Log in

Relevant bibliographies by topics / Imidazo[1,2-b]pyridazines / Journal articles

To see the other types of publications on this topic, follow the link: Imidazo[1,2-b]pyridazines.

Journal articles on the topic 'Imidazo[1,2-b]pyridazines'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Imidazo[1,2-b]pyridazines.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Barlin, GB, LP Davies, SJ Ireland, MML Ngu, and JK Zhang. "Imidazo[1,2-b]pyridazines. XII. Syntheses and Central Nervous System Activities of Some Substituted Imidazo[1,2-b]pyridazines and Related Imidazo[1,2-a]pyridines, Imidazo[1,2-a]pyrimidines and Imidazo[1,2-a]pyrazines." Australian Journal of Chemistry 45, no. 5 (1992): 877. http://dx.doi.org/10.1071/ch9920877.

Full text

Abstract:

Syntheses are reported for some 6-chloro(alkoxy,alkylthio and pheny1thio)-3-benzamidomethyl-(acetamidomethyl and methoxy)-2-arylimidazo[1,2-apyridines and some corresponding imidazo- [1,2- b]pyridazines, imidazo[1,2-a[pyrimidines and imidazo[l,2-a]pyrazines. IC50 values (or percentage displacement) are reported and discussed for the displacement of [3H]diazepam from rat brain membrane by each of these compounds. The imidazo[l,2-a[pyridines were generally slightly less potent than the imidazo[l,2- b]pyridazines but considerably more potent than the corresponding imidazo[1,2-a]pyrimidines or imidazo[1,2- a[pyrazines. Substitution of a 2-aryl group by a 2-alkyl group in imidazo[l,2- b]pyridazines led to a significant loss of activity.

APA, Harvard, Vancouver, ISO, and other styles

2

Barlin, GB, LP Davies, B. Glenn, PW Harrison, and SJ Ireland. "Imidazo[1,2-b]pyridazines. XV. Synthesis and Anxiolytic Activity of Some 3-(Benzamidomethyl and fluorobenzamidomethyl)-6-(fluoro, chloro and methylthio)-2-(4-tolyl and 3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 47, no. 4 (1994): 609. http://dx.doi.org/10.1071/ch9940609.

Full text

Abstract:

Syntheses are reported for some 3-( benzamido-and fluorobenzamido -methyl)-6-( fluoro , chloro and methylthio )-2(4-methyl-, 4-t-butyl-, 4-cyclohexyl- and 3,4-methylenedioxy-phenyl) imidazo-[1,2-b] pyridazines from the relevant 3-unsubstituted imidazo [1,2-b] pyridazines and the N-( hydroxymethyl ) benzamides. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(3- or 4-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl)-6-methylthioimidazo[1,2-b]- pyridazine bound most strongly, with IC50 2nM; but in behavioural tests in rats the most active compounds were 6-chloro(and methylthio )-3-(2-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl) imidazo [1,2-b] pyridazines which showed a significant anxiolytic activity at 2.5 mg/kg.

APA, Harvard, Vancouver, ISO, and other styles

3

DaVies, Les P., Gordon B. Barlin, Stephen J. Ireland, and Maria M. L. Ngu. "Substituted imidazo[1,2-b]pyridazines." Biochemical Pharmacology 44, no. 8 (October 1992): 1555–61. http://dx.doi.org/10.1016/0006-2952(92)90472-u.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Barlin, Gordon B., Les P. Davies, and Peter W. Harrison. "Imidazo[1,2-b]pyridazines. XXI. Syntheses of some 3-Acylaminomethyl-6-(chloro and iodo)- 2-(substituted phenyl)-imidazo[1,2-b]pyridazines and -imidazo[1,2-a]pyridines and their Interaction with Central and Mitochondrial Benzodiazepine." Australian Journal of Chemistry 50, no. 1 (1997): 61. http://dx.doi.org/10.1071/c96130.

Full text

Abstract:

A series of 3-acylaminomethyl-6-(chloro, iodo and methyl)-2-(phenyl, 4′-t-butylphenyl, 4′-cyclohexyl- phenyl, biphenyl-4′-yl, 4′-chlorophenyl and 4′-iodophenyl)imidazo[1,2-b]pyridazines and imidazo[1,2- a]pyridines has been prepared and examined for interaction with central and mitochondrial (peripheral- type) benzodiazepine receptors. The imidazo[1,2-b]pyridazines were generally more selective for the mitochondrial receptors than the corresponding imidazo[1,2-a]pyridines. Of these compounds, 3- acetamidomethyl-2-(biphenyl-4′-yl)-6-chloroimidazo[1,2-b]pyridazine (9) proved to be the most selective in studies of the displacement of [3H]diazepam from peripheral-type and central benzodiazepine receptors (IC50 2·8 nM and 0% displacement at 1000 nM, respectively).

APA, Harvard, Vancouver, ISO, and other styles

5

Barlin, GB, LP Davies, PW Harrison, NW Jacobsen, and AC Willis. "Imidazo[1,2-b]Pyridazines. XVI. Synthesis and Central Nervous System Activities of Some 6-(Chloro, Alkylthio, Phenylthio, Benzylthio or Pyridinylmethylthio)-3-(unsubstituted, benzamidomethyl or methoxy)-2-(styryl or benzoyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 47, no. 11 (1994): 1989. http://dx.doi.org/10.1071/ch9941989.

