Log in

Relevant bibliographies by topics / Imidazo[1,2-b]pyridazine / Journal articles

To see the other types of publications on this topic, follow the link: Imidazo[1,2-b]pyridazine.

Journal articles on the topic 'Imidazo[1,2-b]pyridazine'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Imidazo[1,2-b]pyridazine.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Schmitt, Martine, Jean-Jacques Bourguignon, Gordon B. Barlin, and Les P. Davies. "Imidazo[1,2-b]pyridazines. XXIV Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b] pyridazines, 6-Substituted 2-Benzoyl- imidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin- 5-ium-3-olates and their Interaction with Central and Mitochondrial Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 8 (1997): 779. http://dx.doi.org/10.1071/c97030.

Full text

Abstract:

The syntheses of some ethyl 2-{2′-aryl-6′-(chloro, iodo and methoxy)imidazo[1,2-b]pyridazin-3′-yl}-2-(acetoxy, acylamino, hydroxy and methoxy)acetates, 6-methyl-2-(p-tolyl)- and 6-chloro-2-(4′-chlorophenyl)-3-trimethylammoniomethylimidazo[1,2-b]pyridazine iodides (and reactions thereof), 2-benzoyl 6-substituted imidazo[1,2-b]pyridazines and 7-(methoxy, chloro and phenylthio)-2-phenylpyrimido-[1,2-b]pyridazin-5-ium-3-olates are reported. The ability of these compounds to displace [3H]diazepam from rat forebrain membrane [central benzodiazepine receptor (BZR)] and rat kidney membrane [mitochondrial (peripheral-type) benzodiazepine receptor (PBR)] has been examined. The most active compound was ethyl 2-{6′-chloro-2′-(p-tolyl)imidazo[1,2-b]pyridazin-3′-yl}-2-hydroxyacetate with IC50 24 nM for displacement from the BZR and 91% displacement at 1000 nM from the PBR; the most selective for the PBR was 6-methyl-3-methylsulfonylmethyl-2-(p-tolyl)imidazo[1,2-b]pyridazine (PBR, IC50 92 nM; BZR, 15% inhibition of binding by [3H]diazepam at 1000 nM).

APA, Harvard, Vancouver, ISO, and other styles

2

Barlin, GB. "Imidazo[1,2-B]Pyridazines. I. Some 3-Alkoxy-6-Halogeno-2-Phenyl-(and 4′-Substituted Phenyl)Imidazo[1,2-B]Pyridazines and 3-Methoxy-2,6-Diphenylimidazo[1,2-B]Pyridazine." Australian Journal of Chemistry 39, no. 11 (1986): 1803. http://dx.doi.org/10.1071/ch9861803.

Full text

Abstract:

A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl) imidazo [1,2-b] pyridazines (1) and 3-methoxy-2,6- diphenylimidazo [1,2-b] pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O- alkylation of the corresponding imidazo [1,2-b]pyridazin-3(5H)-ones with diazoalkanes. 6- Chloro-3-methoxy-2-phenylimidazo[2,1-a] phthal-azine was prepared similarly.

APA, Harvard, Vancouver, ISO, and other styles

3

Barlin, GB, LP Davies, PW Harrison, NW Jacobsen, and AC Willis. "Imidazo[1,2-b]Pyridazines. XVI. Synthesis and Central Nervous System Activities of Some 6-(Chloro, Alkylthio, Phenylthio, Benzylthio or Pyridinylmethylthio)-3-(unsubstituted, benzamidomethyl or methoxy)-2-(styryl or benzoyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 47, no. 11 (1994): 1989. http://dx.doi.org/10.1071/ch9941989.

Full text

Abstract:

Some 6-( chloro, alkylthio, phenylthio, benzylthio or pyridinylmethylthio )-3-( unsubstituted , benzamidomethyl or methoxy )-2-styrylimidazo[1,2-b] pyridazines and 6-chloro-3-( unsubstituted and benzamidomethyl )-2-benzoylimidazo[1,2-b] pyridazines have been prepared and tested for their ability to displace [3H]diazepam from rat brain plasma membranes. The structures of 6-chloro-2-benzoyl[and 6-fluoro-2-(4′-tolyl)] imidazo [1,2-b] pyridazine have been confirmed by X-ray analyses. The reactions of 6-methylthio(and 6-phenylthio)pyridazin-3-amines with 3-bromo-1-phenylpropane-1,2-dione also have been investigated. The 6-substituted 3-unsubstituted 2-styryl(and benzoyl ) imidazo [1,2-b] pyridazines did not bind strongly to rat brain benzodiazepine receptors; nor did the 3-benzamidomethyl or 3-methoxy derivatives (cf. the 2-phenyl analogues). However, 3-benzamidomethyl-6-(pyridin-3-ylmethylthio)-2-styrylimidazo[1,2-b] pyridazine was an exception with IC50 68 nM.

APA, Harvard, Vancouver, ISO, and other styles

4

Barlin, Gordon B., Les P. Davies, and Peter W. Harrison. "Imidazo[1,2-b]pyridazines. XXI. Syntheses of some 3-Acylaminomethyl-6-(chloro and iodo)- 2-(substituted phenyl)-imidazo[1,2-b]pyridazines and -imidazo[1,2-a]pyridines and their Interaction with Central and Mitochondrial Benzodiazepine." Australian Journal of Chemistry 50, no. 1 (1997): 61. http://dx.doi.org/10.1071/c96130.

