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Dissertations / Theses on the topic 'Immortalisation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Seow, Choon Sheong. "Analysis of gene expression in tumour immortalisation." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251848.

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Cellular senescence is an irreversible growth-arrested state seen in primary human cells after a finite number of cell divisions both in culture and <i>in vivo</i>. The escape from senescence to immortalisation is often thought to be a prerequisite for carcinogenesis. Many changes in senescent cells are consistent with changes in tissue and organ function with age. I used serial analysis of gene expression (SAGE) to analyse global gene expression profiles in senescent and early passage human foetal fibroblasts (hff). A total of over 20,000 SAGE tags were sequenced and characterised, correspond

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2

Wen, Victoria Wei-Yu Women's &amp Children's Health Faculty of Medicine UNSW. "Molecular alterations during immortalisation of human endothelial cells." Awarded by:University of New South Wales. Women's & Children's Health, 2009. http://handle.unsw.edu.au/1959.4/44743.

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Replicative exhaustion of endothelial cells (ECs) contributes to the pathogenesis of age-related vascular disorders, including atherosclerosis and impaired wound healing. Conversely, abnormal proliferation of ECs underlies the development of EC-derived malignancies, such as haemangioblastoma and angiosarcoma. The central objective of this thesis was to delineate mechanisms that regulate the replicative lifespan of human ECs and molecular alterations that occur during immortalisation of ECs. The gradual shortening of telomeres (chromosome-end structures) is one mechanism that restricts the repl

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3

Grix, Nicola. "Conditional immortalisation of mouse auditory sensory epithelial cells." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414134.

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4

Linne, Hannah Louise. "Investigating telomerase regulation in human breast cancer cells : a search for telomerase repressor sequences localised to chromosome 3P." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11620.

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Cellular immortality is one of the ten hallmarks of human cancer and has been shown to be an essential prerequisite for malignant progression (Hanahan and Weinberg., 2011, Newbold et al., 1982, Newbold and Overell., 1983). In contrast, normal human somatic cells proliferate for a limited number of population doublings before entering permanent growth arrest known as replicative senescence. This is thought to be due to the progressive shortening of telomeric sequences with each round of cell division. Over 90% of human tumours, but not the majority of human somatic cells, have been found to exp

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5

Kan, Chin-Yi. "Human Papillomavirus in human breast cancer and cellular immortalisation." Sydney : University of New South Wales. Biotechnology and Biomolecular Sciences, 2007. http://www.library.unsw.edu.au/~thesis/adt-NUN/public/adt-NUN20071004.080541/.

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6

McDonald, Jacqueline. "Conditional immortalisation of myeloid-precursors to model innate immunity." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/45729/.

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The prevalence of fungal infections is on the rise due to the increase of immune suppressed individuals. Neutrophils are key immune cells in the fight against fungal infections. The study of neutrophil biology is hampered by the short lived nature of the cells and the fact that they cannot be easily genetically modified. In this thesis, I generate and characterise myeloid precursor cell lines that can be genetically manipulated and differentiated into functional neutrophils. These in vitro generated neutrophils were adoptively transferred into live animals and tracked during inflammatory respo

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7

Flanagan, James Michael. "The immortalisation of B-lymphocytes with Epstein-Barr virus /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16501.pdf.

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8

Kohli, Jaskaren Singh. "Senescence and immortalisation in melanoma progression and multiple primary melanoma." Thesis, St George's, University of London, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706529.

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Multiple primary melanoma is defined as the gain of at least one additional independent melanoma and occurs in approximately 5% of melanoma patients. Germline mutations can be identified in genes in these patients, which are known to, or are predicted to result in an extension of melanocyte lifespan e.g. pl6, CDK4, and components of the telomere shelterin cap. We therefore hypothesised that 'normal' melanocytes from pl6 and CDK4 wild-type multiple primary melanoma patients have a statistically longer lifespan compared to those from single primary melanoma patients. Melanocytes from multiple pr

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9

Zwermann, Birgit. "Die Rolle der Telomerase in der Immortalisation und malignen Transformation von Nebennierenrindenzellen." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-145498.