Full text

Abstract:

Some 6-( chloro, alkylthio, phenylthio, benzylthio or pyridinylmethylthio )-3-( unsubstituted , benzamidomethyl or methoxy )-2-styrylimidazo[1,2-b] pyridazines and 6-chloro-3-( unsubstituted and benzamidomethyl )-2-benzoylimidazo[1,2-b] pyridazines have been prepared and tested for their ability to displace [3H]diazepam from rat brain plasma membranes. The structures of 6-chloro-2-benzoyl[and 6-fluoro-2-(4′-tolyl)] imidazo [1,2-b] pyridazine have been confirmed by X-ray analyses. The reactions of 6-methylthio(and 6-phenylthio)pyridazin-3-amines with 3-bromo-1-phenylpropane-1,2-dione also have been investigated. The 6-substituted 3-unsubstituted 2-styryl(and benzoyl ) imidazo [1,2-b] pyridazines did not bind strongly to rat brain benzodiazepine receptors; nor did the 3-benzamidomethyl or 3-methoxy derivatives (cf. the 2-phenyl analogues). However, 3-benzamidomethyl-6-(pyridin-3-ylmethylthio)-2-styrylimidazo[1,2-b] pyridazine was an exception with IC50 68 nM.

APA, Harvard, Vancouver, ISO, and other styles

6

Barlin, GB. "Imidazo[1,2-B]Pyridazines. I. Some 3-Alkoxy-6-Halogeno-2-Phenyl-(and 4′-Substituted Phenyl)Imidazo[1,2-B]Pyridazines and 3-Methoxy-2,6-Diphenylimidazo[1,2-B]Pyridazine." Australian Journal of Chemistry 39, no. 11 (1986): 1803. http://dx.doi.org/10.1071/ch9861803.

Full text

Abstract:

A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl) imidazo [1,2-b] pyridazines (1) and 3-methoxy-2,6- diphenylimidazo [1,2-b] pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O- alkylation of the corresponding imidazo [1,2-b]pyridazin-3(5H)-ones with diazoalkanes. 6- Chloro-3-methoxy-2-phenylimidazo[2,1-a] phthal-azine was prepared similarly.

APA, Harvard, Vancouver, ISO, and other styles

7

Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XIV. Syntheses and Central Nervous System Activities of Some 6-(Methoxy-, dimethoxy-, methylenedioxy-, chloro- and fluoro-)-3-alkoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 46, no. 3 (1993): 353. http://dx.doi.org/10.1071/ch9930353.

Full text

Abstract:

Syntheses are reported for 28 new 3-alkoxy-6-(3′-methoxy-,3′,4′-dimethoxy, 3′,4′-methylene-dioxy-, 2′- and 4′-chloro- and 4′-fluoro-benzylamino)-2-phenyl(and substituted phenyl) imidazo -[1,2-b] pyridazines from the corresponding 6-substituted pyridazin-3-amine 2-oxides with α- bromoacetophenones, followed by alkylation of the intermediate 3-hydroxyimidazo[1,2-b] pyridazines. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(2′-ethoxyethoxy)-6(3′-methoxybenzylamino)-2-phenyl- and 6(3′,4′-methylenedioxybenzylamino )-2-(3″,4″-methylenedioxyphenyl)-3-methoxy-imidazo[1,2-b] pyridazine bound most strongly, with IC50 values of 1nM.

APA, Harvard, Vancouver, ISO, and other styles

8

Barlin, GB, LP Davies, and SJ Ireland. "Imidazo[1,2-b]Pyridazines. XIX. Syntheses and Central Nervous System Activities of Some 6-Arylthio(aryloxy and alkylthio)-3-(acetamidomethyl, benzamidomethyl, methoxy and unsubstituted)-2-arylimidazo[1,2-b]pyridazines." Australian Journal of Chemistry 49, no. 4 (1996): 443. http://dx.doi.org/10.1071/ch9960443.

Full text

Abstract:

Some 6-arylthio( aryloxy and alkylthio )-3-( acetamidomethyl , benzamidomethyl, methoxy and unsubstituted )-2-arylimidazo[1,2-b] pyridazines have been prepared and examined for their ability to displace [3H]diazepam from rat brain membranes. The most active compound was 3-acetamidomethyl-2-(3',4'-methylenedioxyphenyl)-6-phenylthioimidazo[1,2-b] pyridazine with IC50 4.4 nM. The 3-acylaminomethyl-6-(2- and 3-methoxyphenylthio)-2-phenylimidazo[1,2-b] pyridazines proved less active than their 6-phenylthio analogues, and larger substituents at the 2- and 6-positions markedly decreased binding. Significant differences in binding ability have been observed between 3-acylaminomethyl-2-aryl-6-phenylthioimidazo[1,2-b] pyridazines and the corresponding imidazo [1,2-a]pyridines.

APA, Harvard, Vancouver, ISO, and other styles

9

Barlin, GB, LP Davies, SJ Ireland, CLY Khoo, and TMT Nguyen. "Imidazo[1,2-B]pyridazines. IX. Syntheses and Central Nervous System Activities of Some 3-Alkoxy-6-(o-alkoxy, o-methylthio- or o-fluoro-phenoxy)-2-arylimidazo[1,2-b]pyridazines." Australian Journal of Chemistry 43, no. 3 (1990): 503. http://dx.doi.org/10.1071/ch9900503.

