Journal articles: 'IMI 318'

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Ezugwu, E. O., K. A. Olajire, and Z. M. Wang. "Wear evaluation of a self-propelled rotary tool when machining titanium alloy IMI 318." Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture 216, no. 6 (June 1, 2002): 891–97. http://dx.doi.org/10.1243/095440502320193012.

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This paper presents results of a self-propelled rotary tool (SPRT) tipped with round uncoated carbide (WC-Co) inserts in the finish turning of titanium alloy IMI 318. SPRT inserts exhibited superior wear resistance to conventional round and rhomboid-shaped carbides as well as to the rhomboid-shaped physical vapour deposition (PVD) TiN-coated carbide inserts owing to the distribution of the cutting energy along the entire tool edge. The SPRT-tipped inserts suppressed thermally related wear mechanisms at higher speeds beyond the capability of conventional tools. Chipping was the dominant failure mode of the SPRT inserts, resulting from cyclically fluctuating thermal and mechanical shocks induced by the continuous shifting of the cutting edge during machining. A fitted exponential wear model revealed that about 97 per cent of the average flank wear rate of SPRT inserts can be attributed to the joint effect of speed, feed and inclination angle, ε. Tool performance was improved by increasing the inclination angle ε which resulted in a lower machining temperature on account of a higher rotary speed and a lower relative cutting speed during machining. Lower component forces were recorded with SPRT inserts because of the reduced amount of work done in chip formation and lower friction at the rake face.

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Raja, Shahzad G., Umberto Benedetto, Eman Alkizwini, Sapna Gupta, and Mohamed Amrani. "Propensity Score Adjusted Comparison of MIDCAB versus Full Sternotomy Left Anterior Descending Artery Revascularization." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 10, no. 3 (May 2015): 174–78. http://dx.doi.org/10.1097/imi.0000000000000162.

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Objective Minimally invasive direct coronary artery bypass (MIDCAB) has been proposed as an attractive alternative to full sternotomy (FS) revascularization in isolated left anterior descending (LAD) artery disease not suitable for percutaneous coronary intervention. However, surgeons are still reluctant to perform MIDCAB owing to concerns about early and late outcomes. We aimed to compare short- and long-term outcomes after MIDCAB versus FS revascularization. Methods Prospectively collected data from institutional database were reviewed. Data for late mortality were obtained from the General Register Office. MIDCAB was performed in 318 patients, whereas 159 had FS, according to the surgeon's preference, among 477 patients with isolated LAD disease. Inverse propensity score weighting was used to estimate treatment effects on short- and long-term outcomes. Results In the propensity score-adjusted analysis, FS revascularization versus MIDCAB was associated increased rate of surgical site infection [4 (2.8%) versus 1 (0.7%); P = 0.04]. The 2 groups did not significantly differ with regard to other complications including operative mortality. Mean length of hospital stay was similar for the 2 groups. After a mean follow-up time of 6.2 years (interquartile range, 3.5–9.7 years), compared to MIDCAB, FS was not associated with an improved late survival (β coef, −1.42; standard error, 1.65; P = 0.39) or risk reduction for repeat revascularization (β coef, 1.22; standard error, 1.41; P = 0.15). Conclusions MIDCAB was associated with a trend toward better short-term outcomes and excellent long-term results comparable to FS revascularization. According to these findings, surgeons should not be reluctant to perform MIDCAB in isolated LAD disease.

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Dearnley, P. A., and A. N. Grearson. "Evaluation of principal wear mechanisms of cemented carbides and ceramics used for machining titanium alloy IMI 318." Materials Science and Technology 2, no. 1 (January 1986): 47–58. http://dx.doi.org/10.1179/mst.1986.2.1.47.

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REY DE CASTRO MUJICA, Jorge, Jimy ALVAREZ MAYORGA, and Angelo GAFFO LLONTOP. "Síntomas relacionados a trastornos del sueño en supuestos sanos que asisten a un centro de Atención Primaria de Salud." Revista Medica Herediana 16, no. 1 (December 19, 2012): 31. http://dx.doi.org/10.20453/rmh.v16i1.861.

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Objetivo: Evaluar los síntomas relacionados a trastornos del sueño en una población supuestamente sana. Material y Métodos: El estudio fue transversal y descriptivo en adultos supuestos sanos que asistieron a un centro de atención primaria de salud. Se confeccionó una encuesta auto administrada y validada por nosotros. La muestra final de 590 encuestados que corresponde al 28% de la población general de 17 ó más años que vive en el área de influencia. Resultados: Edad promedio fue 32,21+10,62 [16-74] años, 318 (54%) hombres e IMC promedio 25,25+3,75 [16,5-39,8] Kg/m2. Afirmaron presentar ronquido 27% (84/315) de los hombres y 18% (50/269) de mujeres. Refirieron pausas respiratorias durante el sueño 11 % (37/313) de los hombres y 16% (43/264) de mujeres. Reconocieron somnolencia diurna 30% (96/316) de los hombres y 31% (84/271) de las mujeres. Hubo insomnio de conciliación en 61% (194/318) de los hombres y 60% (162/269) de mujeres. Para el caso del insomnio de mantenimiento las frecuencias fueron 41% (126/307) y 46% (119/258) respectivamente. Refirieron despertarse más temprano de lo deseado 59% (189/318) de los hombres y 55% (147/266) de mujeres. Síntomas sugestivos de síndrome de piernas inquietas en 36% (111/307) de los hombres y 32% (82/255) mujeres. Refirieron síntomas relacionados a mioclonus nocturno 24% (77/315) hombres y 23% (62/268) mujeres. Según los encuestados, 33% (196) consideró que tenía algún problema para dormir. Sólo el 16 % (32/196) consultó al médico por dicha razón. Conclusiones: Los resultados de la encuesta muestran la elevada frecuencia de los síntomas asociados a diversos trastornos de sueño así como los cambios observados de acuerdo al género y la edad. La escasa importancia que los médicos y pacientes conceden al tema, justifican la implementación de intervenciones educativas en ambos casos.

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Kumar, Anita, Sanjai Kumar, Thong P. Le, Scott Southwood, John Sidney, Joe Cohen, Alessandro Sette, and Stephen L. Hoffman. "HLA-A*01-Restricted Cytotoxic T-Lymphocyte Epitope from the Plasmodium falciparum Circumsporozoite Protein." Infection and Immunity 69, no. 4 (April 1, 2001): 2766–71. http://dx.doi.org/10.1128/iai.69.4.2766-2771.2001.

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ABSTRACT Here, we report the identification of a novel CD8+cytotoxic T-lymphocyte epitope on the Plasmodium falciparumcircumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians.

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Ciccarese, Chiara, Roberto Iacovelli, Emilio Bria, Giovanni Schinzari, Ernesto Rossi, Serena Astore, Maria Antonella Cannella, et al. "Efficacy of VEGFR-TKI plus immune checkpoint inhibitor (ICI) in metastatic renal cell carcinoma (mRCC) patients with favorable IMDC prognosis." Journal of Clinical Oncology 39, no. 6_suppl (February 20, 2021): 318. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.318.

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318 Background: Combinations of a PD-1/PD-L1 immune checkpoint inhibitor (ICI) with a VEGFR-TKI as front-line/treatment-naïve therapy significantly improve the outcome of metastatic renal cell carcinoma (mRCC) patients. The benefit of these combinations is well evident in IMDC intermediate- and poor-risk population, while it is unclear in the subgroup of mRCC patients with favorable prognosis. We performed a meta-analysis with the aim to evaluate whether the addition of ICIs to VEGFR-TKIs is able to improve the outcome compared to VEGFR-TKIs alone in mRCC patients with favorable IMDC prognosis. Methods: This meta-analysis searched MEDLINE/PubMed, the Cochrane Library and ASCO Meeting abstracts for phase II or III randomized clinical trials (RCTs) testing the combination of VEGFR-TKI+ICI in mRCC. Data extraction was conducted according to the PRISMA statement. The hazard ratios (HRs) for PFS and OS with the relative 95% CIs were extracted from each study. Summary HRs was calculated using random- or fixed-effects models, depending on the heterogeneity of the included studies. Results: Three RCTs were selected for the final analysis, with a total of 605 patients (306 treated with VEGFR-TKI+ICI combinations and 299 who received sunitinib in the control arms). The combination of VEGFR-TKI+ICI improved PFS compared to sunitinib, with a 30% reduction of the risk of progression (fixed-effect, HR=0.70; p = 0.003). However, VEGFR-TKI+ICI combinations did not significantly prolong OS (fixed-effect; HR = 0.94; 95% CI 0.62–1.43; p = 0.77). Conclusions: Our analysis demonstrates a PFS benefit without an OS advantage for VEGFR-TKI+ICI combinations as first-line therapy for mRCC patients with favourable prognosis according to IMDC. Longer follow-up is required to definitely confirm the best therapy for treatment-naïve mRCC patients with favorable prognosis. [Table: see text]

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WATANABE, Takashi, Hideo TANIGUCHI, Ken-ichi HIRAKAWA, and Masaharu KANEKO. "318 Cavitation Flow due to a Cock Valve." Proceedings of Conference of Tohoku Branch 2001 (2001): 101–2. http://dx.doi.org/10.1299/jsmeth.2001.101.