Full text

Abstract:

A series of 3-acylaminomethyl-6-(chloro, iodo and methyl)-2-(phenyl, 4′-t-butylphenyl, 4′-cyclohexyl- phenyl, biphenyl-4′-yl, 4′-chlorophenyl and 4′-iodophenyl)imidazo[1,2-b]pyridazines and imidazo[1,2- a]pyridines has been prepared and examined for interaction with central and mitochondrial (peripheral- type) benzodiazepine receptors. The imidazo[1,2-b]pyridazines were generally more selective for the mitochondrial receptors than the corresponding imidazo[1,2-a]pyridines. Of these compounds, 3- acetamidomethyl-2-(biphenyl-4′-yl)-6-chloroimidazo[1,2-b]pyridazine (9) proved to be the most selective in studies of the displacement of [3H]diazepam from peripheral-type and central benzodiazepine receptors (IC50 2·8 nM and 0% displacement at 1000 nM, respectively).

APA, Harvard, Vancouver, ISO, and other styles

5

Barlin, Gordon B., Les P. Davies, Stephen J. Ireland, and Maria M. L. Ngu-Schwemlein. "Imidazo[1,2-b]pyridazines. XXII. Syntheses of Some 2-Aryl-3-methoxy-6-(pyridinylmethylthio and pyridinylmethylamino)imidazo[1,2-b]pyridazines and Their Interaction with Central and Mitochondrial (Peripheral-Type) Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 2 (1997): 91. http://dx.doi.org/10.1071/c96136.

Full text

Abstract:

2-Aryl-3-methoxy-6-(pyridinylmethylthio and pyridinylmethylamino)imidazo[1,2-b]pyridazines have been prepared and examined as ligands for benzodiazepine receptors. Most were highly effective in displacing [3H]diazepam from central benzodiazepine receptors present in rat brain membranes but showed little capacity for its displacement from mitochondrial (peripheral-type) benzodiazepine receptors present in rat kidney membranes. For example, 3-methoxy-2-(3′,4′-methylenedioxyphenyl)-6-(pyridin-2′′-ylmethylthio)imidazo[1,2-b]pyridazine had an IC50 value of 1 · 7 nM for central receptors but gave only 39% displacement at 1000 nM for mitochondrial receptors. Of all the compounds described in this series of papers, 3-methoxy-6-(2′-methoxybenzylamino)-2-(3′′,4′′-methylenedioxyphenyl)imidazo[1,2-b]pyridazine was the most active in displacing [3H]diazepam from central receptors (IC50 0·3 nM), and it had a low affinity for mitochondrial receptors (40% displacement of [3H]diazepam at 1000 nM).

APA, Harvard, Vancouver, ISO, and other styles

6

Barlin, GB, LP Davies, B. Glenn, PW Harrison, and SJ Ireland. "Imidazo[1,2-b]pyridazines. XV. Synthesis and Anxiolytic Activity of Some 3-(Benzamidomethyl and fluorobenzamidomethyl)-6-(fluoro, chloro and methylthio)-2-(4-tolyl and 3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 47, no. 4 (1994): 609. http://dx.doi.org/10.1071/ch9940609.

Full text

Abstract:

Syntheses are reported for some 3-( benzamido-and fluorobenzamido -methyl)-6-( fluoro , chloro and methylthio )-2(4-methyl-, 4-t-butyl-, 4-cyclohexyl- and 3,4-methylenedioxy-phenyl) imidazo-[1,2-b] pyridazines from the relevant 3-unsubstituted imidazo [1,2-b] pyridazines and the N-( hydroxymethyl ) benzamides. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(3- or 4-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl)-6-methylthioimidazo[1,2-b]- pyridazine bound most strongly, with IC50 2nM; but in behavioural tests in rats the most active compounds were 6-chloro(and methylthio )-3-(2-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl) imidazo [1,2-b] pyridazines which showed a significant anxiolytic activity at 2.5 mg/kg.

APA, Harvard, Vancouver, ISO, and other styles

7

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-b]Pyridazines. VIII. Syntheses and Central Nervous System Activities of Some 6-Benzylamino (and methoxybenzylamino)-3-methoxy-2-phenyl(Substituted phenyl or pyridinyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 42, no. 10 (1989): 1759. http://dx.doi.org/10.1071/ch9891759.

Full text

Abstract:

Syntheses and IC50 values for the displacement of 3H-diazepam from rat brain plasma membrane are reported for a series of 6-benzylamino(and methoxybenzylamino )-3-methoxy-2-phenyl(substituted phenyl and pyridinyl )imidazo[l,2-b]pyridazines (and their 6-anilino and 6-phenethylamino analogues). The results are compared with those reported previously (by us) for the 6-chloro, 6-phenoxy, 6-benzylthio, and 6-benzyloxy compounds. In the imidazo[l,2-b]pyridazine ring system, 6-(o- and m- methoxybenzylamino ) groups were found to be beneficial to binding activity; eight compounds have been prepared with IC50 values less than 2 nM (cf. 3H-diazepam with IC50 of 4.2 nM ).2-(p-Aminopheny1)-3-methoxy- 6-(m- methoxybenzylamino )imidazo[1,2-b]pyridazine exhibited the highest activity with IC50 1.0 nM.

APA, Harvard, Vancouver, ISO, and other styles

8

Delaye, Pierre-Olivier, Mélanie Pénichon, Leslie Boudesocque-Delaye, Cécile Enguehard-Gueiffier, and Alain Gueiffier. "Natural Deep Eutectic Solvents as Sustainable Solvents for Suzuki–Miyaura Cross-Coupling Reactions Applied to Imidazo-Fused Heterocycles." SynOpen 02, no. 04 (October 2018): 0306–11. http://dx.doi.org/10.1055/s-0037-1610400.