Full text

Abstract:

Syntheses are reported for a series of 6-(o-methoxy -, o-ethoxy -, o-methylthio - and o-fluoro-phenoxy )-3-( methoxy and ethoxy )-2- phenyl(substituted phenyl and pyridin-3″-yl) imidazo [1,2-b] pyridazines . IC50 values are reported for the displacement of 3H-diazepam from rat brain membrane by each of these compounds. The most active compounds were found to be 3-ethoxy-2-(p- fluorophenyl )-6-(o- methoxyphenoxy )-, 3-methoxy-6-(o- methoxyphenoxy )-2-(m-nitrophenyl )- and 3-methoxy-6-(o- methoxyphenoxy )-2-(3″,4″-methylenedioxy ) imidazo [1,2-b] pyridazines with IC5O values of 15, 18 and 19 nM respectively.

APA, Harvard, Vancouver, ISO, and other styles

10

Schmitt, Martine, Jean-Jacques Bourguignon, Gordon B. Barlin, and Les P. Davies. "Imidazo[1,2-b]pyridazines. XXIV Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b] pyridazines, 6-Substituted 2-Benzoyl- imidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin- 5-ium-3-olates and their Interaction with Central and Mitochondrial Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 8 (1997): 779. http://dx.doi.org/10.1071/c97030.

Full text

Abstract:

The syntheses of some ethyl 2-{2′-aryl-6′-(chloro, iodo and methoxy)imidazo[1,2-b]pyridazin-3′-yl}-2-(acetoxy, acylamino, hydroxy and methoxy)acetates, 6-methyl-2-(p-tolyl)- and 6-chloro-2-(4′-chlorophenyl)-3-trimethylammoniomethylimidazo[1,2-b]pyridazine iodides (and reactions thereof), 2-benzoyl 6-substituted imidazo[1,2-b]pyridazines and 7-(methoxy, chloro and phenylthio)-2-phenylpyrimido-[1,2-b]pyridazin-5-ium-3-olates are reported. The ability of these compounds to displace [3H]diazepam from rat forebrain membrane [central benzodiazepine receptor (BZR)] and rat kidney membrane [mitochondrial (peripheral-type) benzodiazepine receptor (PBR)] has been examined. The most active compound was ethyl 2-{6′-chloro-2′-(p-tolyl)imidazo[1,2-b]pyridazin-3′-yl}-2-hydroxyacetate with IC50 24 nM for displacement from the BZR and 91% displacement at 1000 nM from the PBR; the most selective for the PBR was 6-methyl-3-methylsulfonylmethyl-2-(p-tolyl)imidazo[1,2-b]pyridazine (PBR, IC50 92 nM; BZR, 15% inhibition of binding by [3H]diazepam at 1000 nM).

APA, Harvard, Vancouver, ISO, and other styles

11

Barlin, GB, LP Davies, and PW Harrison. "Imidazo[1,2-b]Pyridazines. XVIII. Syntheses and Central Nervous System Activities of Some 6-, 7- and 8-(Chloro and methoxy)imidazo[1,2-a]pyridine Analogs." Australian Journal of Chemistry 48, no. 5 (1995): 1031. http://dx.doi.org/10.1071/ch9951031.

Full text

Abstract:

Syntheses are reported for some 2-aryl-3-(benzamidomethyl and methoxy)-6(7 and 8)-chloro- and 6(and 8)-methoxy-imidazo[1,2-a]pyridines. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, those with 6-chloro and 6-methoxy groups bound most strongly, and relatively small differences only were observed between corresponding imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines.

APA, Harvard, Vancouver, ISO, and other styles

12

M., Sumakanth, V. Malla Reddy, V. S. H. Krishnan, and B. S. Sastry. "Synthesis of Some New Imidazo[1,2-b] Pyridazines." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (May 31, 2009): 471–76. http://dx.doi.org/10.37285/ijpsn.2009.2.1.14.

Full text

Abstract:

Several 2,6-diaryl-imidazo[1,2-b]pyridazines (5 & 7) were prepared from 3-amino-6-aryl-pyridazines (3) which in turn were obtained from the corresponding 6-aryl-pyridazine-3(2H)-ones(1) via., 6-aryl-pyridazin-3(2H)-thiones (2) as intermediates, by a reaction with an appropriate a-halocarbonyl compounds (4) or a-haloacyl carbamates (6) in a suitable solvent at reflux temperature. The resulted products were characterized by their physical, analytical and spectral data.

APA, Harvard, Vancouver, ISO, and other styles

13

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-B]Pyridazines. III. Syntheses and Central Nervous-System Activities of Some 6-Chloro-3-methoxy (and ethoxy)-2-aryl (and heteroaryl)imidazo[1,2-B]pyridazines." Australian Journal of Chemistry 41, no. 8 (1988): 1149. http://dx.doi.org/10.1071/ch9881149.

Full text

Abstract:

The synthesis of a series of 6-chloro-3-methoxy(and ethoxy )-2- phenyl[and (variously substituted phenyl), thienyl, and naphthalenyl ] imidazo [1,2-b] pyridazines and a 6-fluoro analogue are reported. These compounds were tested for their ability to displace [3H]diazepam bound to washed rat brain plasma membranes. Under standard assay conditions (see Experimental) and in the presence of 100 μM γ- aminobutyric acid, 6-chloro-3-methoxy-2-(p-tolyl ) imidazo [1,2- b] pyridazine was the most active compound with an IC50 value of 148 nM (cf. diazepam, with IC50 of 4.2 nM).

APA, Harvard, Vancouver, ISO, and other styles

14

Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XIII. Syntheses and Central Nervous System Activities of Some 2-Benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-Butyl and cyclohexyl)-3-methoxy(acylaminomethyl and dimethylaminomethyl)-6-(variously substituted)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 8 (1992): 1281. http://dx.doi.org/10.1071/ch9921281.