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Mandl, Christian W., Steven L. Allison, Heidemarie Holzmann, Tamara Meixner, and Franz X. Heinz. "Attenuation of Tick-Borne Encephalitis Virus by Structure-Based Site-Specific Mutagenesis of a Putative Flavivirus Receptor Binding Site." Journal of Virology 74, no. 20 (October 15, 2000): 9601–9. http://dx.doi.org/10.1128/jvi.74.20.9601-9609.2000.

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ABSTRACT The impact of a specific region of the envelope protein E of tick-borne encephalitis (TBE) virus on the biology of this virus was investigated by a site-directed mutagenesis approach. The four amino acid residues that were analyzed in detail (E308 to E311) are located on the upper-lateral surface of domain III according to the X-ray structure of the TBE virus protein E and are part of an area that is considered to be a potential receptor binding determinant of flaviviruses. Mutants containing single amino acid substitutions, as well as combinations of mutations, were constructed and analyzed for their virulence in mice, growth properties in cultured cells, and genetic stability. The most significant attenuation in mice was achieved by mutagenesis of threonine 310. Combining this mutation with deletion mutations in the 3′-noncoding region yielded mutants that were highly attenuated. The biological effects of mutation Thr 310 to Lys, however, could be reversed to a large degree by a mutation at a neighboring position (Lys 311 to Glu) that arose spontaneously during infection of a mouse. Mutagenesis of the other positions provided evidence for the functional importance of residue 308 (Asp) and its charge interaction with residue 311 (Lys), whereas residue 309 could be altered or even deleted without any notable consequences. Deletion of residue 309 was accompanied by a spontaneous second-site mutation (Phe to Tyr) at position 332, which in the three-dimensional structure of protein E is spatially close to residue 309. The information obtained in this study is relevant for the development of specific attenuated flavivirus strains that may serve as future live vaccines.

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Du, Benni, and Weichao Zhang. "Theoretical Insight into the Reaction Mechanism and Kinetics for the Criegee Intermediate of anti-PhCHOO with SO2." Molecules 25, no. 13 (July 3, 2020): 3041. http://dx.doi.org/10.3390/molecules25133041.

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In this study, the density functional theory (DFT) and CCSD(T) method have been performed to gain insight into the possible products and detailed reaction mechanism of the Criegee intermediate (CI) of anti-PhCHOO with SO2 for the first time. The potential energy surfaces (PESs) have been depicted at the UCCSD(T)/6-311++G(d,p)//UB3LYP/6-311++G(d,p) levels of theory with ZPE correction. Two different five-membered ring adducts, viz., endo PhCHOOS(O)O (IM1) and exo PhCHOOS(O)O (IM2) have been found in the entrance of reaction channels. Both direct and indirect reaction pathways from IM1 and IM2 have been considered for the title reaction. Our calculations show that the formation of PhCHO+SO3 (P1) via indirect reaction pathways from IM1 is predominant in all the pathways, and the production of P1 via direct dissociation pathway of IM1 and indirect reaction pathways of IM2 cannot be neglected. Moreover, PhCOOH+SO2 (P2) initiated from IM2 is identified as the minor product. According to the kinetic calculation, the total rate constant for the anti-PhCHOO+SO2 reaction is estimated to be 6.98 × 10−10 cm3·molecule−1·s−1 at 298 K.

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Hasegawa, Hiroshi, Yoshiki Sohrin, Masakazu Matsui, Noriko Takeda, and Kazumasa Ueda. "Chemical speciation of inorganic and methylarsenic(III) compounds in aqueous solutions." Applied Organometallic Chemistry 16, no. 8 (2002): 446–50. http://dx.doi.org/10.1002/aoc.318.

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Ward, Brian M., and Bernard Moss. "Golgi Network Targeting and Plasma Membrane Internalization Signals in Vaccinia Virus B5R Envelope Protein." Journal of Virology 74, no. 8 (April 15, 2000): 3771–80. http://dx.doi.org/10.1128/jvi.74.8.3771-3780.2000.

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ABSTRACT The vaccinia virus B5R type I integral membrane protein accumulates in the Golgi network, from where it becomes incorporated into the envelope of extracellular virions. Our objective was to determine the domains of B5R responsible for Golgi membrane targeting in the absence of other viral components. Fusion of an enhanced green fluorescent protein to the C terminus of B5R allowed imaging of the chimeric protein without altering intracellular trafficking and Golgi network localization in transfected cells. Deletion or swapping of B5R domains with corresponding regions of the vesicular stomatitis virus G protein, which is targeted to the plasma membrane, indicated that (i) the N-terminal extracellular domain of B5R had no specific role in Golgi apparatus localization, (ii) the transmembrane domain of B5R was sufficient for exiting the endoplasmic reticulum, and (iii) removal of the cytoplasmic tail impaired Golgi network localization and increased the accumulation of B5R in the plasma membrane. Further experiments demonstrated that the cytoplasmic tail mediated internalization of B5R from the plasma membrane, suggesting a retrieval mechanism. Mutagenesis revealed residues required for Golgi membrane localization and efficient plasma membrane retrieval of the B5R protein: a tyrosine at residue 310 and two adjacent leucines at residues 315 and 316.

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OKA, Yudai, Koki HAMAGUCHI, Tetsuya KINUGASA, Kenya KUWAGI, and Koji YOSHIDA. "318 On repeatability of sand particle movement under a wheel." Proceedings of Conference of Chugoku-Shikoku Branch 2016.54 (2016): _318–1_—_318–2_. http://dx.doi.org/10.1299/jsmecs.2016.54._318-1_.

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Safarmamadov, Safarmamad M., Davron A. Muborakkadamov, and Kimyo S. Mabatkadamova. "COMPLEXATION OF GOLD (III) WITH 1-FURFURYLIDENE AMINO-1,3,4-TRIAZOLE AT 288 – 318 K." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 5 (June 23, 2017): 37. http://dx.doi.org/10.6060/tcct.2017605.5439.

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The potentiometric titration method was used to determine the ionization constant of 1-furfurylideneamino-1,3,4-triazole (pKk = 11.83 log.). The dominating region of 1-furfurylideneamino-1,3,4-triazoles (FF) was identified in a wide pH range. It was shown that 1-furfurylideneamino-1,3,4-triazole ion (HL+) predominates in the pH range up to 0.5-2.0. At pH of 5.0 to 10.5, the neutral molecule (L) predominates, and at pH>13.0 1-furfurylideneamino-1,3,4-triazolate ion (L-) predominates in a solution. To determine the number of a particles formed during the interaction of Au (III) with FF from the potentiometric titration data the dependence of ΔE on -lg [FF] was used for 1-furfurylideneamino-1,3,4-triazole gold (III) complexes at 288-318 K. The slope of the curves of the ΔE-lg [FF] with the excess of 1-furfurylideneamino-1,3,4-triazole at temperatures of 288, 298 and 308 K is 0.059, 0.060 and 0.061 V/mol/l-1, which corresponds to the sequential addition of three molecules of 1-furfurylideneamino-1,3,4-triazole to gold (III). At the temperature of 318 K it is not possible to find the slope angle corresponding to the tris complex due to a quick change in the potential with an excess of FF in a solution. General stability constants of 1-furfuryldenoamino-1,3,4-triazole complexes of Au (III) according to potentiometric titration data was determined by the Friedman method and non-linear least squares method. It was shown that as the temperature increases, the general stability constants of gold (III) complexes are reduced. It was shown that the introduction of substituents into the 1,2,4-triazole molecule affects both the number of particles formed in a solution and the stability of the complexes. Thus, in the system Au (III) -1,2,4-triazole-H2O at 298 K four complex particles are formed, and in the Au (III) system, 1-furfurylideneamino-1,3,4-triazole-H2O only three are formed. The general stability constants of 1,2,4-triazole complexes equal to lgβ1 = 6.56, lgβ2 = 11.13, lgβ3 = 14.94 and lg4 = 18.78 log units, and for 1-furfurylideneamino-1,3,4-triazole complexes Igβ1 = 5.92, lgβ2 = 10.14, lgβ3 = 13.80 log units. The thermodynamic functions of complexe formation were calculated by the temperature coefficient method. It was shown that all complex particles are enthalpy-stabilized. The greatest increase in the exothermicity of the reactions is observed when a complex of three organic-ligand molecules is formed. The value of ΔS at all steps of complexation is negative, which is most likely due to the decrease in the number of particles in a system under study. The spontaneous reaction of complexation is determined by the enthalpy factorFor citation:Safarmamadov S.M., Muborakkadamov D.A., Mabatkadamova K.S. Complexation of gold (III) with 1-furfurylidene amino-1,3,4-triazole at 288 – 318 K. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 5. P. 37-43.