Full text

Abstract:

Herein, we present the first Suzuki–Miyaura cross-coupling in a sustainable natural deep eutectic solvent (NaDES) applied to biologically relevant imidazo-fused scaffolds imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine. The choline chloride/glycerol (1:2, mol/mol) NaDES allowed the functionalisation of diverse positions on the heterocycles with various boronic acids, by using 2.5 mol% of readily available Pd(OAc)2. Notably, the catalytic system proceeds without any ligands or additives, without protection from the atmosphere.

APA, Harvard, Vancouver, ISO, and other styles

9

Sharma, Rakesh Kumar, Manisha Singh, Khagendra Ghimeray, Pinky Juneja, Gagan Dev, Sridhar Pulavarthi, Sabbasani Rajasekhara Reddy, and Ravi Shankar Akundi. "Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32." Molecules 26, no. 17 (September 1, 2021): 5319. http://dx.doi.org/10.3390/molecules26175319.

Full text

Abstract:

Imidazo[1,2-b]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity. Two of these substituted 3-nitro-6-amino-imidazo[1,2-b]pyridazine compounds (5c and 5h) showed potent acetylcholinesterase (AChE) inhibitory activity (IC50 40–50 nM), which we have previously reported. In this study, we wanted to test the biological efficacy of these compounds. Cytotoxicity assays showed that compound 5h mediated greater cell death with over 43% of cells dead at 100 μM and activation of caspase 3-mediated apoptosis. On the other hand, compound 5c mediated a dose-dependent decrease in cell proliferation. Both compounds showed cell cycle arrest in the G0/G1 phase and reduced cellular ATP levels leading to activation of adenosine monophosphate-activated protein kinase (AMPK) and enhanced mitochondrial oxidative stress. It has to be noted that all these effects were observed at doses beyond 10 μM, 200-fold above the IC50 for AChE inhibition. Both compounds also inhibited bacterial lipopolysaccharide-mediated cyclooxygenase-2 and nitric oxide release in primary rat microglial cells. These results suggested that the substituted imidazo (1,2-b) pyridazine compounds, which have potent AChE inhibitory activity, were also capable of antiproliferative, anti-migratory, and anti-inflammatory effects at higher doses.

APA, Harvard, Vancouver, ISO, and other styles

10

Abd El-Salam, Nasser M., Mohamed S. Mostafa, Gamal A. Ahmed, and Othman Y. Alothman. "Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)-thione." Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/890617.

Full text

Abstract:

Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized starting from 6-chloropyridazin3-(2H)-thione. Some disulfide and sulfide derivatives were also prepared. The antimicrobial activity of the synthesized compounds was tested. Some of these compounds possess a highly response against gram-positive and gram-negative bacteria as well as fungi.

APA, Harvard, Vancouver, ISO, and other styles

11

Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XIV. Syntheses and Central Nervous System Activities of Some 6-(Methoxy-, dimethoxy-, methylenedioxy-, chloro- and fluoro-)-3-alkoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 46, no. 3 (1993): 353. http://dx.doi.org/10.1071/ch9930353.

Full text

Abstract:

Syntheses are reported for 28 new 3-alkoxy-6-(3′-methoxy-,3′,4′-dimethoxy, 3′,4′-methylene-dioxy-, 2′- and 4′-chloro- and 4′-fluoro-benzylamino)-2-phenyl(and substituted phenyl) imidazo -[1,2-b] pyridazines from the corresponding 6-substituted pyridazin-3-amine 2-oxides with α- bromoacetophenones, followed by alkylation of the intermediate 3-hydroxyimidazo[1,2-b] pyridazines. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(2′-ethoxyethoxy)-6(3′-methoxybenzylamino)-2-phenyl- and 6(3′,4′-methylenedioxybenzylamino )-2-(3″,4″-methylenedioxyphenyl)-3-methoxy-imidazo[1,2-b] pyridazine bound most strongly, with IC50 values of 1nM.

APA, Harvard, Vancouver, ISO, and other styles

12

Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XIII. Syntheses and Central Nervous System Activities of Some 2-Benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-Butyl and cyclohexyl)-3-methoxy(acylaminomethyl and dimethylaminomethyl)-6-(variously substituted)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 8 (1992): 1281. http://dx.doi.org/10.1071/ch9921281.

Full text

Abstract:

6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethy1)-2-benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)imidazo[1,2-b] pyridazines have been prepared and examined for activity in the central nervous system. Of these, 2-benzyl-3-methoxy-6-(3'-methoxybenzylamino) imidazo[1,2-b]pyridazine (IC50 88nM) bound most strongly to rat brain membrane. In general, the order of activity for groups at the 2-position was Ph > PhCH2 > PhCH2CH2 > C6H4Ph-p, 6'-methylnaphthalen-2'-yl, c-C6H11 or But.

APA, Harvard, Vancouver, ISO, and other styles

13

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-B]Pyridazines. III. Syntheses and Central Nervous-System Activities of Some 6-Chloro-3-methoxy (and ethoxy)-2-aryl (and heteroaryl)imidazo[1,2-B]pyridazines." Australian Journal of Chemistry 41, no. 8 (1988): 1149. http://dx.doi.org/10.1071/ch9881149.

Full text

Abstract:

The synthesis of a series of 6-chloro-3-methoxy(and ethoxy )-2- phenyl[and (variously substituted phenyl), thienyl, and naphthalenyl ] imidazo [1,2-b] pyridazines and a 6-fluoro analogue are reported. These compounds were tested for their ability to displace [3H]diazepam bound to washed rat brain plasma membranes. Under standard assay conditions (see Experimental) and in the presence of 100 μM γ- aminobutyric acid, 6-chloro-3-methoxy-2-(p-tolyl ) imidazo [1,2- b] pyridazine was the most active compound with an IC50 value of 148 nM (cf. diazepam, with IC50 of 4.2 nM).