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10

Whitaker, Noel James. "Involvement of p53 and RB-1 in the immortalisation of human cells." Thesis, The University of Sydney, 1995. https://hdl.handle.net/2123/27505.

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Normal diploid mammalian cells undergo a finite number of population doublings in culture before they undergo senescence [Hayflick & Moorhead, 1961]. In contrast, tumours often contain "immortalised" cells that exhibit an apparently unlimited in vitro and in vivo proliferative potential. Fusion of normal and immortalised cells usually results in hybrids with limited proliferative potential [Bunn & Tarrant, 1980; Muggleton-Harris & DeSimone, 1980] indicating that immortalisation is probably due to loss of normal gene function. Similarly, fusion of different immortalised human cell lines with ea

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11

Keough, Rebecca Anne. "An investigation of hair follicle cell immortalisation and hair keratin gene regulation /." Title page, table of contents and summary only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phk373.pdf.

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12

Parouchev, Alexandre. "Immortalisation et transplantation de cellules hépatiques simiennes : modèles de thérapie cellulaire hépatique." Paris 7, 2010. http://www.theses.fr/2010PA077099.

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La transplantation orthotopique de foie est le seul traitement curatif de certains déficits métaboliques. Mais, le manque de donneurs et les complications liées à l’ immunosuppression incitent au développement d'alternatives thérapeutiques, dont la transplantation d'hépatocytes. Cependant, à ce jour les essais avec hépatocytes adultes sont peu fructueux. Nous avons exploré deux voies thérapeutiques. D'une part dans la recherche de sources alternatives de cellules, nous avons caractérisé une lignée de cellules hépatiques fœtales simiennes (IPFLS), immortalisées par l'antigène T de SV40, à long

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13

Muntoni, Alessandra. "Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation." Thesis, University of Glasgow, 2002. http://theses.gla.ac.uk/1710/.

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Oral cancer has caused great concern in all of the western countries over the past two decades because of its progressively increasing incidence, mainly in young males, and its consistently low 5-year survival rate. Oral premalignant lesions (dysplasias) are thought to precede the development of cancer, but no clinical or histological criteria is at present available to predict their potential for malignant transformation. Therefore, it would be of diagnostic and therapeutic relevance to understand the molecular event, involved at different stages of oral cancer. Using a unique series of prima

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14

Berrington, Mary. "Investigation of the role of chromosome 7 in human cell immortalisation and cancer." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301836.

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15

Tzellos, Stelios. "Mechanism of superior B cell immortalisation activity of type 1 Epstein-Barr virus." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/23223.

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Epstein-Barr virus (EBV) establishes lifelong latent infections in humans. EBV isolates worldwide are classified as type 1 or type 2 based on their EBNA-2 gene sequence. Type 1 EBV is more efficient at B cell transformation, a property previously mapped to the EBNA-2 locus. Previous work using EREB2.5 cells in a trans-complementation assay showed that the superior ability of type 1 EBNA-2 to sustain B cell proliferation is mostly determined by its C-terminal region. In this study, conversion of a single amino acid in the transactivation domain (TAD), from serine in type 2 EBNA-2 to the asparta

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16

Boolay, Sihaam. "Immortalisation, characterisation and differentiation of temperature sensitive cell lines from the Olfactory Neuroepithelium." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/22552.

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Bibliography: p. 194-210.<br>Embryonic olfactory neuroepithelium provides a useful experimental system for the study of olfactory neurogenesis. As a substrate for experimental neural cell biology, olfactory neuroepithelium is of unique interest since, unlike other neural cells, olfactory neurons are continually replaced - a feature that is dictated by their direct exposure to the damaging external environment. Basal cells in the olfactory placode are the source of this replacement. Each olfactory neuron expresses only one or a few of the many olfactory receptors that are encoded by the large a

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17

Bayad, Jamal. "Immortalisation de lignées cellulaires hépatocytaires : expression et régulation des enzymes du métabolisme des xenobiotiques." Nancy 1, 1991. http://www.theses.fr/1991NAN10450.