Full text

Abstract:

6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethy1)-2-benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)imidazo[1,2-b] pyridazines have been prepared and examined for activity in the central nervous system. Of these, 2-benzyl-3-methoxy-6-(3'-methoxybenzylamino) imidazo[1,2-b]pyridazine (IC50 88nM) bound most strongly to rat brain membrane. In general, the order of activity for groups at the 2-position was Ph > PhCH2 > PhCH2CH2 > C6H4Ph-p, 6'-methylnaphthalen-2'-yl, c-C6H11 or But.

APA, Harvard, Vancouver, ISO, and other styles

15

Barlin, Gordon B., Les P. Davies, Stephen J. Ireland, and Maria M. L. Ngu-Schwemlein. "Imidazo[1,2-b]pyridazines. XXII. Syntheses of Some 2-Aryl-3-methoxy-6-(pyridinylmethylthio and pyridinylmethylamino)imidazo[1,2-b]pyridazines and Their Interaction with Central and Mitochondrial (Peripheral-Type) Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 2 (1997): 91. http://dx.doi.org/10.1071/c96136.

Full text

Abstract:

2-Aryl-3-methoxy-6-(pyridinylmethylthio and pyridinylmethylamino)imidazo[1,2-b]pyridazines have been prepared and examined as ligands for benzodiazepine receptors. Most were highly effective in displacing [3H]diazepam from central benzodiazepine receptors present in rat brain membranes but showed little capacity for its displacement from mitochondrial (peripheral-type) benzodiazepine receptors present in rat kidney membranes. For example, 3-methoxy-2-(3′,4′-methylenedioxyphenyl)-6-(pyridin-2′′-ylmethylthio)imidazo[1,2-b]pyridazine had an IC50 value of 1 · 7 nM for central receptors but gave only 39% displacement at 1000 nM for mitochondrial receptors. Of all the compounds described in this series of papers, 3-methoxy-6-(2′-methoxybenzylamino)-2-(3′′,4′′-methylenedioxyphenyl)imidazo[1,2-b]pyridazine was the most active in displacing [3H]diazepam from central receptors (IC50 0·3 nM), and it had a low affinity for mitochondrial receptors (40% displacement of [3H]diazepam at 1000 nM).

APA, Harvard, Vancouver, ISO, and other styles

16

BARLIN, G. B., L. P. DAVIES, S. J. IRELAND, M. M. L. NGU, and J. ZHANG. "ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 12. Syntheses and Central Nervous System Activities of Some Substituted Imidazo(1,2-b)pyridazines and Related Imidazo(1,2-a)pyridines, Imidazo(1,2-a)pyrimidines and Imidazo( 1,2-a)pyrazines." ChemInform 23, no. 34 (August 21, 2010): no. http://dx.doi.org/10.1002/chin.199234175.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Barlin, GB, and SJ Ireland. "Imidazo[1,2-B]pyridazines. II. 6-Alkylthio and 6-Arylthio-3-methoxy-2-phenylimidazo[1,2-b]pyridazines." Australian Journal of Chemistry 40, no. 8 (1987): 1491. http://dx.doi.org/10.1071/ch9871491.

Full text

Abstract:

A series of 6-alkylthio- and 6-arylthio-3-methoxy-2-phenylimidazo[l,2- b]pyridazines has been prepared from 6-alkylthio-and 6-arylthio-pyridazin-3-amines through the corresponding 6-alkylthio-and 6-arylthio-2-phenylimidazo[l,2-b] pyridazin-3(5H)-ones.

APA, Harvard, Vancouver, ISO, and other styles

18

Behbehani, Haider, and Hamada Mohamed Ibrahim. "Microwave-assisted synthesis in water: first one-pot synthesis of a novel class of polysubstituted benzo[4,5]imidazo[1,2-b]pyridazines via intramolecular SNAr." RSC Advances 5, no. 108 (2015): 89226–37. http://dx.doi.org/10.1039/c5ra17313b.

Full text

Abstract:

A novel and straightforward one-pot synthesis protocol has been developed for the synthesis of benzo[4,5]imidazo[1,2-b]pyridazines through intramolecular S_NAr, utilizing water as a green solvent and microwaves as an efficient green energy source.

APA, Harvard, Vancouver, ISO, and other styles

19

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-b]Pyridazines. VIII. Syntheses and Central Nervous System Activities of Some 6-Benzylamino (and methoxybenzylamino)-3-methoxy-2-phenyl(Substituted phenyl or pyridinyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 42, no. 10 (1989): 1759. http://dx.doi.org/10.1071/ch9891759.

Full text

Abstract:

Syntheses and IC50 values for the displacement of 3H-diazepam from rat brain plasma membrane are reported for a series of 6-benzylamino(and methoxybenzylamino )-3-methoxy-2-phenyl(substituted phenyl and pyridinyl )imidazo[l,2-b]pyridazines (and their 6-anilino and 6-phenethylamino analogues). The results are compared with those reported previously (by us) for the 6-chloro, 6-phenoxy, 6-benzylthio, and 6-benzyloxy compounds. In the imidazo[l,2-b]pyridazine ring system, 6-(o- and m- methoxybenzylamino ) groups were found to be beneficial to binding activity; eight compounds have been prepared with IC50 values less than 2 nM (cf. 3H-diazepam with IC50 of 4.2 nM ).2-(p-Aminopheny1)-3-methoxy- 6-(m- methoxybenzylamino )imidazo[1,2-b]pyridazine exhibited the highest activity with IC50 1.0 nM.