APA, Harvard, Vancouver, ISO, and other styles

14

Wang, Ling-Ling, Ming-Liang Ma, Xiao-Hong Shen, and Shi-Guo Zhao. "6-Chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine." Acta Crystallographica Section E Structure Reports Online 61, no. 12 (November 10, 2005): o4030—o4031. http://dx.doi.org/10.1107/s1600536805035920.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

M., Sumakanth, V. Malla Reddy, V. S. H. Krishnan, and B. S. Sastry. "Synthesis of Some New Imidazo[1,2-b] Pyridazines." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (May 31, 2009): 471–76. http://dx.doi.org/10.37285/ijpsn.2009.2.1.14.

Full text

Abstract:

Several 2,6-diaryl-imidazo[1,2-b]pyridazines (5 & 7) were prepared from 3-amino-6-aryl-pyridazines (3) which in turn were obtained from the corresponding 6-aryl-pyridazine-3(2H)-ones(1) via., 6-aryl-pyridazin-3(2H)-thiones (2) as intermediates, by a reaction with an appropriate a-halocarbonyl compounds (4) or a-haloacyl carbamates (6) in a suitable solvent at reflux temperature. The resulted products were characterized by their physical, analytical and spectral data.

APA, Harvard, Vancouver, ISO, and other styles

16

Barlin, GB, LP Davies, and SJ Ireland. "Imidazo[1,2-b]Pyridazines. XIX. Syntheses and Central Nervous System Activities of Some 6-Arylthio(aryloxy and alkylthio)-3-(acetamidomethyl, benzamidomethyl, methoxy and unsubstituted)-2-arylimidazo[1,2-b]pyridazines." Australian Journal of Chemistry 49, no. 4 (1996): 443. http://dx.doi.org/10.1071/ch9960443.

Full text

Abstract:

Some 6-arylthio( aryloxy and alkylthio )-3-( acetamidomethyl , benzamidomethyl, methoxy and unsubstituted )-2-arylimidazo[1,2-b] pyridazines have been prepared and examined for their ability to displace [3H]diazepam from rat brain membranes. The most active compound was 3-acetamidomethyl-2-(3',4'-methylenedioxyphenyl)-6-phenylthioimidazo[1,2-b] pyridazine with IC50 4.4 nM. The 3-acylaminomethyl-6-(2- and 3-methoxyphenylthio)-2-phenylimidazo[1,2-b] pyridazines proved less active than their 6-phenylthio analogues, and larger substituents at the 2- and 6-positions markedly decreased binding. Significant differences in binding ability have been observed between 3-acylaminomethyl-2-aryl-6-phenylthioimidazo[1,2-b] pyridazines and the corresponding imidazo [1,2-a]pyridines.

APA, Harvard, Vancouver, ISO, and other styles

17

Meegalla, Sanath K., Hui Huang, Carl R. Illig, Daniel J. Parks, Jinsheng Chen, Yu-Kai Lee, Kenneth J. Wilson, et al. "Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors." Bioorganic & Medicinal Chemistry Letters 26, no. 17 (September 2016): 4216–22. http://dx.doi.org/10.1016/j.bmcl.2016.07.054.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XI. Syntheses and Central Nervous System Activities of Some 6-(N-Benzyl-N-methylamino)-3-methoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 4 (1992): 751. http://dx.doi.org/10.1071/ch9920751.

Full text

Abstract:

Syntheses are reported for 196-(N-benzyl-N-methylamino )-3-methoxy-2-phenyl(and substituted phenyl or pyridinyl ) imidazo [1,2-b] pyridazines from 6-(N-benzyl-N-methylamino)pyridazin-3- amine 2-oxide. The ability of each of these compounds to displace [3H]diazepam from rat brain membrane preparations was measured and the IC50 values (or percentage displacements) are reported and discussed. 6-(N-Benzyl-N-methylamino )-3-methoxy-2-phenylimido[1,2-b]pyridine was about half as active as its 6-bemylamino analogue, and the most active compound was 6-(N-benzyl-N-methylamino )-2-(2'-fluorophenyl)-3-methoxyimido[1,2-b] pyridazine with IC50 9.8 nM.

APA, Harvard, Vancouver, ISO, and other styles

19

Barlin, GB, LP Davies, RA Davis, and PW Harrison. "Imidazo[1,2-b]pyridazines. XVII. Synthesis and Central Nervous System Activity of Some 6-(Alkylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines Containing Methoxy, Methylenedioxy and Methyl Substituents." Australian Journal of Chemistry 47, no. 11 (1994): 2001. http://dx.doi.org/10.1071/ch9942001.

Full text

Abstract:

Syntheses are reported for 6-( methylthio, ethylthio, propylthio, substituted benzylthio and chloro )-3-( methoxy, unsubstituted and benzamidomethyl )-2-arylimidazo[1,2-b] pyridazines containing methoxy, methylenedioxy and methyl groups attached to phenyl substituents . In tests of the ability of these compounds to displace [3H]diazepam from rat brain membranes, 3-methoxy-6-(3′,4′-methylenedioxybenzylthio)-2- (3′,4′-methylenedioxyphenyl) imidazo [1,2-b] pyridazine (IC50 1 nM) bound most strongly; methylenedioxy groups were beneficial to activity whereas polymethoxy or dimethyl substituents were generally detrimental.