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Govier, Fred E., Neila Smith, and Takeshi Uchida. "Efficacy and Safety of 10 mg Solifenacin Succinate in Patients with Overactive Bladder Syndrome: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Pivotal Trial." Clinical Medicine Insights: Urology 4 (January 2010): CMU.S4960. http://dx.doi.org/10.4137/cmu.s4960.

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Introduction This multicenter, randomized, double-blind, parallel-group, Phase III, pivotal trial investigated the efficacy and safety of solifenacin succinate 10 mg, a once-daily (OD) oral antimuscarinic agent, in overactive bladder syndrome (OAB). Materials and methods A total of 634 adult patients with OAB symptoms were randomized to either solifenacin 10 mg (n = 318) or placebo (n = 316) OD over 12 weeks, to examine changes from baseline in micturition-, incontinence-, urgency- and nocturia-episodes/24 hours, measured using a 3-day diary. Results Solifenacin significantly reduced the mean number of micturition-, urgency- and incontinence-episodes/24 hours at end of treatment ( P < 0.001 for all versus placebo); these improvements were observed at 4 weeks, and continued over 12 weeks. Adverse events were generally mild or moderate in severity and typically anticholinergic in nature. Conclusions Solifenacin 10 mg OD was well tolerated and effective in treating major OAB symptoms, including urinary incontinence, frequency and urgency.

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Ohkura, Naoki, Yoshihisa Hagihara, Tetsuro Yoshimura, Yuji Goto, and Hisao Kato. "Plasmin Can Reduce the Function of Human β2Glycoprotein I by Cleaving Domain V Into a Nicked Form." Blood 91, no. 11 (June 1, 1998): 4173–79. http://dx.doi.org/10.1182/blood.v91.11.4173.

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Abstract β2-Glycoprotein I (β2GPI) is a highly glycosylated plasma protein with the ability to bind negatively charged substances such as DNA, heparin, dextran sulfate, and negatively charged phospholipids. The most relevant physiological role of β2GPI is supposed to be the regulation of the function of anionic phospholipids like cardiolipin (CL). β2GPI consists of a single polypeptide chain (326 amino acid residues) with a molecular mass of about 50 kD and with five tandem repeated domains (I, II, III, IV, and V). In the previous study, we found that factor Xa can produce the nicked form by cleaving Lys 317-Thr 318, using recombinant human domain V (r-Domain V). However, the reaction was extremely slow. In the present paper, we found that plasmin can produce the nicked form of domain V, using recombinant domain V (r-Domain V) and β2GPI from human plasma. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, r-Domain V was rapidly cleaved into a nicked form by plasmin, very slowly by factor Xa, but not by thrombin, tissue-type plasminogen activator, urokinase, and tissue factor/factor VIIa. The cleavage site of r-Domain V and β2GPI by plasmin was proved to be Lys 317-Thr 318 by amino acid sequence analysis of the digest and of the C-terminal peptide isolated by high-performance liquid chromatography. The cleavage was completely inhibited by plasmin inhibitor (α2PI). The nicked form was demonstrated to show reduced affinity for CL with a dissociation constant of one order of magnitude larger than that of the intact β2GPI. To determine whether the specific cleavage of β2GPI by plasmin can occur also in plasma, human plasma was first acid-treated to inactivate α2PI and then incubated with urokinase. About 12% of β2GPI in plasma was nicked when α2PI activity decreased to 80%. The nicked form was not generated in plasminogen-depleted plasma. These results suggest that plasmin can produce the nicked form of β2GPI with the reduced ability to bind phospholipids in vivo.

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Ohkura, Naoki, Yoshihisa Hagihara, Tetsuro Yoshimura, Yuji Goto, and Hisao Kato. "Plasmin Can Reduce the Function of Human β2Glycoprotein I by Cleaving Domain V Into a Nicked Form." Blood 91, no. 11 (June 1, 1998): 4173–79. http://dx.doi.org/10.1182/blood.v91.11.4173.411k35_4173_4179.

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β2-Glycoprotein I (β2GPI) is a highly glycosylated plasma protein with the ability to bind negatively charged substances such as DNA, heparin, dextran sulfate, and negatively charged phospholipids. The most relevant physiological role of β2GPI is supposed to be the regulation of the function of anionic phospholipids like cardiolipin (CL). β2GPI consists of a single polypeptide chain (326 amino acid residues) with a molecular mass of about 50 kD and with five tandem repeated domains (I, II, III, IV, and V). In the previous study, we found that factor Xa can produce the nicked form by cleaving Lys 317-Thr 318, using recombinant human domain V (r-Domain V). However, the reaction was extremely slow. In the present paper, we found that plasmin can produce the nicked form of domain V, using recombinant domain V (r-Domain V) and β2GPI from human plasma. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, r-Domain V was rapidly cleaved into a nicked form by plasmin, very slowly by factor Xa, but not by thrombin, tissue-type plasminogen activator, urokinase, and tissue factor/factor VIIa. The cleavage site of r-Domain V and β2GPI by plasmin was proved to be Lys 317-Thr 318 by amino acid sequence analysis of the digest and of the C-terminal peptide isolated by high-performance liquid chromatography. The cleavage was completely inhibited by plasmin inhibitor (α2PI). The nicked form was demonstrated to show reduced affinity for CL with a dissociation constant of one order of magnitude larger than that of the intact β2GPI. To determine whether the specific cleavage of β2GPI by plasmin can occur also in plasma, human plasma was first acid-treated to inactivate α2PI and then incubated with urokinase. About 12% of β2GPI in plasma was nicked when α2PI activity decreased to 80%. The nicked form was not generated in plasminogen-depleted plasma. These results suggest that plasmin can produce the nicked form of β2GPI with the reduced ability to bind phospholipids in vivo.

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Satriyandari, Yekti, and Sri Handayani. "Hubungan secure attachment dengan dating violence pada mahasiswa prodi DIII kebidanan." Jurnal Kebidanan dan Keperawatan Aisyiyah 13, no. 1 (April 30, 2018): 69–80. http://dx.doi.org/10.31101/jkk.318.

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Abstract: The study aimed to investigate the correlation between secureattachment and dating violence. The study employed analytical surveywith cross sectional approach. Simple random sampling was used assample technique. Chi Square was used as the data analysis. The resultshowed that there were 31% dating violence and 69% without datingviolence. The result presented that there was the correlation with p-value0.001 < 0.05. The was the correlation between secure attachment anddating violence cases of D III Midwifery Program ‘Aisyiyah Universityof Yogyakarta. It is expected that the respondents can increase theirknowledge and awareness to protect themselves.

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Oberwinkler, Franz, Robert Bauer, and Robert J. Bandoni. "Colacogloea: a new genus in the auricularioid Heterobasidiomycetes." Canadian Journal of Botany 68, no. 12 (December 1, 1990): 2531–36. http://dx.doi.org/10.1139/b90-318.

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A new genus, Colacogloea, is described in the auricularioid Heterobasidiomycetes having simple septal pores. The genus is based on Platygloea peniophorae, a mycoparasite of some Aphyllophorales species. It is a segregate from the heterogeneous Platygloea s.l. The most important distinguishing features of Colacogloea are (i) the frequently simultaneous presence of basidial and conidial stages, (ii) a dimorphic life cycle including a yeast phase, (iii) mycoparasitism by colacosomes, (iv) simple septal pores with rounded margins, but without associated electron-opaque bandings and globules, and (v) aseptate basidiospores. Key words: Heterobasidiomycetes, Platygloea, Colacogloea peniophorae, mycoparasitism, colacosomes.

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YAEGASHI, Kimihiko, and Kazuyuki MIURA. "317 On Crank-Nicolson Method." Proceedings of Conference of Tohoku Branch 2001 (2001): 99–100. http://dx.doi.org/10.1299/jsmeth.2001.99.