APA, Harvard, Vancouver, ISO, and other styles

20

Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XI. Syntheses and Central Nervous System Activities of Some 6-(N-Benzyl-N-methylamino)-3-methoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 4 (1992): 751. http://dx.doi.org/10.1071/ch9920751.

Full text

Abstract:

Syntheses are reported for 196-(N-benzyl-N-methylamino )-3-methoxy-2-phenyl(and substituted phenyl or pyridinyl ) imidazo [1,2-b] pyridazines from 6-(N-benzyl-N-methylamino)pyridazin-3- amine 2-oxide. The ability of each of these compounds to displace [3H]diazepam from rat brain membrane preparations was measured and the IC50 values (or percentage displacements) are reported and discussed. 6-(N-Benzyl-N-methylamino )-3-methoxy-2-phenylimido[1,2-b]pyridine was about half as active as its 6-bemylamino analogue, and the most active compound was 6-(N-benzyl-N-methylamino )-2-(2'-fluorophenyl)-3-methoxyimido[1,2-b] pyridazine with IC50 9.8 nM.

APA, Harvard, Vancouver, ISO, and other styles

21

Matyus, P., GB Barlin, PW Harrison, MG Wong, and LP Davies. "Ligands for the Central Benzodiazepine Receptor: Structure - Affinity Relationship Studies on Imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 49, no. 4 (1996): 435. http://dx.doi.org/10.1071/ch9960435.

Full text

Abstract:

Seventy-six imidazo [1,2-b] pyridazines and some bicyclic isomers have been analysed and compared in terms of geometric and electronic requirements for binding to central benzodiazepine receptors. The binding sites identified for these compounds by molecular modelling are consistent with known benzodiazepine receptor- ligand interaction models. However, for the most active compounds, additional binding sites are proposed.

APA, Harvard, Vancouver, ISO, and other styles

22

Barlin, GB, LP Davies, RA Davis, and PW Harrison. "Imidazo[1,2-b]pyridazines. XVII. Synthesis and Central Nervous System Activity of Some 6-(Alkylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines Containing Methoxy, Methylenedioxy and Methyl Substituents." Australian Journal of Chemistry 47, no. 11 (1994): 2001. http://dx.doi.org/10.1071/ch9942001.

Full text

Abstract:

Syntheses are reported for 6-( methylthio, ethylthio, propylthio, substituted benzylthio and chloro )-3-( methoxy, unsubstituted and benzamidomethyl )-2-arylimidazo[1,2-b] pyridazines containing methoxy, methylenedioxy and methyl groups attached to phenyl substituents . In tests of the ability of these compounds to displace [3H]diazepam from rat brain membranes, 3-methoxy-6-(3′,4′-methylenedioxybenzylthio)-2- (3′,4′-methylenedioxyphenyl) imidazo [1,2-b] pyridazine (IC50 1 nM) bound most strongly; methylenedioxy groups were beneficial to activity whereas polymethoxy or dimethyl substituents were generally detrimental.

APA, Harvard, Vancouver, ISO, and other styles

23

Barlin, GB, LP Davies, SJ Ireland, MML Ngu, and JK Zhang. "Imidazo[1,2-b]pyridazines. X. Syntheses and Central Nervous System Activities of Some 3-(Acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 4 (1992): 731. http://dx.doi.org/10.1071/ch9920731.

Full text

Abstract:

Syntheses of some 3-( acetamido, benzamido , substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6( halogeno, alkylthio, alkoxy, phenylthio, phenoxy , benzylthio or benzyloxy ) imidazo [1,2-b] pyridazines from the 3-unsubstituted analogues are described. The IC50 values (or percentage displacements) are reported and discussed for the displacement of [3H]diazepam from rat brain membrane by each of these compounds. .The 3-benzamidomethyl compounds were generally the most active; of these, 3-benzamidomethyl-2-(3',4'-methylenedioxyphenyl)-6-methylthioimido[1,2-b] pyridazine showed outstanding activity with IC50 2 nM .

APA, Harvard, Vancouver, ISO, and other styles

24

SCHMITT, M., J. J. BOURGUIGNON, G. B. BARLIN, and L. P. DAVIES. "ChemInform Abstract: Imidazo[1,2-b]pyridazines. Part 24. Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b]pyridazines, 6-Substituted 2-Benzoylimidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin-5-ium-3-olates and Their Interaction with Central." ChemInform 29, no. 6 (June 24, 2010): no. http://dx.doi.org/10.1002/chin.199806186.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Raboisson, Pierre, Belew Mekonnen, and Norton P. Peet. "Efficient preparation of imidazo[1,2-b]pyridazines under Swern oxidative conditions." Tetrahedron Letters 44, no. 14 (March 2003): 2919–21. http://dx.doi.org/10.1016/s0040-4039(03)00426-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Barlin, GB, LP Davies, PW Harrison, SJ Ireland, and AC Willis. "Imidazo[1,2-b]Pyridazines. XXI. Syntheses of Some 3-Acylaminomethyl-6-(chloro, fluoro, methoxy, methylthio, phenoxy and phenylthio)-2-(phenyl, 4-t-butylphenyl, 4-cyclohexylphenyl, β-naphthyl and styryl)imidazo[1,2-b]pyridazines and Their Interaction With Central and Peripheral-Type Benzodiazepine Receptors." Australian Journal of Chemistry 49, no. 4 (1996): 451. http://dx.doi.org/10.1071/ch9960451.