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18

Aure, Karine. "Physiopathologie moléculaire et cellulaire des maladies mitochondriales à présentation neurologique." Paris 6, 2007. http://www.theses.fr/2007PA066281.

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Les maladies mitochondriales sont liées à un déficit de la chaîne respiratoire mitochondriale. Ces maladies posent des problèmes de diagnostic, dans leurs relations phénotype/génotype et dans leurs mécanismes physiopathologiques. L'étude longitudinale d'un cas de déficit en ubiquinone a démontré les limites de la supplémentation thérapeutique. L'analyse de l’histoire naturelle et des caractéristiques moléculaires de 69 patients porteurs de délétion de l’ADN mitochondrial a permis d'établir une nouvelle classification clinique et des facteurs pronostiques. L’efficacité de l’immortalisation par

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19

Powell, Andrew Jonathan. "Studies on the immortalisation of rodent embryo fibroblasts by simian virus 40 large tumour antigen." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307774.

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20

Bernard, Rozenn. "Transfert de gènes dans des précurseurs gliaux : immortalisation cellulaire, prolifération et différenciation des lignées établies." Paris 11, 1994. http://www.theses.fr/1994PA11T009.

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21

Allain, Jean-Etienne. "Immortalisation et transplantation de cellules foetales hépatiques simiennes et humaines : modèles de thérapie cellulaire hépatique." Paris 7, 2002. http://www.theses.fr/2002PA077004.

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22

Perrem, Kilian Thomas. "Molecular Studies of an alternative lengthening of telomeres (ALT) mechanism." Thesis, The University of Sydney, 2001. http://hdl.handle.net/2123/793.

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Telomeres are specialised structures, consisting of TTAGGG DNA repeats and binding proteins, that cap the ends of human chromosomes and maintain chromosome integrity. It has been shown that telomeres shorten with each round of cell division in most normal human somatic cells. It has become generally accepted that this shortening is due, in part, to the inability of DNA polymerases to replicate the extreme ends of chromosomes which is a phenomenon known as the 'end replication problem'. An intriguing hypothesis that has emerged from these observations is that critically shortened telomere

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23

Perrem, Kilian Thomas. "Molecular Studies of an alternative lengthening of telomeres (ALT) mechanism." University of Sydney. Children's Medical Research Institute, 2001. http://hdl.handle.net/2123/793.

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Telomeres are specialised structures, consisting of TTAGGG DNA repeats and binding proteins, that cap the ends of human chromosomes and maintain chromosome integrity. It has been shown that telomeres shorten with each round of cell division in most normal human somatic cells. It has become generally accepted that this shortening is due, in part, to the inability of DNA polymerases to replicate the extreme ends of chromosomes which is a phenomenon known as the �end replication problem�. An intriguing hypothesis that has emerged from these observations is that critically shortened telomere

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24

Horton, Sarah Jayne. "Establishment of an in vitro model to identify the molecular mechanism of immortalisation by MLL-ENL." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444423/.

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The t (l I 19)(p22 q23) translocation, which gives rise to the MLL-ENL fusion protein is commonly found in infant acute leukaemias of both the myeloid and lymphoid lineage. In order to study the molecular mechanism of haematopoietic progenitor cell (HPC) immortalisation by MLL-ENL, a conditional system of MLL- ENL expression was established in primary murine HPCs. This was achieved by delivering the Tet-Off inducible expression system to primary cells using two retroviral expression constructs. Several conditional immortalised myeloid cell lines were generated in vitro which were dependent on

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25

BERTHON, PHILIPPE. "Immortalisation et transformation tumorale de l'epithelium mammaire humain normal : caracterisation et reponse aux facteurs de croissance." Paris 6, 1992. http://www.theses.fr/1992PA066043.