APA, Harvard, Vancouver, ISO, and other styles

20

Barlin, GB, LP Davies, SJ Ireland, MML Ngu, and JK Zhang. "Imidazo[1,2-b]pyridazines. X. Syntheses and Central Nervous System Activities of Some 3-(Acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 4 (1992): 731. http://dx.doi.org/10.1071/ch9920731.

Full text

Abstract:

Syntheses of some 3-( acetamido, benzamido , substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6( halogeno, alkylthio, alkoxy, phenylthio, phenoxy , benzylthio or benzyloxy ) imidazo [1,2-b] pyridazines from the 3-unsubstituted analogues are described. The IC50 values (or percentage displacements) are reported and discussed for the displacement of [3H]diazepam from rat brain membrane by each of these compounds. .The 3-benzamidomethyl compounds were generally the most active; of these, 3-benzamidomethyl-2-(3',4'-methylenedioxyphenyl)-6-methylthioimido[1,2-b] pyridazine showed outstanding activity with IC50 2 nM .

APA, Harvard, Vancouver, ISO, and other styles

21

Walsh, Thomas F., Kenneth J. Fitch, Malcolm MacCoss, Raymond S. L. Chang, Salah D. Kivlighn, Victor J. Lotti, Peter K. S. Siegl, Arthur A. Patchett, and William J. Greenlee. "Synthesis of new imidazo[1,2-b]pyridazine isosteres of potent imidazo[4,5-b]pyridine angiotensin II antagonists." Bioorganic & Medicinal Chemistry Letters 4, no. 1 (January 1994): 219–22. http://dx.doi.org/10.1016/s0960-894x(01)81150-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Barlin, GB, LP Davies, PW Harrison, SJ Ireland, and AC Willis. "Imidazo[1,2-b]Pyridazines. XXI. Syntheses of Some 3-Acylaminomethyl-6-(chloro, fluoro, methoxy, methylthio, phenoxy and phenylthio)-2-(phenyl, 4-t-butylphenyl, 4-cyclohexylphenyl, β-naphthyl and styryl)imidazo[1,2-b]pyridazines and Their Interaction With Central and Peripheral-Type Benzodiazepine Receptors." Australian Journal of Chemistry 49, no. 4 (1996): 451. http://dx.doi.org/10.1071/ch9960451.

Full text

Abstract:

Some 3-(aliphatic and aromatic) acylaminomethyl derivatives of 6-( chloro, fluoro, methoxy, methylthio, phenoxy and phenylthio )-2-(phenyl, 4-t-butylphenyl, 4-cyclohexylphenyl, β- naphthyl and styryl ) imidazo [1,2-b] pyridazines have been prepared and tested for binding to central benzodiazepine receptors present in rat brain membrane, and to peripheral-type (mitochondrial) benzodiazepine receptors present in rat kidney membrane. Some of these compounds which contained 2-(4-t-butylphenyl, 4-cyclohexylphenyl and styryl ) substituents bound strongly and selectively to peripheral-type benzodiazepine receptors. For example, 2-(4′-t-butylphenyl)-6-chloro-2-(4″-fluorobenzamidomethyl) imidazo [1,2-b] pyridazine in tests for the displacement of [3H]diazepam from both peripheral-type and central benzodiazepine receptors gave IC50 <1.0 nM and 9% displacement at 1000 nM , respectively. Steric effects appeared to be more restrictive in the interaction of these ligands with central benzodiazepine receptors rather than with peripheral-type benzodiazepine receptors; X-ray structure analyses of two typical compounds are reported.

APA, Harvard, Vancouver, ISO, and other styles

23

WALSH, T. F., K. J. FITCH, M. MACCOSS, R. S. L. CHANG, S. D. KIVLIGHN, V. J. LOTTI, P. K. S. SIEGL, A. A. PATCHETT, and W. J. GREENLEE. "ChemInform Abstract: Synthesis of New Imidazo(1,2-b)pyridazine Isosteres of Potent Imidazo( 4,5-b)pyridine Angiotensin II Antagonists." ChemInform 25, no. 26 (August 19, 2010): no. http://dx.doi.org/10.1002/chin.199426189.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-b]pyridazines. VII. Syntheses and Central Nervous System Activities of Some 3-Alkoxy-6-benzyloxy (and methoxy-benzyloxy)-2-phenyl(substituted phenyl or pyridinyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 42, no. 10 (1989): 1749. http://dx.doi.org/10.1071/ch9891749.

Full text

Abstract:

A series of 15 3-alkoxy-6-benzyloxy( methoxybenzyloxy )-2-phenyl( sbstitted phenyl and pyridinyl )imidazo[l,2-b]pyridazines has been prepared and each compound tested for its ability to displace 3H-diazepam from rat brain plasma membranes. The results have been compared with data previously obtained for other derivatives of this ring system. Compounds containing 6(o- or m- methoxybenzyloxy ) groups were more effective in the displacement of 3H-diazepam than those with the 6-benzyloxy group; and the most active compound was 2-(p- fluorophenyl )-3-methoxy-6-(m- methoxybenzyloxy )imidazo[l,2 b]pyridazine with IC50 1.5 nM.