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MAESHIMA, Takahiro, Satoshi YAMADA, Masahiro TODOH, and Shigeru TADANO. "318 Temperature-Duration Effects on Fracture Strength of Heat-Denatured Cortical Bone." Proceedings of Conference of Hokkaido Branch 2009.48 (2009): 103–4. http://dx.doi.org/10.1299/jsmehokkaido.2009.48.103.

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YOSHIDA, Kazuhiro, Yeon-Oh JUNG, and Shinichi YOKOTA. "318 A Microvalve Using MRF Drop : Proposition and Basic Experiments." Proceedings of Conference of Hokkaido Branch 2000.40 (2000): 130–31. http://dx.doi.org/10.1299/jsmehokkaido.2000.40.130.

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TOKUNAGA, Hitoo, and Shinpei TSUJINO. "318 Development of a heat engine using shape memory alloy coil spring." Proceedings of Conference of Chugoku-Shikoku Branch 2012.50 (2012): 31801–2. http://dx.doi.org/10.1299/jsmecs.2012.50.31801.

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Oyen, David, Jonathan L. Torres, Ulrike Wille-Reece, Christian F. Ockenhouse, Daniel Emerling, Jacob Glanville, Wayne Volkmuth, et al. "Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein." Proceedings of the National Academy of Sciences 114, no. 48 (November 14, 2017): E10438—E10445. http://dx.doi.org/10.1073/pnas.1715812114.

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Acquired resistance against antimalarial drugs has further increased the need for an effective malaria vaccine. The current leading candidate, RTS,S, is a recombinant circumsporozoite protein (CSP)-based vaccine against Plasmodium falciparum that contains 19 NANP repeats followed by a thrombospondin repeat domain. Although RTS,S has undergone extensive clinical testing and has progressed through phase III clinical trials, continued efforts are underway to enhance its efficacy and duration of protection. Here, we determined that two monoclonal antibodies (mAbs 311 and 317), isolated from a recent controlled human malaria infection trial exploring a delayed fractional dose, inhibit parasite development in vivo by at least 97%. Crystal structures of antibody fragments (Fabs) 311 and 317 with an (NPNA)3 peptide illustrate their different binding modes. Notwithstanding, one and three of the three NPNA repeats adopt similar well-defined type I β-turns with Fab311 and Fab317, respectively. Furthermore, to explore antibody binding in the context of P. falciparum CSP, we used negative-stain electron microscopy on a recombinant shortened CSP (rsCSP) construct saturated with Fabs. Both complexes display a compact rsCSP with multiple Fabs bound, with the rsCSP–Fab311 complex forming a highly organized helical structure. Together, these structural insights may aid in the design of a next-generation malaria vaccine.

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Reiss, Céleste A., Jan B. van Mechelen, Kees Goubitz, and René Peschar. "Reassessment of paracetamol orthorhombic Form III and determination of a novel low-temperature monoclinic Form III-m from powder diffraction data." Acta Crystallographica Section C Structural Chemistry 74, no. 3 (February 28, 2018): 392–99. http://dx.doi.org/10.1107/s2053229618002619.

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Paracetamol [N-(4-hydroxyphenyl)acetamide, C8H9NO2] has several polymorphs, just like many other drugs. The most stable polymorphs, denoted Forms I and II, can be obtained easily and their crystal structures are known. Crystals of the orthorhombic, less stable, room-temperature Form III are difficult to grow; they need a special recipe to crystallize and suffer from severe preferred orientation. A crystal structure model of Form III has been proposed and solved from a combination of structure prediction and powder X-ray diffraction (PXRD) [Perrinet al.(2009).Chem. Commun.22, 3181–3183]. The finalRwpvalue of 0.138 and the corresponding considerable residual trace were reasons to check its validity. A new structure determination of Form III using new high-resolution PXRD data led to a finalRwpvalue of 0.042 and an improvement of the earlier proposed model. In addition, a reversible phase transition was found at 170–220 K between the orthorhombic Form III and a novel monoclinic Form III-m. The crystal structure of Form III-m has been determined and refined from PXRD data to a finalRwpvalue of 0.059.

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Ojima, Hidefumi, Yuuki Shigematsu, Takashi Yamashita, and Masafumi Miwa. "313 Control of ducted fan flying object." Proceedings of Conference of Chugoku-Shikoku Branch 2011.49 (2011): 93–94. http://dx.doi.org/10.1299/jsmecs.2011.49.93.

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Xu, Qilong, Sunita V. Seemanapalli, Kristy McShan, and Fang Ting Liang. "Constitutive Expression of Outer Surface Protein C Diminishes the Ability of Borrelia burgdorferi To Evade Specific Humoral Immunity." Infection and Immunity 74, no. 9 (September 2006): 5177–84. http://dx.doi.org/10.1128/iai.00713-06.

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ABSTRACT The Lyme disease spirochete Borrelia burgdorferi reduces the expression of outer surface protein C (OspC) in response to the development of an anti-OspC humoral response, leading to the hypothesis that the ability to repress OspC expression is critical for the pathogen to proceed to chronic infection. B. burgdorferi was genetically modified to constitutively express OspC by introducing an extra ospC copy fused with the borrelial flagellar gene (flaB) promoter. Such a genetic modification did not reduce infectivity or pathogenicity in severe combined immunodeficiency mice but resulted in clearance of infection by passively transferred OspC antibody. Spirochetes with constitutive ospC expression were unable to establish chronic infections in immunocompetent mice unless they had undergone very destructive mutations in the introduced ospC copy. Two escape mutants were identified; one had all 7 bp deleted between the putative ribosome-binding site and the start codon, ATG, causing a failure in translational initiation, and the other mutant had an insertion of 2 bp between nucleotides 315 and 316, resulting in a nonsense mutation at codon 108. Thus, the ability of B. burgdorferi to repress ospC expression during mammalian infection allows the pathogen to avoid clearance and to preserve the integrity of the important gene for subsequent utilization during its enzootic life cycle.

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NAKAYAMA, Kenji, Sho KAMIYAMA, Satoshi TUNEMI, and Masafumi MIWA. "315 Study of Humanoid Skating Robot." Proceedings of Conference of Chugoku-Shikoku Branch 2011.49 (2011): 97–98. http://dx.doi.org/10.1299/jsmecs.2011.49.97.

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Paroli, Ralph M., Nancy T. Kawai, Ian S. Butler, and Denis F. R. Gilson. "Phase transitions in adamantane derivatives: 2-chloroadamantane." Canadian Journal of Chemistry 66, no. 8 (August 1, 1988): 1973–78. http://dx.doi.org/10.1139/v88-318.

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The phase transition behaviour of 2-chloroadamantane, 2-C10H15Cl, has been investigated by differential scanning calorimetry (DSC), and FT-IR and Raman spectroscopy. Two transitions were detected by both DSC and vibrational spectroscopy at 231 and 178 K, on cooling, and at 242 and 227 K, on heating. The measured enthalpies were 8.3 kJ mol−1 for the first transition (phase I → phase II), and 0.47 kJ mol−1 for the second (phase II → phase III). The entropies were 35 and 2.3 J K−1 mol−1, respectively. These are similar to those observed for other 2-substituted adamantanes, but significantly different from those for 1-substituted derivatives. The large hystereses observed for the two transitions are independent of the DSC scanning rate and are characteristic of first-order phase transitions. The dramatic differences observed in the vibrational spectra of phases I and II provide clear evidence of an order–disorder transition at about 235 K.

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NOMURA, Makoto, Takao KOIDE, Akio UEDA, and Atsutaka TAMURA. "318 Fatigue Life Prediction of Plastic Helical Wheels Meshed with Various Types of Worms." Proceedings of Conference of Chugoku-Shikoku Branch 2015.53 (2015): _318–1_—_318–2_. http://dx.doi.org/10.1299/jsmecs.2015.53._318-1_.

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Habib, A., L. D'Aoust, and D. Donnelly. "319 Micropropagation of Herbaceous Peony." HortScience 35, no. 3 (June 2000): 447B—447. http://dx.doi.org/10.21273/hortsci.35.3.447b.

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Micropropagation of herbaceous peony (Paeonia) cultivars and hybrids (Paula Fay, Cytherea, Prairie Moon, and Sarah Bernhardt) was investigated. Root clumps were removed from the field in February and forced in the greenhouse. Explants were excised buds from the crown area. Culture contamination levels were reduced by selection of crown buds prior to budbreak and disinfestation using combination treatments of 20 min with 5% potassium iodide followed by 10 min with 10% bleach. Genotypes responded differently to adventitious multiplication (Stage II) and tuberous root formation (Stage III) in Murashige and Skoog basal medium supplemented with 6-benzylaminopurine and gibberellic acid (Stage II) or indolebutyric acid (Stage III). Transfer to the greenhouse was accomplished (Stage IV) with a limited number of plants.