Full text

Abstract:

Some 3-(aliphatic and aromatic) acylaminomethyl derivatives of 6-( chloro, fluoro, methoxy, methylthio, phenoxy and phenylthio )-2-(phenyl, 4-t-butylphenyl, 4-cyclohexylphenyl, β- naphthyl and styryl ) imidazo [1,2-b] pyridazines have been prepared and tested for binding to central benzodiazepine receptors present in rat brain membrane, and to peripheral-type (mitochondrial) benzodiazepine receptors present in rat kidney membrane. Some of these compounds which contained 2-(4-t-butylphenyl, 4-cyclohexylphenyl and styryl ) substituents bound strongly and selectively to peripheral-type benzodiazepine receptors. For example, 2-(4′-t-butylphenyl)-6-chloro-2-(4″-fluorobenzamidomethyl) imidazo [1,2-b] pyridazine in tests for the displacement of [3H]diazepam from both peripheral-type and central benzodiazepine receptors gave IC50 <1.0 nM and 9% displacement at 1000 nM , respectively. Steric effects appeared to be more restrictive in the interaction of these ligands with central benzodiazepine receptors rather than with peripheral-type benzodiazepine receptors; X-ray structure analyses of two typical compounds are reported.

APA, Harvard, Vancouver, ISO, and other styles

27

Mourad, Alaa E., Dean S. Wise, and Leroy B. Townsend. "Synthesis of imidazo[1,2-b]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivatives." Journal of Heterocyclic Chemistry 30, no. 5 (October 1993): 1365–72. http://dx.doi.org/10.1002/jhet.5570300531.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-b]pyridazines. VII. Syntheses and Central Nervous System Activities of Some 3-Alkoxy-6-benzyloxy (and methoxy-benzyloxy)-2-phenyl(substituted phenyl or pyridinyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 42, no. 10 (1989): 1749. http://dx.doi.org/10.1071/ch9891749.

Full text

Abstract:

A series of 15 3-alkoxy-6-benzyloxy( methoxybenzyloxy )-2-phenyl( sbstitted phenyl and pyridinyl )imidazo[l,2-b]pyridazines has been prepared and each compound tested for its ability to displace 3H-diazepam from rat brain plasma membranes. The results have been compared with data previously obtained for other derivatives of this ring system. Compounds containing 6(o- or m- methoxybenzyloxy ) groups were more effective in the displacement of 3H-diazepam than those with the 6-benzyloxy group; and the most active compound was 2-(p- fluorophenyl )-3-methoxy-6-(m- methoxybenzyloxy )imidazo[l,2 b]pyridazine with IC50 1.5 nM.

APA, Harvard, Vancouver, ISO, and other styles

29

BARLIN, G. B., L. P. DAVIES, and P. W. HARRISON. "ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 21. Syntheses of Some 3- Acylaminomethyl-6-(chloro and iodo)-2-(substituted phenyl)-imidazo(1,2- b)pyridazines and imidazo(1,2-a)pyridines and Their Interaction with Central and Mitochondrial Benzodiaze." ChemInform 28, no. 29 (August 3, 2010): no. http://dx.doi.org/10.1002/chin.199729142.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Barlin, GB, LP Davies, SJ Ireland, and MML Ngu. "Imidazo[1,2-b]Pyridazines. V. Syntheses and Central Nervous Activities of Some 3-Alkoxy-6-benzylthio(substituted benzylthio and Other phenylalkylthio)-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 42, no. 7 (1989): 1133. http://dx.doi.org/10.1071/ch9891133.

Full text

Abstract:

Syntheses are reported for a number of 3-alkoxy-6-benzylthio(substituted benzylthio and other phenylalkylthio )-2-phenyl(and substituted phenyl)imidazo[l,2-b]pyridazines. These compounds were then examined for their ability to displace 3H-diazepam from rat brain membranes. In preliminary tests, in the presence of 100 �m γ- aminobutyric acid (GABA) and under standard assay conditions (see Experimental), 6-benzylthio-3-methoxy-2-phenylimidazo[l,2- b]pyridazine gave an lC50 value of 25nM (IC50 for unlabelled diazepam is 4.3 nM ); its 6-(m- aminophenyl ), 6-(p- aminophenyl ) and 6-(m- nitrophenyl ) analogues gave values of 15, 9 and 8 nM respectively.

APA, Harvard, Vancouver, ISO, and other styles

31

Aziz, Jessy, and Sandrine Piguel. "An Update on Direct C–H Bond Functionalization of Nitrogen-Containing Fused Heterocycles." Synthesis 49, no. 20 (August 25, 2017): 4562–85. http://dx.doi.org/10.1055/s-0036-1590859.

Full text

Abstract:

This report highlights the recent advances in direct C–H bond functionalization of 5,5- and 6,5-fused heterocycles containing at least two nitrogen atoms. Besides C–C bond formation, C–N, C–S, C–P, and C–Si bonds can also be created via a metal-catalyzed process. Some examples, where a C–H functionalization approach was applied for the synthesis of drug candidates, will be presented as well.1 Introduction2 C–H Functionalization Reactions of N-Containing Heterocycles2.1 Imidazo[1,2-a]pyridines2.2 Pyrrolo[1,2-a]pyrazines2.3 Imidazo[1,2-b]pyrazoles2.4 Imidazo[1,2-a]pyrimidines2.5 Imidazo[1,2-a]pyrazines and Imidazo[1,5-a]pyrazines2.6 Imidazo[1,2-b]pyridazines2.7 Imidazo[4,5-b]pyridines and Imidazo[4,5-c]pyridines2.8 Pyrazolo[3,4-b]pyridines2.9 Pyrazolo[1,5-a]pyrimidines2.10 Pyrrolo[2,3-d]pyrimidines and Pyrrolo[3,2-d]pyrimidines2.11 Imidazo[1,2-b][1,2,4]triazines2.12 Imidazo[1,2-b][1,2,4,5]tetrazines3 Outlook4 Conclusion