APA, Harvard, Vancouver, ISO, and other styles

25

Bendjeddou, Lyamin Z., Nadège Loaëc, Benoît Villiers, Eric Prina, Gerald F. Späth, Hervé Galons, Laurent Meijer, and Nassima Oumata. "Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor." European Journal of Medicinal Chemistry 125 (January 2017): 696–709. http://dx.doi.org/10.1016/j.ejmech.2016.09.064.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Fan, Lingling, Zhongfu Luo, Yi Li, Xinyun Liu, Judi Fan, Wei Xue, Lei Tang, and Yong Li. "Synthesis and antifungal activity of imidazo[1,2-b]pyridazine derivatives against phytopathogenic fungi." Bioorganic & Medicinal Chemistry Letters 30, no. 14 (July 2020): 127139. http://dx.doi.org/10.1016/j.bmcl.2020.127139.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Barlin, GB, LP Davies, SJ Ireland, MML Ngu, and JK Zhang. "Imidazo[1,2-b]pyridazines. XII. Syntheses and Central Nervous System Activities of Some Substituted Imidazo[1,2-b]pyridazines and Related Imidazo[1,2-a]pyridines, Imidazo[1,2-a]pyrimidines and Imidazo[1,2-a]pyrazines." Australian Journal of Chemistry 45, no. 5 (1992): 877. http://dx.doi.org/10.1071/ch9920877.

Full text

Abstract:

Syntheses are reported for some 6-chloro(alkoxy,alkylthio and pheny1thio)-3-benzamidomethyl-(acetamidomethyl and methoxy)-2-arylimidazo[1,2-apyridines and some corresponding imidazo- [1,2- b]pyridazines, imidazo[1,2-a[pyrimidines and imidazo[l,2-a]pyrazines. IC50 values (or percentage displacement) are reported and discussed for the displacement of [3H]diazepam from rat brain membrane by each of these compounds. The imidazo[l,2-a[pyridines were generally slightly less potent than the imidazo[l,2- b]pyridazines but considerably more potent than the corresponding imidazo[1,2-a]pyrimidines or imidazo[1,2- a[pyrazines. Substitution of a 2-aryl group by a 2-alkyl group in imidazo[l,2- b]pyridazines led to a significant loss of activity.

APA, Harvard, Vancouver, ISO, and other styles

28

Aziz, Jessy, and Sandrine Piguel. "An Update on Direct C–H Bond Functionalization of Nitrogen-Containing Fused Heterocycles." Synthesis 49, no. 20 (August 25, 2017): 4562–85. http://dx.doi.org/10.1055/s-0036-1590859.

Full text

Abstract:

This report highlights the recent advances in direct C–H bond functionalization of 5,5- and 6,5-fused heterocycles containing at least two nitrogen atoms. Besides C–C bond formation, C–N, C–S, C–P, and C–Si bonds can also be created via a metal-catalyzed process. Some examples, where a C–H functionalization approach was applied for the synthesis of drug candidates, will be presented as well.1 Introduction2 C–H Functionalization Reactions of N-Containing Heterocycles2.1 Imidazo[1,2-a]pyridines2.2 Pyrrolo[1,2-a]pyrazines2.3 Imidazo[1,2-b]pyrazoles2.4 Imidazo[1,2-a]pyrimidines2.5 Imidazo[1,2-a]pyrazines and Imidazo[1,5-a]pyrazines2.6 Imidazo[1,2-b]pyridazines2.7 Imidazo[4,5-b]pyridines and Imidazo[4,5-c]pyridines2.8 Pyrazolo[3,4-b]pyridines2.9 Pyrazolo[1,5-a]pyrimidines2.10 Pyrrolo[2,3-d]pyrimidines and Pyrrolo[3,2-d]pyrimidines2.11 Imidazo[1,2-b][1,2,4]triazines2.12 Imidazo[1,2-b][1,2,4,5]tetrazines3 Outlook4 Conclusion

APA, Harvard, Vancouver, ISO, and other styles

29

Mourad, Alaa E., Dean S. Wise, and Leroy B. Townsend. "Methyl imidazo[1,2-b]pyridazine-2-carbamates and related compounds as potential antifilarial agents." Journal of Heterocyclic Chemistry 29, no. 6 (October 1992): 1583–92. http://dx.doi.org/10.1002/jhet.5570290636.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Mao, Beibei, Shanyun Gao, Yiran Weng, Liangren Zhang, and Lihe Zhang. "Design, synthesis, and biological evaluation of imidazo[1,2- b ]pyridazine derivatives as mTOR inhibitors." European Journal of Medicinal Chemistry 129 (March 2017): 135–50. http://dx.doi.org/10.1016/j.ejmech.2017.02.015.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Darby, Richard A. J., Amanda Unsworth, Stefan Knapp, Ian D. Kerr, and Richard Callaghan. "Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors." Cancer Chemotherapy and Pharmacology 76, no. 4 (September 9, 2015): 853–64. http://dx.doi.org/10.1007/s00280-015-2858-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Renoud-Grappin, M., C. Fossey, G. Fontaine, D. Ladurée, AM Aubertin, and A. Kirn. "Imidazo[1,5-b]Pyridazine-D4T Conjugates: Synthesis and Anti-Human Immunodeficiency Virus Evaluation." Antiviral Chemistry and Chemotherapy 9, no. 3 (June 1998): 205–23. http://dx.doi.org/10.1177/095632029800900302.

