Academic literature on the topic 'Immune diversification'
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Journal articles on the topic "Immune diversification"
Sercarz, Eli E. "Immune focusing vs diversification and their connection to immune regulation." Immunological Reviews 164, no. 1 (August 1998): 5–10. http://dx.doi.org/10.1111/j.1600-065x.1998.tb01202.x.
Full textRadic, Marko Z., and Moncef Zouali. "Receptor Editing, Immune Diversification, and Self-Tolerance." Immunity 5, no. 6 (December 1996): 505–11. http://dx.doi.org/10.1016/s1074-7613(00)80266-6.
Full textde Villartay, Jean-Pierre, Alain Fischer, and Anne Durandy. "The mechanisms of immune diversification and their disorders." Nature Reviews Immunology 3, no. 12 (December 2003): 962–72. http://dx.doi.org/10.1038/nri1247.
Full textBorkowsky, William, Elizabeth J. McFarland, Ram Yogev, Yonghua Li, and Paul Harding. "Correlation of HIV-Specific Immunity, Viral Control, and Diversification following Planned Multiple Exposures to Autologous HIV in a Pediatric Population." Clinical and Vaccine Immunology 18, no. 10 (August 3, 2011): 1628–31. http://dx.doi.org/10.1128/cvi.05176-11.
Full textMilstein, C. "From antibody structure to immunological diversification of immune response." Science 231, no. 4743 (March 14, 1986): 1261–68. http://dx.doi.org/10.1126/science.3080810.
Full textMamula, Mark J., and Charles A. Janeway. "Do B cells drive the diversification of immune responses?" Immunology Today 14, no. 4 (April 1993): 151–52. http://dx.doi.org/10.1016/0167-5699(93)90274-o.
Full textHughes, Austin L. "Natural selection and the diversification of vertebrate immune effectors." Immunological Reviews 190, no. 1 (December 2002): 161–68. http://dx.doi.org/10.1034/j.1600-065x.2002.19012.x.
Full textVeillette, André. "Introduction: Signaling and signal diversification in antigen‐specific immune cells." Immunological Reviews 291, no. 1 (August 12, 2019): 5–7. http://dx.doi.org/10.1111/imr.12795.
Full textPasquier, Louis Du. "Germline and somatic diversification of immune recognition elements in Metazoa." Immunology Letters 104, no. 1-2 (April 2006): 2–17. http://dx.doi.org/10.1016/j.imlet.2005.11.022.
Full textWang, C., M. A. Bogue, D. B. Roth, and K. Meek. "Normal junctional diversification of immune receptors in p53-deficient mice." Journal of Immunology 159, no. 2 (July 15, 1997): 757–62. http://dx.doi.org/10.4049/jimmunol.159.2.757.
Full textDissertations / Theses on the topic "Immune diversification"
Marin, Frédéric. "Diversification du répertoire génomique immun chez le mouton : analyse moléculaire du segment Vl et étude de sa possible implication sur le mécanisme de diversification somatique du répertoire B, première exploration du "locus" H et du processus dediversificatiom qui y opère." Paris 5, 1993. http://www.theses.fr/1993PA05P230.
Full textMunshaw, Supriya Shaunak. "Computational Methods to Study Diversification in Pathogens, and Invertebrate and Vertebrate Immune Systems." Diss., 2010. http://hdl.handle.net/10161/2429.
Full textPathogens and host immune systems use strikingly similar methods of diversification. Mechanisms such as point mutations and recombination help pathogens escape the host immune system and similar mechanisms help the host immune system attack rapidly evolving pathogens. Understanding the interplay between pathogen and immune system evolution is crucial to effective drug and vaccine development. In this thesis we employ various computational methods to study diversification in a pathogen, an invertebrate and a vertebrate immune system.
First, we develop a technique for phylogenetic inference in the presence of recombination based on the principle of minimum description length, which assigns a cost-the description length-to each network topology given the observed sequence data. We show that the method performs well on simulated data and demonstrate its application on HIV
Next, we demonstrate via phylogenetic analysis that the evolution of repeats in an immune-related gene family in
Third, we develop a probabilistic model of the immunoglobulin (Ig) rearrangement process and a Bayesian method for estimating posterior probabilities for the comparison of multiple plausible rearrangements. We validate the software using various datasets and in all tests, SoDA2 performed better than other available software.