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En utilisant un vecteur plasmidique recombine avec le grand t de sv40 (t-sv40) nous avons immortalise des cellules epitheliales mammaires humaines normales (cemh) etablies en culture primaire a long terme. La transfection genomique et fonctionnelle des cemh par t-sv40 a permis l'etablissement des lignees immortalisees s2t2, s1t3 et s3t3. La lignee s2t2 est a l'origine de plusieurs clones ns2t2 de cellules transformees. Les cemh proliferent pendant 32 generations avec un temps de doublement de 446 heures. Etudiee pendant 2 ans, la proliferation des lignees mammaires immortalisees et transformee

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26

Pickles, Jessica Chiara. "Mechanisms of senescience bypass in cells derived from the Syrian hamster embryo cell transformation assay." Thesis, Brunel University, 2014. http://bura.brunel.ac.uk/handle/2438/10526.

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Recent European legislation has enforced a reduction in the use of animal models for safety assessment purposes and carcinogenicity testing. The Syrian hamster embryo cell transformation assay (SHE CTA) has been proposed as a suitable animal alternative, but its implementation into test batteries has been delayed. This is due to concerns regarding the assay’s endpoint subjectivity and, moreover, the model’s relevance to carcinogenicity remains mostly unexplored. Senescence is an essential barrier against uncontrolled cell proliferation and its evasion is necessary for clonal evolution and tumo

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27

Zwermann, Birgit Verfasser], and Felix [Akademischer Betreuer] [Beuschlein. "Die Rolle der Telomerase in der Immortalisation und malignen Transformation von Nebennierenrindenzellen / Birgit Zwermann. Betreuer: Felix Beuschlein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1024483878/34.

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28

Löfqvist, Madelaine. "The role of Epstein-Barr virus nuclear antigen 3C in the immortalisation process of primary human B-lymphocytes." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-23230.

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29

Bikkul, Mehmet Ural. "Using drug treatments to control genome behaviour in normal and Hutchinson-Gilford Progeria Syndrome fibroblasts, with and without hTERT immortalisation." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/12774.

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Hutchinson-Gilford Progeria Syndrome (HGPS) is an exceedingly rare genetic condition with striking features reminiscent of marked premature ageing. HGPS is commonly caused by a ‘classic’ mutation in the A-type lamin gene, LMNA (G608G). This leads to the expression of an aberrant truncated lamin A protein, progerin. The nuclear lamina is known to anchor chromosomes, stabilising and regulating the genome. Interphase chromosomes are non-randomly positioned in the nuclei of cells and they occupy specific locations with respect to a radial distribution, gene-poor chromosomes are positioned at the n

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30

Pon, Robert A. "The generation, immortalisation, and characterisation of human gammadelta T cells derived from the blood and cerebrospinal fluid of MS patients." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9045.

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Multiple sclerosis (MS) is believed to be an autoimmune, inflammatory, demyelinating disease of the central nervous system (CNS), resulting in myelin degradation, loss of the myelin forming cell, the oligodendrocyte (ODC), and axonal degeneration. The hypothesis underlying this work is that gammadelta T cells play a distinct role in MS pathogenesis by initiating, perpetuating, or regulating the immune response directed against the myelin/ODC unit. Initial comparative experiments utilising short term gammadelta T cell lines from peripheral blood (PB) and cerebrospinal fluid (CSF) of MS and othe

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31

Thenet, Sophie. "Immortalisation de chondrocytes articulaires de lapin par les fonctions precoces du virus sv40. Etude de la modulation des fonctions differenciees." Paris 7, 1992. http://www.theses.fr/1992PA077196.