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Fisher, Perry W., Robert M. Currie, and Ralph J. Churchill. "SARA Title III, Section 313 —Looking Ahead." JAPCA 38, no. 11 (November 1988): 1376–79. http://dx.doi.org/10.1080/08940630.1988.10466476.

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Vidić, Adrijana. "Problemi prijevoda pripovijesti "Đavao" Marine Cvetajeve." Croatica et Slavica Iadertina, no. 1 (January 18, 2017): 401. http://dx.doi.org/10.15291/csi.313.

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U radu se pokušalo skrenuti pažnju na nekoliko problema, odnosno problemskih kategorija koje se pojavljuju pri prijevodu s ruskog jezika na hrvatski na primjeru autobiografskog teksta Marine Cvetajeve. Rad ne nastoji biti dijelom određenog teoretskog okvira ili donijeti neke smjernice na ovom polju nego prikazati prijevod kao proces s etapama – od detektiranja problema, preko domišljanja mogućnosti adekvatnog prijevoda do izbora optimalnog među njima. Problemi vezani uz taj tekst su podijeljeni u pet proizvoljnih problemskih kategorija. Prva od njih bavi se autoričinim neologizmima i mogućnostima prevoditeljskih iznalaženja. Druga ima za cilj ukazati na različite varijante prijevoda jedne riječi koja nema jednak gramatički rod u dvama jezicima, ovisno o njenoj funkciji. Treća dodaje nekoliko primjera vezanih uz uvijek aktualnu temu nemogućnosti kulturne prevodivosti te pokazuje put dokompromisnih rješenja. Dvije konačne se bave rimom u prozi i ortografskim problemima.

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Mills, W. J. "Fracture toughness of type 304 and 316 stainless steels and their welds." International Materials Reviews 42, no. 2 (January 1997): 45–82. http://dx.doi.org/10.1179/imr.1997.42.2.45.

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LI, SHA, YANG GAO, XIU-JUAN JIA, HAO SUN, RONG-SHUN WANG, and XIU-MEI PAN. "THEORETICAL MECHANISTIC STUDY ON THE RADICAL-NEUTRAL REACTION OF CH(X2Π) WITH CH2CO." Journal of Theoretical and Computational Chemistry 09, no. 02 (April 2010): 423–33. http://dx.doi.org/10.1142/s0219633610005724.

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A theoretical survey on the potential energy surface for the CH (X2Π) + CH2CO reaction has been carried out. The geometries and energies of all stationary points involved in the reaction are calculated at the UB3LYP/6-311+G(d, p) level. And the more accurate energy information is provided by single point calculations at the UCCSD(T)/6-311++G(2d, 2p) level. Relationships of the reactants, transition states, intermediates, and products are confirmed by the intrinsic reaction coordinate (IRC) calculations. Our calculations demonstrate that this reaction is most likely initiated by carbon-to-olefinic carbon attack manners. The results suggest that P1 (C2H3 + CO) is the most important product through two competitive channels R → IM1 → TS1/P1 → P1 (C2H3 + CO) and R → IM1 → TS1/6 → IM6 → TS6/P1 → P1 (C2H3 + CO) . This study presents highlights of the mechanism of the title reaction, which is in good agreement with experimental results.

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Durazo Terán, Luis Alberto, Manuel Francisco De la Cruz Ortega, Andrés Aquilino Castro Zamora, and Ricardo López García. "Actividad física, prevalencia de sobrepeso y obesidad en estudiantes universitarios de Entrenamiento Deportivo." Revista Iberoamericana de Ciencias de la Actividad Física y el Deporte 10, no. 2 (July 21, 2021): 48–59. http://dx.doi.org/10.24310/riccafd.2021.v10i2.12152.

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El objetivo fue analizar el nivel de actividad física, la prevalencia de sobrepeso y obesidad a través del Índice de Masa Corporal (IMC) y Porcentaje de Grasa Corporal (%GC), como indicadores de riesgo sobre la salud en estudiantes universitarios. El estudio se caracterizó por ser transversal, con enfoque mixto, no experimental y descriptivo. La muestra fue conformada por 66 hombres y 65 mujeres, todos estudiantes de la carrera de entrenamiento deportivo. Entre los principales resultados se observó un IMC de 24.6 ± 3.7 en hombres mientras que en mujeres 23.8 ± 3.8, sin diferencias significativas. El %GC fue de 14.4 ± 5.7 en hombres y de 27.6 ± 6.3 en mujeres, con diferencias significativas (p=0.000) y una prevalencia de sobrepeso del 31.8% en hombres y 24.6% en mujeres. Se concluye que la Identificación en tiempo de sobrepeso y obesidad en estudiantes universitarios, podría ser preventivo en riesgos de la salud.

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Macartney, Donal H. "The oxidation of hydrogen peroxide by tris(polypyridine) complexes of osmium(III), iron(III), ruthenium(III), and nickel(III) in aqueous media." Canadian Journal of Chemistry 64, no. 9 (September 1, 1986): 1936–42. http://dx.doi.org/10.1139/v86-319.

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The stoichiometry and kinetics of the oxidation of hydrogen peroxide by tris(2,2′-bipyridine) and tris(4,4′-dimethyl-2,2′-bipyridine) complexes of osmium(III), iron(III), ruthenium(III), and nickel (III) were studied in acidic and neutral aqueous media at 25 °C and I = 0.50 M (LiCF3SO3). The reaction 2M(bpy)33+ + H2O2 → 2M(bpy)32+ + O2 + 2H+ is observed with quantitative yields of dioxygen gas. The observed rate constants displayed an inverse acid dependence over the pH range 6.0–8.5; kobsd = k1 + k2K1/[H+], attributed to the oxidations of H2O2(k1) and HO2− (k2). An application of the Marcus theory relationship to the cross-reaction data gave a self-exchange rate constant of 10−2–10−1 M−1 s−1 for the HO2−/HO2 couple. The electron exchange rate constant is evaluated in terms of the inner-sphere and solvent reorganizational barriers and is compared to values reported for other small molecule couples. Rate and activation parameters for the reduction of the nickel(III) complexes by the hydroxide ion have been determined and are compared with the corresponding values for other metal tris(poly pyridine) complexes.

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Mihos, Christos G., Andrés M. Pineda, Hector Davila, Maiteder C. Larrauri-Reyes, and Orlando Santana. "Combined Mitral and Tricuspid Valve Surgery Performed via a Right Minithoracotomy Approach." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 10, no. 5 (September 2015): 304–8. http://dx.doi.org/10.1097/imi.0000000000000191.

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Objective Combined mitral and tricuspid valve surgery is associated with an increased perioperative morbidity and mortality. We evaluated the outcomes of a less invasive right minithoracotomy approach in patients undergoing primary or reoperative double-valve surgery. Methods We retrospectively evaluated 132 consecutive patients with mitral and tricuspid valve disease who underwent double-valve surgery via a right minithoracotomy at our institution between January 2009 and April 2014. Results The cohort included 81 female (61%) and 51 male (39%) patients, with a mean ± SD age of 67 ± 13 years. The mean ± SD preoperative left ventricular ejection fraction, mitral regurgitation grade, and creatinine were 53% ± 12%, 3.8 ± 0.6, and 1.26 ± 1.17, respectively. The patients underwent primary (88%) or reoperative (12%) mitral and tricuspid valve surgery, which consisted of 88 mitral repairs (67%), 44 mitral replacements (33%), 131 tricuspid repairs (99%), and 1 tricuspid replacement (1%). Postoperatively, there were 6 cases of acute kidney injury (5%), 6 reoperations for bleeding (5%), 4 cerebrovascular accidents (3%), and 12 cases of atrial fibrillation (9%). The median intensive care unit length of stay and total hospital lengths of stay were 61 hours (interquartile range, 43–112 hours) and 8 days (interquartile range, 6–13 days), respectively. The in-hospital mortality was 4%. Actuarial survival at 1 and 5 years was 93% and 88%, respectively. Conclusions In patients undergoing primary or reoperative mitral and tricuspid valve surgery, a right minithoracotomy approach is associated with a low perioperative morbidity and good midterm survival.

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Harrold, Emily, Megan Greally, Niamh Peters, Jane Sze Yin Sui, and John McCaffrey. "Adjuvant chemotherapy (AC) for stage III colorectal cancer (CRC) in the elderly: An Irish experience." Journal of Clinical Oncology 38, no. 4_suppl (February 1, 2020): 54. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.54.

