, life-history patterns, ecology, physiology, morphology and speciation. It will also appeal to evolutionary paleontologists, anthropologists, psychologists, and teachers of general biology.
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Dahiya, Surbhi. Indian Media Giants. Oxford University PressDelhi, 2021. http://dx.doi.org/10.1093/oso/9780190132620.001.0001.

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Abstract The establishment of mass media organizations in India is contemporaneous with that of its counterparts in the developed world. Indian Media Giants: Unveiling the Business Dynamics of Print Legacies is an analytical chronicle of six Indian mega media conglomerates' individual odyssey from their humble, incipient beginnings in the pre-independence era to their transformation into powerful business empires in the digitised world. The book traces Indian Media metamorphosis, the birth, phase-wise contours of growth and development, travails and trajectories, organizational structures, editorial policies and business dynamics of print majors in India, namely, The Times Group, The Hindu Group, The Hindustan Times Limited, The Indian Express Group, Dainik Jagran Limited and DB Corp Limited. It unravels their understanding of the values of co-dependence, collaboration, and competition with their contemporaries. It is an untold story of how these organizations leapt over the perimeters of conventional greatness to achieve unmeasured success that spans the globe. The book analyses how innovations have been brought in the management policies of these print businesses, with respect to production, distribution, consumption, while accrediting the visionary leadership that drives each organisation forward in its endeavours. What the case studies also details, is the wide extent of strategic intent enunciation; the role of product lines, development and diversification into radio, TV, digital and other segments; geographical spread, expansion, regional penetration and international footprint; the role of technological advancements in throwing up unimaginably new business opportunities; strategic alliances, mergers, acquisitions, joint ventures and takeovers; manpower management policies; CSR activities and financial performance of these media giants. The theoretical implications of the growth of media organisations in terms of the nature of mass media and its products are also underlined. The book focuses on the theoretical framework of media management and pays attention on the changing media management practices from one era to another, gradually orienting and re-orienting the strategic positioning of respective media giants to the pulse of the media market and the opportunities under various regulatory regimes. It is replete with the meticulous analysis of the editorial values and business dynamics upon which their legacies are founded, changing business models adopted by the media moguls, the ripples they have created in the media world and how they are constantly being modified to suit the tastes of the modernising market. With this, and more, Indian Media Giants is a holistic compendium that offers multiple perspectives on how print media organizations in India have grown from strength to strength and have become platform agnostic. The book also details the changing media landscape in India and also underlines the efforts of media giants in retaining print while embracing the digital. The book will be of immense value to the academic fraternity and industry professionals to gain an incisive as well as panoptic view and understanding of the Indian media conglomerates. Compressed in these pages is the analytical story of the past, present and future of the Indian print legacies for the pleasure and curiosity of the readers.
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Book chapters on the topic "Immune diversification"

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Michaeli, Miri, and Ramit Mehr. "Antigen receptor diversification during immune responses." In Systems Immunology, 199–212. CRC Press, 2018. http://dx.doi.org/10.1201/9781315119847-12.

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Litman, Gary W., John P. Cannon, and Jonathan P. Rast. "New Insights into Alternative Mechanisms of Immune Receptor Diversification." In Advances in Immunology, 209–36. Elsevier, 2005. http://dx.doi.org/10.1016/s0065-2776(05)87006-3.

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Schmid-Hempel, Paul. "The natural history of defences." In Evolutionary Parasitology, 51–108. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780198832140.003.0004.

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Hosts can avoid infections by behavioural changes and by body walls. After infection, hosts can change their behaviours to reduce the effects of parasitism. Immune defences have different arms (humoral or cellular), and organization (innate, adaptive). Innate immunity consists of a collection of different systems that are evolutionarily very old. Adaptive immunity, based on expansion of specific lymphocytes, evolved in the higher vertebrates. Immune defences are regulated tightly and based on receptors that can recognize parasites (or their activity). This triggers a complex signalling cascade that results in the production of further signalling compounds and effectors. Important protein families, e.g. the immunoglobulins, form the molecular backbone. A key to efficient defences is the diversification of receptors, such as the highly evolved somatic diversification processes of advanced adaptive immunity. The microbiota adds to defences in many ways. Immune memory and priming occur throughout the tree of life.
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Oren, Matan, Megan A. Barela Hudgell, Preethi Golconda, Cheng Man Lun, and L. Courtney Smith. "Genomic Instability and Shared Mechanisms for Gene Diversification in Two Distant Immune Gene Families: The Plant NBS-LRR Genes and the Echinoid 185/333 Genes." In The Evolution of the Immune System, 295–310. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-801975-7.00012-8.