Full text

Abstract:

In an attempt to combine the human immunodeficiency virus type 1 (HIV-D-inhibitory capacity of 2′,3 -dideoxy-2,3 -didehydronucleoside analogues [nucleoside reverse transcriptase (RT) inhibitors; NRTI] and non-nucleoside RT inhibitors (NNRTI), we have designed, synthesized and evaluated for their anti-HIV activity several heterodimers of the general formula [d4T]-NH-(CH2)n-NH-[imidazo[1,5–b]pyridazine]. The synthesis of these heterodimers was conducted in three parts. The first part focused on the synthesis of the NRTI. The second part was devoted to the NNRTI and the NNRTI linked to appropriate spacers; [NNRTI]-NH-(CH2)n-NH2. In the third part, the condensation between the NRTI and the [NNRTI]-NH-(CH2)n-NH2 was performed. The in vitro inhibitory activities against HIV-1 of the [d4T]-NH-(CH2)n-NH-[imidazo[1,5–b]pyridazine] heterodimers were found to be comparable to that of d4T (stavudine) in HIV-infected cells. Moreover, the heterodimers were endowed with anti-HlV-2 activity and with anti-nevirapine-resistant HIV-1 activity. None of the heterodimers proved markedly cytotoxic to CEM-SS or MT-4 cells. There was not a clear trend toward antiviral potency on lengthening the methylene spacer in the [d4T]-NH-(CH2)n-NH-[imidazo[1,5–b]pyridazine] heterodimers.

APA, Harvard, Vancouver, ISO, and other styles

33

Galtier, Christophe, Sylvie Mavel, Robert Snoeck, Graciela Andreï, Christophe Pannecouque, Myriam Witvrouw, Jan Balzarini, Erik De Clercq, and Alain Gueiffier. "Synthesis and Antiviral Activities of 3-Aralkyl-Thiomethylimidazo[1,2-b]Pyridazine Derivatives." Antiviral Chemistry and Chemotherapy 14, no. 4 (August 2003): 177–82. http://dx.doi.org/10.1177/095632020301400402.

Full text

Abstract:

The synthesis of novel substituted 3-aralkylth-iomethylimidazo[1,2- b]pyridazines is reported. All of the synthesized compounds are devoid of antiviral activity against the replication of human immunodeficiency virus. However, compounds 6-chloro-8-methyl-3-phenethylthioimidazo[1,2- b]pyridazine and 6-chloro-2-methyl-3-phenethyl-thioimidazo[1,2- b]pyridazine are potent inhibitors of the replication of human cytomegalovirus in vitro, while compounds 6-chloro-2-methyl-3-benzylthiomethylimidazo[1,2- b]pyridazine and 6-chloro-2-methyl-3-phenethyl-thioimidazo[1,2- b]pyridazineare inhibitors of the replication of varicella-zoster virus. The results presented here suggest that compound 10 should be considered as a new lead in the development of antiviral agents.

APA, Harvard, Vancouver, ISO, and other styles

34

Davies, Les P., Gordon B. Bariin, and Michael L. Selley. "New imidazo[1,2-b]pyridazine ligands for peripheral-type benzodiazepine receptors on mitochondria and monocytes." Life Sciences 57, no. 25 (November 1995): PL381—PL386. http://dx.doi.org/10.1016/0024-3205(95)02233-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Chidella, Karunakar, Nareshvarma Seelam, Purna Koteswara Rao Cherukumalli, Jagannadha Reddy N, and Gattu Sridhar. "Design and synthesis of novel 1,2,4-Thiadiazole linked imidazo[1,2-b]pyridazine as anticancer agents." Chemical Data Collections 30 (December 2020): 100554. http://dx.doi.org/10.1016/j.cdc.2020.100554.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Wang, Ling-Ling. "3-p-Tolylimidazo[1,2-b]pyridazine." Acta Crystallographica Section E Structure Reports Online 63, no. 4 (March 14, 2007): o1749—o1750. http://dx.doi.org/10.1107/s1600536807009944.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

DaVies, Les P., Gordon B. Barlin, Stephen J. Ireland, and Maria M. L. Ngu. "Substituted imidazo[1,2-b]pyridazines." Biochemical Pharmacology 44, no. 8 (October 1992): 1555–61. http://dx.doi.org/10.1016/0006-2952(92)90472-u.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Barlin, GB, LP Davies, SJ Ireland, and MML Ngu. "Imidazo[1,2-b]Pyridazines. V. Syntheses and Central Nervous Activities of Some 3-Alkoxy-6-benzylthio(substituted benzylthio and Other phenylalkylthio)-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 42, no. 7 (1989): 1133. http://dx.doi.org/10.1071/ch9891133.

Full text

Abstract:

Syntheses are reported for a number of 3-alkoxy-6-benzylthio(substituted benzylthio and other phenylalkylthio )-2-phenyl(and substituted phenyl)imidazo[l,2-b]pyridazines. These compounds were then examined for their ability to displace 3H-diazepam from rat brain membranes. In preliminary tests, in the presence of 100 �m γ- aminobutyric acid (GABA) and under standard assay conditions (see Experimental), 6-benzylthio-3-methoxy-2-phenylimidazo[l,2- b]pyridazine gave an lC50 value of 25nM (IC50 for unlabelled diazepam is 4.3 nM ); its 6-(m- aminophenyl ), 6-(p- aminophenyl ) and 6-(m- nitrophenyl ) analogues gave values of 15, 9 and 8 nM respectively.