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54 Background: Since 2004 6 months of adjuvant Oxaliplatin containing regimens (OCR) has been standard of care for Stage III CRC despite cumulative neurotoxicity. The IDEA collaboration evaluated 3 versus 6 months of OCR in high/low risk pts with regard to peripheral neuropathy (PN) and efficacy.The median pt age was 64; individual studies included pts ≤85. Methods: This study is part of a retrospective review of the clinicopathological records of consecutive CRC pts referred to the multi-disciplinary CRC team at an Irish tertiary referral centre from 2002-2018. We recorded pt characteristics, Rx received and outcomes. Overall Survival (OS) was assessed using Kaplan-Meier analysis. Results: 869 pts were identified; 37% (328) female. 63% (551/869) < 70 and 37% (318/869) ≥ 70. Median OS for < 70 cohort was 31.5 months versus 19 months in ≥ 70 cohort (p < 0.0001).Stage distribution in < 70: ≥70 cohorts was Stage II 14%( 79/551):20% (63/318), Stage III 47% (260/55):46% (142/318) and Stage IV 38% (207/551):34% (111/318). In < 70 Stage III cohort 7% (37/551) pts received no AC, 42%(230/551) received FOLFOX, 3%(16/551) received FLOX or XELOX, 7%(38/551) received 5FU/LEU. 32%(78/246) of pts < 70 developed PN with persistence at 6 months in 18%(44/256). In ≥ 70 Stage III cohort 58%(83/142) did not received AC. 23%(32/142) received an OCR and 16%(23/142) received 5FU/LEU; there was a statistically significant survival difference with an OCR. 47% (15/32) of pts ≥70 receiving OCR developed PN which persisted at 6 months in 28% (9/32). In < 70 cohort there was no significant survival difference in the IDEA-trial-defined low risk group between 12 versus < 12 FOLFOX. There was a numerical survival difference in the < 70 high risk group between 12 versus < 12 FOLFOX; this was not statistically significant. In the ≥70 age group there was no survival difference in either IDEA risk groups for 12 versus < 12 FOLFOX. Conclusions: > 50% of Stage III CRC patients ≥ 70 did not receive AC. OCRs were associated with a significant OS improvement but with higher PN than in < 70 cohort and higher persistence at 6 months. Irrespective of IDEA-defined risk groups,there was no statistically significant survival difference for Stage III CRC ≥70 receiving 12 versus < 12 FOLFOX.

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Singh, Yogendra, Kurt R. Klimpel, Seema Goel, Prabodha K. Swain, and Stephen H. Leppla. "Oligomerization of Anthrax Toxin Protective Antigen and Binding of Lethal Factor during Endocytic Uptake into Mammalian Cells." Infection and Immunity 67, no. 4 (April 1, 1999): 1853–59. http://dx.doi.org/10.1128/iai.67.4.1853-1859.1999.

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ABSTRACT The protective antigen (PA) protein of anthrax toxin binds to a cellular receptor and is cleaved by cell surface furin to produce a 63-kDa fragment (PA63). The receptor-bound PA63 oligomerizes to a heptamer and acts to translocate the catalytic moieties of the toxin, lethal factor (LF) and edema factor (EF), from endosomes to the cytosol. In this report, we used nondenaturing gel electrophoresis to show that each PA63 subunit in the heptamer can bind one LF molecule. Studies using PA immobilized on a plastic surface showed that monomeric PA63 is also able to bind LF. The internalization of PA and LF by cells was studied with radiolabeled and biotinylated proteins. Uptake was relatively slow, with a half-time of 30 min. The number of moles of LF internalized was nearly equal to the number of moles of PA subunit internalized. The essential role of PA oligomerization in LF translocation was shown with PA protein cleaved at residues 313-314. The oligomers formed by these proteins during uptake into cells were not as stable when subjected to heat and detergent as were those formed by native PA. The results show that the structure of the toxin proteins and the kinetics of proteolytic activation, LF binding, and internalization are balanced in a way that allows each PA63 subunit to internalize an LF molecule. This set of proteins has evolved to achieve highly efficient internalization and membrane translocation of the catalytic components, LF and EF.

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Engstrom, Michael D., Christopher J. Alteri, and Harry L. T. Mobley. "A Conserved PapB Family Member, TosR, Regulates Expression of the Uropathogenic Escherichia coli RTX Nonfimbrial Adhesin TosA while Conserved LuxR Family Members TosE and TosF Suppress Motility." Infection and Immunity 82, no. 9 (June 16, 2014): 3644–56. http://dx.doi.org/10.1128/iai.01608-14.

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ABSTRACTA heterogeneous subset of extraintestinal pathogenicEscherichia coli(ExPEC) strains, referred to as uropathogenicE. coli(UPEC), causes most uncomplicated urinary tract infections. However, no core set of virulence factors exists among UPEC strains. Instead, the focus of the analysis of urovirulence has shifted to studying broad classes of virulence factors and the interactions between them. For example, the RTX nonfimbrial adhesin TosA mediates adherence to host cells derived from the upper urinary tract. The associatedtosoperon is well expressedin vivobut poorly expressedin vitroand encodes TosCBD, a predicted type 1 secretion system. TosR and TosEF are PapB and LuxR family transcription factors, respectively; however, no role has been assigned to these potential regulators. Thus, the focus of this study was to determine how TosR and TosEF regulatetosAand affect the reciprocal expression of adhesins and flagella. Among a collection of sequenced UPEC strains, 32% (101/317) were found to encode TosA, and nearly all strains (91% [92/101]) simultaneously carried the putative regulatory genes. Deletion oftosRalleviatestosArepression. Thetospromoter was localized upstream oftosRusing transcriptional fusions of putative promoter regions withlacZ. TosR binds to this region, affecting a gel shift. A 100-bp fragment 220 to 319 bp upstream oftosRinhibits binding, suggesting localization of the TosR binding site. TosEF, on the other hand, downmodulate motility when overexpressed by preventing the expression offliC, encoding flagellin. Deletion oftosEFincreased motility. Thus, we present an additional example of the reciprocal control of adherence and motility.

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Currie, Maria E., A. Jonathan McLeod, John T. Moore, Michael W. A. Chu, Rajni Patel, Bob Kiaii, and Terry M. Peters. "Augmented Reality System for Ultrasound Guidance of Transcatheter Aortic Valve Implantation." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 11, no. 1 (January 2016): 31–39. http://dx.doi.org/10.1097/imi.0000000000000235.

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Objective Transcatheter aortic valve implantation (TAVI) relies on fluoroscopy and nephrotoxic contrast medium for valve deployment. We propose an alternative guidance system using augmented reality (AR) and transesophageal echocardiography (TEE) to guide TAVI deployment. The goals of this study were to determine how consistently the aortic valve annulus is defined from TEE using different aortic valve landmarks and to compare AR guidance with fluoroscopic guidance of TAVI deployment in an aortic root model. Methods Magnetic tracking sensors were integrated into the TAVI catheter and TEE probe, allowing these tools to be displayed in an AR environment. Variability in identifying aortic valve commissures and cuspal nadirs was assessed using TEE aortic root images. To compare AR guidance of TAVI deployment with fluoroscopic guidance, a TAVI stent was deployed 10 times in the aortic root model using each of the two guidance systems. Results Commissures and nadirs were both investigated as features for defining the valve annulus in the AR guidance system. The commissures were identified more consistently than the nadirs, with intraobserver variability of 2.2 and 3.8 mm, respectively, and interobserver variability of 3.3 and 4.7 mm, respectively. The precision of TAVI deployment using fluoroscopic guidance was 3.4 mm, whereas the precision of AR guidance was 2.9 mm, and its overall accuracy was 3.4 mm. This indicates that both have similar performance. Conclusions Aortic valve commissures can be identified more reliably than cuspal nadirs from TEE. The AR guidance system achieved similar deployment accuracy to that of fluoroscopy while eliminating the use and consequences of nephrotoxic contrast and radiation.

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Rodriguez, Maria L., Harry R. Lapierre, Benjamin Sohmer, Jean-Philippe Ruel, and Marc A. Ruel. "Predictors and Outcomes of Sternotomy Conversion and Cardiopulmonary Bypass Assistance in Minimally Invasive Coronary Artery Bypass Grafting." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 11, no. 5 (September 2016): 315–20. http://dx.doi.org/10.1097/imi.0000000000000309.