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Nous avons etabli des lignees de chondrocytes articulaires de lapin en utilisant le pouvoir immortalisant de certains oncogenes, puis, nous avons etudie la possibilite chez les chondrocytes immortalises d'exprimer ou de reexprimer les fonctions specifiques du cartilage. La transfection de chondrocytes articulaires de lapin en primoculture par un plasmide portant les fonctions precoces de sv40 nous a permis d'isoler plusieurs clones de chondrocytes immortalises. Ces cellules s'expriment l'antigene grand t de sv40, presentent un caryotype hypotetraploide et une tumorigenicite faible chez la sour

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32

DJELLOUL, SIHAM. "Immortalisation des cellules epitheliales digestives par l'oncogene grand t de sv40 : consequences sur la transformation, la differenciation et l'effet antiproliferatif du tgf1." Paris 6, 1997. http://www.theses.fr/1997PA066066.

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Nous demontrons ici que l'immortalisation de cellules epitheliales isolees de l'estomac ou de l'intestin chez le rat (modeles rgc et eski), apres infection par des retrovirus recombinants pour le sv40lt, est associee a l'emergence de cellules epitheliales 1) relativement indifferenciees et possedant certains determinants specifiques de l'epithelium digestif 2) capables de resister aux effets antiproliferatifs du tgf. Cependant, la differenciation enterocytaire est compatible avec le transfert de sv40lt et la perte de l'anti-oncogene p53 dans les cellules coliques humaines caco-2, suggerant ain

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33

BORDE, ISABELLE. "Transfert de genes et immortalisation de precurseurs de cellules nerveuses murines. Etude de la proliferation et de la differenciation des lignees immortalisees." Paris 7, 1994. http://www.theses.fr/1994PA077012.

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Nous avons transferre de facon stable, dans des cellules nerveuses murines, des genes immortalisants: les oncogenes grand t de polyome et grand t de sv40. Nous avons ainsi obtenu des lignees cellulaires variees issues de differentes regions du cerveau (cortex, mesencephale et striatum) qui correspondent a differents types de precurseurs de cellules nerveuses. D'autres lignees ont ete etabli a partir de souris transgeniques portant le gene grand t du virus polyome. Certaines de ces lignees sont des precurseurs astrogliaux qui montrent une correlation entre le controle de la division cellulaire

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34

Thorley, Matthew. "Analysis of the dystrophin interactome." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066619.pdf.

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Le but de ce projet était d'identifier de manière méthodique et standardisée les partenaires interagissant avec la protéine dystrophine dans les cellules musculaires squelettiques humaines différenciées et découvrir de nouveaux rôles de la dystrophine. Des cellules immortalisées ont été obtenue en sur-exprimant de manière stable hTERT / CDK4. Nous avons réalisé une analyse transcriptomique comparant des lignées immortalisées avec leurs populations primaires correspondantes, à l’état de prolifération et de différentiation. Nous avons constaté que l'immortalisation n'a pas d'effet mesurable sur

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35

Thorley, Matthew. "Analysis of the dystrophin interactome." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066619/document.

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Le but de ce projet était d'identifier de manière méthodique et standardisée les partenaires interagissant avec la protéine dystrophine dans les cellules musculaires squelettiques humaines différenciées et découvrir de nouveaux rôles de la dystrophine. Des cellules immortalisées ont été obtenue en sur-exprimant de manière stable hTERT / CDK4. Nous avons réalisé une analyse transcriptomique comparant des lignées immortalisées avec leurs populations primaires correspondantes, à l’état de prolifération et de différentiation. Nous avons constaté que l'immortalisation n'a pas d'effet mesurable sur

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36

Ait, Mebarek Mazhoura. "Nouvelles approches méthodologiques pour l'obtention d'anticorps humains monoclonaux." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00829106.

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Les anticorps monoclonaux représentent aujourd'hui un outil de choix en thérapeutique et en diagnostic. Les anticorps thérapeutiques sont des biomédicaments en plein essor depuis les années 1970 et représentent 10% du marché des produits pharmaceutiques. Les anticorps monoclonaux sont utilisés dans divers domaines : en cancérologie, pour lutter contre les maladies auto-immunes ou en infectiologie. Le nombre des anticorps monoclonaux en développement ne cesse d'augmenter. Les premiers anticorps monoclonaux utilisés en thérapie étaient d'origine murine et leur administration à l'Homme est suscep

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37

STEIMBERG, NATHALIE. "Immortalisation de chondrocytes articulaires de lapin par l'antigene grand t de sv40 place sous le controle des sequences regulatrices du gene du collagene de type ii." Paris 7, 1997. http://www.theses.fr/1997PA077297.