APA, Harvard, Vancouver, ISO, and other styles

32

MOURAD, A. E., D. S. WISE, and L. B. TOWNSEND. "ChemInform Abstract: Synthesis of Imidazo(1,2-b)pyridazines: Fenbendazole, Oxifenbendazole Analogues and Related Derivatives." ChemInform 25, no. 16 (August 19, 2010): no. http://dx.doi.org/10.1002/chin.199416190.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Byth, Kate F., Nicola Cooper, Janet D. Culshaw, David W. Heaton, Sandra E. Oakes, Claire A. Minshull, Richard A. Norman, et al. "Imidazo[1,2- b ]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors." Bioorganic & Medicinal Chemistry Letters 14, no. 9 (May 2004): 2249–52. http://dx.doi.org/10.1016/j.bmcl.2004.02.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Barlin, GB, LP Davies, SJ Ireland, and MML Ngu. "Imidazo[1,2-b]Pyridazines. VI. Syntheses and Central Nervous System Activities of Some 6-(Alkoxy- and Methylthio-phenoxy and Methoxybenzylthio)-3-methoxy-2-phenyl(substituted phenyl and pyridinyl)Imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 42, no. 10 (1989): 1735. http://dx.doi.org/10.1071/ch9891735.

Full text

Abstract:

Series of 6-( alkoxy - and methylthio-phenoxy )-2-phenyl(substituted phenyl and pyridiny1)imidazo[l,2-b]pyridazines and 3-methoxy-6-( methoxybenzylthio )-2-phenyl(substituted phenyl and pyridinyl ) imidazo[l,2-b]pyridazines have been prepared and subsequently tested for their ability to inhibit GABA-stimulated 3H-diazepam binding to rat brain plasma membranes. The 6( alkoxy- and methylthio-phenoxy ) and 6-( methoxybenzylthio) compounds were much more effective in the displacement studies than the parent 6-phenoxy or 6-benzylthio compounds respectively. 3-Methoxy-6-(2′-methoxyphenoxy)-2-phenylimidazo[l,2-b]pyridazine (GBLD-167, IC50 70 nm) was 16 times more effective than its 3-methoxy-6-phenoxy analogue (GBLD-163, IC50 1120 nM ) and the 3-methoxy-6-(21-methoxybenzylthio)-2-phenyl compound (GELD-214, 1C50 9 nM ) was two and a half times more active than its 6-benzylthio-3-methoxy analogue (GBLD-137, IC50 22 nM ). The most active member of the 6-phenoxy series was the 2-(41-fluorophenyl)-3-methoxy-6- (2″-methoxyphenoxy) compound (GBLD-255, IC50 30 nM ) and, within the 6-benzylthio series, the 2-(4′-fluorophenyl, 3′-aminophenyl, and pyridin-31-yl)-3-methoxy-6-(3″-methoxybenzylthio) compounds (GBLD-233, 301 and 296) all gave IC50 5 nM. A Hansch -type analysis of the results for these two closely related series of compounds indicates that electron-donating substituents in 2-(para substituted phenyl) derivatives favour binding, but bulky substituents hinder this effect.

APA, Harvard, Vancouver, ISO, and other styles

35

BARLIN, G. B., L. P. DAVIES, S. J. IRELAND, and J. ZHANG. "ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 11. Syntheses and Central Nervous System Activities of Some 6-(N-Benzyl-N-methylamino)-3-methoxy-2- phenyl(and substituted phenyl)imidazo(1,2-b)pyridazines." ChemInform 23, no. 30 (August 21, 2010): no. http://dx.doi.org/10.1002/chin.199230168.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-b]pyridazines. IV. Syntheses and Central Nervous System Activities of Some 3-Methoxy-6-phenoxy(Substituted Phenoxy and Naphthyloxy)-2-phenylimidazo[1,2-b]pyridazines." Australian Journal of Chemistry 41, no. 11 (1988): 1735. http://dx.doi.org/10.1071/ch9881735.

Full text

Abstract:

Syntheses are reported for some 3-methoxy-6-phenoxy(substituted phenoxy and naphthyloxy )-2-phenylimidazo[1,2-b] pyridazines; they were made in order to study their possible pharmacological activity in the mammalian central and peripheral nervous system. In initial biological screens to detect compounds with potential activity at receptors for the benzodiazepine class of drugs, the most active compounds were 3-methoxy-6-(2′-methylthiophenoxy)- and 6-(2′-dimethylaminophenoxy )-3-methoxy-2-phenylimidazo[1,2-b] pyridazine. Their respective IC50 values for displacement of 3H-diazepam (IC50 for unlabelled diazepam, 4.2 nM ) from rat brain plasma membranes (measured in the presence of 100 μM GABA) were 112 and 149 nM.