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Objective This work's objective was to identify the determinants of conversion of minimally invasive coronary artery bypass grafting to sternotomy, with and without cardiopulmonary bypass assistance, and to compare clinical outcomes in patients who needed conversion. Methods This is a prospectively collected data on patients who underwent minimally invasive coronary bypass done by a single surgeon from February 2005 to September 2014. Statistical analyses were expressed as mean values ± standard deviation or proportions. Results The total number of patients was 266, with an average age of 62 years. The median number of grafted territories was 2, higher in those with pump assistance (median, 3 grafts; P ≤ 0.01). Predictors for use of cardiopulmonary bypass included diabetes, 3-vessel disease, left circumflex involvement, and small target vessels (P < 0.05). The rate for sternotomy conversion was 3.8%. Risk factors for conversion to sternotomy included smoking, preoperative bradycardia (<50 beats per minute), low intraoperative ejection fraction, inability to tolerate one-lung ventilation, inadequate surgical exposure, and hemodynamic instability. Postoperative complications included superficial thoracotomy infection (3%), sternotomy infection (10%), new atrial fibrillation (3%), and need for blood transfusion (14%). Twelve patients (5%) developed left-sided pleural effusion that required drainage. There were no perioperative deaths, major adverse cardiac event, or stroke. Conclusions Minimally invasive coronary bypass grafting with conversion to sternotomy and use of cardiopulmonary bypass is safe. Conversions may be alleviated by an effort to optimize modifiable risk factors and the adequacy of surgical exposure. These data may help develop objective selection criteria to identify patients who are excellent candidates for the procedure.

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Stoliński, Jarosław, Robert Musiał, Dariusz Plicner, and Janusz Andres. "Respiratory System Function in Patients after Minimally Invasive Aortic Valve Replacement Surgery." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 12, no. 2 (March 2017): 127–36. http://dx.doi.org/10.1097/imi.0000000000000349.

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Objective The aim of the study was to comparatively analyze respiratory system function after minimally invasive, through right minithoracotomy aortic valve replacement (RT-AVR) to conventional AVR. Methods Analysis of 201 patients scheduled for RT-AVR and 316 for AVR between January 2010 and November 2013. Complications of the respiratory system and pulmonary functional status are presented. Results Complications of the respiratory system occurred in 16.8% of AVR and 11.0% of RT-AVR patients ( P = 0.067). The rate of pleural effusions, thoracenteses, pneumonias, or phrenic nerve dysfunctions was not significantly different between groups. Perioperative mortality was 1.9% in AVR and 1.0% in RT-AVR ( P = 0.417). Mechanical ventilation time after surgery was 9.7 ± 5.9 hours for AVR and 7.2 ±3.2 hours for RT-AVR patients ( P < 0.001). Stroke (odds ratio [OR] = 13.4, P = 0.008), increased postoperative blood loss (OR = 9.6, P <0.001), and chronic obstructive pulmonary disease (OR = 7.7, P < 0.001) were risk factors of prolonged mechanical lung ventilation. A week after surgery, the results of most pulmonary function tests were lower in the AVR than in the RT-AVR group ( P < 0.001 was seen for forced expiratory volume in the first second, vital capacity, total lung capacity, maximum inspiratory pressure and maximum expiratory pressure, P = 0.377 was seen for residual volume). Conclusions Right anterior aortic valve replacement minithoracotomy surgery with single-lung ventilation did not result in increased rate of respiratory system complications. Spirometry examinations revealed that pulmonary functional status was more impaired after AVR in comparison with RT-AVR surgery.

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Goodman, Avi, Marijan Koprivanac, Marta Kelava, Stephanie L. Mick, A. Marc Gillinov, Jeevanantham Rajeswaran, Anna Brzezinski, Eugene H. Blackstone, and Tomislav Mihaljevic. "Robotic Mitral Valve Repair." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 12, no. 6 (November 2017): 390–97. http://dx.doi.org/10.1097/imi.0000000000000438.

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Objective Adoption of robotic mitral valve surgery has been slow, likely in part because of its perceived technical complexity and a poorly understood learning curve. We sought to correlate changes in technical performance and outcome with surgeon experience in the “learning curve” part of our series. Methods From 2006 to 2011, two surgeons undertook robotically assisted mitral valve repair in 458 patients (intent-to-treat); 404 procedures were completed entirely robotically (as-treated). Learning curves were constructed by modeling surgical sequence number semiparametrically with flexible penalized spline smoothing best-fit curves. Results Operative efficiency, reflecting technical performance, improved for (1) operating room time for case 1 to cases 200 (early experience) and 400 (later experience), from 414 to 364 to 321 minutes (12% and 22% decrease, respectively), (2) cardiopulmonary bypass time, from 148 to 102 to 91 minutes (31% and 39% decrease), and (3) myocardial ischemic time, from 119 to 75 to 68 minutes (37% and 43% decrease). Composite postoperative complications, reflecting safety, decreased from 17% to 6% to 2% (63% and 85% decrease). Intensive care unit stay decreased from 32 to 28 to 24 hours (13% and 25% decrease). Postoperative stay fell from 5.2 to 4.5 to 3.8 days (13% and 27% decrease). There were no in-hospital deaths. Predischarge mitral regurgitation of less than 2+, reflecting effectiveness, was achieved in 395 (97.8%), without correlation to experience; return-to-work times did not change substantially with experience. Conclusions Technical efficiency of robotic mitral valve repair improves with experience and permits its safe and effective conduct.

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Ginty, Olivia K., John M. Moore, Yuanwei Xu, Wenyao Xia, Satoru Fujii, Daniel Bainbridge, Terry M. Peters, Bob B. Kiaii, and Michael W. A. Chu. "Dynamic Patient-Specific Three-Dimensional Simulation of Mitral Repair." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 1 (January 2018): 11–22. http://dx.doi.org/10.1097/imi.0000000000000463.

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Objective Planned mitral repair strategies are generally established from preoperative echocardiography; however, specific details of the repair are often determined intraoperatively. We propose that three-dimensional printed, patient-specific, dynamic mitral valve models may help surgeons plan and trial all the details of a specific patient's mitral repair preoperatively. Methods Using preoperative echocardiography, segmentation, modeling software, and three-dimensional printing, we created dynamic, high-fidelity, patient-specific mitral valve models including the subvalvular apparatus. We assessed the accuracy of 10 patient mitral valve models anatomically and functionally in a heart phantom simulator, both objectively by blinded echocardiographic assessment, and subjectively by two mitral repair experts. After this, we attempted model mitral repair and compared the outcomes with postoperative echocardiography. Results Model measurements were accurate when compared with patients on anterior-posterior diameter, circumference, and anterior leaflet length; however, less accurate on posterior leaflet length. On subjective assessment, Likert scores were high at 3.8 ± 0.4 and 3.4 ± 0.7, suggesting good fidelity of the dynamic model echocardiogram and functional model in the phantom to the preoperative three-dimensional echocardiogram, respectively. Mitral repair was successful in all 10 models with significant reduction in mitral insufficiency. In two models, mitral repair was performed twice, using two different surgical techniques to assess which provided a better outcome. When compared with the actual patient mitral repair outcome, the repaired models compared favorably. Conclusions Complex mitral valve modeling seems to predict an individual patient's mitral anatomy well, before surgery. Further investigation is required to determine whether deliberate preoperative practice can improve mitral repair outcomes.

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Etienne, Pierre Yves, David Glineur, Spiridon Papadatos, Gregory Kalscheuer, Yves Mairy, Munir Boodhwani, Gebrine El Khoury, Philippe Noirhomme, and Claude Hanet. "Comparison of Minimally Invasive Direct Coronary Artery Bypass Surgery with Implantation of Drug-Eluting Stents in Patients with Left Anterior Descending Coronary Artery Disease." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 4, no. 6 (October 2009): 340–44. http://dx.doi.org/10.1097/imi.0b013e3181c49e8b.

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Objective Bypass surgery and percutaneous coronary interventions improve the clinical status of patients with left anterior descending coronary artery disease. However, these techniques differ in invasiveness and in the need for subsequent reinterventions. The development of minimally invasive direct coronary artery bypass (MIDCAB) surgery and of drug-eluting stents (DES) offers perspectives to close this gap. Methods We compared the long-term clinical outcome of 308 patients after revascularization for isolated left anterior descending coronary artery disease. One hundred fifty-four patients were treated with MIDCAB and 154 with percutaneous coronary interventions and DES implantation. Results Both groups were similar in age (63 ± 13 and 62 ± 10 years), Euroscore (3.3 ± 2.8 and 3.4 ± 2.6), and mean duration of follow-up (30 ± 17 and 24 ± 10 months). Two-year survival was similar after MIDCAB and after DES (97.4% and 94.8%). During follow-up, four patients (2.6%) of the MIDCAB group and 21 patients (13.6%) of the DES group needed subsequent revascularization of the target vessel (P = 0.001). Revascularization of a nontarget vessel was needed in 11 patients (7%) of the MIDCAB group and in 17 patients (11%) of the DES group (NS). Neurologic complications included two transient ischemic accidents and two strokes in the MIDCAB group but three fatal cerebral hemorrhages and one stroke in the DES group. Major adverse coronary and cerebrovascular events rates were 14% in the MIDCAB and 31% in the DES group. Conclusions MIDCAB and DES implantation showed similar rates of mortality but a higher reintervention rate after DES. Anticoagulation implications remain critical for the future of DES.