APA, Harvard, Vancouver, ISO, and other styles

39

Farag, Ahmad M., and Kamal M. Dawood. "One-pot synthesis of imidazo[1,2-b]pyrazole, imidazo[1,2-b]-1,2,4-triazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, imidazo[1,2-a]benzimidazole, and 1,2,4-triazolo[4,3-a]benzimidazole derivatives." Heteroatom Chemistry 8, no. 2 (1997): 129–33. http://dx.doi.org/10.1002/(sici)1098-1071(1997)8:2<129::aid-hc4>3.0.co;2-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Stanovnik, Branko, Borut Furlan, Marko Kupper, Lidija Malež, Anton Štimac, Miha Tišler, and Marko Žličar. "The synthesis and transformations of 9H-imidazo[1,2-b]pyrazolo[4,3-d]-pyridazine and 9H-pyrazolo[4,3-d]-s-triazolo[4,3-b]pyridazine derivatives." Journal of Heterocyclic Chemistry 25, no. 2 (March 1988): 393–98. http://dx.doi.org/10.1002/jhet.5570250208.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Liu, Chunjian, James Lin, Ryan Moslin, John S. Tokarski, Jodi Muckelbauer, ChiehYing Chang, Jeffrey Tredup, et al. "Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors." ACS Medicinal Chemistry Letters 10, no. 3 (February 21, 2019): 383–88. http://dx.doi.org/10.1021/acsmedchemlett.9b00035.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

MOURAD, A. E., D. S. WISE, and L. B. TOWNSEND. "ChemInform Abstract: Methyl Imidazo(1,2-b)pyridazine-2-carbamates and Related Compounds as Potential Antifilarial Agents." ChemInform 24, no. 18 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199318228.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

El Akkaoui, Ahmed, Jamal Koubachi, Gérald Guillaumet, and Saïd El Kazzouli. "Synthesis and Functionalization of Imidazo[1,2‐ b ]Pyridazine by Means of Metal‐Catalyzed Cross‐Coupling Reactions." ChemistrySelect 6, no. 34 (September 8, 2021): 8985–9011. http://dx.doi.org/10.1002/slct.202101636.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Matsumoto, Shigemitsu, Naoki Miyamoto, Takaharu Hirayama, Hideyuki Oki, Kengo Okada, Michiko Tawada, Hidehisa Iwata, et al. "Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors." Bioorganic & Medicinal Chemistry 21, no. 24 (December 2013): 7686–98. http://dx.doi.org/10.1016/j.bmc.2013.10.028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

N. Al-Mohammed, Nassir, Yatimah Alias, Zanariah Abdullah, and Hamid Khaledi. "Imidazo[1,2-b]isoquinoline-5,10-dione." Acta Crystallographica Section E Structure Reports Online 67, no. 7 (June 18, 2011): o1666. http://dx.doi.org/10.1107/s1600536811022082.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Kaieda, Akira, Masashi Takahashi, Takafumi Takai, Masayuki Goto, Takahiro Miyazaki, Yuri Hori, Satoko Unno, et al. "Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors." Bioorganic & Medicinal Chemistry 26, no. 3 (February 2018): 647–60. http://dx.doi.org/10.1016/j.bmc.2017.12.031.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

BARLIN, G. B., L. P. DAVIES, S. J. IRELAND, M. M. L. NGU, and J. ZHANG. "ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 12. Syntheses and Central Nervous System Activities of Some Substituted Imidazo(1,2-b)pyridazines and Related Imidazo(1,2-a)pyridines, Imidazo(1,2-a)pyrimidines and Imidazo( 1,2-a)pyrazines." ChemInform 23, no. 34 (August 21, 2010): no. http://dx.doi.org/10.1002/chin.199234175.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Barlin, GB, LP Davies, and PW Harrison. "Imidazo[1,2-b]Pyridazines. XVIII. Syntheses and Central Nervous System Activities of Some 6-, 7- and 8-(Chloro and methoxy)imidazo[1,2-a]pyridine Analogs." Australian Journal of Chemistry 48, no. 5 (1995): 1031. http://dx.doi.org/10.1071/ch9951031.

Full text

Abstract:

Syntheses are reported for some 2-aryl-3-(benzamidomethyl and methoxy)-6(7 and 8)-chloro- and 6(and 8)-methoxy-imidazo[1,2-a]pyridines. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, those with 6-chloro and 6-methoxy groups bound most strongly, and relatively small differences only were observed between corresponding imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines.

APA, Harvard, Vancouver, ISO, and other styles

49

Barlin, GB, LP Davies, and MML Ngu. "Imidazo[1,2-b]pyridazines. IV. Syntheses and Central Nervous System Activities of Some 3-Methoxy-6-phenoxy(Substituted Phenoxy and Naphthyloxy)-2-phenylimidazo[1,2-b]pyridazines." Australian Journal of Chemistry 41, no. 11 (1988): 1735. http://dx.doi.org/10.1071/ch9881735.

Full text

Abstract:

Syntheses are reported for some 3-methoxy-6-phenoxy(substituted phenoxy and naphthyloxy )-2-phenylimidazo[1,2-b] pyridazines; they were made in order to study their possible pharmacological activity in the mammalian central and peripheral nervous system. In initial biological screens to detect compounds with potential activity at receptors for the benzodiazepine class of drugs, the most active compounds were 3-methoxy-6-(2′-methylthiophenoxy)- and 6-(2′-dimethylaminophenoxy )-3-methoxy-2-phenylimidazo[1,2-b] pyridazine. Their respective IC50 values for displacement of 3H-diazepam (IC50 for unlabelled diazepam, 4.2 nM ) from rat brain plasma membranes (measured in the presence of 100 μM GABA) were 112 and 149 nM.

APA, Harvard, Vancouver, ISO, and other styles

50

LURASCHI, E., F. ARENA, A. SACCHI, S. LANERI, and E. ABIGNENTE. "ChemInform Abstract: Synthesis and Structure-Activity Relationship of a Series of Analgesic Imidazo(1,2-b)pyridazine Acidic Derivatives." ChemInform 28, no. 14 (August 4, 2010): no. http://dx.doi.org/10.1002/chin.199714270.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!