APA, Harvard, Vancouver, ISO, and other styles

37

BARLIN, G. B., L. P. DAVIES, B. GLENN, P. W. HARRISON, and S. J. IRELAND. "ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 15. Synthesis and Anxiolytic Activity of Some 3-(Benzamidomethyl and fluorobenzamidomethyl)-6-(fluoro, chloro and methylthio)-2-(4-tolyl and 3,4-methylenedioxyphenyl)imidazo( 1,2-b)pyridazines." ChemInform 25, no. 32 (August 19, 2010): no. http://dx.doi.org/10.1002/chin.199432151.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

BARLIN, G. B., L. P. DAVIES, S. J. IRELAND, and M. M. L. NGU-SCHWEMLEIN. "ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 22. Syntheses of Some 2-Aryl-3-methoxy- 6-(pyridinylmethylthio and pyridinylmethylamino)imidazo(1,2-b) pyridazines and Their Interaction with Central and Mitochondrial ( Peripheral-Type) Benzodiazepine." ChemInform 28, no. 27 (August 3, 2010): no. http://dx.doi.org/10.1002/chin.199727165.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Hariss, Layal, Kamal Bou Hadir, Mirvat El-Masri, Thierry Roisnel, René Grée, and Ali Hachem. "Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains." Beilstein Journal of Organic Chemistry 13 (October 10, 2017): 2115–21. http://dx.doi.org/10.3762/bjoc.13.208.

Full text

Abstract:

Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity.

APA, Harvard, Vancouver, ISO, and other styles

40

Barlin, Gordon B. "Imidazo[1,2-b]pyridazines: Syntheses and interaction with central and peripheral-type (mitochondrial) benzodiazepine receptors." Journal of Heterocyclic Chemistry 35, no. 5 (September 1998): 1205–18. http://dx.doi.org/10.1002/jhet.5570350515.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Dumitraşcu, Florea, and Dan George Dumitrescu. "Pyrrolo[1,2-b]pyridazines. A revisit." Arkivoc 2008, no. 1 (November 16, 2008): 232–70. http://dx.doi.org/10.3998/ark.5550190.0009.109.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

BARLIN, G. B., L. P. DAVIES, S. J. IRELAND, and J. ZHANG. "ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 14. Syntheses and Central Nervous System Activities of Some 6-(Methoxy-, dimethoxy-, methylenedioxy-, chloro- and fluoro-benzylamino)-3-alkoxy-2-phenyl(and substituted phenyl)imidazo(1,2-b)pyridazines." ChemInform 24, no. 31 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199331189.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Zeng, Fanxing, David Alagille, Gilles D. Tamagnan, Brian J. Ciliax, Allan I. Levey, and Mark M. Goodman. "Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques." ACS Medicinal Chemistry Letters 1, no. 2 (March 11, 2010): 80–84. http://dx.doi.org/10.1021/ml100005j.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

El Akkaoui, Ahmed, Sabine Berteina-Raboin, Abderrahim Mouaddib, and Gérald Guillaumet. "Direct Arylation of Imidazo[1,2-b]pyridazines: Microwave-Assisted One-Pot Suzuki Coupling/Pd-Catalysed Arylation." European Journal of Organic Chemistry 2010, no. 5 (February 2010): 862–71. http://dx.doi.org/10.1002/ejoc.200900849.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Hervet, Maud, Christophe Galtier, CÉcile Enguehard, Alain Gueiffier, and Jean-Claude Debouzy. "Reactivity of 2-substituted imidazo[1,2-b]pyridazines: Preparation of 3-nitro, nitroso and chloro derivatives." Journal of Heterocyclic Chemistry 39, no. 4 (July 2002): 737–42. http://dx.doi.org/10.1002/jhet.5570390419.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Pogacic, Vanda, Alex N. Bullock, Oleg Fedorov, Panagis Filippakopoulos, Christelle Gasser, Andrea Biondi, Sandrine Meyer-Monard, Stefan Knapp, and Juerg Schwaller. "Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity." Cancer Research 67, no. 14 (July 15, 2007): 6916–24. http://dx.doi.org/10.1158/0008-5472.can-07-0320.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Farag, Ahmad M., and Kamal M. Dawood. "One-pot synthesis of imidazo[1,2-b]pyrazole, imidazo[1,2-b]-1,2,4-triazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, imidazo[1,2-a]benzimidazole, and 1,2,4-triazolo[4,3-a]benzimidazole derivatives." Heteroatom Chemistry 8, no. 2 (1997): 129–33. http://dx.doi.org/10.1002/(sici)1098-1071(1997)8:2<129::aid-hc4>3.0.co;2-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Pandit, Shivaji S., Mahesh R. Kulkarni, Usha Ghosh, Yashwant B. Pandit, and Nitin P. Lad. "Synthesis and biological evaluation of imidazo[1,2- $${{\varvec{b}}}$$ b ]pyridazines as inhibitors of TNF- $${\varvec{\upalpha }}$$ α production." Molecular Diversity 22, no. 3 (December 2, 2017): 545–60. http://dx.doi.org/10.1007/s11030-017-9798-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

El Akkaoui, A., J. Koubachi, S. El Kazzouli, S. Berteina-Raboin, A. Mouaddib, and G. Guillaumet. "Efficient and regioselective functionalization of imidazo[1,2-b]pyridazines via palladium-catalyzed cross-coupling reaction and SNAr." Tetrahedron Letters 49, no. 15 (April 2008): 2472–75. http://dx.doi.org/10.1016/j.tetlet.2008.02.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Barlin, Gordon B. "ChemInform Abstract: Imidazo[1,2-b]pyridazines: Syntheses and Interaction with Central and Peripheral-Type (Mitochondrial) Benzodiazepine Receptors." ChemInform 30, no. 10 (June 17, 2010): no. http://dx.doi.org/10.1002/chin.199910291.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!