Finally, we characterize the somatic population genetics of the nucleotide sequences of >1000 recombinant Ig pairs derived from the blood of 5 acute HIV-1 infected (AHI) subjects. We found that the Ig genes from the 20 day AHI PC showed extraordinary clonal relatedness among themselves; a single clone comprised of 52 members, with observed and inferred precursor antibodies specific for HIV-1 Env gp41. Antibodies from AHI patients show a decreased CDR3H length and an increased mutation frequency when compared to influenza vaccinated individuals. The high mutation frequency is coupled with a comparatively low synonymous to non-synonymous mutation ratio in the heavy chain. Our results may suggest presence of positive antigenic selection in previously triggered non-HIV-1 memory B cells in AHI.
Taken together, the studies presented in this thesis provide methods to study diversification in pathogens, and invertebrate and vertebrate immune systems.
Dissertation
Books on the topic "Immune diversification"
Kelsoe, Garnett, and Martin F. Flajnik, eds. Somatic Diversification of Immune Responses. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-71984-4.
Full textKelsoe, Garnett, and Martin Flajnik. Somatic Diversification of Immune Responses. Springer London, Limited, 2012.
Find full textKelsoe, Garnett, and Martin Flajnik. Somatic Diversification of Immune Responses. Springer London, Limited, 2011.
Find full textDeterminant spreading and diversification of immune response. Copenhagen: Munksgaard, 1998.
Find full textEvolution of the Immune System: Conservation and Diversification. Elsevier Science & Technology Books, 2016.
Find full textMalagoli, Davide. Evolution of the Immune System: Conservation and Diversification. Elsevier Science & Technology Books, 2016.
Find full textSomatic Diversification of Immune Responses (Current Topics in Microbiology and Immunology). Springer-Verlag Telos, 1998.
Find full textWest-Eberhard, Mary Jane. Developmental Plasticity and Evolution. Oxford University Press, 2003. http://dx.doi.org/10.1093/oso/9780195122343.001.0001.
Full textDahiya, Surbhi. Indian Media Giants. Oxford University PressDelhi, 2021. http://dx.doi.org/10.1093/oso/9780190132620.001.0001.
Full textBook chapters on the topic "Immune diversification"
Michaeli, Miri, and Ramit Mehr. "Antigen receptor diversification during immune responses." In Systems Immunology, 199–212. CRC Press, 2018. http://dx.doi.org/10.1201/9781315119847-12.
Full textLitman, Gary W., John P. Cannon, and Jonathan P. Rast. "New Insights into Alternative Mechanisms of Immune Receptor Diversification." In Advances in Immunology, 209–36. Elsevier, 2005. http://dx.doi.org/10.1016/s0065-2776(05)87006-3.
Full textSchmid-Hempel, Paul. "The natural history of defences." In Evolutionary Parasitology, 51–108. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780198832140.003.0004.
Full textOren, Matan, Megan A. Barela Hudgell, Preethi Golconda, Cheng Man Lun, and L. Courtney Smith. "Genomic Instability and Shared Mechanisms for Gene Diversification in Two Distant Immune Gene Families: The Plant NBS-LRR Genes and the Echinoid 185/333 Genes." In The Evolution of the Immune System, 295–310. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-801975-7.00012-8.
Full textMarwaha, Lovleen. "Quality Influencing Factors and Disease Resistance in Queen of Apis mellifera (Hymenoptera: Apidae)." In The Polyandrous Queen Honey Bee: Biology and Apiculture, 83–110. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815079128112010006.
Full textNorris, Emily T., Lavanya Rishishwar, and I. King Jordan. "Rapid, Adaptive Human Evolution Facilitated by Admixture in the Americas." In Human Migration, 122–38. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190945961.003.0011.
Full textIraki, Frederick Kang'ethe. "Opportunities and Challenges of Mobile Technologies in Higher Education Pedagogy in Africa." In Advancing Higher Education with Mobile Learning Technologies, 170–78. IGI Global, 2015. http://dx.doi.org/10.4018/978-1-4666-6284-1.ch009.
Full textConference papers on the topic "Immune diversification"
Yoshikawa, Masaya, Akira Naruse, and Shinsuke Souboku. "Adaptive immune algorithm considering intensification and diversification." In Integration (IRI). IEEE, 2009. http://dx.doi.org/10.1109/iri.2009.5211590.
Full textOh, David Y., Jason Cham, Li Zhang, Grant Fong, Mark Klinger, Malek Faham, and Lawrence Fong. "Abstract 4362: T cell repertoire diversification is associated with immune related toxicities following immune checkpoint inhibition in metastatic cancer patients." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4362.
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