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Le chondrocyte, unique type cellulaire du cartilage, est responsable de la synthese de la matrice cartilagineuse, essentiellement composee de collagene de type ii et d'agregats d'agrecanne. Au cours de la culture, l'expression de ces fonctions differenciees est rapidement perdue. Plusieurs equipes se sont donc interessees a l'immortalisation de chondrocytes afin d'etablir des lignees immortalisees et differenciees. L'expression du phenotype differencie des lignees obtenues est tres variable, particulierement pour le collagene de type ii, l'un des marqueurs principaux de la differenciation du c

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38

Delgado, Charris Jean-Paul. "Caractérisation phénotypique et moléculaire des cellules progénitrices foetales hépatiques simiennes et humaines." Paris 11, 2006. http://www.theses.fr/2006PA114825.

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Le foie est un organe de cible pour les thérapies cellulaires. Les perspectives de ces approches avec les hépatocytes humains adultes sont limitées : manque de données, absence de prolifération, et inefficacité de greffe. Nous avons caractérisé phénotypiquement à différents doublements de population (DP) une lignée d’hépatoblastes bipotents de singe immortalisés (IPFLS) dans le laboratoire à l’aide de l’oncogène T de SV40 flanqué de sites LoxP. Nous avons montré que l’immortalisation était réversible après excision du transgène par transduction rétrovirale du gène codant la Cre recombinase. No

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39

Kan, Chin Yi Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Human Papillomavirus in human breast cancer and cellular immortalisation." 2007. http://handle.unsw.edu.au/1959.4/40593.

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Human Papillomavirus (HPV) is a small, double stranded DNA tumour virus. Infection with HPV normally results in formation of warts. Certain types of HPV, such as type -16 and -18, are shown to have a causal role in the development of uterine cervical cancer, and are so called high risk type HPV. Recently, a role of HPV in breast cancer has been suggested, although a causal role for HPVs in human breast cancer is yet to be demonstrated. The first part of this study investigates the association of HPV with human breast cancer. The results demonstrate that 48% of breast cancers that occurred in A

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40

Keough, Rebecca Anne. "An investigation of hair follicle cell immortalisation and hair keratin gene regulation / Rebbeca Anne Keough." Thesis, 1995. http://hdl.handle.net/2440/18632.

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Bibliography: leaves 87-113.<br>xi, 113, [72] leaves, [42] leaves of plates : ill. (some col.) ; 30 cm.<br>Presents results from an investigation into the regulation of hair-specific gene expression, including attempts to produce an immortalised hair follicle cortical cell line for this purpose and the use of mouse transgenesis and invitro gel mobility shift assays.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry, 1995

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41

Veillette, François. "Caractérisation de HTDE et de son potentiel oncogénique in vitro et in vivo." Thèse, 2004. http://hdl.handle.net/1866/15541.

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42

Rodier, Francis. "Étude moléculaire des événements associés à la transformation par l'antigène grand T du virus de polyome (PyLT-Ag) = An analysis of molecular events associated with transformation by polyomavirus large T antigen (PyLT-Ag)." Thèse, 2004. http://hdl.handle.net/1866/15532.

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43

Löfqvist, Madelaine [Verfasser]. "The role of Epstein-Barr virus nuclear antigen 3C in the immortalisation process of primary human B-lymphocytes / von Madelaine Löfqvist." 2004. http://d-nb.info/972056904/34.

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44

Hajj, Hassan Houssein. "Établissement d'une lignée cellulaire pro-érythroïde de souris : outil d'étude de la régulation transcriptionnelle des gènes de globine." Thèse, 2004. http://hdl.handle.net/1866/14663.

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