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Marwaha, Lovleen. "Quality Influencing Factors and Disease Resistance in Queen of Apis mellifera (Hymenoptera: Apidae)." In The Polyandrous Queen Honey Bee: Biology and Apiculture, 83–110. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815079128112010006.

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Before the 4th instar larval phase, worker larvae exhibit totipotency to develop into either female caste. In subsequent larval stages, differential expression of various genetic elements occurs under the prominent induction of royal jelly, developmental hormones, and volatile queen emission. In the honey bee female caste, anatomical reproductive disproportionality establishes due to this diversification of genomic expression. Exponential fertility and pheromonal profiling of the queen regulate colonial strength, colonial productivity, submissive behaviour, and the development of workers. Different factors prevailing within the hive or outside of the colony premises influence the queen's quality. For example, the queen's fecundity is negatively proportional to the age of the worker larva before entering the queen differentiation pathway. Further, numerous additional factors like genomic content, physiology, quality and quantity of royal jelly, colonial food storage, social environment, queen pheromones, etc. influence queen reproductive potential. Further, queens have differential immune protective characteristics for different pathogens and parasites. This chapter highlights influencing factors for non-synchronous ovarian development and variant immune-protective measures in female honey bees. The subsequent chapters elucidate the details of workers' ovarian programmed cell death under the regulation of multiple factors.
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Norris, Emily T., Lavanya Rishishwar, and I. King Jordan. "Rapid, Adaptive Human Evolution Facilitated by Admixture in the Americas." In Human Migration, 122–38. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190945961.003.0011.

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Humans have migrated from their ancestral homelands in Africa to nearly every part of the world. Human migration is characterized by a recurrent process of physical isolation and genetic diversification followed by admixture, whereby previously isolated populations come together and exchange genes. Admixture results in the introgression of alleles from ancestral source populations into hybrid admixed populations, and introgression can facilitate rapid, adaptive evolution by introducing beneficial alleles at intermediate frequencies. We provide examples of adaptive introgression between archaic and modern human populations and for admixed populations in the Americas, which were formed relatively recently via admixture among African, European, and Indigenous American ancestral populations. Adaptive introgression has had an outsized effect on the human immune system. In light of the ubiquity of admixture in human evolution, we propose that adaptive introgression is a fundamentally important mechanism for driving rapid, adaptive evolution in human populations.
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Iraki, Frederick Kang'ethe. "Opportunities and Challenges of Mobile Technologies in Higher Education Pedagogy in Africa." In Advancing Higher Education with Mobile Learning Technologies, 170–78. IGI Global, 2015. http://dx.doi.org/10.4018/978-1-4666-6284-1.ch009.

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Since the late 1990s, Kenya has undergone a real technological revolution, especially in the domain of mobile telephony and Internet connectivity. From a negligible number of handsets in the hands of the political elites, today almost every adult Kenyan has a mobile phone, or access to one. This is thanks to reduced costs following expansion and diversification of the market niche. Despite this remarkable progress, research has shown that cell phones are used mainly for financial transactions, social communication, and entertainment, but hardly for learning purposes. This means that despite the impressive number of smartphone owners in the university, for example, the devices are not used for enhancing student learning or teaching. In Kenya, more than 60% of the population employs mobile banking, thus underscoring the immense potential that the cell phones have for education. This chapter explores the benefits and challenges in employing mobile telephony to improve the quality of teaching and learning.
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Conference papers on the topic "Immune diversification"

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Yoshikawa, Masaya, Akira Naruse, and Shinsuke Souboku. "Adaptive immune algorithm considering intensification and diversification." In Integration (IRI). IEEE, 2009. http://dx.doi.org/10.1109/iri.2009.5211590.

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Oh, David Y., Jason Cham, Li Zhang, Grant Fong, Mark Klinger, Malek Faham, and Lawrence Fong. "Abstract 4362: T cell repertoire diversification is associated with immune related toxicities following immune checkpoint inhibition in metastatic cancer patients." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4362.

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