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Van Phung, Doan, Takeshi Kinoshita, Tohru Asai, and Tomoaki Suzuki. "Histological and Morphometric Properties of Skeletonized Gastroepiploic Artery and Risk Factors for Intimal Hyperplasia." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 7, no. 3 (May 2012): 191–94. http://dx.doi.org/10.1097/imi.0b013e318264f4cb.

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Objective The aim of the present study was to examine the histological and morphometric properties of skeletonized gastroepiploic artery (GEA) and the risk factors for intimal hyperplasia. Methods We obtained the redundant distal segments of skeletonized GEAs from 33 patients undergoing coronary bypass surgery and microscopically examined the transverse sections just distal to the most distal anastomoses. Intimal hyperplasia was evaluated on the basis of intima-to-media ratio and percentage of luminal narrowing. Risk factors were examined using multivariate linear regression analysis. Results The median (range) of lumen diameter at the most distal anastomosis was 3.8 (2.4–6.4) mm; width of intima, 82 (8–418) μm; width of media, 167 (88–351) μm; wall thickness, 250 (118–554) μm; intima-to-media ratio, 0.59 (0.04–3.88), and percentage of luminal narrowing, 12.3 (1.5–28.9). The number of elastic lamina in the media was 4.2 ± 1.8. Atherosclerosis was found in six patients, and medial calcification, in three patients. The median (range) of graft flow and pulsatile index measured by intraoperative transit-time flow meter was 65 (11–141) mL/min and 3.1 (1.4–5.9), respectively. All GEA grafts were patent at the coronary computed tomography angiography before discharge. Estimated glomerular filtration rate was independently associated with intima-to-media ratio (β coefficient = −0.016, P < 0.01) and percentage of luminal narrowing (β coefficient = −0.012, P < 0.01). Conclusions Skeletonized GEA had sufficient lumen diameter with excellent graft flow and early patency even when used as a sequential graft. Estimated glomerular filtration rate correlates significantly with intimal hyperplasia.

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Sarkaria, Inderpal S., Nabil P. Rizk, Rachel Grosser, Debra Goldman, David J. Finley, Amanda Ghanie, Camelia S. Sima, et al. "Attaining Proficiency in Robotic-Assisted Minimally Invasive Esophagectomy While Maximizing Safety during Procedure Development." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 11, no. 4 (July 2016): 268–73. http://dx.doi.org/10.1097/imi.0000000000000297.

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Objective Robotic-assisted minimally invasive esophagectomy (RAMIE) is an emerging complex operation with limited reports detailing morbidity, mortality, and requirements for attaining proficiency. Our objective was to develop a standardized RAMIE technique, evaluate procedure safety, and assess outcomes using a dedicated operative team and 2-surgeon approach. Methods We conducted a study of sequential patients undergoing RAMIE from January 25, 2011, to May 5, 2014. Intermedian demographics and perioperative data were compared between sequential halves of the experience using the Wilcoxon rank sum test and the Fischer exact test. Median operative time was tracked over successive 15-patient cohorts. Results One hundred of 313 esophageal resections performed at our institution underwent RAMIE during the study period. A dedicated team including 2 attending surgeons and uniform anesthesia and OR staff was established. There were no significant differences in age, sex, histology, stage, induction therapy, or risk class between the 2 halves of the study. Estimated blood loss, conversions, operative times, and overall complications significantly decreased. The median resected lymph nodes increased but was not statistically significant. Median operative time decreased to approximately 370 minutes between the 30th and the 45th cases. There were no emergent intraoperative complications, and the anastomotic leak rate was 6% (6/100). The 30-day mortality was 0% (0/100), and the 90-day mortality was 1% (1/100). Conclusions Excellent perioperative and short-term patient outcomes with minimal mortality can be achieved using a standardized RAMIE procedure and a dedicated team approach. The structured process described may serve as a model to maximize patients’ safety during development and assessment of complex novel procedures.

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D'Onofrio, Augusto, Lorenzo Bagozzi, Chiara Tessari, Annalisa Francescato, Giorgia Cibin, Laura Besola, Rita Pesce, Giuseppe Toscano, and Gino Gerosa. "Evaluation of Conduction Disorders after Aortic Valve Replacement with Rapid Deployment Bioprostheses." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 5 (September 2018): 356–60. http://dx.doi.org/10.1097/imi.0000000000000558.

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Objective The aim of this retrospective, single-center study was to evaluate the occurrence of conduction disorders after rapid deployment aortic bioprosthesis implantation. Methods Electrocardiograms of patients undergoing INTUITY (Edwards Lifesciences, Irvine, CA USA) bioprosthesis implantation were collected at admission, during postoperative course, and at discharge. Primary end point was the occurrence of new-onset conduction disorders, defined as complete left bundle branch block, complete right bundle branch block, permanent pacemaker implantation, and worsening of pre-existing rhythm abnormalities. Secondary end points were the assessment of preoperative and postoperative QRS duration and the identification of transitory conduction disorders. Results Forty-four patients (July 2015–December 2016) were included in the analysis. Preoperatively, patients with normal conduction and with already existing disorders were 25 (56.8%) and 19 (43.2%), respectively. Primary end point occurred in 14 patients (31.8%). Two patients (4.5%) received pacemaker implantation. In patients with normal preoperative conduction, new abnormalities were found in eight cases (32%): all left bundle branch blocks with one pacemaker implantation. Worsening of pre-existing conduction disorders was found in six patients (31.6%) with one pacemaker implantation. QRS duration increased in 20 patients (45.4%), and average increase was 37 milliseconds. Overall, we observed a significant increase of QRS (96 ± 21 milliseconds vs. 111 ± 28 milliseconds, P < 0.001). Three patients experienced a new-onset temporary left bundle branch block. Conclusions New-onset conduction disorders or worsening of pre-existing rhythm abnormalities occur in one third of patients after rapid deployment aortic bioprosthesis implantation. Although the incidence of postoperative pacemaker implantation before discharge is low, strict follow-up is mandatory to identify a potential need for pacemaker implantation in a timely manner.

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Hemli, Jonathan M., Lucas W. Henn, Christopher R. Panetta, Jenny S. Suh, Scott R. Shukri, Joan M. Jennings, Gregory P. Fontana, and Nirav C. Patel. "Defining the Learning Curve for Robotic-Assisted Endoscopic Harvesting of the Left Internal Mammary Artery." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 8, no. 5 (June 2013): 353–58. http://dx.doi.org/10.1097/imi.0000000000000017.

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Objective Robotic-assisted techniques are continuing to cement their role in coronary surgery, particularly in facilitating the endoscopic harvesting of the left internal mammary artery (LIMA), regardless of how the subsequent bypass grafting is performed. As more surgeons attempt to become trained in robotic-assisted procedures, we sought to better define the learning curve associated with robotic-assisted endoscopic LIMA harvest. Methods Between January 2011 and July 2012, a total of 77 patients underwent robotic-assisted minimally invasive direct coronary artery bypass surgery at our institution. The LIMA was harvested endoscopically in all patients, using standard robotic instruments, followed by direct grafting to anterior wall myocardial vessels via a small thoracotomy. Intraoperative times for various components of the procedure were collated and analyzed. Results The mean ± SD time taken to insert and position the ports for the robotic instruments was 3.9 ± 1.4 minutes. The mean ± SD LIMA harvest time was 31.8 ± 10.1 minutes, and the mean ± SD total robotic time was 44.2 ± 12.9 minutes. All time variables consistently continued to decrease as the experience of the operating surgeon increased, with the greatest magnitude of improvement being evident within the first 20 cases. The logarithmic learning curves for LIMA harvest time and total robot time during our entire experience were both calculated as 90%, correlating to an expected 10% improvement in performance for each doubling of cases completed. Conclusions Coronary surgeons can rapidly become proficient in robotic-assisted endoscopic LIMA harvest, with significant improvement in operative times evident within the first 20 cases completed. These data may be useful in designing appropriate training programs for newer surgeons seeking to gain experience in robotic-assisted coronary surgery.

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Journal articles on the topic 'IMI 318'

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